EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
15713990Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis.Oncology2004Notarnicola M-
22407328Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?World J Urol2013 AprTodenhfer Tdoi: 10.1007/s00345-012-0844-y
29337059FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway.Biochem Biophys Res Commun2018 Feb 5Lin Ldoi: 10.1016/j.bbrc.2018.01.066

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1155318905Missense_MutationNAP275A0.46
BLCAchr1155318312Intronrs7592691920.36
BLCAchr1155318304Intronnovel0.24
BLCAchr1155319864Missense_MutationnovelK332T0.07
BLCAchr1155309901Missense_MutationnovelG38W0.32
BLCAchr1155318674Missense_MutationnovelQ232E0.15
BLCAchr1155310121Missense_MutationnovelQ85H0.09
BRCAchr1155312373Missense_MutationNAT153N0.15
BRCAchr1155320486SilentNAV379V0.54
BRCAchr1155320489SilentNAF380F0.21
BRCAchr1155318278Missense_MutationnovelE224V0.13
BRCAchr1155318279In_Frame_InsnovelE224_L225insSTLTLL0.13
BRCAchr1155320499Missense_MutationnovelE384K0.36
BRCAchr1155319905Missense_MutationNAP346A0.2
BRCAchr1155320531SilentNAL394L0.15
BRCAchr11553206163'UTRnovel0.38
BRCAchr1155319820Frame_Shift_DelNAS319Vfs*20.29
BRCAchr1155319905Missense_MutationNAP346A0.13
CESCchr1155312363Missense_MutationnovelR150W0.21
CESCchr1155310160Missense_MutationNAE98D0.25
CESCchr1155318282SilentNAL225L0.32
CESCchr1155318016Missense_MutationNAQ186E0.31
CESCchr1155318898Missense_MutationNAF272L0.14
CESCchr1155318736SilentNAV252V0.36
CESCchr1155320529Missense_MutationNAL394V0.14
COADchr1155320581Missense_MutationNAA411V0.28
COADchr1155317840IntronNA0.64
COADchr1155317840IntronNA0.34
COADchr1155309853Frame_Shift_DelNAR23Gfs*450.31
COADchr1155310155Missense_MutationnovelD97H0.13
COADchr1155309955Missense_MutationNAE56K0.4
COADchr1155317840IntronNA0.08
COADchr1155317840IntronNA0.1
COADchr1155318678Missense_MutationNAT233S0.12
COADchr1155320515Missense_MutationNAS389N0.4
COADchr1155317947Missense_MutationnovelA163T0.08
COADchr1155317840IntronNA0.29
COADchr1155312310Missense_MutationnovelV132E0.32
COADchr1155317840IntronNA0.32
DLBCchr1155318240SilentnovelL211L0.28
ESCAchr1155318676SilentnovelQ232Q0.13
ESCAchr1155319642Missense_MutationnovelN293S0.1
ESCAchr1155317840IntronNA0.3
ESCAchr1155320556Missense_MutationnovelP403T0.18
GBMchr1155317992Missense_Mutationrs749581999R178C0.34
GBMchr1155318242Missense_MutationNAY212C0.39
GBMchr1155312277Missense_MutationnovelG121E0.16
HNSCchr1155318358Intronnovel0.13
HNSCchr1155319680Nonsense_MutationnovelQ306*0.17
HNSCchr1155310152Missense_MutationnovelE96K0.22
KIRCchr1155309945SilentNAQ52Q0.31
KIRPchr1155309918SilentnovelA43A0.42
LAMLchr1155319949Intronnovel0.11
LIHCchr1155312367Missense_MutationnovelA151V0.09
LIHCchr1155317840IntronNA0.11
LIHCchr1155319895SilentNAQ342Q0.6
LUADchr1155318914Missense_MutationnovelA278P0.14
LUADchr1155319833Missense_MutationnovelG322S0.1
LUADchr1155318240SilentNAL211L0.05
LUADchr1155319833Missense_MutationNAG322R0.04
LUADchr1155320581Missense_MutationNAA411V0.14
LUADchr1155317848Intronnovel0.3
LUADchr1155317961SilentNAV167V0.13
LUSCchr11553206353'UTRnovel0.18
LUSCchr1155310152Missense_MutationnovelE96Q0.19
LUSCchr1155318749Missense_MutationnovelK257Q0.37
LUSCchr1155319953Intronnovel0.52
LUSCchr1155318876Missense_MutationNAY265F0.26
OVchr1155319659Missense_MutationnovelL299M0.04
OVchr1155319625Silentrs775781022G287G0.48
PAADchr1155318351Intronnovel0.21
PAADchr1155319682SilentnovelQ306Q0.19
READchr11553206593'UTRnovel0.15
READchr1155317840IntronNA0.1
SARCchr1155320543In_Frame_DelnovelA399_P401del0.43
SARCchr1155318232Missense_MutationnovelL209V0.4
SARCchr1155317857Intronnovel0.35
SKCMchr1155318360Intronnovel0.14
SKCMchr1155310133SilentnovelQ89Q0.47
SKCMchr1155309913SilentnovelL42L0.6
SKCMchr1155320583Missense_MutationNAR412C0.56
SKCMchr1155318270SilentnovelN221N0.24
SKCMchr1155310115Silentrs765803031F83F0.15
SKCMchr1155319932Splice_Regionnovel0.33
SKCMchr1155319933Splice_Regionnovel0.33
SKCMchr1155309861Missense_MutationNAE24D0.28
SKCMchr1155310129Missense_MutationNAS88F0.27
STADchr1155317978Missense_MutationNAD173A0.22
STADchr1155318710Frame_Shift_InsnovelQ246Pfs*320.11
STADchr1155320592Missense_MutationNAY415H0.34
STADchr1155312364Missense_Mutationrs373639609R150Q0.44
STADchr1155319950Intronnovel0.39
STADchr1155318277Missense_Mutationrs139546057E224K0.18
STADchr1155320582Silentrs779964878A411A0.36
STADchr1155318711Frame_Shift_DelnovelQ246Rfs*310.21
STADchr1155320541Missense_MutationNAY398H0.07
STADchr1155319821Missense_MutationnovelP318S0.19
STADchr1155318175Missense_Mutationrs757544890V190M0.07
UCECchr1155317840IntronNA0.28
UCECchr1155318277Missense_Mutationrs139546057E224K0.37
UCECchr1155317848Intronnovel0.18
UCECchr1155318170Missense_MutationnovelP188L0.36
UCECchr1155318373Intronnovel0.18
UCECchr1155320422In_Frame_Delrs771519284K359del0.12
UCECchr1155318895In_Frame_DelNAF272del0.03
UCECchr1155318898Missense_MutationNAF272L0.13
UCECchr1155317840IntronNA0.24
UCECchr1155310071Missense_Mutationrs775764683G69R0.28
UCECchr1155320565Missense_MutationNAV406I0.3
UCECchr1155320547Missense_MutationNAA400T0.14
UCECchr1155318312Intronrs7592691920.32
UCECchr1155317993Missense_Mutationrs771194005R178H0.5
UCECchr1155318272Missense_MutationnovelL222P0.34
UCECchr1155318267SilentnovelL220L0.33
UCECchr1155317840IntronNA0.34
UCECchr1155320515Missense_MutationnovelS389I0.49
UCECchr1155309789Splice_Regionnovel0.59
UCECchr1155318197Missense_MutationNAD197G0.33
UCECchr1155318698Missense_MutationNAD240Y0.44
UCECchr1155310047Missense_MutationNAL61I0.21
UCECchr1155317863Intronnovel0.36
UCECchr1155320423SilentnovelQ358Q0.43
UCECchr1155317840IntronNA0.31
UCECchr1155312281SilentnovelG122G0.42
UCECchr1155309910Missense_MutationnovelV41F0.5
UCECchr1155319932Splice_Regionrs7670895690.43
UCECchr1155318349Intronnovel0.29
UCECchr1155310081Missense_MutationnovelN72I0.52
UCECchr1155310079Missense_MutationNAQ71H0.37
UCECchr1155319838Missense_MutationNAK323N0.06
UCECchr1155320456Silentrs186015551A369A0.24
UCECchr1155317840IntronNA0.27
UCECchr1155318322Intronnovel0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.14440.11282
CESCAMP0.48143.2002e-05
DLBCDEL0.02080.0017831
ESCAAMP0.38590.0022446
KIRCAMP0.09280.059566
PAADAMP0.22280.085665
PRADAMP0.07320.00077815
READAMP0.26670.025154
SKCMAMP0.49059.6912e-06
TGCTAMP0.340.088103

Survival Analysis
CancerP-value Q-value
KIRC0.00012

Kaplan-Meier Survival Analysis

MESO0.00046

Kaplan-Meier Survival Analysis

ACC0.011

Kaplan-Meier Survival Analysis

SKCM0.00026

Kaplan-Meier Survival Analysis

PRAD0.037

Kaplan-Meier Survival Analysis

ESCA0.037

Kaplan-Meier Survival Analysis

KIRP0.007

Kaplan-Meier Survival Analysis

PCPG0.038

Kaplan-Meier Survival Analysis

CESC0.00037

Kaplan-Meier Survival Analysis

LAML0.0063

Kaplan-Meier Survival Analysis

KICH0.026

Kaplan-Meier Survival Analysis

UCEC0.044

Kaplan-Meier Survival Analysis

GBM0.02

Kaplan-Meier Survival Analysis

LIHC0.0012

Kaplan-Meier Survival Analysis

DLBC0.016

Kaplan-Meier Survival Analysis

LGG0.00012

Kaplan-Meier Survival Analysis

LUAD0.00078

Kaplan-Meier Survival Analysis

UVM0.00014

Kaplan-Meier Survival Analysis

OV0.002

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000160752 (Gene tree)
Gene ID
2224
Gene Symbol
FDPS
Alias
N
Full Name
farnesyl diphosphate synthase
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
11,919 bases
Position
chr1:155,308,748-155,320,666
Accession
3631
RBP type
non-canonical RBP
Summary
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000611010FDPS-2201196XM_024454076ENSP00000483188248 (aa)XP_024309844A0A087X090
ENST00000356657FDPS-2011478XM_024454070ENSP00000349078419 (aa)XP_024309838P14324
ENST00000461507FDPS-2041022--- (aa)--
ENST00000368356FDPS-2021431XM_024454066ENSP00000357340419 (aa)XP_024309834P14324
ENST00000474345FDPS-210713-ENSP0000047803280 (aa)-A0A087WTP2
ENST00000470171FDPS-208746--- (aa)--
ENST00000489003FDPS-213976--- (aa)--
ENST00000477057FDPS-211741--- (aa)--
ENST00000447866FDPS-2031256XM_024454071ENSP00000391755353 (aa)XP_024309839P14324
ENST00000491013FDPS-216912-ENSP00000479557274 (aa)-A0A087WVN4
ENST00000490140FDPS-215680--- (aa)--
ENST00000492244FDPS-217673--- (aa)--
ENST00000495308FDPS-219808--- (aa)--
ENST00000467076FDPS-2061178XM_024454072ENSP00000480142353 (aa)XP_024309840P14324
ENST00000487002FDPS-2122017--- (aa)--
ENST00000465559FDPS-205677-ENSP00000484099174 (aa)-A0A087X1D8
ENST00000471117FDPS-209630--- (aa)--
ENST00000492887FDPS-218554--- (aa)--
ENST00000489324FDPS-214475--- (aa)--
ENST00000468479FDPS-207938--- (aa)--
ENST00000612683FDPS-2211198XM_005244962ENSP00000478235353 (aa)XP_005245019P14324
Gene Model
Click here to download ENSG00000160752's gene model file
Pathways
Pathway IDPathway NameSource
hsa00900Terpenoid backbone biosynthesisKEGG
hsa01100Metabolic pathwaysKEGG
hsa05164Influenza AKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160752's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000160752FDPS10049.200YJL167WERG209845.376Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0004161dimethylallyltranstransferase activity21873635.IBAFunction
GO:0004337geranyltranstransferase activity21873635.IBAFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006695cholesterol biosynthetic process-TASProcess
GO:0016032viral process-IEAProcess
GO:0033384geranyl diphosphate biosynthetic process-IEAProcess
GO:0045337farnesyl diphosphate biosynthetic process21873635.IBAProcess
GO:0045337farnesyl diphosphate biosynthetic process-IEAProcess
GO:0045540regulation of cholesterol biosynthetic process-TASProcess
GO:0046872metal ion binding-IEAFunction
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us