EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24358221	Upregulation of cleavage and polyadenylation specific factor 4 in lung adenocarcinoma and its critical role for cancer cell survival and proliferation.	PLoS One	2013 Dec 16	Chen W	doi: 10.1371/journal.pone.0082728

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr7	99454038	Nonsense_Mutation	novel	Q215*	0.25
BLCA	chr7	99456494	Silent	novel	G268G	0.15
BLCA	chr7	99454116	Missense_Mutation	novel	E241K	0.12
BLCA	chr7	99450729	Missense_Mutation	novel	R144Q	0.14
BLCA	chr7	99444832	Silent	rs759412959	C49C	0.47
BLCA	chr7	99452378	Missense_Mutation	NA	E170Q	0.25
BLCA	chr7	99450754	Silent	rs777553781	L152L	0.24
BRCA	chr7	99448262	Missense_Mutation	NA	Y99S	0.23
BRCA	chr7	99456488	Silent	novel	L266L	0.08
BRCA	chr7	99444833	Missense_Mutation	rs201226770	G50S	0.13
BRCA	chr7	99456453	Missense_Mutation	NA	A255T	0.79	zf-CCCH
BRCA	chr7	99452373	Missense_Mutation	rs200506342	R168Q	0.53
CESC	chr7	99457113	3'UTR	novel		0.32
CESC	chr7	99450326	Missense_Mutation	novel	K120Q	0.21
CESC	chr7	99439131	Missense_Mutation	NA	I17V	0.82
CESC	chr7	99456714	3'UTR	novel		0.33
CESC	chr7	99444805	Silent	rs772613412	V40V	0.26
CESC	chr7	99439122	Missense_Mutation	rs766880581	D14N	0.22
CESC	chr7	99439074	5'UTR	novel		0.41
CESC	chr7	99457280	3'UTR	novel		0.15
CESC	chr7	99454077	Nonsense_Mutation	NA	Q228*	0.35
CESC	chr7	99457049	3'UTR	novel		0.45
COAD	chr7	99444796	Silent	rs769057045	G37G	0.08
COAD	chr7	99456581	3'UTR	rs756757246		0.45
COAD	chr7	99448183	Missense_Mutation	NA	R73C	0.27
COAD	chr7	99456572	3'UTR	novel		0.47
COAD	chr7	99454040	Silent	novel	Q215Q	0.26
COAD	chr7	99456440	Silent	novel	E250E	0.18
COAD	chr7	99456452	Silent	rs755817381	Y254Y	0.1
COAD	chr7	99450313	Silent	NA	I115I	0.15
COAD	chr7	99456437	Silent	rs767929343	G249G	0.43
COAD	chr7	99448236	Missense_Mutation	novel	M90I	0.05
COAD	chr7	99453994	Missense_Mutation	rs576966048	S200L	0.27
ESCA	chr7	99456508	3'UTR	novel		0.3
GBM	chr7	99453993	Missense_Mutation	novel	S200A	0.15
HNSC	chr7	99456581	3'UTR	novel		0.16
KIRC	chr7	99448250	Missense_Mutation	NA	E95V	0.16
KIRC	chr7	99450334	Missense_Mutation	NA	K122N	0.15
LAML	chr7	99452373	Missense_Mutation	rs200506342	R168Q	0.07
LAML	chr7	99448148	Missense_Mutation	novel	S61I	0.08
LGG	chr7	99444832	Silent	rs759412959	C49C	0.21
LGG	chr7	99454124	Silent	novel	V243V	0.24
LIHC	chr7	99448179	Missense_Mutation	NA	W71C	0.37
LIHC	chr7	99450293	Frame_Shift_Ins	novel	*C110Mfs19**	0.26
LUAD	chr7	99450310	Silent	NA	H114H	0.31
LUSC	chr7	99448132	Frame_Shift_Del	novel	*P56Qfs26**	0.25
LUSC	chr7	99450770	Missense_Mutation	NA	E158Q	0.15
LUSC	chr7	99439145	Silent	novel	Q21Q	0.55
OV	chr7	99454035	Missense_Mutation	novel	N214H	0.09
OV	chr7	99456524	3'UTR	novel		0.29
OV	chr7	99454092	Missense_Mutation	novel	G233C	0.12
PAAD	chr7	99450320	Missense_Mutation	rs762304791	E118K	0.18
PAAD	chr7	99454052	Silent	rs780938148	P219P	0.22
PCPG	chr7	99456449	Silent	novel	H253H	0.39
SARC	chr7	99457043	3'UTR	novel		0.14
SKCM	chr7	99444814	Silent	rs770988515	F43F	0.16
STAD	chr7	99444793	Silent	rs747343935	S36S	0.46
STAD	chr7	99454062	Missense_Mutation	NA	G223R	0.42
STAD	chr7	99456437	Silent	rs767929343	G249G	0.3
STAD	chr7	99444804	Missense_Mutation	NA	V40A	0.23
STAD	chr7	99456568	3'UTR	novel		0.27
UCEC	chr7	99456492	Missense_Mutation	novel	G268R	0.09
UCEC	chr7	99457212	3'UTR	novel		0.32
UCEC	chr7	99456500	Nonstop_Mutation	novel	270Wext20	0.36
UCEC	chr7	99454087	Missense_Mutation	novel	S231N	0.41
UCEC	chr7	99457335	3'UTR	novel		0.44
UCEC	chr7	99450755	Missense_Mutation	rs371928827	V153M	0.4
UCEC	chr7	99456496	Missense_Mutation	novel	Q269R	0.49
UCEC	chr7	99457366	3'UTR	novel		0.45
UCEC	chr7	99448118	Splice_Region	novel		0.21
UCEC	chr7	99457234	3'UTR	novel		0.21
UCEC	chr7	99457137	3'UTR	rs550946933		0.32
UCEC	chr7	99450313	Silent	NA	I115I	0.55
UCEC	chr7	99448134	Silent	rs147382390	P56P	0.08
UCEC	chr7	99444796	Silent	rs769057045	G37G	0.36
UCEC	chr7	99456659	3'UTR	novel		0.19
UCEC	chr7	99454045	Missense_Mutation	novel	R217I	0.48
UCEC	chr7	99448162	Missense_Mutation	novel	V66I	0.39
UCEC	chr7	99448139	Missense_Mutation	novel	R58H	0.19
UCEC	chr7	99457101	3'UTR	novel		0.36
UCEC	chr7	99454062	Missense_Mutation	NA	G223R	0.47
UCEC	chr7	99456617	3'UTR	novel		0.33
UCEC	chr7	99448255	Missense_Mutation	novel	Y97H	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0556	0.12261
DLBC	AMP	0.2917	0.13215
PAAD	AMP	0.1957	0.0002473
PAAD	DEL	0.0217	0.049388
PRAD	AMP	0.1463	0.012709
TGCT	AMP	0.6333	0.035574
THCA	DEL	0.002	0.27619

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.014	Kaplan-Meier Survival Analysis
PRAD	0.024	Kaplan-Meier Survival Analysis
LUSC	0.015	Kaplan-Meier Survival Analysis
BRCA	0.0016	Kaplan-Meier Survival Analysis
ESCA	0.042	Kaplan-Meier Survival Analysis
PAAD	0.0059	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
UCEC	0.042	Kaplan-Meier Survival Analysis
GBM	0.013	Kaplan-Meier Survival Analysis
LIHC	0.00039	Kaplan-Meier Survival Analysis
DLBC	0.036	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160917 (Gene tree)
Gene ID: 10898
Gene Symbol: CPSF4
Alias: NAR|CPSF30
Full Name: cleavage and polyadenylation specific factor 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 18,452 bases
Position: chr7:99,438,922-99,457,373
Accession: 2327
RBP type: canonical RBP
Summary: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000395311	zf-CCCH	PF00642.24	6.5e-20	1	2
ENSP00000395311	zf-CCCH	PF00642.24	6.5e-20	2	2
ENSP00000402224	zf-CCCH	PF00642.24	9.7e-20	1	2
ENSP00000402224	zf-CCCH	PF00642.24	9.7e-20	2	2
ENSP00000292476	zf-CCCH	PF00642.24	1.2e-19	1	2
ENSP00000292476	zf-CCCH	PF00642.24	1.2e-19	2	2
ENSP00000401150	zf-CCCH	PF00642.24	1.4e-16	1	2
ENSP00000401150	zf-CCCH	PF00642.24	1.4e-16	2	2
ENSP00000396060	zf-CCCH	PF00642.24	5e-15	1	2
ENSP00000396060	zf-CCCH	PF00642.24	5e-15	2	2
ENSP00000392584	zf-CCCH	PF00642.24	4.2e-11	1	1
ENSP00000415188	zf-CCCH	PF00642.24	7.9e-07	1	1
ENSP00000402224	zf-CCHC	PF00098.23	1e-05	1	1
ENSP00000396060	zf-CCHC	PF00098.23	1.2e-05	1	1
ENSP00000395311	zf-CCHC	PF00098.23	1.4e-05	1	1
ENSP00000292476	zf-CCHC	PF00098.23	1.6e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18331819	Redox and heavy metal effects on the biochemical activities of an Arabidopsis polyadenylation factor subunit.	Arch Biochem Biophys	2008 May 1	Addepalli B	doi: 10.1016/j.abb.2008.02.027
23255794	Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells.	J Virol	2013 Mar	Ramos I	doi: 10.1128/JVI.02247-12
25174360	Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation.	Virol J	2014 Aug 31	Sanchez A	doi: 10.1186/1743-422X-11-155.
27071088	Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe-2S cluster.	Proc Natl Acad Sci U S A	2016 Apr 26	Shimberg GD	doi: 10.1073/pnas.1517620113
29274231	Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.	Elife	2017 Dec 23	Clerici M	doi: 10.7554/eLife.33111.
30258002	Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.	J Virol	2018 Nov 27	Zhang L	doi: 10.1128/JVI.01634-18
25301781	Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.	Genes Dev	2014 Nov 1	Schonemann L	doi: 10.1101/gad.250985.114

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430038	CPSF4-203	735	-	ENSP00000401496	44 (aa)	-	F8WEL7
ENST00000436336	CPSF4-204	1738	XM_011515756	ENSP00000395311	244 (aa)	XP_011514058	O95639
ENST00000482251	CPSF4-212	574	-	-	- (aa)	-	-
ENST00000484112	CPSF4-213	825	-	-	- (aa)	-	-
ENST00000292476	CPSF4-201	1691	XM_011515755	ENSP00000292476	269 (aa)	XP_011514057	O95639
ENST00000452047	CPSF4-208	687	-	ENSP00000392584	229 (aa)	-	H7C016
ENST00000412686	CPSF4-202	745	-	ENSP00000401150	112 (aa)	-	C9K0K2
ENST00000440514	CPSF4-205	578	-	ENSP00000415188	193 (aa)	-	H7C419
ENST00000465132	CPSF4-209	927	-	-	- (aa)	-	-
ENST00000441580	CPSF4-206	942	XM_017011702	ENSP00000402224	191 (aa)	XP_016867191	B7Z7B0
ENST00000451876	CPSF4-207	1644	-	ENSP00000396060	211 (aa)	-	C9JEV9
ENST00000471455	CPSF4-211	569	-	-	- (aa)	-	-
ENST00000469897	CPSF4-210	689	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000160917's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG
hsa05164	Influenza A	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000160917	rs13243267	7	99455691	?	Serum metabolite levels	23093944	[NR] unit decrease	0.1191	EFO_0005653
ENSG00000160917	rs883403	7	99450355	T	Smoking status (ever vs never smokers)	30643258	[0.012-0.023] unit increase	0.017332198	EFO_0004318
ENSG00000160917	rs10215854	7	99439297	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160917's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000160917	CPSF4	99	74.775	ENSG00000187959	CPSF4L	92	67.683

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160917	CPSF4	69	81.818	ENSAPOG00000004921	cpsf4	100	74.176	Acanthochromis_polyacanthus
ENSG00000160917	CPSF4	100	100.000	ENSAMEG00000006252	CPSF4	100	99.257	Ailuropoda_melanoleuca
ENSG00000160917	CPSF4	100	98.214	ENSACIG00000009248	cpsf4	100	87.705	Amphilophus_citrinellus
ENSG00000160917	CPSF4	100	98.214	ENSAOCG00000019616	cpsf4	100	84.815	Amphiprion_ocellaris
ENSG00000160917	CPSF4	100	98.214	ENSAPEG00000011679	cpsf4	100	84.815	Amphiprion_percula
ENSG00000160917	CPSF4	100	98.214	ENSATEG00000007010	cpsf4	100	85.425	Anabas_testudineus
ENSG00000160917	CPSF4	100	98.214	ENSACAG00000012941	CPSF4	89	93.680	Anolis_carolinensis
ENSG00000160917	CPSF4	100	100.000	ENSANAG00000021360	CPSF4	100	100.000	Aotus_nancymaae
ENSG00000160917	CPSF4	100	98.214	ENSACLG00000010374	cpsf4	100	84.074	Astatotilapia_calliptera
ENSG00000160917	CPSF4	100	97.321	ENSAMXG00000031647	cpsf4	100	85.978	Astyanax_mexicanus
ENSG00000160917	CPSF4	100	100.000	ENSBTAG00000002090	CPSF4	100	98.770	Bos_taurus
ENSG00000160917	CPSF4	100	100.000	ENSCJAG00000015826	CPSF4	100	100.000	Callithrix_jacchus
ENSG00000160917	CPSF4	100	100.000	ENSCAFG00000015036	CPSF4	100	98.885	Canis_familiaris
ENSG00000160917	CPSF4	100	100.000	ENSCAFG00020014462	CPSF4	100	92.565	Canis_lupus_dingo
ENSG00000160917	CPSF4	100	100.000	ENSCHIG00000014313	CPSF4	100	99.257	Capra_hircus
ENSG00000160917	CPSF4	100	100.000	ENSTSYG00000005712	-	100	99.180	Carlito_syrichta
ENSG00000160917	CPSF4	100	92.857	ENSTSYG00000008195	-	99	91.556	Carlito_syrichta
ENSG00000160917	CPSF4	100	90.625	ENSTSYG00000014604	-	100	90.204	Carlito_syrichta
ENSG00000160917	CPSF4	100	100.000	ENSCAPG00000013881	CPSF4	87	99.083	Cavia_aperea
ENSG00000160917	CPSF4	100	100.000	ENSCPOG00000001783	CPSF4	100	99.180	Cavia_porcellus
ENSG00000160917	CPSF4	100	100.000	ENSCCAG00000028291	CPSF4	100	100.000	Cebus_capucinus
ENSG00000160917	CPSF4	100	100.000	ENSCATG00000038440	CPSF4	100	100.000	Cercocebus_atys
ENSG00000160917	CPSF4	100	100.000	ENSCLAG00000007050	CPSF4	100	99.257	Chinchilla_lanigera
ENSG00000160917	CPSF4	100	100.000	ENSCSAG00000017795	CPSF4	100	100.000	Chlorocebus_sabaeus
ENSG00000160917	CPSF4	100	99.107	ENSCPBG00000020869	CPSF4	100	95.833	Chrysemys_picta_bellii
ENSG00000160917	CPSF4	100	88.393	ENSCPBG00000010269	-	100	80.723	Chrysemys_picta_bellii
ENSG00000160917	CPSF4	99	76.577	ENSCING00000021080	-	97	55.939	Ciona_intestinalis
ENSG00000160917	CPSF4	99	76.577	ENSCSAVG00000011469	-	97	53.546	Ciona_savignyi
ENSG00000160917	CPSF4	100	100.000	ENSCANG00000019384	CPSF4	100	100.000	Colobus_angolensis_palliatus
ENSG00000160917	CPSF4	100	100.000	ENSCGRG00001024184	Cpsf4	100	99.180	Cricetulus_griseus_chok1gshd
ENSG00000160917	CPSF4	100	100.000	ENSCGRG00000013892	Cpsf4	100	99.257	Cricetulus_griseus_crigri
ENSG00000160917	CPSF4	100	98.214	ENSCSEG00000019055	cpsf4	100	84.360	Cynoglossus_semilaevis
ENSG00000160917	CPSF4	100	98.214	ENSCVAG00000016528	cpsf4	100	83.333	Cyprinodon_variegatus
ENSG00000160917	CPSF4	100	98.214	ENSDARG00000020217	cpsf4	100	85.240	Danio_rerio
ENSG00000160917	CPSF4	100	100.000	ENSDNOG00000006344	CPSF4	100	99.628	Dasypus_novemcinctus
ENSG00000160917	CPSF4	100	99.107	ENSDORG00000000742	Cpsf4	100	98.618	Dipodomys_ordii
ENSG00000160917	CPSF4	99	81.982	FBgn0015621	Clp	99	54.110	Drosophila_melanogaster
ENSG00000160917	CPSF4	100	99.107	ENSETEG00000002608	CPSF4	70	100.000	Echinops_telfairi
ENSG00000160917	CPSF4	100	91.964	ENSEBUG00000012552	cpsf4	98	70.370	Eptatretus_burgeri
ENSG00000160917	CPSF4	100	100.000	ENSEASG00005002487	CPSF4	100	99.180	Equus_asinus_asinus
ENSG00000160917	CPSF4	100	100.000	ENSECAG00000007525	CPSF4	100	99.257	Equus_caballus
ENSG00000160917	CPSF4	68	100.000	ENSEEUG00000002158	CPSF4	73	100.000	Erinaceus_europaeus
ENSG00000160917	CPSF4	100	97.321	ENSELUG00000011481	cpsf4	100	82.847	Esox_lucius
ENSG00000160917	CPSF4	100	100.000	ENSFCAG00000015070	CPSF4	100	99.257	Felis_catus
ENSG00000160917	CPSF4	94	67.857	ENSFALG00000012906	-	100	56.977	Ficedula_albicollis
ENSG00000160917	CPSF4	100	99.107	ENSFALG00000013799	CPSF4	100	95.082	Ficedula_albicollis
ENSG00000160917	CPSF4	100	100.000	ENSFDAG00000014092	CPSF4	100	98.354	Fukomys_damarensis
ENSG00000160917	CPSF4	100	98.214	ENSFHEG00000010880	cpsf4	100	82.963	Fundulus_heteroclitus
ENSG00000160917	CPSF4	100	97.321	ENSGMOG00000002330	cpsf4	100	80.233	Gadus_morhua
ENSG00000160917	CPSF4	99	39.888	ENSGALG00000004441	-	98	38.764	Gallus_gallus
ENSG00000160917	CPSF4	100	99.107	ENSGALG00000004714	CPSF4	100	95.082	Gallus_gallus
ENSG00000160917	CPSF4	100	97.321	ENSGAFG00000010580	cpsf4	100	82.222	Gambusia_affinis
ENSG00000160917	CPSF4	100	97.321	ENSGACG00000007792	cpsf4	100	82.283	Gasterosteus_aculeatus
ENSG00000160917	CPSF4	100	88.393	ENSGAGG00000020579	-	92	81.212	Gopherus_agassizii
ENSG00000160917	CPSF4	100	99.107	ENSGAGG00000021835	CPSF4	100	95.911	Gopherus_agassizii
ENSG00000160917	CPSF4	100	100.000	ENSGGOG00000015131	CPSF4	100	100.000	Gorilla_gorilla
ENSG00000160917	CPSF4	100	98.214	ENSHBUG00000013699	cpsf4	100	84.074	Haplochromis_burtoni
ENSG00000160917	CPSF4	100	100.000	ENSHGLG00000017150	CPSF4	100	98.578	Heterocephalus_glaber_female
ENSG00000160917	CPSF4	98	100.000	ENSHGLG00100009215	-	100	96.023	Heterocephalus_glaber_male
ENSG00000160917	CPSF4	100	70.616	ENSHGLG00100017302	-	100	68.720	Heterocephalus_glaber_male
ENSG00000160917	CPSF4	100	98.214	ENSHCOG00000004397	cpsf4	100	80.741	Hippocampus_comes
ENSG00000160917	CPSF4	100	98.214	ENSIPUG00000017147	cpsf4	100	85.294	Ictalurus_punctatus
ENSG00000160917	CPSF4	100	100.000	ENSSTOG00000001688	CPSF4	100	99.257	Ictidomys_tridecemlineatus
ENSG00000160917	CPSF4	100	100.000	ENSJJAG00000019426	Cpsf4	100	99.257	Jaculus_jaculus
ENSG00000160917	CPSF4	100	96.429	ENSKMAG00000015642	cpsf4	100	81.852	Kryptolebias_marmoratus
ENSG00000160917	CPSF4	100	98.214	ENSLACG00000010938	CPSF4	100	89.259	Latimeria_chalumnae
ENSG00000160917	CPSF4	100	84.956	ENSLACG00000018470	-	100	64.490	Latimeria_chalumnae
ENSG00000160917	CPSF4	100	97.321	ENSLOCG00000004814	cpsf4	100	89.219	Lepisosteus_oculatus
ENSG00000160917	CPSF4	100	100.000	ENSLAFG00000000159	CPSF4	100	98.885	Loxodonta_africana
ENSG00000160917	CPSF4	100	100.000	ENSMFAG00000001462	CPSF4	100	100.000	Macaca_fascicularis
ENSG00000160917	CPSF4	100	100.000	ENSMMUG00000019191	CPSF4	100	100.000	Macaca_mulatta
ENSG00000160917	CPSF4	100	100.000	ENSMNEG00000032306	CPSF4	100	100.000	Macaca_nemestrina
ENSG00000160917	CPSF4	100	100.000	ENSMLEG00000034721	CPSF4	100	100.000	Mandrillus_leucophaeus
ENSG00000160917	CPSF4	100	98.214	ENSMAMG00000006244	cpsf4	100	84.074	Mastacembelus_armatus
ENSG00000160917	CPSF4	100	98.214	ENSMZEG00005007515	cpsf4	100	84.074	Maylandia_zebra
ENSG00000160917	CPSF4	100	99.107	ENSMGAG00000004235	CPSF4	100	94.762	Meleagris_gallopavo
ENSG00000160917	CPSF4	100	100.000	ENSMAUG00000021253	Cpsf4	100	99.257	Mesocricetus_auratus
ENSG00000160917	CPSF4	100	100.000	ENSMICG00000017429	CPSF4	100	99.628	Microcebus_murinus
ENSG00000160917	CPSF4	100	100.000	ENSMOCG00000014901	Cpsf4	100	99.257	Microtus_ochrogaster
ENSG00000160917	CPSF4	100	98.214	ENSMMOG00000001813	cpsf4	100	85.308	Mola_mola
ENSG00000160917	CPSF4	100	100.000	ENSMODG00000001367	CPSF4	100	97.770	Monodelphis_domestica
ENSG00000160917	CPSF4	100	96.429	ENSMALG00000012611	cpsf4	100	82.963	Monopterus_albus
ENSG00000160917	CPSF4	100	100.000	MGP_CAROLIEiJ_G0028012	Cpsf4	100	99.257	Mus_caroli
ENSG00000160917	CPSF4	100	100.000	ENSMUSG00000029625	Cpsf4	100	99.257	Mus_musculus
ENSG00000160917	CPSF4	100	100.000	MGP_PahariEiJ_G0024581	Cpsf4	100	99.257	Mus_pahari
ENSG00000160917	CPSF4	100	100.000	MGP_SPRETEiJ_G0029013	Cpsf4	100	99.628	Mus_spretus
ENSG00000160917	CPSF4	100	100.000	ENSMPUG00000016508	CPSF4	100	99.257	Mustela_putorius_furo
ENSG00000160917	CPSF4	100	100.000	ENSMLUG00000010980	CPSF4	100	98.095	Myotis_lucifugus
ENSG00000160917	CPSF4	100	100.000	ENSNGAG00000001567	Cpsf4	100	98.885	Nannospalax_galili
ENSG00000160917	CPSF4	100	98.214	ENSNBRG00000003943	cpsf4	98	83.740	Neolamprologus_brichardi
ENSG00000160917	CPSF4	100	100.000	ENSNLEG00000011074	CPSF4	100	100.000	Nomascus_leucogenys
ENSG00000160917	CPSF4	100	100.000	ENSMEUG00000006955	CPSF4	100	97.770	Notamacropus_eugenii
ENSG00000160917	CPSF4	100	100.000	ENSOPRG00000013663	CPSF4	100	98.885	Ochotona_princeps
ENSG00000160917	CPSF4	100	100.000	ENSODEG00000011181	-	100	99.257	Octodon_degus
ENSG00000160917	CPSF4	100	75.000	ENSODEG00000009779	-	100	74.359	Octodon_degus
ENSG00000160917	CPSF4	100	92.857	ENSODEG00000018283	-	91	84.583	Octodon_degus
ENSG00000160917	CPSF4	100	98.214	ENSONIG00000008495	cpsf4	100	84.074	Oreochromis_niloticus
ENSG00000160917	CPSF4	100	80.357	ENSOANG00000009568	-	100	52.518	Ornithorhynchus_anatinus
ENSG00000160917	CPSF4	100	100.000	ENSOANG00000007729	CPSF4	100	96.170	Ornithorhynchus_anatinus
ENSG00000160917	CPSF4	100	100.000	ENSOCUG00000002437	CPSF4	70	98.885	Oryctolagus_cuniculus
ENSG00000160917	CPSF4	100	98.214	ENSORLG00000022798	cpsf4	100	83.271	Oryzias_latipes
ENSG00000160917	CPSF4	100	98.214	ENSORLG00020008548	cpsf4	100	83.271	Oryzias_latipes_hni
ENSG00000160917	CPSF4	100	98.214	ENSORLG00015019575	cpsf4	100	82.900	Oryzias_latipes_hsok
ENSG00000160917	CPSF4	100	97.321	ENSOMEG00000005176	cpsf4	100	83.886	Oryzias_melastigma
ENSG00000160917	CPSF4	100	100.000	ENSOGAG00000010884	CPSF4	100	99.628	Otolemur_garnettii
ENSG00000160917	CPSF4	96	93.519	ENSOARG00000018668	CPSF4	100	87.912	Ovis_aries
ENSG00000160917	CPSF4	100	100.000	ENSPPAG00000043355	CPSF4	100	99.628	Pan_paniscus
ENSG00000160917	CPSF4	100	100.000	ENSPPRG00000003134	CPSF4	100	99.257	Panthera_pardus
ENSG00000160917	CPSF4	100	100.000	ENSPTIG00000005604	CPSF4	90	99.174	Panthera_tigris_altaica
ENSG00000160917	CPSF4	100	100.000	ENSPTRG00000019453	CPSF4	100	99.628	Pan_troglodytes
ENSG00000160917	CPSF4	100	100.000	ENSPANG00000023123	CPSF4	100	100.000	Papio_anubis
ENSG00000160917	CPSF4	100	98.214	ENSPKIG00000014278	cpsf4	100	84.307	Paramormyrops_kingsleyae
ENSG00000160917	CPSF4	100	84.821	ENSPSIG00000018198	-	100	64.767	Pelodiscus_sinensis
ENSG00000160917	CPSF4	100	99.107	ENSPSIG00000011229	CPSF4	100	95.370	Pelodiscus_sinensis
ENSG00000160917	CPSF4	100	98.214	ENSPMGG00000017735	cpsf4	100	78.862	Periophthalmus_magnuspinnatus
ENSG00000160917	CPSF4	100	100.000	ENSPEMG00000004508	Cpsf4	100	99.257	Peromyscus_maniculatus_bairdii
ENSG00000160917	CPSF4	100	100.000	ENSPCIG00000024776	CPSF4	100	97.770	Phascolarctos_cinereus
ENSG00000160917	CPSF4	100	97.321	ENSPFOG00000014912	cpsf4	100	82.222	Poecilia_formosa
ENSG00000160917	CPSF4	100	97.321	ENSPLAG00000009599	cpsf4	100	78.862	Poecilia_latipinna
ENSG00000160917	CPSF4	100	97.321	ENSPMEG00000009790	cpsf4	100	82.222	Poecilia_mexicana
ENSG00000160917	CPSF4	100	97.321	ENSPREG00000018166	cpsf4	100	79.182	Poecilia_reticulata
ENSG00000160917	CPSF4	100	99.107	ENSPPYG00000017378	CPSF4	100	99.145	Pongo_abelii
ENSG00000160917	CPSF4	100	100.000	ENSPCAG00000001892	CPSF4	100	98.141	Procavia_capensis
ENSG00000160917	CPSF4	100	100.000	ENSPCOG00000012771	CPSF4	100	99.257	Propithecus_coquereli
ENSG00000160917	CPSF4	100	100.000	ENSPVAG00000007531	CPSF4	100	92.565	Pteropus_vampyrus
ENSG00000160917	CPSF4	100	98.214	ENSPNYG00000018559	cpsf4	100	84.074	Pundamilia_nyererei
ENSG00000160917	CPSF4	100	98.214	ENSPNAG00000003736	cpsf4	100	87.085	Pygocentrus_nattereri
ENSG00000160917	CPSF4	100	100.000	ENSRNOG00000000985	Cpsf4	100	99.052	Rattus_norvegicus
ENSG00000160917	CPSF4	100	100.000	ENSRBIG00000033886	CPSF4	100	100.000	Rhinopithecus_bieti
ENSG00000160917	CPSF4	100	100.000	ENSRROG00000040431	CPSF4	100	100.000	Rhinopithecus_roxellana
ENSG00000160917	CPSF4	100	100.000	ENSSBOG00000020493	CPSF4	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000160917	CPSF4	100	100.000	ENSSHAG00000011533	CPSF4	100	97.770	Sarcophilus_harrisii
ENSG00000160917	CPSF4	100	97.321	ENSSFOG00015007883	cpsf4	100	86.232	Scleropages_formosus
ENSG00000160917	CPSF4	100	97.321	ENSSMAG00000006374	cpsf4	100	86.235	Scophthalmus_maximus
ENSG00000160917	CPSF4	100	98.214	ENSSDUG00000018887	cpsf4	100	83.333	Seriola_dumerili
ENSG00000160917	CPSF4	100	98.214	ENSSLDG00000019078	cpsf4	100	84.074	Seriola_lalandi_dorsalis
ENSG00000160917	CPSF4	100	100.000	ENSSARG00000012416	CPSF4	100	99.573	Sorex_araneus
ENSG00000160917	CPSF4	100	86.607	ENSSPUG00000014803	-	97	64.135	Sphenodon_punctatus
ENSG00000160917	CPSF4	100	98.214	ENSSPUG00000003549	CPSF4	100	94.424	Sphenodon_punctatus
ENSG00000160917	CPSF4	100	98.214	ENSSPAG00000006174	cpsf4	100	87.295	Stegastes_partitus
ENSG00000160917	CPSF4	100	100.000	ENSSSCG00000026896	CPSF4	100	99.590	Sus_scrofa
ENSG00000160917	CPSF4	100	99.107	ENSTGUG00000007552	CPSF4	100	93.902	Taeniopygia_guttata
ENSG00000160917	CPSF4	100	98.214	ENSTRUG00000024220	cpsf4	100	81.111	Takifugu_rubripes
ENSG00000160917	CPSF4	100	98.214	ENSTNIG00000006265	cpsf4	100	81.481	Tetraodon_nigroviridis
ENSG00000160917	CPSF4	100	92.857	ENSTBEG00000011406	CPSF4	100	90.171	Tupaia_belangeri
ENSG00000160917	CPSF4	100	100.000	ENSTTRG00000003007	CPSF4	100	78.810	Tursiops_truncatus
ENSG00000160917	CPSF4	100	100.000	ENSUAMG00000008051	CPSF4	85	98.649	Ursus_americanus
ENSG00000160917	CPSF4	100	100.000	ENSUMAG00000009474	CPSF4	100	98.770	Ursus_maritimus
ENSG00000160917	CPSF4	100	100.000	ENSVVUG00000008824	CPSF4	100	98.770	Vulpes_vulpes
ENSG00000160917	CPSF4	99	87.387	ENSXETG00000004641	cpsf4l	99	60.821	Xenopus_tropicalis
ENSG00000160917	CPSF4	100	90.164	ENSXETG00000009892	cpsf4	100	88.172	Xenopus_tropicalis
ENSG00000160917	CPSF4	100	97.321	ENSXCOG00000016040	cpsf4	100	83.886	Xiphophorus_couchianus
ENSG00000160917	CPSF4	100	97.321	ENSXMAG00000024670	cpsf4	100	82.222	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	19136632.25416956.28169297.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	21873635.	IBA	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	21102410.	IDA	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0046778	modification by virus of host mRNA processing	-	TAS	Process
GO:0098789	pre-mRNA cleavage required for polyadenylation	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.