EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21992474	GP96 is over-expressed in oral cavity cancer and is a poor prognostic indicator for patients receiving radiotherapy.	Radiat Oncol	2011 Oct 12	Lin CY	doi: 10.1186/1748-717X-6-136.
25880332	MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL.	BMC Cancer	2015 Apr 8	Rodr??guez-Vicente AE	doi: 10.1186/s12885-015-1212-2.
18331622	Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus.	BMC Cancer	2008 Mar 10	Langer R	doi: 10.1186/1471-2407-8-70.
23208072	Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma.	Cell Physiol Biochem	2012	Li G	doi: 10.1159/000343336
27662661	Grp94 in complexes with IgG is a soluble diagnostic marker of gastrointestinal tumors and displays immune-stimulating activity on peripheral blood immune cells.	Oncotarget	2016 Nov 8	Tramentozzi E	doi: 10.18632/oncotarget.12141.
22245095	Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.	Free Radic Biol Med	2012 Mar 15	Dejeans N	doi: 10.1016/j.freeradbiomed.2011.12.019
27599983	HSP90B1 overexpression predicts poor prognosis in NSCLC patients.	Tumour Biol	2016 Oct	Xu Y	-
25973087	Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance.	Int J Clin Exp Pathol	2015 Feb 1	Chen Y	-
19724918	Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells.	Int J Oncol	2009 Oct	Pan Z	-
26497551	FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies.	Oncotarget	2015 Dec 29	Mart??nez-Aranda A	doi: 10.18632/oncotarget.5471.
18340425	Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer.	Clin Exp Metastasis	2008	Howard EW	doi: 10.1007/s10585-008-9157-3
17545519	Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins.	Clin Cancer Res	2007 Jun 1	Esseghir S	-
19212831	Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1.	Cancer Invest	2009 May	Zhang L	doi: 10.1080/07357900802527239.
25637791	Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.	Cancer Lett	2015 Apr 10	Wu B	doi: 10.1016/j.canlet.2015.01.034
20704820	[Expression and significance of gp96 and immune-related gene CTLA-4, CD8 in lung cancer tissues].	Zhongguo Fei Ai Za Zhi	2010 Aug	Zheng H	doi: 10.3779/j.issn.1009-3419.2010.08.08.
28347227	Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.	Tumour Biol	2017 Mar	Cai Q	doi: 10.1177/1010428317695015.
28706421	Gastric cancer-derived heat shock protein-gp96 peptide complex enhances dendritic cell activation.	World J Gastroenterol	2017 Jun 28	Lu WW	doi: 10.3748/wjg.v23.i24.4390.
29368272	Concomitant high expression of ERα36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior.	Cell Oncol (Dordr)	2018 Jun	Dai YJ	doi: 10.1007/s13402-017-0368-y
29852388	Glucose-regulated protein of 94 kDa contributes to the development of an aggressive phenotype in breast cancer cells.	Biomed Pharmacother	2018 Sep	Buc Calderon P	doi: 10.1016/j.biopha.2018.05.106

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	103932834	Silent	novel	L101L	0.3
BLCA	chr12	103942789	Missense_Mutation	NA	R546T	0.07
BLCA	chr12	103934084	Silent	novel	E180E	0.1
BLCA	chr12	103938403	Missense_Mutation	novel	D307Y	0.36
BLCA	chr12	103942730	Silent	rs372371380	Q526Q	0.22
BLCA	chr12	103947413	Missense_Mutation	NA	E789K	0.58
BLCA	chr12	103939608	Missense_Mutation	novel	Y359H	0.1
BLCA	chr12	103947651	Missense_Mutation	rs777767051	D801H	0.33
BLCA	chr12	103934039	Silent	NA	T165T	0.38
BLCA	chr12	103946798	Missense_Mutation	novel	D707H	0.13
BLCA	chr12	103934050	Missense_Mutation	novel	S169F	0.21
BLCA	chr12	103946888	Missense_Mutation	novel	D737N	0.31
BLCA	chr12	103943746	Silent	novel	K633K	0.07
BLCA	chr12	103933970	Missense_Mutation	novel	K142N	0.18
BLCA	chr12	103941626	Splice_Region	novel		0.23
BLCA	chr12	103932898	Missense_Mutation	NA	E123K	0.45
BRCA	chr12	103942628	Silent	novel	I492I	0.14
BRCA	chr12	103932399	Missense_Mutation	NA	S92L	0.18
BRCA	chr12	103943737	Splice_Site	NA	X631_splice	0.27
BRCA	chr12	103938421	Missense_Mutation	rs200904772	E313Q	0.08
CESC	chr12	103930458	5'UTR	novel		0.5
CESC	chr12	103930518	Translation_Start_Site	NA	M1?	0.3
CESC	chr12	103938394	Missense_Mutation	novel	E304K	0.41
CESC	chr12	103943848	Silent	novel	Y667Y	0.42
CESC	chr12	103941527	Frame_Shift_Del	novel	*K405Rfs21**	0.09
COAD	chr12	103934143	Missense_Mutation	NA	Y200F	0.29
COAD	chr12	103939567	Missense_Mutation	NA	R345I	0.41
COAD	chr12	103934148	Missense_Mutation	rs368251601	A202T	0.24
COAD	chr12	103947407	In_Frame_Del	NA	D787del	0.27
COAD	chr12	103943761	Silent	NA	Q638Q	0.46
COAD	chr12	103934081	Silent	NA	T179T	0.3
COAD	chr12	103947646	Frame_Shift_Del	novel	*D801Mfs56**	0.21
COAD	chr12	103946626	Missense_Mutation	rs373656293	A679V	0.36
COAD	chr12	103942655	Silent	rs768070489	S501S	0.24
COAD	chr12	103947411	Missense_Mutation	novel	E788G	0.1
COAD	chr12	103932838	Nonsense_Mutation	NA	E103*	0.32
COAD	chr12	103932921	Silent	novel	E130E	0.29
COAD	chr12	103934021	In_Frame_Ins	novel	L159_V160insYLI	0.05
COAD	chr12	103934022	Missense_Mutation	novel	V160F	0.03
COAD	chr12	103942654	Missense_Mutation	novel	S501L	0.1
COAD	chr12	103942556	Silent	rs200554688	T468T	0.44
COAD	chr12	103943252	Missense_Mutation	rs756076475	R608H	0.05
COAD	chr12	103941638	Missense_Mutation	rs368374645	R414C	0.33
ESCA	chr12	103943757	Missense_Mutation	novel	S637C	0.1
ESCA	chr12	103947646	Frame_Shift_Del	novel	*D801Mfs56**	0.55
ESCA	chr12	103941490	Silent	novel	T391T	0.22
GBM	chr12	103934071	Missense_Mutation	novel	N176S	0.06
GBM	chr12	103943098	Nonsense_Mutation	novel	R557*	0.41
GBM	chr12	103932846	Missense_Mutation	novel	I105M	0.08
GBM	chr12	103947832	3'UTR	novel		0.25
HNSC	chr12	103947666	3'UTR	novel		0.31
HNSC	chr12	103941869	Missense_Mutation	novel	E449V	0.22
HNSC	chr12	103943204	Missense_Mutation	rs762366467	A592G	0.14
HNSC	chr12	103943260	Missense_Mutation	novel	V611F	0.31
HNSC	chr12	103943295	Missense_Mutation	novel	M622I	0.16
HNSC	chr12	103946665	Missense_Mutation	rs372636341	P692L	0.18
HNSC	chr12	103942796	Splice_Region	novel	E548E	0.18
KIRC	chr12	103947417	Missense_Mutation	NA	E790A	0.25
KIRC	chr12	103941867	Silent	rs752170920	R448R	0.05
KIRC	chr12	103938448	Missense_Mutation	novel	K322E	0.27
KIRC	chr12	103947632	Splice_Site	NA	X795_splice	0.22
KIRP	chr12	103942669	Missense_Mutation	NA	L506P	0.59
LGG	chr12	103941494	Missense_Mutation	novel	A393T	0.1
LGG	chr12	103943803	Silent	rs781455876	Y652Y	0.48
LIHC	chr12	103934184	Missense_Mutation	novel	K214E	0.1
LIHC	chr12	103943778	Missense_Mutation	novel	P644Q	0.21
LUAD	chr12	103932333	Missense_Mutation	novel	R70T	0.11
LUAD	chr12	103930518	Translation_Start_Site	NA	M1?	0.1
LUAD	chr12	103932907	Missense_Mutation	novel	L126I	0.13
LUAD	chr12	103943174	Missense_Mutation	NA	E582G	0.1
LUAD	chr12	103942642	Missense_Mutation	novel	I497N	0.41
LUAD	chr12	103931616	In_Frame_Ins	novel	V49delinsGKGRGCKIQL	0.17
LUAD	chr12	103946831	Missense_Mutation	novel	F718L	0.1
LUAD	chr12	103937713	Missense_Mutation	NA	E254D	0.27
LUAD	chr12	103943079	Missense_Mutation	NA	E550D	0.27
LUAD	chr12	103946937	Missense_Mutation	NA	A753G	0.2
LUSC	chr12	103943224	Missense_Mutation	novel	D599N	0.15
LUSC	chr12	103947389	Missense_Mutation	NA	E781Q	0.3
LUSC	chr12	103946904	In_Frame_Del	novel	L743_L747del	0.05
LUSC	chr12	103943238	Frame_Shift_Ins	novel	*T604Efs6**	0.05
LUSC	chr12	103943240	Frame_Shift_Del	novel	*T604Ifs16**	0.1
LUSC	chr12	103934094	Missense_Mutation	NA	D184H	0.06
LUSC	chr12	103943816	Missense_Mutation	rs3209749	N657H	0.1
LUSC	chr12	103937773	Missense_Mutation	NA	F274L	0.12
LUSC	chr12	103943230	Missense_Mutation	novel	S601G	0.4
OV	chr12	103942674	Nonsense_Mutation	novel	*K508delinsICMDSISAQSE**	0.06
OV	chr12	103946648	Frame_Shift_Ins	novel	*I687Vfs9**	0.07
OV	chr12	103946650	In_Frame_Ins	novel	I687_N688insS	0.04
OV	chr12	103941669	Missense_Mutation	NA	D424V	0.44
PAAD	chr12	103932827	Frame_Shift_Del	novel	*F100Sfs2**	0.24
PAAD	chr12	103946820	Missense_Mutation	novel	A714D	0.2
PAAD	chr12	103934210	Silent	novel	I222I	0.04
PRAD	chr12	103934156	Frame_Shift_Del	novel	*V205Hfs15**	0.07
PRAD	chr12	103942665	Missense_Mutation	novel	R505C	0.13
READ	chr12	103947380	Missense_Mutation	rs760087578	E778K	0.22
READ	chr12	103942717	Missense_Mutation	novel	T522I	0.05
READ	chr12	103932838	Nonsense_Mutation	NA	E103*	0.06
READ	chr12	103937776	Missense_Mutation	NA	I275M	0.3
READ	chr12	103939533	Missense_Mutation	novel	E334K	0.41
READ	chr12	103942611	Nonsense_Mutation	NA	E487*	0.41
READ	chr12	103947380	Missense_Mutation	rs760087578	E778K	0.33
SKCM	chr12	103934153	Silent	novel	F203F	0.31
SKCM	chr12	103932284	Missense_Mutation	NA	E54K	0.18
SKCM	chr12	103938385	Missense_Mutation	NA	E301K	0.24
SKCM	chr12	103943849	Nonsense_Mutation	NA	Q668*	0.2
SKCM	chr12	103934019	Silent	NA	L159L	0.41
SKCM	chr12	103932319	Silent	NA	Q65Q	0.68
SKCM	chr12	103947701	3'UTR	novel		0.18
STAD	chr12	103941638	Missense_Mutation	rs368374645	R414C	0.17
STAD	chr12	103932838	Nonsense_Mutation	NA	E103*	0.32
STAD	chr12	103943308	Frame_Shift_Ins	novel	*L627Qfs3**	0.06
STAD	chr12	103934289	Splice_Site	novel	X248_splice	0.21
STAD	chr12	103941527	Frame_Shift_Del	novel	*K405Rfs21**	0.19
STAD	chr12	103946849	Missense_Mutation	rs770752783	R724W	0.15
TGCT	chr12	103939541	Missense_Mutation	novel	M336I	0.09
THYM	chr12	103947825	3'UTR	rs751765634		0.19
THYM	chr12	103930458	5'UTR	novel		0.15
UCEC	chr12	103932838	Nonsense_Mutation	NA	E103*	0.31
UCEC	chr12	103934214	Missense_Mutation	NA	E224K	0.38
UCEC	chr12	103942659	Nonsense_Mutation	NA	R503*	0.23
UCEC	chr12	103947779	3'UTR	novel		0.34
UCEC	chr12	103934260	Missense_Mutation	novel	N239S	0.08
UCEC	chr12	103943223	Silent	NA	F598F	0.39
UCEC	chr12	103932308	Missense_Mutation	NA	N62H	0.42
UCEC	chr12	103943223	Silent	NA	F598F	0.43
UCEC	chr12	103947380	Missense_Mutation	rs760087578	E778K	0.34
UCEC	chr12	103943129	Missense_Mutation	novel	Y567C	0.45
UCEC	chr12	103930458	5'UTR	novel		0.5
UCEC	chr12	103938337	Splice_Region	novel		0.28
UCEC	chr12	103943173	Missense_Mutation	rs769155096	E582K	0.44
UCEC	chr12	103938457	Missense_Mutation	NA	K325Q	0.43
UCEC	chr12	103942660	Missense_Mutation	rs753142679	R503Q	0.38
UCEC	chr12	103947922	3'UTR	novel		0.12
UCEC	chr12	103947924	3'UTR	novel		0.12
UCEC	chr12	103941439	Missense_Mutation	novel	H374Q	0.48
UCEC	chr12	103947728	3'UTR	novel		0.46
UCEC	chr12	103943098	Nonsense_Mutation	novel	R557*	0.3
UCEC	chr12	103946666	Silent	rs771669006	P692P	0.35
UCEC	chr12	103947903	3'UTR	novel		0.5
UCEC	chr12	103941492	Missense_Mutation	NA	S392Y	0.21
UCEC	chr12	103942766	Silent	novel	I538I	0.09
UCEC	chr12	103943260	Missense_Mutation	rs567003190	V611I	0.18
UCEC	chr12	103941537	Frame_Shift_Del	NA	Y408*	0.25
UCEC	chr12	103947636	Missense_Mutation	novel	S796A	0.23
UCEC	chr12	103931555	Missense_Mutation	NA	D28E	0.26
UCEC	chr12	103943210	Missense_Mutation	novel	E594G	0.04
UCEC	chr12	103946686	Missense_Mutation	rs769723826	R699Q	0.31
UCEC	chr12	103946794	Missense_Mutation	NA	E705D	0.17
UCEC	chr12	103942655	Silent	rs768070489	S501S	0.28
UCEC	chr12	103947825	3'UTR	rs751765634		0.35
UCEC	chr12	103932858	Silent	novel	S109S	0.45
UCEC	chr12	103942660	Missense_Mutation	rs753142679	R503Q	0.41
UCEC	chr12	103947812	3'UTR	novel		0.4
UCEC	chr12	103942660	Missense_Mutation	rs753142679	R503Q	0.14
UCEC	chr12	103943108	Missense_Mutation	novel	K560T	0.27
UCEC	chr12	103937747	Missense_Mutation	novel	N266H	0.54
UCEC	chr12	103943269	Nonsense_Mutation	novel	E614*	0.26
UCEC	chr12	103947389	Nonsense_Mutation	NA	E781*	0.3
UCEC	chr12	103942611	Nonsense_Mutation	NA	E487*	0.16
UCEC	chr12	103943779	Silent	rs146313005	P644P	0.26
UCEC	chr12	103942600	Missense_Mutation	novel	T483I	0.38
UCEC	chr12	103947412	Missense_Mutation	NA	E788D	0.3
UCEC	chr12	103937756	Frame_Shift_Del	NA	*K270Nfs6**	0.34
UCEC	chr12	103941488	Missense_Mutation	novel	T391A	0.26
UCEC	chr12	103942666	Missense_Mutation	novel	R505H	0.37
UCEC	chr12	103932375	Missense_Mutation	novel	R84I	0.54
UCEC	chr12	103947347	Missense_Mutation	rs370313687	A767T	0.55
UCEC	chr12	103938372	Silent	novel	E296E	0.08
UCEC	chr12	103942720	Missense_Mutation	NA	S523N	0.11
UCEC	chr12	103934047	Missense_Mutation	novel	K168R	0.39
UCEC	chr12	103941535	Silent	rs761631299	S406S	0.11
UCEC	chr12	103947389	Nonsense_Mutation	NA	E781*	0.39
UCEC	chr12	103946804	Frame_Shift_Del	novel	*T709Sfs10**	0.52
UCEC	chr12	103941516	Missense_Mutation	novel	E400G	0.36
UCEC	chr12	103932312	Missense_Mutation	NA	A63V	0.69
UCEC	chr12	103934212	Nonsense_Mutation	novel	W223*	0.13
UCEC	chr12	103947827	3'UTR	novel		0.27
UCEC	chr12	103943173	Missense_Mutation	rs769155096	E582K	0.32
UCEC	chr12	103947697	3'UTR	novel		0.33
UCEC	chr12	103932850	Missense_Mutation	novel	N107H	0.44
UCEC	chr12	103941690	Missense_Mutation	novel	N431S	0.39
UCEC	chr12	103946689	Missense_Mutation	rs773080167	R700Q	0.36
UCS	chr12	103941645	Missense_Mutation	novel	V416A	0.31
UCS	chr12	103942655	Silent	rs768070489	S501S	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0333	0.20414
CHOL	DEL	0.2222	0.067545
HNSC	DEL	0.0613	0.22646
LUAD	DEL	0.1473	0.0059643
LUSC	DEL	0.0958	0.038823
PAAD	DEL	0.1848	0.0030251
PRAD	AMP	0.061	0.016187
READ	DEL	0.097	0.064633
SKCM	DEL	0.1962	0.00079981

Survival Analysis

Cancer	P-value	Q-value
SARC	0.00013	Kaplan-Meier Survival Analysis
MESO	0.0064	Kaplan-Meier Survival Analysis
ACC	0.017	Kaplan-Meier Survival Analysis
HNSC	0.0084	Kaplan-Meier Survival Analysis
SKCM	0.00074	Kaplan-Meier Survival Analysis
ESCA	0.0092	Kaplan-Meier Survival Analysis
KIRP	0.00041	Kaplan-Meier Survival Analysis
PCPG	0.04	Kaplan-Meier Survival Analysis
CESC	0.048	Kaplan-Meier Survival Analysis
LAML	0.005	Kaplan-Meier Survival Analysis
KICH	0.014	Kaplan-Meier Survival Analysis
GBM	0.0086	Kaplan-Meier Survival Analysis
LIHC	0.035	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
CHOL	0.0063	Kaplan-Meier Survival Analysis
UVM	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000166598 (Gene tree)
Gene ID: 7184
Gene Symbol: HSP90B1
Alias: GP96|GRP94|TRA1
Full Name: heat shock protein 90 beta family member 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 23,539 bases
Position: chr12:103,930,107-103,953,645
Accession: 12028
Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25111690	Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.	Lab Invest	2014 Oct	Choi YJ	doi: 10.1038/labinvest.2014.98
21048103	Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation.	J Immunol	2010 Dec 1	Jockheck-Clark AR	doi: 10.4049/jimmunol.1000448

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000548462	HSP90B1-203	3032	-	-	- (aa)	-	-
ENST00000552051	HSP90B1-209	581	-	-	- (aa)	-	-
ENST00000540297	HSP90B1-202	590	-	ENSP00000446266	53 (aa)	-	F8VPC7
ENST00000550479	HSP90B1-206	698	-	-	- (aa)	-	-
ENST00000549334	HSP90B1-205	581	-	ENSP00000446748	48 (aa)	-	F8W026
ENST00000550595	HSP90B1-207	694	-	ENSP00000450215	147 (aa)	-	H0YIV0
ENST00000548622	HSP90B1-204	839	-	-	- (aa)	-	-
ENST00000551983	HSP90B1-208	728	-	-	- (aa)	-	-
ENST00000614327	HSP90B1-210	1338	-	ENSP00000477660	315 (aa)	-	Q96GW1
ENST00000299767	HSP90B1-201	2858	-	ENSP00000299767	803 (aa)	-	P14625
ENST00000640977	HSP90B1-211	1127	-	ENSP00000492386	315 (aa)	-	A0A1W2PRR1

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04657	IL-17 signaling pathway	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa04918	Thyroid hormone synthesis	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05215	Prostate cancer	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000166598	rs1165693	12	103946426	A	Blood protein levels	29875488	[1.06-1.14] unit increase	1.1	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166598's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166598	HSP90B1	100	64.583	WBGene00000915	daf-21	96	48.613	Caenorhabditis_elegans
ENSG00000166598	HSP90B1	100	70.833	FBgn0001233	Hsp83	58	48.571	Drosophila_melanogaster
ENSG00000166598	HSP90B1	77	54.054	FBgn0026761	Trap1	96	30.831	Drosophila_melanogaster
ENSG00000166598	HSP90B1	100	68.750	ENSG00000080824	HSP90AA1	73	71.053	Homo_sapiens
ENSG00000166598	HSP90B1	100	70.833	ENSG00000096384	HSP90AB1	57	48.815	Homo_sapiens
ENSG00000166598	HSP90B1	90	51.163	ENSG00000126602	TRAP1	100	48.571	Homo_sapiens
ENSG00000166598	HSP90B1	100	97.917	ENSMUSG00000020048	Hsp90b1	100	95.890	Mus_musculus
ENSG00000166598	HSP90B1	100	70.833	ENSMUSG00000023944	Hsp90ab1	95	59.722	Mus_musculus
ENSG00000166598	HSP90B1	100	68.750	ENSMUSG00000021270	Hsp90aa1	92	54.974	Mus_musculus
ENSG00000166598	HSP90B1	67	59.375	ENSMUSG00000005981	Trap1	90	31.742	Mus_musculus
ENSG00000166598	HSP90B1	100	66.667	YPL240C	HSP82	96	48.191	Saccharomyces_cerevisiae
ENSG00000166598	HSP90B1	100	64.583	YMR186W	HSC82	96	48.980	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001666	response to hypoxia	21873635.	IBA	Process
GO:0001666	response to hypoxia	15620698.	IDA	Process
GO:0002224	toll-like receptor signaling pathway	-	TAS	Process
GO:0003723	RNA binding	11958450.	IDA	Function
GO:0005509	calcium ion binding	10497210.	TAS	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	9596688.11907036.11958450.15845869.18264092.23349634.23995768.26496610.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	17344063.	IDA	Component
GO:0005783	endoplasmic reticulum	16130169.	TAS	Component
GO:0005788	endoplasmic reticulum lumen	10497210.	IDA	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005789	endoplasmic reticulum membrane	10497210.	IDA	Component
GO:0005829	cytosol	9596688.	IDA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006898	receptor-mediated endocytosis	-	TAS	Process
GO:0015031	protein transport	15845869.	NAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019221	cytokine-mediated signaling pathway	-	TAS	Process
GO:0019903	protein phosphatase binding	19000834.	IDA	Function
GO:0030433	ubiquitin-dependent ERAD pathway	18264092.	IMP	Process
GO:0030496	midbody	15166316.	IDA	Component
GO:0030970	retrograde protein transport, ER to cytosol	25660456.	IMP	Process
GO:0031247	actin rod assembly	19000834.	IDA	Process
GO:0032991	protein-containing complex	23349634.	IDA	Component
GO:0034663	endoplasmic reticulum chaperone complex	-	IEA	Component
GO:0034975	protein folding in endoplasmic reticulum	22013210.	TAS	Process
GO:0034976	response to endoplasmic reticulum stress	22934019.	TAS	Process
GO:0036500	ATF6-mediated unfolded protein response	-	TAS	Process
GO:0042470	melanosome	-	IEA	Component
GO:0043066	negative regulation of apoptotic process	10497210.15192333.	IMP	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043666	regulation of phosphoprotein phosphatase activity	19000834.	IDA	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0048471	perinuclear region of cytoplasm	21873635.	IBA	Component
GO:0048471	perinuclear region of cytoplasm	10497210.	IDA	Component
GO:0050750	low-density lipoprotein particle receptor binding	15082773.	IDA	Function
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0051208	sequestering of calcium ion	15192333.	NAS	Process
GO:0062023	collagen-containing extracellular matrix	23658023.	HDA	Component
GO:0070062	extracellular exosome	19199708.20458337.	HDA	Component
GO:0071318	cellular response to ATP	19000834.	IDA	Process
GO:0071682	endocytic vesicle lumen	-	TAS	Component

EuRBPDB

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Description

RBPome

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Expression

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Pathway

GWAS

PPI

Ortholog

Gene Ontology

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