EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29037838Expression and epigenetic regulation of cystatin B in lung cancer and colorectal cancer.Pathol Res Pract2017 DecMa Ydoi: 10.1016/j.prp.2017.06.007
24452274Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-β signaling pathway.Int J Oncol2014 AprWang Xdoi: 10.3892/ijo.2014.2261
28281969CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line.Oncol Res2016 Oct 27Zhang Jdoi: 10.3727/096504016X14685034103752.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2143774276Missense_Mutationrs765382240H75Y0.16
BRCAchr21437741373'UTRnovel0.27
BRCAchr21437741373'UTRnovel0.18
BRCAchr21437741813'UTRnovel0.13
CESCchr2143774273Missense_MutationNAE76K0.23
COADchr21437762885'UTRnovel0.5
COADchr2143774284Missense_MutationnovelS72C0.06
HNSCchr2143774706SilentnovelA40A0.21
HNSCchr2143774282Missense_MutationnovelL73V0.29
LGGchr2143774658Missense_MutationnovelK56N0.45
LIHCchr2143774272Missense_MutationNAE76G0.08
LUADchr2143774701Missense_MutationnovelS42L0.13
MESOchr2143774325Silentrs763095750H58H0.72
OVchr2143774682Silentrs202096395V48V0.08
PRADchr2143774327Missense_MutationNAH58Y0.15
SKCMchr21437741823'UTRnovel0.66
SKCMchr21437741833'UTRrs63840.67
STADchr2143774241SilentnovelQ86Q0.32
STADchr2143774294Missense_MutationNAV69M0.43
UCECchr21437763615'UTRnovel0.36
UCECchr21437740213'UTRrs5582553230.24
UCECchr2143774297Nonsense_Mutationrs74315442R68*0.41
UCECchr2143774706Silentrs368198839A40A0.37
UCECchr21437740513'UTRnovel0.33
UCECchr2143774739Missense_MutationnovelE29D0.16
UCECchr21437741843'UTRnovel0.48
UCECchr2143774719Missense_MutationnovelP36H0.06

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.21740.018342
OVDEL0.13470.022578
TGCTDEL0.69330.21504
THYMAMP00.24554

Survival Analysis
CancerP-value Q-value
THYM0.0079

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

ACC0.032

Kaplan-Meier Survival Analysis

SKCM0.0018

Kaplan-Meier Survival Analysis

COAD0.026

Kaplan-Meier Survival Analysis

PAAD0.015

Kaplan-Meier Survival Analysis

PCPG0.021

Kaplan-Meier Survival Analysis

LAML0.003

Kaplan-Meier Survival Analysis

UCEC0.019

Kaplan-Meier Survival Analysis

GBM0.04

Kaplan-Meier Survival Analysis

LIHC0.00013

Kaplan-Meier Survival Analysis

DLBC0.011

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000160213 (Gene tree)
Gene ID
1476
Gene Symbol
CSTB
Alias
CST6|PME|EPM1|STFB
Full Name
cystatin B
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
3,935 bases
Position
chr21:43,772,511-43,776,445
Accession
2482
RBP type
non-canonical RBP
Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000639959CSTB-2031855-ENSP0000049212354 (aa)-A0A1W2PQG6
ENST00000291568CSTB-2012164-ENSP0000029156898 (aa)-P04080
ENST00000480147CSTB-2023744--- (aa)--
ENST00000640406CSTB-2042354-ENSP0000049267283 (aa)-A0A1W2PS52
Gene Model
Click here to download ENSG00000160213's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160213's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000160213CSTB10078.571ENSMUSG00000005054Cstb10078.571Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002020protease binding6203523.IPIFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0004866endopeptidase inhibitor activity3053245.TASFunction
GO:0004869cysteine-type endopeptidase inhibitor activity21873635.IBAFunction
GO:0004869cysteine-type endopeptidase inhibitor activity3488317.6203523.IDAFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space23580065.HDAComponent
GO:0005615extracellular space3488317.IDAComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm11139332.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0008344adult locomotory behavior-IEAProcess
GO:0010466negative regulation of peptidase activity6203523.IDAProcess
GO:0010951negative regulation of endopeptidase activity-IEAProcess
GO:0034774secretory granule lumen-TASComponent
GO:0043312neutrophil degranulation-TASProcess
GO:0045861negative regulation of proteolysis3488317.IDAProcess
GO:0062023collagen-containing extracellular matrix25037231.28675934.HDAComponent
GO:0070062extracellular exosome19056867.19199708.23533145.HDAComponent
GO:1904724tertiary granule lumen-TASComponent
GO:1904813ficolin-1-rich granule lumen-TASComponent
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