EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
15748890The actin cytoskeleton-associated protein zyxin acts as a tumor suppressor in Ewing tumor cells.Exp Cell Res2005 Apr 1Amsellem V-
23321499Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.Cancer Lett2013 May 1Youn Hdoi: 10.1016/j.canlet.2012.12.019
22778267Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.J Biol Chem2012 Sep 7Mise Ndoi: 10.1074/jbc.M112.357624
29967145Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.Proc Natl Acad Sci U S A2018 Jul 17Zhou Jdoi: 10.1073/pnas.1800621115

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr71433907513'UTRnovel0.29
ACCchr7143390641Missense_Mutationrs747069930V560M0.1
BLCAchr7143382402SilentNAP121P0.47
BLCAchr7143388540Missense_Mutationrs576382219R399H0.42
BLCAchr7143381609Missense_Mutationrs748403980S13L0.4
BRCAchr7143382273SilentnovelL78L0.6
BRCAchr7143383001SilentNAV234V0.19
BRCAchr7143388800Missense_MutationNAP450S0.57
BRCAchr7143382591Splice_SitenovelX137_splice0.03
BRCAchr7143382592Splice_SitenovelX137_splice0.03
BRCAchr7143388844Silentrs145663530H464H0.22
CESCchr7143382651Missense_MutationnovelD156V0.07
CESCchr7143388540Missense_Mutationrs576382219R399H0.33
CESCchr7143383101Missense_Mutationrs758266725P268A0.29
CESCchr7143382978Nonsense_MutationNAQ227*0.46
CHOLchr7143383114Missense_MutationnovelK272T0.36
CHOLchr7143382308Missense_MutationNAG90E0.15
COADchr7143389927Nonsense_Mutationrs750192633R522*0.08
COADchr7143389935SilentnovelV524V0.46
COADchr7143383036Missense_MutationNAS246Y0.33
COADchr7143382359Missense_MutationNAA107V0.23
COADchr7143389878Silentrs142687371S505S0.28
COADchr7143388560Missense_MutationNAH406Y0.19
ESCAchr7143383081Missense_MutationnovelA261G0.37
GBMchr7143388871Silentrs146983863C473C0.2
GBMchr7143383159Missense_MutationNAG287E0.33
GBMchr7143383206Missense_MutationNAS303P0.29
HNSCchr7143382355Missense_MutationnovelP106T0.11
HNSCchr7143388891Missense_MutationnovelT480I0.14
HNSCchr7143388892Silentrs142288548T480T0.13
HNSCchr7143382650Missense_MutationnovelD156N0.42
KIRCchr7143382668Missense_Mutationrs777343615D162N0.16
KIRPchr7143383199Silentrs140819301E300E0.1
LAMLchr7143389924Missense_MutationnovelV521M0.05
LGGchr7143382600In_Frame_DelnovelK140del0.2
LIHCchr7143383075Missense_MutationnovelS259Y0.56
LUADchr7143382618Missense_MutationnovelD145V0.09
LUADchr7143382684Missense_MutationNAR167L0.3
LUADchr7143388643Silentrs374951395C433C0.15
LUADchr7143382898Missense_Mutationrs150223874W200L0.14
LUADchr7143388559SilentnovelF405F0.13
LUADchr7143381719Missense_MutationNAP50S0.2
LUSCchr7143389888Missense_MutationnovelE509Q0.1
LUSCchr7143382369SilentNAE110E0.32
LUSCchr7143383197Missense_Mutationrs368759415E300K0.09
LUSCchr7143388651Missense_MutationnovelC436S0.3
LUSCchr7143388803Missense_MutationNAI451V0.16
LUSCchr7143382436Missense_MutationnovelP133S0.13
LUSCchr7143383195Missense_MutationnovelP299L0.27
OVchr7143382887SilentnovelP196P0.14
OVchr7143382831Missense_MutationnovelA178T0.12
OVchr7143382938Silentrs543840726P213P0.06
PAADchr7143382367Nonsense_MutationnovelE110*0.08
PAADchr7143382375SilentnovelE112E0.06
PRADchr7143388526SilentnovelA394A0.51
READchr7143389879Missense_Mutationrs569088357V506I0.32
READchr7143383111Missense_MutationnovelP271H0.33
READchr7143382837Missense_MutationnovelP180T0.28
READchr7143388871Silentrs146983863C473C0.16
SARCchr7143390553Intronnovel0.18
SKCMchr7143383196Silentrs766453615P299P0.46
SKCMchr7143382910Missense_Mutationrs768328401S204F0.54
SKCMchr7143383291Missense_MutationNAP331L0.36
SKCMchr7143388913SilentnovelA487A0.37
SKCMchr7143382871Missense_MutationNAA191V0.72
SKCMchr7143381684Missense_MutationnovelP38L0.32
SKCMchr7143381685Silentrs554528272P38P0.33
SKCMchr7143382318SilentNAF93F0.45
SKCMchr7143382343Missense_MutationNAE102K0.46
SKCMchr7143388313Missense_MutationNAP373L0.17
SKCMchr7143382428Missense_MutationnovelP130L0.15
SKCMchr7143382429SilentnovelP130P0.15
SKCMchr7143388901Silentrs574219835I483I0.48
SKCMchr7143383116Missense_MutationNAF273V0.05
SKCMchr7143389867Missense_MutationNAP502S0.2
SKCMchr7143389913Missense_Mutationrs773528813R517Q0.28
SKCMchr7143388315Nonsense_MutationnovelQ374*0.27
STADchr7143388540Missense_Mutationrs576382219R399H0.14
STADchr7143388633Missense_MutationNAA430E0.33
STADchr7143389934Missense_MutationNAV524A0.18
STADchr7143382882Missense_MutationNAA195T0.25
STADchr7143382934Missense_MutationNAV212A0.16
STADchr7143382844Missense_MutationNAS182N0.28
STADchr7143389975Missense_MutationNAE538K0.29
STADchr7143388526SilentnovelA394A0.53
UCECchr7143388339Missense_MutationNAE382K0.5
UCECchr7143382664Missense_MutationnovelK160N0.28
UCECchr7143381668Missense_MutationnovelK33E0.22
UCECchr7143388308SilentnovelE371E0.35
UCECchr7143389946Missense_MutationnovelK528T0.25
UCECchr7143383071Missense_MutationNAS258A0.17
UCECchr71433909863'UTRnovel0.29
UCECchr7143388936Missense_MutationnovelD495G0.33
UCECchr7143382617Missense_MutationNAD145N0.26
UCECchr7143388781Missense_Mutationrs777931036K443N0.1
UCECchr7143390651Missense_Mutationrs149835123R563Q0.27
UCECchr7143388861Missense_Mutationrs751775395C470Y0.22
UCECchr7143389936Missense_MutationNAA525T0.44
UCECchr7143382402SilentNAP121P0.5
UCECchr71433910883'UTRnovel0.38
UCECchr7143389857Splice_RegionnovelK498K0.27
UCECchr71433910523'UTRnovel0.21
UCECchr7143388306Missense_MutationnovelE371K0.45
UCECchr7143388592Silentrs541672435A416A0.37
UCECchr71433908223'UTRnovel0.23
UCECchr7143388245SilentnovelP350P0.55
UCECchr7143383197Missense_Mutationrs368759415E300K0.36
UCECchr7143388872Missense_Mutationrs781295880A474T0.35
UCECchr7143390584Missense_Mutationrs756852682G541R0.07
UCECchr7143382247Splice_SitenovelX70_splice0.17
UCECchr7143382856Missense_MutationnovelS186N0.37
UCECchr7143382286Missense_MutationnovelD83N0.52
UCECchr7143388339Nonsense_MutationNAE382*0.3
UCECchr7143383197Missense_Mutationrs368759415E300K0.19
UCECchr7143382354SilentNAP105P0.24
UCECchr7143382986Silentrs747897982Q229Q0.27
UCECchr7143383315Frame_Shift_DelnovelN340Tfs*120.47
UCECchr7143390584Missense_Mutationrs756852682G541R0.31
UCECchr7143383077Missense_MutationNAP260T0.24
UCECchr71433910163'UTRnovel0.5
UCSchr7143389923SilentnovelT520T0.48

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.06670.12261
CESCDEL0.17970.0016147
DLBCDEL0.08330.03486
KIRCAMP0.2860.075418
LAMLDEL0.12573.4101e-05
LGGAMP0.31191.5525e-07
LIHCDEL0.08110.24831
PAADDEL0.05980.049388
TGCTDEL0.06670.11738
THCADEL00.27619
UCECDEL0.09280.0001859
UCSDEL0.30360.10142

Survival Analysis
CancerP-value Q-value
KIRC0.00052

Kaplan-Meier Survival Analysis

SARC0.0051

Kaplan-Meier Survival Analysis

MESO0.0021

Kaplan-Meier Survival Analysis

SKCM0.015

Kaplan-Meier Survival Analysis

LUSC0.0062

Kaplan-Meier Survival Analysis

BRCA0.005

Kaplan-Meier Survival Analysis

ESCA0.015

Kaplan-Meier Survival Analysis

COAD0.048

Kaplan-Meier Survival Analysis

LAML0.0043

Kaplan-Meier Survival Analysis

LIHC0.0065

Kaplan-Meier Survival Analysis

CHOL0.047

Kaplan-Meier Survival Analysis

LUAD0.045

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000159840 (Gene tree)
Gene ID
7791
Gene Symbol
ZYX
Alias
N
Full Name
zyxin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
12,783 bases
Position
chr7:143,378,329-143,391,111
Accession
13200
RBP type
non-canonical RBP
Summary
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
11950970The rice mutant esp2 greatly accumulates the glutelin precursor and deletes the protein disulfide isomerase.Plant Physiol2002 AprTakemoto Y-
22395610Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.Nat Commun2012 Mar 6Fraley SIdoi: 10.1038/ncomms1711.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000497119ZYX-210560--- (aa)--
ENST00000436448ZYX-204632-ENSP00000411230176 (aa)-H7C3D3
ENST00000322764ZYX-2012493XM_017012587ENSP00000324422572 (aa)XP_016868076Q15942
ENST00000446634ZYX-205926-ENSP00000403714171 (aa)-C9JJK5
ENST00000457235ZYX-207703-ENSP00000400537164 (aa)-C9IZ41
ENST00000477373ZYX-209504--- (aa)--
ENST00000449630ZYX-206533-ENSP00000413467177 (aa)-H7C3R3
ENST00000468083ZYX-2081146--- (aa)--
ENST00000354434ZYX-2022050XM_011516569ENSP00000346417540 (aa)-H0Y2Y8
ENST00000392910ZYX-2032123-ENSP00000376642415 (aa)-Q15942
Gene Model
Click here to download ENSG00000159840's gene model file
Pathways
Pathway IDPathway NameSource
hsa04510Focal adhesionKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000159840rs117728957143384849CWhite blood cell count (basophil)27863252[0.015-0.031] unit increase0.02311239EFO_0005090
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159840's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000159840ZYX9146.835ENSG00000087077TRIP69140.609Homo_sapiens
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001725stress fiber18297730.24036928.IDAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding10831611.22665060.23840749.25416956.26871637.IPIFunction
GO:0005634nucleus24036928.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005913cell-cell adherens junction8940160.IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion12417594.18297730.IDAComponent
GO:0007160cell-matrix adhesion24036928.ICProcess
GO:0007179transforming growth factor beta receptor signaling pathway24036928.IMPProcess
GO:0007229integrin-mediated signaling pathway24036928.IMPProcess
GO:0007267cell-cell signaling8940160.TASProcess
GO:0016032viral process-IEAProcess
GO:0043149stress fiber assembly24036928.IMPProcess
GO:0045335phagocytic vesicle-IEAComponent
GO:0046872metal ion binding-IEAFunction
GO:0050727regulation of inflammatory response-IEAProcess
GO:0071346cellular response to interferon-gamma-IEAProcess
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