EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17968325Cellular senescence bypass screen identifies new putative tumor suppressor genes.Oncogene2008 Mar 27Leal JF-
17929852The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.J Proteome Res2007 NovFegers I-
26942699DDA1 promotes stage IIB-IIC colon cancer progression by activating NF??B/CSN2/GSK-3β signaling.Oncotarget2016 Apr 12Zhao Sdoi: 10.18632/oncotarget.7847.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1549130809Nonsense_MutationNAQ319*0.17
BLCAchr1549144997Missense_MutationNAD46N0.42
BLCAchr1549139575Missense_MutationNAE109Q0.49
BLCAchr1549139602Missense_Mutationrs745372669R100W0.2
BLCAchr1549145071Missense_MutationNAS21C0.26
BLCAchr1549128748Missense_MutationnovelD381H0.29
BLCAchr1549130781Frame_Shift_DelnovelK328Dfs*120.36
BLCAchr1549133946Missense_MutationNAP293Q0.49
BLCAchr1549139554Missense_MutationNAL116I0.43
BLCAchr1549134086Missense_MutationnovelL246F0.07
BRCAchr15491279163'UTRnovel0.06
BRCAchr1549128741Missense_MutationNAA383V0.29
BRCAchr1549134035Silentrs372907163K263K0.29
CESCchr1549134086Missense_MutationnovelL246F0.11
CESCchr1549127955Missense_MutationNAA443T0.1
CESCchr15491278543'UTRnovel0.14
CESCchr1549129477Missense_MutationNAK376N0.46
CESCchr15491259413'UTRnovel0.38
COADchr1549133812Splice_SiteNAX299_splice0.44
COADchr1549134047Frame_Shift_DelnovelF259Lfs*190.29
COADchr15491278213'UTRnovel0.31
COADchr1549127984Missense_MutationNAS433Y0.32
COADchr1549139602SilentNAR100R0.28
COADchr1549128082SilentnovelG400G0.32
COADchr1549134484Frame_Shift_InsnovelG191Rfs*210.11
COADchr1549144989Frame_Shift_DelnovelA49Rfs*30.39
COADchr1549137164Frame_Shift_InsnovelH176Tfs*70.14
COADchr1549137178Missense_MutationNAI171N0.37
COADchr1549134361Silentrs780336002L232L0.82
COADchr15491555995'UTRnovel0.2
GBMchr15491555995'UTRnovel0.17
GBMchr15491558965'Flanknovel0.62
GBMchr1549130801Missense_MutationnovelN321K0.15
HNSCchr1549128735In_Frame_DelnovelI380_V385delinsM0.12
HNSCchr1549134047Frame_Shift_DelnovelF259Lfs*190.27
HNSCchr1549155566Missense_MutationnovelE5Q0.1
HNSCchr1549137430Frame_Shift_DelnovelL127Tfs*60.07
HNSCchr1549144273Nonsense_MutationNAW67*0.32
KIRCchr1549128024Nonsense_MutationNAR420*0.07
KIRCchr1549137190Missense_MutationNAK167R0.16
KIRPchr1549129530Missense_MutationNAL359F0.42
LGGchr1549155574Missense_MutationNAS2C0.48
LGGchr1549134420In_Frame_DelnovelN211del0.1
LGGchr1549134063Missense_MutationnovelA254V0.37
LUADchr1549155548Missense_MutationnovelD11H0.32
LUADchr1549134084Missense_MutationNAR247T0.2
LUADchr1549139628Missense_MutationNAR91T0.15
LUADchr1549139601Missense_MutationNAR100L0.4
LUADchr15491556105'UTRnovel0.3
LUADchr15491555915'UTRrs1910668530.18
LUADchr1549134341Splice_RegionnovelR238R0.38
LUSCchr15491556595'FlankNA0.4
LUSCchr1549133761Splice_RegionNAV315V0.3
LUSCchr1549134006Missense_MutationnovelR273Q0.78
LUSCchr1549137228Splice_SiteNAX155_splice0.19
LUSCchr1549133787Missense_Mutationrs758202372E307Q0.12
LUSCchr15491556595'FlankNA0.36
LUSCchr1549128712Missense_MutationNAI393V0.38
OVchr1549145013SilentnovelK40K0.04
OVchr1549155578Translation_Start_SitenovelM1?0.95
PAADchr15491558535'Flanknovel0.14
PAADchr1549139602Missense_Mutationrs745372669R100W0.07
READchr15491558595'Flanknovel0.43
READchr1549134019Missense_MutationNAG269R0.33
READchr1549134414Missense_MutationNAL214R0.35
SARCchr1549139605Missense_MutationnovelI99F0.4
SKCMchr15491556595'FlankNA0.33
SKCMchr1549139568Missense_MutationnovelS111F0.59
SKCMchr1549144273Nonsense_MutationNAW67*0.13
SKCMchr1549128727SilentNAL388L0.14
SKCMchr1549139559Missense_MutationNAS114F0.28
SKCMchr1549144971SilentNAF54F0.19
SKCMchr1549144981Missense_MutationNAL51S0.23
SKCMchr15491559285'Flanknovel0.38
SKCMchr15491556595'FlankNA0.33
SKCMchr1549134029Nonsense_MutationNAY265*0.1
SKCMchr1549144271Missense_MutationNAG68R0.29
SKCMchr1549130809Nonsense_MutationNAQ319*0.19
STADchr15491558295'Flanknovel0.31
STADchr1549130722Missense_MutationNAE348K0.28
STADchr1549139602Missense_Mutationrs745372669R100W0.39
STADchr1549130716Splice_Regionnovel0.27
STADchr1549144267Missense_MutationNAF69C0.3
STADchr1549134072Missense_MutationNAF251C0.84
STADchr1549133803Silentrs148364582P301P0.38
STADchr1549134046Frame_Shift_InsnovelE260*0.24
STADchr1549134047Frame_Shift_DelnovelF259Lfs*190.35
STADchr15491556365'UTRrs1412868140.32
STADchr1549134484Frame_Shift_InsnovelG191Rfs*210.24
STADchr1549139603Missense_MutationnovelI99M0.24
STADchr15491559705'Flanknovel0.18
UCECchr1549134480Missense_MutationNAT192I0.22
UCECchr15491274013'UTRnovel0.17
UCECchr1549133770Silentrs778626729T312T0.15
UCECchr1549139543SilentnovelI119I0.06
UCECchr1549137156SilentnovelS178S0.32
UCECchr1549139617Missense_MutationnovelL95I0.46
UCECchr1549134046Frame_Shift_InsnovelE260*0.23
UCECchr15491263283'UTRnovel0.21
UCECchr15491271923'UTRnovel0.33
UCECchr1549134051Missense_MutationNAF258C0.42
UCECchr1549128046Missense_MutationNAD412E0.31
UCECchr1549134055Missense_MutationNAD257Y0.33
UCECchr15491274753'UTRnovel0.24
UCECchr1549134338Splice_SitenovelX239_splice0.15
UCECchr1549127984Missense_MutationNAS433Y0.38
UCECchr1549133958Missense_MutationNAS289L0.49
UCECchr1549139543SilentnovelI119I0.54
UCECchr1549145025Nonsense_MutationnovelY36*0.44
UCECchr1549133958Missense_MutationNAS289L0.32
UCECchr1549128074Missense_MutationNAD403V0.41
UCECchr1549144297Missense_MutationnovelE59G0.05
UCECchr15491262943'UTRnovel0.08
UCECchr15491265193'UTRnovel0.22
UCECchr15491274093'UTRnovel0.18
UCECchr1549139553Missense_MutationnovelL116R0.19
UCECchr15491558965'Flanknovel0.15
UCECchr15491276273'UTRnovel0.41
UCECchr15491260963'UTRnovel0.5
UCECchr15491278643'UTRnovel0.26
UCECchr1549139577Missense_MutationnovelS108Y0.45
UCECchr15491263453'UTRnovel0.56
UCECchr15491265463'UTRnovel0.36
UCECchr1549127984Missense_MutationNAS433Y0.12
UCECchr1549133989Missense_MutationnovelY279H0.1
UCECchr1549137178Missense_MutationNAI171N0.37
UCECchr15491275193'UTRnovel0.59
UCECchr1549137178Missense_MutationNAI171N0.17
UCECchr1549134071Nonsense_MutationnovelE252Rfs*30.08
UCECchr15491559855'Flanknovel0.49
UCECchr1549134481Nonsense_MutationnovelG191_T192insGSFLYGLA*0.04
UCECchr1549130747SilentnovelD339D0.3
UCECchr1549134435Missense_MutationnovelA207V0.23
UCECchr1549139543SilentnovelI119I0.44
UCECchr1549134092Missense_MutationnovelM244I0.48
UCECchr15491274603'UTRnovel0.38
UCECchr1549134007Nonsense_MutationNAR273*0.45
UCECchr15491555995'UTRnovel0.45
UCECchr15491277293'UTRnovel0.36
UCECchr1549128081Nonsense_MutationnovelR401*0.49
UCECchr1549134464Missense_MutationnovelI197M0.07

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.21110.079424
CESCDEL0.18640.00049652
HNSCDEL0.15710.11567
KICHAMP0.27270.21756
KIRPDEL0.10070.2062
LIHCDEL0.1733.0903e-07
LUADDEL0.35850.050802
MESODEL0.14940.075661
PAADDEL0.11960.13216
READDEL0.44240.025797

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.019

Kaplan-Meier Survival Analysis

ACC0.032

Kaplan-Meier Survival Analysis

HNSC0.0012

Kaplan-Meier Survival Analysis

SKCM0.0011

Kaplan-Meier Survival Analysis

KIRP0.0015

Kaplan-Meier Survival Analysis

PAAD0.0048

Kaplan-Meier Survival Analysis

PCPG0.019

Kaplan-Meier Survival Analysis

KICH0.028

Kaplan-Meier Survival Analysis

DLBC0.014

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000166200 (Gene tree)
Gene ID
9318
Gene Symbol
COPS2
Alias
TRIP15|ALIEN|CSN2
Full Name
COP9 signalosome subunit 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
49,594 bases
Position
chr15:49,106,068-49,155,661
Accession
30747
RBP type
non-canonical RBP
Summary
(COP9 Signalosome Subunit 2) is a Protein Coding gene. Diseases associated with COPS2 include Xeroderma Pigmentosum, Complementation Group E and Decubitus Ulcer. Among its related pathways are Clathrin-mediated endocytosis and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transcription corepressor activity. An important paralog of this gene is PSMD11.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24928548Gene expression analysis in MCF-7 breast cancer cells treated with recombinant bromelain.Appl Biochem Biotechnol2014 AugFouz Ndoi: 10.1007/s12010-014-0947-6
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000561248COPS2-208575-ENSP00000453412183 (aa)-H0YM03
ENST00000560240COPS2-207514-ENSP0000045354655 (aa)-H0YMC2
ENST00000542928COPS2-2031580-ENSP00000443664379 (aa)-B4DIH5
ENST00000299259COPS2-2012036-ENSP00000299259450 (aa)-P61201
ENST00000388901COPS2-2026628-ENSP00000373553443 (aa)-P61201
ENST00000559016COPS2-206570--- (aa)--
ENST00000558545COPS2-204668--- (aa)--
ENST00000558843COPS2-205803-ENSP00000452944263 (aa)-H0YKU5
Gene Model
Click here to download ENSG00000166200's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000166200rs792340941549117330ALung function (FEV1/FVC)30804560[0.022-0.032] unit increase0.0268EFO_0004713
ENSG00000166200rs792340941549117330APeak expiratory flow30804560[0.015-0.027] unit increase0.0209
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166200's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000166200COPS2100100.000ENSMUSG00000027206Cops2100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-IEAProcess
GO:0000338protein deneddylation19141280.IDAProcess
GO:0000715nucleotide-excision repair, DNA damage recognition-TASProcess
GO:0001833inner cell mass cell proliferation-IEAProcess
GO:0003714transcription corepressor activity21873635.IBAFunction
GO:0005515protein binding17438371.20399188.21911577.23441852.24421388.25043011.IPIFunction
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm9535219.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006283transcription-coupled nucleotide-excision repair-TASProcess
GO:0006366transcription by RNA polymerase II7776974.TASProcess
GO:0006468protein phosphorylation9535219.IDAProcess
GO:0007165signal transduction9535219.NASProcess
GO:0008180COP9 signalosome21873635.IBAComponent
GO:0008180COP9 signalosome9535219.18850735.IDAComponent
GO:0030182neuron differentiation-IEAProcess
GO:0035914skeletal muscle cell differentiation-IEAProcess
GO:0043687post-translational protein modification-TASProcess
GO:0045892negative regulation of transcription, DNA-templated21873635.IBAProcess
GO:1903507negative regulation of nucleic acid-templated transcription-ISSProcess
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