EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30798327ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.Med Sci Monit2019 Feb 24Yu Jdoi: 10.12659/MSM.911944.
24928581ADAR1: a promising new biomarker for esophageal squamous cell carcinoma?Expert Rev Anticancer Ther2014 AugQiao JJdoi: 10.1586/14737140.2014.928595
30290838ADAR1-mediated RNA-editing of 3'UTRs in breast cancer.Biol Res2018 Oct 5Sagredo EAdoi: 10.1186/s40659-018-0185-4.
23728176MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.J Clin Invest2013 JunNemlich Y-
28109322ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.Diagn Pathol2017 Jan 21Chen Ydoi: 10.1186/s13000-017-0600-0.
26640150Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.Oncogene2016 Aug 18Anad??n Cdoi: 10.1038/onc.2015.469
29022489ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.Tumour Biol2017 OctSong IHdoi: 10.1177/1010428317734816.
27863387Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.Oncotarget2016 Dec 27Dou Ndoi: 10.18632/oncotarget.13354.
29691780Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.Dig Dis Sci2018 JulCho CJdoi: 10.1007/s10620-018-5081-9
29996118CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients.Cell Physiol Biochem2018Dong Xdoi: 10.1159/000491656
29855470ADAR1-mediated regulation of melanoma invasion.Nat Commun2018 May 31Nemlich Ydoi: 10.1038/s41467-018-04600-2.
30575730Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.Nat Commun2018 Dec 21Gannon HSdoi: 10.1038/s41467-018-07824-4.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1154601208SilentnovelE478E0.42
BLCAchr1154597923Missense_MutationnovelK613N0.18
BLCAchr1154602501SilentnovelL47L0.44
BLCAchr1154602355Missense_MutationnovelG96D0.77
BLCAchr1154601253SilentNAL463L0.09
BLCAchr1154590230Missense_MutationNAR817T0.37
BLCAchr1154601360Missense_MutationnovelE428Q0.3
BLCAchr11545846163'UTRnovel0.67
BLCAchr1154598431Missense_MutationnovelH586Y0.2
BLCAchr1154598407Frame_Shift_InsnovelE594Sfs*800.18
BLCAchr1154584820Missense_MutationNAL1223V0.28
BLCAchr1154598548Missense_MutationNAP547S0.07
BLCAchr1154590304Missense_MutationnovelL792F0.13
BLCAchr1154602294Missense_MutationnovelR116S0.1
BLCAchr1154602370Missense_MutationnovelR91K0.19
BLCAchr11545846753'UTRnovel0.24
BLCAchr1154589438Missense_MutationNAS898F0.28z-alpha
BRCAchr1154585329Missense_MutationNAI1111L0.3z-alpha
BRCAchr1154589458SilentnovelN891N0.08
BRCAchr1154588615Missense_MutationnovelE941Q0.17z-alpha
BRCAchr1154602610Missense_MutationnovelG11V0.15
BRCAchr1154601154SilentnovelL496L0.07
BRCAchr1154588251Missense_MutationnovelP965T0.13z-alpha
BRCAchr1154589438Missense_MutationNAS898C0.18z-alpha
BRCAchr1154585010Missense_MutationNAK1159N0.11z-alpha
BRCAchr1154589455SilentNAR892R0.28
CESCchr1154586363Missense_MutationNAG1007A0.49z-alpha
CESCchr1154588151Missense_MutationNAG998A0.34z-alpha
CESCchr1154601044Missense_MutationnovelP533H0.37
CESCchr11545846963'UTRnovel0.36
CESCchr1154585781Missense_Mutationrs747462052R1096Q0.37z-alpha
CESCchr1154590212Nonsense_MutationNAS823*0.2
CESCchr1154602487Missense_MutationNAP52L0.39
COADchr1154588162SilentnovelN994N0.13
COADchr1154602002Missense_MutationNAD214N0.33
COADchr1154590380Missense_MutationNAR767L0.44
COADchr1154602509Missense_MutationnovelE45Q0.37
COADchr1154584830Missense_MutationnovelK1219N0.36
COADchr1154601308Missense_MutationnovelG445V0.25
COADchr1154602357Missense_MutationnovelR95S0.22
COADchr1154589790Missense_MutationnovelE879K0.09
COADchr11545846023'UTRnovel0.41
COADchr1154585268Missense_MutationnovelA1131V0.13z-alpha
COADchr1154601967Silentrs771459105P225P0.37
COADchr11545847833'UTRnovel0.27
COADchr1154584910Missense_MutationnovelE1193K0.17z-alpha
COADchr1154602620Missense_MutationNAS8T0.23
COADchr1154602287Missense_MutationNAP119S0.42
COADchr1154602383Nonsense_MutationnovelQ87*0.14
COADchr1154602325Missense_MutationNAR106K0.19
COADchr1154602373Missense_MutationNAI90S0.13
COADchr1154588632Missense_Mutationrs767879893A935V0.31z-alpha
COADchr1154601100Silentrs757137562F514F0.32
COADchr1154601750Missense_Mutationrs755166511E298K0.35
ESCAchr11545820793'UTRnovel0.18
ESCAchr1154601108Missense_MutationnovelA512P0.45
ESCAchr1154590279Missense_Mutationrs748161184R801C0.4
ESCAchr1154585825SilentnovelC1081C0.47
ESCAchr1154602313Missense_MutationnovelH110R0.2
GBMchr1154601180Frame_Shift_DelnovelL487Ffs*290.05
GBMchr1154601115Frame_Shift_DelnovelL509*0.17
GBMchr1154602071Missense_MutationnovelT191S0.04
GBMchr1154602224Missense_MutationnovelE140K0.5
GBMchr1154589442Missense_MutationnovelD897H0.11z-alpha
GBMchr1154601824Missense_MutationnovelD273V0.11
GBMchr11545847263'UTRnovel0.23
GBMchr1154586361Missense_MutationnovelE1008K0.37z-alpha
GBMchr1154590361Silentrs750666914C773C0.05
GBMchr1154601837Missense_MutationnovelS269T0.05
GBMchr1154601838SilentnovelG268G0.05
HNSCchr1154584906Missense_Mutationrs367899281T1194M0.18z-alpha
HNSCchr1154602217Missense_MutationnovelR142K0.27
HNSCchr1154589895Missense_MutationnovelI844V0.57
HNSCchr1154596843Missense_MutationnovelF744L0.11
HNSCchr1154601064SilentNAQ526Q0.15
HNSCchr1154589438Missense_MutationNAS898C0.24z-alpha
HNSCchr1154602124Missense_Mutationrs201331183N173S0.22
KIRCchr1154601770Missense_MutationNAL291P0.33
KIRCchr1154601716Missense_MutationNAN309I0.34
KIRCchr1154602211Nonsense_MutationNAL144*0.3
KIRCchr1154601686Missense_MutationNAA319D0.25
KIRPchr1154602244Missense_MutationNAL133Q0.23
KIRPchr1154602265Missense_MutationNAL126P0.58
LAMLchr1154601369Missense_MutationNAA425T0.1
LAMLchr1154596853Missense_MutationnovelA741G0.26
LGGchr1154590187SilentnovelK831K0.46
LGGchr1154601644Missense_MutationnovelV333G0.37
LIHCchr1154597269Splice_SiteNAX645_splice0.46
LIHCchr1154601115SilentNAL509L0.33
LIHCchr1154588663Missense_MutationnovelS925C0.12z-alpha
LUADchr1154588548Splice_Regionnovel0.1
LUADchr1154586317Missense_MutationNAW1022C0.3z-alpha
LUADchr1154602544Missense_MutationNAG33A0.24
LUADchr1154590250SilentnovelV810V0.18
LUADchr1154598586Splice_SitenovelX534_splice0.1
LUADchr1154585790Missense_MutationnovelD1093V0.16z-alpha
LUADchr1154585791Missense_MutationnovelD1093N0.16z-alpha
LUADchr1154602537SilentnovelS35S0.21
LUADchr1154584822Missense_MutationnovelY1222C0.19
LUADchr1154598586Splice_SiteNAX534_splice0.12
LUADchr1154601237Missense_MutationnovelA469T0.09
LUADchr1154588557Missense_MutationNAY960C0.23z-alpha
LUADchr1154601853Silentrs773658109D263D0.17
LUADchr1154601166SilentNAP492P0.07
LUSCchr1154601858Missense_MutationnovelP262S0.15
LUSCchr1154602152Nonsense_MutationNAK164*0.43
LUSCchr1154602334Missense_MutationNAG103E0.43
LUSCchr1154601753Missense_MutationNAA297S0.27
LUSCchr1154589884SilentnovelL847L0.1
LUSCchr1154585782SilentnovelR1096R0.55
LUSCchr1154601997SilentnovelG215G0.13
LUSCchr1154584978Missense_MutationnovelS1170F0.29z-alpha
LUSCchr1154602618SilentnovelS8S0.25
LUSCchr1154601792Missense_MutationNAT284A0.33
LUSCchr1154589922Missense_MutationnovelL835V0.14
LUSCchr1154601792Missense_MutationNAT284A0.14
LUSCchr11545847513'UTRnovel0.1
LUSCchr1154602594SilentNAP16P0.65
LUSCchr1154602327Missense_MutationNAQ105H0.44
LUSCchr1154601600Missense_MutationnovelT348A0.11
LUSCchr1154602322Missense_MutationnovelG107E0.18
OVchr1154589918Missense_MutationNAT836I0.4
OVchr1154601687Missense_MutationNAA319S0.35
OVchr1154601581Missense_MutationnovelH354L0.18
OVchr1154601906Missense_MutationnovelI246V0.05
OVchr1154590340SilentnovelG780G0.04
OVchr1154586267Missense_MutationNAK1039R0.23z-alpha
OVchr1154602353Missense_Mutationrs750065985V97M0.11
OVchr1154601893Missense_MutationNAA250V0.11
OVchr1154602332Missense_MutationnovelL104V0.05
OVchr1154601697Nonsense_MutationnovelA315_L316insDL*AVLFGG0.24
PAADchr1154598464Missense_MutationnovelA575S0.13
PAADchr1154597188Missense_MutationnovelA672T0.15
PAADchr1154602051Silentrs202096621I197I0.24
PAADchr1154602548Missense_MutationnovelP32S0.21
PRADchr1154585240SilentNAD1140D0.11
PRADchr1154584966Missense_MutationNAR1174H0.34z-alpha
READchr1154588168Silentrs552926126F992F0.14
READchr1154585862Missense_MutationnovelY1069S0.07z-alpha
READchr1154589456Missense_Mutationrs398122892R892H0.41z-alpha
READchr1154601079Missense_MutationnovelF521L0.05
READchr1154601900Missense_MutationnovelV248I0.44
READchr1154602237SilentNAI135I0.41
READchr1154597948Nonsense_MutationNAS605*0.44
SARCchr1154601515Missense_MutationnovelA376D0.13
SARCchr11545847053'UTRnovel0.17
SARCchr1154596936SilentnovelV713V0.13
SARCchr11545820793'UTRnovel0.38
SARCchr11545846963'UTRnovel0.55
SARCchr1154589884SilentnovelL847L0.24
SKCMchr1154590312Missense_MutationnovelR790C0.74
SKCMchr1154602109Missense_MutationNAS178F0.19
SKCMchr1154602595Missense_MutationnovelP16L0.14
SKCMchr1154589444Missense_MutationnovelG896E0.41z-alpha
SKCMchr1154589445Missense_MutationnovelG896R0.39z-alpha
SKCMchr1154596954SilentnovelS707S0.21
SKCMchr1154601222Nonsense_Mutationrs121912421R474*0.54
SKCMchr1154590381Missense_MutationNAR767C0.26
SKCMchr1154585025Silentrs758253421S1154S0.46
SKCMchr1154601457SilentNAP395P0.5
SKCMchr11545846033'UTRnovel0.5
SKCMchr1154602108SilentnovelS178S0.31
SKCMchr1154602109Missense_MutationNAS178F0.3
SKCMchr1154585245SilentNAL1139L0.47
SKCMchr1154597938Silentrs368530348S608S0.37
SKCMchr1154602180SilentNAK154K0.44
SKCMchr1154601502SilentnovelI380I0.34
SKCMchr1154596955Missense_MutationNAS707F0.42
SKCMchr1154601051Missense_MutationNAH531Y0.09
SKCMchr1154602051Silentrs202096621I197I0.28
SKCMchr1154588144SilentNAL1000L0.23
SKCMchr1154586263Silentrs771995348I1040I0.48
SKCMchr1154589444Missense_MutationnovelG896A0.19z-alpha
SKCMchr1154586263Silentrs771995348I1040I0.22
SKCMchr1154597231SilentnovelF657F0.22
STADchr1154590366Missense_Mutationrs763229776V772I0.21
STADchr1154589892Missense_MutationNAA845T0.07
STADchr11545846963'UTRnovel0.3
STADchr11545846963'UTRnovel0.3
STADchr11545846963'UTRnovel0.44
STADchr1154585039Missense_MutationNAR1150W0.29z-alpha
STADchr1154584911Silentrs768173047Y1192Y0.62
STADchr11545846963'UTRnovel0.18
STADchr1154597181Missense_MutationNAE674G0.13
STADchr1154597917Frame_Shift_DelnovelV616Sfs*450.14
STADchr1154584954Missense_MutationnovelL1178P0.2z-alpha
STADchr1154602426SilentnovelR72R0.26
STADchr11545846963'UTRnovel0.34
STADchr1154588185Missense_Mutationrs763536266R987C0.31z-alpha
STADchr1154584884Frame_Shift_DelnovelG1202Afs*20.21z-alpha
STADchr11545846963'UTRnovel0.21
STADchr1154602249SilentNAQ131Q0.36
STADchr1154588578Missense_MutationNAK953R0.24z-alpha
STADchr1154602301Missense_Mutationrs770167108R114H0.16
STADchr1154597916Missense_Mutationrs570647049V616I0.38
STADchr11545846963'UTRnovel0.3
STADchr1154602517Missense_MutationNAK42R0.26
STADchr11545846963'UTRnovel0.42
STADchr1154602488Missense_MutationnovelP52S0.4
STADchr1154596956Missense_MutationNAS707T0.12
STADchr11546278855'UTRnovel0.29
STADchr1154598544Frame_Shift_DelnovelP548Qfs*160.2
STADchr1154602215Missense_MutationNAI143F0.22
THCAchr1154601947Missense_MutationNAR232K0.27
THYMchr1154601357Missense_MutationnovelP429T0.1
UCECchr11545847093'UTRnovel0.44
UCECchr11545847113'UTRnovel0.34
UCECchr1154586259Missense_Mutationrs779004315R1042C0.12z-alpha
UCECchr1154585825SilentnovelC1081C0.16
UCECchr1154597916Missense_Mutationrs570647049V616I0.12
UCECchr11545820793'UTRnovel0.33
UCECchr1154585831SilentnovelA1079A0.35
UCECchr1154601563Missense_Mutationrs149091481R360Q0.48
UCECchr1154588213Silentrs140462815S977S0.28
UCECchr1154586307Missense_Mutationrs374300359R1026W0.38z-alpha
UCECchr1154598576Missense_MutationnovelF537L0.04
UCECchr11545846963'UTRnovel0.3
UCECchr11545821963'UTRnovel0.33
UCECchr1154588126Splice_Regionrs151241634N1006N0.37
UCECchr1154601283Silentrs751114722Q453Q0.52
UCECchr1154596813Silentrs779685414H754H0.36
UCECchr1154588575Missense_MutationnovelT954N0.48z-alpha
UCECchr1154596859Missense_MutationnovelG739D0.44
UCECchr1154597963Missense_MutationnovelQ600R0.31
UCECchr1154598446Missense_MutationnovelS581A0.14
UCECchr1154602505Missense_MutationnovelF46C0.18
UCECchr11545846273'UTRnovel0.33
UCECchr1154584826Missense_MutationNAF1221I0.24
UCECchr1154589393Missense_MutationnovelI913T0.09z-alpha
UCECchr1154601647Missense_MutationNAA332D0.23
UCECchr11545846963'UTRnovel0.32
UCECchr11545846963'UTRnovel0.17
UCECchr11545847053'UTRnovel0.5
UCECchr11545822503'UTRnovel0.58
UCECchr1154601730Silentrs374863496C304C0.08
UCECchr1154602049Missense_Mutationrs760911897A198V0.15
UCECchr11545820793'UTRnovel0.48
UCECchr1154601712SilentNAV310V0.44
UCECchr1154602457Missense_MutationNAP62Q0.31
UCECchr11545820793'UTRnovel0.45
UCECchr11545846963'UTRnovel0.26
UCECchr1154602524Missense_MutationnovelL40M0.31
UCECchr1154588143Missense_MutationnovelR1001C0.31z-alpha
UCECchr1154597137Missense_MutationnovelA689S0.1
UCECchr1154597825Splice_Regionnovel0.17
UCECchr1154602329Nonsense_MutationnovelQ105*0.3
UCECchr1154596812Missense_Mutationrs758150130E755K0.48
UCECchr1154589796Frame_Shift_InsnovelD877Rfs*30.15
UCECchr1154598493Missense_MutationnovelA565V0.47
UCECchr1154601536Missense_MutationnovelT369M0.38
UCECchr11545846963'UTRnovel0.17
UCECchr1154590406Silentrs149039619F758F0.44
UCECchr1154598445Nonsense_MutationnovelS581*0.41
UCECchr1154588648Missense_MutationnovelY930H0.3z-alpha
UCECchr1154601582Missense_Mutationrs186852211H354Y0.39
UCECchr1154590279Missense_MutationnovelR801S0.13
UCECchr1154585285Silentrs774730059S1125S0.2
UCECchr1154588560Missense_MutationnovelL959R0.38z-alpha
UCECchr11545846963'UTRnovel0.39
UCECchr11545820823'UTRnovel0.27
UCECchr1154601563Missense_Mutationrs149091481R360Q0.34
UCECchr11545846963'UTRnovel0.27
UCECchr11545820793'UTRnovel0.27
UCECchr1154601141Silentrs758025779L501L0.06
UCECchr1154602579SilentNAE21E0.14
UCECchr11545846963'UTRnovel0.52
UCECchr1154602477Silentrs570176840P55P0.34
UCECchr1154602457Missense_MutationnovelP62R0.52
UCECchr11545820793'UTRnovel0.26
UCECchr11545846963'UTRnovel0.17
UCECchr1154588609Missense_MutationnovelA943T0.47z-alpha
UCECchr1154601998Missense_Mutationrs139492641G215D0.36
UCECchr1154601273Missense_MutationnovelD457Y0.08
UCECchr11545822503'UTRnovel0.52
UCECchr11545845333'UTRnovel0.4
UCECchr11545846903'UTRnovel0.26
UCECchr1154585852SilentnovelS1072S0.24
UCECchr11546278655'UTRnovel0.22
UCECchr1154601100Silentrs757137562F514F0.43
UCECchr1154588649Missense_MutationnovelK929N0.33z-alpha
UCECchr1154601652Missense_MutationnovelI330M0.44
UCECchr1154602354Silentrs779403614G96G0.39
UCECchr1154589794SilentNAD877D0.17
UCECchr1154602420Silentrs150423721R74R0.05
UCECchr1154585825SilentnovelC1081C0.41
UCECchr1154602333Silentrs141224623G103G0.43
UCECchr1154602503Missense_MutationnovelL47I0.55
UCECchr1154601730Silentrs374863496C304C0.36
UCECchr1154602478Missense_Mutationrs187076847P55L0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.14440.11282
CESCAMP0.48473.2002e-05
DLBCDEL0.02080.0017831
ESCAAMP0.38590.0022446
KIRCAMP0.09280.059566
PAADAMP0.22830.085665
PCPGAMP0.14810.00029562
PRADAMP0.07720.00077815
READAMP0.26670.025154
SKCMAMP0.49599.6912e-06
TGCTAMP0.34670.088103

Survival Analysis
CancerP-value Q-value
THYM0.048

Kaplan-Meier Survival Analysis

ACC0.0052

Kaplan-Meier Survival Analysis

SKCM0.041

Kaplan-Meier Survival Analysis

PRAD0.025

Kaplan-Meier Survival Analysis

KIRP0.0035

Kaplan-Meier Survival Analysis

PCPG0.038

Kaplan-Meier Survival Analysis

BLCA0.049

Kaplan-Meier Survival Analysis

KICH0.013

Kaplan-Meier Survival Analysis

UCEC0.023

Kaplan-Meier Survival Analysis

LIHC0.00075

Kaplan-Meier Survival Analysis

LGG0.00028

Kaplan-Meier Survival Analysis

LUAD0.031

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000160710 (Gene tree)
Gene ID
103
Gene Symbol
ADAR
Alias
ADAR1|IFI4|G1P1
Full Name
adenosine deaminase RNA specific
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
45,957 bases
Position
chr1:154,582,057-154,628,013
Accession
225
RBP type
canonical RBP
Summary
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000496896z-alphaPF02295.172.8e-5712
ENSP00000496896z-alphaPF02295.172.8e-5722
ENSP00000431794z-alphaPF02295.173.1e-5712
ENSP00000431794z-alphaPF02295.173.1e-5722
ENSP00000357459z-alphaPF02295.173.3e-5712
ENSP00000357459z-alphaPF02295.173.3e-5722
ENSP00000497276z-alphaPF02295.173.3e-5712
ENSP00000497276z-alphaPF02295.173.3e-5722
ENSP00000497793z-alphaPF02295.172.9e-2611
ENSP00000357456z-alphaPF02295.171e-2511
ENSP00000497210z-alphaPF02295.171e-2511
ENSP00000497555z-alphaPF02295.171e-2511
ENSP00000497589z-alphaPF02295.171e-2511
ENSP00000497790z-alphaPF02295.171e-2511
ENSP00000497932z-alphaPF02295.171e-2511
ENSP00000498137z-alphaPF02295.171e-2511
ENSP00000357456dsrmPF00035.261.6e-3413
ENSP00000357456dsrmPF00035.261.6e-3423
ENSP00000357456dsrmPF00035.261.6e-3433
ENSP00000497210dsrmPF00035.261.6e-3413
ENSP00000497210dsrmPF00035.261.6e-3423
ENSP00000497210dsrmPF00035.261.6e-3433
ENSP00000497555dsrmPF00035.261.6e-3413
ENSP00000497555dsrmPF00035.261.6e-3423
ENSP00000497555dsrmPF00035.261.6e-3433
ENSP00000497589dsrmPF00035.261.6e-3413
ENSP00000497589dsrmPF00035.261.6e-3423
ENSP00000497589dsrmPF00035.261.6e-3433
ENSP00000497790dsrmPF00035.261.6e-3413
ENSP00000497790dsrmPF00035.261.6e-3423
ENSP00000497790dsrmPF00035.261.6e-3433
ENSP00000497932dsrmPF00035.261.6e-3413
ENSP00000497932dsrmPF00035.261.6e-3423
ENSP00000497932dsrmPF00035.261.6e-3433
ENSP00000498137dsrmPF00035.261.6e-3413
ENSP00000498137dsrmPF00035.261.6e-3423
ENSP00000498137dsrmPF00035.261.6e-3433
ENSP00000496896dsrmPF00035.263.7e-3413
ENSP00000496896dsrmPF00035.263.7e-3423
ENSP00000496896dsrmPF00035.263.7e-3433
ENSP00000431794dsrmPF00035.264.2e-3413
ENSP00000431794dsrmPF00035.264.2e-3423
ENSP00000431794dsrmPF00035.264.2e-3433
ENSP00000357459dsrmPF00035.264.5e-3413
ENSP00000357459dsrmPF00035.264.5e-3423
ENSP00000357459dsrmPF00035.264.5e-3433
ENSP00000497276dsrmPF00035.264.5e-3413
ENSP00000497276dsrmPF00035.264.5e-3423
ENSP00000497276dsrmPF00035.264.5e-3433
ENSP00000497793dsrmPF00035.264.2e-1511
ENSP00000357456A_deaminPF02137.181.4e-10911
ENSP00000497210A_deaminPF02137.181.4e-10911
ENSP00000497555A_deaminPF02137.181.4e-10911
ENSP00000497589A_deaminPF02137.181.4e-10911
ENSP00000497790A_deaminPF02137.181.4e-10911
ENSP00000497932A_deaminPF02137.181.4e-10911
ENSP00000498137A_deaminPF02137.181.4e-10911
ENSP00000496896A_deaminPF02137.182.2e-10911
ENSP00000431794A_deaminPF02137.182.4e-10911
ENSP00000357459A_deaminPF02137.182.5e-10911
ENSP00000497276A_deaminPF02137.182.5e-10911
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12773480The dsRNA binding protein family: critical roles, diverse cellular functions.FASEB J2003 JunSaunders LR-
25172485Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.J Immunol2014 Oct 1Yang Sdoi: 10.4049/jimmunol.1401136
9738463The double-stranded RNA-binding domains of Xenopus laevis ADAR1 exhibit different RNA-binding behaviors.FEBS Lett1998 Aug 28Brooks R-
11070079Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR.Proc Natl Acad Sci U S A2000 Nov 7Liu Y-
17000903RNA aptamers binding the double-stranded RNA-binding domain.RNA2006 NovHallegger M-
21490091Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase.J Virol2011 SepGelinas JFdoi: 10.1128/JVI.00240-11
20863128Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs.ACS Chem Biol2010 Dec 17Peacock Hdoi: 10.1021/cb100245u
24753571A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.Proc Natl Acad Sci U S A2014 May 6Barraud Pdoi: 10.1073/pnas.1323698111
11689059Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity.Virology2001 Oct 25Liu Y-
9988754Editing of glutamate receptor subunit B pre-mRNA by splice-site variants of interferon-inducible double-stranded RNA-specific adenosine deaminase ADAR1.J Biol Chem1999 Feb 19Liu Y-
8627722Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase.J Virol1996 MarLiu Y-
7972084Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.Proc Natl Acad Sci U S A1994 Nov 22Kim U-
12719472Distinct in vivo roles for double-stranded RNA-binding domains of the Xenopus RNA-editing enzyme ADAR1 in chromosomal targeting.J Cell Biol2003 Apr 28Doyle M-
12429827Nucleocytoplasmic distribution of human RNA-editing enzyme ADAR1 is modulated by double-stranded RNA-binding domains, a leucine-rich export signal, and a putative dimerization domain.Mol Biol Cell2002 NovStrehblow A-
15843431Chromosomal storage of the RNA-editing enzyme ADAR1 in Xenopus oocytes.Mol Biol Cell2005 JulSallacz NB-
19124606RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.Mol Cell Biol2009 MarFritz Jdoi: 10.1128/MCB.01519-08
25064266HIV-1 translation and its regulation by cellular factors PKR and PACT.Virus Res2014 Nov 26Burugu Sdoi: 10.1016/j.virusres.2014.07.014
25926645New Noncoding Lytic Transcripts Derived from the Epstein-Barr Virus Latency Origin of Replication, oriP, Are Hyperedited, Bind the Paraspeckle Protein, NONO/p54nrb, and Support Viral Lytic Transcription.J Virol2015 JulCao Sdoi: 10.1128/JVI.00608-15
27040499TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins.Cell2016 Apr 21McMahon ACdoi: 10.1016/j.cell.2016.03.007
23728176MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.J Clin Invest2013 JunNemlich Y-
28984845Site-directed RNA editing by adenosine deaminase acting on RNA for correction of the genetic code in gene therapy.Gene Ther2017 DecAzad MTAdoi: 10.1038/gt.2017.90
30426900Comparative Activity of Adenosine Deaminase Acting on RNA (ADARs) Isoforms for Correction of Genetic Code in Gene Therapy.Curr Gene Ther2019Azad MTAdoi: 10.2174/1566523218666181114122116.
10373439Serotonin-2C receptor pre-mRNA editing in rat brain and in vitro by splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase ADAR1.J Biol Chem1999 Jun 25Liu Y-
12954622Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation.J Biol Chem2003 Nov 14Yang JH-
9735305Double-stranded RNA-specific adenosine deaminase: nucleic acid binding properties.Methods1998 JulLiu Y-
9636358Adenovirus VAI RNA antagonizes the RNA-editing activity of the ADAR adenosine deaminase.Virology1998 Jun 5Lei M-
10376681Editing of messenger RNA precursors and of tRNAs by adenosine to inosine conversion.FEBS Lett1999 Jun 4Keller W-
12453429Induction of protein translation by ADAR1 within living cell nuclei is not dependent on RNA editing.Mol Cell2002 NovHerbert A-
11451992The human but not the Xenopus RNA-editing enzyme ADAR1 has an atypical nuclear localization signal and displays the characteristics of a shuttling protein.Mol Biol Cell2001 JulEckmann CR-
11421361Substrate recognition by ADAR1 and ADAR2.RNA2001 JunWong SK-
16177183Modulation of ADAR1 editing activity by Z-RNA in vitro.Nucleic Acids Res2005 Sep 21Koeris M-
15556947ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells.J Biol Chem2005 Feb 4Yang W-
19713932Editing independent effects of ADARs on the miRNA/siRNA pathways.EMBO J2009 Oct 21Heale BSdoi: 10.1038/emboj.2009.244
19605474ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.J Virol2009 OctClerzius Gdoi: 10.1128/JVI.02457-08
25708366ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner.Cell Res2015 AprChen Tdoi: 10.1038/cr.2015.24
24393560Mammalian conserved ADAR targets comprise only a small fragment of the human editosome.Genome Biol2014 Jan 7Pinto Ydoi: 10.1186/gb-2014-15-1-r5.
24020926The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.Retrovirology2013 Sep 11Clerzius Gdoi: 10.1186/1742-4690-10-96.
27256387Controlling the Editor: The Many Roles of RNA-Binding Proteins in Regulating A-to-I RNA Editing.Adv Exp Med Biol2016Washburn MCdoi: 10.1007/978-3-319-29073-7_8.
25826567Diverse selective regimes shape genetic diversity at ADAR genes and at their coding targets.RNA Biol2015Forni Ddoi: 10.1080/15476286.2015.1017215.
28925356The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis.Elife2017 Sep 19Deffit SNdoi: 10.7554/eLife.28625.
28960389The Other Face of an Editor: ADAR1 Functions in Editing-Independent Ways.Bioessays2017 NovLicht Kdoi: 10.1002/bies.201700129
29127211Mechanistic implications of enhanced editing by a HyperTRIBE RNA-binding protein.RNA2018 FebXu Wdoi: 10.1261/rna.064691.117
29694248ADAR1 attenuates allogeneic graft rejection by suppressing miR-21 biogenesis in macrophages and promoting M2 polarization.FASEB J2018 SepLi Jdoi: 10.1096/fj.201701449R
29775506Dyschromatosis symmetrica hereditaria with chilblains due to a novel two-amino-acid deletion in the double-stranded RNA-binding domain of ADAR1.J Eur Acad Dermatol Venereol2018 OctKono Mdoi: 10.1111/jdv.15076
30592616NMR Dynamics Study Reveals the Z-and-alpha; Domain of Human ADAR1 Associates with and Dissociates from Z-RNA More Slowly than Z-DNA.ACS Chem Biol2019 Feb 15Lee ARdoi: 10.1021/acschembio.8b00914
30651363Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication.J Virol2019 Mar 21Liao GRdoi: 10.1128/JVI.01912-18
31018137Disruption in A-to-I Editing Levels Affects C.elegans Development More Than a Complete Lack of Editing.Cell Rep2019 Apr 23Ganem NSdoi: 10.1016/j.celrep.2019.03.095.
17054412An artificial neural network approach to the drug efficacy of interferon treatments.Pharmacogenomics2006 OctLin E-
17979507Gene-gene and gene-environment interactions in interferon therapy for chronic hepatitis C.Pharmacogenomics2007 OctLin E-
17079286Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.J Virol2007 JanNie Y-
22104209ADAR1 is a novel multi targeted anti-HIV-1 cellular protein.Virology2012 Jan 20Biswas Ndoi: 10.1016/j.virol.2011.10.024
25921533Cis regulatory effects on A-to-I RNA editing in related Drosophila species.Cell Rep2015 May 5Sapiro ALdoi: 10.1016/j.celrep.2015.04.005
29691780Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.Dig Dis Sci2018 JulCho CJdoi: 10.1007/s10620-018-5081-9
30013039Identification of RNA-binding protein targets with HyperTRIBE.Nat Protoc2018 AugRahman Rdoi: 10.1038/s41596-018-0020-y.
28575488A deep boosting based approach for capturing the sequence binding preferences of RNA-binding proteins from high-throughput CLIP-seq data.Nucleic Acids Res2017 Aug 21Li Sdoi: 10.1093/nar/gkx492.
17224799Adenosine deaminase acting on RNA 1 accelerates cell cycle through increased translation and activity of cyclin-dependent kinase 2.Shock2007 FebZhang F-
26184879Dynamic profiling of double-stranded RNA binding proteins.Nucleic Acids Res2015 Sep 3Wang Xdoi: 10.1093/nar/gkv726
29364877Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation.Nature2018 Feb 1Shen Qdoi: 10.1038/nature25434
11230159Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.Genome Res2001 MarMarenholz I-
16886895Genetic predisposition of responsiveness to therapy for chronic hepatitis C.Pharmacogenomics2006 JulHwang Y-
28924040A B-Z junction induced by an A...A mismatch in GAC repeats in the gene for cartilage oligomeric matrix protein promotes binding with the hZ-and-alpha;ADAR1 protein.J Biol Chem2017 Nov 17Kolimi Ndoi: 10.1074/jbc.M117.796235
28985428An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.Nucleic Acids Res2017 Oct 13Qi Ldoi: 10.1093/nar/gkx667.
10535945The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.Proc Natl Acad Sci U S A1999 Oct 26Schade M-
9889202Structure-function analysis of the Z-DNA-binding domain Zalpha of dsRNA adenosine deaminase type I reveals similarity to the (alpha + beta) family of helix-turn-helix proteins.EMBO J1999 Jan 15Schade M-
9671809The Zalpha domain from human ADAR1 binds to the Z-DNA conformer of many different sequences.Nucleic Acids Res1998 Aug 1Herbert A-
8595560Deamination of mammalian glutamate receptor RNA by Xenopus dsRNA adenosine deaminase: similarities to in vivo RNA editing.RNA1995 DecHurst SR-
7615504Mutagenic analysis of double-stranded RNA adenosine deaminase, a candidate enzyme for RNA editing of glutamate-gated ion channel transcripts.J Biol Chem1995 Jul 21Lai F-
11842111Complex regulation of the human gene for the Z-DNA binding protein DLM-1.Nucleic Acids Res2002 Feb 15Rothenburg S-
11524677Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.Nat Struct Biol2001 SepSchwartz T-
19276205Human genomic Z-DNA segments probed by the Z alpha domain of ADAR1.Nucleic Acids Res2009 MayLi Hdoi: 10.1093/nar/gkp124
17268113Identification of novel ligands for the Z-DNA binding protein by structure-based virtual screening.Chem Pharm Bull (Tokyo)2007 FebKim YG-
20439751Crystal structure of a junction between two Z-DNA helices.Proc Natl Acad Sci U S A2010 May 18de Rosa Mdoi: 10.1073/pnas.1003182107
25344900Understanding the recognition mechanisms of Z-and-alpha; domain of human editing enzyme ADAR1 (hZ-and-alpha;(ADAR1)) and various Z-DNAs from molecular dynamics simulation.J Mol Model2014 NovWang Qdoi: 10.1007/s00894-014-2500-5
24719423hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication.J Virol2014 JulLi Ydoi: 10.1128/JVI.00225-14
24067935ADAR1 regulates ARHGAP26 gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding.RNA2013 NovWang Qdoi: 10.1261/rna.041533.113
27112566Adenosine to Inosine editing frequency controlled by splicing efficiency.Nucleic Acids Res2016 Jul 27Licht Kdoi: 10.1093/nar/gkw325
25751603Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways.Nat Commun2015 Mar 9Bahn JHdoi: 10.1038/ncomms7355.
29395325Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.Cell2018 Feb 8Chung Hdoi: 10.1016/j.cell.2017.12.038
29950133Base-pairing probability in the microRNA stem region affects the binding and editing specificity of human A-to-I editing enzymes ADAR1-p110 and ADAR2.RNA Biol2018Ishiguro Sdoi: 10.1080/15476286.2018.1486658
30304469The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Z-and-alpha; DNA-binding activity.Nucleic Acids Res2018 Dec 14Lee CHdoi: 10.1093/nar/gky933.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000648714ADAR-2156005-ENSP00000497434707 (aa)--
ENST00000526905ADAR-207302--- (aa)--
ENST00000649021ADAR-2177112--- (aa)--
ENST00000494866ADAR-206471--- (aa)--
ENST00000649042ADAR-2196263XM_006711111ENSP00000497790931 (aa)XP_006711174UPI0000458ADB
ENST00000463920ADAR-2032347--- (aa)--
ENST00000530954ADAR-209558--- (aa)--
ENST00000529168ADAR-2086343-ENSP000004317941200 (aa)-H0YCK3
ENST00000647597ADAR-2116667-ENSP000004972761226 (aa)-UPI000045626B
ENST00000649593ADAR-2216537XM_011509061ENSP00000497589931 (aa)XP_011507363UPI0000458ADB
ENST00000368471ADAR-2016519XM_006711113ENSP00000357456931 (aa)XP_006711176P55265
ENST00000648871ADAR-2161619-ENSP00000497793350 (aa)--
ENST00000649408ADAR-2201797-ENSP00000497386164 (aa)--
ENST00000647682ADAR-2122548--- (aa)--
ENST00000649724ADAR-2226425XM_006711109ENSP00000497932931 (aa)-UPI0000458ADB
ENST00000648311ADAR-2146539-ENSP00000498137931 (aa)-UPI0000458ADB
ENST00000534279ADAR-210849--- (aa)--
ENST00000492630ADAR-205612--- (aa)--
ENST00000649749ADAR-2236412-ENSP00000497210931 (aa)-UPI0000458ADB
ENST00000648231ADAR-2136700-ENSP00000497555931 (aa)-UPI0000458ADB
ENST00000471068ADAR-204583--- (aa)--
ENST00000649022ADAR-2185270-ENSP000004968961158 (aa)--
ENST00000368474ADAR-2026610-ENSP000003574591226 (aa)-P55265
Gene Model
Click here to download ENSG00000160710's gene model file
Pathways
Pathway IDPathway NameSource
hsa04623Cytosolic DNA-sensing pathwayKEGG
hsa05162MeaslesKEGG
hsa05164Influenza AKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000160710Blood Pressure8.42420657511962E-517903303
ENSG00000160710Asthma8.5012340E-006-
ENSG00000160710Asthma2.8281620E-005-
ENSG00000160710Platelet Function Tests2.2204460E-016-
ENSG00000160710Receptors, Interleukin-61.7210000E-007-
ENSG00000160710Receptors, Interleukin-63.2510000E-006-
ENSG00000160710Receptors, Interleukin-69.1550000E-006-
ENSG00000160710Receptors, Interleukin-63.7430000E-007-
ENSG00000160710Receptors, Interleukin-66.0500000E-006-
ENSG00000160710Receptors, Interleukin-61.7210000E-007-
ENSG00000160710Receptors, Interleukin-66.6390000E-007-
ENSG00000160710C-Reactive Protein6E-927286809
ENSG00000160710Triglycerides6E-927286809
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000160710rs780625881154593749TLung cancer28604730[1.08-1.19]1.1326951EFO_0001071
ENSG00000160710rs11273111154584187AC-reactive protein levels or triglyceride levels (pleiotropy)27286809EFO_0004530|EFO_0004458
ENSG00000160710rs37380301154602839?General cognitive ability29844566z-score increase5.044EFO_0004337
ENSG00000160710rs613003921154603209TAge of smoking initiation (MTAG)30643251[0.0099-0.0206] unit increase0.0152515EFO_0005670
ENSG00000160710rs780625881154593749CSmoking initiation (ever regular vs never regular) (MTAG)30643251[0.0085-0.0166] unit decrease0.0125545EFO_0006527
ENSG00000160710rs96161154583257?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160710's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000160710ADAR5137.500ENSG00000140955ADAD27930.631
ENSG00000160710ADAR7442.424ENSG00000197381ADARB16536.701
ENSG00000160710ADAR7539.683ENSG00000185736ADARB28731.618
ENSG00000160710ADAR6832.432ENSG00000065457ADAT16332.579
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000160710ADAR7573.984ENSAPOG00000023804adar9145.072Acanthochromis_polyacanthus
ENSG00000160710ADAR10087.017ENSAMEG00000011594ADAR9978.904Ailuropoda_melanoleuca
ENSG00000160710ADAR10044.928ENSACIG00000008672adar7052.857Amphilophus_citrinellus
ENSG00000160710ADAR7573.984ENSAOCG00000020750adar9144.591Amphiprion_ocellaris
ENSG00000160710ADAR7573.984ENSAPEG00000004762adar9145.259Amphiprion_percula
ENSG00000160710ADAR7575.610ENSATEG00000023684adar9145.070Anabas_testudineus
ENSG00000160710ADAR9957.862ENSAPLG00000009658ADAR9952.216Anas_platyrhynchos
ENSG00000160710ADAR7363.729ENSACAG00000025913-7560.127Anolis_carolinensis
ENSG00000160710ADAR5069.512ENSACAG00000015640-10059.759Anolis_carolinensis
ENSG00000160710ADAR10096.241ENSANAG00000007524ADAR10096.241Aotus_nancymaae
ENSG00000160710ADAR7575.610ENSACLG00000019448adar7947.340Astatotilapia_calliptera
ENSG00000160710ADAR7575.610ENSAMXG00000016460adar8146.889Astyanax_mexicanus
ENSG00000160710ADAR10088.412ENSBTAG00000007519ADAR10081.182Bos_taurus
ENSG00000160710ADAR5147.619WBGene00000080adr-29930.210Caenorhabditis_elegans
ENSG00000160710ADAR10095.596ENSCJAG00000009410ADAR9388.627Callithrix_jacchus
ENSG00000160710ADAR10086.681ENSCAFG00000017169ADAR10080.000Canis_familiaris
ENSG00000160710ADAR10089.474ENSCAFG00020008204ADAR10079.772Canis_lupus_dingo
ENSG00000160710ADAR10090.021ENSCHIG00000017156ADAR10080.685Capra_hircus
ENSG00000160710ADAR10094.092ENSTSYG00000013129ADAR10094.092Carlito_syrichta
ENSG00000160710ADAR10089.259ENSCAPG00000016091ADAR9979.290Cavia_aperea
ENSG00000160710ADAR10089.474ENSCPOG00000005463ADAR9979.119Cavia_porcellus
ENSG00000160710ADAR10096.133ENSCCAG00000028498ADAR10088.706Cebus_capucinus
ENSG00000160710ADAR10098.857ENSCATG00000028528ADAR10096.417Cercocebus_atys
ENSG00000160710ADAR10089.581ENSCLAG00000005402ADAR9989.581Chinchilla_lanigera
ENSG00000160710ADAR10098.571ENSCSAG00000001964ADAR10098.496Chlorocebus_sabaeus
ENSG00000160710ADAR9959.581ENSCPBG00000024639ADAR9961.547Chrysemys_picta_bellii
ENSG00000160710ADAR10098.389ENSCANG00000040049ADAR10096.493Colobus_angolensis_palliatus
ENSG00000160710ADAR10086.681ENSCGRG00001013419Adar9877.337Cricetulus_griseus_chok1gshd
ENSG00000160710ADAR10086.681ENSCGRG00000010821Adar9877.337Cricetulus_griseus_crigri
ENSG00000160710ADAR7573.984ENSCSEG00000002318adar7946.361Cynoglossus_semilaevis
ENSG00000160710ADAR7575.610ENSCVAG00000022718adar9242.781Cyprinodon_variegatus
ENSG00000160710ADAR9950.469ENSDARG00000012389adar8047.190Danio_rerio
ENSG00000160710ADAR10086.359ENSDNOG00000008913ADAR10080.000Dasypus_novemcinctus
ENSG00000160710ADAR10087.540ENSDORG00000007813Adar9987.540Dipodomys_ordii
ENSG00000160710ADAR10080.857ENSETEG00000015007ADAR9372.672Echinops_telfairi
ENSG00000160710ADAR7562.602ENSEBUG00000005741-7250.086Eptatretus_burgeri
ENSG00000160710ADAR7446.721ENSEBUG00000010302-6345.641Eptatretus_burgeri
ENSG00000160710ADAR10090.129ENSEASG00005000290ADAR10083.680Equus_asinus_asinus
ENSG00000160710ADAR10093.133ENSECAG00000000974ADAR10093.133Equus_caballus
ENSG00000160710ADAR8292.694ENSEEUG00000014864ADAR7892.694Erinaceus_europaeus
ENSG00000160710ADAR9950.375ENSELUG00000012523adar9551.602Esox_lucius
ENSG00000160710ADAR10087.111ENSFCAG00000001341ADAR10078.303Felis_catus
ENSG00000160710ADAR9957.729ENSFALG00000001232ADAR9953.635Ficedula_albicollis
ENSG00000160710ADAR10088.507ENSFDAG00000016081ADAR9988.507Fukomys_damarensis
ENSG00000160710ADAR7574.797ENSFHEG00000021099adar9244.290Fundulus_heteroclitus
ENSG00000160710ADAR10047.222ENSGMOG00000019052adar9942.925Gadus_morhua
ENSG00000160710ADAR9956.979ENSGALG00000021475ADAR19453.970Gallus_gallus
ENSG00000160710ADAR7576.423ENSGAFG00000014820adar9244.462Gambusia_affinis
ENSG00000160710ADAR10048.611ENSGACG00000011951adar9644.383Gasterosteus_aculeatus
ENSG00000160710ADAR9959.750ENSGAGG00000009803ADAR9654.342Gopherus_agassizii
ENSG00000160710ADAR10099.714ENSGGOG00000007156ADAR10099.103Gorilla_gorilla
ENSG00000160710ADAR7575.610ENSHBUG00000000091adar9244.323Haplochromis_burtoni
ENSG00000160710ADAR10087.111ENSHGLG00000017910ADAR9987.111Heterocephalus_glaber_female
ENSG00000160710ADAR10087.111ENSHGLG00100010770ADAR9987.111Heterocephalus_glaber_male
ENSG00000160710ADAR9948.980ENSHCOG00000007480adar9044.453Hippocampus_comes
ENSG00000160710ADAR9949.239ENSIPUG00000003263adar8145.812Ictalurus_punctatus
ENSG00000160710ADAR10087.648ENSSTOG00000014151ADAR9977.124Ictidomys_tridecemlineatus
ENSG00000160710ADAR10086.574ENSJJAG00000022056Adar9977.246Jaculus_jaculus
ENSG00000160710ADAR7575.610ENSKMAG00000002086adar9244.407Kryptolebias_marmoratus
ENSG00000160710ADAR10047.222ENSLBEG00000000352adar9142.632Labrus_bergylta
ENSG00000160710ADAR9954.689ENSLACG00000015329ADAR9850.179Latimeria_chalumnae
ENSG00000160710ADAR10091.944ENSLAFG00000017405ADAR10082.796Loxodonta_africana
ENSG00000160710ADAR10098.496ENSMFAG00000003217ADAR10096.656Macaca_fascicularis
ENSG00000160710ADAR10098.496ENSMMUG00000016093ADAR10096.656Macaca_mulatta
ENSG00000160710ADAR10098.281ENSMNEG00000031204ADAR9996.566Macaca_nemestrina
ENSG00000160710ADAR10098.496ENSMLEG00000029344ADAR10098.496Mandrillus_leucophaeus
ENSG00000160710ADAR9065.306ENSMAMG00000014398adar9156.329Mastacembelus_armatus
ENSG00000160710ADAR7575.610ENSMZEG00005015777adar7948.014Maylandia_zebra
ENSG00000160710ADAR9956.608ENSMGAG00000006645ADAR9062.824Meleagris_gallopavo
ENSG00000160710ADAR10087.003ENSMAUG00000015796Adar9987.003Mesocricetus_auratus
ENSG00000160710ADAR10092.266ENSMICG00000001431ADAR10084.515Microcebus_murinus
ENSG00000160710ADAR7592.683ENSMOCG00000018547Adar9989.107Microtus_ochrogaster
ENSG00000160710ADAR9951.441ENSMMOG00000003884adar9652.626Mola_mola
ENSG00000160710ADAR9962.222ENSMODG00000017160ADAR9955.920Monodelphis_domestica
ENSG00000160710ADAR7574.797ENSMALG00000020680adar9243.932Monopterus_albus
ENSG00000160710ADAR10085.822MGP_CAROLIEiJ_G0025215Adar9989.410Mus_caroli
ENSG00000160710ADAR10085.822ENSMUSG00000027951Adar9989.410Mus_musculus
ENSG00000160710ADAR10085.285MGP_PahariEiJ_G0026659Adar9988.654Mus_pahari
ENSG00000160710ADAR10085.822MGP_SPRETEiJ_G0026158Adar9989.410Mus_spretus
ENSG00000160710ADAR10083.459ENSMPUG00000007140ADAR9676.540Mustela_putorius_furo
ENSG00000160710ADAR10088.166ENSMLUG00000017678ADAR9979.593Myotis_lucifugus
ENSG00000160710ADAR10087.433ENSNGAG00000016696Adar9978.099Nannospalax_galili
ENSG00000160710ADAR9951.911ENSNBRG00000004510adar9653.005Neolamprologus_brichardi
ENSG00000160710ADAR10099.033ENSNLEG00000011458ADAR10093.883Nomascus_leucogenys
ENSG00000160710ADAR7573.984ENSMEUG00000012041-6861.258Notamacropus_eugenii
ENSG00000160710ADAR10077.981ENSOPRG00000000313ADAR9669.394Ochotona_princeps
ENSG00000160710ADAR10088.722ENSODEG00000011111ADAR9978.069Octodon_degus
ENSG00000160710ADAR9951.141ENSONIG00000006335adar9245.012Oreochromis_niloticus
ENSG00000160710ADAR10090.977ENSOCUG00000008544ADAR9979.934Oryctolagus_cuniculus
ENSG00000160710ADAR7576.423ENSORLG00000009955adar9145.497Oryzias_latipes
ENSG00000160710ADAR7576.423ENSORLG00020009688adar9145.632Oryzias_latipes_hni
ENSG00000160710ADAR7576.423ENSORLG00015015656adar9145.497Oryzias_latipes_hsok
ENSG00000160710ADAR7576.423ENSOMEG00000008019adar9144.890Oryzias_melastigma
ENSG00000160710ADAR10089.151ENSOGAG00000005587ADAR10081.616Otolemur_garnettii
ENSG00000160710ADAR10090.129ENSOARG00000002952ADAR9980.587Ovis_aries
ENSG00000160710ADAR10086.788ENSPPRG00000001779ADAR10086.788Panthera_pardus
ENSG00000160710ADAR8296.825ENSPTIG00000019964-9566.968Panthera_tigris_altaica
ENSG00000160710ADAR10099.785ENSPTRG00000022833ADAR10099.511Pan_troglodytes
ENSG00000160710ADAR10098.857ENSPANG00000008380ADAR9996.007Papio_anubis
ENSG00000160710ADAR7574.797ENSPKIG00000014435adar8046.604Paramormyrops_kingsleyae
ENSG00000160710ADAR10051.429ENSPSIG00000007571ADAR9960.343Pelodiscus_sinensis
ENSG00000160710ADAR9950.515ENSPMGG00000003925adar9244.722Periophthalmus_magnuspinnatus
ENSG00000160710ADAR10087.003ENSPEMG00000000814Adar9989.291Peromyscus_maniculatus_bairdii
ENSG00000160710ADAR9960.906ENSPCIG00000021738ADAR9957.038Phascolarctos_cinereus
ENSG00000160710ADAR7576.423ENSPFOG00000014636adar9244.470Poecilia_formosa
ENSG00000160710ADAR7576.423ENSPLAG00000022326adar9244.556Poecilia_latipinna
ENSG00000160710ADAR7576.423ENSPMEG00000007882adar9244.496Poecilia_mexicana
ENSG00000160710ADAR7576.423ENSPREG00000017446adar9244.833Poecilia_reticulata
ENSG00000160710ADAR10098.926ENSPPYG00000000776ADAR10098.369Pongo_abelii
ENSG00000160710ADAR10079.699ENSPCAG00000005550ADAR9672.368Procavia_capensis
ENSG00000160710ADAR10093.126ENSPCOG00000017300ADAR10085.330Propithecus_coquereli
ENSG00000160710ADAR9995.652ENSPVAG00000001256ADAR9093.603Pteropus_vampyrus
ENSG00000160710ADAR7575.610ENSPNYG00000004823adar7947.160Pundamilia_nyererei
ENSG00000160710ADAR7577.236ENSPNAG00000027353adar8147.230Pygocentrus_nattereri
ENSG00000160710ADAR10086.251ENSRNOG00000020744Adar9975.879Rattus_norvegicus
ENSG00000160710ADAR10098.571ENSRBIG00000040613-10095.773Rhinopithecus_bieti
ENSG00000160710ADAR10098.711ENSRROG00000033822ADAR10096.819Rhinopithecus_roxellana
ENSG00000160710ADAR10095.811ENSSBOG00000018272ADAR10092.496Saimiri_boliviensis_boliviensis
ENSG00000160710ADAR9962.087ENSSHAG00000014641ADAR9956.627Sarcophilus_harrisii
ENSG00000160710ADAR9953.676ENSSFOG00015021716adar7654.982Scleropages_formosus
ENSG00000160710ADAR5439.773ENSSMAG00000000557-8531.959Scophthalmus_maximus
ENSG00000160710ADAR9951.173ENSSMAG00000016465adar9143.611Scophthalmus_maximus
ENSG00000160710ADAR7574.797ENSSDUG00000006183adar9144.012Seriola_dumerili
ENSG00000160710ADAR7574.797ENSSLDG00000014208adar9144.090Seriola_lalandi_dorsalis
ENSG00000160710ADAR9754.674ENSSPUG00000002795ADAR9956.696Sphenodon_punctatus
ENSG00000160710ADAR7574.797ENSSPAG00000022397adar9144.627Stegastes_partitus
ENSG00000160710ADAR10087.325ENSSSCG00000006543ADAR10081.522Sus_scrofa
ENSG00000160710ADAR9958.493ENSTGUG00000004105ADAR10054.414Taeniopygia_guttata
ENSG00000160710ADAR9950.103ENSTRUG00000008870adar9144.681Takifugu_rubripes
ENSG00000160710ADAR9952.160ENSTNIG00000018320adar9949.032Tetraodon_nigroviridis
ENSG00000160710ADAR10090.763ENSTBEG00000013312ADAR9682.719Tupaia_belangeri
ENSG00000160710ADAR7597.561ENSTTRG00000014001ADAR7593.776Tursiops_truncatus
ENSG00000160710ADAR10084.640ENSUAMG00000014332ADAR10078.583Ursus_americanus
ENSG00000160710ADAR10084.425ENSUMAG00000019958ADAR9976.735Ursus_maritimus
ENSG00000160710ADAR7597.561ENSVPAG00000004789-5497.021Vicugna_pacos
ENSG00000160710ADAR10089.378ENSVVUG00000001831ADAR10085.300Vulpes_vulpes
ENSG00000160710ADAR9951.949ENSXETG00000003848adar9349.177Xenopus_tropicalis
ENSG00000160710ADAR7577.236ENSXCOG00000009420adar9653.245Xiphophorus_couchianus
ENSG00000160710ADAR7576.423ENSXMAG00000010557adar9245.151Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003677DNA binding-IEAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003725double-stranded RNA binding21873635.IBAFunction
GO:0003726double-stranded RNA adenosine deaminase activity21873635.IBAFunction
GO:0003726double-stranded RNA adenosine deaminase activity9020165.IDAFunction
GO:0003726double-stranded RNA adenosine deaminase activity7565688.NASFunction
GO:0005515protein binding18362360.22810585.23853584.24136289.28355180.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus18362360.23622242.IDAComponent
GO:0005634nucleus7565688.TASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm23622242.IDAComponent
GO:0005737cytoplasm7565688.TASComponent
GO:0006382adenosine to inosine editing21873635.IBAProcess
GO:0006382adenosine to inosine editing15858013.19651874.21289159.IDAProcess
GO:0006382adenosine to inosine editing16475990.IMPProcess
GO:0006382adenosine to inosine editing-TASProcess
GO:0006396RNA processing21873635.IBAProcess
GO:0006397mRNA processing-IEAProcess
GO:0008251tRNA-specific adenosine deaminase activity21873635.IBAFunction
GO:0009615response to virus15858013.IMPProcess
GO:0016020membrane19946888.HDAComponent
GO:0016553base conversion or substitution editing9020165.IDAProcess
GO:0031054pre-miRNA processing23622242.IDAProcess
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA23622242.IDAProcess
GO:0035455response to interferon-alpha16475990.IDAProcess
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation19651874.IDAProcess
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation18362360.IMPProcess
GO:0044530supraspliceosomal complex18362360.IDAComponent
GO:0045070positive regulation of viral genome replication19651874.IDAProcess
GO:0045070positive regulation of viral genome replication18362360.IMPProcess
GO:0045087innate immune response16475990.TASProcess
GO:0046872metal ion binding-IEAFunction
GO:0051607defense response to virus-IEAProcess
GO:0060337type I interferon signaling pathway-TASProcess
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