EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30319007Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.Transcription2019 AprGreenleaf ALdoi: 10.1080/21541264.2018.1535211
26787835Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications.Cancer Res2016 Apr 1Popova Tdoi: 10.1158/0008-5472.CAN-15-2128
28334900CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.Nucleic Acids Res2017 Jun 20Tien JFdoi: 10.1093/nar/gkx187.
29133620Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.Mol Cancer Ther2018 JanNaidoo Kdoi: 10.1158/1535-7163.MCT-17-0760

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1739530956SilentnovelV1371V0.29
BLCAchr1739530956SilentnovelV1371V0.46
BLCAchr1739462352Frame_Shift_DelnovelE95Rfs*290.17
BLCAchr1739530812Missense_MutationNAL1323F0.51
BLCAchr1739530973Missense_MutationnovelS1377L0.29
BLCAchr1739463101Missense_MutationNAR344W0.54
BLCAchr1739471433Missense_MutationnovelS534F0.15
BLCAchr1739471207Missense_MutationnovelD459H0.17
BLCAchr1739494645Frame_Shift_DelnovelE791Kfs*300.17
BLCAchr1739462838Nonsense_MutationnovelS256*0.38
BLCAchr1739490708Nonsense_MutationnovelQ695*0.26
BLCAchr1739492829SilentnovelI729I0.48
BLCAchr1739520062Missense_Mutationrs201479472E1024K0.21
BLCAchr1739462514Missense_MutationNAS148L0.19
BLCAchr1739492773Missense_MutationnovelE711K0.2
BLCAchr1739525981Missense_MutationnovelS1142C0.51
BLCAchr1739524699Missense_MutationnovelE1041K0.17
BLCAchr1739471317Missense_MutationnovelL495F0.14
BLCAchr1739471673Missense_MutationnovelS614C0.13
BLCAchr1739462363Missense_MutationNAE98K0.27
BLCAchr1739471243Missense_MutationNAE471Q0.09
BLCAchr1739471528SilentNAL566L0.21
BLCAchr1739511572Missense_MutationnovelP904A0.35
BLCAchr1739511567Missense_MutationnovelR902Q0.06
BLCAchr1739471022Missense_MutationnovelA397V0.08
BLCAchr1739462636Missense_MutationNAE189K0.24
BLCAchr1739471317Missense_MutationnovelL495F0.05
BLCAchr1739492761Missense_Mutationrs754901174P707S0.14
BLCAchr1739471075Missense_MutationnovelM415V0.31
BLCAchr1739511534Missense_MutationnovelP891L0.08
BLCAchr17394620185'Flanknovel0.5
BLCAchr1739494569Missense_MutationNAE765G0.18
BLCAchr1739530829Missense_MutationNAS1329F0.44
BRCAchr1739525986Missense_MutationNAP1144S0.12
BRCAchr1739462131Frame_Shift_DelNAL21Afs*100.42
BRCAchr1739511567Missense_MutationNAR902P0.27
BRCAchr17394620065'Flanknovel0.73
BRCAchr1739515778Missense_Mutationrs773007495N939S0.21
BRCAchr1739524858Missense_MutationNAV1094L0.5
BRCAchr1739509762Splice_SiteNAX889_splice0.22
BRCAchr1739462809Nonsense_MutationNAY246*0.58
BRCAchr1739517485SilentnovelI964I0.07
BRCAchr1739471294Nonsense_MutationNAE488*0.49
BRCAchr1739492802SilentnovelG720G0.05
BRCAchr1739525992Missense_MutationnovelM1146L0.05
BRCAchr1739530979Missense_Mutationrs778399102S1379C0.08
BRCAchr1739515738Missense_MutationNAL926I0.16
BRCAchr1739462381SilentnovelR104R0.1
BRCAchr1739462327Missense_MutationNAD86N0.44
BRCAchr1739471356SilentNAL508L0.18
BRCAchr1739462193Missense_MutationNAK41T0.19
CESCchr1739530812Missense_MutationNAL1323F0.23
CESCchr1739526052Missense_MutationnovelQ1166E0.15
CESCchr1739524783Missense_MutationNAE1069Q0.16
CESCchr1739462496Missense_MutationnovelS142L0.09
CESCchr1739520061Silentrs758539836V1023V0.28
CESCchr1739462463Missense_MutationnovelE131G0.53
CESCchr1739492845Missense_MutationnovelE735K0.19
CESCchr1739471394Missense_MutationnovelS521L0.44
CESCchr1739462236Missense_MutationNAL55F0.32
CESCchr17395313373'UTRnovel0.3
CESCchr1739471510Missense_MutationnovelL560F0.18
CESCchr1739471569Silentrs775559482S579S0.39
CESCchr1739471636Nonsense_MutationNAQ602*0.46
CESCchr1739490565Missense_MutationnovelE647G0.59
CESCchr1739462888Nonsense_MutationnovelQ273*0.44
CESCchr1739511614Missense_MutationNAD918N0.32
CESCchr1739494543Missense_MutationnovelK756N0.25
CESCchr1739524699Missense_MutationnovelE1041Q0.11
CESCchr1739471471Nonsense_MutationnovelQ547*0.31
CESCchr1739530812Missense_MutationNAL1323F0.41
CHOLchr1739530901Missense_MutationnovelT1353I0.43
COADchr17395314263'UTRnovel0.27
COADchr1739530639Frame_Shift_DelNAP1267Lfs*270.33
COADchr1739471479SilentnovelP549P0.19
COADchr1739471336Missense_MutationNAD502Y0.36
COADchr1739526067Missense_MutationnovelE1171K0.22
COADchr1739494592Missense_MutationNAR773C0.07
COADchr1739511531Missense_MutationNAR890H0.26
COADchr1739471466Missense_MutationnovelP545L0.31
COADchr1739519986Missense_MutationnovelD998E0.15
COADchr1739492806Missense_MutationNAR722C0.18
COADchr1739490612Missense_Mutationrs749022057R663C0.4
COADchr17394620425'UTRnovel0.33
COADchr1739511531Missense_MutationNAR890H0.42
COADchr1739471095Missense_MutationNAK421N0.27
COADchr1739492794Missense_MutationnovelD718N0.46
COADchr1739471441Frame_Shift_DelNAP538Lfs*720.39
COADchr1739511531Missense_MutationNAR890H0.19
COADchr1739530834Nonsense_MutationNAR1331*0.48
COADchr1739511532SilentnovelR890R0.4
COADchr1739530740SilentnovelA1299A0.31
COADchr1739531109Missense_MutationnovelK1422N0.17
COADchr1739515753Missense_MutationNAT931A0.23
COADchr1739520017Missense_MutationNAC1009R0.69
COADchr1739471406Frame_Shift_DelnovelP526Lfs*840.16
COADchr1739530648Frame_Shift_DelNAG1271Dfs*230.14
COADchr1739462391Missense_MutationnovelR107H0.08
COADchr1739531054Missense_MutationnovelR1404H0.18
COADchr1739462340Missense_MutationnovelK90R0.09
COADchr1739530648Frame_Shift_DelNAG1271Dfs*230.38
COADchr1739524775Missense_MutationnovelS1066Y0.37
COADchr1739530698SilentnovelD1285D0.4
COADchr1739490612Missense_Mutationrs749022057R663C0.24
COADchr1739471435Frame_Shift_DelNAP536Hfs*740.37
COADchr1739515766Frame_Shift_DelNAQ937Kfs*90.2
COADchr1739530741Missense_Mutationrs769197936A1300T0.29
COADchr1739490669Frame_Shift_DelNAP683Qfs*700.34
COADchr1739492810Missense_MutationnovelC723Y0.27
DLBCchr1739471490Missense_MutationnovelP553L0.36
ESCAchr1739524699Missense_MutationnovelE1041K0.16
ESCAchr1739501288Missense_MutationnovelL820I0.12
ESCAchr1739494592Missense_MutationNAR773C0.39
ESCAchr1739511588Missense_MutationnovelG909V0.92
GBMchr1739520038Frame_Shift_DelnovelQ1016Rfs*410.06
GBMchr1739462532Missense_Mutationrs759709034S154L0.21
GBMchr1739517528Nonsense_MutationNAR979*0.17
GBMchr1739531129Missense_MutationnovelS1429F0.18
GBMchr1739530945Nonsense_MutationnovelQ1368*0.12
GBMchr1739526057Missense_MutationnovelQ1167H0.15
GBMchr1739471063Missense_MutationnovelA411S0.05
GBMchr1739462804Missense_MutationnovelD245Y0.07
GBMchr1739471256Missense_MutationNAS475Y0.21
GBMchr1739462462Frame_Shift_InsNAS133Kfs*240.55
GBMchr1739530950SilentNAT1369T0.13
HNSCchr1739494611Missense_MutationNAR779H0.26
HNSCchr1739517531Missense_MutationnovelR980G0.23
HNSCchr1739501432Frame_Shift_DelnovelN868Ifs*80.33
HNSCchr1739471685Missense_MutationnovelA618V0.07
HNSCchr1739471340Missense_MutationnovelS503C0.19
HNSCchr17395313883'UTRnovel0.43
HNSCchr1739530885Missense_MutationnovelF1348L0.04
KIRCchr1739463119Splice_SiteNAX349_splice0.29
KIRCchr1739490571Missense_MutationNAL649R0.15
KIRCchr1739524876Missense_MutationNAD1100N0.28
KIRCchr1739531124In_Frame_InsnovelS1427_N1428insK0.23
KIRCchr1739520040Frame_Shift_InsnovelS1017Ffs*50.07
KIRCchr1739526119Frame_Shift_DelnovelI1188Tfs*270.35
KIRCchr1739494593Missense_MutationnovelR773H0.17
KIRCchr1739524840Nonsense_MutationNAQ1088*0.21
KIRPchr1739471235Missense_MutationNAL468Q0.28
KIRPchr1739462927Missense_MutationnovelQ286K0.29
LGGchr1739471574Missense_MutationNAT581I0.05
LGGchr1739515778Missense_Mutationrs773007495N939S0.08
LGGchr1739520015Missense_MutationNAR1008Q0.27
LGGchr1739471463Missense_MutationnovelP544H0.12
LGGchr1739462312Frame_Shift_InsnovelF83Pfs*100.17
LIHCchr1739462955Missense_Mutationrs749865286Y295C0.33
LIHCchr1739462922Missense_Mutationrs775376309A284V0.14
LUADchr1739511573Missense_MutationnovelP904L0.25
LUADchr1739501365Missense_MutationNAE845D0.46
LUADchr1739494549Silentrs770270328V758V0.24
LUADchr1739501387Missense_MutationnovelK853Q0.07
LUADchr1739471106Missense_MutationNAV425A0.15
LUADchr1739471481Frame_Shift_InsnovelL551Ffs*240.28
LUADchr1739463039Missense_MutationNAS323L0.1
LUADchr1739530942Missense_MutationNAV1367I0.26
LUADchr1739517534Missense_MutationNAR981C0.18
LUADchr1739490654Missense_MutationnovelG677C0.31
LUADchr1739490655Missense_MutationNAG677D0.32
LUADchr1739462919Missense_Mutationrs759485356S283L0.08
LUADchr1739463051Missense_Mutationrs376614675Y327C0.34
LUADchr1739462162Frame_Shift_DelnovelN31Sfs*230.22
LUADchr1739530942Missense_MutationNAV1367L0.19
LUADchr1739520028SilentNAE1012E0.19
LUADchr1739462733Missense_MutationnovelR221K0.4
LUADchr1739471145Missense_MutationNAK438R0.36
LUADchr1739462864Missense_MutationNAS265R0.08
LUSCchr1739524796Missense_MutationnovelG1073A0.3
LUSCchr1739471287SilentNAE485E0.59
LUSCchr1739530953SilentNAL1370L0.29
LUSCchr1739509760Missense_MutationnovelS889C0.17
LUSCchr1739471610Missense_MutationnovelS593Y0.21
LUSCchr1739462906Nonsense_MutationnovelY279*0.22
LUSCchr1739530649Missense_MutationnovelP1269L0.04
LUSCchr1739471739Nonsense_MutationnovelL636*0.41
LUSCchr1739494526Missense_MutationNAE751K0.16
LUSCchr1739471000Missense_MutationnovelP390S0.16
LUSCchr1739531052SilentNAL1403L0.38
LUSCchr1739531213Missense_MutationnovelL1457R0.3
LUSCchr1739462156Missense_MutationnovelS29C0.1
LUSCchr1739471115Missense_MutationnovelP428R0.11
LUSCchr1739515803SilentNAL947L0.19
LUSCchr1739462613In_Frame_DelnovelE182del0.05
LUSCchr1739530929Missense_MutationnovelL1362F0.15
LUSCchr1739520014Missense_MutationNAR1008W0.35
LUSCchr1739530630Missense_MutationnovelE1263K0.37
LUSCchr1739531106SilentnovelL1421L0.33
LUSCchr1739517441Missense_MutationnovelR950G0.17
OVchr1739526077Missense_MutationNAA1174G0.86
OVchr1739462899Frame_Shift_InsnovelY279Lfs*190.75
OVchr1739517541In_Frame_DelNAR983_E984delinsQ0.61
OVchr1739470920Nonsense_MutationNAS363*0.85
OVchr1739462333Frame_Shift_DelnovelA88Gfs*300.75
OVchr1739519980Missense_MutationNAL996F0.8
OVchr1739471205Missense_MutationnovelP458L0.06
OVchr1739517516Missense_MutationNAK975E0.57
OVchr1739471636Nonsense_MutationNAQ602*0.79
OVchr1739490583Missense_MutationNAP653L0.58
OVchr1739509740Missense_MutationNAR882L0.26
OVchr1739515740Frame_Shift_InsNAE928Gfs*270.54
OVchr1739471592Missense_MutationnovelS587Y0.04
OVchr1739462241Frame_Shift_DelnovelE59Kfs*330.88
OVchr1739520028In_Frame_DelNAT1014_Q1016del0.77
OVchr1739492798Nonsense_MutationNAW719*0.49
OVchr1739519955Splice_SitenovelX988_splice0.81
OVchr1739463099Splice_SiteNAX343_splice0.9
OVchr1739526029Nonsense_MutationnovelS1158delinsRILAVY*NH0.04
OVchr1739494626Frame_Shift_InsNAS785Kfs*40.92
OVchr1739462434Frame_Shift_DelNAL122Tfs*40.94
PAADchr1739462703Missense_Mutationrs778493744K211T0.23
PAADchr1739471409Missense_MutationnovelP526H0.22
PRADchr1739462720Nonsense_MutationNAK217*0.1
PRADchr1739511588Missense_Mutationrs538308945G909E0.12
PRADchr1739520037Silentrs757636720L1015L0.77
PRADchr1739471601Frame_Shift_InsnovelT592Dfs*490.35
PRADchr1739490711Nonsense_MutationnovelQ696*0.38
PRADchr1739494595Missense_MutationnovelE774K0.38
PRADchr1739520000Frame_Shift_DelnovelL1003Rfs*30.41
PRADchr1739531180Missense_MutationNAG1446E0.31
PRADchr1739494660Missense_MutationNAD795E0.63
PRADchr1739531219Frame_Shift_DelNAG1461Afs*380.38
PRADchr1739463095Frame_Shift_InsnovelS343Efs*80.19
PRADchr1739501402Missense_MutationNAR858W0.51
PRADchr1739463118Splice_SiteNAX349_splice0.32
PRADchr1739471594Frame_Shift_DelnovelT588Ifs*480.45
PRADchr1739470879Frame_Shift_DelnovelR350Qfs*30.11
PRADchr1739462233Frame_Shift_DelnovelL55Qfs*320.15
PRADchr1739471624Nonsense_MutationNAQ598*0.3
PRADchr1739524774Missense_Mutationrs747832521S1066P0.34
READchr1739524724Missense_Mutationrs751631029R1049H0.26
READchr1739494610Missense_MutationNAR779C0.44
READchr1739509709Nonsense_MutationNAQ872*0.17
READchr17395314053'UTRnovel0.38
READchr1739470953Missense_MutationNAR374K0.34
READchr1739471256Missense_MutationNAS475Y0.31
READchr1739501341Missense_MutationNAK837N0.26
READchr1739511531Missense_MutationNAR890H0.26
SARCchr1739471376Missense_Mutationrs750167967P515L0.37
SARCchr1739471748Missense_MutationnovelD639V0.19
SARCchr1739471137SilentnovelV435V0.18
SKCMchr1739509739Missense_MutationNAR882W0.36
SKCMchr1739530760Missense_MutationNAS1306F0.22
SKCMchr1739471011SilentnovelS393S0.36
SKCMchr1739517474Missense_MutationNAP961S0.32
SKCMchr1739515792Nonsense_MutationNAQ944*0.53
SKCMchr1739520006Missense_MutationnovelP1005L0.29
SKCMchr1739530761SilentNAS1306S0.07
SKCMchr1739471586Missense_MutationNAP585L0.31
SKCMchr1739494592Missense_MutationNAR773C0.4
SKCMchr1739530709Frame_Shift_DelNAQ1291Rfs*30.13
SKCMchr1739531036Missense_MutationnovelP1398L0.37
SKCMchr1739471535Missense_MutationNAP568L0.36
SKCMchr1739494652Missense_MutationNAV793F0.25
SKCMchr1739524757Missense_MutationNAP1060L0.09
SKCMchr17395313193'UTRnovel0.94
SKCMchr1739524778Missense_Mutationrs143648695R1067Q0.38
SKCMchr1739471466Missense_MutationnovelP545L0.27
SKCMchr1739462296In_Frame_InsnovelD75_I76insLF0.11
SKCMchr1739462297Frame_Shift_InsnovelS77Lfs*190.08
SKCMchr1739494606SilentNAI777I0.55
SKCMchr1739471212SilentnovelT460T0.22
SKCMchr1739517553Missense_Mutationrs201661022S987F0.5
SKCMchr1739462346Missense_MutationNAD92A0.14
SKCMchr1739462348Nonsense_MutationNAR93*0.14
SKCMchr1739471588Missense_MutationNAP586S0.09
SKCMchr17395313503'UTRnovel0.26
SKCMchr1739530780Missense_MutationNAP1313S0.31
SKCMchr17394620345'Flanknovel0.41
SKCMchr1739525868SilentNAL1104L0.98
SKCMchr1739471717Missense_Mutationrs146621695P629S0.46
STADchr1739517535Missense_MutationNAR981H0.15
STADchr1739531179Nonsense_MutationNAG1446*0.05
STADchr1739515738Missense_MutationNAL926I0.05
STADchr17394620515'UTRnovel0.24
STADchr1739492859SilentNAG739G0.29
STADchr1739530707Silentrs780009851S1288S0.19
STADchr1739471188SilentNAK452K0.04
STADchr1739511630Missense_MutationNAG923V0.3
STADchr1739530648Frame_Shift_DelNAG1271Dfs*230.29
STADchr1739494610Missense_MutationNAR779C0.18
STADchr1739530648Frame_Shift_DelNAG1271Dfs*230.22
STADchr1739494611Missense_MutationNAR779H0.18
STADchr1739490669Frame_Shift_DelNAP683Qfs*700.28
STADchr1739509740Missense_MutationNAR882Q0.22
STADchr1739511605Missense_MutationNAP915S0.48
STADchr1739494585SilentNAT770T0.25
STADchr1739530909Nonsense_MutationnovelR1356*0.03
STADchr1739470958Missense_MutationNAS376G0.32
STADchr1739471639Frame_Shift_DelnovelP604Lfs*60.2
STADchr1739524850Missense_MutationnovelP1091L0.29
STADchr1739462898Frame_Shift_InsnovelP277Sfs*210.16
STADchr1739525906Missense_MutationNAA1117E0.08
STADchr1739462432Missense_MutationNAD121H0.4
STADchr1739470964Missense_Mutationrs370304179R378C0.19
STADchr1739490669Frame_Shift_DelNAP683Qfs*700.36
STADchr1739525906Missense_MutationNAA1117V0.27
THCAchr1739526040Missense_MutationNAE1162K0.21
THCAchr1739517551Frame_Shift_InsnovelS987Rfs*180.1
THCAchr17394620705'UTRnovel0.32
UCECchr1739524777Nonsense_MutationNAR1067*0.4
UCECchr1739462694Missense_MutationNAK208T0.24
UCECchr1739471108Missense_MutationnovelF426V0.22
UCECchr1739471256Missense_MutationNAS475Y0.26
UCECchr17395318823'UTRnovel0.42
UCECchr1739517551Missense_MutationNAF986L0.44
UCECchr1739463036Missense_MutationnovelR322L0.32
UCECchr1739471054Missense_MutationnovelA408P0.45
UCECchr1739515786SilentnovelL942L0.32
UCECchr1739530707Silentrs780009851S1288S0.45
UCECchr1739471215SilentnovelE461E0.04
UCECchr1739490583Missense_MutationNAP653H0.21
UCECchr1739490655Missense_MutationNAG677D0.45
UCECchr1739471435Missense_Mutationrs771063488P535S0.52
UCECchr1739470989Missense_MutationnovelP386L0.2
UCECchr1739524683SilentnovelH1035H0.32
UCECchr1739471315SilentnovelL495L0.37
UCECchr1739501343Missense_Mutationrs748453656S838L0.35
UCECchr1739530761SilentnovelS1306S0.46
UCECchr17395319343'UTRnovel0.33
UCECchr17394620425'UTRnovel0.38
UCECchr1739471252Missense_MutationnovelN474H0.27
UCECchr1739471477In_Frame_DelNAL554_P556del0.31
UCECchr1739492793Silentrs777401578S717S0.57
UCECchr1739501402SilentnovelR858R0.41
UCECchr1739471212Frame_Shift_DelnovelL462Cfs*210.38
UCECchr1739462863Missense_MutationnovelK264N0.33
UCECchr1739520014Missense_MutationNAR1008W0.36
UCECchr1739462244Frame_Shift_DelnovelP58Qfs*330.12
UCECchr1739494587Missense_MutationnovelA771V0.43
UCECchr17395319343'UTRnovel0.24
UCECchr1739471247Frame_Shift_InsnovelN474Kfs*120.38
UCECchr1739471503Missense_MutationnovelI557M0.38
UCECchr1739531290Missense_MutationNAG1483R1
UCECchr1739520061Silentrs758539836V1023V0.38
UCECchr1739530836SilentnovelR1331R0.36
UCECchr1739531238Silentrs770310273S1465S0.26
UCECchr1739501402Missense_MutationNAR858W0.48
UCECchr1739462708Missense_MutationNAV213M0.05
UCECchr1739462452SilentnovelQ127Q0.38
UCECchr1739471489Missense_MutationnovelP553T0.09
UCECchr1739490645Nonsense_MutationnovelE674*0.32
UCECchr1739530709Frame_Shift_DelNAQ1291Rfs*30.34
UCECchr1739520014Missense_MutationNAR1008W0.04
UCECchr1739511630Missense_MutationNAG923V0.16
UCECchr1739470891Missense_MutationnovelM353I0.96
UCECchr1739471639Frame_Shift_DelnovelP604Lfs*60.33
UCECchr1739494653Missense_MutationnovelV793A0.71
UCECchr1739511605Missense_MutationNAP915S0.45
UCECchr1739462146SilentnovelS25S0.43
UCECchr1739471584Frame_Shift_InsnovelS587Ffs*540.38
UCECchr1739517457Missense_MutationnovelP955H0.36
UCECchr1739524764Silentrs778467311P1062P0.11
UCECchr17395316823'UTRnovel0.5
UCECchr1739501389Missense_MutationNAK853N0.33
UCECchr1739492807Missense_MutationnovelR722H0.15
UCECchr1739509707Missense_MutationnovelG871E0.19
UCECchr1739511625Missense_MutationnovelS921R0.2
UCECchr1739515744Missense_Mutationrs267604832E928K0.15
UCECchr1739525866Missense_MutationnovelL1104I0.22
UCECchr1739526306Missense_MutationnovelE1250D0.23
UCECchr1739524755Missense_MutationnovelE1059D0.48
UCECchr1739490672Missense_MutationNAP683T0.29
UCECchr1739462234SilentNAL55L0.18
UCECchr1739492807Missense_MutationnovelR722H0.21
UCECchr1739524876Missense_MutationNAD1100N0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.28890.0017784
DLBCDEL00.18166
THCADEL0.0020.221
UCSDEL0.30360.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
KIRC0.011

Kaplan-Meier Survival Analysis

MESO0.011

Kaplan-Meier Survival Analysis

KIRP0.00054

Kaplan-Meier Survival Analysis

PAAD0.0095

Kaplan-Meier Survival Analysis

READ0.002

Kaplan-Meier Survival Analysis

LAML0.0031

Kaplan-Meier Survival Analysis

KICH0.0071

Kaplan-Meier Survival Analysis

LIHC0.012

Kaplan-Meier Survival Analysis

LGG0.038

Kaplan-Meier Survival Analysis

THCA0.036

Kaplan-Meier Survival Analysis

UVM0.047

Kaplan-Meier Survival Analysis

OV0.029

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000167258 (Gene tree)
Gene ID
51755
Gene Symbol
CDK12
Alias
CRK7|CRKR|KIAA0904|CRKRS
Full Name
cyclin dependent kinase 12
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
106,074 bases
Position
chr17:39,461,486-39,567,559
Accession
24224
RBP type
non-canonical RBP
Summary
N
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
25429106Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.J Biol Chem2015 Jan 16Bartkowiak Bdoi: 10.1074/jbc.M114.612226
30819820CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.Genes Dev2019 Apr 1Choi SHdoi: 10.1101/gad.322339.118
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000430627CDK12-2015918-ENSP000004077201481 (aa)-Q9NYV4
ENST00000581963CDK12-207436--- (aa)--
ENST00000584336CDK12-2081963--- (aa)--
ENST00000581593CDK12-206559--- (aa)--
ENST00000559545CDK12-204586--- (aa)--
ENST00000559663CDK12-205871-ENSP00000453329159 (aa)-H0YLT2
ENST00000447079CDK12-2028336XM_005257456ENSP000003988801490 (aa)XP_005257513Q9NYV4
ENST00000558240CDK12-203555--- (aa)--
ENST00000585161CDK12-2102036--- (aa)--
ENST00000584632CDK12-2094165XM_005257458ENSP000004646411201 (aa)XP_005257515J3QSD7
Gene Model
Click here to download ENSG00000167258's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000167258Arthritis, Rheumatoid2E-824390342
ENSG00000167258Glomerular Filtration Rate9E-627588450
ENSG00000167258Forced Expiratory Volume1E-728166213
ENSG00000167258Polycystic Ovary Syndrome1E-626416764
ENSG00000167258Urine4E-2626352407
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000167258rs110789031739475671AGlomerular filtration rate27588450[0.32-0.81] unit decrease0.564EFO_0005208
ENSG00000167258rs72190141739468537AUrinary metabolites26352407[NR] unit decrease0.156EFO_0005116
ENSG00000167258rs124515861739477582AGlomerular filtration rate (creatinine)28452372[0.007-0.0114] unit decrease0.0092EFO_0005208|EFO_0004518
ENSG00000167258rs116507761739485149ALung function (FEV1)28166213[0.017-0.037] unit increase0.027EFO_0004314
ENSG00000167258rs124498521739475835?Red cell distribution width30595370EFO_0005192
ENSG00000167258rs47953841739560518GEstimated glomerular filtration rate30604766[0.2-0.59] ml/min/1.73m2 decrease0.395EFO_0005208
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167258's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000167258CDK1210090.201ENSMUSG00000003119Cdk1210090.268Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000307cyclin-dependent protein kinase holoenzyme complex21873635.IBAComponent
GO:0000790nuclear chromatin21873635.IBAComponent
GO:0001650fibrillar center-IDAComponent
GO:0002944cyclin K-CDK12 complex22012619.IPIComponent
GO:0004672protein kinase activity11683387.IDAFunction
GO:0004693cyclin-dependent protein serine/threonine kinase activity21873635.IBAFunction
GO:0005515protein binding12841360.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005694chromosome21873635.IBAComponent
GO:0006368transcription elongation from RNA polymerase II promoter21873635.IBAProcess
GO:0006397mRNA processing-IEAProcess
GO:0006468protein phosphorylation21873635.IBAProcess
GO:0008024cyclin/CDK positive transcription elongation factor complex21873635.IBAComponent
GO:0008134transcription factor binding21873635.IBAFunction
GO:0008353RNA polymerase II CTD heptapeptide repeat kinase activity21873635.IBAFunction
GO:0008353RNA polymerase II CTD heptapeptide repeat kinase activity20952539.IMPFunction
GO:0008380RNA splicing-ISSProcess
GO:0016607nuclear speck11683387.IDAComponent
GO:0019901protein kinase binding-IEAFunction
GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex-ISSComponent
GO:0030332cyclin binding21873635.IBAFunction
GO:0030332cyclin binding22012619.IPIFunction
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter21873635.IBAProcess
GO:0043405regulation of MAP kinase activity19651820.IMPProcess
GO:0043484regulation of RNA splicing-IEAProcess
GO:0044212transcription regulatory region DNA binding21873635.IBAFunction
GO:0045944positive regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0046777protein autophosphorylation11683387.IDAProcess
GO:0051726regulation of cell cycle-IEAProcess
GO:0070816phosphorylation of RNA polymerase II C-terminal domain21873635.IBAProcess
GO:0070816phosphorylation of RNA polymerase II C-terminal domain20952539.IMPProcess
GO:2000737negative regulation of stem cell differentiation-IEAProcess
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