EuRBPDB

Ensembl ID

ENSG00000160633 (Gene tree)

Gene ID

6294

Gene Symbol

SAFB

Alias

HET|SAFB1

Full Name

scaffold attachment factor B

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Plus strand

Length

45,444 bases

Position

chr19:5,623,035-5,668,478

Accession

10520

Summary

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]