EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30319007	Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.	Transcription	2019 Apr	Greenleaf AL	doi: 10.1080/21541264.2018.1535211
26787835	Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications.	Cancer Res	2016 Apr 1	Popova T	doi: 10.1158/0008-5472.CAN-15-2128
28334900	CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.	Nucleic Acids Res	2017 Jun 20	Tien JF	doi: 10.1093/nar/gkx187.
29133620	Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.	Mol Cancer Ther	2018 Jan	Naidoo K	doi: 10.1158/1535-7163.MCT-17-0760

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	39530956	Silent	novel	V1371V	0.29
BLCA	chr17	39530956	Silent	novel	V1371V	0.46
BLCA	chr17	39462352	Frame_Shift_Del	novel	*E95Rfs29**	0.17
BLCA	chr17	39530812	Missense_Mutation	NA	L1323F	0.51
BLCA	chr17	39530973	Missense_Mutation	novel	S1377L	0.29
BLCA	chr17	39463101	Missense_Mutation	NA	R344W	0.54
BLCA	chr17	39471433	Missense_Mutation	novel	S534F	0.15
BLCA	chr17	39471207	Missense_Mutation	novel	D459H	0.17
BLCA	chr17	39494645	Frame_Shift_Del	novel	*E791Kfs30**	0.17
BLCA	chr17	39462838	Nonsense_Mutation	novel	S256*	0.38
BLCA	chr17	39490708	Nonsense_Mutation	novel	Q695*	0.26
BLCA	chr17	39492829	Silent	novel	I729I	0.48
BLCA	chr17	39520062	Missense_Mutation	rs201479472	E1024K	0.21
BLCA	chr17	39462514	Missense_Mutation	NA	S148L	0.19
BLCA	chr17	39492773	Missense_Mutation	novel	E711K	0.2
BLCA	chr17	39525981	Missense_Mutation	novel	S1142C	0.51
BLCA	chr17	39524699	Missense_Mutation	novel	E1041K	0.17
BLCA	chr17	39471317	Missense_Mutation	novel	L495F	0.14
BLCA	chr17	39471673	Missense_Mutation	novel	S614C	0.13
BLCA	chr17	39462363	Missense_Mutation	NA	E98K	0.27
BLCA	chr17	39471243	Missense_Mutation	NA	E471Q	0.09
BLCA	chr17	39471528	Silent	NA	L566L	0.21
BLCA	chr17	39511572	Missense_Mutation	novel	P904A	0.35
BLCA	chr17	39511567	Missense_Mutation	novel	R902Q	0.06
BLCA	chr17	39471022	Missense_Mutation	novel	A397V	0.08
BLCA	chr17	39462636	Missense_Mutation	NA	E189K	0.24
BLCA	chr17	39471317	Missense_Mutation	novel	L495F	0.05
BLCA	chr17	39492761	Missense_Mutation	rs754901174	P707S	0.14
BLCA	chr17	39471075	Missense_Mutation	novel	M415V	0.31
BLCA	chr17	39511534	Missense_Mutation	novel	P891L	0.08
BLCA	chr17	39462018	5'Flank	novel		0.5
BLCA	chr17	39494569	Missense_Mutation	NA	E765G	0.18
BLCA	chr17	39530829	Missense_Mutation	NA	S1329F	0.44
BRCA	chr17	39525986	Missense_Mutation	NA	P1144S	0.12
BRCA	chr17	39462131	Frame_Shift_Del	NA	*L21Afs10**	0.42
BRCA	chr17	39511567	Missense_Mutation	NA	R902P	0.27
BRCA	chr17	39462006	5'Flank	novel		0.73
BRCA	chr17	39515778	Missense_Mutation	rs773007495	N939S	0.21
BRCA	chr17	39524858	Missense_Mutation	NA	V1094L	0.5
BRCA	chr17	39509762	Splice_Site	NA	X889_splice	0.22
BRCA	chr17	39462809	Nonsense_Mutation	NA	Y246*	0.58
BRCA	chr17	39517485	Silent	novel	I964I	0.07
BRCA	chr17	39471294	Nonsense_Mutation	NA	E488*	0.49
BRCA	chr17	39492802	Silent	novel	G720G	0.05
BRCA	chr17	39525992	Missense_Mutation	novel	M1146L	0.05
BRCA	chr17	39530979	Missense_Mutation	rs778399102	S1379C	0.08
BRCA	chr17	39515738	Missense_Mutation	NA	L926I	0.16
BRCA	chr17	39462381	Silent	novel	R104R	0.1
BRCA	chr17	39462327	Missense_Mutation	NA	D86N	0.44
BRCA	chr17	39471356	Silent	NA	L508L	0.18
BRCA	chr17	39462193	Missense_Mutation	NA	K41T	0.19
CESC	chr17	39530812	Missense_Mutation	NA	L1323F	0.23
CESC	chr17	39526052	Missense_Mutation	novel	Q1166E	0.15
CESC	chr17	39524783	Missense_Mutation	NA	E1069Q	0.16
CESC	chr17	39462496	Missense_Mutation	novel	S142L	0.09
CESC	chr17	39520061	Silent	rs758539836	V1023V	0.28
CESC	chr17	39462463	Missense_Mutation	novel	E131G	0.53
CESC	chr17	39492845	Missense_Mutation	novel	E735K	0.19
CESC	chr17	39471394	Missense_Mutation	novel	S521L	0.44
CESC	chr17	39462236	Missense_Mutation	NA	L55F	0.32
CESC	chr17	39531337	3'UTR	novel		0.3
CESC	chr17	39471510	Missense_Mutation	novel	L560F	0.18
CESC	chr17	39471569	Silent	rs775559482	S579S	0.39
CESC	chr17	39471636	Nonsense_Mutation	NA	Q602*	0.46
CESC	chr17	39490565	Missense_Mutation	novel	E647G	0.59
CESC	chr17	39462888	Nonsense_Mutation	novel	Q273*	0.44
CESC	chr17	39511614	Missense_Mutation	NA	D918N	0.32
CESC	chr17	39494543	Missense_Mutation	novel	K756N	0.25
CESC	chr17	39524699	Missense_Mutation	novel	E1041Q	0.11
CESC	chr17	39471471	Nonsense_Mutation	novel	Q547*	0.31
CESC	chr17	39530812	Missense_Mutation	NA	L1323F	0.41
CHOL	chr17	39530901	Missense_Mutation	novel	T1353I	0.43
COAD	chr17	39531426	3'UTR	novel		0.27
COAD	chr17	39530639	Frame_Shift_Del	NA	*P1267Lfs27**	0.33
COAD	chr17	39471479	Silent	novel	P549P	0.19
COAD	chr17	39471336	Missense_Mutation	NA	D502Y	0.36
COAD	chr17	39526067	Missense_Mutation	novel	E1171K	0.22
COAD	chr17	39494592	Missense_Mutation	NA	R773C	0.07
COAD	chr17	39511531	Missense_Mutation	NA	R890H	0.26
COAD	chr17	39471466	Missense_Mutation	novel	P545L	0.31
COAD	chr17	39519986	Missense_Mutation	novel	D998E	0.15
COAD	chr17	39492806	Missense_Mutation	NA	R722C	0.18
COAD	chr17	39490612	Missense_Mutation	rs749022057	R663C	0.4
COAD	chr17	39462042	5'UTR	novel		0.33
COAD	chr17	39511531	Missense_Mutation	NA	R890H	0.42
COAD	chr17	39471095	Missense_Mutation	NA	K421N	0.27
COAD	chr17	39492794	Missense_Mutation	novel	D718N	0.46
COAD	chr17	39471441	Frame_Shift_Del	NA	*P538Lfs72**	0.39
COAD	chr17	39511531	Missense_Mutation	NA	R890H	0.19
COAD	chr17	39530834	Nonsense_Mutation	NA	R1331*	0.48
COAD	chr17	39511532	Silent	novel	R890R	0.4
COAD	chr17	39530740	Silent	novel	A1299A	0.31
COAD	chr17	39531109	Missense_Mutation	novel	K1422N	0.17
COAD	chr17	39515753	Missense_Mutation	NA	T931A	0.23
COAD	chr17	39520017	Missense_Mutation	NA	C1009R	0.69
COAD	chr17	39471406	Frame_Shift_Del	novel	*P526Lfs84**	0.16
COAD	chr17	39530648	Frame_Shift_Del	NA	*G1271Dfs23**	0.14
COAD	chr17	39462391	Missense_Mutation	novel	R107H	0.08
COAD	chr17	39531054	Missense_Mutation	novel	R1404H	0.18
COAD	chr17	39462340	Missense_Mutation	novel	K90R	0.09
COAD	chr17	39530648	Frame_Shift_Del	NA	*G1271Dfs23**	0.38
COAD	chr17	39524775	Missense_Mutation	novel	S1066Y	0.37
COAD	chr17	39530698	Silent	novel	D1285D	0.4
COAD	chr17	39490612	Missense_Mutation	rs749022057	R663C	0.24
COAD	chr17	39471435	Frame_Shift_Del	NA	*P536Hfs74**	0.37
COAD	chr17	39515766	Frame_Shift_Del	NA	*Q937Kfs9**	0.2
COAD	chr17	39530741	Missense_Mutation	rs769197936	A1300T	0.29
COAD	chr17	39490669	Frame_Shift_Del	NA	*P683Qfs70**	0.34
COAD	chr17	39492810	Missense_Mutation	novel	C723Y	0.27
DLBC	chr17	39471490	Missense_Mutation	novel	P553L	0.36
ESCA	chr17	39524699	Missense_Mutation	novel	E1041K	0.16
ESCA	chr17	39501288	Missense_Mutation	novel	L820I	0.12
ESCA	chr17	39494592	Missense_Mutation	NA	R773C	0.39
ESCA	chr17	39511588	Missense_Mutation	novel	G909V	0.92
GBM	chr17	39520038	Frame_Shift_Del	novel	*Q1016Rfs41**	0.06
GBM	chr17	39462532	Missense_Mutation	rs759709034	S154L	0.21
GBM	chr17	39517528	Nonsense_Mutation	NA	R979*	0.17
GBM	chr17	39531129	Missense_Mutation	novel	S1429F	0.18
GBM	chr17	39530945	Nonsense_Mutation	novel	Q1368*	0.12
GBM	chr17	39526057	Missense_Mutation	novel	Q1167H	0.15
GBM	chr17	39471063	Missense_Mutation	novel	A411S	0.05
GBM	chr17	39462804	Missense_Mutation	novel	D245Y	0.07
GBM	chr17	39471256	Missense_Mutation	NA	S475Y	0.21
GBM	chr17	39462462	Frame_Shift_Ins	NA	*S133Kfs24**	0.55
GBM	chr17	39530950	Silent	NA	T1369T	0.13
HNSC	chr17	39494611	Missense_Mutation	NA	R779H	0.26
HNSC	chr17	39517531	Missense_Mutation	novel	R980G	0.23
HNSC	chr17	39501432	Frame_Shift_Del	novel	*N868Ifs8**	0.33
HNSC	chr17	39471685	Missense_Mutation	novel	A618V	0.07
HNSC	chr17	39471340	Missense_Mutation	novel	S503C	0.19
HNSC	chr17	39531388	3'UTR	novel		0.43
HNSC	chr17	39530885	Missense_Mutation	novel	F1348L	0.04
KIRC	chr17	39463119	Splice_Site	NA	X349_splice	0.29
KIRC	chr17	39490571	Missense_Mutation	NA	L649R	0.15
KIRC	chr17	39524876	Missense_Mutation	NA	D1100N	0.28
KIRC	chr17	39531124	In_Frame_Ins	novel	S1427_N1428insK	0.23
KIRC	chr17	39520040	Frame_Shift_Ins	novel	*S1017Ffs5**	0.07
KIRC	chr17	39526119	Frame_Shift_Del	novel	*I1188Tfs27**	0.35
KIRC	chr17	39494593	Missense_Mutation	novel	R773H	0.17
KIRC	chr17	39524840	Nonsense_Mutation	NA	Q1088*	0.21
KIRP	chr17	39471235	Missense_Mutation	NA	L468Q	0.28
KIRP	chr17	39462927	Missense_Mutation	novel	Q286K	0.29
LGG	chr17	39471574	Missense_Mutation	NA	T581I	0.05
LGG	chr17	39515778	Missense_Mutation	rs773007495	N939S	0.08
LGG	chr17	39520015	Missense_Mutation	NA	R1008Q	0.27
LGG	chr17	39471463	Missense_Mutation	novel	P544H	0.12
LGG	chr17	39462312	Frame_Shift_Ins	novel	*F83Pfs10**	0.17
LIHC	chr17	39462955	Missense_Mutation	rs749865286	Y295C	0.33
LIHC	chr17	39462922	Missense_Mutation	rs775376309	A284V	0.14
LUAD	chr17	39511573	Missense_Mutation	novel	P904L	0.25
LUAD	chr17	39501365	Missense_Mutation	NA	E845D	0.46
LUAD	chr17	39494549	Silent	rs770270328	V758V	0.24
LUAD	chr17	39501387	Missense_Mutation	novel	K853Q	0.07
LUAD	chr17	39471106	Missense_Mutation	NA	V425A	0.15
LUAD	chr17	39471481	Frame_Shift_Ins	novel	*L551Ffs24**	0.28
LUAD	chr17	39463039	Missense_Mutation	NA	S323L	0.1
LUAD	chr17	39530942	Missense_Mutation	NA	V1367I	0.26
LUAD	chr17	39517534	Missense_Mutation	NA	R981C	0.18
LUAD	chr17	39490654	Missense_Mutation	novel	G677C	0.31
LUAD	chr17	39490655	Missense_Mutation	NA	G677D	0.32
LUAD	chr17	39462919	Missense_Mutation	rs759485356	S283L	0.08
LUAD	chr17	39463051	Missense_Mutation	rs376614675	Y327C	0.34
LUAD	chr17	39462162	Frame_Shift_Del	novel	*N31Sfs23**	0.22
LUAD	chr17	39530942	Missense_Mutation	NA	V1367L	0.19
LUAD	chr17	39520028	Silent	NA	E1012E	0.19
LUAD	chr17	39462733	Missense_Mutation	novel	R221K	0.4
LUAD	chr17	39471145	Missense_Mutation	NA	K438R	0.36
LUAD	chr17	39462864	Missense_Mutation	NA	S265R	0.08
LUSC	chr17	39524796	Missense_Mutation	novel	G1073A	0.3
LUSC	chr17	39471287	Silent	NA	E485E	0.59
LUSC	chr17	39530953	Silent	NA	L1370L	0.29
LUSC	chr17	39509760	Missense_Mutation	novel	S889C	0.17
LUSC	chr17	39471610	Missense_Mutation	novel	S593Y	0.21
LUSC	chr17	39462906	Nonsense_Mutation	novel	Y279*	0.22
LUSC	chr17	39530649	Missense_Mutation	novel	P1269L	0.04
LUSC	chr17	39471739	Nonsense_Mutation	novel	L636*	0.41
LUSC	chr17	39494526	Missense_Mutation	NA	E751K	0.16
LUSC	chr17	39471000	Missense_Mutation	novel	P390S	0.16
LUSC	chr17	39531052	Silent	NA	L1403L	0.38
LUSC	chr17	39531213	Missense_Mutation	novel	L1457R	0.3
LUSC	chr17	39462156	Missense_Mutation	novel	S29C	0.1
LUSC	chr17	39471115	Missense_Mutation	novel	P428R	0.11
LUSC	chr17	39515803	Silent	NA	L947L	0.19
LUSC	chr17	39462613	In_Frame_Del	novel	E182del	0.05
LUSC	chr17	39530929	Missense_Mutation	novel	L1362F	0.15
LUSC	chr17	39520014	Missense_Mutation	NA	R1008W	0.35
LUSC	chr17	39530630	Missense_Mutation	novel	E1263K	0.37
LUSC	chr17	39531106	Silent	novel	L1421L	0.33
LUSC	chr17	39517441	Missense_Mutation	novel	R950G	0.17
OV	chr17	39526077	Missense_Mutation	NA	A1174G	0.86
OV	chr17	39462899	Frame_Shift_Ins	novel	*Y279Lfs19**	0.75
OV	chr17	39517541	In_Frame_Del	NA	R983_E984delinsQ	0.61
OV	chr17	39470920	Nonsense_Mutation	NA	S363*	0.85
OV	chr17	39462333	Frame_Shift_Del	novel	*A88Gfs30**	0.75
OV	chr17	39519980	Missense_Mutation	NA	L996F	0.8
OV	chr17	39471205	Missense_Mutation	novel	P458L	0.06
OV	chr17	39517516	Missense_Mutation	NA	K975E	0.57
OV	chr17	39471636	Nonsense_Mutation	NA	Q602*	0.79
OV	chr17	39490583	Missense_Mutation	NA	P653L	0.58
OV	chr17	39509740	Missense_Mutation	NA	R882L	0.26
OV	chr17	39515740	Frame_Shift_Ins	NA	*E928Gfs27**	0.54
OV	chr17	39471592	Missense_Mutation	novel	S587Y	0.04
OV	chr17	39462241	Frame_Shift_Del	novel	*E59Kfs33**	0.88
OV	chr17	39520028	In_Frame_Del	NA	T1014_Q1016del	0.77
OV	chr17	39492798	Nonsense_Mutation	NA	W719*	0.49
OV	chr17	39519955	Splice_Site	novel	X988_splice	0.81
OV	chr17	39463099	Splice_Site	NA	X343_splice	0.9
OV	chr17	39526029	Nonsense_Mutation	novel	*S1158delinsRILAVYNH**	0.04
OV	chr17	39494626	Frame_Shift_Ins	NA	*S785Kfs4**	0.92
OV	chr17	39462434	Frame_Shift_Del	NA	*L122Tfs4**	0.94
PAAD	chr17	39462703	Missense_Mutation	rs778493744	K211T	0.23
PAAD	chr17	39471409	Missense_Mutation	novel	P526H	0.22
PRAD	chr17	39462720	Nonsense_Mutation	NA	K217*	0.1
PRAD	chr17	39511588	Missense_Mutation	rs538308945	G909E	0.12
PRAD	chr17	39520037	Silent	rs757636720	L1015L	0.77
PRAD	chr17	39471601	Frame_Shift_Ins	novel	*T592Dfs49**	0.35
PRAD	chr17	39490711	Nonsense_Mutation	novel	Q696*	0.38
PRAD	chr17	39494595	Missense_Mutation	novel	E774K	0.38
PRAD	chr17	39520000	Frame_Shift_Del	novel	*L1003Rfs3**	0.41
PRAD	chr17	39531180	Missense_Mutation	NA	G1446E	0.31
PRAD	chr17	39494660	Missense_Mutation	NA	D795E	0.63
PRAD	chr17	39531219	Frame_Shift_Del	NA	*G1461Afs38**	0.38
PRAD	chr17	39463095	Frame_Shift_Ins	novel	*S343Efs8**	0.19
PRAD	chr17	39501402	Missense_Mutation	NA	R858W	0.51
PRAD	chr17	39463118	Splice_Site	NA	X349_splice	0.32
PRAD	chr17	39471594	Frame_Shift_Del	novel	*T588Ifs48**	0.45
PRAD	chr17	39470879	Frame_Shift_Del	novel	*R350Qfs3**	0.11
PRAD	chr17	39462233	Frame_Shift_Del	novel	*L55Qfs32**	0.15
PRAD	chr17	39471624	Nonsense_Mutation	NA	Q598*	0.3
PRAD	chr17	39524774	Missense_Mutation	rs747832521	S1066P	0.34
READ	chr17	39524724	Missense_Mutation	rs751631029	R1049H	0.26
READ	chr17	39494610	Missense_Mutation	NA	R779C	0.44
READ	chr17	39509709	Nonsense_Mutation	NA	Q872*	0.17
READ	chr17	39531405	3'UTR	novel		0.38
READ	chr17	39470953	Missense_Mutation	NA	R374K	0.34
READ	chr17	39471256	Missense_Mutation	NA	S475Y	0.31
READ	chr17	39501341	Missense_Mutation	NA	K837N	0.26
READ	chr17	39511531	Missense_Mutation	NA	R890H	0.26
SARC	chr17	39471376	Missense_Mutation	rs750167967	P515L	0.37
SARC	chr17	39471748	Missense_Mutation	novel	D639V	0.19
SARC	chr17	39471137	Silent	novel	V435V	0.18
SKCM	chr17	39509739	Missense_Mutation	NA	R882W	0.36
SKCM	chr17	39530760	Missense_Mutation	NA	S1306F	0.22
SKCM	chr17	39471011	Silent	novel	S393S	0.36
SKCM	chr17	39517474	Missense_Mutation	NA	P961S	0.32
SKCM	chr17	39515792	Nonsense_Mutation	NA	Q944*	0.53
SKCM	chr17	39520006	Missense_Mutation	novel	P1005L	0.29
SKCM	chr17	39530761	Silent	NA	S1306S	0.07
SKCM	chr17	39471586	Missense_Mutation	NA	P585L	0.31
SKCM	chr17	39494592	Missense_Mutation	NA	R773C	0.4
SKCM	chr17	39530709	Frame_Shift_Del	NA	*Q1291Rfs3**	0.13
SKCM	chr17	39531036	Missense_Mutation	novel	P1398L	0.37
SKCM	chr17	39471535	Missense_Mutation	NA	P568L	0.36
SKCM	chr17	39494652	Missense_Mutation	NA	V793F	0.25
SKCM	chr17	39524757	Missense_Mutation	NA	P1060L	0.09
SKCM	chr17	39531319	3'UTR	novel		0.94
SKCM	chr17	39524778	Missense_Mutation	rs143648695	R1067Q	0.38
SKCM	chr17	39471466	Missense_Mutation	novel	P545L	0.27
SKCM	chr17	39462296	In_Frame_Ins	novel	D75_I76insLF	0.11
SKCM	chr17	39462297	Frame_Shift_Ins	novel	*S77Lfs19**	0.08
SKCM	chr17	39494606	Silent	NA	I777I	0.55
SKCM	chr17	39471212	Silent	novel	T460T	0.22
SKCM	chr17	39517553	Missense_Mutation	rs201661022	S987F	0.5
SKCM	chr17	39462346	Missense_Mutation	NA	D92A	0.14
SKCM	chr17	39462348	Nonsense_Mutation	NA	R93*	0.14
SKCM	chr17	39471588	Missense_Mutation	NA	P586S	0.09
SKCM	chr17	39531350	3'UTR	novel		0.26
SKCM	chr17	39530780	Missense_Mutation	NA	P1313S	0.31
SKCM	chr17	39462034	5'Flank	novel		0.41
SKCM	chr17	39525868	Silent	NA	L1104L	0.98
SKCM	chr17	39471717	Missense_Mutation	rs146621695	P629S	0.46
STAD	chr17	39517535	Missense_Mutation	NA	R981H	0.15
STAD	chr17	39531179	Nonsense_Mutation	NA	G1446*	0.05
STAD	chr17	39515738	Missense_Mutation	NA	L926I	0.05
STAD	chr17	39462051	5'UTR	novel		0.24
STAD	chr17	39492859	Silent	NA	G739G	0.29
STAD	chr17	39530707	Silent	rs780009851	S1288S	0.19
STAD	chr17	39471188	Silent	NA	K452K	0.04
STAD	chr17	39511630	Missense_Mutation	NA	G923V	0.3
STAD	chr17	39530648	Frame_Shift_Del	NA	*G1271Dfs23**	0.29
STAD	chr17	39494610	Missense_Mutation	NA	R779C	0.18
STAD	chr17	39530648	Frame_Shift_Del	NA	*G1271Dfs23**	0.22
STAD	chr17	39494611	Missense_Mutation	NA	R779H	0.18
STAD	chr17	39490669	Frame_Shift_Del	NA	*P683Qfs70**	0.28
STAD	chr17	39509740	Missense_Mutation	NA	R882Q	0.22
STAD	chr17	39511605	Missense_Mutation	NA	P915S	0.48
STAD	chr17	39494585	Silent	NA	T770T	0.25
STAD	chr17	39530909	Nonsense_Mutation	novel	R1356*	0.03
STAD	chr17	39470958	Missense_Mutation	NA	S376G	0.32
STAD	chr17	39471639	Frame_Shift_Del	novel	*P604Lfs6**	0.2
STAD	chr17	39524850	Missense_Mutation	novel	P1091L	0.29
STAD	chr17	39462898	Frame_Shift_Ins	novel	*P277Sfs21**	0.16
STAD	chr17	39525906	Missense_Mutation	NA	A1117E	0.08
STAD	chr17	39462432	Missense_Mutation	NA	D121H	0.4
STAD	chr17	39470964	Missense_Mutation	rs370304179	R378C	0.19
STAD	chr17	39490669	Frame_Shift_Del	NA	*P683Qfs70**	0.36
STAD	chr17	39525906	Missense_Mutation	NA	A1117V	0.27
THCA	chr17	39526040	Missense_Mutation	NA	E1162K	0.21
THCA	chr17	39517551	Frame_Shift_Ins	novel	*S987Rfs18**	0.1
THCA	chr17	39462070	5'UTR	novel		0.32
UCEC	chr17	39524777	Nonsense_Mutation	NA	R1067*	0.4
UCEC	chr17	39462694	Missense_Mutation	NA	K208T	0.24
UCEC	chr17	39471108	Missense_Mutation	novel	F426V	0.22
UCEC	chr17	39471256	Missense_Mutation	NA	S475Y	0.26
UCEC	chr17	39531882	3'UTR	novel		0.42
UCEC	chr17	39517551	Missense_Mutation	NA	F986L	0.44
UCEC	chr17	39463036	Missense_Mutation	novel	R322L	0.32
UCEC	chr17	39471054	Missense_Mutation	novel	A408P	0.45
UCEC	chr17	39515786	Silent	novel	L942L	0.32
UCEC	chr17	39530707	Silent	rs780009851	S1288S	0.45
UCEC	chr17	39471215	Silent	novel	E461E	0.04
UCEC	chr17	39490583	Missense_Mutation	NA	P653H	0.21
UCEC	chr17	39490655	Missense_Mutation	NA	G677D	0.45
UCEC	chr17	39471435	Missense_Mutation	rs771063488	P535S	0.52
UCEC	chr17	39470989	Missense_Mutation	novel	P386L	0.2
UCEC	chr17	39524683	Silent	novel	H1035H	0.32
UCEC	chr17	39471315	Silent	novel	L495L	0.37
UCEC	chr17	39501343	Missense_Mutation	rs748453656	S838L	0.35
UCEC	chr17	39530761	Silent	novel	S1306S	0.46
UCEC	chr17	39531934	3'UTR	novel		0.33
UCEC	chr17	39462042	5'UTR	novel		0.38
UCEC	chr17	39471252	Missense_Mutation	novel	N474H	0.27
UCEC	chr17	39471477	In_Frame_Del	NA	L554_P556del	0.31
UCEC	chr17	39492793	Silent	rs777401578	S717S	0.57
UCEC	chr17	39501402	Silent	novel	R858R	0.41
UCEC	chr17	39471212	Frame_Shift_Del	novel	*L462Cfs21**	0.38
UCEC	chr17	39462863	Missense_Mutation	novel	K264N	0.33
UCEC	chr17	39520014	Missense_Mutation	NA	R1008W	0.36
UCEC	chr17	39462244	Frame_Shift_Del	novel	*P58Qfs33**	0.12
UCEC	chr17	39494587	Missense_Mutation	novel	A771V	0.43
UCEC	chr17	39531934	3'UTR	novel		0.24
UCEC	chr17	39471247	Frame_Shift_Ins	novel	*N474Kfs12**	0.38
UCEC	chr17	39471503	Missense_Mutation	novel	I557M	0.38
UCEC	chr17	39531290	Missense_Mutation	NA	G1483R	1
UCEC	chr17	39520061	Silent	rs758539836	V1023V	0.38
UCEC	chr17	39530836	Silent	novel	R1331R	0.36
UCEC	chr17	39531238	Silent	rs770310273	S1465S	0.26
UCEC	chr17	39501402	Missense_Mutation	NA	R858W	0.48
UCEC	chr17	39462708	Missense_Mutation	NA	V213M	0.05
UCEC	chr17	39462452	Silent	novel	Q127Q	0.38
UCEC	chr17	39471489	Missense_Mutation	novel	P553T	0.09
UCEC	chr17	39490645	Nonsense_Mutation	novel	E674*	0.32
UCEC	chr17	39530709	Frame_Shift_Del	NA	*Q1291Rfs3**	0.34
UCEC	chr17	39520014	Missense_Mutation	NA	R1008W	0.04
UCEC	chr17	39511630	Missense_Mutation	NA	G923V	0.16
UCEC	chr17	39470891	Missense_Mutation	novel	M353I	0.96
UCEC	chr17	39471639	Frame_Shift_Del	novel	*P604Lfs6**	0.33
UCEC	chr17	39494653	Missense_Mutation	novel	V793A	0.71
UCEC	chr17	39511605	Missense_Mutation	NA	P915S	0.45
UCEC	chr17	39462146	Silent	novel	S25S	0.43
UCEC	chr17	39471584	Frame_Shift_Ins	novel	*S587Ffs54**	0.38
UCEC	chr17	39517457	Missense_Mutation	novel	P955H	0.36
UCEC	chr17	39524764	Silent	rs778467311	P1062P	0.11
UCEC	chr17	39531682	3'UTR	novel		0.5
UCEC	chr17	39501389	Missense_Mutation	NA	K853N	0.33
UCEC	chr17	39492807	Missense_Mutation	novel	R722H	0.15
UCEC	chr17	39509707	Missense_Mutation	novel	G871E	0.19
UCEC	chr17	39511625	Missense_Mutation	novel	S921R	0.2
UCEC	chr17	39515744	Missense_Mutation	rs267604832	E928K	0.15
UCEC	chr17	39525866	Missense_Mutation	novel	L1104I	0.22
UCEC	chr17	39526306	Missense_Mutation	novel	E1250D	0.23
UCEC	chr17	39524755	Missense_Mutation	novel	E1059D	0.48
UCEC	chr17	39490672	Missense_Mutation	NA	P683T	0.29
UCEC	chr17	39462234	Silent	NA	L55L	0.18
UCEC	chr17	39492807	Missense_Mutation	novel	R722H	0.21
UCEC	chr17	39524876	Missense_Mutation	NA	D1100N	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2889	0.0017784
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCS	DEL	0.3036	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.011	Kaplan-Meier Survival Analysis
MESO	0.011	Kaplan-Meier Survival Analysis
KIRP	0.00054	Kaplan-Meier Survival Analysis
PAAD	0.0095	Kaplan-Meier Survival Analysis
READ	0.002	Kaplan-Meier Survival Analysis
LAML	0.0031	Kaplan-Meier Survival Analysis
KICH	0.0071	Kaplan-Meier Survival Analysis
LIHC	0.012	Kaplan-Meier Survival Analysis
LGG	0.038	Kaplan-Meier Survival Analysis
THCA	0.036	Kaplan-Meier Survival Analysis
UVM	0.047	Kaplan-Meier Survival Analysis
OV	0.029	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167258 (Gene tree)
Gene ID: 51755
Gene Symbol: CDK12
Alias: CRK7|CRKR|KIAA0904|CRKRS
Full Name: cyclin dependent kinase 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 106,074 bases
Position: chr17:39,461,486-39,567,559
Accession: 24224
RBP type: non-canonical RBP
Summary: N

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25429106	Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.	J Biol Chem	2015 Jan 16	Bartkowiak B	doi: 10.1074/jbc.M114.612226
30819820	CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.	Genes Dev	2019 Apr 1	Choi SH	doi: 10.1101/gad.322339.118

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430627	CDK12-201	5918	-	ENSP00000407720	1481 (aa)	-	Q9NYV4
ENST00000581963	CDK12-207	436	-	-	- (aa)	-	-
ENST00000584336	CDK12-208	1963	-	-	- (aa)	-	-
ENST00000581593	CDK12-206	559	-	-	- (aa)	-	-
ENST00000559545	CDK12-204	586	-	-	- (aa)	-	-
ENST00000559663	CDK12-205	871	-	ENSP00000453329	159 (aa)	-	H0YLT2
ENST00000447079	CDK12-202	8336	XM_005257456	ENSP00000398880	1490 (aa)	XP_005257513	Q9NYV4
ENST00000558240	CDK12-203	555	-	-	- (aa)	-	-
ENST00000585161	CDK12-210	2036	-	-	- (aa)	-	-
ENST00000584632	CDK12-209	4165	XM_005257458	ENSP00000464641	1201 (aa)	XP_005257515	J3QSD7

Gene Model

Click here to download ENSG00000167258's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167258	Arthritis, Rheumatoid	2E-8	24390342
ENSG00000167258	Glomerular Filtration Rate	9E-6	27588450
ENSG00000167258	Forced Expiratory Volume	1E-7	28166213
ENSG00000167258	Polycystic Ovary Syndrome	1E-6	26416764
ENSG00000167258	Urine	4E-26	26352407

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167258	rs11078903	17	39475671	A	Glomerular filtration rate	27588450	[0.32-0.81] unit decrease	0.564	EFO_0005208
ENSG00000167258	rs7219014	17	39468537	A	Urinary metabolites	26352407	[NR] unit decrease	0.156	EFO_0005116
ENSG00000167258	rs12451586	17	39477582	A	Glomerular filtration rate (creatinine)	28452372	[0.007-0.0114] unit decrease	0.0092	EFO_0005208\|EFO_0004518
ENSG00000167258	rs11650776	17	39485149	A	Lung function (FEV1)	28166213	[0.017-0.037] unit increase	0.027	EFO_0004314
ENSG00000167258	rs12449852	17	39475835	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000167258	rs4795384	17	39560518	G	Estimated glomerular filtration rate	30604766	[0.2-0.59] ml/min/1.73m2 decrease	0.395	EFO_0005208

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167258's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167258	CDK12	100	90.201	ENSMUSG00000003119	Cdk12	100	90.268	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	21873635.	IBA	Component
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0001650	fibrillar center	-	IDA	Component
GO:0002944	cyclin K-CDK12 complex	22012619.	IPI	Component
GO:0004672	protein kinase activity	11683387.	IDA	Function
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0005515	protein binding	12841360.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	21873635.	IBA	Component
GO:0006368	transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0006468	protein phosphorylation	21873635.	IBA	Process
GO:0008024	cyclin/CDK positive transcription elongation factor complex	21873635.	IBA	Component
GO:0008134	transcription factor binding	21873635.	IBA	Function
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	21873635.	IBA	Function
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	20952539.	IMP	Function
GO:0008380	RNA splicing	-	ISS	Process
GO:0016607	nuclear speck	11683387.	IDA	Component
GO:0019901	protein kinase binding	-	IEA	Function
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	-	ISS	Component
GO:0030332	cyclin binding	21873635.	IBA	Function
GO:0030332	cyclin binding	22012619.	IPI	Function
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0043405	regulation of MAP kinase activity	19651820.	IMP	Process
GO:0043484	regulation of RNA splicing	-	IEA	Process
GO:0044212	transcription regulatory region DNA binding	21873635.	IBA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0046777	protein autophosphorylation	11683387.	IDA	Process
GO:0051726	regulation of cell cycle	-	IEA	Process
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	21873635.	IBA	Process
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	20952539.	IMP	Process
GO:2000737	negative regulation of stem cell differentiation	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.