EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20501939Stress-induced phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation.Mol Cell Proteomics2010 SepWang THdoi: 10.1074/mcp.M110.000802
29596884STIP1 is over-expressed in hepatocellular carcinoma and promotes the growth and migration of cancer cells.Gene2018 Jul 1Luo Xdoi: 10.1016/j.gene.2018.03.076
30076803Prognostic significance of STIP1 expression in human cancer: A meta-analysis.Clin Chim Acta2018 NovZhang Sdoi: 10.1016/j.cca.2018.07.037
22824801C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.Oncogene2013 Jun 20Muller Pdoi: 10.1038/onc.2012.314
23915849Immunohistological analysis of stress-induced phosphoprotein 1 in ovarian cancer patients with low serum cancer antigen 125 levels.Taiwan J Obstet Gynecol2013 JunChao Adoi: 10.1016/j.tjog.2013.04.006.
21470770RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.Cancer Lett2011 Jul 28Walsh Ndoi: 10.1016/j.canlet.2011.03.004
24488757Expression of stress-induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer.Genes Chromosomes Cancer2014 AprCho Hdoi: 10.1002/gcc.22136
29559743Stress-induced phosphoprotein 1 mediates hepatocellular carcinoma metastasis after insufficient radiofrequency ablation.Oncogene2018 JunSu Tdoi: 10.1038/s41388-018-0169-4

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1164203599SilentNAQ512Q0.18
BLCAchr1164203582Missense_MutationnovelI507V0.07
BLCAchr1164194293SilentnovelL108L0.08
BLCAchr1164200209Missense_MutationnovelI387M0.15
BLCAchr1164194582SilentnovelL155L0.32
BLCAchr1164202882Missense_MutationNAE418K0.25
BLCAchr1164203594Missense_MutationnovelM511V0.17
BLCAchr1164203614SilentnovelA517A0.21
BLCAchr11642042023'UTRnovel0.36
BRCAchr1164197943Missense_MutationNAR331Q0.17
BRCAchr1164194493Missense_MutationnovelN126D0.09
BRCAchr1164193267Missense_MutationNAL67V0.15
BRCAchr11641862265'UTRnovel0.23
BRCAchr11642042363'UTRnovel0.29
BRCAchr1164203208Missense_MutationNAD456H0.17
CESCchr1164195662Missense_Mutationrs769710155R174Q0.11
CESCchr1164197493Missense_MutationnovelA267V0.39
CESCchr1164194501Missense_MutationNAF128L0.18
COADchr1164195820Splice_Regionnovel0.36
COADchr1164197539Nonsense_MutationNAC282*0.1
COADchr1164200020SilentNAN368N0.25
COADchr1164195726Missense_MutationnovelE195D0.43
COADchr1164195681Silentrs373218763S180S0.24
COADchr1164199999In_Frame_DelNAE363del0.43
COADchr1164203454Missense_MutationNAA464V0.46
COADchr1164203525Nonsense_MutationNAR488*0.46
COADchr1164203525Nonsense_MutationNAR488*0.35
COADchr1164197326Missense_Mutationrs747004405T243I0.07
COADchr1164194195Missense_MutationNAS76P0.43
COADchr1164200201Nonsense_MutationNAE385*0.11
COADchr1164203484Missense_MutationnovelA474V0.45
COADchr1164203447Splice_Regionnovel0.26
ESCAchr11641862595'UTRnovel0.35
ESCAchr1164202904Missense_MutationnovelP425L0.11
GBMchr1164194246Nonsense_MutationnovelR93*0.38
GBMchr1164197375Missense_MutationnovelM259I0.13
HNSCchr1164200168Splice_SitenovelX374_splice0.43
HNSCchr1164195742Missense_MutationnovelP201S0.3
HNSCchr1164197298Missense_Mutationrs149913210D234N0.12
HNSCchr1164203484Missense_MutationnovelA474V0.5
KIRPchr11642041863'UTRnovel0.51
LAMLchr1164200183Missense_MutationnovelA379T0.05
LGGchr1164193110SilentnovelA14A0.37
LGGchr11642041823'UTRnovel0.38
LIHCchr1164197571Missense_MutationnovelR293Q0.12
LIHCchr1164195803Missense_MutationnovelN221S0.42
LIHCchr11641861185'UTRnovel0.46
LIHCchr1164197517Missense_MutationNAY275C0.2
LUADchr1164200180Nonsense_MutationNAQ378*0.13
LUADchr1164193281Missense_MutationnovelW71C0.36
LUADchr11642042693'UTRnovel0.13
LUADchr1164203560Missense_MutationNAM499I0.09
LUADchr1164195854Intronnovel0.1
LUADchr1164197573Missense_MutationNAE294Q0.19
LUADchr1164200032SilentNAQ372Q0.15
LUADchr1164203564Missense_MutationNAD501N0.15
LUADchr1164197292Missense_MutationNAG232R0.36
LUADchr1164194196Missense_MutationNAS76L0.22
LUSCchr11642041553'UTRnovel0.46
LUSCchr1164193117Missense_Mutationrs769617573V17M0.1
LUSCchr1164203584Missense_MutationnovelI507M0.09
LUSCchr1164197549Missense_Mutationrs762737538I286V0.44
LUSCchr1164195666SilentNAI175I0.26
LUSCchr1164193105Nonsense_MutationnovelK13*0.18
LUSCchr1164195774SilentnovelP211P0.33
LUSCchr1164197281Missense_MutationnovelE228V0.26
LUSCchr1164200225Missense_MutationnovelD393H0.2
LUSCchr1164195698Missense_MutationNAD186V0.14
LUSCchr1164200244Missense_Mutationrs780822146N399S0.31
OVchr1164195847Intronnovel0.04
OVchr1164202886Missense_MutationNAE419V0.14
OVchr1164194195Frame_Shift_InsnovelS76Cfs*140.08
OVchr1164194200SilentNAR77R0.17
OVchr1164204060Missense_MutationnovelL522F0.11
OVchr1164194595Nonsense_MutationNAR160*0.45
OVchr1164194506Missense_MutationnovelM130R0.17
OVchr1164195852Intronnovel0.49
OVchr1164193156Frame_Shift_InsnovelA30Vfs*420.06
PAADchr1164203578SilentnovelR505R0.29
PAADchr1164194210Missense_MutationnovelA81T0.18
PAADchr1164203153Silentrs2070232A437A0.21
READchr1164197512Silentrs774373870G273G0.16
READchr1164204092Missense_MutationnovelK533R0.17
READchr1164197552Nonsense_MutationnovelE287*0.46
SARCchr11641861595'UTRnovel0.08
SARCchr1164197971SilentnovelQ340Q0.1
SARCchr11642044093'UTRnovel0.74
SKCMchr1164203508Missense_MutationNAP482L0.16
SKCMchr1164203494Silentrs768299155N477N0.23
SKCMchr1164203495Missense_MutationnovelR478W0.23
SKCMchr1164195773Missense_MutationnovelP211Q0.42
SKCMchr1164194251SilentnovelT94T0.28
SKCMchr1164197948Missense_MutationnovelP333S0.23
STADchr1164197967Missense_MutationnovelC339Y0.05
STADchr1164193196Missense_MutationNAN43S0.04
STADchr1164197340Missense_MutationnovelY248H0.15
STADchr1164195820Splice_Regionnovel0.16
STADchr1164194482Missense_MutationNAR122I0.27
STADchr1164203493Missense_MutationNAN477S0.14
STADchr1164203140Missense_MutationNAR433Q0.14
STADchr1164197582Nonsense_MutationNAR297*0.29
UCECchr1164194595Nonsense_MutationNAR160*0.37
UCECchr1164197357SilentNAE253E0.49
UCECchr1164203621Missense_MutationnovelE520K0.56
UCECchr11642043233'UTRrs7618326310.33
UCECchr1164197558Missense_MutationnovelG289R0.39
UCECchr1164203545Missense_MutationnovelE494D0.33
UCECchr11642041533'UTRnovel0.33
UCECchr1164193129Missense_Mutationrs764983786D21N0.16
UCECchr1164195860Intronnovel0.2
UCECchr1164194191Splice_RegionnovelG74G0.09
UCECchr11642044093'UTRnovel0.53
UCECchr1164195860Intronnovel0.08
UCECchr1164203201Missense_MutationnovelK453N0.39
UCECchr1164194478Splice_SiteNAX121_splice0.34
UCECchr1164203180Missense_MutationnovelK446N0.2
UCECchr11642041533'UTRnovel0.12
UCECchr1164194589Nonsense_MutationnovelQ158*0.11
UCECchr11642044093'UTRnovel0.33
UCECchr1164195865Intronnovel0.17
UCECchr1164203500Silentrs773881149H479H0.32
UCECchr1164197361Missense_MutationNAD255H0.34
UCECchr1164197865Missense_MutationnovelR305Q0.34
UCECchr1164194574Missense_MutationnovelR153W0.49
UCECchr1164204118Missense_Mutationrs766923089I542V0.46
UCECchr11642044093'UTRnovel0.34
UCECchr11642044093'UTRnovel0.37
UCECchr11642044093'UTRnovel0.39
UCECchr1164203188Missense_MutationnovelD449G0.38
UCECchr1164195865Intronnovel0.3
UCECchr11642041533'UTRnovel0.48
UCECchr1164197522Nonsense_MutationnovelK277*0.42
UCECchr11642044093'UTRnovel0.32
UCECchr1164197547Missense_Mutationrs775263263A285V0.08
UCECchr1164204051Splice_Regionnovel0.29
UCECchr1164194260Missense_MutationnovelE97D0.38
UCECchr11642041803'UTRrs1451100880.35
UCECchr1164197512Silentrs774373870G273G0.2
UCECchr1164204063SilentnovelK523K0.05
UCECchr11642044093'UTRnovel0.36
UCECchr1164200285Missense_MutationnovelA413T0.2
UCECchr1164194505Missense_MutationnovelM130V0.39
UCECchr1164197330SilentnovelA244A0.24
UCECchr1164197922Missense_MutationnovelN324S0.18
UCECchr11642041293'UTRnovel0.24
UCECchr1164194241Missense_MutationNAA91D0.29
UCECchr11642041393'UTRnovel0.17
UCECchr11642044093'UTRnovel0.44
UCECchr1164193134SilentnovelD22D0.33
UCECchr1164193214Missense_MutationnovelA49V0.41
UVMchr1164204073Missense_MutationnovelI527V0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.19570.018342
TGCTDEL0.71330.21504
UCSAMP0.250.0089022

Survival Analysis
CancerP-value Q-value
SARC0.0037

Kaplan-Meier Survival Analysis

MESO0.00017

Kaplan-Meier Survival Analysis

ACC0.002

Kaplan-Meier Survival Analysis

HNSC0.00012

Kaplan-Meier Survival Analysis

PRAD0.01

Kaplan-Meier Survival Analysis

BRCA0.0074

Kaplan-Meier Survival Analysis

ESCA0.017

Kaplan-Meier Survival Analysis

KIRP0.00053

Kaplan-Meier Survival Analysis

PAAD0.029

Kaplan-Meier Survival Analysis

BLCA0.023

Kaplan-Meier Survival Analysis

CESC0.025

Kaplan-Meier Survival Analysis

LAML0.0001

Kaplan-Meier Survival Analysis

KICH0.01

Kaplan-Meier Survival Analysis

UCEC0.043

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LUAD0.0018

Kaplan-Meier Survival Analysis

UVM0.0024

Kaplan-Meier Survival Analysis

OV0.031

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000168439 (Gene tree)
Gene ID
10963
Gene Symbol
STIP1
Alias
HOP|STI1
Full Name
stress induced phosphoprotein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
19,277 bases
Position
chr11:64,185,272-64,204,548
Accession
11387
RBP type
non-canonical RBP
Summary
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
2410268Identification of a 60-kDa phosphoprotein that binds stored messenger RNA of Xenopus oocytes.Eur J Biochem1985 Jul 1Dearsly AL-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000537479STIP1-205601--- (aa)--
ENST00000544739STIP1-212562--- (aa)--
ENST00000538497STIP1-206582--- (aa)--
ENST00000540736STIP1-209399--- (aa)--
ENST00000540501STIP1-208880--- (aa)--
ENST00000543847STIP1-211772-ENSP00000442704236 (aa)-F5H783
ENST00000358794STIP1-2032743-ENSP00000351646590 (aa)-P31948
ENST00000305218STIP1-2012196-ENSP00000305958543 (aa)-P31948
ENST00000540887STIP1-210877-ENSP00000443416137 (aa)-H0YGI8
ENST00000355603STIP1-202528--- (aa)--
ENST00000536973STIP1-204738-ENSP00000441036138 (aa)-F5GXD8
ENST00000538945STIP1-2071900-ENSP00000445957519 (aa)-P31948
Gene Model
Click here to download ENSG00000168439's gene model file
Pathways
Pathway IDPathway NameSource
hsa05020Prion diseasesKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000168439Attention Deficit Disorder with Hyperactivity4E-621784300
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000168439rs116071651164196475?Attention deficit hyperactivity disorder21784300EFO_0003888
ENSG00000168439rs22366471164197133?Reaction time29844566[0.0057-0.0126] unit increase0.0091312EFO_0008393
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168439's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000168439STIP110097.422ENSMUSG00000024966Stip110097.422Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding20029029.21044950.21170051.21360678.23349634.23431407.24880080.25036637.27353360.28330616.IPIFunction
GO:0005634nucleus16130169.TASComponent
GO:0005794Golgi apparatus1569099.TASComponent
GO:0005829cytosol-TASComponent
GO:0008022protein C-terminus binding-IEAFunction
GO:0030544Hsp70 protein binding-IEAFunction
GO:0032991protein-containing complex23349634.IDAComponent
GO:0051087chaperone binding-IEAFunction
GO:0051879Hsp90 protein binding21873635.IBAFunction
GO:0051879Hsp90 protein binding29127155.IPIFunction
GO:0098761cellular response to interleukin-7-IEAProcess
GO:0101031chaperone complex29127155.IDAComponent
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