EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18413751Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.Cancer Res2008 Apr 15Hu CMdoi: 10.1158/0008-5472.CAN-07-3069.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BRCAchr2241680289SilentNAG90G0.13
BRCAchr22416760843'UTRrs2007646960.28
BRCAchr2241685796Missense_MutationNAL71P0.41
CESCchr2241680226Splice_Regionrs7618814580.19
CESCchr2241678617Silentrs188663113D121D0.39
COADchr2241678617Silentrs188663113D121D0.32
ESCAchr2241678532Missense_Mutationrs762448283R150C0.15
GBMchr2241678510Missense_MutationnovelQ157L0.22
GBMchr2241676177Missense_MutationnovelD197N0.25
GBMchr2241678484Frame_Shift_DelnovelQ166Sfs*30.42
GBMchr2241678474Missense_MutationnovelK169T0.09
HNSCchr2241678461SilentnovelL173L0.11
LIHCchr22416760343'UTRnovel0.33
OVchr2241678544Missense_MutationnovelF146I0.09
PAADchr2241685824Missense_MutationnovelD62N0.2
PRADchr2241685822SilentnovelD62D0.35
READchr2241680300Missense_MutationnovelL87M0.48
SARCchr2241676165Missense_MutationnovelT201A0.52
SKCMchr22416760973'UTRnovel0.5
STADchr2241678617Silentrs188663113D121D0.07
THCAchr2241678538Missense_MutationNAH148N0.45
UCECchr22416760693'UTRnovel0.38
UCECchr2241676146Missense_MutationnovelL207P0.5
UCECchr2241678502Missense_MutationnovelA160T0.34
UCECchr2241680265SilentnovelY98Y0.4
UCECchr2241678644Missense_MutationnovelF112L0.57
UCECchr2241680265SilentnovelY98Y0.15
UCECchr2241676191Missense_MutationNAR192H0.43
UCECchr2241680317Missense_MutationnovelP81L0.31
UCECchr2241680277Silentrs774620496V94V0.36
UCECchr2241676193Silentrs758962690I191I0.16
UCECchr2241680265SilentnovelY98Y0.26
UCECchr2241678546Missense_Mutationrs766664417A145V0.46
UCECchr2241678531Missense_Mutationrs149828739R150H0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.22220.032456
BLCADEL0.4242.0711e-36
BRCADEL0.21482.4898e-11
CESCDEL0.34583.4658e-41
HNSCDEL0.21651.278e-25
KIRCDEL0.09285.6049e-16
KIRPDEL0.03825.174e-05
LGGDEL0.11891.4015e-20
LIHCDEL0.12970.0022356
LUSCDEL0.25951.3904e-19
OVDEL0.25567.0161e-09
PAADAMP0.05980.1091
PAADDEL0.04350.2014
SARCDEL0.38917.1647e-24
TGCTDEL0.07330.062762
THCADEL0.0240.040844
UCECDEL0.07980.00045104
UVMDEL0.0250.024639

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.0002

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

SKCM0.0082

Kaplan-Meier Survival Analysis

LUSC0.013

Kaplan-Meier Survival Analysis

PAAD0.019

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.0089

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

UVM0.00022

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000168393 (Gene tree)
Gene ID
1841
Gene Symbol
DTYMK
Alias
CDC8|TYMK|TMPK
Full Name
deoxythymidylate kinase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
11,250 bases
Position
chr2:241,675,742-241,686,991
Accession
3061
RBP type
non-canonical RBP
Summary
(Deoxythymidylate Kinase) is a Protein Coding gene. Diseases associated with DTYMK include Gaucher Disease, Type Iii. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and thymidylate kinase activity. An important paralog of this gene is CMPK2.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
14671117The genome of canarypox virus.J Virol2004 JanTulman ER-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000305784DTYMK-2011232-ENSP00000304802212 (aa)-P23919
ENST00000400770DTYMK-2021089-ENSP0000038358183 (aa)-G5E9E9
ENST00000420144DTYMK-203575-ENSP00000387379192 (aa)-H7BZ20
ENST00000432348DTYMK-204926-ENSP00000410647101 (aa)-H7C3A4
ENST00000493095DTYMK-207322--- (aa)--
ENST00000464603DTYMK-206890--- (aa)--
ENST00000445261DTYMK-205518-ENSP00000408939170 (aa)-H7C312
Gene Model
Click here to download ENSG00000168393's gene model file
Pathways
Pathway IDPathway NameSource
hsa00240Pyrimidine metabolismKEGG
hsa01100Metabolic pathwaysKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168393's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000168393DTYMK9939.450WBGene00011272dtmk-19739.450Caenorhabditis_elegans
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004550nucleoside diphosphate kinase activity21873635.IBAFunction
GO:0004798thymidylate kinase activity21873635.IBAFunction
GO:0004798thymidylate kinase activity8845311.IDAFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005739mitochondrion21873635.IBAComponent
GO:0005758mitochondrial intermembrane space-IEAComponent
GO:0005759mitochondrial matrix-IEAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0006165nucleoside diphosphate phosphorylation-IEAProcess
GO:0006227dUDP biosynthetic process21873635.IBAProcess
GO:0006233dTDP biosynthetic process21873635.IBAProcess
GO:0006235dTTP biosynthetic process21873635.IBAProcess
GO:0006235dTTP biosynthetic process-IEAProcess
GO:0008283cell proliferation8024690.TASProcess
GO:0009041uridylate kinase activity21873635.IBAFunction
GO:0015949nucleobase-containing small molecule interconversion-TASProcess
GO:0043627response to estrogen-IEAProcess
GO:0045445myoblast differentiation-IEAProcess
GO:0046686response to cadmium ion-IEAProcess
GO:0046940nucleoside monophosphate phosphorylation-IEAProcess
GO:0071363cellular response to growth factor stimulus-IEAProcess
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