EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	21043183	Missense_Mutation	NA	R64L	0.25	RnaseA
BLCA	chr14	21043585	3'UTR	novel		0.6
BRCA	chr14	21043363	Missense_Mutation	NA	K124M	0.13	RnaseA
BRCA	chr14	21043508	3'UTR	novel		0.21
BRCA	chr14	21043172	Silent	NA	K60K	0.48
BRCA	chr14	21043265	Missense_Mutation	NA	K91N	0.11	RnaseA
COAD	chr14	21043740	3'UTR	novel		0.28
COAD	chr14	21044119	3'UTR	novel		0.37
COAD	chr14	21044169	3'UTR	novel		0.42
COAD	chr14	21043302	Missense_Mutation	rs202167148	V104M	0.13	RnaseA
COAD	chr14	21043157	Frame_Shift_Ins	novel	*N57Kfs3**	0.13	RnaseA
COAD	chr14	21043405	Missense_Mutation	novel	Q138R	0.35	RnaseA
COAD	chr14	21043383	Missense_Mutation	rs371662364	V131I	0.34	RnaseA
ESCA	chr14	21044023	3'UTR	novel		0.27
GBM	chr14	21043080	Missense_Mutation	novel	P30S	0.6
GBM	chr14	21043366	Missense_Mutation	rs148716297	R125Q	0.23	RnaseA
HNSC	chr14	21043270	Missense_Mutation	novel	G93D	0.36	RnaseA
KIRC	chr14	21043231	Frame_Shift_Ins	novel	*C83Wfs16**	0.22	RnaseA
LGG	chr14	21042997	Missense_Mutation	novel	A2V	0.48
LIHC	chr14	21043316	Missense_Mutation	novel	M108I	0.45	RnaseA
LUAD	chr14	21043500	3'UTR	novel		0.31
LUAD	chr14	21043040	Silent	novel	L16L	0.3
LUAD	chr14	21043563	3'UTR	novel		0.26
LUSC	chr14	21043089	Missense_Mutation	novel	M33L	0.33
OV	chr14	21043371	Missense_Mutation	NA	N127H	0.28	RnaseA
PRAD	chr14	21043357	Missense_Mutation	NA	K122R	0.1	RnaseA
READ	chr14	21042992	5'UTR	novel		0.37
SARC	chr14	21044165	3'UTR	novel		0.19
SKCM	chr14	21043212	Missense_Mutation	rs182917147	E74K	0.22	RnaseA
SKCM	chr14	21043406	Silent	novel	Q138Q	0.34
STAD	chr14	21043354	Missense_Mutation	NA	Y121F	0.15	RnaseA
STAD	chr14	21043212	Missense_Mutation	rs182917147	E74K	0.51	RnaseA
UCEC	chr14	21043343	Silent	rs200202565	P117P	0.35
UCEC	chr14	21044124	3'UTR	novel		0.06
UCEC	chr14	21043016	Missense_Mutation	NA	F8L	0.37
UCEC	chr14	21043166	Silent	novel	I58I	0.29
UCEC	chr14	21043166	Missense_Mutation	NA	I58M	0.27	RnaseA
UCEC	chr14	21043381	Missense_Mutation	novel	Y130C	0.1	RnaseA
UCEC	chr14	21043056	Missense_Mutation	NA	A22S	0.47
UCEC	chr14	21043248	Missense_Mutation	NA	P86S	0.63	RnaseA
UCEC	chr14	21043803	3'UTR	novel		0.44
UCEC	chr14	21043422	Nonsense_Mutation	novel	Q144*	0.24	RnaseA
UCEC	chr14	21044138	3'UTR	novel		0.19
UCEC	chr14	21043741	3'UTR	novel		0.22
UCEC	chr14	21043329	Missense_Mutation	NA	S113P	0.47	RnaseA
UCEC	chr14	21043943	3'UTR	novel		0.42
UCEC	chr14	21043083	Missense_Mutation	novel	K31E	0.26
UCEC	chr14	21043172	Silent	NA	K60K	0.56
UCEC	chr14	21043316	Missense_Mutation	novel	M108I	0.52	RnaseA
UCEC	chr14	21043413	Missense_Mutation	NA	D141Y	0.43	RnaseA
UCEC	chr14	21043741	3'UTR	novel		0.21
UCEC	chr14	21043383	Missense_Mutation	rs371662364	V131I	0.61	RnaseA
UCEC	chr14	21043556	3'UTR	novel		0.1
UCEC	chr14	21043652	3'UTR	novel		0.28
UCEC	chr14	21043153	Missense_Mutation	novel	A54V	0.22	RnaseA
UCEC	chr14	21043768	3'UTR	novel		0.2
UCEC	chr14	21044135	3'UTR	rs192702066		0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2778	0.056464
ACC	DEL	0.1333	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1111	0.0025503
KIRP	DEL	0.1667	0.085174
LUSC	DEL	0.2635	0.0082553
OV	AMP	0.2124	4.811e-06
PAAD	DEL	0.0924	0.11332
READ	DEL	0.3697	0.0043084

Survival Analysis

Cancer	P-value	Q-value
THYM	0.035	Kaplan-Meier Survival Analysis
MESO	0.026	Kaplan-Meier Survival Analysis
SKCM	0.032	Kaplan-Meier Survival Analysis
BRCA	0.049	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165799 (Gene tree)
Gene ID: 84659
Gene Symbol: RNASE7
Alias: RAE1
Full Name: ribonuclease A family member 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 2,009 bases
Position: chr14:21,042,226-21,044,234
Accession: 19278
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000298690	RnaseA	PF00074.20	1.9e-39	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000481538	RNASE7-202	922	-	ENSP00000431382	156 (aa)	-	Q9H1E1
ENST00000298690	RNASE7-201	1498	-	ENSP00000298690	156 (aa)	-	Q9H1E1

Gene Model

Click here to download ENSG00000165799's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165799	Platelet Function Tests	2.4881671E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165799's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000165799	RNASE7	100	76.282	ENSG00000173431	RNASE8	100	75.641
ENSG00000165799	RNASE7	87	37.143	ENSG00000169397	RNASE3	88	37.143
ENSG00000165799	RNASE7	88	53.285	ENSG00000169413	RNASE6	91	53.285
ENSG00000165799	RNASE7	75	37.903	ENSG00000258818	RNASE4	77	37.903
ENSG00000165799	RNASE7	74	36.066	ENSG00000129538	RNASE1	86	37.963
ENSG00000165799	RNASE7	76	32.283	ENSG00000214274	ANG	76	32.283
ENSG00000165799	RNASE7	87	39.716	ENSG00000169385	RNASE2	88	39.716

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165799	RNASE7	100	80.128	ENSANAG00000010473	RNASE8	100	80.128	Aotus_nancymaae
ENSG00000165799	RNASE7	100	62.179	ENSTSYG00000009702	-	100	62.179	Carlito_syrichta
ENSG00000165799	RNASE7	100	75.000	ENSCSAG00000000341	RNASE8	100	74.359	Chlorocebus_sabaeus
ENSG00000165799	RNASE7	100	53.939	ENSFCAG00000038708	-	98	53.333	Felis_catus
ENSG00000165799	RNASE7	100	98.077	ENSGGOG00000042974	RNASE7	100	98.077	Gorilla_gorilla
ENSG00000165799	RNASE7	100	74.359	ENSSTOG00000021538	-	100	74.359	Ictidomys_tridecemlineatus
ENSG00000165799	RNASE7	100	78.481	ENSOGAG00000001147	-	100	78.481	Otolemur_garnettii
ENSG00000165799	RNASE7	100	76.923	ENSPPAG00000022422	RNASE8	100	76.923	Pan_paniscus
ENSG00000165799	RNASE7	100	98.077	ENSPPAG00000033312	RNASE7	100	98.077	Pan_paniscus
ENSG00000165799	RNASE7	100	75.949	ENSPTRG00000030802	RNASE8	100	75.949	Pan_troglodytes
ENSG00000165799	RNASE7	100	98.077	ENSPTRG00000048912	RNASE7	100	98.077	Pan_troglodytes
ENSG00000165799	RNASE7	100	75.641	ENSPPYG00000005588	RNASE8	100	75.641	Pongo_abelii
ENSG00000165799	RNASE7	100	94.231	ENSPPYG00000005587	RNASE7	100	94.231	Pongo_abelii
ENSG00000165799	RNASE7	100	79.487	ENSRBIG00000034590	RNASE8	100	78.846	Rhinopithecus_bieti
ENSG00000165799	RNASE7	100	79.487	ENSRROG00000025981	RNASE8	100	78.846	Rhinopithecus_roxellana
ENSG00000165799	RNASE7	100	76.433	ENSSBOG00000035350	RNASE8	86	76.433	Saimiri_boliviensis_boliviensis
ENSG00000165799	RNASE7	97	75.000	ENSTBEG00000005176	-	100	73.548	Tupaia_belangeri
ENSG00000165799	RNASE7	66	64.078	ENSUAMG00000011106	-	63	64.078	Ursus_americanus
ENSG00000165799	RNASE7	99	57.962	ENSVPAG00000005213	-	99	57.962	Vicugna_pacos

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001530	lipopolysaccharide binding	20180804.	IDA	Function
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004519	endonuclease activity	-	IEA	Function
GO:0004540	ribonuclease activity	21873635.	IBA	Function
GO:0004540	ribonuclease activity	12244054.19641608.	IDA	Function
GO:0005576	extracellular region	19641608.23302724.	IDA	Component
GO:0005576	extracellular region	12244054.	NAS	Component
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	25075772.	IDA	Component
GO:0005737	cytoplasm	25075772.	IDA	Component
GO:0019730	antimicrobial humoral response	-	TAS	Process
GO:0019731	antibacterial humoral response	23302724.25075772.	IDA	Process
GO:0042834	peptidoglycan binding	20180804.	IDA	Function
GO:0045087	innate immune response	16940129.23302724.25075772.	IDA	Process
GO:0045087	innate immune response	12244054.	NAS	Process
GO:0050829	defense response to Gram-negative bacterium	12244054.16940129.20180804.23302724.25075772.	IDA	Process
GO:0050830	defense response to Gram-positive bacterium	12244054.16940129.19641608.20180804.23302724.25075772.	IDA	Process
GO:0050832	defense response to fungus	12244054.	IDA	Process
GO:0051673	membrane disruption in other organism	20180804.23302724.	IDA	Process
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	12244054.25075772.	IDA	Process
GO:0090501	RNA phosphodiester bond hydrolysis	-	IEA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.