EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26464681	Low PBRM1 identifies tumor progression and poor prognosis in breast cancer.	Int J Clin Exp Pathol	2015 Aug 1	Mo D	-
25978027	PBRM1 suppresses bladder cancer by cyclin B1 induced cell cycle arrest.	Oncotarget	2015 Jun 30	Huang L	-
22949125	Loss of PBRM1 expression is associated with renal cell carcinoma progression.	Int J Cancer	2013 Jan 15	Pawowski R	doi: 10.1002/ijc.27822
12487023	cDNA cloning of the human polybromo-1 gene on chromosome 3p21.	DNA Seq	2002 Aug	Horikawa I	-
23644518	Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC.	Epigenetics	2013 May	Ibragimova I	doi: 10.4161/epi.24552
28082722	Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma.	Proc Natl Acad Sci U S A	2017 Jan 31	Gao W	doi: 10.1073/pnas.1619726114
29169846	PBRM1 and VHL expression correlate in human clear cell renal cell carcinoma with differential association with patient's overall survival.	Urol Oncol	2018 Mar	Hgner A	doi: 10.1016/j.urolonc.2017.10.027
30660076	Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.	Neoplasia	2019 Feb	Bihr S	doi: 10.1016/j.neo.2018.12.006
28940253	The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer.	J Pathol	2018 Jan	Shu XS	doi: 10.1002/path.4986
15735765	The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer.	Oncogene	2005 Apr 14	Sekine I	-
23867514	PBRM1 and BAP1 as novel targets for renal cell carcinoma.	Cancer J	2013 Jul-Aug	Brugarolas J	doi: 10.1097/PPO.0b013e3182a102d1.
21248752	Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.	Nature	2011 Jan 27	Varela I	doi: 10.1038/nature09639
28007623	Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).	J Thorac Oncol	2017 Apr	Augert A	doi: 10.1016/j.jtho.2016.12.011

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	52550578	Silent	novel	P1580P	0.56
ACC	chr3	52609635	Missense_Mutation	novel	A749S	0.14
BLCA	chr3	52609618	Frame_Shift_Del	NA	*V755Sfs20**	0.08
BLCA	chr3	52603587	Missense_Mutation	novel	E905Q	0.24
BLCA	chr3	52563443	Missense_Mutation	NA	I1309T	0.21
BLCA	chr3	52586369	Intron	novel		0.42
BLCA	chr3	52609545	Missense_Mutation	rs751804410	Q779E	0.46
BLCA	chr3	52662202	Silent	NA	Q153Q	0.12
BLCA	chr3	52586526	Missense_Mutation	novel	R1096C	0.45
BLCA	chr3	52564141	Missense_Mutation	NA	N1262D	0.56
BLCA	chr3	52662220	Silent	novel	T147T	0.61
BLCA	chr3	52548200	Nonsense_Mutation	novel	E1645*	0.34
BLCA	chr3	52554846	Missense_Mutation	novel	P1496L	0.17
BLCA	chr3	52658298	Missense_Mutation	NA	L182F	0.07
BLCA	chr3	52609344	Missense_Mutation	novel	E846K	0.07
BLCA	chr3	52563396	Missense_Mutation	NA	D1325N	0.42
BLCA	chr3	52561906	Missense_Mutation	novel	M1383I	0.11
BLCA	chr3	52548174	Silent	NA	L1653L	0.27
BLCA	chr3	52586667	Missense_Mutation	NA	E1049K	0.2
BLCA	chr3	52587511	Splice_Site	NA	X989_splice	0.15
BLCA	chr3	52634687	Missense_Mutation	novel	E406K	0.23
BLCA	chr3	52634789	Missense_Mutation	novel	E372Q	0.08
BLCA	chr3	52587353	Splice_Region	novel	K1041K	0.11
BLCA	chr3	52579193	Missense_Mutation	NA	E1132K	0.43
BLCA	chr3	52609581	Missense_Mutation	NA	E767Q	0.6
BLCA	chr3	52617333	Missense_Mutation	NA	E583K	0.35
BLCA	chr3	52564069	Missense_Mutation	novel	D1286N	0.41
BLCA	chr3	52550509	Frame_Shift_Ins	novel	*L1604Afs12**	0.27
BLCA	chr3	52550510	Frame_Shift_Ins	novel	*R1603Pfs14**	0.28
BLCA	chr3	52644791	Splice_Site	novel	X272_splice	0.41
BLCA	chr3	52561936	Missense_Mutation	novel	K1373N	0.13
BRCA	chr3	52634721	Missense_Mutation	NA	R394S	0.19
BRCA	chr3	52547895	3'Flank	novel		0.22
BRCA	chr3	52615442	Silent	novel	A611A	0.38
BRCA	chr3	52550767	Missense_Mutation	NA	G1554R	0.29
BRCA	chr3	52550810	Missense_Mutation	NA	M1539I	0.2
BRCA	chr3	52609663	Silent	NA	N739N	0.19
BRCA	chr3	52617322	Missense_Mutation	NA	M586I	0.31
BRCA	chr3	52679685	Silent	novel	T9T	0.06
BRCA	chr3	52547546	3'Flank	novel		0.17
BRCA	chr3	52554750	Frame_Shift_Ins	novel	*P1528Lfs88**	0.15
BRCA	chr3	52589127	Missense_Mutation	novel	E970Q	0.04
BRCA	chr3	52648383	Frame_Shift_Ins	novel	*N258Kfs6**	0.71
BRCA	chr3	52617499	Missense_Mutation	novel	F527L	0.11
CESC	chr3	52548210	Silent	rs138449080	S1641S	0.14
CESC	chr3	52579134	Silent	novel	L1151L	0.18
CESC	chr3	52662180	Missense_Mutation	rs769010138	D161H	0.38
CESC	chr3	52648367	Missense_Mutation	novel	E264K	0.53
CESC	chr3	52564072	Missense_Mutation	novel	D1285N	0.18
CESC	chr3	52634741	Nonsense_Mutation	NA	Q388*	0.23
CESC	chr3	52634775	Missense_Mutation	NA	I376M	0.26
CESC	chr3	52548225	Silent	rs758916169	R1636R	0.47
CESC	chr3	52617356	Missense_Mutation	NA	I575N	0.57
CESC	chr3	52546598	3'Flank	novel		0.62
CESC	chr3	52634665	Nonsense_Mutation	novel	S413*	0.45
CESC	chr3	52634759	Frame_Shift_Del	novel	*V382Ffs22**	0.29
CESC	chr3	52546053	3'Flank	novel		0.4
CHOL	chr3	52617318	Nonsense_Mutation	novel	E588*	0.24
CHOL	chr3	52627346	Nonsense_Mutation	novel	R490*	0.49
CHOL	chr3	52587422	In_Frame_Ins	novel	V1017_F1018insL	0.61
CHOL	chr3	52617480	Nonsense_Mutation	NA	R534*	0.12
CHOL	chr3	52678508	Frame_Shift_Del	novel	*R74Sfs18**	0.71
CHOL	chr3	52609643	Missense_Mutation	novel	Y746C	0.16
CHOL	chr3	52586633	In_Frame_Del	novel	D1055_E1060del	0.31
CHOL	chr3	52628923	Nonsense_Mutation	NA	R472*	0.28
CHOL	chr3	52644774	Nonsense_Mutation	NA	K277*	0.56
CHOL	chr3	52563283	Frame_Shift_Del	novel	*P1360Lfs21**	0.64
COAD	chr3	52587503	Frame_Shift_Del	NA	*K991Nfs23**	0.28
COAD	chr3	52609927	Frame_Shift_Del	NA	*K651Nfs5**	0.1
COAD	chr3	52644711	Nonsense_Mutation	NA	R298*	0.31
COAD	chr3	52679724	5'Flank	rs780698147		0.17
COAD	chr3	52563455	Missense_Mutation	NA	L1305Q	0.29
COAD	chr3	52586523	Missense_Mutation	rs143085435	V1097M	0.29
COAD	chr3	52609418	Missense_Mutation	NA	T821K	0.15
COAD	chr3	52658270	Missense_Mutation	NA	A192T	0.05
COAD	chr3	52678564	Nonsense_Mutation	NA	R58*	0.43
COAD	chr3	52609501	Missense_Mutation	NA	Q793H	0.06
COAD	chr3	52603673	Missense_Mutation	NA	R876H	0.3
COAD	chr3	52644774	Nonsense_Mutation	NA	K277*	0.47
COAD	chr3	52563324	Frame_Shift_Del	NA	*L1349Wfs35**	0.5
COAD	chr3	52548222	Silent	rs527392994	D1637D	0.3
COAD	chr3	52576673	Missense_Mutation	NA	G1187R	0.32
COAD	chr3	52644768	Frame_Shift_Del	rs771618422	*I279Yfs4**	0.34
COAD	chr3	52617354	Missense_Mutation	novel	R576C	0.13
COAD	chr3	52576590	Silent	NA	E1214E	0.11
COAD	chr3	52589171	Frame_Shift_Del	NA	*N955Tfs59**	0.28
COAD	chr3	52678586	Silent	NA	C50C	0.08
COAD	chr3	52609374	Missense_Mutation	NA	R836W	0.27
COAD	chr3	52617380	Missense_Mutation	NA	D567V	0.33
COAD	chr3	52554771	Frame_Shift_Ins	NA	*H1521Pfs95**	0.12
COAD	chr3	52628985	Missense_Mutation	NA	D451G	0.13
COAD	chr3	52617390	Nonsense_Mutation	NA	E564*	0.36
COAD	chr3	52587442	Missense_Mutation	novel	F1012V	0.13
COAD	chr3	52603674	Missense_Mutation	novel	R876C	0.17
COAD	chr3	52617318	Nonsense_Mutation	novel	E588*	0.14
COAD	chr3	52576541	Missense_Mutation	NA	G1231R	0.38
COAD	chr3	52564094	Missense_Mutation	NA	F1277L	0.1
COAD	chr3	52589171	Frame_Shift_Del	NA	*N955Tfs59**	0.35
COAD	chr3	52609927	Frame_Shift_Del	NA	*K651Nfs5**	0.3
DLBC	chr3	52678575	Missense_Mutation	novel	Y54C	0.59
ESCA	chr3	52644768	Frame_Shift_Del	rs771618422	*I279Yfs4**	0.25
ESCA	chr3	52617322	Missense_Mutation	novel	M586I	0.49
ESCA	chr3	52603672	Frame_Shift_Del	novel	*D877Mfs38**	0.19
ESCA	chr3	52603674	In_Frame_Del	novel	F872_R876delinsC	0.17
ESCA	chr3	52678564	Nonsense_Mutation	NA	R58*	0.26
ESCA	chr3	52547752	3'Flank	novel		0.15
ESCA	chr3	52547753	3'Flank	novel		0.14
ESCA	chr3	52628961	Missense_Mutation	novel	A459V	0.43
ESCA	chr3	52617516	Nonsense_Mutation	novel	R522*	0.71
GBM	chr3	52609873	Silent	novel	V669V	0.15
GBM	chr3	52586284	Intron	novel		0.19
GBM	chr3	52609752	Nonsense_Mutation	NA	R710*	0.06
GBM	chr3	52603674	Missense_Mutation	novel	R876S	0.12
GBM	chr3	52561824	Missense_Mutation	NA	R1411C	0.16
HNSC	chr3	52576689	Splice_Site	novel	X1178_splice	0.33
HNSC	chr3	52617497	Missense_Mutation	NA	N528I	0.39
HNSC	chr3	52609844	Missense_Mutation	rs763078803	R679H	0.12
HNSC	chr3	52668569	Missense_Mutation	novel	E105Q	0.19
HNSC	chr3	52617266	Missense_Mutation	NA	S605F	0.46
HNSC	chr3	52627270	Splice_Region	novel		0.22
HNSC	chr3	52603559	Frame_Shift_Ins	novel	*I914Rfs6**	0.13
HNSC	chr3	52678534	Missense_Mutation	novel	L68F	0.24
HNSC	chr3	52642045	Splice_Region	novel	R332R	0.07
HNSC	chr3	52603642	Silent	novel	L886L	0.23
HNSC	chr3	52589213	Nonsense_Mutation	NA	S941*	0.1
HNSC	chr3	52641975	Nonsense_Mutation	novel	E356*	0.28
HNSC	chr3	52642013	Missense_Mutation	novel	S343L	0.21
HNSC	chr3	52609601	Missense_Mutation	rs199976998	R760H	0.13
KICH	chr3	52609584	Missense_Mutation	novel	D766Y	0.04
KIRC	chr3	52668553	Frame_Shift_Del	NA	*N110Ifs3**	0.45
KIRC	chr3	52617333	Frame_Shift_Del	NA	*G582Rfs18**	0.35
KIRC	chr3	52627361	Nonsense_Mutation	NA	K485*	0.28
KIRC	chr3	52658220	Frame_Shift_Del	novel	*Q209Rfs15**	0.5
KIRC	chr3	52662148	Frame_Shift_Del	novel	*T172Qfs2**	0.26
KIRC	chr3	52609344	Nonsense_Mutation	NA	E846*	0.39
KIRC	chr3	52609545	Nonsense_Mutation	NA	Q779*	0.35
KIRC	chr3	52609352	Frame_Shift_Del	NA	*R836Lfs12**	0.26
KIRC	chr3	52586595	Frame_Shift_Del	NA	*I1073Lfs86**	0.27
KIRC	chr3	52644790	Splice_Site	NA	X272_splice	0.1
KIRC	chr3	52609332	Nonsense_Mutation	NA	R850*	0.14
KIRC	chr3	52658282	Nonsense_Mutation	NA	Q188*	0.39
KIRC	chr3	52629036	Splice_Site	NA	X434_splice	0.11
KIRC	chr3	52579107	Frame_Shift_Del	NA	*G1161Afs57**	0.31
KIRC	chr3	52678598	Splice_Site	novel	X47_splice	0.52
KIRC	chr3	52644718	Frame_Shift_Del	novel	*M292Ifs5**	0.14
KIRC	chr3	52678595	Splice_Site	novel	X47_splice	0.41
KIRC	chr3	52609752	Nonsense_Mutation	NA	R710*	0.27
KIRC	chr3	52609517	Nonsense_Mutation	NA	S788*	0.21
KIRC	chr3	52563332	Frame_Shift_Del	novel	*Q1346Rfs38**	0.15
KIRC	chr3	52617277	Missense_Mutation	NA	N601K	0.25
KIRC	chr3	52615422	Missense_Mutation	NA	L618H	0.57
KIRC	chr3	52617320	Missense_Mutation	NA	I587T	0.52
KIRC	chr3	52586346	Intron	NA		0.58
KIRC	chr3	52643249	Frame_Shift_Del	NA	*R332Vfs30**	0.62
KIRC	chr3	52651740	Splice_Site	novel	X238_splice	0.3
KIRC	chr3	52561771	Nonsense_Mutation	NA	Y1428*	0.22
KIRC	chr3	52576643	Frame_Shift_Del	novel	*I1197Ffs21**	0.4
KIRC	chr3	52548200	Nonsense_Mutation	novel	E1645*	0.06
KIRC	chr3	52579183	Frame_Shift_Del	novel	*P1135Lfs24**	0.12
KIRC	chr3	52644748	Frame_Shift_Del	novel	*K283Rfs3**	0.16
KIRC	chr3	52662132	Splice_Site	NA	X176_splice	0.29
KIRC	chr3	52587448	Nonsense_Mutation	NA	R1010*	0.19
KIRC	chr3	52603695	Nonsense_Mutation	NA	Q869*	0.47
KIRC	chr3	52662236	Frame_Shift_Ins	novel	*D142Gfs9**	0.33
KIRC	chr3	52609725	Nonsense_Mutation	NA	Q719*	0.61
KIRC	chr3	52587503	Frame_Shift_Del	NA	*K991Nfs23**	0.4
KIRC	chr3	52563477	Nonsense_Mutation	NA	Q1298*	0.37
KIRC	chr3	52561847	Frame_Shift_Del	NA	*D1403Lfs18**	0.2
KIRC	chr3	52576627	Missense_Mutation	NA	T1202K	0.36
KIRC	chr3	52628896	Nonsense_Mutation	NA	Q481*	0.64
KIRC	chr3	52609882	Nonsense_Mutation	NA	Y666*	0.36
KIRC	chr3	52603695	Frame_Shift_Ins	novel	*Q869Sfs6**	0.26
KIRC	chr3	52679587	Missense_Mutation	NA	P42L	0.27
KIRC	chr3	52548124	Missense_Mutation	NA	R1670P	0.15
KIRC	chr3	52579193	Nonsense_Mutation	NA	E1132*	0.34
KIRC	chr3	52609752	Nonsense_Mutation	NA	R710*	0.41
KIRC	chr3	52668501	Frame_Shift_Del	novel	*N122Kfs47**	0.2
KIRC	chr3	52609812	Nonsense_Mutation	NA	R690*	0.48
KIRC	chr3	52587502	Frame_Shift_Ins	novel	*W992Mfs12**	0.27
KIRC	chr3	52586432	Frame_Shift_Del	novel	*N1126Gfs15**	0.24
KIRC	chr3	52586658	Nonsense_Mutation	NA	R1052*	0.1
KIRC	chr3	52576592	Frame_Shift_Ins	NA	*E1214Rfs6**	0.35
KIRC	chr3	52587430	Nonsense_Mutation	NA	E1016*	0.2
KIRC	chr3	52564047	Splice_Region	novel		0.16
KIRC	chr3	52550499	Frame_Shift_Del	novel	*S1607Qfs5**	0.34
KIRC	chr3	52615424	Frame_Shift_Del	novel	*L617Ffs25**	0.47
KIRC	chr3	52617341	Missense_Mutation	NA	Y580C	0.36
KIRC	chr3	52587417	Frame_Shift_Del	NA	S1020*	0.51
KIRC	chr3	52662183	Frame_Shift_Del	novel	*E160Kfs14**	0.68
KIRC	chr3	52678564	Nonsense_Mutation	NA	R58*	0.42
KIRC	chr3	52603539	Nonsense_Mutation	NA	R921*	0.24
KIRC	chr3	52609727	Missense_Mutation	NA	Y718C	0.44
KIRC	chr3	52634639	Nonsense_Mutation	NA	Q422*	0.23
KIRC	chr3	52586501	Frame_Shift_Ins	novel	*A1104Gfs3**	0.37
KIRC	chr3	52648443	Splice_Site	NA	X239_splice	0.33
KIRC	chr3	52627309	Nonsense_Mutation	NA	S502*	0.84
KIRC	chr3	52644767	Frame_Shift_Ins	novel	*I279Nfs8**	0.35
KIRC	chr3	52609892	Frame_Shift_Del	novel	*N663Mfs7**	0.47
KIRC	chr3	52615357	Nonsense_Mutation	NA	K640*	0.24
KIRC	chr3	52642047	Splice_Site	novel	X332_splice	0.48
KIRC	chr3	52658219	Nonsense_Mutation	NA	Q209*	0.52
KIRC	chr3	52615361	Frame_Shift_Del	NA	*K638Nfs4**	0.35
KIRC	chr3	52564142	Nonsense_Mutation	NA	Y1261*	0.47
KIRC	chr3	52668522	Frame_Shift_Del	novel	F120*	0.19
KIRC	chr3	52564064	Missense_Mutation	NA	E1287D	0.58
KIRC	chr3	52679583	Frame_Shift_Ins	novel	*V44Cfs9**	0.57
KIRC	chr3	52609385	Frame_Shift_Del	NA	*N832Ifs23**	0.36
KIRC	chr3	52628895	Frame_Shift_Del	NA	*Q481Rfs19**	0.46
KIRC	chr3	52589094	Nonsense_Mutation	NA	E981*	0.39
KIRC	chr3	52658198	Splice_Site	novel	X215_splice	0.29
KIRC	chr3	52603676	In_Frame_Del	NA	K874_I875delinsN	0.27
KIRC	chr3	52563324	Frame_Shift_Del	NA	*L1349Wfs35**	0.38
KIRC	chr3	52617360	Missense_Mutation	novel	N574Y	0.52
KIRC	chr3	52662261	Frame_Shift_Ins	novel	*Y134Ifs2**	0.34
KIRC	chr3	52561806	Missense_Mutation	NA	W1417G	0.28
KIRC	chr3	52561813	Frame_Shift_Del	NA	*T1415Qfs66**	0.27
KIRC	chr3	52550749	Frame_Shift_Ins	novel	*Q1560Nfs37**	0.46
KIRC	chr3	52658263	Frame_Shift_Del	NA	*V194Cfs11**	0.23
KIRC	chr3	52617531	Frame_Shift_Del	novel	*N517Hfs15**	0.6
KIRC	chr3	52587496	Frame_Shift_Del	NA	*L993Mfs20**	0.61
KIRC	chr3	52668596	Nonsense_Mutation	NA	K96*	0.38
KIRC	chr3	52678589	Frame_Shift_Del	novel	*C50Afs45**	0.7
KIRC	chr3	52634650	Frame_Shift_Del	novel	*G401Vfs20**	0.17
KIRC	chr3	52576568	Frame_Shift_Del	novel	*E1222Kfs5**	0.46
KIRC	chr3	52554802	Frame_Shift_Del	novel	*Q1511Sfs28**	0.49
KIRC	chr3	52554823	Frame_Shift_Del	NA	*V1505Lfs34**	0.32
KIRC	chr3	52554732	Frame_Shift_Del	NA	*P1534Hfs5**	0.44
KIRC	chr3	52644761	Frame_Shift_Del	NA	*Y281Lfs2**	0.19
KIRC	chr3	52564222	Frame_Shift_Del	NA	*V1235Cfs34**	0.23
KIRC	chr3	52563363	Frame_Shift_Del	novel	*V1336Sfs48**	0.44
KIRC	chr3	52603643	Missense_Mutation	novel	L886R	0.18
KIRC	chr3	52643269	Frame_Shift_Del	novel	*N325Ifs37**	0.22
KIRC	chr3	52603672	Frame_Shift_Del	novel	Y862*	0.5
KIRC	chr3	52678585	In_Frame_Ins	novel	C50_H51insKHFNT	0.07
KIRC	chr3	52678587	Missense_Mutation	novel	C50S	0.02
KIRC	chr3	52679592	Frame_Shift_Del	NA	*S39Ffs4**	0.35
KIRC	chr3	52648430	Nonsense_Mutation	NA	K243*	0.37
KIRC	chr3	52617323	Missense_Mutation	NA	M586T	0.55
KIRC	chr3	52554861	Frame_Shift_Del	NA	*P1491Rfs48**	0.62
KIRC	chr3	52589105	Frame_Shift_Del	NA	*I977Rfs4**	0.47
KIRC	chr3	52668533	Frame_Shift_Del	novel	*D115Sfs57**	0.28
KIRC	chr3	52648430	Splice_Site	novel	X239_splice	0.38
KIRC	chr3	52550818	Splice_Site	NA	X1537_splice	0.28
KIRC	chr3	52609638	Frame_Shift_Del	NA	*D748Mfs27**	0.38
KIRC	chr3	52634654	Frame_Shift_Ins	NA	*Y417Ifs3**	0.4
KIRC	chr3	52617283	Frame_Shift_Del	NA	*Y600Ifs42**	0.42
KIRC	chr3	52563353	Frame_Shift_Del	novel	*P1339Lfs45**	0.24
KIRC	chr3	52678553	Frame_Shift_Del	novel	*D59Mfs33**	0.19
KIRC	chr3	52563490	Frame_Shift_Del	novel	*K1293Nfs20**	0.2
KIRC	chr3	52589101	Silent	NA	V978V	0.31
KIRC	chr3	52617367	Frame_Shift_Del	novel	*I571Mfs16**	0.4
KIRC	chr3	52617323	Missense_Mutation	NA	M586K	0.36
KIRC	chr3	52615435	Missense_Mutation	NA	L614V	0.53
KIRC	chr3	52548074	Frame_Shift_Del	novel	*E1687Kfs?**	0.49
KIRC	chr3	52662183	Nonsense_Mutation	NA	E160*	0.6
KIRC	chr3	52589246	Frame_Shift_Del	NA	*K930Rfs84**	0.45
KIRC	chr3	52589251	Silent	NA	A928A	0.44
KIRC	chr3	52586669	Missense_Mutation	NA	P1048R	0.41
KIRC	chr3	52662153	Nonsense_Mutation	NA	Q170*	0.31
KIRC	chr3	52609782	Frame_Shift_Del	novel	Y697*	0.43
KIRC	chr3	52609638	Frame_Shift_Del	NA	*D748Mfs27**	0.35
KIRC	chr3	52609754	Missense_Mutation	NA	I709T	0.53
KIRC	chr3	52550536	Frame_Shift_Del	novel	*F1594Lfs2**	0.68
KIRC	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.18
KIRC	chr3	52644729	Frame_Shift_Del	novel	*E291Dfs3**	0.31
KIRC	chr3	52628994	Frame_Shift_Del	novel	*L448Wfs5**	0.32
KIRC	chr3	52587363	Frame_Shift_Del	novel	*M1038Sfs121**	0.03
KIRC	chr3	52658317	Splice_Site	NA	X177_splice	0.27
KIRC	chr3	52550627	Frame_Shift_Del	novel	*L1564Wfs32**	0.68
KIRC	chr3	52576569	Frame_Shift_Del	novel	*E1222Kfs5**	0.56
KIRC	chr3	52629019	Nonsense_Mutation	NA	Q440*	0.29
KIRC	chr3	52603573	Frame_Shift_Del	novel	*K909Nfs6**	0.29
KIRC	chr3	52617403	Nonsense_Mutation	NA	Y559*	0.33
KIRC	chr3	52634801	Nonsense_Mutation	NA	E368*	0.33
KIRC	chr3	52564226	Missense_Mutation	NA	C1233W	0.38
KIRC	chr3	52576585	Frame_Shift_Ins	novel	*F1216Yfs3**	0.2
KIRC	chr3	52634678	Frame_Shift_Del	novel	*Y409Tfs29**	0.46
KIRC	chr3	52576699	Splice_Site	NA	X1178_splice	0.41
KIRC	chr3	52617366	Frame_Shift_Ins	novel	E572*	0.4
KIRC	chr3	52628968	Nonsense_Mutation	NA	E457*	0.41
KIRC	chr3	52609332	Nonsense_Mutation	NA	R850*	0.09
KIRP	chr3	52564049	Splice_Site	NA	X1292_splice	0.3
KIRP	chr3	52609752	Nonsense_Mutation	NA	R710*	0.62
KIRP	chr3	52627322	Frame_Shift_Del	novel	*S498Afs2**	0.45
KIRP	chr3	52617539	Splice_Site	NA	X514_splice	0.68
KIRP	chr3	52644767	Frame_Shift_Ins	novel	*I279Nfs8**	0.83
KIRP	chr3	52554775	Missense_Mutation	NA	P1520T	0.49
KIRP	chr3	52643251	Missense_Mutation	rs747444363	Y331C	0.34
KIRP	chr3	52615414	Nonsense_Mutation	NA	K621*	0.56
KIRP	chr3	52550593	Nonsense_Mutation	NA	Y1575*	0.73
KIRP	chr3	52662256	Frame_Shift_Del	novel	*A136Pfs38**	0.65
KIRP	chr3	52603631	Missense_Mutation	NA	A890E	0.87
KIRP	chr3	52579168	Frame_Shift_Del	NA	*N1140Mfs19**	0.75
KIRP	chr3	52563421	Frame_Shift_Del	novel	*F1316Lfs4**	0.81
LAML	chr3	52648408	Missense_Mutation	novel	K250R	0.1
LGG	chr3	52561928	Frame_Shift_Del	novel	*G1376Afs8**	0.46
LGG	chr3	52563289	Silent	NA	P1360P	0.06
LGG	chr3	52576650	Frame_Shift_Del	novel	*I1195Sfs23**	0.49
LGG	chr3	52564147	Missense_Mutation	novel	R1260C	0.37
LGG	chr3	52603539	Nonsense_Mutation	NA	R921*	0.46
LGG	chr3	52609900	Missense_Mutation	novel	Q660H	0.28
LGG	chr3	52634743	Frame_Shift_Ins	novel	*Y387Lfs5**	0.53
LGG	chr3	52644765	Missense_Mutation	novel	F280V	0.46
LGG	chr3	52609516	Silent	NA	S788S	0.08
LGG	chr3	52564201	Frame_Shift_Del	novel	*L1242Sfs27**	0.06
LGG	chr3	52617414	Missense_Mutation	NA	P556S	0.37
LGG	chr3	52587356	Silent	NA	V1040V	0.43
LIHC	chr3	52564066	Missense_Mutation	NA	E1287K	0.7
LIHC	chr3	52561926	Missense_Mutation	novel	S1377A	0.38
LIHC	chr3	52628923	Nonsense_Mutation	NA	R472*	0.06
LIHC	chr3	52550490	Missense_Mutation	NA	Y1610H	0.78
LIHC	chr3	52564185	Missense_Mutation	NA	T1247I	0.43
LIHC	chr3	52634654	Frame_Shift_Ins	NA	*Y417Ifs3**	0.79
LIHC	chr3	52628923	Nonsense_Mutation	NA	R472*	0.59
LUAD	chr3	52548057	3'UTR	novel		0.18
LUAD	chr3	52609664	Missense_Mutation	NA	N739S	0.27
LUAD	chr3	52615407	Missense_Mutation	NA	K623R	0.25
LUAD	chr3	52550582	Missense_Mutation	novel	H1579L	0.06
LUAD	chr3	52550589	Missense_Mutation	NA	G1577C	0.23
LUAD	chr3	52589213	Nonsense_Mutation	NA	S941*	0.4
LUAD	chr3	52589213	Nonsense_Mutation	NA	S941*	0.41
LUAD	chr3	52550746	Splice_Site	NA	X1560_splice	0.43
LUAD	chr3	52589094	Missense_Mutation	novel	E981Q	0.06
LUAD	chr3	52609255	Splice_Site	novel	X841_splice	0.28
LUAD	chr3	52679703	Silent	NA	S3S	0.14
LUAD	chr3	52634599	Splice_Region	novel		0.68
LUAD	chr3	52617515	Missense_Mutation	NA	R522L	0.33
LUAD	chr3	52563374	Frame_Shift_Ins	novel	*E1332Gfs3**	0.12
LUAD	chr3	52609688	Missense_Mutation	NA	M731K	0.06
LUAD	chr3	52586302	Intron	novel		0.07
LUSC	chr3	52589167	Missense_Mutation	novel	S956R	0.33
LUSC	chr3	52563287	Frame_Shift_Del	novel	*P1361Hfs23**	0.3
LUSC	chr3	52609761	Nonsense_Mutation	novel	E707*	0.3
LUSC	chr3	52548224	Missense_Mutation	rs201397730	D1637N	0.05
LUSC	chr3	52548225	Silent	rs758916169	R1636R	0.07
LUSC	chr3	52609733	Missense_Mutation	novel	N716T	0.05
LUSC	chr3	52586295	Intron	novel		0.16
LUSC	chr3	52589069	Splice_Site	NA	X989_splice	0.37
LUSC	chr3	52628970	Missense_Mutation	NA	F456S	0.3
LUSC	chr3	52658292	Missense_Mutation	NA	E184D	0.1
LUSC	chr3	52587511	Splice_Site	NA	X989_splice	0.55
LUSC	chr3	52651780	Missense_Mutation	NA	E226Q	0.51
LUSC	chr3	52609413	Missense_Mutation	NA	D823H	0.33
LUSC	chr3	52587502	Frame_Shift_Ins	novel	*W992Mfs12**	0.47
LUSC	chr3	52576547	Missense_Mutation	novel	I1229V	0.28
LUSC	chr3	52648424	Missense_Mutation	NA	I245F	0.21
LUSC	chr3	52617298	Silent	NA	F594F	0.14
LUSC	chr3	52648384	Frame_Shift_Del	NA	*N258Mfs25**	0.67
MESO	chr3	52587463	In_Frame_Del	novel	Y999_T1004del	0.26
MESO	chr3	52634639	Nonsense_Mutation	NA	Q422*	0.5
MESO	chr3	52550633	Frame_Shift_Del	novel	*G1562Efs34**	0.43
OV	chr3	52589146	Nonsense_Mutation	NA	Y963*	0.19
OV	chr3	52651811	Splice_Site	novel	X216_splice	0.08
OV	chr3	52579114	Frame_Shift_Ins	novel	*L1158Qfs12**	0.03
OV	chr3	52658196	Splice_Site	novel	X207_splice	0.1
PAAD	chr3	52603519	Splice_Site	novel	X927_splice	0.05
PAAD	chr3	52586526	Missense_Mutation	novel	R1096C	0.21
PAAD	chr3	52603674	Missense_Mutation	novel	R876C	0.15
PAAD	chr3	52564105	Missense_Mutation	novel	L1274V	0.22
PAAD	chr3	52617461	Missense_Mutation	NA	R540T	0.03
PAAD	chr3	52615457	Splice_Site	NA	X607_splice	0.08
PAAD	chr3	52576699	Splice_Site	novel	X1178_splice	0.03
PRAD	chr3	52564055	Silent	novel	Y1290Y	0.45
PRAD	chr3	52648401	Silent	novel	I252I	0.07
PRAD	chr3	52662207	Missense_Mutation	novel	V152F	0.05
PRAD	chr3	52586348	Intron	novel		0.39
PRAD	chr3	52634623	Missense_Mutation	novel	P427L	0.4
PRAD	chr3	52679663	Missense_Mutation	rs764436452	G17R	0.2
READ	chr3	52609383	Missense_Mutation	rs146395938	R833C	0.32
READ	chr3	52548161	Missense_Mutation	novel	A1658S	0.15
READ	chr3	52563417	Missense_Mutation	rs199643728	E1318K	0.64
READ	chr3	52548046	3'UTR	novel		0.37
READ	chr3	52668585	Silent	novel	Q99Q	0.42
READ	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.15
READ	chr3	52603674	Missense_Mutation	novel	R876C	0.31
READ	chr3	52628956	Missense_Mutation	rs779427834	R461C	0.28
READ	chr3	52634661	Missense_Mutation	NA	K414N	0.42
SARC	chr3	52609653	Missense_Mutation	novel	S743T	0.44
SARC	chr3	52561893	Silent	NA	L1388L	0.27
SARC	chr3	52589090	Missense_Mutation	NA	R982K	0.3
SARC	chr3	52547695	3'Flank	novel		0.83
SARC	chr3	52662183	Missense_Mutation	rs774655494	E160K	0.47
SARC	chr3	52644768	Frame_Shift_Del	rs771618422	*I279Yfs4**	0.21
SKCM	chr3	52576559	Missense_Mutation	novel	P1225S	0.2
SKCM	chr3	52609731	Nonsense_Mutation	NA	K717*	0.31
SKCM	chr3	52615457	Splice_Site	NA	X607_splice	0.18
SKCM	chr3	52658309	Missense_Mutation	novel	P179S	0.39
SKCM	chr3	52576681	Missense_Mutation	novel	V1184A	0.37
SKCM	chr3	52634668	Missense_Mutation	novel	P412L	0.16
SKCM	chr3	52603674	Missense_Mutation	novel	R876C	0.29
SKCM	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.93
SKCM	chr3	52564117	Missense_Mutation	NA	K1270Q	0.46
SKCM	chr3	52576684	Nonsense_Mutation	NA	W1183*	0.42
SKCM	chr3	52586554	Silent	rs773918156	V1086V	0.28
SKCM	chr3	52589149	Silent	NA	D962D	0.05
SKCM	chr3	52609775	Missense_Mutation	NA	K702T	0.1
SKCM	chr3	52561877	Frame_Shift_Del	novel	*S1391Efs5**	0.7
SKCM	chr3	52563472	Silent	NA	K1299K	0.45
SKCM	chr3	52634769	Silent	NA	S378S	0.32
SKCM	chr3	52550427	Silent	NA	L1631L	0.39
SKCM	chr3	52609858	Silent	novel	D674D	0.12
SKCM	chr3	52617497	Missense_Mutation	rs201580633	N528S	0.13
SKCM	chr3	52586627	Missense_Mutation	rs757754297	R1062Q	0.44
SKCM	chr3	52579133	Missense_Mutation	novel	H1152Y	0.26
SKCM	chr3	52609752	Nonsense_Mutation	NA	R710*	0.73
SKCM	chr3	52643306	Missense_Mutation	NA	P313S	0.6
SKCM	chr3	52576592	Frame_Shift_Ins	NA	*E1214Rfs6**	0.21
SKCM	chr3	52641959	Nonsense_Mutation	NA	L361*	0.2
SKCM	chr3	52548119	Missense_Mutation	NA	L1672M	0.84
SKCM	chr3	52668627	Nonsense_Mutation	NA	Y85*	0.77
SKCM	chr3	52662164	Missense_Mutation	novel	G166E	0.49
SKCM	chr3	52586623	Nonsense_Mutation	NA	Y1063*	0.4
SKCM	chr3	52609469	Nonsense_Mutation	NA	L804*	0.36
SKCM	chr3	52586526	Missense_Mutation	novel	R1096C	0.42
STAD	chr3	52587477	Missense_Mutation	rs750583919	R1000Q	0.29
STAD	chr3	52586353	Intron	novel		0.12
STAD	chr3	52648383	Frame_Shift_Ins	novel	*N258Kfs6**	0.2
STAD	chr3	52554782	Frame_Shift_Del	NA	*P1518Lfs21**	0.18
STAD	chr3	52609926	Frame_Shift_Ins	novel	*S652Ifs13**	0.24
STAD	chr3	52644768	Frame_Shift_Del	rs771618422	*I279Yfs4**	0.56
STAD	chr3	52609709	Missense_Mutation	novel	M724T	0.27
STAD	chr3	52576538	Splice_Region	novel		0.18
STAD	chr3	52576607	Frame_Shift_Del	novel	*M1209Cfs9**	0.17
STAD	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.43
STAD	chr3	52617297	Missense_Mutation	rs777012889	R595W	0.3
STAD	chr3	52561920	Missense_Mutation	NA	R1379W	0.07
STAD	chr3	52617422	Frame_Shift_Del	NA	*K553Rfs16**	0.31
STAD	chr3	52648373	Frame_Shift_Del	novel	Y262*	0.29
STAD	chr3	52658269	Missense_Mutation	novel	A192V	0.43
STAD	chr3	52564056	Missense_Mutation	NA	Y1290F	0.08
STAD	chr3	52609724	Missense_Mutation	NA	Q719R	0.11
STAD	chr3	52586395	Intron	novel		0.44
STAD	chr3	52648383	Frame_Shift_Ins	novel	*N258Kfs6**	0.42
STAD	chr3	52634670	Silent	novel	L411L	0.1
STAD	chr3	52550805	Frame_Shift_Del	novel	*M1539Kfs7**	0.09
STAD	chr3	52589103	Missense_Mutation	rs375687372	V978I	0.06
STAD	chr3	52586661	Missense_Mutation	NA	F1051V	0.26
STAD	chr3	52586651	Missense_Mutation	NA	E1054V	0.11
STAD	chr3	52644768	Frame_Shift_Del	rs771618422	*I279Yfs4**	0.44
STAD	chr3	52609755	Frame_Shift_Del	NA	*I709Ffs5**	0.31
STAD	chr3	52589145	Missense_Mutation	rs756858926	V964I	0.23
STAD	chr3	52617353	Missense_Mutation	rs554214396	R576H	0.32
STAD	chr3	52579201	Splice_Site	NA	X1130_splice	0.15
STAD	chr3	52678504	Nonsense_Mutation	NA	R78*	0.32
STAD	chr3	52678554	Missense_Mutation	NA	K61T	0.3
STAD	chr3	52617422	Frame_Shift_Del	NA	*K553Rfs16**	0.07
STAD	chr3	52563324	Frame_Shift_Del	NA	*L1349Wfs35**	0.2
STAD	chr3	52586524	Silent	rs751247753	R1096R	0.31
STAD	chr3	52561927	Silent	NA	G1376G	0.21
STAD	chr3	52603731	Missense_Mutation	NA	T857A	0.17
STAD	chr3	52609774	Frame_Shift_Ins	novel	*P703Afs20**	0.19
STAD	chr3	52609926	Frame_Shift_Ins	novel	*S652Ifs13**	0.23
STAD	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.25
STAD	chr3	52648384	Frame_Shift_Del	NA	*N258Mfs25**	0.1
STAD	chr3	52603684	Frame_Shift_Del	novel	*F872Lfs43**	0.67
TGCT	chr3	52634654	Frame_Shift_Ins	NA	*Y417Ifs3**	0.35
THYM	chr3	52586435	Missense_Mutation	novel	N1126S	0.08
THYM	chr3	52662250	Silent	novel	A137A	0.11
THYM	chr3	52603573	Frame_Shift_Del	novel	*K909Nfs6**	0.47
UCEC	chr3	52586239	Intron	novel		0.36
UCEC	chr3	52627271	Splice_Site	novel	X514_splice	0.28
UCEC	chr3	52561898	Missense_Mutation	novel	Y1386C	0.18
UCEC	chr3	52563351	Missense_Mutation	novel	P1340S	0.13
UCEC	chr3	52589185	Silent	novel	D950D	0.21
UCEC	chr3	52546309	3'Flank	novel		0.31
UCEC	chr3	52547073	3'Flank	novel		0.32
UCEC	chr3	52579063	Missense_Mutation	novel	R1175H	0.55
UCEC	chr3	52648373	Missense_Mutation	novel	Y262H	0.39
UCEC	chr3	52617380	Missense_Mutation	novel	D567G	0.16
UCEC	chr3	52678563	Missense_Mutation	novel	R58Q	0.32
UCEC	chr3	52546692	3'Flank	novel		0.53
UCEC	chr3	52546225	3'Flank	novel		0.17
UCEC	chr3	52576544	Missense_Mutation	novel	L1230I	0.13
UCEC	chr3	52644779	Nonsense_Mutation	NA	S275*	0.2
UCEC	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.28
UCEC	chr3	52648383	Frame_Shift_Ins	novel	*N258Kfs6**	0.38
UCEC	chr3	52603539	Nonsense_Mutation	NA	R921*	0.4
UCEC	chr3	52547920	3'Flank	rs148181025		0.29
UCEC	chr3	52609314	Missense_Mutation	novel	R856W	0.1
UCEC	chr3	52547920	3'Flank	rs148181025		0.13
UCEC	chr3	52668646	Splice_Site	novel	X79_splice	0.24
UCEC	chr3	52547695	3'Flank	novel		0.63
UCEC	chr3	52550589	Missense_Mutation	rs200150658	G1577S	0.35
UCEC	chr3	52561920	Missense_Mutation	NA	R1379W	0.06
UCEC	chr3	52545961	3'Flank	novel		0.3
UCEC	chr3	52547393	3'Flank	novel		0.23
UCEC	chr3	52547812	3'Flank	novel		0.38
UCEC	chr3	52609752	Nonsense_Mutation	NA	R710*	0.48
UCEC	chr3	52546188	3'Flank	novel		0.52
UCEC	chr3	52547497	3'Flank	novel		0.45
UCEC	chr3	52546085	3'Flank	novel		0.25
UCEC	chr3	52644768	Frame_Shift_Del	rs771618422	*I279Yfs4**	0.53
UCEC	chr3	52658257	Nonsense_Mutation	novel	*A196Gfs5**	0.13
UCEC	chr3	52546252	3'Flank	novel		0.4
UCEC	chr3	52564133	Silent	rs747158451	S1264S	0.31
UCEC	chr3	52589146	Silent	novel	Y963Y	0.43
UCEC	chr3	52617516	Nonsense_Mutation	novel	R522*	0.47
UCEC	chr3	52564136	Missense_Mutation	novel	E1263D	0.12
UCEC	chr3	52587376	Nonsense_Mutation	NA	K1034*	0.34
UCEC	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.2
UCEC	chr3	52550797	Missense_Mutation	novel	A1544T	0.45
UCEC	chr3	52579104	Silent	rs779151140	G1161G	0.4
UCEC	chr3	52609472	Missense_Mutation	novel	S803Y	0.4
UCEC	chr3	52651776	Missense_Mutation	novel	P227H	0.42
UCEC	chr3	52603730	Missense_Mutation	novel	T857I	0.27
UCEC	chr3	52546261	3'Flank	novel		0.38
UCEC	chr3	52576544	Missense_Mutation	novel	L1230I	0.37
UCEC	chr3	52579066	Missense_Mutation	novel	P1174L	0.52
UCEC	chr3	52634654	Missense_Mutation	novel	Y417H	0.49
UCEC	chr3	52662244	Silent	novel	K139K	0.53
UCEC	chr3	52679613	Silent	novel	R33R	0.44
UCEC	chr3	52609752	Nonsense_Mutation	NA	R710*	0.09
UCEC	chr3	52609937	Missense_Mutation	novel	S648Y	0.4
UCEC	chr3	52609419	Missense_Mutation	NA	T821A	0.43
UCEC	chr3	52679653	Missense_Mutation	NA	D20G	0.32
UCEC	chr3	52634654	Frame_Shift_Ins	NA	*Y417Ifs3**	0.29
UCEC	chr3	52548091	Missense_Mutation	rs371624499	R1681H	0.33
UCEC	chr3	52668587	Nonsense_Mutation	novel	Q99*	0.38
UCEC	chr3	52617454	Silent	novel	L542L	0.13
UCEC	chr3	52546382	3'Flank	novel		0.47
UCEC	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.51
UCEC	chr3	52628923	Nonsense_Mutation	NA	R472*	0.49
UCEC	chr3	52609510	Missense_Mutation	novel	M790I	0.35
UCEC	chr3	52586526	Missense_Mutation	novel	R1096C	0.49
UCEC	chr3	52603675	Missense_Mutation	novel	I875M	0.48
UCEC	chr3	52627315	Missense_Mutation	novel	I500S	0.47
UCEC	chr3	52648391	Missense_Mutation	rs776146971	A256T	0.4
UCEC	chr3	52546478	3'Flank	novel		0.15
UCEC	chr3	52546822	3'Flank	novel		0.41
UCEC	chr3	52589233	Silent	novel	S934S	0.35
UCEC	chr3	52609752	Nonsense_Mutation	NA	R710*	0.39
UCEC	chr3	52548046	3'UTR	novel		0.35
UCEC	chr3	52603687	Missense_Mutation	NA	F871L	0.28
UCEC	chr3	52546453	3'Flank	novel		0.11
UCEC	chr3	52548046	3'UTR	novel		0.26
UCEC	chr3	52564095	Missense_Mutation	novel	F1277C	0.17
UCEC	chr3	52609752	Nonsense_Mutation	NA	R710*	0.1
UCEC	chr3	52644764	Missense_Mutation	novel	F280S	0.12
UCEC	chr3	52658235	Silent	novel	L203L	0.4
UCEC	chr3	52546526	3'Flank	novel		0.27
UCEC	chr3	52548051	3'UTR	rs779338157		0.28
UCEC	chr3	52648368	In_Frame_Del	NA	N263del	0.17
UCEC	chr3	52546134	3'Flank	novel		0.36
UCEC	chr3	52548227	Missense_Mutation	NA	R1636C	0.08
UCEC	chr3	52662184	Silent	rs762326260	D159D	0.31
UCEC	chr3	52546884	3'Flank	novel		0.33
UCEC	chr3	52546381	3'Flank	rs548715456		0.38
UCEC	chr3	52589103	Missense_Mutation	rs375687372	V978I	0.3
UCEC	chr3	52609510	Missense_Mutation	novel	M790I	0.31
UCEC	chr3	52678512	Missense_Mutation	NA	A75V	0.08
UCEC	chr3	52634810	Missense_Mutation	rs147499494	R365C	0.4
UCEC	chr3	52634624	Missense_Mutation	NA	P427S	0.12
UCEC	chr3	52563422	Missense_Mutation	NA	F1316C	0.29
UCEC	chr3	52586606	Missense_Mutation	novel	S1069Y	0.31
UCEC	chr3	52617489	Missense_Mutation	novel	L531I	0.27
UCEC	chr3	52564146	Missense_Mutation	novel	R1260H	0.24
UCEC	chr3	52634698	Missense_Mutation	novel	Q402R	0.1
UCEC	chr3	52679692	Missense_Mutation	novel	R7I	0.18
UCEC	chr3	52586549	Missense_Mutation	NA	R1088Q	0.38
UCEC	chr3	52546209	3'Flank	novel		0.34
UCEC	chr3	52609356	Missense_Mutation	novel	E842Q	0.16
UCEC	chr3	52561955	Missense_Mutation	rs371730711	S1367F	0.42
UCEC	chr3	52603728	Missense_Mutation	novel	D858N	0.6
UCEC	chr3	52644768	Frame_Shift_Del	rs771618422	*I279Yfs4**	0.56
UCEC	chr3	52546692	3'Flank	novel		0.64
UCEC	chr3	52589146	Silent	novel	Y963Y	0.6
UCEC	chr3	52609844	Missense_Mutation	rs763078803	R679H	0.43
UCEC	chr3	52617354	Missense_Mutation	novel	R576C	0.41
UCEC	chr3	52558375	Nonsense_Mutation	novel	R1443*	0.45
UCEC	chr3	52609752	Nonsense_Mutation	NA	R710*	0.42
UCS	chr3	52576679	Nonsense_Mutation	NA	R1185*	0.28
UCS	chr3	52609752	Nonsense_Mutation	NA	R710*	0.25
UCS	chr3	52662183	Missense_Mutation	rs774655494	E160K	0.14

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.7778	0.016387
GBM	DEL	0.0849	0.056565
LGG	DEL	0.0799	0.00089193
LUAD	DEL	0.3295	0.0021265
PAAD	DEL	0.1902	0.030662
SARC	DEL	0.2179	0.0034746
SKCM	DEL	0.1635	0.13887
STAD	DEL	0.2789	1.0362e-08
TGCT	AMP	0.1467	0.23596
THYM	DEL	0.0894	0.037527
UCS	DEL	0.5	4.5515e-05

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0077	Kaplan-Meier Survival Analysis
KIRC	0.00099	Kaplan-Meier Survival Analysis
SARC	0.0044	Kaplan-Meier Survival Analysis
MESO	0.0089	Kaplan-Meier Survival Analysis
ACC	0.034	Kaplan-Meier Survival Analysis
HNSC	0.015	Kaplan-Meier Survival Analysis
SKCM	0.0038	Kaplan-Meier Survival Analysis
READ	0.0047	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
LIHC	0.012	Kaplan-Meier Survival Analysis
THCA	0.017	Kaplan-Meier Survival Analysis
UVM	0.042	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000163939 (Gene tree)
Gene ID: 55193
Gene Symbol: PBRM1
Alias: BAF180|PB1
Full Name: polybromo 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 140,566 bases
Position: chr3:52,545,352-52,685,917
Accession: 30064
Summary: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000431678	PBRM1-213	809	-	ENSP00000409939	230 (aa)	-	C9JPI5
ENST00000480064	PBRM1-220	919	-	-	- (aa)	-	-
ENST00000450271	PBRM1-217	517	-	ENSP00000416851	87 (aa)	-	C9JCJ2
ENST00000446103	PBRM1-215	3256	-	ENSP00000397662	1085 (aa)	-	H0Y5B5
ENST00000409057	PBRM1-205	4980	XM_017006753	ENSP00000386593	1634 (aa)	XP_016862242	Q86U86
ENST00000409114	PBRM1-206	5015	XM_017006752	ENSP00000386643	1652 (aa)	XP_016862241	Q86U86
ENST00000356770	PBRM1-203	7523	-	ENSP00000349213	1602 (aa)	-	Q86U86
ENST00000410007	PBRM1-208	4905	XM_017006759	ENSP00000386529	1609 (aa)	XP_016862248	Q86U86
ENST00000296302	PBRM1-201	5145	XM_005265279	ENSP00000296302	1689 (aa)	XP_005265336	Q86U86
ENST00000420148	PBRM1-210	783	-	ENSP00000389390	152 (aa)	-	C9JQF1
ENST00000409767	PBRM1-207	4849	-	ENSP00000386601	1597 (aa)	-	Q86U86
ENST00000337303	PBRM1-202	4825	XM_017006764	ENSP00000338302	1582 (aa)	XP_016862253	Q86U86
ENST00000412587	PBRM1-209	4766	-	ENSP00000404579	856 (aa)	-	Q86U86
ENST00000449505	PBRM1-216	517	-	ENSP00000412401	118 (aa)	-	C9J053
ENST00000462207	PBRM1-219	1921	-	-	- (aa)	-	-
ENST00000458294	PBRM1-218	476	-	ENSP00000411895	43 (aa)	-	C9J409
ENST00000424867	PBRM1-212	457	-	ENSP00000397399	26 (aa)	-	C9J9L6
ENST00000423351	PBRM1-211	4385	-	ENSP00000387775	1460 (aa)	-	E7EVG2
ENST00000394830	PBRM1-204	5071	-	ENSP00000378307	1582 (aa)	-	Q86U86
ENST00000439181	PBRM1-214	547	-	ENSP00000404635	43 (aa)	-	C9J409

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa05225	Hepatocellular carcinoma	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000163939	Respiratory Function Tests	6.334248366624E-5	17903307
ENSG00000163939	gamma-Globulins	5.3740000E-005	-
ENSG00000163939	gamma-Globulins	3.3360000E-005	-
ENSG00000163939	gamma-Globulins	3.2180000E-005	-
ENSG00000163939	gamma-Globulins	2.7580000E-005	-
ENSG00000163939	Adiponectin	1E-13	22479202
ENSG00000163939	Body Mass Index	7E-11	25673412
ENSG00000163939	Waist-Hip Ratio	7E-11	25673412
ENSG00000163939	Osteoarthritis	5E-9	22763110
ENSG00000163939	Body Mass Index	1E-8	25673412
ENSG00000163939	Waist-Hip Ratio	1E-8	25673412
ENSG00000163939	Body Mass Index	4E-11	25673412
ENSG00000163939	Waist-Hip Ratio	4E-11	25673412
ENSG00000163939	Body Mass Index	5E-10	25673412
ENSG00000163939	Waist-Hip Ratio	5E-10	25673412
ENSG00000163939	Body Mass Index	3E-11	25673412
ENSG00000163939	Waist-Hip Ratio	3E-11	25673412
ENSG00000163939	Adiponectin	2E-13	22479202
ENSG00000163939	Bipolar Disorder	2E-6	23092984
ENSG00000163939	Body Mass Index	2E-9	25673412
ENSG00000163939	Waist-Hip Ratio	2E-9	25673412
ENSG00000163939	Mood Disorders	2E-9	20081856
ENSG00000163939	Body Mass Index	7E-11	25673412
ENSG00000163939	Waist-Hip Ratio	7E-11	25673412
ENSG00000163939	Body Mass Index	4E-9	25673412
ENSG00000163939	Waist-Hip Ratio	4E-9	25673412

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163939	rs12493107	3	52672708	T	Blood protein levels	29875488	[0.12-0.24] unit decrease	0.18	EFO_0007937
ENSG00000163939	rs34218707	3	52666891	C	Blood protein levels	29875488	[0.35-0.47] unit increase	0.41	EFO_0007937
ENSG00000163939	rs10865974	3	52684264	?	Bipolar disorder with mood-incongruent psychosis	23092984	[NR]	1.19	EFO_0000289
ENSG00000163939	rs2251219	3	52550771	?	Major mood disorders	20081856	[1.09-1.18]	1.14	EFO_0004247
ENSG00000163939	rs2577831	3	52594040	C	Schizophrenia	28991256	[1.05-1.09]	1.0683761	EFO_0000692
ENSG00000163939	rs2878628	3	52550699	A	Intelligence (MTAG)	29326435	[0.011-0.023] unit decrease	0.016829833	EFO_0004337
ENSG00000163939	rs9879090	3	52614249	T	Feeling nervous	29500382	z score increase	6.03	EFO_0009597
ENSG00000163939	rs60311166	3	52637054	G	CTACK levels	27989323	[0.41-1.04] SD units increase	0.7233	EFO_0008082
ENSG00000163939	rs9864989	3	52650349	?	Systolic blood pressure	28498854	[1.62-3.92] unit increase	2.77	EFO_0006335
ENSG00000163939	rs9864989	3	52650349	?	Diastolic blood pressure	28498854	[1.64-1.64] unit increase	1.6431	EFO_0006336
ENSG00000163939	rs9864989	3	52650349	?	Hypertension	28498854	[0.20-0.50] unit increase	0.3463	EFO_0000537
ENSG00000163939	rs2590838	3	52588070	G	Adiponectin levels	22479202	[0.022-0.038] unit decrease	0.03	EFO_0004502
ENSG00000163939	rs13083798	3	52615732	A	Waist circumference adjusted for body mass index	28448500	[0.023-0.042] cm increase	0.0325	EFO_0007789\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	A	Waist circumference adjusted for body mass index	28448500	[0.017-0.031] cm increase	0.0242	EFO_0007789\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	A	Waist circumference adjusted for body mass index	28448500	[0.015-0.028] cm increase	0.0216	EFO_0007789\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	A	Waist circumference adjusted for BMI in active individuals	28448500	[0.023-0.044] cm increase	0.0335	EFO_0007789\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	A	Waist circumference adjusted for BMI in active individuals	28448500	[0.017-0.033] cm increase	0.0252	EFO_0007789\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	A	Waist circumference adjusted for BMI in active individuals	28448500	[0.015-0.031] cm increase	0.0229	EFO_0007789\|EFO_0008002
ENSG00000163939	rs2590838	3	52588070	G	Waist-to-hip ratio adjusted for body mass index	28448500	[0.018-0.038] unit increase	0.0276	EFO_0007788\|EFO_0008002
ENSG00000163939	rs2590838	3	52588070	G	Waist-to-hip ratio adjusted for body mass index	28448500	[0.016-0.031] unit increase	0.0235	EFO_0007788\|EFO_0008002
ENSG00000163939	rs2590838	3	52588070	G	Waist-to-hip ratio adjusted for BMI in active individuals	28448500	[0.015-0.038] unit increase	0.0264	EFO_0007788\|EFO_0008002
ENSG00000163939	rs2590838	3	52588070	G	Waist-to-hip ratio adjusted for BMI in active individuals	28448500	[0.015-0.033] unit increase	0.0242	EFO_0007788\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.019-0.037] unit increase	0.0283	EFO_0007788
ENSG00000163939	rs13083798	3	52615732	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.016-0.029] unit increase	0.0227	EFO_0007788
ENSG00000163939	rs13083798	3	52615732	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.018-0.036] unit increase	0.0268	EFO_0007788
ENSG00000163939	rs13083798	3	52615732	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.015-0.028] unit increase	0.0218	EFO_0007788
ENSG00000163939	rs2276824	3	52603470	C	Waist-to-hip ratio adjusted for body mass index	25673412	[0.019-0.037] unit increase	0.028	EFO_0007788
ENSG00000163939	rs2276824	3	52603470	C	Waist-to-hip ratio adjusted for body mass index	25673412	[0.017-0.031] unit increase	0.0236	EFO_0007788
ENSG00000163939	rs2276824	3	52603470	C	Waist-to-hip ratio adjusted for body mass index	25673412	[0.017-0.036] unit increase	0.0265	EFO_0007788
ENSG00000163939	rs2276824	3	52603470	C	Waist-to-hip ratio adjusted for body mass index	25673412	[0.016-0.029] unit increase	0.0224	EFO_0007788
ENSG00000163939	rs2276824	3	52603470	C	Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.012-0.027] unit increase	0.0193	EFO_0004318\|EFO_0007788
ENSG00000163939	rs2276824	3	52603470	C	Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.012-0.031] unit increase	0.0215	EFO_0004318\|EFO_0007788
ENSG00000163939	rs13083798	3	52615732	A	Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.013-0.027] unit increase	0.0198	EFO_0004318\|EFO_0007788
ENSG00000163939	rs13083798	3	52615732	A	Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.012-0.029] unit increase	0.0204	EFO_0004318\|EFO_0007788
ENSG00000163939	rs13083798	3	52615732	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000163939	rs13083798	3	52615732	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000163939	rs2590838	3	52588070	?	Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction)	28448500			EFO_0007788\|EFO_0008002
ENSG00000163939	rs2590838	3	52588070	?	Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction)	28448500			EFO_0007788\|EFO_0008002
ENSG00000163939	rs9879090	3	52614249	T	General cognitive ability	29844566	z-score decrease	7.075	EFO_0004337
ENSG00000163939	rs2590838	3	52588070	G	Body mass index	30108127	[NR] unit decrease	0.012	EFO_0004340
ENSG00000163939	rs13083798	3	52615732	A	Automobile speeding propensity	30643258	[0.0079-0.0167] unit decrease	0.012325772	EFO_0008579
ENSG00000163939	rs10933	3	52685800	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000163939	rs2577831	3	52594040	?	Red blood cell count	30595370			EFO_0004305
ENSG00000163939	rs55946513	3	52565776	C	Insomnia symptoms (never/rarely vs. sometimes/usually)	30804566	[1.01-1.06]	1.04	EFO_0007876
ENSG00000163939	rs565817433	3	52684168	C	Body fat distribution (leg fat ratio)	30664634	NR unit increase (replication)	0.01066	EFO_0004341
ENSG00000163939	rs2577831	3	52594040	C	Schizophrenia	30285260	[1.05-1.09]	1.0695187	EFO_0000692
ENSG00000163939	rs2577831	3	52594040	A	Schizophrenia	30285260	[1.05-1.09]	1.0689	EFO_0000692
ENSG00000163939	rs565817433	3	52684168	C	Body fat distribution (trunk fat ratio)	30664634	NR unit decrease (replication)	0.02074	EFO_0004341
ENSG00000163939	rs565817433	3	52684168	C	Body fat distribution (trunk fat ratio)	30664634	NR unit decrease (replication)	0.01312	EFO_0004341
ENSG00000163939	rs565817433	3	52684168	C	Body fat distribution (leg fat ratio)	30664634	NR unit increase (replication)	0.01704	EFO_0004341

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163939's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163939	PBRM1	100	100.000	ENSMUSG00000042323	Pbrm1	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000228	nuclear chromosome	11078522.	NAS	Component
GO:0000278	mitotic cell cycle	11078522.	TAS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0003682	chromatin binding	11078522.	NAS	Function
GO:0005515	protein binding	11780067.12368262.15985610.20130577.22140357.27142060.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006337	nucleosome disassembly	21873635.	IBA	Process
GO:0006338	chromatin remodeling	11078522.	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0008285	negative regulation of cell proliferation	21248752.	IMP	Process
GO:0015616	DNA translocase activity	21873635.	IBA	Function
GO:0016586	RSC-type complex	21873635.	IBA	Component
GO:0043044	ATP-dependent chromatin remodeling	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.