EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26733164	ABCE1 plays an essential role in lung cancer progression and metastasis.	Tumour Biol	2016 Jun	Tian Y	doi: 10.1007/s13277-015-4713-3
23008114	The biological regulation of ABCE1.	IUBMB Life	2012 Oct	Tian Y	doi: 10.1002/iub.1071.
18189233	RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.	Prostate	2008 Mar 1	Shea PR	doi: 10.1002/pros.20687.
26617714	MicroRNA-299-3p promotes the sensibility of lung cancer to doxorubicin through directly targeting ABCE1.	Int J Clin Exp Pathol	2015 Sep 1	Zheng D	-
20372810	A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer.	Int J Mol Med	2010 May	Huang B	-
25744244	Downregulation of ABCE1 via siRNA affects the sensitivity of A549 cells against chemotherapeutic agents.	Med Oncol	2015 Apr	Kara G	doi: 10.1007/s12032-015-0557-3
25337191	Knock-down of ABCE1 gene induces G1/S arrest in human oral cancer cells.	Int J Clin Exp Pathol	2014 Aug 15	Wang L	-
26600528	Effect of ABCE1-silencing gene, transfected by electrotransfer, on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells.	Genet Mol Res	2015 Nov 23	Qu X	doi: 10.4238/2015.November.18.32.
15809757	ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients.	Oncol Rep	2005 May	Shichijo S	-
25815591	Effects of silencing the ATP-binding cassette protein E1 gene by electroporation on the proliferation and migration of EC109 human esophageal cancer cells.	Mol Med Rep	2015 Jul	Li XR	doi: 10.3892/mmr.2015.3512

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr4	145105633	Missense_Mutation	rs748937474	Q44H	0.14
BLCA	chr4	145121375	Missense_Mutation	novel	I416S	0.5
BLCA	chr4	145120147	Missense_Mutation	novel	E380K	0.33
BLCA	chr4	145110236	Missense_Mutation	novel	A180E	0.35
BLCA	chr4	145110400	Missense_Mutation	novel	R190Q	0.86
BLCA	chr4	145125054	Missense_Mutation	NA	D569N	0.18
BLCA	chr4	145104396	5'UTR	novel		0.12
BLCA	chr4	145110103	Missense_Mutation	novel	D136N	0.19
BRCA	chr4	145117361	Missense_Mutation	NA	Y290C	0.35
BRCA	chr4	145104493	Missense_Mutation	NA	K27N	0.16
BRCA	chr4	145123302	Missense_Mutation	novel	P488A	0.3
BRCA	chr4	145110148	Missense_Mutation	novel	E151K	0.21
CESC	chr4	145128286	3'UTR	novel		0.44
CESC	chr4	145123553	Silent	novel	R531R	0.65
COAD	chr4	145119941	Frame_Shift_Del	NA	*L313Wfs10**	0.22
COAD	chr4	145123484	Missense_Mutation	novel	I508M	0.4
COAD	chr4	145109191	Missense_Mutation	NA	K116M	0.33
COAD	chr4	145110230	Missense_Mutation	NA	K178R	0.42
COAD	chr4	145123030	Missense_Mutation	rs550948053	R425C	0.13
COAD	chr4	145120047	Silent	NA	C346C	0.33
COAD	chr4	145123356	Frame_Shift_Ins	novel	*R506Pfs24**	0.05
COAD	chr4	145104509	Nonsense_Mutation	NA	R33*	0.5
COAD	chr4	145121637	Intron	novel		0.43
COAD	chr4	145109137	Missense_Mutation	NA	P98L	0.29
ESCA	chr4	145108091	Missense_Mutation	NA	A89V	0.36
GBM	chr4	145108029	Silent	rs200854319	G68G	0.29
GBM	chr4	145110193	Missense_Mutation	novel	A166P	0.12
GBM	chr4	145120148	Missense_Mutation	novel	E380V	0.39
GBM	chr4	145127533	Missense_Mutation	novel	E587G	0.08
HNSC	chr4	145110397	Missense_Mutation	novel	D189A	0.3
HNSC	chr4	145112313	Missense_Mutation	novel	L262P	0.36
HNSC	chr4	145123500	Missense_Mutation	novel	T514A	0.29
HNSC	chr4	145119941	Frame_Shift_Del	NA	*L313Wfs10**	0.3
KICH	chr4	145123540	Missense_Mutation	novel	Y527C	0.04
KICH	chr4	145123288	Missense_Mutation	novel	Y483C	0.5
KIRC	chr4	145120060	Missense_Mutation	NA	P351T	0.3
KIRP	chr4	145120154	Splice_Site	novel	X382_splice	0.34
LGG	chr4	145110988	Nonsense_Mutation	novel	R212*	0.08
LGG	chr4	145123345	Missense_Mutation	rs201368309	R502Q	0.56
LGG	chr4	145123498	Frame_Shift_Ins	novel	*T514Dfs8**	0.36
LIHC	chr4	145112307	Missense_Mutation	rs752956027	R260Q	0.4
LIHC	chr4	145120037	Missense_Mutation	novel	K343T	0.49
LIHC	chr4	145108046	Missense_Mutation	NA	N74S	0.15
LIHC	chr4	145110977	Frame_Shift_Del	novel	*H208Pfs2**	0.37
LIHC	chr4	145109245	Missense_Mutation	novel	Y134C	0.53
LUAD	chr4	145110415	Missense_Mutation	novel	K195R	0.06
LUAD	chr4	145121203	Missense_Mutation	novel	L392F	0.58
LUAD	chr4	145121369	Missense_Mutation	NA	Q414R	0.3
LUSC	chr4	145105619	Missense_Mutation	NA	E40Q	0.25
LUSC	chr4	145110157	Missense_Mutation	novel	N154H	0.21
LUSC	chr4	145108050	Silent	novel	L75L	0.73
PAAD	chr4	145111057	Missense_Mutation	novel	A235T	0.18
PAAD	chr4	145123553	Silent	novel	R531R	0.19
PRAD	chr4	145111052	Missense_Mutation	NA	Q233P	0.07
READ	chr4	145108082	Missense_Mutation	NA	R86Q	0.26
READ	chr4	145123030	Missense_Mutation	rs550948053	R425C	0.21
READ	chr4	145109200	Missense_Mutation	novel	A119G	0.33
SARC	chr4	145127883	3'UTR	novel		0.33
SKCM	chr4	145121338	Missense_Mutation	NA	V404I	0.17
SKCM	chr4	145125044	Silent	novel	T565T	0.26
SKCM	chr4	145108023	Silent	NA	P66P	0.3
SKCM	chr4	145121387	Missense_Mutation	NA	S420L	0.5
SKCM	chr4	145110106	Missense_Mutation	rs755429648	P137S	0.21
SKCM	chr4	145123566	Missense_Mutation	novel	D536N	0.16
SKCM	chr4	145104445	Silent	NA	V11V	0.13
SKCM	chr4	145123102	Silent	NA	L449L	0.28
SKCM	chr4	145109142	Missense_Mutation	NA	P100S	0.15
SKCM	chr4	145123481	Silent	NA	F507F	0.41
SKCM	chr4	145123020	Splice_Site	NA	X422_splice	0.47
SKCM	chr4	145110208	Nonsense_Mutation	NA	Q171*	0.55
SKCM	chr4	145110979	Silent	NA	L209L	0.56
SKCM	chr4	145108081	Nonsense_Mutation	NA	R86*	0.28
SKCM	chr4	145110106	Missense_Mutation	rs755429648	P137S	0.41
STAD	chr4	145120072	Frame_Shift_Del	NA	*M357Wfs6**	0.19
STAD	chr4	145104472	Silent	NA	K20K	0.22
STAD	chr4	145123554	Missense_Mutation	rs201425980	V532I	0.26
STAD	chr4	145119941	Frame_Shift_Del	NA	*L313Wfs10**	0.44
STAD	chr4	145104484	Silent	novel	E24E	0.41
STAD	chr4	145127627	3'UTR	novel		0.41
STAD	chr4	145123357	Missense_Mutation	novel	R506H	0.48
STAD	chr4	145111036	Missense_Mutation	novel	A228T	0.35
STAD	chr4	145117374	Silent	rs200036682	S294S	0.28
STAD	chr4	145120072	Frame_Shift_Del	NA	*M357Wfs6**	0.28
STAD	chr4	145120150	Missense_Mutation	NA	N381Y	0.35
STAD	chr4	145119941	Frame_Shift_Del	NA	*L313Wfs10**	0.21
STAD	chr4	145104405	5'UTR	novel		0.38
STAD	chr4	145120072	Frame_Shift_Del	NA	*M357Wfs6**	0.22
STAD	chr4	145111043	Missense_Mutation	novel	V230G	0.37
STAD	chr4	145119941	Frame_Shift_Del	NA	*L313Wfs10**	0.43
UCEC	chr4	145104404	5'UTR	rs565947108		0.09
UCEC	chr4	145110988	Nonsense_Mutation	novel	R212*	0.34
UCEC	chr4	145127882	3'UTR	novel		0.53
UCEC	chr4	145123030	Missense_Mutation	rs550948053	R425C	0.3
UCEC	chr4	145127561	Missense_Mutation	NA	F596L	0.38
UCEC	chr4	145128205	3'UTR	novel		0.46
UCEC	chr4	145104509	Nonsense_Mutation	NA	R33*	0.4
UCEC	chr4	145110399	Nonsense_Mutation	novel	R190*	0.34
UCEC	chr4	145127962	3'UTR	novel		0.67
UCEC	chr4	145112310	Missense_Mutation	novel	S261Y	0.16
UCEC	chr4	145108091	Missense_Mutation	NA	A89V	0.21
UCEC	chr4	145109248	Missense_Mutation	NA	D135V	0.25
UCEC	chr4	145120141	Silent	novel	L378L	0.3
UCEC	chr4	145127762	3'UTR	novel		0.31
UCEC	chr4	145127726	3'UTR	novel		0.29
UCEC	chr4	145123088	Missense_Mutation	novel	D444G	0.39
UCEC	chr4	145128302	3'UTR	novel		0.24
UCEC	chr4	145121382	Silent	novel	P418P	0.36
UCEC	chr4	145123356	Missense_Mutation	rs745538246	R506C	0.21
UCEC	chr4	145125075	Nonsense_Mutation	novel	R576*	0.36
UCEC	chr4	145121347	Missense_Mutation	novel	L407I	0.36
UCEC	chr4	145128217	3'UTR	novel		0.29
UCEC	chr4	145127599	3'UTR	novel		0.46
UCEC	chr4	145120010	Missense_Mutation	NA	A334V	0.32
UCEC	chr4	145104509	Nonsense_Mutation	NA	R33*	0.24
UCEC	chr4	145117323	Silent	novel	S277S	0.14
UCEC	chr4	145128059	3'UTR	novel		0.27
UCEC	chr4	145128246	3'UTR	novel		0.11
UCEC	chr4	145104509	Nonsense_Mutation	NA	R33*	0.43
UCEC	chr4	145117369	Missense_Mutation	novel	P293S	0.38
UCEC	chr4	145127561	Missense_Mutation	NA	F596L	0.26
UCEC	chr4	145121375	Missense_Mutation	novel	I416S	0.14
UCEC	chr4	145127631	3'UTR	novel		0.13
UCEC	chr4	145128287	3'UTR	novel		0.15
UCEC	chr4	145123560	Missense_Mutation	NA	V534I	0.34
UCEC	chr4	145123553	Silent	novel	R531R	0.38
UCEC	chr4	145123027	Missense_Mutation	novel	V424I	0.05
UCEC	chr4	145128311	3'UTR	novel		0.56
UCEC	chr4	145121365	Frame_Shift_Ins	novel	*P413Lfs6**	0.03
UCEC	chr4	145128224	3'UTR	novel		0.31
UCEC	chr4	145110147	Silent	NA	S150S	0.38
UCEC	chr4	145117353	Silent	NA	C287C	0.42
UCEC	chr4	145128217	3'UTR	novel		0.13
UCEC	chr4	145127770	3'UTR	novel		0.15
UCEC	chr4	145111028	Missense_Mutation	NA	F225C	0.52
UCEC	chr4	145128000	3'UTR	novel		0.47
UCEC	chr4	145123493	Frame_Shift_Del	novel	*K513Rfs16**	0.21
UCEC	chr4	145123222	Missense_Mutation	novel	T461I	0.32
UCEC	chr4	145108088	Missense_Mutation	novel	C88Y	0.37
UCEC	chr4	145128202	3'UTR	novel		0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	2.13e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.042	Kaplan-Meier Survival Analysis
SARC	0.021	Kaplan-Meier Survival Analysis
MESO	0.016	Kaplan-Meier Survival Analysis
ACC	0.029	Kaplan-Meier Survival Analysis
HNSC	0.0058	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
BRCA	0.017	Kaplan-Meier Survival Analysis
KIRP	0.0049	Kaplan-Meier Survival Analysis
COAD	0.013	Kaplan-Meier Survival Analysis
PAAD	0.00019	Kaplan-Meier Survival Analysis
CESC	0.011	Kaplan-Meier Survival Analysis
READ	0.0045	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
LIHC	0.0059	Kaplan-Meier Survival Analysis
LGG	0.037	Kaplan-Meier Survival Analysis
LUAD	0.0061	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000164163 (Gene tree)
Gene ID: 6059
Gene Symbol: ABCE1
Alias: RLI|OABP|RLI1|RNASEL1|RNASELI|RNS4I
Full Name: ATP binding cassette subfamily E member 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 31,593 bases
Position: chr4:145,097,932-145,129,524
Accession: 69
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21543480	HIV Gag-leucine zipper chimeras form ABCE1-containing intermediates and RNase-resistant immature capsids similar to those formed by wild-type HIV-1 Gag.	J Virol	2011 Jul	Klein KC	doi: 10.1128/JVI.00288-11
31088929	Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae.	MBio	2019 May 14	Anderson DE	doi: 10.1128/mBio.00826-19.
24278036	Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells.	PLoS Genet	2013 Nov	Beznoskova P	doi: 10.1371/journal.pgen.1003962

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000507193	ABCE1-207	2146	-	ENSP00000422068	421 (aa)	-	D6R9I9
ENST00000515678	ABCE1-210	750	-	-	- (aa)	-	-
ENST00000296577	ABCE1-201	3921	-	ENSP00000296577	599 (aa)	-	P61221
ENST00000509593	ABCE1-208	582	-	-	- (aa)	-	-
ENST00000504292	ABCE1-204	625	-	ENSP00000423415	147 (aa)	-	H0Y990
ENST00000506506	ABCE1-206	421	-	-	- (aa)	-	-
ENST00000502586	ABCE1-202	786	-	ENSP00000421250	210 (aa)	-	D6RGF4
ENST00000502803	ABCE1-203	782	-	-	- (aa)	-	-
ENST00000504683	ABCE1-205	759	-	-	- (aa)	-	-
ENST00000510321	ABCE1-209	2529	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164163	rs17725600	4	145106282	?	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[11.06-14.4]	12.73	EFO_0004265\|EFO_0007908

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164163's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000164163	ABCE1	99	78.947	FBgn0086706	pix	98	77.258	Drosophila_melanogaster
ENSG00000164163	ABCE1	100	100.000	ENSMUSG00000058355	Abce1	100	100.000	Mus_musculus
ENSG00000164163	ABCE1	89	79.679	YDR091C		99	68.595	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000054	ribosomal subunit export from nucleus	21873635.	IBA	Process
GO:0005506	iron ion binding	21873635.	IBA	Function
GO:0005515	protein binding	7539425.16275648.25944354.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005737	cytoplasm	11585831.	IDA	Component
GO:0005739	mitochondrion	11585831.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006413	translational initiation	21873635.	IBA	Process
GO:0006415	translational termination	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016887	ATPase activity	-	IEA	Function
GO:0043024	ribosomal small subunit binding	21873635.	IBA	Function
GO:0051607	defense response to virus	-	TAS	Process
GO:0060338	regulation of type I interferon-mediated signaling pathway	-	TAS	Process
GO:0060698	endoribonuclease inhibitor activity	7539425.	IDA	Function
GO:0060702	negative regulation of endoribonuclease activity	7539425.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.