EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
12582162The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.J Biol Chem2003 Apr 18Li Y-
25228695Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach.J Biol Chem2014 Nov 7Jasinski-Bergner Sdoi: 10.1074/jbc.M114.556290
21598387Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker.Proteomics2011 JunTseng CWdoi: 10.1002/pmic.201000449

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2044901588Missense_MutationNAE19K0.47
BLCAchr2044906421Missense_MutationNAG242R0.29
BRCAchr2044901717Missense_MutationNAR62C0.24
BRCAchr2044905048Missense_MutationNAR169C0.24
BRCAchr2044904978SilentnovelS145S0.34
CESCchr2044901786Missense_MutationnovelR85C0.31
COADchr2044901654Missense_MutationNAE41K0.35
COADchr20449064553'UTRnovel0.16
COADchr2044901702Missense_MutationNAR57C0.36
COADchr20449065163'UTRnovel0.39
ESCAchr2044905027Missense_MutationnovelM162V0.4
GBMchr2044901630Nonsense_MutationnovelE33*0.36
HNSCchr2044905087Missense_MutationnovelE182Q0.05
HNSCchr2044901536Translation_Start_SitenovelM1?0.18
HNSCchr2044901698Silentrs745735230G55G0.31
KIRCchr2044905131Splice_RegionNAT196T0.14
KIRPchr2044901575Silentrs148717452L14L0.62
LAMLchr20449064643'UTRnovel0.06
LGGchr2044906038Missense_MutationnovelN209S0.33
LGGchr2044904062Missense_MutationnovelK124E0.35
LGGchr2044901762Missense_Mutationrs142757633K77Q0.27
LUADchr2044901706Missense_MutationNAR58L0.18
LUADchr2044901620SilentNAK29K0.23
LUSCchr2044901673Missense_MutationNAS47F0.4
OVchr2044904004Missense_MutationNAD104E0.38
OVchr2044906082Missense_MutationnovelR224W0.06
PAADchr2044901818SilentnovelI95I0.17
PRADchr2044901591Nonsense_MutationnovelR20*0.45
SARCchr2044904007SilentNAK105K0.45
SKCMchr2044901679Missense_MutationNAA49V0.12
SKCMchr2044901701SilentnovelA56A0.38
SKCMchr2044904049SilentNAF119F0.16
STADchr2044901671SilentNAL46L0.09
STADchr2044906417Silentrs150381005D240D0.44
STADchr2044901592Missense_MutationNAR20Q0.23
STADchr2044901654Missense_MutationNAE41K0.15
THYMchr20449067043'UTRnovel0.08
UCECchr20449066863'UTRnovel0.07
UCECchr20449080423'UTRnovel0.47
UCECchr20449081753'UTRnovel0.53
UCECchr2044905048Missense_MutationNAR169C0.07
UCECchr20449065063'UTRnovel0.58
UCECchr20449081573'UTRnovel0.39
UCECchr20449082683'UTRnovel0.31
UCECchr20449081573'UTRnovel0.35
UCECchr2044901641SilentNAH36H0.38
UCECchr2044901706Missense_Mutationrs11556823R58H0.46
UCECchr2044905131Splice_RegionNAT196T0.37
UCECchr20449083253'UTRrs5454706270.33
UCECchr2044906007Missense_MutationnovelD199N0.29
UCECchr2044906032Missense_Mutationrs374058745T207M0.51
UCECchr20449085093'UTRnovel0.56
UCECchr20449068343'UTRnovel0.47
UCECchr2044905048Missense_MutationNAR169C0.32
UCECchr20449081573'UTRnovel0.37
UCECchr20449067823'UTRnovel0.26
UCECchr2044905048Missense_MutationNAR169C0.5
UCECchr20449081753'UTRnovel0.21
UCECchr2044901791SilentnovelE86E0.04
UCECchr2044904978Silentrs760401900S145S0.27
UCECchr20449081753'UTRnovel0.05
UCECchr20449066403'UTRnovel0.33
UCECchr2044905003Missense_MutationnovelA154S0.16
UCECchr20449065423'UTRnovel0.55
UCECchr20449069533'UTRnovel0.33
UCECchr20449081753'UTRnovel0.54
UCECchr2044904978Silentrs760401900S145S0.39

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.02090.14746
LUADDEL0.12210.18308
PRADAMP0.04880.07085

Survival Analysis
CancerP-value Q-value
THYM0.0016

Kaplan-Meier Survival Analysis

KIRC0.00012

Kaplan-Meier Survival Analysis

HNSC0.0011

Kaplan-Meier Survival Analysis

LUSC0.023

Kaplan-Meier Survival Analysis

BRCA0.0011

Kaplan-Meier Survival Analysis

ESCA0.022

Kaplan-Meier Survival Analysis

PAAD0.0069

Kaplan-Meier Survival Analysis

LAML0.0021

Kaplan-Meier Survival Analysis

KICH0.05

Kaplan-Meier Survival Analysis

UCEC0.00048

Kaplan-Meier Survival Analysis

LIHC0.00013

Kaplan-Meier Survival Analysis

LUAD0.05

Kaplan-Meier Survival Analysis

UVM0.0013

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000166913 (Gene tree)
Gene ID
7529
Gene Symbol
YWHAB
Alias
YWHAA
Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
22,934 bases
Position
chr20:44,885,599-44,908,532
Accession
12849
RBP type
non-canonical RBP
Summary
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000477896YWHAB-205410--- (aa)--
ENST00000633979YWHAB-208689XM_017028040ENSP0000048817881 (aa)XP_016883529A0A0J9YWZ2
ENST00000428262YWHAB-203648-ENSP00000394729100 (aa)-Q4VY19
ENST00000479421YWHAB-2061097-ENSP00000487924149 (aa)-A0A0J9YWE8
ENST00000372839YWHAB-2023109XM_017028039ENSP00000361930246 (aa)XP_016883528P31946
ENST00000445830YWHAB-204556-ENSP0000039455874 (aa)-Q4VY20
ENST00000353703YWHAB-2013049-ENSP00000300161246 (aa)-P31946
ENST00000631616YWHAB-2075867--- (aa)--
Gene Model
Click here to download ENSG00000166913's gene model file
Pathways
Pathway IDPathway NameSource
hsa04110Cell cycleKEGG
hsa04114Oocyte meiosisKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04390Hippo signaling pathwayKEGG
hsa05160Hepatitis CKEGG
hsa05161Hepatitis BKEGG
hsa05203Viral carcinogenesisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000166913Platelet Function Tests1.6716000E-005-
ENSG00000166913Platelet Function Tests7.7900000E-006-
ENSG00000166913Platelet Function Tests4.4200000E-006-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000166913rs22842652044888400CBlood protein levels30072576[0.13-0.23] unit increase0.176EFO_0007937
ENSG00000166913rs24256702044893088?Menarche (age at onset)30595370EFO_0004703
ENSG00000166913rs83562044907814?Body mass index30595370EFO_0004340
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166913's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000166913YWHAB9786.111WBGene00001502ftt-29978.776Caenorhabditis_elegans
ENSG00000166913YWHAB9690.141FBgn000490714-3-3zeta9879.424Drosophila_melanogaster
ENSG00000166913YWHAB9592.857ENSG00000164924YWHAZ10092.157Homo_sapiens
ENSG00000166913YWHAB9587.143ENSG00000134308YWHAQ9981.818Homo_sapiens
ENSG00000166913YWHAB100100.000ENSMUSG00000018326Ywhab10098.780Mus_musculus
ENSG00000166913YWHAB9592.857ENSMUSG00000022285Ywhaz10092.308Mus_musculus
ENSG00000166913YWHAB9587.143ENSMUSG00000076432Ywhaq9981.818Mus_musculus
ENSG00000166913YWHAB9372.464ENSMUSG00000047281Sfn9668.201Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000165MAPK cascade-TASProcess
GO:0005515protein binding7644510.7882972.7935795.8085158.9341175.10713667.10958686.11157475.11697890.11886850.12582162.12620389.12963375.14688255.14701738.14743216.15023544.15159416.15860732.15883195.16672054.16672277.16775625.16868027.16959763.17085597.17170118.17229891.17923693.17974916.18308725.18460465.18771726.19172738.19329994.19439659.19470455.19592491.19595761.19640509.19860830.20025850.20048001.20169078.20642453.20936779.21224381.21262972.21278420.21771788.21972092.22078878.22190034.23572552.23602568.23622247.23752268.24255178.24366813.24510904.24947832.25588844.25852190.26496610.28330616.IPIFunction
GO:0005634nucleus-IEAComponent
GO:0005737cytoplasm10869435.12963375.IDAComponent
GO:0005739mitochondrion-IEAComponent
GO:0005774vacuolar membrane-IEAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006605protein targeting-IEAProcess
GO:0008022protein C-terminus binding-IEAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016032viral process-IEAProcess
GO:0017053transcriptional repressor complex-IEAComponent
GO:0019899enzyme binding17255105.IPIFunction
GO:0019904protein domain specific binding11984006.IPIFunction
GO:0035308negative regulation of protein dephosphorylation17255105.IDAProcess
GO:0035329hippo signaling-TASProcess
GO:0042470melanosome-IEAComponent
GO:0042802identical protein binding17085597.23622247.IPIFunction
GO:0042826histone deacetylase binding10869435.IPIFunction
GO:0043085positive regulation of catalytic activity17255105.IDAProcess
GO:0043488regulation of mRNA stability-TASProcess
GO:0044877protein-containing complex binding-IEAFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0045744negative regulation of G protein-coupled receptor signaling pathway21224381.IMPProcess
GO:0045892negative regulation of transcription, DNA-templated-IEAProcess
GO:0048471perinuclear region of cytoplasm12963375.IDAComponent
GO:0050815phosphoserine residue binding10869435.IPIFunction
GO:0051219phosphoprotein binding10869435.IPIFunction
GO:0051220cytoplasmic sequestering of protein10869435.IDAProcess
GO:0051291protein heterooligomerization-IEAProcess
GO:0061024membrane organization-TASProcess
GO:0070062extracellular exosome19199708.20458337.HDAComponent
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TASProcess
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