EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23086647[Expression of RRM1 and ERCC1 genes in tumor tissues and peripheral blood lymphocytes of advanced non-small cell lung cancer].Zhejiang Da Xue Xue Bao Yi Xue Ban2012 SepZhang GB-
23155271Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer.Anticancer Res2012 NovPesta M-
19552012[ERCC1 and RRM1 genes in lung cancer].Rev Port Pneumol2009 Jul-AugCarvalho L-
28411237Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy.J Biol Chem2017 Jun 2Lou Mdoi: 10.1074/jbc.M117.783365
28624910Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?J Cancer Res Clin Oncol2017 AugMannargudi MBdoi: 10.1007/s00432-017-2457-8
20467918ERCC1, RRM1 and BRCA1 mRNA expression levels and clinical outcome of advanced non-small cell lung cancer.Med Oncol2011 DecSu Cdoi: 10.1007/s12032-010-9553-9
24591771First-line gemcitabine plus cisplatin in nonsmall cell lung cancer patients.Dis Markers2014Li Ydoi: 10.1155/2014/960458
24578158Association of novel gene polymorphisms RRM1 -756T>C and -269 C>A with breast cancer.J Clin Lab Anal2014 JulChen DRdoi: 10.1002/jcla.21682
12687015RRM1-induced metastasis suppression through PTEN-regulated pathways.Oncogene2003 Apr 10Gautam A-
15172981An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines.Cancer Res2004 Jun 1Davidson JD-
26542178Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer.Clin Transl Oncol2016 AugLafuente-Sanchis Adoi: 10.1007/s12094-015-1440-6
23803067mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS and TUBB3 in postoperative patients with non-small cell lung cancer.Asian Pac J Cancer Prev2013Han Y-
24861915Investigation of the association of hRRM1 and p53R2 gene polymorphisms in head and neck squamous cell carcinomas.Med Oncol2014 JulOrhan KSdoi: 10.1007/s12032-014-0012-x
26637889High RRM1 Expression Is Associated with Adverse Outcome in Patients with Cisplatin/Vinorelbine-treated Malignant Pleural Mesothelioma.Anticancer Res2015 DecZimling ZG-
25497672RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization.Mol Cell Endocrinol2015 Feb 5Germano Adoi: 10.1016/j.mce.2014.11.027
26323924The genotype of ribonucleotidereductase M1 -269C > A is associated with the response to platinum-based chemotherapy and as a prognostic biomarker in advanced nonsmall cell lung cancer.J Cancer Res Ther2015 AugXu XLdoi: 10.4103/0973-1482.163839.
21370501RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum.J Zhejiang Univ Sci B2011 MarWang LRdoi: 10.1631/jzus.B1000197.
25837929Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors.J Pharmacol Sci2015 MarMinami Kdoi: 10.1016/j.jphs.2015.01.006
14729598In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase.Cancer Res2004 Jan 1Shao J-
20211060[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines].Zhonghua Zhong Liu Za Zhi2010 JanLiu XQ-
25638032Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis.Tumour Biol2015 JunQi Hdoi: 10.1007/s13277-015-3137-4
19543324Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma.Oncogene2009 Aug 13Akita Hdoi: 10.1038/onc.2009.158
17131328Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer.Int J Cancer2007 Mar 15Nakahira S-
21424698A randomized phase II of gemcitabine and sorafenib versus sorafenib alone in patients with metastatic pancreatic cancer.Invest New Drugs2012 JunEl-Khoueiry ABdoi: 10.1007/s10637-011-9658-9
26718430Investigation of some DNA repair genes association in non small cell lung cancer.Cell Mol Biol (Noisy-le-grand)2015 Dec 19Coskunpinar E-
24155212Expression of RRM1 and RRM2 as a novel prognostic marker in advanced non-small cell lung cancer receiving chemotherapy.Tumour Biol2014 MarWang Ldoi: 10.1007/s13277-013-1255-4
23552804Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysis.Int J Gynecol Cancer2013 MayKunos CAdoi: 10.1097/IGC.0b013e31828b4eb5.
26650486The relationship between RRM1 gene polymorphisms and effectiveness of gemcitabine-based first-line chemotherapy in advanced NSCLC patient.Clin Transl Oncol2016 SepMlak Rdoi: 10.1007/s12094-015-1461-1
23922955Ribonucleotide reductase large subunit M1 predicts poor survival due to modulation of proliferative and invasive ability of gastric cancer.PLoS One2013 Jul 29Wang Qdoi: 10.1371/journal.pone.0070191
21264835Prognostic roles of human equilibrative transporter 1 (hENT-1) and ribonucleoside reductase subunit M1 (RRM1) in resected pancreatic cancer.Cancer2011 Jul 15Kim Rdoi: 10.1002/cncr.25883
17602053An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.Oncologist2007 JunRha SY-
24361227Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy.Eur J Cancer2014 MarLee SYdoi: 10.1016/j.ejca.2013.11.028
21642870Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum.J Thorac Oncol2011 AugRyu JSdoi: 10.1097/JTO.0b013e3182208e26.
20226083RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy.J Hematol Oncol2010 Mar 13Dong Sdoi: 10.1186/1756-8722-3-10.
23991987Predictive and prognostic roles of ribonucleotide reductase M1 in patients with pancreatic cancer treated with gemcitabine: a meta-analysis.Asian Pac J Cancer Prev2013Zhang X-
19304340Polymorphisms of the ribonucleotide reductase M1 gene and sensitivity to platin-based chemotherapy in non-small cell lung cancer.Lung Cancer2009 DecFeng JFdoi: 10.1016/j.lungcan.2009.02.015
27908619Correlation of DNA Repair Gene Polymorphisms With Clinical Outcome in Patients With Locally Advanced Non-Small-Cell Lung Cancer Receiving Induction Chemotherapy Followed by Surgery.Clin Lung Cancer2017 MarSantarpia Mdoi: 10.1016/j.cllc.2016.08.007
28507282P53 suppresses ribonucleotide reductase via inhibiting mTORC1.Oncotarget2017 Jun 20He Zdoi: 10.18632/oncotarget.17440.
27587543Polymorphisms in cancer-related pathway genes and lung cancer.Eur Respir J2016 OctLee SYdoi: 10.1183/13993003.02040-2015
29214667Effect of ribonucleotide reductase M1 expression on overall survival in patients with pancreatic cancer receiving gemcitabine chemotherapy: A literature-based meta-analysis.J Clin Pharm Ther2018 AprHan QLdoi: 10.1111/jcpt.12655
28066957Overexpression of ribonucleotide reductase subunit M1 protein predicts shorter survival in metastatic bladder cancer patients treated with gemcitabine-containing combination chemotherapy.Int J Urol2017 MarMatsumura Ndoi: 10.1111/iju.13274

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr114121763Missense_MutationnovelQ346E0.21
BLCAchr114106154Missense_MutationNAD73H0.33
BLCAchr114106210Missense_MutationNAK91N0.39
BLCAchr114121756Missense_MutationnovelE343D0.08
BLCAchr114102012SilentnovelV13V0.21
BRCAchr114106188Missense_MutationNAS84C0.5
BRCAchr114095019Missense_MutationnovelV3L0.12
BRCAchr114111974Missense_MutationNAE188Q0.18
BRCAchr114119950Intronnovel0.13
BRCAchr114112025Missense_MutationNAL205F0.23
BRCAchr114122210SilentnovelL370L0.04
BRCAchr114132396Missense_MutationNAR627H0.25
CESCchr114121706Missense_MutationNAD327Y0.3
CESCchr114118408Missense_MutationnovelG247R0.09
CESCchr114109641Splice_Regionnovel0.32
CESCchr114138295Nonsense_MutationNAS764*0.31
CHOLchr114127054Missense_Mutationrs72555793R497H0.17
COADchr114138258Missense_MutationnovelL752V0.14
COADchr114127060Missense_MutationNAR499H0.35
COADchr114106190Missense_MutationnovelN85D0.17
COADchr114138222Missense_MutationNAR740W0.1
COADchr114121706Missense_MutationNAD327Y0.18
COADchr114135260Missense_MutationnovelG727D0.2
COADchr114121720Silentrs750572935A331A0.35
GBMchr114119903Missense_MutationnovelR284Q0.18
GBMchr114121605Missense_MutationnovelR293H0.51
GBMchr114112024SilentnovelT204T0.4
GBMchr1141384343'UTRnovel0.32
HNSCchr114121631Missense_MutationnovelE302Q0.27
HNSCchr114119962Intronnovel0.11
HNSCchr114111624Missense_MutationnovelL157F0.27
KIRCchr114111953Missense_MutationNAE181K0.13
KIRPchr114123253Nonsense_MutationnovelQ397*0.45
KIRPchr114122220Missense_MutationnovelS373T0.38
LAMLchr114106174Silentrs769263947A79A0.25
LGGchr114123270SilentnovelT402T0.17
LGGchr114102012SilentnovelV13V0.08
LGGchr114127075Missense_MutationnovelG504E0.37
LGGchr114127163Missense_MutationnovelE533D0.45
LGGchr114138291Missense_MutationNAV763I0.24
LIHCchr114138353SilentnovelN783N0.2
LIHCchr114106062Missense_MutationnovelK42R0.19
LIHCchr114119906Missense_MutationnovelY285C0.23
LIHCchr114121760Missense_MutationNAN345Y0.42
LIHCchr114127130SilentnovelA522A0.47
LIHCchr1141385253'UTRnovel0.24
LUADchr114135129SilentNAV683V0.4
LUADchr114112037Missense_MutationnovelG209R0.07
LUADchr114121608Missense_MutationnovelP294L0.13
LUADchr114106191In_Frame_DelnovelL86_H87del0.16
LUADchr114102019Missense_MutationnovelD16H0.21
LUADchr114102037Missense_MutationnovelI22F0.47
LUADchr114111913SilentNAP167P0.21
LUADchr114111631Missense_MutationNAN160H0.22
LUADchr114133630Missense_MutationNAQ658L0.52
LUSCchr114111609SilentnovelE152E0.38
LUSCchr114133602Missense_MutationNAG649C0.28
MESOchr114111618SilentnovelY155Y0.4
OVchr114123269Missense_MutationNAT402I0.49
PAADchr114107524Missense_MutationnovelA126T0.19
PAADchr114121604Missense_MutationnovelR293C0.07
PRADchr114135230Splice_SitenovelX717_splice0.09
PRADchr114109679SilentNAF141F0.31
READchr114118424Missense_MutationNAV252E0.33
READchr114127060Missense_MutationNAR499H0.36
SKCMchr114135232Missense_MutationNAG718S0.44
SKCMchr114132422Splice_SitenovelX635_splice0.55
SKCMchr114132347SilentNAL611L0.2
SKCMchr114127060Missense_MutationNAR499H0.4
SKCMchr114126751Missense_MutationNAF463Y0.41
SKCMchr114106191Missense_MutationNAN85S0.46
SKCMchr114106070Nonsense_MutationnovelQ45*0.34
SKCMchr114123239Missense_MutationnovelA392V0.21
STADchr114127060Missense_MutationNAR499H0.31
STADchr114135238Missense_MutationNAL720V0.11
STADchr114129133SilentnovelL584L0.29
STADchr114112018SilentNAS202S0.04
STADchr114118445Missense_MutationNAG259D0.13
STADchr114138292Missense_MutationNAV763A0.17
STADchr114123199Missense_MutationNAR379C0.09
UCECchr114121665Missense_MutationNAD313G0.34
UCECchr114138308Missense_MutationNAE768D0.25
UCECchr114132319SilentnovelP601P0.41
UCECchr114106064Missense_MutationnovelV43L0.28
UCECchr114121732Silentrs144644370P335P0.59
UCECchr114126729Missense_MutationnovelT456P0.42
UCECchr114106181Missense_MutationnovelA82T0.14
UCECchr114135123Missense_MutationnovelK681N0.53
UCECchr114138196Missense_MutationnovelG731D0.08
UCECchr114106144SilentnovelT69T0.18
UCECchr114126831Nonsense_MutationnovelE490*0.07
UCECchr114102025Missense_MutationnovelI18F0.3
UCECchr114106169Missense_MutationnovelA78T0.32
UCECchr114122200Missense_MutationnovelE366D0.06
UCECchr114126787Missense_Mutationrs754509608R475Q0.36
UCECchr114118365SilentnovelY232Y0.21
UCECchr114123272Missense_MutationnovelP403L0.43
UCECchr1141385443'UTRnovel0.37
UCECchr114132297Missense_MutationnovelR594I0.15
UCECchr114121709Missense_MutationnovelL328I0.44
UCECchr114126824Silentrs572098942P487P0.3
UCECchr114138212Missense_MutationnovelM736I0.21
UCECchr114129077Missense_MutationnovelL566I0.27
UCECchr1141385393'UTRnovel0.26
UCECchr114121605Missense_MutationnovelR293H0.39
UCECchr114109679Missense_MutationnovelF141L0.21
UCECchr114111952Missense_MutationnovelK180N0.33
UCECchr114118445Missense_MutationNAG259D0.3
UCECchr114127141Missense_MutationnovelL526S0.41
UCECchr114138226Missense_MutationnovelT741I0.48
UCECchr114132396Missense_MutationNAR627H0.42
UCECchr1141386213'UTRnovel0.5
UCECchr114121706Missense_MutationNAD327Y0.05
UCECchr114122162Missense_MutationnovelN354H0.06
UCECchr114127159Missense_MutationnovelF532S0.14
UCECchr114106087SilentnovelG50G0.27
UCECchr114135129SilentnovelV683V0.1
UCECchr114121708SilentNAD327D0.36
UCECchr114126784Missense_MutationnovelV474A0.33
UCECchr114123294SilentnovelS410S0.4
UCECchr114121606Splice_RegionnovelR293R0.34
UCSchr114102041Frame_Shift_DelnovelK24Afs*110.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.29490.02701
ESCAAMP0.11960.018342
GBMDEL0.16640.0048476
HNSCDEL0.24330.00051729
PAADDEL0.10870.022808
PCPGAMP0.03090.23196
PCPGDEL0.33950.00064285
TGCTDEL0.54670.21504

Survival Analysis
CancerP-value Q-value
THYM0.00073

Kaplan-Meier Survival Analysis

STAD0.0089

Kaplan-Meier Survival Analysis

MESO0.00017

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

PRAD0.042

Kaplan-Meier Survival Analysis

KIRP0.015

Kaplan-Meier Survival Analysis

COAD0.0034

Kaplan-Meier Survival Analysis

PAAD0.0021

Kaplan-Meier Survival Analysis

PCPG0.015

Kaplan-Meier Survival Analysis

BLCA0.018

Kaplan-Meier Survival Analysis

READ0.015

Kaplan-Meier Survival Analysis

KICH0.0059

Kaplan-Meier Survival Analysis

LIHC0.00084

Kaplan-Meier Survival Analysis

LGG0.022

Kaplan-Meier Survival Analysis

LUAD0.0058

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000167325 (Gene tree)
Gene ID
6240
Gene Symbol
RRM1
Alias
N
Full Name
ribonucleotide reductase catalytic subunit M1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
44,321 bases
Position
chr11:4,094,561-4,138,881
Accession
10451
RBP type
non-canonical RBP
Summary
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23793387The RRM1 domain of the poly(A)-binding protein from Saccharomyces cerevisiae is critical to control of mRNA deadenylation.Mol Genet Genomics2013 SepZhang Cdoi: 10.1007/s00438-013-0759-3
28348170Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.RNA2017 Junvan Roon AMdoi: 10.1261/rna.059378.116
16170373Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma.Oncogene2005 Nov 24Datta K-
23129761Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition.J Biol Chem2013 Jan 4Liang Cdoi: 10.1074/jbc.M112.401323
10499800Recognition of polyadenylate RNA by the poly(A)-binding protein.Cell1999 Sep 17Deo RC-
14973222ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.Nucleic Acids Res2004 Feb 18Singh G-
22761693Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.PLoS One2012Dammer EBdoi: 10.1371/journal.pone.0038658
21788335Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue.RNA2011 SepQiu ZRdoi: 10.1261/rna.2792011
25488812Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.Nucleic Acids Res2015 JanMartino Ldoi: 10.1093/nar/gku1287
26697894Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors.Plant Physiol2016 FebStankovic Ndoi: 10.1104/pp.15.01338
25784696Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure.MBio2015 Mar 17Naguleswaran Adoi: 10.1128/mBio.00114-15.
15811912The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.RNA2005 MayKwan SS-
20947024Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1.Structure2010 Oct 13Teplova Mdoi: 10.1016/j.str.2010.06.018.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000533495RRM1-2132381-ENSP0000043637775 (aa)-E9PP77
ENST00000526865RRM1-204562--- (aa)--
ENST00000534285RRM1-2142075-ENSP00000431464570 (aa)-E9PL69
ENST00000532170RRM1-2103166-ENSP0000043565669 (aa)-E9PJ62
ENST00000528442RRM1-205783-ENSP00000432555130 (aa)-H0YCY7
ENST00000528470RRM1-206579--- (aa)--
ENST00000529109RRM1-207448--- (aa)--
ENST00000531591RRM1-209639--- (aa)--
ENST00000300738RRM1-2013076-ENSP00000300738792 (aa)-P23921
ENST00000526304RRM1-202514--- (aa)--
ENST00000533349RRM1-2122863-ENSP0000043406937 (aa)-E9PRY9
ENST00000532710RRM1-211549--- (aa)--
ENST00000530368RRM1-208332--- (aa)--
ENST00000526350RRM1-203583--- (aa)--
Gene Model
Click here to download ENSG00000167325's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa00240Pyrimidine metabolismKEGG
hsa00480Glutathione metabolismKEGG
hsa00983Drug metabolism - other enzymesKEGG
hsa01100Metabolic pathwaysKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000167325rs7947605114130066?Mean corpuscular hemoglobin29403010[0.019-0.038] unit increase novel0.02827EFO_0004527
ENSG00000167325rs11030967114107890TRed cell distribution width27863252[0.021-0.035] unit decrease0.02771503EFO_0005192
ENSG00000167325rs11030967114107890?Red cell distribution width30595370EFO_0005192
ENSG00000167325rs11030976114108629?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167325's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000167325RRM19385.714WBGene00004391rnr-19973.924Caenorhabditis_elegans
ENSG00000167325RRM110083.784FBgn0011703RnrL9974.157Drosophila_melanogaster
ENSG00000167325RRM19381.429YER070WRNR18567.105Saccharomyces_cerevisiae
ENSG00000167325RRM19380.000YIL066CRNR38766.711Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000278mitotic cell cycle-IEAProcess
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor21873635.IBAFunction
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-ISSFunction
GO:0005515protein binding17726094.21336276.22632967.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005635nuclear envelope-IEAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005971ribonucleoside-diphosphate reductase complex21873635.IBAComponent
GO:0006206pyrimidine nucleobase metabolic process-IEAProcess
GO:0006260DNA replication-IEAProcess
GO:0008584male gonad development-IEAProcess
GO:0009263deoxyribonucleotide biosynthetic process21873635.IBAProcess
GO:0009263deoxyribonucleotide biosynthetic process-ISSProcess
GO:0010212response to ionizing radiation-IEAProcess
GO:0015949nucleobase-containing small molecule interconversion-TASProcess
GO:0021846cell proliferation in forebrain-IEAProcess
GO:0042802identical protein binding17726094.21336276.25416956.IPIFunction
GO:0042995cell projection-IEAComponent
GO:0043025neuronal cell body-IEAComponent
GO:0051290protein heterotetramerization-IEAProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0060041retina development in camera-type eye-IEAProcess
GO:0097718disordered domain specific binding-IEAFunction
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us