EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26733164ABCE1 plays an essential role in lung cancer progression and metastasis.Tumour Biol2016 JunTian Ydoi: 10.1007/s13277-015-4713-3
23008114The biological regulation of ABCE1.IUBMB Life2012 OctTian Ydoi: 10.1002/iub.1071.
18189233RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.Prostate2008 Mar 1Shea PRdoi: 10.1002/pros.20687.
26617714MicroRNA-299-3p promotes the sensibility of lung cancer to doxorubicin through directly targeting ABCE1.Int J Clin Exp Pathol2015 Sep 1Zheng D-
20372810A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer.Int J Mol Med2010 MayHuang B-
25744244Downregulation of ABCE1 via siRNA affects the sensitivity of A549 cells against chemotherapeutic agents.Med Oncol2015 AprKara Gdoi: 10.1007/s12032-015-0557-3
25337191Knock-down of ABCE1 gene induces G1/S arrest in human oral cancer cells.Int J Clin Exp Pathol2014 Aug 15Wang L-
26600528Effect of ABCE1-silencing gene, transfected by electrotransfer, on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells.Genet Mol Res2015 Nov 23Qu Xdoi: 10.4238/2015.November.18.32.
15809757ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients.Oncol Rep2005 MayShichijo S-
25815591Effects of silencing the ATP-binding cassette protein E1 gene by electroporation on the proliferation and migration of EC109 human esophageal cancer cells.Mol Med Rep2015 JulLi XRdoi: 10.3892/mmr.2015.3512

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr4145105633Missense_Mutationrs748937474Q44H0.14
BLCAchr4145121375Missense_MutationnovelI416S0.5
BLCAchr4145120147Missense_MutationnovelE380K0.33
BLCAchr4145110236Missense_MutationnovelA180E0.35
BLCAchr4145110400Missense_MutationnovelR190Q0.86
BLCAchr4145125054Missense_MutationNAD569N0.18
BLCAchr41451043965'UTRnovel0.12
BLCAchr4145110103Missense_MutationnovelD136N0.19
BRCAchr4145117361Missense_MutationNAY290C0.35
BRCAchr4145104493Missense_MutationNAK27N0.16
BRCAchr4145123302Missense_MutationnovelP488A0.3
BRCAchr4145110148Missense_MutationnovelE151K0.21
CESCchr41451282863'UTRnovel0.44
CESCchr4145123553SilentnovelR531R0.65
COADchr4145119941Frame_Shift_DelNAL313Wfs*100.22
COADchr4145123484Missense_MutationnovelI508M0.4
COADchr4145109191Missense_MutationNAK116M0.33
COADchr4145110230Missense_MutationNAK178R0.42
COADchr4145123030Missense_Mutationrs550948053R425C0.13
COADchr4145120047SilentNAC346C0.33
COADchr4145123356Frame_Shift_InsnovelR506Pfs*240.05
COADchr4145104509Nonsense_MutationNAR33*0.5
COADchr4145121637Intronnovel0.43
COADchr4145109137Missense_MutationNAP98L0.29
ESCAchr4145108091Missense_MutationNAA89V0.36
GBMchr4145108029Silentrs200854319G68G0.29
GBMchr4145110193Missense_MutationnovelA166P0.12
GBMchr4145120148Missense_MutationnovelE380V0.39
GBMchr4145127533Missense_MutationnovelE587G0.08
HNSCchr4145110397Missense_MutationnovelD189A0.3
HNSCchr4145112313Missense_MutationnovelL262P0.36
HNSCchr4145123500Missense_MutationnovelT514A0.29
HNSCchr4145119941Frame_Shift_DelNAL313Wfs*100.3
KICHchr4145123540Missense_MutationnovelY527C0.04
KICHchr4145123288Missense_MutationnovelY483C0.5
KIRCchr4145120060Missense_MutationNAP351T0.3
KIRPchr4145120154Splice_SitenovelX382_splice0.34
LGGchr4145110988Nonsense_MutationnovelR212*0.08
LGGchr4145123345Missense_Mutationrs201368309R502Q0.56
LGGchr4145123498Frame_Shift_InsnovelT514Dfs*80.36
LIHCchr4145112307Missense_Mutationrs752956027R260Q0.4
LIHCchr4145120037Missense_MutationnovelK343T0.49
LIHCchr4145108046Missense_MutationNAN74S0.15
LIHCchr4145110977Frame_Shift_DelnovelH208Pfs*20.37
LIHCchr4145109245Missense_MutationnovelY134C0.53
LUADchr4145110415Missense_MutationnovelK195R0.06
LUADchr4145121203Missense_MutationnovelL392F0.58
LUADchr4145121369Missense_MutationNAQ414R0.3
LUSCchr4145105619Missense_MutationNAE40Q0.25
LUSCchr4145110157Missense_MutationnovelN154H0.21
LUSCchr4145108050SilentnovelL75L0.73
PAADchr4145111057Missense_MutationnovelA235T0.18
PAADchr4145123553SilentnovelR531R0.19
PRADchr4145111052Missense_MutationNAQ233P0.07
READchr4145108082Missense_MutationNAR86Q0.26
READchr4145123030Missense_Mutationrs550948053R425C0.21
READchr4145109200Missense_MutationnovelA119G0.33
SARCchr41451278833'UTRnovel0.33
SKCMchr4145121338Missense_MutationNAV404I0.17
SKCMchr4145125044SilentnovelT565T0.26
SKCMchr4145108023SilentNAP66P0.3
SKCMchr4145121387Missense_MutationNAS420L0.5
SKCMchr4145110106Missense_Mutationrs755429648P137S0.21
SKCMchr4145123566Missense_MutationnovelD536N0.16
SKCMchr4145104445SilentNAV11V0.13
SKCMchr4145123102SilentNAL449L0.28
SKCMchr4145109142Missense_MutationNAP100S0.15
SKCMchr4145123481SilentNAF507F0.41
SKCMchr4145123020Splice_SiteNAX422_splice0.47
SKCMchr4145110208Nonsense_MutationNAQ171*0.55
SKCMchr4145110979SilentNAL209L0.56
SKCMchr4145108081Nonsense_MutationNAR86*0.28
SKCMchr4145110106Missense_Mutationrs755429648P137S0.41
STADchr4145120072Frame_Shift_DelNAM357Wfs*60.19
STADchr4145104472SilentNAK20K0.22
STADchr4145123554Missense_Mutationrs201425980V532I0.26
STADchr4145119941Frame_Shift_DelNAL313Wfs*100.44
STADchr4145104484SilentnovelE24E0.41
STADchr41451276273'UTRnovel0.41
STADchr4145123357Missense_MutationnovelR506H0.48
STADchr4145111036Missense_MutationnovelA228T0.35
STADchr4145117374Silentrs200036682S294S0.28
STADchr4145120072Frame_Shift_DelNAM357Wfs*60.28
STADchr4145120150Missense_MutationNAN381Y0.35
STADchr4145119941Frame_Shift_DelNAL313Wfs*100.21
STADchr41451044055'UTRnovel0.38
STADchr4145120072Frame_Shift_DelNAM357Wfs*60.22
STADchr4145111043Missense_MutationnovelV230G0.37
STADchr4145119941Frame_Shift_DelNAL313Wfs*100.43
UCECchr41451044045'UTRrs5659471080.09
UCECchr4145110988Nonsense_MutationnovelR212*0.34
UCECchr41451278823'UTRnovel0.53
UCECchr4145123030Missense_Mutationrs550948053R425C0.3
UCECchr4145127561Missense_MutationNAF596L0.38
UCECchr41451282053'UTRnovel0.46
UCECchr4145104509Nonsense_MutationNAR33*0.4
UCECchr4145110399Nonsense_MutationnovelR190*0.34
UCECchr41451279623'UTRnovel0.67
UCECchr4145112310Missense_MutationnovelS261Y0.16
UCECchr4145108091Missense_MutationNAA89V0.21
UCECchr4145109248Missense_MutationNAD135V0.25
UCECchr4145120141SilentnovelL378L0.3
UCECchr41451277623'UTRnovel0.31
UCECchr41451277263'UTRnovel0.29
UCECchr4145123088Missense_MutationnovelD444G0.39
UCECchr41451283023'UTRnovel0.24
UCECchr4145121382SilentnovelP418P0.36
UCECchr4145123356Missense_Mutationrs745538246R506C0.21
UCECchr4145125075Nonsense_MutationnovelR576*0.36
UCECchr4145121347Missense_MutationnovelL407I0.36
UCECchr41451282173'UTRnovel0.29
UCECchr41451275993'UTRnovel0.46
UCECchr4145120010Missense_MutationNAA334V0.32
UCECchr4145104509Nonsense_MutationNAR33*0.24
UCECchr4145117323SilentnovelS277S0.14
UCECchr41451280593'UTRnovel0.27
UCECchr41451282463'UTRnovel0.11
UCECchr4145104509Nonsense_MutationNAR33*0.43
UCECchr4145117369Missense_MutationnovelP293S0.38
UCECchr4145127561Missense_MutationNAF596L0.26
UCECchr4145121375Missense_MutationnovelI416S0.14
UCECchr41451276313'UTRnovel0.13
UCECchr41451282873'UTRnovel0.15
UCECchr4145123560Missense_MutationNAV534I0.34
UCECchr4145123553SilentnovelR531R0.38
UCECchr4145123027Missense_MutationnovelV424I0.05
UCECchr41451283113'UTRnovel0.56
UCECchr4145121365Frame_Shift_InsnovelP413Lfs*60.03
UCECchr41451282243'UTRnovel0.31
UCECchr4145110147SilentNAS150S0.38
UCECchr4145117353SilentNAC287C0.42
UCECchr41451282173'UTRnovel0.13
UCECchr41451277703'UTRnovel0.15
UCECchr4145111028Missense_MutationNAF225C0.52
UCECchr41451280003'UTRnovel0.47
UCECchr4145123493Frame_Shift_DelnovelK513Rfs*160.21
UCECchr4145123222Missense_MutationnovelT461I0.32
UCECchr4145108088Missense_MutationnovelC88Y0.37
UCECchr41451282023'UTRnovel0.24

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.13332.13e-13

Survival Analysis
CancerP-value Q-value
KIRC0.042

Kaplan-Meier Survival Analysis

SARC0.021

Kaplan-Meier Survival Analysis

MESO0.016

Kaplan-Meier Survival Analysis

ACC0.029

Kaplan-Meier Survival Analysis

HNSC0.0058

Kaplan-Meier Survival Analysis

SKCM0.012

Kaplan-Meier Survival Analysis

BRCA0.017

Kaplan-Meier Survival Analysis

KIRP0.0049

Kaplan-Meier Survival Analysis

COAD0.013

Kaplan-Meier Survival Analysis

PAAD0.00019

Kaplan-Meier Survival Analysis

CESC0.011

Kaplan-Meier Survival Analysis

READ0.0045

Kaplan-Meier Survival Analysis

KICH0.011

Kaplan-Meier Survival Analysis

LIHC0.0059

Kaplan-Meier Survival Analysis

LGG0.037

Kaplan-Meier Survival Analysis

LUAD0.0061

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000164163 (Gene tree)
Gene ID
6059
Gene Symbol
ABCE1
Alias
RLI|OABP|RLI1|RNASEL1|RNASELI|RNS4I
Full Name
ATP binding cassette subfamily E member 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
31,593 bases
Position
chr4:145,097,932-145,129,524
Accession
69
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21543480HIV Gag-leucine zipper chimeras form ABCE1-containing intermediates and RNase-resistant immature capsids similar to those formed by wild-type HIV-1 Gag.J Virol2011 JulKlein KCdoi: 10.1128/JVI.00288-11
31088929Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae.MBio2019 May 14Anderson DEdoi: 10.1128/mBio.00826-19.
24278036Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells.PLoS Genet2013 NovBeznoskova Pdoi: 10.1371/journal.pgen.1003962
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000507193ABCE1-2072146-ENSP00000422068421 (aa)-D6R9I9
ENST00000515678ABCE1-210750--- (aa)--
ENST00000296577ABCE1-2013921-ENSP00000296577599 (aa)-P61221
ENST00000509593ABCE1-208582--- (aa)--
ENST00000504292ABCE1-204625-ENSP00000423415147 (aa)-H0Y990
ENST00000506506ABCE1-206421--- (aa)--
ENST00000502586ABCE1-202786-ENSP00000421250210 (aa)-D6RGF4
ENST00000502803ABCE1-203782--- (aa)--
ENST00000504683ABCE1-205759--- (aa)--
ENST00000510321ABCE1-2092529--- (aa)--
Gene Model
Click here to download ENSG00000164163's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000164163rs177256004145106282?Peripheral arterial disease (traffic-related air pollution interaction)27082954[11.06-14.4]12.73EFO_0004265|EFO_0007908
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164163's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000164163ABCE19978.947FBgn0086706pix9877.258Drosophila_melanogaster
ENSG00000164163ABCE1100100.000ENSMUSG00000058355Abce1100100.000Mus_musculus
ENSG00000164163ABCE18979.679YDR091C9968.595Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000054ribosomal subunit export from nucleus21873635.IBAProcess
GO:0005506iron ion binding21873635.IBAFunction
GO:0005515protein binding7539425.16275648.25944354.IPIFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005737cytoplasm11585831.IDAComponent
GO:0005739mitochondrion11585831.IDAComponent
GO:0005759mitochondrial matrix-TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006413translational initiation21873635.IBAProcess
GO:0006415translational termination21873635.IBAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016032viral process-IEAProcess
GO:0016887ATPase activity-IEAFunction
GO:0043024ribosomal small subunit binding21873635.IBAFunction
GO:0051607defense response to virus-TASProcess
GO:0060338regulation of type I interferon-mediated signaling pathway-TASProcess
GO:0060698endoribonuclease inhibitor activity7539425.IDAFunction
GO:0060702negative regulation of endoribonuclease activity7539425.IDAProcess
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