EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18607064	Molecular detection of neuron-specific ELAV-like-positive cells in the peripheral blood of patients with small-cell lung cancer.	Cell Oncol	2008	D'Alessandro V	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	50193912	Missense_Mutation	novel	V168F	0.41
ACC	chr1	50201183	3'UTR	novel		0.95
ACC	chr1	50145145	Silent	rs754162796	F66F	0.4
ACC	chr1	50193816	Missense_Mutation	novel	V136F	0.25
BLCA	chr1	50200925	Missense_Mutation	novel	W297S	0.22
BLCA	chr1	50200986	Silent	NA	F317F	0.2
BLCA	chr1	50145094	Silent	NA	I49I	0.18
BLCA	chr1	50200835	Missense_Mutation	NA	S267F	0.22
BLCA	chr1	50201132	Missense_Mutation	novel	R366T	0.65	RRM_5
BLCA	chr1	50177098	Nonsense_Mutation	NA	L87*	0.13
BLCA	chr1	50200927	Missense_Mutation	novel	C298R	0.05
BLCA	chr1	50109156	5'UTR	novel		0.1
BLCA	chr1	50145140	Missense_Mutation	NA	L65F	0.14
BLCA	chr1	50103969	5'Flank	novel		0.13
BLCA	chr1	50195593	Missense_Mutation	novel	D181H	0.31
BLCA	chr1	50177146	Missense_Mutation	NA	A103V	0.29
BLCA	chr1	50197432	Frame_Shift_Ins	novel	*L250Tfs10**	0.19
BLCA	chr1	50195611	Missense_Mutation	NA	E187K	0.28
BRCA	chr1	50106387	5'Flank	NA		0.29
BRCA	chr1	50201473	3'Flank	novel		0.63
BRCA	chr1	50195598	Missense_Mutation	NA	K182N	0.1
BRCA	chr1	50109843	Intron	novel		0.19
BRCA	chr1	50145145	Silent	rs754162796	F66F	0.1
BRCA	chr1	50201055	Silent	rs764075721	F340F	0.33
CESC	chr1	50195588	Missense_Mutation	NA	R179H	0.22
CESC	chr1	50195588	Missense_Mutation	NA	R179H	0.1
CESC	chr1	50195778	Missense_Mutation	novel	Q242H	0.24
CESC	chr1	50193868	Missense_Mutation	NA	S153L	0.26
CESC	chr1	50193829	Missense_Mutation	novel	P140L	0.35
CESC	chr1	50109136	5'UTR	novel		0.23
CHOL	chr1	50201239	3'UTR	novel		0.06
COAD	chr1	50195575	Missense_Mutation	novel	V175M	0.21
COAD	chr1	50200934	Missense_Mutation	NA	F300S	0.37
COAD	chr1	50197459	Silent	rs761380670	G255G	0.31
COAD	chr1	50201224	3'UTR	novel		0.42
COAD	chr1	50201023	Missense_Mutation	NA	R330C	0.33	RRM_5
COAD	chr1	50200959	Silent	rs138724011	S308S	0.31
COAD	chr1	50201113	Missense_Mutation	NA	G360R	0.28	RRM_5
COAD	chr1	50201089	Missense_Mutation	novel	A352T	0.07	RRM_5
COAD	chr1	50144975	Missense_Mutation	novel	P10T	0.15
COAD	chr1	50200808	Splice_Site	NA	X258_splice	0.27
COAD	chr1	50201198	3'UTR	novel		0.1
COAD	chr1	50106346	5'Flank	novel		0.1
COAD	chr1	50195583	Missense_Mutation	NA	F177L	0.38
COAD	chr1	50201023	Missense_Mutation	NA	R330C	0.39	RRM_5
COAD	chr1	50195744	Missense_Mutation	NA	R231Q	0.35
COAD	chr1	50145053	Nonsense_Mutation	NA	Q36*	0.31
COAD	chr1	50106376	5'Flank	novel		0.38
COAD	chr1	50193782	Silent	rs528644967	P124P	0.41
COAD	chr1	50106377	5'Flank	novel		0.08
COAD	chr1	50197434	Missense_Mutation	novel	D247G	0.08
DLBC	chr1	50109156	5'UTR	novel		0.59
ESCA	chr1	50195646	Silent	novel	P198P	0.09
ESCA	chr1	50197548	Intron	novel		0.54
ESCA	chr1	50145144	Missense_Mutation	novel	F66C	0.07
ESCA	chr1	50106376	5'Flank	novel		0.16
ESCA	chr1	50201238	3'UTR	novel		0.26
GBM	chr1	50145095	Missense_Mutation	rs116391279	V50I	0.23
GBM	chr1	50193888	Missense_Mutation	novel	T160A	0.19
GBM	chr1	50200864	Missense_Mutation	novel	T277P	0.08
GBM	chr1	50195684	Missense_Mutation	NA	N211I	0.28
HNSC	chr1	50197511	Intron	novel		0.08
HNSC	chr1	50109156	5'UTR	novel		0.09
HNSC	chr1	50145030	Missense_Mutation	novel	N28S	0.34
HNSC	chr1	50109188	5'UTR	novel		0.17
HNSC	chr1	50197560	Intron	novel		0.26
HNSC	chr1	50195680	Missense_Mutation	novel	A210S	0.36
HNSC	chr1	50201024	Missense_Mutation	NA	R330H	0.14	RRM_5
HNSC	chr1	50109125	5'UTR	novel		0.58
HNSC	chr1	50177102	Silent	rs766623314	G88G	0.33
HNSC	chr1	50193781	Missense_Mutation	novel	P124L	0.14
HNSC	chr1	50201124	Silent	novel	L363L	0.33
HNSC	chr1	50197450	Missense_Mutation	novel	M252I	0.33
HNSC	chr1	50195646	Frame_Shift_Ins	novel	*S199Kfs53**	0.61
HNSC	chr1	50193882	In_Frame_Del	novel	I159_I163del	0.13
HNSC	chr1	50193822	Missense_Mutation	rs199932597	G138S	0.43
KICH	chr1	50193879	Missense_Mutation	rs138779266	R157C	0.08
KIRC	chr1	50145187	Missense_Mutation	novel	D80E	0.05
LGG	chr1	50177132	Missense_Mutation	novel	K98N	0.11
LIHC	chr1	50048150	5'UTR	novel		0.5
LIHC	chr1	50106353	5'Flank	novel		0.51
LUAD	chr1	50201169	Missense_Mutation	NA	H378Q	0.29	RRM_5
LUAD	chr1	50145128	Nonsense_Mutation	novel	E61*	0.13
LUAD	chr1	50193828	Frame_Shift_Del	novel	*T142Pfs2**	0.18
LUAD	chr1	50106353	5'Flank	novel		0.47
LUAD	chr1	50201010	Silent	rs769519214	N325N	0.1
LUAD	chr1	50200858	Missense_Mutation	novel	P275T	0.13
LUAD	chr1	50200859	Missense_Mutation	novel	P275Q	0.13
LUAD	chr1	50145109	Silent	novel	P54P	0.33
LUAD	chr1	50145000	Missense_Mutation	novel	S18Y	0.13
LUAD	chr1	50145001	Silent	novel	S18S	0.14
LUAD	chr1	50195586	Silent	novel	I178I	0.44
LUAD	chr1	50145066	Missense_Mutation	NA	T40N	0.18
LUAD	chr1	50197516	Intron	NA		0.27
LUAD	chr1	50193892	Nonsense_Mutation	novel	S161*	0.45
LUAD	chr1	50145084	Missense_Mutation	NA	T46I	0.25
LUAD	chr1	50109104	5'UTR	novel		0.55
LUAD	chr1	50200837	Missense_Mutation	NA	A268S	0.15
LUAD	chr1	50193825	Missense_Mutation	novel	L139I	0.17
LUAD	chr1	50195657	Missense_Mutation	novel	T202K	0.23
LUSC	chr1	50145128	Nonsense_Mutation	novel	E61*	0.42
LUSC	chr1	50193900	Silent	novel	L164L	0.4
LUSC	chr1	50145142	Silent	novel	L65L	0.2
LUSC	chr1	50197521	Intron	novel		0.15
LUSC	chr1	50200959	Silent	rs138724011	S308S	0.09
LUSC	chr1	50193880	Missense_Mutation	rs200396874	R157H	0.21
LUSC	chr1	50177153	Silent	novel	N105N	0.13
LUSC	chr1	50106390	5'Flank	novel		0.13
LUSC	chr1	50197511	Intron	novel		0.34
LUSC	chr1	50195593	Missense_Mutation	NA	D181N	0.38
LUSC	chr1	50177127	Missense_Mutation	NA	P97A	0.18
LUSC	chr1	50195746	Missense_Mutation	rs763739803	R232C	0.21
LUSC	chr1	50195747	Missense_Mutation	rs761620230	R232L	0.21
LUSC	chr1	50103989	5'Flank	novel		0.57
LUSC	chr1	50201073	Silent	novel	T346T	0.36
LUSC	chr1	50200952	Missense_Mutation	novel	P306H	0.58
LUSC	chr1	50145184	Missense_Mutation	novel	R79S	0.14
LUSC	chr1	50195586	Silent	novel	I178I	0.36
LUSC	chr1	50177155	Missense_Mutation	novel	T106N	0.11
OV	chr1	50201026	Missense_Mutation	novel	D331Y	0.05	RRM_5
OV	chr1	50201028	Frame_Shift_Del	novel	*F332Sfs14**	0.04	RRM_5
OV	chr1	50197558	Intron	novel		0.15
OV	chr1	50200914	Silent	novel	T293T	0.24
OV	chr1	50195733	Silent	novel	Q227Q	0.09
PAAD	chr1	50109165	5'UTR	novel		0.29
PAAD	chr1	50197430	Missense_Mutation	novel	L246M	0.09
PRAD	chr1	50177155	Missense_Mutation	rs758825213	T106I	0.3
READ	chr1	50201175	Silent	NA	S380S	0.44
READ	chr1	50201087	Missense_Mutation	NA	A351V	0.26	RRM_5
SARC	chr1	50109964	Intron	novel		0.28
SKCM	chr1	50145156	Missense_Mutation	NA	G70D	0.12
SKCM	chr1	50145135	Missense_Mutation	novel	R63K	0.05
SKCM	chr1	50145136	Silent	novel	R63R	0.05
SKCM	chr1	50106355	5'Flank	novel		0.33
SKCM	chr1	50177106	Missense_Mutation	novel	G90R	0.24
SKCM	chr1	50201028	Frame_Shift_Del	novel	*F332Sfs14**	0.68	RRM_5
SKCM	chr1	50201147	Missense_Mutation	NA	S371F	0.23	RRM_5
SKCM	chr1	50145018	Missense_Mutation	novel	P24L	0.31
SKCM	chr1	50193895	Missense_Mutation	NA	R162Q	0.25
SKCM	chr1	50201113	Missense_Mutation	NA	G360R	0.63	RRM_5
SKCM	chr1	50201183	3'UTR	novel		0.54
SKCM	chr1	50201049	Silent	novel	K338K	0.29
SKCM	chr1	50177143	Missense_Mutation	novel	K102T	0.4
SKCM	chr1	50195737	Missense_Mutation	NA	P229S	0.13
SKCM	chr1	50195744	Missense_Mutation	NA	R231Q	0.5
SKCM	chr1	50145148	Silent	NA	G67G	0.37
SKCM	chr1	50200870	Missense_Mutation	novel	D279N	0.49
SKCM	chr1	50177163	Missense_Mutation	novel	G109R	0.32
SKCM	chr1	50193782	Silent	rs528644967	P124P	0.43
SKCM	chr1	50201023	Missense_Mutation	NA	R330C	0.29	RRM_5
SKCM	chr1	50201066	Missense_Mutation	NA	T344I	0.16	RRM_5
SKCM	chr1	50200932	Silent	novel	I299I	0.4
SKCM	chr1	50106394	5'Flank	novel		0.29
SKCM	chr1	50195573	Missense_Mutation	NA	G174E	0.28
SKCM	chr1	50109961	Intron	novel		0.36
SKCM	chr1	50145164	Missense_Mutation	NA	E73K	0.9
SKCM	chr1	50201137	Silent	novel	L368L	0.53
SKCM	chr1	50193853	Missense_Mutation	NA	L148P	0.27
SKCM	chr1	50195659	Missense_Mutation	NA	E203K	0.09
SKCM	chr1	50145125	Missense_Mutation	NA	E60K	0.96
SKCM	chr1	50193895	Missense_Mutation	NA	R162Q	0.42
SKCM	chr1	50145014	Missense_Mutation	NA	G23R	0.41
SKCM	chr1	50195682	Silent	novel	A210A	0.41
SKCM	chr1	50200856	Missense_Mutation	novel	S274F	0.39
SKCM	chr1	50109077	5'UTR	novel		0.23
SKCM	chr1	50193854	Silent	NA	L148L	0.14
STAD	chr1	50193874	Missense_Mutation	NA	Y155C	0.04
STAD	chr1	50200850	Missense_Mutation	novel	R272K	0.41
STAD	chr1	50109165	5'UTR	novel		0.41
STAD	chr1	50193822	Missense_Mutation	novel	G138C	0.15
STAD	chr1	50201201	3'UTR	novel		0.31
STAD	chr1	50193782	Silent	rs528644967	P124P	0.38
STAD	chr1	50201120	Missense_Mutation	rs377132231	R362H	0.33	RRM_5
STAD	chr1	50193821	Silent	rs374149997	S137S	0.22
STAD	chr1	50193822	Missense_Mutation	rs199932597	G138S	0.27
STAD	chr1	50145010	Silent	NA	S21S	0.35
STAD	chr1	50195587	Missense_Mutation	NA	R179C	0.24
STAD	chr1	50144974	Missense_Mutation	NA	E9D	0.28
STAD	chr1	50177155	Missense_Mutation	NA	T106S	0.46
STAD	chr1	50193888	Missense_Mutation	novel	T160A	0.38
STAD	chr1	50201024	Missense_Mutation	NA	R330H	0.12	RRM_5
TGCT	chr1	50201239	3'UTR	novel		0.08
UCEC	chr1	50103979	5'Flank	novel		0.34
UCEC	chr1	50106363	5'Flank	NA		0.32
UCEC	chr1	50109131	5'UTR	novel		0.23
UCEC	chr1	50109131	5'UTR	novel		0.36
UCEC	chr1	50106337	5'Flank	novel		0.45
UCEC	chr1	50193868	Missense_Mutation	NA	S153L	0.56
UCEC	chr1	50145176	Missense_Mutation	novel	L77F	0.35
UCEC	chr1	50193825	Missense_Mutation	novel	L139I	0.31
UCEC	chr1	50197489	Intron	novel		0.39
UCEC	chr1	50195563	Missense_Mutation	NA	V171M	0.22
UCEC	chr1	50193810	Missense_Mutation	NA	L134F	0.26
UCEC	chr1	50109073	5'UTR	novel		0.19
UCEC	chr1	50193862	Missense_Mutation	novel	L151R	0.08
UCEC	chr1	50177179	Missense_Mutation	novel	T114I	0.13
UCEC	chr1	50106381	5'Flank	novel		0.41
UCEC	chr1	50109195	Silent	novel	V2V	0.27
UCEC	chr1	50197490	Intron	novel		0.35
UCEC	chr1	50106383	5'Flank	novel		0.07
UCEC	chr1	50109142	5'UTR	novel		0.42
UCEC	chr1	50145145	Silent	rs754162796	F66F	0.24
UCEC	chr1	50109839	Intron	novel		0.33
UCEC	chr1	50201473	3'Flank	novel		0.33
UCEC	chr1	50201177	Nonstop_Mutation	NA	381Lext11	0.09
UCEC	chr1	50109081	5'UTR	novel		0.46
UCEC	chr1	50200868	Missense_Mutation	rs765189019	I278T	0.43
UCEC	chr1	50201253	3'UTR	novel		0.25
UCEC	chr1	50193782	Silent	rs528644967	P124P	0.54
UCEC	chr1	50109102	5'UTR	novel		0.13
UCEC	chr1	50109165	5'UTR	novel		0.34
UCEC	chr1	50193767	Splice_Region	novel	V119V	0.27
UCEC	chr1	50193874	Missense_Mutation	NA	Y155C	0.08
UCEC	chr1	50200945	Missense_Mutation	novel	L304M	0.2
UCEC	chr1	50201164	Missense_Mutation	novel	A377T	0.33	RRM_5
UCEC	chr1	50103964	5'Flank	novel		0.36
UCEC	chr1	50200984	Missense_Mutation	novel	F317V	0.09
UCEC	chr1	50201221	3'UTR	rs202015947		0.25
UCEC	chr1	50201055	Silent	rs764075721	F340F	0.21
UCEC	chr1	50193836	Silent	novel	T142T	0.28
UCEC	chr1	50201235	3'UTR	novel		0.25
UCEC	chr1	50144979	Missense_Mutation	novel	Q11R	0.29
UCEC	chr1	50109131	5'UTR	novel		0.21
UCEC	chr1	50195677	Missense_Mutation	NA	F209V	0.44
UCEC	chr1	50201264	3'UTR	novel		0.25
UCEC	chr1	50177166	Missense_Mutation	novel	L110I	0.36
UCEC	chr1	50201010	Silent	rs769519214	N325N	0.58
UCEC	chr1	50201235	3'UTR	novel		0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
THYM	0.039	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
ACC	0.0078	Kaplan-Meier Survival Analysis
SKCM	0.00066	Kaplan-Meier Survival Analysis
PAAD	0.0034	Kaplan-Meier Survival Analysis
BLCA	0.039	Kaplan-Meier Survival Analysis
CESC	0.01	Kaplan-Meier Survival Analysis
LIHC	0.012	Kaplan-Meier Survival Analysis
LGG	0.00019	Kaplan-Meier Survival Analysis
LUAD	0.005	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000162374 (Gene tree)
Gene ID: 1996
Gene Symbol: ELAVL4
Alias: PNEM|HUD
Full Name: ELAV like RNA binding protein 4
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 155,773 bases
Position: chr1:50,048,014-50,203,786
Accession: 3315
Summary: (ELAV Like RNA Binding Protein 4) is a Protein Coding gene. Diseases associated with ELAVL4 include Hallucinogen Abuse and Sensory Peripheral Neuropathy. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ELAVL2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000360889	RRM_5	PF13893.6	7.3e-13	1	2
ENSP00000360889	RRM_5	PF13893.6	7.3e-13	2	2
ENSP00000360892	RRM_5	PF13893.6	7.5e-13	1	2
ENSP00000360892	RRM_5	PF13893.6	7.5e-13	2	2
ENSP00000399939	RRM_5	PF13893.6	7.8e-13	1	2
ENSP00000399939	RRM_5	PF13893.6	7.8e-13	2	2
ENSP00000360884	RRM_5	PF13893.6	8e-13	1	2
ENSP00000360884	RRM_5	PF13893.6	8e-13	2	2
ENSP00000360888	RRM_5	PF13893.6	8.4e-13	1	2
ENSP00000360888	RRM_5	PF13893.6	8.4e-13	2	2
ENSP00000360886	RRM_5	PF13893.6	9.2e-13	1	2
ENSP00000360886	RRM_5	PF13893.6	9.2e-13	2	2
ENSP00000349594	RRM_5	PF13893.6	1.2e-12	1	2
ENSP00000349594	RRM_5	PF13893.6	1.2e-12	2	2
ENSP00000360892	RRM_1	PF00076.22	5e-65	1	3
ENSP00000360892	RRM_1	PF00076.22	5e-65	2	3
ENSP00000360892	RRM_1	PF00076.22	5e-65	3	3
ENSP00000360889	RRM_1	PF00076.22	5e-65	1	3
ENSP00000360889	RRM_1	PF00076.22	5e-65	2	3
ENSP00000360889	RRM_1	PF00076.22	5e-65	3	3
ENSP00000399939	RRM_1	PF00076.22	5.2e-65	1	3
ENSP00000399939	RRM_1	PF00076.22	5.2e-65	2	3
ENSP00000399939	RRM_1	PF00076.22	5.2e-65	3	3
ENSP00000360884	RRM_1	PF00076.22	5.2e-65	1	3
ENSP00000360884	RRM_1	PF00076.22	5.2e-65	2	3
ENSP00000360884	RRM_1	PF00076.22	5.2e-65	3	3
ENSP00000360888	RRM_1	PF00076.22	6e-65	1	3
ENSP00000360888	RRM_1	PF00076.22	6e-65	2	3
ENSP00000360888	RRM_1	PF00076.22	6e-65	3	3
ENSP00000360886	RRM_1	PF00076.22	6.3e-65	1	3
ENSP00000360886	RRM_1	PF00076.22	6.3e-65	2	3
ENSP00000360886	RRM_1	PF00076.22	6.3e-65	3	3
ENSP00000349594	RRM_1	PF00076.22	7.7e-65	1	3
ENSP00000349594	RRM_1	PF00076.22	7.7e-65	2	3
ENSP00000349594	RRM_1	PF00076.22	7.7e-65	3	3

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11711535	HuD, a neuronal-specific RNA-binding protein, increases the in vivo stability of MYCN RNA.	J Biol Chem	2002 Jan 18	Manohar CF	-
10848602	HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.	Mol Cell Biol	2000 Jul	Park S	-
9045688	The Elav-like proteins bind to a conserved regulatory element in the 3'-untranslated region of GAP-43 mRNA.	J Biol Chem	1997 Mar 7	Chung S	-
11573004	Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins.	Proc Natl Acad Sci U S A	2001 Sep 25	Quattrone A	-
21288476	Microtubule association of a neuronal RNA-binding protein HuD through its binding to the light chain of MAP1B.	Biochimie	2011 May	Fujiwara Y	doi: 10.1016/j.biochi.2011.01.008
24036060	Neuroserpin up-regulation in the Alzheimer's disease brain is associated with elevated thyroid hormone receptor--and-beta;1 and HuD expression.	Neurochem Int	2013 Nov	Subhadra B	doi: 10.1016/j.neuint.2013.08.010
28560387	Reciprocal antagonistic regulation of N-myc mRNA by miR17 and the neuronal-specific RNA-binding protein HuD.	Oncol Rep	2017 Jul	Samaraweera L	doi: 10.3892/or.2017.5664
7541976	Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites.	Ann Neurol	1995 Jul	Manley GT	-
9815574	Neuron-specific hel-N1 and HuD as novel molecular markers of neuroblastoma: a correlation of HuD messenger RNA levels with favorable prognostic features.	Clin Cancer Res	1997 Oct	Ball NS	-
9729424	Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system development.	Brain Res Dev Brain Res	1998 Aug 8	Clayton GH	-
1655278	HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.	Cell	1991 Oct 18	Szabo A	-
9516855	HuD, a neuronal-specific RNA-binding protein, is a potential regulator of MYCN expression in human neuroblastoma cells.	Eur J Cancer	1997 Oct	Ross RA	-
9524251	Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4.	Gene	1998 Feb 27	Inman MV	-
8982120	The HuD paraneoplastic protein shares immunogenic regions between PEM/PSN patients and several strains and species of experimental animals.	J Neuroimmunol	1996 Dec	Sillevis Smitt P	-
8619556	Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma.	Ann Neurol	1996 May	King PH	-
8053656	Autoantibodies against the Hel-N1 RNA-binding protein among patients with lung carcinoma: an association with type I anti-neuronal nuclear antibodies.	Ann Neurol	1994 Aug	Dropcho EJ	-
8036161	GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element.	Nucleic Acids Res	1994 Jun 25	Qian Z	-
16927307	The RNA-binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity.	Bioessays	2006 Aug	Deschenes-Furry J	-
12605686	The 3'-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR.	Eur J Biochem	2003 Jan	Wein G	-
12468554	Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD.	J Biol Chem	2003 Feb 21	Deschenes-Furry J	-
12384599	Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins.	Nucleic Acids Res	2002 Oct 15	Kasashima K	-
12034726	Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD.	J Biol Chem	2002 Aug 2	Beckel-Mitchener AC	-
12000840	HuD binds to three AU-rich sequences in the 3'-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein.	Nucleic Acids Res	2002 May 15	Cuadrado A	-
12006625	Ectopic expression of Drosophila ELAV and human HuD in Drosophila wing disc cells reveals functional distinctions and similarities.	J Cell Sci	2002 Jun 1	Toba G	-
11948657	Role of HuD and other RNA-binding proteins in neural development and plasticity.	J Neurosci Res	2002 Apr 15	Perrone-Bizzozero N	-
11259113	Overexpression of HuD accelerates neurite outgrowth and increases GAP-43 mRNA expression in cortical neurons and retinoic acid-induced embryonic stem cells in vitro.	Exp Neurol	2001 Apr	Anderson KD	-
10710437	RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay.	Nucleic Acids Res	2000 Apr 1	King PH	-
10620013	Cytoplasmic localization is required for the mammalian ELAV-like protein HuD to induce neuronal differentiation.	Genes Cells	1999 Nov	Kasashima K	-
16278682	Loss of one HuD allele on chromosome #1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells.	Oncogene	2006 Feb 2	Grandinetti KB	-
16242680	Role of ELAV-like RNA-binding proteins HuD and HuR in the post-transcriptional regulation of acetylcholinesterase in neurons and skeletal muscle cells.	Chem Biol Interact	2005 Dec 15	Deschenes-Furry J	-
15827745	Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease.	Hum Genet	2005 Jun	Noureddine MA	-
16801526	HuD distribution changes in response to heat shock but not neurotrophic stimulation.	J Histochem Cytochem	2006 Oct	Burry RW	-
15358174	TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.	Biochem Biophys Res Commun	2004 Aug 20	Saito K	-
14745023	Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory.	Proc Natl Acad Sci U S A	2004 Feb 3	Pascale A	-
20159993	Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members.	Nucleic Acids Res	2010 Jun	Wang H	doi: 10.1093/nar/gkq028
20064466	The ELAV protein HuD stimulates cap-dependent translation in a Poly(A)- and eIF4A-dependent manner.	Mol Cell	2009 Dec 25	Fukao A	doi: 10.1016/j.molcel.2009.11.013.
20047656	A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins.	BMC Bioinformatics	2010 Jan 4	Enstero M	doi: 10.1186/1471-2105-11-6.
19846595	Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets.	Nucleic Acids Res	2010 Jan	Bolognani F	doi: 10.1093/nar/gkp863
19014379	Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.	J Neurochem	2008 Dec	Tiruchinapalli DM	doi: 10.1111/j.1471-4159.2008.05718.x
18493953	Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD.	Hippocampus	2008	Tanner DC	doi: 10.1002/hipo.20442.
22895702	Characterization of multiple exon 1 variants in mammalian HuD mRNA and neuron-specific transcriptional control via neurogenin 2.	J Neurosci	2012 Aug 15	Bronicki LM	doi: 10.1523/JNEUROSCI.2247-12.2012.
17234598	The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy.	J Neurosci	2007 Jan 17	Deschenes-Furry J	-
17035636	A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators.	Mol Biol Cell	2006 Dec	Zhu H	-
23383270	HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA.	PLoS One	2013	Allen M	doi: 10.1371/journal.pone.0055718
22075994	Functional and direct interaction between the RNA binding protein HuD and active Akt1.	Nucleic Acids Res	2012 Mar	Fujiwara T	doi: 10.1093/nar/gkr979
22004431	Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice.	ASN Neuro	2011	Perrone-Bizzozero NI	doi: 10.1042/AN20110015.
21652774	Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits.	Proc Natl Acad Sci U S A	2011 Jun 21	Akten B	doi: 10.1073/pnas.1104928108
21088113	HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects.	Hum Mol Genet	2011 Feb 1	Hubers L	doi: 10.1093/hmg/ddq500
25692578	HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites.	PLoS One	2015 Feb 18	Vanevski F	doi: 10.1371/journal.pone.0117264
24857657	HuD regulates coding and noncoding RNA to induce APP-A-and-beta; processing.	Cell Rep	2014 Jun 12	Kang MJ	doi: 10.1016/j.celrep.2014.04.050
24658850	RNA-binding proteins in neurological diseases.	Sci China Life Sci	2014 Apr	Zhou H	-
24599466	Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior.	J Neurosci	2014 Mar 5	DeBoer EM	doi: 10.1523/JNEUROSCI.3703-13.2014.
23836929	Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.	J Cell Biol	2013 Jul 8	Sosanya NM	doi: 10.1083/jcb.201212089.
25818007	Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy.	Neurobiol Dis	2015 Jun	Winden KD	doi: 10.1016/j.nbd.2015.02.011
26305964	Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis.	Proc Natl Acad Sci U S A	2015 Sep 8	Wang F	doi: 10.1073/pnas.1513780112
25944900	Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II -and-alpha; (CaMKII-and-alpha;) mRNAs by the RNA-binding Protein HuD.	J Biol Chem	2015 Jun 26	Sosanya NM	doi: 10.1074/jbc.M114.599399
28739747	Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.	Anticancer Res	2017 Aug	Wang F	-
28988989	FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis.	Stem Cell Reports	2017 Nov 14	De Santis R	doi: 10.1016/j.stemcr.2017.09.004
29061699	HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.	J Neurosci	2017 Nov 29	Hao le T	doi: 10.1523/JNEUROSCI.1528-17.2017
29614249	Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG.	Neurosci Res	2018 Oct	Ogawa Y	doi: 10.1016/j.neures.2018.03.008
30014466	Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis.	J Pathol	2018 Oct	Kim C	doi: 10.1002/path.5135
30028999	A Translation Tuning HuDdle for Neurons.	Mol Cell	2018 Jul 19	McMahon M	doi: 10.1016/j.molcel.2018.07.007.
30029004	HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA.	Mol Cell	2018 Jul 19	Tebaldi T	doi: 10.1016/j.molcel.2018.06.032.
30377250	Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD.	J Biol Chem	2018 Dec 21	Gong Q	doi: 10.1074/jbc.RA118.003720
31013625	RNA-Binding Proteins HuB, HuC, and HuD are Distinctly Regulated in Dorsal Root Ganglia Neurons from STZ-Sensitive Compared to STZ-Resistant Diabetic Mice.	Int J Mol Sci	2019 Apr 22	Mustaciosu CC	doi: 10.3390/ijms20081965.
9685407	p21(waf1) mRNA contains a conserved element in its 3'-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins.	J Biol Chem	1998 Aug 7	Joseph B	-
20508147	Signatures of RNA binding proteins globally coupled to effective microRNA target sites.	Genome Res	2010 Aug	Jacobsen A	doi: 10.1101/gr.103259.109

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000492299	ELAVL4-210	2106	-	-	- (aa)	-	-
ENST00000371819	ELAVL4-202	2467	-	ENSP00000360884	371 (aa)	-	B1APY9
ENST00000371821	ELAVL4-203	3349	XM_006710411	ENSP00000360886	385 (aa)	XP_006710474	B1APY8
ENST00000357083	ELAVL4-201	1442	XM_011540889	ENSP00000349594	402 (aa)	XP_011539191	A0A0R4J2E6
ENST00000463650	ELAVL4-208	489	-	-	- (aa)	-	-
ENST00000474675	ELAVL4-209	600	-	-	- (aa)	-	-
ENST00000371823	ELAVL4-204	1591	XM_011540895	ENSP00000360888	380 (aa)	XP_011539197	P26378
ENST00000371824	ELAVL4-205	3966	XM_024453829	ENSP00000360889	366 (aa)	XP_024309597	P26378
ENST00000448907	ELAVL4-207	1951	-	ENSP00000399939	369 (aa)	-	P26378
ENST00000371827	ELAVL4-206	3775	XM_011540893	ENSP00000360892	366 (aa)	XP_011539195	P26378
ENST00000494555	ELAVL4-211	458	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000162374	Anthropometry	8.5960000E-005	-
ENSG00000162374	Creatinine	7.7010000E-005	-
ENSG00000162374	Platelet Function Tests	4.0056500E-005	-
ENSG00000162374	Platelet Function Tests	9.0948907E-006	-
ENSG00000162374	Insulin-Like Growth Factor Binding Proteins	6E-6	23251661
ENSG00000162374	Body Mass Index	1E-8	25673413
ENSG00000162374	Schizophrenia	6E-6	26198764
ENSG00000162374	Body Mass Index	6E-9	25673413

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000162374	rs12138061	1	50106424	A	Schizophrenia	26198764	[NR]	1.06	EFO_0000692
ENSG00000162374	rs12092053	1	50141357	C	Obesity-related traits	23251661	[NR] ng/mL increase	0.02	EFO_0005118
ENSG00000162374	rs12138061	1	50106424	A	Schizophrenia	28991256	[1.04-1.08]	1.057	EFO_0000692
ENSG00000162374	rs11583200	1	50094148	T	BMI (adjusted for smoking behaviour)	28443625	[0.013-0.031] kg/m2 decrease	0.0222	EFO_0004318\|EFO_0004340
ENSG00000162374	rs11583200	1	50094148	T	BMI (adjusted for smoking behaviour)	28443625	[0.0094-0.0228] kg/m2 decrease	0.0161	EFO_0004318\|EFO_0004340
ENSG00000162374	rs11583200	1	50094148	T	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000162374	rs11583200	1	50094148	T	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000162374	rs11583200	1	50094148	T	Body mass index	26426971	unit decrease	0.015170207	EFO_0004340
ENSG00000162374	rs6685278	1	50078144	?	Reaction time	29844566	[0.006-0.0129] unit increase	0.0094725	EFO_0008393
ENSG00000162374	rs11583200	1	50094148	C	Body mass index	30108127	[NR] unit increase	0.019	EFO_0004340
ENSG00000162374	rs11583200	1	50094148	C	Body mass index	26961502	[0.011-0.027] unit increase	0.019	EFO_0004340
ENSG00000162374	rs12022778	1	50138323	A	Smoking status (ever vs never smokers)	30643258	[0.011-0.021] unit decrease	0.015913688	EFO_0004318
ENSG00000162374	rs9436888	1	50113565	C	Age of smoking initiation (MTAG)	30643251	[0.0095-0.0163] unit decrease	0.0129134	EFO_0005670
ENSG00000162374	rs12733544	1	50097141	A	Cigarettes smoked per day (MTAG)	30643251	[0.011-0.02] unit increase	0.0152603	EFO_0006525
ENSG00000162374	rs7515768	1	50122210	T	Smoking cessation (MTAG)	30643251	[0.0076-0.0148] unit increase	0.0112335	EFO_0004319
ENSG00000162374	rs11579246	1	50093490	A	Depression	30718901	[1.025-1.04]	1.033	EFO_0003761
ENSG00000162374	rs12138061	1	50106424	A	Schizophrenia	30285260	[1.04-1.08]	1.059	EFO_0000692
ENSG00000162374	rs12022778	1	50138323	C	Smoking initiation (ever regular vs never regular)	30643251	[0.021-0.033] unit increase	0.0268248	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162374's network

Paralog

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000162374	ELAVL4	88	41.429	ENSG00000101104	PABPC1L	96	41.429
ENSG00000162374	ELAVL4	88	35.897	ENSG00000151923	TIAL1	91	36.620
ENSG00000162374	ELAVL4	66	34.118	ENSG00000213516	RBMXL1	53	34.118
ENSG00000162374	ELAVL4	64	38.333	ENSG00000144642	RBMS3	77	38.333
ENSG00000162374	ELAVL4	99	81.694	ENSG00000196361	ELAVL3	99	81.967
ENSG00000162374	ELAVL4	62	35.821	ENSG00000164548	TRA2A	60	31.068
ENSG00000162374	ELAVL4	57	39.726	ENSG00000101489	CELF4	89	30.097
ENSG00000162374	ELAVL4	68	38.889	ENSG00000099622	CIRBP	96	38.889
ENSG00000162374	ELAVL4	90	70.997	ENSG00000066044	ELAVL1	97	72.222
ENSG00000162374	ELAVL4	89	40.541	ENSG00000131051	RBM39	74	40.541
ENSG00000162374	ELAVL4	88	31.579	ENSG00000151846	PABPC3	63	31.579
ENSG00000162374	ELAVL4	99	89.071	ENSG00000107105	ELAVL2	100	94.444
ENSG00000162374	ELAVL4	64	36.111	ENSG00000153250	RBMS1	90	36.111
ENSG00000162374	ELAVL4	94	35.897	ENSG00000116001	TIA1	86	35.897
ENSG00000162374	ELAVL4	81	38.272	ENSG00000048740	CELF2	59	38.272
ENSG00000162374	ELAVL4	88	36.145	ENSG00000070756	PABPC1	95	40.323
ENSG00000162374	ELAVL4	65	34.118	ENSG00000147274	RBMX	86	34.328
ENSG00000162374	ELAVL4	90	30.726	ENSG00000143368	SF3B4	74	35.294
ENSG00000162374	ELAVL4	93	40.741	ENSG00000140488	CELF6	97	35.802
ENSG00000162374	ELAVL4	76	40.741	ENSG00000149187	CELF1	94	31.461
ENSG00000162374	ELAVL4	71	40.741	ENSG00000159409	CELF3	61	40.741
ENSG00000162374	ELAVL4	90	35.135	ENSG00000100461	RBM23	63	35.135
ENSG00000162374	ELAVL4	87	30.921	ENSG00000090621	PABPC4	97	35.294

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162374	ELAVL4	99	93.989	ENSAPOG00000020329	elavl4	97	93.496	Acanthochromis_polyacanthus
ENSG00000162374	ELAVL4	100	99.740	ENSAMEG00000017455	ELAVL4	100	99.740	Ailuropoda_melanoleuca
ENSG00000162374	ELAVL4	98	94.460	ENSACIG00000008793	elavl4	100	94.460	Amphilophus_citrinellus
ENSG00000162374	ELAVL4	81	90.217	ENSAOCG00000022907	elavl4	89	90.217	Amphiprion_ocellaris
ENSG00000162374	ELAVL4	66	82.400	ENSAOCG00000022503	elavl4	70	82.540	Amphiprion_ocellaris
ENSG00000162374	ELAVL4	100	93.207	ENSAPEG00000022826	elavl4	95	93.207	Amphiprion_percula
ENSG00000162374	ELAVL4	100	93.478	ENSATEG00000006136	elavl4	99	94.262	Anabas_testudineus
ENSG00000162374	ELAVL4	100	95.288	ENSACAG00000004527	ELAVL4	100	95.288	Anolis_carolinensis
ENSG00000162374	ELAVL4	100	99.751	ENSANAG00000030598	ELAVL4	100	99.751	Aotus_nancymaae
ENSG00000162374	ELAVL4	99	93.496	ENSACLG00000002786	elavl4	97	93.011	Astatotilapia_calliptera
ENSG00000162374	ELAVL4	99	95.330	ENSAMXG00000000687	elavl4	97	94.823	Astyanax_mexicanus
ENSG00000162374	ELAVL4	100	99.730	ENSBTAG00000021046	ELAVL4	100	99.730	Bos_taurus
ENSG00000162374	ELAVL4	95	61.333	WBGene00001368	exc-7	70	62.385	Caenorhabditis_elegans
ENSG00000162374	ELAVL4	100	99.751	ENSCJAG00000013725	ELAVL4	100	99.751	Callithrix_jacchus
ENSG00000162374	ELAVL4	100	99.727	ENSCAFG00000003927	ELAVL4	100	99.727	Canis_familiaris
ENSG00000162374	ELAVL4	100	99.180	ENSCAFG00020013581	ELAVL4	100	98.756	Canis_lupus_dingo
ENSG00000162374	ELAVL4	100	99.730	ENSCHIG00000002038	ELAVL4	100	99.730	Capra_hircus
ENSG00000162374	ELAVL4	88	99.245	ENSTSYG00000004130	ELAVL4	94	99.200	Carlito_syrichta
ENSG00000162374	ELAVL4	98	71.309	ENSCAPG00000011942	-	99	71.309	Cavia_aperea
ENSG00000162374	ELAVL4	76	100.000	ENSCAPG00000005993	ELAVL4	83	100.000	Cavia_aperea
ENSG00000162374	ELAVL4	100	99.740	ENSCPOG00000002044	-	100	99.740	Cavia_porcellus
ENSG00000162374	ELAVL4	98	70.166	ENSCPOG00000022816	-	99	70.166	Cavia_porcellus
ENSG00000162374	ELAVL4	100	99.751	ENSCCAG00000024797	ELAVL4	100	99.751	Cebus_capucinus
ENSG00000162374	ELAVL4	100	100.000	ENSCATG00000029867	ELAVL4	100	100.000	Cercocebus_atys
ENSG00000162374	ELAVL4	100	99.730	ENSCLAG00000005476	ELAVL4	100	99.739	Chinchilla_lanigera
ENSG00000162374	ELAVL4	100	100.000	ENSCSAG00000001257	ELAVL4	100	100.000	Chlorocebus_sabaeus
ENSG00000162374	ELAVL4	100	98.442	ENSCHOG00000002464	ELAVL4	100	98.442	Choloepus_hoffmanni
ENSG00000162374	ELAVL4	100	98.652	ENSCPBG00000010017	ELAVL4	100	98.652	Chrysemys_picta_bellii
ENSG00000162374	ELAVL4	92	43.548	ENSCING00000009052	-	100	43.548	Ciona_intestinalis
ENSG00000162374	ELAVL4	100	100.000	ENSCANG00000043683	ELAVL4	100	100.000	Colobus_angolensis_palliatus
ENSG00000162374	ELAVL4	100	99.740	ENSCGRG00001020348	Elavl4	100	99.740	Cricetulus_griseus_chok1gshd
ENSG00000162374	ELAVL4	100	99.740	ENSCGRG00000009162	Elavl4	100	99.740	Cricetulus_griseus_crigri
ENSG00000162374	ELAVL4	99	94.262	ENSCSEG00000020141	elavl4	97	93.767	Cynoglossus_semilaevis
ENSG00000162374	ELAVL4	99	93.750	ENSCVAG00000019080	elavl4	100	90.160	Cyprinodon_variegatus
ENSG00000162374	ELAVL4	99	95.879	ENSDARG00000045639	elavl4	91	95.109	Danio_rerio
ENSG00000162374	ELAVL4	100	99.730	ENSDNOG00000033502	ELAVL4	100	99.730	Dasypus_novemcinctus
ENSG00000162374	ELAVL4	100	99.740	ENSDORG00000012729	Elavl4	100	99.740	Dipodomys_ordii
ENSG00000162374	ELAVL4	99	92.838	ENSETEG00000013779	ELAVL4	100	92.838	Echinops_telfairi
ENSG00000162374	ELAVL4	100	99.461	ENSEASG00005010728	ELAVL4	100	99.461	Equus_asinus_asinus
ENSG00000162374	ELAVL4	100	99.461	ENSECAG00000022284	ELAVL4	100	99.461	Equus_caballus
ENSG00000162374	ELAVL4	100	99.481	ENSEEUG00000008766	ELAVL4	100	99.481	Erinaceus_europaeus
ENSG00000162374	ELAVL4	99	95.095	ENSELUG00000008025	elavl4	91	95.109	Esox_lucius
ENSG00000162374	ELAVL4	100	99.740	ENSFCAG00000010438	ELAVL4	100	99.740	Felis_catus
ENSG00000162374	ELAVL4	100	98.652	ENSFALG00000005331	ELAVL4	100	98.652	Ficedula_albicollis
ENSG00000162374	ELAVL4	100	99.730	ENSFDAG00000014507	ELAVL4	100	99.739	Fukomys_damarensis
ENSG00000162374	ELAVL4	100	94.022	ENSFHEG00000004530	elavl4	93	94.022	Fundulus_heteroclitus
ENSG00000162374	ELAVL4	98	95.822	ENSGMOG00000006515	elavl4	100	95.822	Gadus_morhua
ENSG00000162374	ELAVL4	100	98.652	ENSGALG00000010533	ELAVL4	100	98.652	Gallus_gallus
ENSG00000162374	ELAVL4	86	93.968	ENSGAFG00000015956	elavl4	84	93.671	Gambusia_affinis
ENSG00000162374	ELAVL4	98	93.629	ENSGACG00000011152	elavl4	100	93.629	Gasterosteus_aculeatus
ENSG00000162374	ELAVL4	99	98.626	ENSGAGG00000018269	ELAVL4	100	96.517	Gopherus_agassizii
ENSG00000162374	ELAVL4	100	100.000	ENSGGOG00000000634	ELAVL4	100	100.000	Gorilla_gorilla
ENSG00000162374	ELAVL4	99	94.262	ENSHBUG00000009691	elavl4	97	93.767	Haplochromis_burtoni
ENSG00000162374	ELAVL4	100	99.461	ENSHGLG00000000485	ELAVL4	100	99.464	Heterocephalus_glaber_female
ENSG00000162374	ELAVL4	100	99.461	ENSHGLG00100002567	ELAVL4	100	99.464	Heterocephalus_glaber_male
ENSG00000162374	ELAVL4	98	94.737	ENSHCOG00000002490	elavl4	100	94.737	Hippocampus_comes
ENSG00000162374	ELAVL4	99	95.604	ENSIPUG00000001381	elavl4	92	95.616	Ictalurus_punctatus
ENSG00000162374	ELAVL4	100	99.730	ENSSTOG00000027271	ELAVL4	100	99.730	Ictidomys_tridecemlineatus
ENSG00000162374	ELAVL4	100	99.727	ENSJJAG00000023099	Elavl4	100	99.739	Jaculus_jaculus
ENSG00000162374	ELAVL4	99	93.496	ENSKMAG00000022289	elavl4	93	93.514	Kryptolebias_marmoratus
ENSG00000162374	ELAVL4	99	93.767	ENSLBEG00000007096	elavl4	93	89.664	Labrus_bergylta
ENSG00000162374	ELAVL4	52	98.261	ENSLBEG00000015023	elavl4	100	98.261	Labrus_bergylta
ENSG00000162374	ELAVL4	100	97.561	ENSLACG00000008316	ELAVL4	100	97.561	Latimeria_chalumnae
ENSG00000162374	ELAVL4	99	96.154	ENSLOCG00000009363	elavl4	90	96.164	Lepisosteus_oculatus
ENSG00000162374	ELAVL4	100	99.740	ENSLAFG00000001087	ELAVL4	100	99.740	Loxodonta_africana
ENSG00000162374	ELAVL4	100	100.000	ENSMFAG00000039866	ELAVL4	100	100.000	Macaca_fascicularis
ENSG00000162374	ELAVL4	100	100.000	ENSMMUG00000021933	ELAVL4	100	100.000	Macaca_mulatta
ENSG00000162374	ELAVL4	100	99.751	ENSMNEG00000035576	ELAVL4	100	99.751	Macaca_nemestrina
ENSG00000162374	ELAVL4	100	100.000	ENSMLEG00000028616	ELAVL4	100	100.000	Mandrillus_leucophaeus
ENSG00000162374	ELAVL4	100	93.478	ENSMAMG00000004000	elavl4	100	93.478	Mastacembelus_armatus
ENSG00000162374	ELAVL4	99	94.262	ENSMZEG00005010690	elavl4	92	94.278	Maylandia_zebra
ENSG00000162374	ELAVL4	100	98.093	ENSMGAG00000010928	ELAVL4	100	97.312	Meleagris_gallopavo
ENSG00000162374	ELAVL4	100	99.740	ENSMAUG00000021566	Elavl4	100	99.740	Mesocricetus_auratus
ENSG00000162374	ELAVL4	100	100.000	ENSMICG00000003286	ELAVL4	100	100.000	Microcebus_murinus
ENSG00000162374	ELAVL4	100	99.737	ENSMOCG00000010309	Elavl4	100	99.739	Microtus_ochrogaster
ENSG00000162374	ELAVL4	100	93.478	ENSMMOG00000020264	elavl4	95	93.733	Mola_mola
ENSG00000162374	ELAVL4	96	64.000	ENSMODG00000003850	-	100	64.000	Monodelphis_domestica
ENSG00000162374	ELAVL4	94	97.561	ENSMODG00000001300	-	100	97.561	Monodelphis_domestica
ENSG00000162374	ELAVL4	99	93.989	ENSMALG00000016432	elavl4	97	93.496	Monopterus_albus
ENSG00000162374	ELAVL4	100	99.740	MGP_CAROLIEiJ_G0026289	Elavl4	100	99.740	Mus_caroli
ENSG00000162374	ELAVL4	100	99.740	ENSMUSG00000028546	Elavl4	100	99.740	Mus_musculus
ENSG00000162374	ELAVL4	100	99.740	MGP_PahariEiJ_G0028622	Elavl4	100	99.740	Mus_pahari
ENSG00000162374	ELAVL4	100	99.740	MGP_SPRETEiJ_G0027258	Elavl4	100	99.740	Mus_spretus
ENSG00000162374	ELAVL4	100	99.737	ENSMPUG00000007192	ELAVL4	100	99.737	Mustela_putorius_furo
ENSG00000162374	ELAVL4	100	98.907	ENSMLUG00000006226	ELAVL4	100	99.187	Myotis_lucifugus
ENSG00000162374	ELAVL4	100	99.474	ENSNGAG00000023123	Elavl4	100	99.474	Nannospalax_galili
ENSG00000162374	ELAVL4	100	100.000	ENSNLEG00000016303	ELAVL4	100	100.000	Nomascus_leucogenys
ENSG00000162374	ELAVL4	99	96.817	ENSMEUG00000007145	ELAVL4	100	96.817	Notamacropus_eugenii
ENSG00000162374	ELAVL4	100	99.740	ENSOPRG00000015300	ELAVL4	100	99.740	Ochotona_princeps
ENSG00000162374	ELAVL4	100	99.737	ENSODEG00000006770	ELAVL4	100	99.737	Octodon_degus
ENSG00000162374	ELAVL4	100	93.478	ENSONIG00000002360	elavl4	100	92.493	Oreochromis_niloticus
ENSG00000162374	ELAVL4	87	91.322	ENSOANG00000007377	ELAVL4	100	91.322	Ornithorhynchus_anatinus
ENSG00000162374	ELAVL4	99	99.725	ENSOCUG00000016262	ELAVL4	94	99.178	Oryctolagus_cuniculus
ENSG00000162374	ELAVL4	99	94.536	ENSORLG00000028487	elavl4	93	93.531	Oryzias_latipes
ENSG00000162374	ELAVL4	99	94.536	ENSORLG00020014277	elavl4	92	94.550	Oryzias_latipes_hni
ENSG00000162374	ELAVL4	99	94.536	ENSORLG00015010143	elavl4	92	94.550	Oryzias_latipes_hsok
ENSG00000162374	ELAVL4	99	93.989	ENSOMEG00000009988	elavl4	93	93.243	Oryzias_melastigma
ENSG00000162374	ELAVL4	100	99.180	ENSOGAG00000016990	ELAVL4	100	99.187	Otolemur_garnettii
ENSG00000162374	ELAVL4	100	99.730	ENSOARG00000004264	ELAVL4	100	99.730	Ovis_aries
ENSG00000162374	ELAVL4	100	100.000	ENSPPAG00000042402	ELAVL4	100	100.000	Pan_paniscus
ENSG00000162374	ELAVL4	100	99.740	ENSPPRG00000002764	ELAVL4	100	99.740	Panthera_pardus
ENSG00000162374	ELAVL4	100	99.740	ENSPTIG00000016727	ELAVL4	100	99.740	Panthera_tigris_altaica
ENSG00000162374	ELAVL4	100	100.000	ENSPTRG00000000723	ELAVL4	100	100.000	Pan_troglodytes
ENSG00000162374	ELAVL4	100	100.000	ENSPANG00000017754	ELAVL4	100	100.000	Papio_anubis
ENSG00000162374	ELAVL4	99	95.604	ENSPKIG00000006999	elavl4	98	95.068	Paramormyrops_kingsleyae
ENSG00000162374	ELAVL4	100	98.383	ENSPSIG00000008545	ELAVL4	100	98.383	Pelodiscus_sinensis
ENSG00000162374	ELAVL4	100	93.750	ENSPMGG00000022175	elavl4	100	93.750	Periophthalmus_magnuspinnatus
ENSG00000162374	ELAVL4	100	79.200	ENSPEMG00000021058	Elavl3	99	80.108	Peromyscus_maniculatus_bairdii
ENSG00000162374	ELAVL4	88	62.963	ENSPCIG00000017116	-	100	58.491	Phascolarctos_cinereus
ENSG00000162374	ELAVL4	99	94.536	ENSPFOG00000004811	elavl4	100	91.964	Poecilia_formosa
ENSG00000162374	ELAVL4	100	93.750	ENSPLAG00000008085	elavl4	99	94.521	Poecilia_latipinna
ENSG00000162374	ELAVL4	99	94.536	ENSPMEG00000015619	elavl4	90	94.550	Poecilia_mexicana
ENSG00000162374	ELAVL4	99	94.536	ENSPREG00000018937	elavl4	97	94.038	Poecilia_reticulata
ENSG00000162374	ELAVL4	100	99.730	ENSPPYG00000001367	ELAVL4	100	99.730	Pongo_abelii
ENSG00000162374	ELAVL4	100	99.740	ENSPCAG00000008215	ELAVL4	100	99.740	Procavia_capensis
ENSG00000162374	ELAVL4	100	100.000	ENSPCOG00000024957	ELAVL4	100	100.000	Propithecus_coquereli
ENSG00000162374	ELAVL4	88	98.855	ENSPVAG00000003632	ELAVL4	100	84.156	Pteropus_vampyrus
ENSG00000162374	ELAVL4	100	93.478	ENSPNYG00000021720	elavl4	100	93.750	Pundamilia_nyererei
ENSG00000162374	ELAVL4	99	95.330	ENSPNAG00000017169	elavl4	97	94.823	Pygocentrus_nattereri
ENSG00000162374	ELAVL4	100	99.740	ENSRNOG00000023601	Elavl4	100	99.740	Rattus_norvegicus
ENSG00000162374	ELAVL4	100	100.000	ENSRBIG00000043810	ELAVL4	100	100.000	Rhinopithecus_bieti
ENSG00000162374	ELAVL4	100	100.000	ENSRROG00000044786	ELAVL4	100	100.000	Rhinopithecus_roxellana
ENSG00000162374	ELAVL4	100	99.751	ENSSBOG00000022965	ELAVL4	100	99.751	Saimiri_boliviensis_boliviensis
ENSG00000162374	ELAVL4	94	63.953	ENSSHAG00000001657	-	94	63.953	Sarcophilus_harrisii
ENSG00000162374	ELAVL4	100	98.907	ENSSHAG00000013832	-	100	98.907	Sarcophilus_harrisii
ENSG00000162374	ELAVL4	99	95.604	ENSSFOG00015015838	elavl4	97	95.095	Scleropages_formosus
ENSG00000162374	ELAVL4	99	94.809	ENSSMAG00000006881	elavl4	97	93.548	Scophthalmus_maximus
ENSG00000162374	ELAVL4	99	94.262	ENSSDUG00000000045	elavl4	92	93.750	Seriola_dumerili
ENSG00000162374	ELAVL4	99	94.262	ENSSLDG00000005260	elavl4	92	94.278	Seriola_lalandi_dorsalis
ENSG00000162374	ELAVL4	99	99.735	ENSSARG00000010733	ELAVL4	100	99.735	Sorex_araneus
ENSG00000162374	ELAVL4	98	98.329	ENSSPUG00000011636	ELAVL4	100	98.329	Sphenodon_punctatus
ENSG00000162374	ELAVL4	100	93.478	ENSSPAG00000018867	elavl4	97	94.262	Stegastes_partitus
ENSG00000162374	ELAVL4	100	99.730	ENSSSCG00000037291	ELAVL4	100	99.730	Sus_scrofa
ENSG00000162374	ELAVL4	99	98.623	ENSTGUG00000008597	ELAVL4	100	98.623	Taeniopygia_guttata
ENSG00000162374	ELAVL4	98	94.183	ENSTRUG00000000523	elavl4	98	94.183	Takifugu_rubripes
ENSG00000162374	ELAVL4	100	93.207	ENSTNIG00000015485	elavl4	100	93.261	Tetraodon_nigroviridis
ENSG00000162374	ELAVL4	93	100.000	ENSTBEG00000011730	ELAVL4	80	100.000	Tupaia_belangeri
ENSG00000162374	ELAVL4	85	97.561	ENSTTRG00000012441	ELAVL4	67	97.561	Tursiops_truncatus
ENSG00000162374	ELAVL4	100	98.756	ENSUAMG00000013026	ELAVL4	100	99.725	Ursus_americanus
ENSG00000162374	ELAVL4	100	99.180	ENSUMAG00000023149	ELAVL4	100	99.735	Ursus_maritimus
ENSG00000162374	ELAVL4	100	99.740	ENSVPAG00000011606	ELAVL4	100	99.740	Vicugna_pacos
ENSG00000162374	ELAVL4	100	99.730	ENSVVUG00000006175	ELAVL4	100	99.730	Vulpes_vulpes
ENSG00000162374	ELAVL4	99	91.094	ENSXETG00000008680	elavl4	100	91.094	Xenopus_tropicalis
ENSG00000162374	ELAVL4	99	94.536	ENSXMAG00000025683	elavl4	97	94.038	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	1655278.	TAS	Function
GO:0003730	mRNA 3'-UTR binding	10848602.	TAS	Function
GO:0006396	RNA processing	1655278.	TAS	Process
GO:0006397	mRNA processing	10348344.	TAS	Process
GO:0017091	AU-rich element binding	10710437.	IDA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.