EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28633434PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes.Carcinogenesis2017 Oct 1Singh DKdoi: 10.1093/carcin/bgx062.
26840454Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.Oncotarget2016 Feb 9French JDdoi: 10.18632/oncotarget.7047.
26771192LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.PLoS One2016 Jan 15Basu Adoi: 10.1371/journal.pone.0146549
23138933Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).Mol Carcinog2014 AprXu Xdoi: 10.1002/mc.21977
22647853LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway.Cell Death Dis2012 May 31Bhargavan Bdoi: 10.1038/cddis.2012.57.
22276150Expression of the stress response oncoprotein LEDGF/p75 in human cancer: a study of 21 tumor types.PLoS One2012Basu Adoi: 10.1371/journal.pone.0030132
24604027Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene.PLoS Pathog2014 Mar 6Leitz Jdoi: 10.1371/journal.ppat.1003957
28212536Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes.Oncotarget2017 Apr 11R??os-Col??n Ldoi: 10.18632/oncotarget.15323.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr915478497Silentrs779367444P203P0.07
BLCAchr915472669Nonsense_MutationNAR314*0.86
BLCAchr915490125Splice_SiteNAX50_splice1
BLCAchr915466856Nonsense_MutationnovelS475*0.35
BLCAchr915469045Missense_MutationNAC373F0.66
BLCAchr915469318Missense_Mutationrs769340196R351Q0.4
BLCAchr915506560Splice_Siters749700330X50_splice0.47
BLCAchr915468844Splice_SiteNAX403_splice0.88
BLCAchr915474014Missense_MutationNAE285K0.14
BLCAchr915474230Nonsense_MutationnovelE213*0.98
BLCAchr915486847Nonsense_MutationnovelE125*0.51
BLCAchr9155102005'UTRNA0.44
BLCAchr915479599Frame_Shift_DelnovelP178Hfs*190.49
BLCAchr915489996Nonsense_MutationnovelS93*0.93
BLCAchr915474138Frame_Shift_DelnovelD242Afs*70.46
BLCAchr915490018Frame_Shift_InsnovelN86Lfs*60.49
BLCAchr915468980Missense_MutationnovelE395Q0.46
BLCAchr915468759Missense_MutationnovelE431K0.81
BLCAchr915474051Frame_Shift_DelnovelT272Ifs*40.38
BLCAchr915486889Missense_MutationNAE111K0.37
BLCAchr915486847Missense_MutationnovelE125K0.19
BLCAchr915510159Silentrs139542300L10L0.36
BRCAchr915490115Frame_Shift_InsNAL53Ffs*130.45
BRCAchr915490116Frame_Shift_DelNAL53*0.4
BRCAchr915472688SilentnovelH307H0.1
BRCAchr915472726Missense_MutationNAQ295E0.33
BRCAchr915472751Splice_SiteNAX287_splice0.33
BRCAchr915490028Missense_MutationNAW82C0.14
BRCAchr915469018Missense_MutationNAS382L0.28
BRCAchr915489985Splice_SiteNAX96_splice0.16
BRCAchr915486063SilentNAV133V0.16
CESCchr9155102365'UTRnovel0.23
CESCchr9154652963'UTRnovel0.14
CESCchr915490012Missense_MutationNAP88S0.3
CESCchr915486010Missense_MutationNAR151K0.25
CESCchr9155102275'UTRrs7602044240.38
CHOLchr915468840SilentnovelR404R0.33
COADchr915471250Intronnovel0.33
COADchr915465538Missense_MutationnovelD525E0.32
COADchr915474181Frame_Shift_DelnovelK229Sfs*360.45
COADchr915465558Frame_Shift_Delrs768872267E518Lfs*50.27
COADchr915474032In_Frame_Delrs757199981E278del0.44
COADchr915471199Intronrs7791962750.26
COADchr915471200Intronrs7485224010.45
COADchr915479659Missense_MutationNAA162V0.4
COADchr915506624Missense_MutationNAP29H0.35
COADchr915490116Frame_Shift_DelNAL53*0.42
COADchr915468954Splice_Regionnovel0.08
COADchr915468722Missense_MutationNAS443Y0.29
COADchr915486916Missense_MutationnovelS102P0.07
GBMchr9154654973'UTRnovel0.74
GBMchr9154654993'UTRnovel0.74
GBMchr9154654533'UTRnovel0.19
GBMchr9154654513'UTRnovel0.17
GBMchr9155102055'UTRnovel0.06
GBMchr9155102185'UTRnovel0.57
HNSCchr915468730Silentrs755366665L440L0.18
HNSCchr9154654923'UTRnovel0.25
HNSCchr915472706Frame_Shift_InsnovelN301Kfs*80.83
HNSCchr915486862Frame_Shift_DelnovelE120Kfs*140.12
HNSCchr915478478Frame_Shift_DelnovelE207Sfs*550.24
HNSCchr915469060Splice_SitenovelX369_splice0.37
HNSCchr915465563Missense_MutationnovelR517T0.15
HNSCchr915469034Frame_Shift_InsnovelD378Gfs*20.4
HNSCchr915506634Missense_MutationnovelD26H0.35
HNSCchr915472713Missense_MutationnovelR299T0.41
HNSCchr915486046Missense_MutationnovelI139T0.67
HNSCchr915468797Missense_MutationnovelM418K0.13
KIRPchr915472715Missense_MutationnovelH298Q0.09
KIRPchr915474061Frame_Shift_InsnovelV269Gfs*80.16
KIRPchr915468984Frame_Shift_DelnovelH393Qfs*40.55
LGGchr915469948In_Frame_DelnovelE341del0.3
LGGchr915506558Splice_Regionnovel0.15
LGGchr915479600Nonsense_MutationNAR182*0.36
LIHCchr915471199Intronrs7791962750.29
LIHCchr915506560Splice_SiteNAX50_splice0.25
LIHCchr915471264Intronnovel0.06
LIHCchr915472660Missense_MutationnovelK317Q0.56
LIHCchr915469959Nonsense_MutationnovelK338*0.43
LUADchr915469014SilentNAL383L0.14
LUADchr915468706Frame_Shift_DelnovelQ447Hfs*210.19
LUADchr915479609Missense_MutationnovelK179E0.05
LUADchr915468841Missense_Mutationrs761406442I403M0.53
LUADchr915486867Nonsense_MutationnovelS118*0.06
LUADchr915506587Silentrs779267116P41P0.16
LUADchr915486915Nonsense_MutationNAS102*0.16
LUADchr915468720Missense_MutationnovelL444V0.09
LUADchr915472680Missense_Mutationrs200120477E310A0.24
LUADchr915471118Intronnovel0.16
LUSCchr915468707Missense_MutationnovelR448T0.32
LUSCchr915468839Missense_MutationNAR404P0.39
LUSCchr915474127Frame_Shift_DelnovelK246Afs*30.36
LUSCchr915474133Missense_MutationnovelR245K0.38
LUSCchr915486919Nonsense_MutationnovelQ101*0.41
OVchr9154654973'UTRnovel0.11
OVchr915468840Frame_Shift_DelnovelR404Gfs*80.67
OVchr915468840Missense_MutationNAR404G0.22
PRADchr9155102735'UTRnovel0.32
PRADchr915478517Missense_MutationnovelP197S0.4
READchr915510171Missense_MutationnovelK6N0.22
READchr915479606SilentnovelR180R0.18
SARCchr9154654463'UTRnovel0.84
SKCMchr915472712Frame_Shift_DelnovelR299Kfs*90.85
SKCMchr9154654253'UTRnovel0.58
SKCMchr915469279Missense_MutationNAK364R0.6
SKCMchr915468715SilentNAA445A0.22
SKCMchr9155102595'UTRnovel0.96
SKCMchr915469325Missense_MutationNAD349N0.9
SKCMchr915472669Nonsense_MutationNAR314*0.4
SKCMchr915486018SilentNAG148G0.08
STADchr9155102075'UTRrs7684953430.14
STADchr915468823Frame_Shift_DelnovelS409Rfs*20.21
STADchr915468957Frame_Shift_DelnovelI403Yfs*90.34
STADchr915468840Missense_MutationNAR404W0.3
STADchr915472669Frame_Shift_DelnovelR314Efs*570.04
STADchr915474208Missense_MutationNAK220R0.22
STADchr915479600Nonsense_MutationNAR182*0.04
STADchr915479642Missense_Mutationrs769897877A168T0.07
STADchr915471289Intronrs7708886880.11
STADchr915486043Missense_MutationnovelT140S0.24
STADchr915468794Missense_MutationNAL419W0.15
THYMchr9155102775'UTRnovel0.19
UCECchr915471304Intronrs7596036000.3
UCECchr915471208Intronnovel0.38
UCECchr9154653803'UTRnovel0.39
UCECchr915471251Intronrs7805731330.4
UCECchr915474047Missense_Mutationrs751647340D274N0.16
UCECchr915506561Missense_Mutationrs769181268T50I0.34
UCECchr9154651463'UTRnovel0.33
UCECchr9154655153'UTRnovel0.1
UCECchr915486859Missense_MutationNAD121Y0.46
UCECchr915490044Missense_MutationNAF77C0.4
UCECchr915506598Missense_MutationNAN38H0.44
UCECchr915466835Missense_MutationNAS482Y0.28
UCECchr915471244Intronrs7565605920.44
UCECchr915506628Missense_MutationnovelV28F0.38
UCECchr915472720Missense_MutationNAA297T0.23
UCECchr915486005Splice_SiteNAX152_splice0.43
UCECchr915472734Missense_MutationNAR292M0.31
UCECchr915468685Missense_MutationnovelK455N0.2
UCECchr915472713Missense_MutationnovelR299K0.19
UCECchr9154654793'UTRnovel0.41
UCECchr915466786Missense_MutationNAE498D0.47
UCECchr915472663Missense_MutationNAR316C0.1
UCECchr915474068Frame_Shift_DelnovelT267Qfs*370.36
UCECchr915469268Missense_MutationnovelL368I0.45
UCECchr915471311Intronnovel0.43
UCECchr915474204SilentNAG221G0.33
UCECchr915472663Missense_MutationNAR316C0.41
UCECchr915471081Intronrs7639950260.46
UCECchr9154653393'UTRnovel0.08
UCECchr915468692Missense_Mutationrs763000735A453V0.44
UCECchr9154650653'UTRnovel0.33
UCECchr915466752Missense_MutationnovelK510E0.28
UCECchr9154652633'UTRnovel0.43
UCECchr915466753Missense_MutationnovelK509N0.4
UCECchr915466796Missense_MutationNAE495G0.05
UCECchr915471203Intronrs7581334430.32
UCECchr915471081Intronrs7639950260.5
UCECchr915471204Intronnovel0.2
UCECchr915472669Nonsense_MutationNAR314*0.17
UCECchr915474077Missense_MutationnovelL264V0.14
UCECchr9154650163'UTRnovel0.28
UCECchr915479688Splice_SitenovelX153_splice0.41
UCECchr915474087In_Frame_InsnovelS259_K260insNTVVLELKYSLQGKKEVES0
UCECchr9154654913'UTRnovel0.1
UCECchr915468973Missense_MutationNAI397S0.43
UCECchr915471194Intronnovel0.35
UCECchr915466801Missense_MutationNAN493K0.39
UCECchr915490066Missense_MutationNAK70Q0.29
UCECchr915474043Missense_MutationnovelS275Y0.05
UCECchr915479654Missense_MutationnovelV164L0.25
UCECchr915469941Nonsense_MutationNAR344*0.48
UCECchr915472663Missense_MutationNAR316C0.28
UCECchr915478480Missense_MutationnovelD209G0.41
UCECchr9154641453'UTRnovel0.23
UVMchr915506614SilentnovelA32A0.06

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.00520.24147
TGCTDEL0.34677.3329e-05
THCADEL0.03010.24038
THYMDEL0.03250.022012

Survival Analysis
CancerP-value Q-value
KIRC0.00025

Kaplan-Meier Survival Analysis

ACC0.0015

Kaplan-Meier Survival Analysis

SKCM0.0086

Kaplan-Meier Survival Analysis

PRAD0.018

Kaplan-Meier Survival Analysis

ESCA0.048

Kaplan-Meier Survival Analysis

PAAD0.0041

Kaplan-Meier Survival Analysis

CESC0.0034

Kaplan-Meier Survival Analysis

KICH0.046

Kaplan-Meier Survival Analysis

UCEC0.019

Kaplan-Meier Survival Analysis

LIHC0.0038

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

OV0.0088

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000164985 (Gene tree)
Gene ID
11168
Gene Symbol
PSIP1
Alias
p52|LEDGF|p75|DFS70|PSIP2
Full Name
PC4 and SFRS1 interacting protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
46,954 bases
Position
chr9:15,464,066-15,511,019
Accession
9527
RBP type
non-canonical RBP
Summary
(PC4 And SFRS1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with PSIP1 include Dermatitis, Atopic. Among its related pathways are Chromatin Regulation / Acetylation and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is HDGFL2.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26545813LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.Genes Dev2015 Nov 1Singh PKdoi: 10.1101/gad.267609.115.
20484370High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region.Nucleic Acids Res2010 OctDe Rijck Jdoi: 10.1093/nar/gkq410
23938467Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.Mol Cell Proteomics2013 NovChapman KMdoi: 10.1074/mcp.M113.030585
26367869Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.PLoS One2015 Sep 14Wang Hdoi: 10.1371/journal.pone.0137797
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000487363PSIP1-209660--- (aa)--
ENST00000397519PSIP1-2051664-ENSP00000380653333 (aa)-O75475
ENST00000463712PSIP1-206730--- (aa)--
ENST00000380716PSIP1-2021889XM_024447399ENSP00000370092333 (aa)XP_024303167O75475
ENST00000380715PSIP1-2011966XM_024447401ENSP00000370091329 (aa)XP_024303169O75475
ENST00000481862PSIP1-207306-ENSP0000047707765 (aa)-V9GYT7
ENST00000380733PSIP1-2033391-ENSP00000370109530 (aa)-O75475
ENST00000484265PSIP1-2082065--- (aa)--
ENST00000380738PSIP1-2043364-ENSP00000370114530 (aa)-O75475
ENST00000495873PSIP1-211863--- (aa)--
ENST00000488797PSIP1-210736--- (aa)--
Gene Model
Click here to download ENSG00000164985's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164985's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000164985PSIP110092.492ENSMUSG00000028484Psip1100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000395mRNA 5'-splice site recognition9885563.IDAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding21156026.22748127.22773103.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005829cytosol-TASComponent
GO:0006979response to oxidative stress-ISSProcess
GO:0009408response to heat-ISSProcess
GO:0035327transcriptionally active chromatin-ISSComponent
GO:0051169nuclear transport-TASProcess
GO:0075713establishment of integrated proviral latency-TASProcess
GO:0097100supercoiled DNA binding-ISSFunction
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