EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29037838	Expression and epigenetic regulation of cystatin B in lung cancer and colorectal cancer.	Pathol Res Pract	2017 Dec	Ma Y	doi: 10.1016/j.prp.2017.06.007
24452274	Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-β signaling pathway.	Int J Oncol	2014 Apr	Wang X	doi: 10.3892/ijo.2014.2261
28281969	CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line.	Oncol Res	2016 Oct 27	Zhang J	doi: 10.3727/096504016X14685034103752.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr21	43774276	Missense_Mutation	rs765382240	H75Y	0.16
BRCA	chr21	43774137	3'UTR	novel		0.27
BRCA	chr21	43774137	3'UTR	novel		0.18
BRCA	chr21	43774181	3'UTR	novel		0.13
CESC	chr21	43774273	Missense_Mutation	NA	E76K	0.23
COAD	chr21	43776288	5'UTR	novel		0.5
COAD	chr21	43774284	Missense_Mutation	novel	S72C	0.06
HNSC	chr21	43774706	Silent	novel	A40A	0.21
HNSC	chr21	43774282	Missense_Mutation	novel	L73V	0.29
LGG	chr21	43774658	Missense_Mutation	novel	K56N	0.45
LIHC	chr21	43774272	Missense_Mutation	NA	E76G	0.08
LUAD	chr21	43774701	Missense_Mutation	novel	S42L	0.13
MESO	chr21	43774325	Silent	rs763095750	H58H	0.72
OV	chr21	43774682	Silent	rs202096395	V48V	0.08
PRAD	chr21	43774327	Missense_Mutation	NA	H58Y	0.15
SKCM	chr21	43774182	3'UTR	novel		0.66
SKCM	chr21	43774183	3'UTR	rs6384		0.67
STAD	chr21	43774241	Silent	novel	Q86Q	0.32
STAD	chr21	43774294	Missense_Mutation	NA	V69M	0.43
UCEC	chr21	43776361	5'UTR	novel		0.36
UCEC	chr21	43774021	3'UTR	rs558255323		0.24
UCEC	chr21	43774297	Nonsense_Mutation	rs74315442	R68*	0.41
UCEC	chr21	43774706	Silent	rs368198839	A40A	0.37
UCEC	chr21	43774051	3'UTR	novel		0.33
UCEC	chr21	43774739	Missense_Mutation	novel	E29D	0.16
UCEC	chr21	43774184	3'UTR	novel		0.48
UCEC	chr21	43774719	Missense_Mutation	novel	P36H	0.06

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.2174	0.018342
OV	DEL	0.1347	0.022578
TGCT	DEL	0.6933	0.21504
THYM	AMP	0	0.24554

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0079	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.032	Kaplan-Meier Survival Analysis
SKCM	0.0018	Kaplan-Meier Survival Analysis
COAD	0.026	Kaplan-Meier Survival Analysis
PAAD	0.015	Kaplan-Meier Survival Analysis
PCPG	0.021	Kaplan-Meier Survival Analysis
LAML	0.003	Kaplan-Meier Survival Analysis
UCEC	0.019	Kaplan-Meier Survival Analysis
GBM	0.04	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
DLBC	0.011	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160213 (Gene tree)
Gene ID: 1476
Gene Symbol: CSTB
Alias: CST6|PME|EPM1|STFB
Full Name: cystatin B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 3,935 bases
Position: chr21:43,772,511-43,776,445
Accession: 2482
RBP type: non-canonical RBP
Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000639959	CSTB-203	1855	-	ENSP00000492123	54 (aa)	-	A0A1W2PQG6
ENST00000291568	CSTB-201	2164	-	ENSP00000291568	98 (aa)	-	P04080
ENST00000480147	CSTB-202	3744	-	-	- (aa)	-	-
ENST00000640406	CSTB-204	2354	-	ENSP00000492672	83 (aa)	-	A0A1W2PS52

Gene Model

Click here to download ENSG00000160213's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160213's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160213	CSTB	100	78.571	ENSMUSG00000005054	Cstb	100	78.571	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002020	protease binding	6203523.	IPI	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004866	endopeptidase inhibitor activity	3053245.	TAS	Function
GO:0004869	cysteine-type endopeptidase inhibitor activity	21873635.	IBA	Function
GO:0004869	cysteine-type endopeptidase inhibitor activity	3488317.6203523.	IDA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	23580065.	HDA	Component
GO:0005615	extracellular space	3488317.	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	11139332.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0008344	adult locomotory behavior	-	IEA	Process
GO:0010466	negative regulation of peptidase activity	6203523.	IDA	Process
GO:0010951	negative regulation of endopeptidase activity	-	IEA	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045861	negative regulation of proteolysis	3488317.	IDA	Process
GO:0062023	collagen-containing extracellular matrix	25037231.28675934.	HDA	Component
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component
GO:1904724	tertiary granule lumen	-	TAS	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.