EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19553003	In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16.	Cancer Lett	2010 Jan 1	Mazibrada J	doi: 10.1016/j.canlet.2009.05.035
22618232	Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.	Biochem Biophys Res Commun	2012 Jun 15	Br??zda V	doi: 10.1016/j.bbrc.2012.05.065
17339605	IFI16 in human prostate cancer.	Mol Cancer Res	2007 Mar	Alimirah F	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	159051941	Missense_Mutation	novel	E643V	0.24
BLCA	chr1	159032530	Missense_Mutation	novel	K390Q	0.09
BLCA	chr1	159016601	Missense_Mutation	novel	Q150H	0.11
BLCA	chr1	159014924	Missense_Mutation	novel	L82V	0.08
BLCA	chr1	159020387	Missense_Mutation	novel	R340T	0.35
BLCA	chr1	159014933	Missense_Mutation	novel	E85Q	0.26
BLCA	chr1	159014718	Missense_Mutation	novel	G13V	0.25
BLCA	chr1	159049558	Nonsense_Mutation	novel	Q542*	0.41
BLCA	chr1	159014915	Missense_Mutation	novel	A79P	0.36
BLCA	chr1	159045425	Missense_Mutation	novel	Q486H	0.23
BLCA	chr1	159051735	Silent	rs779668092	Q574Q	0.44
BLCA	chr1	159015967	Missense_Mutation	NA	E121Q	0.27
BLCA	chr1	159014819	Nonsense_Mutation	novel	Q47*	0.13
BLCA	chr1	159045402	Missense_Mutation	NA	E479K	0.22
BRCA	chr1	159020418	Silent	rs774647644	Q350Q	0.25
BRCA	chr1	159051854	Missense_Mutation	NA	K614M	0.56
BRCA	chr1	159015921	Silent	NA	T105T	0.16
BRCA	chr1	159032552	Missense_Mutation	NA	N397S	0.18
BRCA	chr1	159014685	Missense_Mutation	novel	G2E	0.08
BRCA	chr1	159052053	Silent	NA	S680S	0.22
BRCA	chr1	159032659	Missense_Mutation	novel	P433T	0.05
BRCA	chr1	159015897	Missense_Mutation	NA	K97N	0.27
BRCA	chr1	159051735	Silent	rs779668092	Q574Q	0.14
BRCA	chr1	159018328	Missense_Mutation	novel	E217K	0.11
BRCA	chr1	159053532	Splice_Site	novel	X696_splice	0.07
CESC	chr1	159052003	Nonsense_Mutation	NA	G664*	0.53
CESC	chr1	159051832	Missense_Mutation	novel	E607Q	0.43
CESC	chr1	159018572	Missense_Mutation	novel	A298E	0.24
CESC	chr1	159053697	Missense_Mutation	NA	L750F	0.06
CESC	chr1	159015966	Silent	novel	A120A	0.5
CESC	chr1	159020502	Silent	NA	L378L	0.35
CESC	chr1	159032629	Missense_Mutation	NA	E423K	0.2
CESC	chr1	159049512	Silent	novel	P526P	0.11
CESC	chr1	159032650	Nonsense_Mutation	novel	Q430*	0.31
CHOL	chr1	159055069	3'UTR	novel		0.3
COAD	chr1	159045306	Missense_Mutation	NA	D447Y	0.41
COAD	chr1	159000100	5'UTR	novel		0.4
COAD	chr1	159018297	Missense_Mutation	NA	I206M	0.38
COAD	chr1	159018234	Silent	rs370784049	P185P	0.26
COAD	chr1	159054953	3'UTR	novel		0.3
COAD	chr1	159032571	Missense_Mutation	NA	K403N	0.12
COAD	chr1	159054900	Frame_Shift_Del	rs757602743		0.31
COAD	chr1	159020467	Missense_Mutation	NA	F367V	0.25
COAD	chr1	159054953	3'UTR	novel		0.41
COAD	chr1	159054953	3'UTR	novel		0.4
COAD	chr1	159052019	Missense_Mutation	NA	A669V	0.29
COAD	chr1	159053689	Missense_Mutation	NA	G748W	0.33
COAD	chr1	159054953	3'UTR	novel		0.13
COAD	chr1	159051842	Missense_Mutation	novel	V610A	0.09
COAD	chr1	159016661	Missense_Mutation	NA	K170N	0.39
COAD	chr1	159054953	3'UTR	novel		0.2
COAD	chr1	159055051	3'UTR	novel		0.26
COAD	chr1	159054953	3'UTR	novel		0.23
COAD	chr1	159018351	Frame_Shift_Ins	NA	*I227Nfs42**	0.46
COAD	chr1	159015952	Missense_Mutation	NA	K116Q	0.09
COAD	chr1	159016693	Nonsense_Mutation	novel	S181*	0.1
COAD	chr1	159014901	Missense_Mutation	NA	T74M	0.36
COAD	chr1	159051837	Silent	NA	N608N	0.47
COAD	chr1	159020470	Nonsense_Mutation	NA	R368*	0.33
COAD	chr1	159051926	Missense_Mutation	rs758208458	R638H	0.24
COAD	chr1	159051848	Missense_Mutation	rs746538717	R612Q	0.19
COAD	chr1	159000318	5'UTR	novel		0.2
COAD	chr1	159014901	Missense_Mutation	NA	T74M	0.13
COAD	chr1	159014686	Frame_Shift_Del	NA	*K4Nfs8**	0.16
COAD	chr1	159018351	Missense_Mutation	NA	E224D	0.22
COAD	chr1	159045451	Missense_Mutation	NA	S495N	0.36
COAD	chr1	159051711	Missense_Mutation	rs777391755	E566D	0.21
COAD	chr1	159020506	Nonsense_Mutation	novel	*S380Yfs5**	0.11
COAD	chr1	159055069	3'UTR	novel		0.44
ESCA	chr1	159054835	Missense_Mutation	novel	R764S	0.11
ESCA	chr1	159016645	Missense_Mutation	rs138795047	R165H	0.23
ESCA	chr1	159032554	Missense_Mutation	novel	D398N	0.2
ESCA	chr1	159015955	Missense_Mutation	NA	T117P	0.4
ESCA	chr1	159051893	Missense_Mutation	novel	K627T	0.26
ESCA	chr1	159053598	Silent	novel	V717V	0.04
ESCA	chr1	159016587	Missense_Mutation	novel	E146Q	0.1
ESCA	chr1	159049442	Missense_Mutation	novel	D503G	0.21
ESCA	chr1	159018239	Frame_Shift_Del	novel	*V188Nfs4**	0.15
GBM	chr1	159045442	Missense_Mutation	NA	P492Q	0.37
GBM	chr1	159053672	Missense_Mutation	rs772714012	P742L	0.34
GBM	chr1	159015886	Silent	novel	L94L	0.71
GBM	chr1	159014793	Missense_Mutation	novel	K38T	0.08
GBM	chr1	159014901	Missense_Mutation	NA	T74M	0.51
GBM	chr1	159016622	Silent	NA	A157A	0.16
GBM	chr1	159016700	Missense_Mutation	novel	E183D	0.15
GBM	chr1	159051838	Nonsense_Mutation	novel	E609*	0.33
HNSC	chr1	159020386	Nonsense_Mutation	novel	R340*	0.17
HNSC	chr1	159015923	Missense_Mutation	novel	S106L	0.08
HNSC	chr1	159049485	Silent	novel	L517L	0.11
HNSC	chr1	159051900	Missense_Mutation	novel	I629M	0.15
HNSC	chr1	159045423	Nonsense_Mutation	novel	Q486*	0.08
HNSC	chr1	159049567	Missense_Mutation	novel	P545A	0.08
HNSC	chr1	159032650	Missense_Mutation	novel	Q430E	0.05
KICH	chr1	159053708	Missense_Mutation	novel	I754T	0.11
KIRC	chr1	159055001	3'UTR	novel		0.29
KIRC	chr1	159018576	Silent	NA	K299K	0.33
KIRC	chr1	159032683	Frame_Shift_Ins	novel	*F441Sfs13**	0.06
KIRC	chr1	159032512	Intron	novel		0.39
KIRP	chr1	159032509	Intron	novel		0.43
LGG	chr1	159014686	Frame_Shift_Del	NA	*K4Nfs8**	0.14
LGG	chr1	159045428	Missense_Mutation	novel	M487I	0.17
LGG	chr1	159018464	Missense_Mutation	NA	S262L	0.13
LGG	chr1	159054963	3'UTR	novel		0.43
LIHC	chr1	159014845	Missense_Mutation	NA	K55N	0.23
LIHC	chr1	159045424	Missense_Mutation	NA	Q486L	0.17
LIHC	chr1	159032531	Missense_Mutation	NA	K390R	0.1
LIHC	chr1	159018284	Missense_Mutation	NA	K202I	0.33
LUAD	chr1	159032552	Missense_Mutation	rs748916757	N397I	0.17
LUAD	chr1	159018340	Missense_Mutation	NA	P221A	0.12
LUAD	chr1	159016568	Silent	NA	P139P	0.4
LUAD	chr1	159032615	Missense_Mutation	NA	S418N	0.33
LUAD	chr1	159000271	5'UTR	novel		0.59
LUAD	chr1	159000258	5'UTR	novel		0.42
LUAD	chr1	159051699	Silent	novel	T562T	0.42
LUAD	chr1	159051700	Nonsense_Mutation	novel	E563*	0.42
LUAD	chr1	159053681	Missense_Mutation	novel	G745E	0.14
LUAD	chr1	159020487	Missense_Mutation	novel	N373K	0.12
LUAD	chr1	159000298	5'UTR	novel		0.14
LUAD	chr1	159020412	Silent	NA	T348T	0.24
LUAD	chr1	159018592	Missense_Mutation	NA	D305N	0.14
LUAD	chr1	159049591	Missense_Mutation	NA	L553V	0.12
LUAD	chr1	159053619	Silent	novel	T724T	0.39
LUAD	chr1	159020473	Missense_Mutation	novel	L369F	0.18
LUAD	chr1	159049492	Missense_Mutation	novel	G520W	0.3
LUAD	chr1	159032572	Missense_Mutation	NA	L404V	0.25
LUAD	chr1	159032506	Intron	novel		0.43
LUAD	chr1	159018631	Missense_Mutation	NA	G318W	0.11
LUAD	chr1	159014748	Missense_Mutation	NA	R23K	0.1
LUAD	chr1	159053569	Missense_Mutation	rs778037142	Q708E	0.14
LUAD	chr1	159053624	Missense_Mutation	rs202009746	N726T	0.05
LUAD	chr1	159051787	Missense_Mutation	novel	E592Q	0.04
LUAD	chr1	159053578	Missense_Mutation	novel	T711S	0.17
LUSC	chr1	159018433	Missense_Mutation	rs372267762	K252E	0.23
LUSC	chr1	159014896	Silent	novel	I72I	0.21
LUSC	chr1	159049441	Missense_Mutation	novel	D503Y	0.23
LUSC	chr1	159018598	Missense_Mutation	NA	L307V	0.22
LUSC	chr1	159045370	Missense_Mutation	novel	P468Q	0.57
LUSC	chr1	159051906	Silent	NA	A631A	0.14
LUSC	chr1	159015874	Missense_Mutation	NA	K90Q	0.45
LUSC	chr1	159032530	Nonsense_Mutation	NA	K390*	0.6
OV	chr1	159051856	Missense_Mutation	NA	V615I	0.16
OV	chr1	159053682	Silent	NA	G745G	0.42
OV	chr1	159054940	3'UTR	novel		0.23
PAAD	chr1	159014681	Translation_Start_Site	novel	M1?	0.25
PAAD	chr1	159018524	Missense_Mutation	novel	A282V	0.28
PRAD	chr1	159018646	Missense_Mutation	NA	H323Y	0.52
PRAD	chr1	159018337	Missense_Mutation	NA	T220A	0.47
PRAD	chr1	159032601	Nonsense_Mutation	novel	Y413*	0.27
PRAD	chr1	159014887	Silent	rs144369567	F69F	0.21
PRAD	chr1	159014896	Missense_Mutation	novel	I72M	0.36
READ	chr1	159051842	Missense_Mutation	novel	V610A	0.27
READ	chr1	159045380	Missense_Mutation	novel	F471L	0.08
READ	chr1	159053673	Silent	novel	P742P	0.16
READ	chr1	159055061	3'UTR	novel		0.57
SKCM	chr1	159018564	Silent	rs149200088	I295I	0.26
SKCM	chr1	159045332	Silent	novel	F455F	0.28
SKCM	chr1	159016567	Missense_Mutation	novel	P139L	0.22
SKCM	chr1	159051996	Silent	novel	I661I	0.35
SKCM	chr1	159053673	Silent	novel	P742P	0.37
SKCM	chr1	159045323	Missense_Mutation	novel	M452I	0.36
SKCM	chr1	159049568	Missense_Mutation	novel	P545L	0.27
SKCM	chr1	159053652	Silent	NA	L735L	0.43
STAD	chr1	159051711	Missense_Mutation	rs777391755	E566D	0.12
STAD	chr1	159016579	Missense_Mutation	novel	K143R	0.28
STAD	chr1	159052092	Silent	novel	V693V	0.35
STAD	chr1	159016645	Missense_Mutation	rs138795047	R165H	0.24
STAD	chr1	159051970	Missense_Mutation	novel	V653L	0.25
STAD	chr1	159051982	Nonsense_Mutation	rs747530999	R657*	0.09
STAD	chr1	159054953	3'UTR	novel		0.26
STAD	chr1	159015938	Missense_Mutation	novel	T111R	0.06
STAD	chr1	159014794	Missense_Mutation	NA	K38N	0.12
STAD	chr1	159018627	Silent	rs756278477	V316V	0.39
STAD	chr1	159018337	Missense_Mutation	NA	T220A	0.28
STAD	chr1	159014927	Frame_Shift_Del	NA	*E85Kfs3**	0.23
STAD	chr1	159053536	Missense_Mutation	NA	N697H	0.62
STAD	chr1	159016543	Missense_Mutation	NA	K131T	0.09
STAD	chr1	159016629	Missense_Mutation	NA	S160T	0.08
STAD	chr1	159032585	Missense_Mutation	novel	Q408L	0.15
STAD	chr1	159049591	Missense_Mutation	NA	L553V	0.15
STAD	chr1	159049476	Missense_Mutation	novel	M514I	0.33
STAD	chr1	159051982	Nonsense_Mutation	rs747530999	R657*	0.25
STAD	chr1	159014927	Frame_Shift_Del	NA	*E85Kfs3**	0.1
STAD	chr1	159051926	Missense_Mutation	rs758208458	R638H	0.18
STAD	chr1	159051698	Missense_Mutation	novel	T562S	0.35
STAD	chr1	159053699	Missense_Mutation	NA	R751T	0.07
STAD	chr1	159051983	Missense_Mutation	rs766761172	R657Q	0.35
STAD	chr1	159045456	Missense_Mutation	NA	L497V	0.14
THCA	chr1	159020471	Missense_Mutation	NA	R368Q	0.47
UCEC	chr1	159015893	Missense_Mutation	NA	R96I	0.34
UCEC	chr1	159054982	3'UTR	novel		0.29
UCEC	chr1	159049590	Missense_Mutation	NA	F552L	0.17
UCEC	chr1	159014725	Missense_Mutation	NA	E15D	0.17
UCEC	chr1	159014887	Silent	rs144369567	F69F	0.31
UCEC	chr1	159032616	Silent	novel	S418S	0.07
UCEC	chr1	159018396	Missense_Mutation	NA	F239L	0.34
UCEC	chr1	159051804	Missense_Mutation	NA	K597N	0.39
UCEC	chr1	159014832	Missense_Mutation	novel	L51S	0.45
UCEC	chr1	159032579	Missense_Mutation	rs769967836	Q406R	0.36
UCEC	chr1	159016589	Missense_Mutation	novel	E146D	0.38
UCEC	chr1	159055069	3'UTR	novel		0.5
UCEC	chr1	159018436	Missense_Mutation	novel	F253L	0.4
UCEC	chr1	159018351	Frame_Shift_Ins	NA	*I227Nfs42**	0.45
UCEC	chr1	159051781	Missense_Mutation	novel	V590I	0.29
UCEC	chr1	159018234	Silent	rs370784049	P185P	0.31
UCEC	chr1	159032630	Missense_Mutation	novel	E423A	0.1
UCEC	chr1	159014774	Missense_Mutation	NA	D32N	0.14
UCEC	chr1	159018611	Missense_Mutation	novel	A311D	0.16
UCEC	chr1	159032627	Missense_Mutation	novel	P422L	0.22
UCEC	chr1	159054953	3'UTR	novel		0.46
UCEC	chr1	159053563	Nonsense_Mutation	novel	E706*	0.28
UCEC	chr1	159014932	Silent	novel	K84K	0.15
UCEC	chr1	159051847	Silent	novel	R612R	0.21
UCEC	chr1	159051728	Missense_Mutation	novel	S572N	0.2
UCEC	chr1	159018495	Missense_Mutation	novel	E272D	0.4
UCEC	chr1	159055069	3'UTR	novel		0.38
UCEC	chr1	159054953	3'UTR	novel		0.58
UCEC	chr1	159018343	Nonsense_Mutation	novel	E222*	0.14
UCEC	chr1	159054876	Missense_Mutation	novel	E778V	0.38
UCEC	chr1	159015970	Missense_Mutation	novel	A122T	0.56
UCEC	chr1	159049493	Missense_Mutation	novel	G520E	0.29
UCEC	chr1	159051866	Missense_Mutation	novel	I618N	0.27
UCEC	chr1	159051982	Nonsense_Mutation	rs747530999	R657*	0.28
UCEC	chr1	159018299	Missense_Mutation	NA	V207A	0.21
UCEC	chr1	159014804	Nonsense_Mutation	novel	E42*	0.58
UCEC	chr1	159020478	Frame_Shift_Del	novel	*K372Rfs7**	0.5
UCEC	chr1	159014879	Missense_Mutation	novel	K67Q	0.53
UCEC	chr1	159045329	Missense_Mutation	novel	D454E	0.33
UCEC	chr1	159054895	Missense_Mutation	novel	F784L	0.38
UCEC	chr1	159020451	Silent	novel	K361K	0.33
UCEC	chr1	159045386	Silent	novel	T473T	0.46
UCEC	chr1	159052023	Silent	rs773070697	S670S	0.24
UCEC	chr1	159020371	Missense_Mutation	rs75796001	E335K	0.12
UCEC	chr1	159032647	Missense_Mutation	novel	P429S	0.36
UCEC	chr1	159014774	Missense_Mutation	NA	D32N	0.29
UCEC	chr1	159020470	Nonsense_Mutation	NA	R368*	0.24
UCEC	chr1	159032529	Frame_Shift_Ins	NA	*T392Nfs7**	0.35
UCEC	chr1	159018432	Missense_Mutation	novel	E251D	0.26
UCEC	chr1	159032571	Silent	NA	K403K	0.29
UCEC	chr1	159014909	Missense_Mutation	novel	D77N	0.33
UCEC	chr1	159018245	Missense_Mutation	novel	A189V	0.41
UCEC	chr1	159016643	Silent	novel	G164G	0.29
UCEC	chr1	159054953	3'UTR	novel		0.16
UCEC	chr1	159049546	Missense_Mutation	novel	P538S	0.08
UCEC	chr1	159051892	Missense_Mutation	novel	K627Q	0.14
UCEC	chr1	159014736	Missense_Mutation	novel	D19G	0.13
UCEC	chr1	159018539	Missense_Mutation	rs145736033	T287M	0.28
UCEC	chr1	159032571	Silent	NA	K403K	0.16
UCEC	chr1	159054911	3'UTR	novel		0.06
UCEC	chr1	159054912	3'UTR	novel		0.06
UCEC	chr1	159020477	Frame_Shift_Ins	novel	*N373Efs12**	0.35
UCEC	chr1	159018290	Missense_Mutation	NA	P204Q	0.35
UCEC	chr1	159054953	3'UTR	novel		0.24
UCEC	chr1	159018598	Missense_Mutation	NA	L307I	0.47
UCEC	chr1	159054953	3'UTR	novel		0.23
UCEC	chr1	159018557	Missense_Mutation	NA	K293T	0.11
UCEC	chr1	159049504	Missense_Mutation	NA	P524T	0.32
UCEC	chr1	159045337	Missense_Mutation	novel	R457M	0.47
UCEC	chr1	159051804	Missense_Mutation	NA	K597N	0.18
UCEC	chr1	159032531	Missense_Mutation	NA	K390R	0.22
UCEC	chr1	159052038	Silent	novel	I675I	0.22
UCEC	chr1	159032633	Missense_Mutation	novel	S424N	0.34
UCEC	chr1	159016538	Frame_Shift_Del	rs750703064	*K131Nfs63**	0.11
UCEC	chr1	159016686	Missense_Mutation	rs757244892	S179G	0.13
UCEC	chr1	159045312	Missense_Mutation	NA	I449L	0.14
UCEC	chr1	159049598	Missense_Mutation	NA	T555M	0.16
UCEC	chr1	159014927	Frame_Shift_Del	NA	*E85Kfs3**	0.4
UCEC	chr1	159018513	Silent	novel	T278T	0.25
UCEC	chr1	159054844	Silent	novel	K767K	0.22
UCEC	chr1	159053688	Silent	rs753132913	T747T	0.56
UCS	chr1	159032558	Missense_Mutation	novel	P399L	0.43
UCS	chr1	159014887	Silent	rs144369567	F69F	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.4076	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2228	0.085665
READ	AMP	0.2667	0.025154
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.3333	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.029	Kaplan-Meier Survival Analysis
UCS	0.014	Kaplan-Meier Survival Analysis
SKCM	0.017	Kaplan-Meier Survival Analysis
BRCA	0.038	Kaplan-Meier Survival Analysis
KIRP	0.00092	Kaplan-Meier Survival Analysis
PAAD	0.0023	Kaplan-Meier Survival Analysis
CESC	0.041	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.018	Kaplan-Meier Survival Analysis
OV	0.041	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000163565 (Gene tree)
Gene ID: 3428
Gene Symbol: IFI16
Alias: IFNGIP1|PYHIN2
Full Name: interferon gamma inducible protein 16
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 55,188 bases
Position: chr1:158,999,968-159,055,155
Accession: 5395
Summary: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17699163	A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells.	J Biol Chem	2007 Nov 16	Caposio P	-
25375629	IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications.	PLoS Pathog	2014 Nov 6	Johnson KE	doi: 10.1371/journal.ppat.1004503

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368131	IFI16-204	2734	XM_017001150	ENSP00000357113	729 (aa)	XP_016856639	Q16666
ENST00000368132	IFI16-205	2704	-	ENSP00000357114	729 (aa)	-	Q16666
ENST00000493884	IFI16-211	4138	-	-	- (aa)	-	-
ENST00000447473	IFI16-207	951	-	ENSP00000407052	180 (aa)	-	X6RHM1
ENST00000295809	IFI16-201	2867	XM_005245127	ENSP00000295809	785 (aa)	-	Q16666
ENST00000562225	IFI16-212	1108	-	-	- (aa)	-	-
ENST00000567661	IFI16-214	546	-	ENSP00000456094	74 (aa)	-	H3BR65
ENST00000483916	IFI16-210	4138	-	-	- (aa)	-	-
ENST00000340979	IFI16-202	2732	-	ENSP00000342741	243 (aa)	-	A0A0A0MRB1
ENST00000448393	IFI16-208	2245	XM_006711290	ENSP00000404325	673 (aa)	XP_006711353	Q16666
ENST00000566111	IFI16-213	856	-	ENSP00000458084	83 (aa)	-	H3BVE6
ENST00000359709	IFI16-203	2609	-	ENSP00000352740	729 (aa)	-	Q16666
ENST00000426592	IFI16-206	761	-	ENSP00000406406	167 (aa)	-	H3BM18
ENST00000474473	IFI16-209	1095	-	ENSP00000456129	229 (aa)	-	H3BR88

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04621	NOD-like receptor signaling pathway	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000163565	Platelet Function Tests	4.2500000E-007	-
ENSG00000163565	Platelet Function Tests	3.4000000E-006	-
ENSG00000163565	Blood Pressure	9.2912734E-005	-
ENSG00000163565	Blood Pressure	1.3910835E-007	-
ENSG00000163565	Leukocyte Count	5E-47	23263863
ENSG00000163565	Autoimmune Diseases	8E-7	21383967
ENSG00000163565	Energy Intake	1E-6	23251661
ENSG00000163565	Periodontitis	3E-8	26962152
ENSG00000163565	Tooth	3E-8	26962152
ENSG00000163565	Neutrophils	3E-6	25884002
ENSG00000163565	HIV-1	3E-6	25884002

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163565	rs1633266	1	159036187	?	Periodontal disease-related phenotypes	26962152	[0.6-1.26] unit increase	0.93	EFO_0000649\|EFO_0007780
ENSG00000163565	rs2570916	1	159042856	?	Neutrophil count in HIV-infection	25884002	[NR] unit decrease	0.041722316	EFO_0004833\|EFO_0000180
ENSG00000163565	rs4657616	1	159001296	G	Hematology traits	23263863	[0.053-0.07] unit increase	0.0612	EFO_0004308
ENSG00000163565	rs861318	1	159032432	A	Obesity-related traits	23251661	[NR] g/d increase	0.04	EFO_0003939
ENSG00000163565	rs72709516	1	159035061	T	Blood protein levels	29875488	[0.73-0.97] unit increase	0.85	EFO_0007937
ENSG00000163565	rs12727764	1	159012687	G	Monocyte chemoattractant protein-1 levels	27989323	[0.055-0.139] SD units decrease	0.0971	EFO_0004749
ENSG00000163565	rs1772408	1	159035859	?	Celiac disease or Rheumatoid arthritis	21383967			EFO_0000540

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163565's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163565	IFI16	95	62.025	ENSMUSG00000090272	Mndal	84	61.628	Mus_musculus
ENSG00000163565	IFI16	85	41.546	ENSMUSG00000037860	Aim2	100	42.029	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	12894224.24413532.	IDA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	22046441.	IMP	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	24413532.	IDA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	24413532.	IDA	Function
GO:0001819	positive regulation of cytokine production	22046441.	TAS	Process
GO:0002218	activation of innate immune response	21575908.	IDA	Process
GO:0003690	double-stranded DNA binding	7536752.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	11146555.14654789.16494870.20890285.21397192.24413532.24531343.	IPI	Function
GO:0005634	nucleus	7536752.19158679.24413532.24531343.	IDA	Component
GO:0005654	nucleoplasm	14654789.	IDA	Component
GO:0005730	nucleolus	14654789.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	24531343.	IPI	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006914	autophagy	-	IEA	Process
GO:0006954	inflammatory response	-	IEA	Process
GO:0008134	transcription factor binding	12894224.22291595.	IDA	Function
GO:0008283	cell proliferation	9766636.	NAS	Process
GO:0010506	regulation of autophagy	21573174.	IEP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	19158679.	IDA	Component
GO:0030097	hemopoiesis	9766636.	NAS	Process
GO:0030099	myeloid cell differentiation	7536752.	NAS	Process
GO:0030224	monocyte differentiation	9766636.	IDA	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032731	positive regulation of interleukin-1 beta production	21575908.	IDA	Process
GO:0035458	cellular response to interferon-beta	-	IEA	Process
GO:0040029	regulation of gene expression, epigenetic	24413532.	IMP	Process
GO:0042149	cellular response to glucose starvation	21573174.	IDA	Process
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	14654789.	IDA	Process
GO:0043392	negative regulation of DNA binding	22291595.	IDA	Process
GO:0045071	negative regulation of viral genome replication	22291595.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045824	negative regulation of innate immune response	22046441.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	9642285.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	11146555.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21575908.	IMP	Process
GO:0051607	defense response to virus	21478870.	IDA	Process
GO:0051607	defense response to virus	21575908.	IMP	Process
GO:0071479	cellular response to ionizing radiation	14654789.	IDA	Process
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	21573174.	IMP	Process
GO:0097202	activation of cysteine-type endopeptidase activity	21575908.	IMP	Process
GO:2000117	negative regulation of cysteine-type endopeptidase activity	22046441.	IDA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.