EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23086647	[Expression of RRM1 and ERCC1 genes in tumor tissues and peripheral blood lymphocytes of advanced non-small cell lung cancer].	Zhejiang Da Xue Xue Bao Yi Xue Ban	2012 Sep	Zhang GB	-
23155271	Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer.	Anticancer Res	2012 Nov	Pesta M	-
19552012	[ERCC1 and RRM1 genes in lung cancer].	Rev Port Pneumol	2009 Jul-Aug	Carvalho L	-
28411237	Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy.	J Biol Chem	2017 Jun 2	Lou M	doi: 10.1074/jbc.M117.783365
28624910	Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?	J Cancer Res Clin Oncol	2017 Aug	Mannargudi MB	doi: 10.1007/s00432-017-2457-8
20467918	ERCC1, RRM1 and BRCA1 mRNA expression levels and clinical outcome of advanced non-small cell lung cancer.	Med Oncol	2011 Dec	Su C	doi: 10.1007/s12032-010-9553-9
24591771	First-line gemcitabine plus cisplatin in nonsmall cell lung cancer patients.	Dis Markers	2014	Li Y	doi: 10.1155/2014/960458
24578158	Association of novel gene polymorphisms RRM1 -756T>C and -269 C>A with breast cancer.	J Clin Lab Anal	2014 Jul	Chen DR	doi: 10.1002/jcla.21682
12687015	RRM1-induced metastasis suppression through PTEN-regulated pathways.	Oncogene	2003 Apr 10	Gautam A	-
15172981	An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines.	Cancer Res	2004 Jun 1	Davidson JD	-
26542178	Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer.	Clin Transl Oncol	2016 Aug	Lafuente-Sanchis A	doi: 10.1007/s12094-015-1440-6
23803067	mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS and TUBB3 in postoperative patients with non-small cell lung cancer.	Asian Pac J Cancer Prev	2013	Han Y	-
24861915	Investigation of the association of hRRM1 and p53R2 gene polymorphisms in head and neck squamous cell carcinomas.	Med Oncol	2014 Jul	Orhan KS	doi: 10.1007/s12032-014-0012-x
26637889	High RRM1 Expression Is Associated with Adverse Outcome in Patients with Cisplatin/Vinorelbine-treated Malignant Pleural Mesothelioma.	Anticancer Res	2015 Dec	Zimling ZG	-
25497672	RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization.	Mol Cell Endocrinol	2015 Feb 5	Germano A	doi: 10.1016/j.mce.2014.11.027
26323924	The genotype of ribonucleotidereductase M1 -269C > A is associated with the response to platinum-based chemotherapy and as a prognostic biomarker in advanced nonsmall cell lung cancer.	J Cancer Res Ther	2015 Aug	Xu XL	doi: 10.4103/0973-1482.163839.
21370501	RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum.	J Zhejiang Univ Sci B	2011 Mar	Wang LR	doi: 10.1631/jzus.B1000197.
25837929	Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors.	J Pharmacol Sci	2015 Mar	Minami K	doi: 10.1016/j.jphs.2015.01.006
14729598	In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase.	Cancer Res	2004 Jan 1	Shao J	-
20211060	[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines].	Zhonghua Zhong Liu Za Zhi	2010 Jan	Liu XQ	-
25638032	Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis.	Tumour Biol	2015 Jun	Qi H	doi: 10.1007/s13277-015-3137-4
19543324	Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma.	Oncogene	2009 Aug 13	Akita H	doi: 10.1038/onc.2009.158
17131328	Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer.	Int J Cancer	2007 Mar 15	Nakahira S	-
21424698	A randomized phase II of gemcitabine and sorafenib versus sorafenib alone in patients with metastatic pancreatic cancer.	Invest New Drugs	2012 Jun	El-Khoueiry AB	doi: 10.1007/s10637-011-9658-9
26718430	Investigation of some DNA repair genes association in non small cell lung cancer.	Cell Mol Biol (Noisy-le-grand)	2015 Dec 19	Coskunpinar E	-
24155212	Expression of RRM1 and RRM2 as a novel prognostic marker in advanced non-small cell lung cancer receiving chemotherapy.	Tumour Biol	2014 Mar	Wang L	doi: 10.1007/s13277-013-1255-4
23552804	Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysis.	Int J Gynecol Cancer	2013 May	Kunos CA	doi: 10.1097/IGC.0b013e31828b4eb5.
26650486	The relationship between RRM1 gene polymorphisms and effectiveness of gemcitabine-based first-line chemotherapy in advanced NSCLC patient.	Clin Transl Oncol	2016 Sep	Mlak R	doi: 10.1007/s12094-015-1461-1
23922955	Ribonucleotide reductase large subunit M1 predicts poor survival due to modulation of proliferative and invasive ability of gastric cancer.	PLoS One	2013 Jul 29	Wang Q	doi: 10.1371/journal.pone.0070191
21264835	Prognostic roles of human equilibrative transporter 1 (hENT-1) and ribonucleoside reductase subunit M1 (RRM1) in resected pancreatic cancer.	Cancer	2011 Jul 15	Kim R	doi: 10.1002/cncr.25883
17602053	An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.	Oncologist	2007 Jun	Rha SY	-
24361227	Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy.	Eur J Cancer	2014 Mar	Lee SY	doi: 10.1016/j.ejca.2013.11.028
21642870	Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum.	J Thorac Oncol	2011 Aug	Ryu JS	doi: 10.1097/JTO.0b013e3182208e26.
20226083	RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy.	J Hematol Oncol	2010 Mar 13	Dong S	doi: 10.1186/1756-8722-3-10.
23991987	Predictive and prognostic roles of ribonucleotide reductase M1 in patients with pancreatic cancer treated with gemcitabine: a meta-analysis.	Asian Pac J Cancer Prev	2013	Zhang X	-
19304340	Polymorphisms of the ribonucleotide reductase M1 gene and sensitivity to platin-based chemotherapy in non-small cell lung cancer.	Lung Cancer	2009 Dec	Feng JF	doi: 10.1016/j.lungcan.2009.02.015
27908619	Correlation of DNA Repair Gene Polymorphisms With Clinical Outcome in Patients With Locally Advanced Non-Small-Cell Lung Cancer Receiving Induction Chemotherapy Followed by Surgery.	Clin Lung Cancer	2017 Mar	Santarpia M	doi: 10.1016/j.cllc.2016.08.007
28507282	P53 suppresses ribonucleotide reductase via inhibiting mTORC1.	Oncotarget	2017 Jun 20	He Z	doi: 10.18632/oncotarget.17440.
27587543	Polymorphisms in cancer-related pathway genes and lung cancer.	Eur Respir J	2016 Oct	Lee SY	doi: 10.1183/13993003.02040-2015
29214667	Effect of ribonucleotide reductase M1 expression on overall survival in patients with pancreatic cancer receiving gemcitabine chemotherapy: A literature-based meta-analysis.	J Clin Pharm Ther	2018 Apr	Han QL	doi: 10.1111/jcpt.12655
28066957	Overexpression of ribonucleotide reductase subunit M1 protein predicts shorter survival in metastatic bladder cancer patients treated with gemcitabine-containing combination chemotherapy.	Int J Urol	2017 Mar	Matsumura N	doi: 10.1111/iju.13274

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	4121763	Missense_Mutation	novel	Q346E	0.21
BLCA	chr11	4106154	Missense_Mutation	NA	D73H	0.33
BLCA	chr11	4106210	Missense_Mutation	NA	K91N	0.39
BLCA	chr11	4121756	Missense_Mutation	novel	E343D	0.08
BLCA	chr11	4102012	Silent	novel	V13V	0.21
BRCA	chr11	4106188	Missense_Mutation	NA	S84C	0.5
BRCA	chr11	4095019	Missense_Mutation	novel	V3L	0.12
BRCA	chr11	4111974	Missense_Mutation	NA	E188Q	0.18
BRCA	chr11	4119950	Intron	novel		0.13
BRCA	chr11	4112025	Missense_Mutation	NA	L205F	0.23
BRCA	chr11	4122210	Silent	novel	L370L	0.04
BRCA	chr11	4132396	Missense_Mutation	NA	R627H	0.25
CESC	chr11	4121706	Missense_Mutation	NA	D327Y	0.3
CESC	chr11	4118408	Missense_Mutation	novel	G247R	0.09
CESC	chr11	4109641	Splice_Region	novel		0.32
CESC	chr11	4138295	Nonsense_Mutation	NA	S764*	0.31
CHOL	chr11	4127054	Missense_Mutation	rs72555793	R497H	0.17
COAD	chr11	4138258	Missense_Mutation	novel	L752V	0.14
COAD	chr11	4127060	Missense_Mutation	NA	R499H	0.35
COAD	chr11	4106190	Missense_Mutation	novel	N85D	0.17
COAD	chr11	4138222	Missense_Mutation	NA	R740W	0.1
COAD	chr11	4121706	Missense_Mutation	NA	D327Y	0.18
COAD	chr11	4135260	Missense_Mutation	novel	G727D	0.2
COAD	chr11	4121720	Silent	rs750572935	A331A	0.35
GBM	chr11	4119903	Missense_Mutation	novel	R284Q	0.18
GBM	chr11	4121605	Missense_Mutation	novel	R293H	0.51
GBM	chr11	4112024	Silent	novel	T204T	0.4
GBM	chr11	4138434	3'UTR	novel		0.32
HNSC	chr11	4121631	Missense_Mutation	novel	E302Q	0.27
HNSC	chr11	4119962	Intron	novel		0.11
HNSC	chr11	4111624	Missense_Mutation	novel	L157F	0.27
KIRC	chr11	4111953	Missense_Mutation	NA	E181K	0.13
KIRP	chr11	4123253	Nonsense_Mutation	novel	Q397*	0.45
KIRP	chr11	4122220	Missense_Mutation	novel	S373T	0.38
LAML	chr11	4106174	Silent	rs769263947	A79A	0.25
LGG	chr11	4123270	Silent	novel	T402T	0.17
LGG	chr11	4102012	Silent	novel	V13V	0.08
LGG	chr11	4127075	Missense_Mutation	novel	G504E	0.37
LGG	chr11	4127163	Missense_Mutation	novel	E533D	0.45
LGG	chr11	4138291	Missense_Mutation	NA	V763I	0.24
LIHC	chr11	4138353	Silent	novel	N783N	0.2
LIHC	chr11	4106062	Missense_Mutation	novel	K42R	0.19
LIHC	chr11	4119906	Missense_Mutation	novel	Y285C	0.23
LIHC	chr11	4121760	Missense_Mutation	NA	N345Y	0.42
LIHC	chr11	4127130	Silent	novel	A522A	0.47
LIHC	chr11	4138525	3'UTR	novel		0.24
LUAD	chr11	4135129	Silent	NA	V683V	0.4
LUAD	chr11	4112037	Missense_Mutation	novel	G209R	0.07
LUAD	chr11	4121608	Missense_Mutation	novel	P294L	0.13
LUAD	chr11	4106191	In_Frame_Del	novel	L86_H87del	0.16
LUAD	chr11	4102019	Missense_Mutation	novel	D16H	0.21
LUAD	chr11	4102037	Missense_Mutation	novel	I22F	0.47
LUAD	chr11	4111913	Silent	NA	P167P	0.21
LUAD	chr11	4111631	Missense_Mutation	NA	N160H	0.22
LUAD	chr11	4133630	Missense_Mutation	NA	Q658L	0.52
LUSC	chr11	4111609	Silent	novel	E152E	0.38
LUSC	chr11	4133602	Missense_Mutation	NA	G649C	0.28
MESO	chr11	4111618	Silent	novel	Y155Y	0.4
OV	chr11	4123269	Missense_Mutation	NA	T402I	0.49
PAAD	chr11	4107524	Missense_Mutation	novel	A126T	0.19
PAAD	chr11	4121604	Missense_Mutation	novel	R293C	0.07
PRAD	chr11	4135230	Splice_Site	novel	X717_splice	0.09
PRAD	chr11	4109679	Silent	NA	F141F	0.31
READ	chr11	4118424	Missense_Mutation	NA	V252E	0.33
READ	chr11	4127060	Missense_Mutation	NA	R499H	0.36
SKCM	chr11	4135232	Missense_Mutation	NA	G718S	0.44
SKCM	chr11	4132422	Splice_Site	novel	X635_splice	0.55
SKCM	chr11	4132347	Silent	NA	L611L	0.2
SKCM	chr11	4127060	Missense_Mutation	NA	R499H	0.4
SKCM	chr11	4126751	Missense_Mutation	NA	F463Y	0.41
SKCM	chr11	4106191	Missense_Mutation	NA	N85S	0.46
SKCM	chr11	4106070	Nonsense_Mutation	novel	Q45*	0.34
SKCM	chr11	4123239	Missense_Mutation	novel	A392V	0.21
STAD	chr11	4127060	Missense_Mutation	NA	R499H	0.31
STAD	chr11	4135238	Missense_Mutation	NA	L720V	0.11
STAD	chr11	4129133	Silent	novel	L584L	0.29
STAD	chr11	4112018	Silent	NA	S202S	0.04
STAD	chr11	4118445	Missense_Mutation	NA	G259D	0.13
STAD	chr11	4138292	Missense_Mutation	NA	V763A	0.17
STAD	chr11	4123199	Missense_Mutation	NA	R379C	0.09
UCEC	chr11	4121665	Missense_Mutation	NA	D313G	0.34
UCEC	chr11	4138308	Missense_Mutation	NA	E768D	0.25
UCEC	chr11	4132319	Silent	novel	P601P	0.41
UCEC	chr11	4106064	Missense_Mutation	novel	V43L	0.28
UCEC	chr11	4121732	Silent	rs144644370	P335P	0.59
UCEC	chr11	4126729	Missense_Mutation	novel	T456P	0.42
UCEC	chr11	4106181	Missense_Mutation	novel	A82T	0.14
UCEC	chr11	4135123	Missense_Mutation	novel	K681N	0.53
UCEC	chr11	4138196	Missense_Mutation	novel	G731D	0.08
UCEC	chr11	4106144	Silent	novel	T69T	0.18
UCEC	chr11	4126831	Nonsense_Mutation	novel	E490*	0.07
UCEC	chr11	4102025	Missense_Mutation	novel	I18F	0.3
UCEC	chr11	4106169	Missense_Mutation	novel	A78T	0.32
UCEC	chr11	4122200	Missense_Mutation	novel	E366D	0.06
UCEC	chr11	4126787	Missense_Mutation	rs754509608	R475Q	0.36
UCEC	chr11	4118365	Silent	novel	Y232Y	0.21
UCEC	chr11	4123272	Missense_Mutation	novel	P403L	0.43
UCEC	chr11	4138544	3'UTR	novel		0.37
UCEC	chr11	4132297	Missense_Mutation	novel	R594I	0.15
UCEC	chr11	4121709	Missense_Mutation	novel	L328I	0.44
UCEC	chr11	4126824	Silent	rs572098942	P487P	0.3
UCEC	chr11	4138212	Missense_Mutation	novel	M736I	0.21
UCEC	chr11	4129077	Missense_Mutation	novel	L566I	0.27
UCEC	chr11	4138539	3'UTR	novel		0.26
UCEC	chr11	4121605	Missense_Mutation	novel	R293H	0.39
UCEC	chr11	4109679	Missense_Mutation	novel	F141L	0.21
UCEC	chr11	4111952	Missense_Mutation	novel	K180N	0.33
UCEC	chr11	4118445	Missense_Mutation	NA	G259D	0.3
UCEC	chr11	4127141	Missense_Mutation	novel	L526S	0.41
UCEC	chr11	4138226	Missense_Mutation	novel	T741I	0.48
UCEC	chr11	4132396	Missense_Mutation	NA	R627H	0.42
UCEC	chr11	4138621	3'UTR	novel		0.5
UCEC	chr11	4121706	Missense_Mutation	NA	D327Y	0.05
UCEC	chr11	4122162	Missense_Mutation	novel	N354H	0.06
UCEC	chr11	4127159	Missense_Mutation	novel	F532S	0.14
UCEC	chr11	4106087	Silent	novel	G50G	0.27
UCEC	chr11	4135129	Silent	novel	V683V	0.1
UCEC	chr11	4121708	Silent	NA	D327D	0.36
UCEC	chr11	4126784	Missense_Mutation	novel	V474A	0.33
UCEC	chr11	4123294	Silent	novel	S410S	0.4
UCEC	chr11	4121606	Splice_Region	novel	R293R	0.34
UCS	chr11	4102041	Frame_Shift_Del	novel	*K24Afs11**	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.2949	0.02701
ESCA	AMP	0.1196	0.018342
GBM	DEL	0.1664	0.0048476
HNSC	DEL	0.2433	0.00051729
PAAD	DEL	0.1087	0.022808
PCPG	AMP	0.0309	0.23196
PCPG	DEL	0.3395	0.00064285
TGCT	DEL	0.5467	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.00073	Kaplan-Meier Survival Analysis
STAD	0.0089	Kaplan-Meier Survival Analysis
MESO	0.00017	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.042	Kaplan-Meier Survival Analysis
KIRP	0.015	Kaplan-Meier Survival Analysis
COAD	0.0034	Kaplan-Meier Survival Analysis
PAAD	0.0021	Kaplan-Meier Survival Analysis
PCPG	0.015	Kaplan-Meier Survival Analysis
BLCA	0.018	Kaplan-Meier Survival Analysis
READ	0.015	Kaplan-Meier Survival Analysis
KICH	0.0059	Kaplan-Meier Survival Analysis
LIHC	0.00084	Kaplan-Meier Survival Analysis
LGG	0.022	Kaplan-Meier Survival Analysis
LUAD	0.0058	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000167325 (Gene tree)
Gene ID: 6240
Gene Symbol: RRM1
Alias: N
Full Name: ribonucleotide reductase catalytic subunit M1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 44,321 bases
Position: chr11:4,094,561-4,138,881
Accession: 10451
Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23793387	The RRM1 domain of the poly(A)-binding protein from Saccharomyces cerevisiae is critical to control of mRNA deadenylation.	Mol Genet Genomics	2013 Sep	Zhang C	doi: 10.1007/s00438-013-0759-3
28348170	Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.	RNA	2017 Jun	van Roon AM	doi: 10.1261/rna.059378.116
16170373	Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma.	Oncogene	2005 Nov 24	Datta K	-
23129761	Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition.	J Biol Chem	2013 Jan 4	Liang C	doi: 10.1074/jbc.M112.401323
10499800	Recognition of polyadenylate RNA by the poly(A)-binding protein.	Cell	1999 Sep 17	Deo RC	-
14973222	ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.	Nucleic Acids Res	2004 Feb 18	Singh G	-
22761693	Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.	PLoS One	2012	Dammer EB	doi: 10.1371/journal.pone.0038658
21788335	Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue.	RNA	2011 Sep	Qiu ZR	doi: 10.1261/rna.2792011
25488812	Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.	Nucleic Acids Res	2015 Jan	Martino L	doi: 10.1093/nar/gku1287
26697894	Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors.	Plant Physiol	2016 Feb	Stankovic N	doi: 10.1104/pp.15.01338
25784696	Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure.	MBio	2015 Mar 17	Naguleswaran A	doi: 10.1128/mBio.00114-15.
15811912	The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.	RNA	2005 May	Kwan SS	-
20947024	Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1.	Structure	2010 Oct 13	Teplova M	doi: 10.1016/j.str.2010.06.018.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000533495	RRM1-213	2381	-	ENSP00000436377	75 (aa)	-	E9PP77
ENST00000526865	RRM1-204	562	-	-	- (aa)	-	-
ENST00000534285	RRM1-214	2075	-	ENSP00000431464	570 (aa)	-	E9PL69
ENST00000532170	RRM1-210	3166	-	ENSP00000435656	69 (aa)	-	E9PJ62
ENST00000528442	RRM1-205	783	-	ENSP00000432555	130 (aa)	-	H0YCY7
ENST00000528470	RRM1-206	579	-	-	- (aa)	-	-
ENST00000529109	RRM1-207	448	-	-	- (aa)	-	-
ENST00000531591	RRM1-209	639	-	-	- (aa)	-	-
ENST00000300738	RRM1-201	3076	-	ENSP00000300738	792 (aa)	-	P23921
ENST00000526304	RRM1-202	514	-	-	- (aa)	-	-
ENST00000533349	RRM1-212	2863	-	ENSP00000434069	37 (aa)	-	E9PRY9
ENST00000532710	RRM1-211	549	-	-	- (aa)	-	-
ENST00000530368	RRM1-208	332	-	-	- (aa)	-	-
ENST00000526350	RRM1-203	583	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000167325's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00240	Pyrimidine metabolism	KEGG
hsa00480	Glutathione metabolism	KEGG
hsa00983	Drug metabolism - other enzymes	KEGG
hsa01100	Metabolic pathways	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167325	rs7947605	11	4130066	?	Mean corpuscular hemoglobin	29403010	[0.019-0.038] unit increase novel	0.02827	EFO_0004527
ENSG00000167325	rs11030967	11	4107890	T	Red cell distribution width	27863252	[0.021-0.035] unit decrease	0.02771503	EFO_0005192
ENSG00000167325	rs11030967	11	4107890	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000167325	rs11030976	11	4108629	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167325's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167325	RRM1	93	85.714	WBGene00004391	rnr-1	99	73.924	Caenorhabditis_elegans
ENSG00000167325	RRM1	100	83.784	FBgn0011703	RnrL	99	74.157	Drosophila_melanogaster
ENSG00000167325	RRM1	93	81.429	YER070W	RNR1	85	67.105	Saccharomyces_cerevisiae
ENSG00000167325	RRM1	93	80.000	YIL066C	RNR3	87	66.711	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	-	IEA	Process
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	21873635.	IBA	Function
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	-	ISS	Function
GO:0005515	protein binding	17726094.21336276.22632967.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005635	nuclear envelope	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005971	ribonucleoside-diphosphate reductase complex	21873635.	IBA	Component
GO:0006206	pyrimidine nucleobase metabolic process	-	IEA	Process
GO:0006260	DNA replication	-	IEA	Process
GO:0008584	male gonad development	-	IEA	Process
GO:0009263	deoxyribonucleotide biosynthetic process	21873635.	IBA	Process
GO:0009263	deoxyribonucleotide biosynthetic process	-	ISS	Process
GO:0010212	response to ionizing radiation	-	IEA	Process
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	Process
GO:0021846	cell proliferation in forebrain	-	IEA	Process
GO:0042802	identical protein binding	17726094.21336276.25416956.	IPI	Function
GO:0042995	cell projection	-	IEA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0051290	protein heterotetramerization	-	IEA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0060041	retina development in camera-type eye	-	IEA	Process
GO:0097718	disordered domain specific binding	-	IEA	Function

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.