EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28498475Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16E7-induced cervical cancer and suppresses tumor growth.Int J Oncol2017 JunLiu Ydoi: 10.3892/ijo.2017.3979
22825642Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.Arch Orthop Trauma Surg2012 NovHoshi Mdoi: 10.1007/s00402-012-1588-2
24363061Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma.Tumour Biol2014 AprChen Jdoi: 10.1007/s13277-013-1496-2
24033605Tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.Cancer Sci2013 DecYoshino Hdoi: 10.1111/cas.12280
23071593Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.PLoS One2012Kwee SAdoi: 10.1371/journal.pone.0046591
21242296Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.J Exp Med2011 Feb 14Wolf Adoi: 10.1084/jem.20101470
19049977Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.J Biol Chem2009 Feb 6Arzoine Ldoi: 10.1074/jbc.M803614200
25060325Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.Cancer Sci2014 SepHamabe Adoi: 10.1111/cas.12487
28174335MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2.Biosci Rep2017 Jun 8Sun Xdoi: 10.1042/BSR20160404
29763606MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.Biochem Biophys Res Commun2018 Jul 2Liu Ydoi: 10.1016/j.bbrc.2018.05.069
26802651Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.Oncol Res2016Xi Fdoi: 10.3727/096504015X14459480491740.
22593586MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.J Biol Chem2012 Jun 29Fang Rdoi: 10.1074/jbc.M112.373084
18535403Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.Cancer Biol Ther2008 JulPeng Q-
11688991Identification of genes differentially induced by hypoxia in pancreatic cancer cells.Biochem Biophys Res Commun2001 Nov 9Yoon DY-
18772588Downregulation of the hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.Chemotherapy2008Peng QPdoi: 10.1159/000153655
24051093INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.Biochem Biophys Res Commun2013 Oct 11Min JWdoi: 10.1016/j.bbrc.2013.09.041
20958264Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.Biochem J2011 Jan 1Moon JSdoi: 10.1042/BJ20101104.
22691140MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells.BMC Cancer2012 Jun 12Gregersen LHdoi: 10.1186/1471-2407-12-232.
24890811Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway.Cancer Sci2014 AugLi Zdoi: 10.1111/cas.12461.
14672622Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.J Hepatol2004 JanYasuda S-
19003546Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer.Med Oncol2009He HCdoi: 10.1007/s12032-008-9120-9
15967114[18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung.Neoplasia2005 AprMamede M-
21411499Glucose metabolism gene variants modulate the risk of pancreatic cancer.Cancer Prev Res (Phila)2011 MayDong Xdoi: 10.1158/1940-6207.CAPR-10-0247
19723875Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.Mol Cancer Res2009 SepPalmieri Ddoi: 10.1158/1541-7786.MCR-09-0234
26607110miR-4458 suppresses glycolysis and lactate production by directly targeting hexokinase2 in colon cancer cells.Biochem Biophys Res Commun2016 Jan 1Qin Ydoi: 10.1016/j.bbrc.2015.11.066
22398711Correlation between FDG uptake by PET/CT and the expressions of glucose transporter type 1 and hexokinase II in cervical cancer.Int J Gynecol Cancer2012 MayTong SYdoi: 10.1097/IGC.0b013e31824864e6.
16551620Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.J Biol Chem2006 May 19Machida K-
20846459A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.J Exp Clin Cancer Res2010 Sep 17Guo-Qing Pdoi: 10.1186/1756-9966-29-129.
27315591Inhibition of microRNA-155 sensitizes lung cancer cells to irradiation via suppression of HK2-modulated glucose metabolism.Mol Med Rep2016 AugLv Xdoi: 10.3892/mmr.2016.5394
28184935Involvement of EZH2 in aerobic glycolysis of prostate cancer through miR-181b/HK2 axis.Oncol Rep2017 MarTao Tdoi: 10.3892/or.2017.5430
28347233Glycolysis-related protein expression in thyroid cancer.Tumour Biol2017 MarNahm JHdoi: 10.1177/1010428317695922.
28488541MicroRNA-124 suppresses proliferation and glycolysis in non-small cell lung cancer cells by targeting AKT-GLUT1/HKII.Tumour Biol2017 MayZhao Xdoi: 10.1177/1010428317706215.
28025745MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.Dig Dis Sci2017 MarZhu Wdoi: 10.1007/s10620-016-4418-5
28641488UCA1 involved in the metformin-regulated bladder cancer cell proliferation and glycolysis.Tumour Biol2017 JunLi Tdoi: 10.1177/1010428317710823.
28098871Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.Oncol Rep2017 MarZhang Hdoi: 10.3892/or.2017.5367
29114069BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.J Cell Biol2017 Dec 4An MXdoi: 10.1083/jcb.201701064
29247711Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy.Int J Biochem Cell Biol2018 FebZhang XYdoi: 10.1016/j.biocel.2017.12.010
30015920Long noncoding RNA urothelial cancer associated1 regulates radioresistance via the hexokinase2/glycolytic pathway in cervical cancer.Int J Mol Med2018 OctFan Ldoi: 10.3892/ijmm.2018.3778
28596599The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma.Sci Rep2017 Jun 8Jin Fdoi: 10.1038/s41598-017-03407-3.
29985480PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.Oncogene2018 NovYang Tdoi: 10.1038/s41388-018-0386-x
29384225Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells.J Cell Biochem2018 JunGao Xdoi: 10.1002/jcb.26742
28980855Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2).Autophagy2018Jiao Ldoi: 10.1080/15548627.2017.1381804

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr274887977Missense_MutationnovelG765V0.15
ACCchr274877230Missense_MutationnovelA314T0.5
ACCchr274878813Missense_MutationnovelC386Y0.34
BLCAchr274877317Missense_MutationnovelE343K0.22
BLCAchr274882208Missense_MutationnovelS603Y0.19
BLCAchr274834606Missense_Mutationrs768264746Y9F0.71
BLCAchr274834591Missense_MutationNAS4W0.28
BLCAchr274888004Missense_MutationnovelE774V0.16
BLCAchr274889297Missense_MutationNAE810Q0.16
BLCAchr274888048Nonsense_MutationnovelQ789*0.2
BLCAchr274882174Nonsense_MutationnovelK592*0.15
BLCAchr274889431SilentnovelL854L0.65
BLCAchr274887909Missense_MutationnovelE742D0.29
BRCAchr274878816Missense_MutationnovelA387V0.1
BRCAchr274880328SilentNAL443L0.32
BRCAchr2748345395'UTRrs7606982700.18
BRCAchr274890802Missense_MutationNAA872V0.29
BRCAchr274878685Splice_Regionnovel0.33
BRCAchr274880488SilentNAR497R0.32
BRCAchr274874323Missense_MutationNAG250A0.42
BRCAchr274874424Missense_MutationnovelG284C0.09
CESCchr274867641Missense_Mutationrs749170805G78R0.34
CESCchr274889270Nonsense_MutationNAR801*0.33
CESCchr274880494SilentnovelL499L0.25
CESCchr274880328SilentNAL443L0.4
CESCchr274880522Frame_Shift_InsnovelV509Gfs*690.08
CESCchr274878843Missense_MutationnovelR396H0.42
CESCchr274880528Missense_MutationnovelK510R0.11
CESCchr274881749Missense_MutationnovelN537D0.29
CESCchr274872339Missense_MutationnovelD139N0.08
CESCchr2748920853'UTRnovel0.24
CESCchr2748345395'UTRrs7606982700.32
CESCchr274881754Missense_MutationNAF538L0.25
CESCchr274874280Missense_MutationNAA236S0.3
CHOLchr274873292Missense_MutationnovelW171L0.53
CHOLchr2748918053'UTRrs5731401470.17
COADchr274889450Missense_MutationNAD861Y0.38
COADchr274880383Missense_MutationnovelR462W0.17
COADchr274889312Missense_MutationnovelD815N0.09
COADchr274886532Missense_MutationnovelV693A0.35
COADchr274854317Missense_Mutationrs567201785R30C0.37
COADchr274878871Silentrs779743587R405R0.36
COADchr274874309Silentrs373457354I245I0.39
COADchr274877228Missense_MutationNAM313T0.32
COADchr274881771Missense_Mutationrs62642507R544H0.18
COADchr274886526Missense_Mutationrs746400081R691H0.2
COADchr274881743Nonsense_MutationNAG535*0.31
COADchr274881739SilentnovelL533L0.16
COADchr274873326SilentnovelG182G0.32
COADchr274880293Missense_Mutationrs148796379R432W0.14
COADchr274881803In_Frame_InsnovelM555delinsTV0.09
COADchr274881805Missense_MutationnovelM555I0.05
COADchr274881820Silentrs369669565Y560Y0.26
COADchr274890891Missense_MutationNAA902T0.27
ESCAchr2748918063'UTRnovel0.36
ESCAchr274867681Missense_Mutationrs746133519R91H0.14
ESCAchr2748345435'UTRnovel0.52
ESCAchr274888001Missense_MutationnovelS773L0.43
GBMchr274854304Nonsense_MutationnovelY25*0.08
GBMchr274880467Missense_MutationnovelR490G0.21
GBMchr274854317Missense_Mutationrs567201785R30C0.08
GBMchr274887982Missense_MutationnovelL767I0.31
GBMchr274889312Missense_MutationnovelD815N0.61
GBMchr274877243Missense_MutationnovelL318R0.31
GBMchr274886558Missense_MutationNAR702W0.3
GBMchr274873299Missense_MutationnovelK173N0.12
GBMchr274889271Missense_Mutationrs28363057R801Q0.55
GBMchr274888056Splice_SitenovelX791_splice0.07
HNSCchr2748345325'UTRnovel0.09
HNSCchr274834583Translation_Start_SitenovelM1?0.11
HNSCchr274890798Frame_Shift_DelnovelF871Lfs*90.54
HNSCchr274873289Nonsense_MutationnovelS170*0.14
HNSCchr274889352Missense_Mutationrs148653106R828Q0.37
HNSCchr274888030Missense_MutationnovelE783Q0.22
HNSCchr274880312Missense_MutationnovelC438F0.25
LAMLchr274880486Missense_MutationnovelE496V0.46
LGGchr274886493Missense_Mutationrs138539339T680M0.3
LGGchr274880562Silentrs144796715D521D0.26
LGGchr274880384Missense_MutationnovelR462Q0.41
LGGchr274886559Missense_Mutationrs767300432R702Q0.35
LIHCchr274882236Silentrs200225889D612D0.1
LIHCchr274886508Missense_MutationNAC685F0.41
LIHCchr274880281Missense_MutationnovelH428D0.46
LIHCchr274877241SilentNAE317E0.23
LIHCchr274886365SilentnovelD669D0.36
LIHCchr274886654Missense_MutationNAL734F0.52
LIHCchr274854327Missense_MutationnovelD33G0.1
LUADchr274890857SilentNAF890F0.14
LUADchr274886505Missense_MutationNAA684V0.2
LUADchr274877287Missense_Mutationrs750616279R333C0.08
LUADchr274889356SilentNAR829R0.31
LUADchr274873317SilentnovelG179G0.08
LUADchr274882158SilentNAL586L0.17
LUADchr274886624Missense_MutationNAE724K0.13
LUADchr274886663Missense_MutationnovelG737S0.07
LUADchr274872337Missense_MutationNAM138T0.26
LUADchr274890922Missense_MutationNAR912L0.56
LUADchr274887934Missense_MutationNAG751C0.54
LUADchr274880524Missense_Mutationrs763634644V509I0.26
LUADchr274886347Missense_MutationnovelM663I0.27
LUSCchr274885530Missense_MutationnovelS626T0.44
LUSCchr274890916Missense_Mutationrs770307123R910H0.33
LUSCchr274889368SilentnovelL833L0.15
LUSCchr274874302Missense_MutationNAR243L0.23
LUSCchr274890853Missense_Mutationrs764837491S889C0.15
LUSCchr274889253Frame_Shift_DelnovelL795Rfs*100.42
LUSCchr274886541Missense_MutationNAV696E0.13
LUSCchr274878798Missense_MutationnovelR381L0.25
LUSCchr274880521Missense_MutationnovelP508S0.29
LUSCchr274881752Missense_MutationnovelF538I0.07
LUSCchr274887923Missense_MutationnovelG747E0.4
LUSCchr274880294Missense_Mutationrs773701506R432Q0.33
LUSCchr274854393Missense_MutationnovelT55I0.36
LUSCchr274887907Missense_MutationNAE742Q0.09
OVchr274878695Missense_MutationnovelD347N0.36
OVchr2748910003'UTRnovel0.14
OVchr274854449Missense_MutationNAG74W0.43
OVchr274881725SilentnovelL529L0.05
OVchr274881758Missense_MutationnovelV540L0.18
OVchr274877216Missense_MutationnovelI309T0.06
OVchr2748917593'UTRnovel0.33
OVchr274890820Missense_MutationnovelT878I0.03
OVchr274890822Missense_MutationnovelV879M0.02
OVchr274889414Missense_Mutationrs750043718R849C0.44
PAADchr274867635Splice_SitenovelX76_splice0.17
PAADchr274878714Missense_MutationnovelR353H0.35
PRADchr274854305Missense_MutationNAL26I0.37
PRADchr274887973Missense_Mutationrs767373447R764C0.34
READchr274886524Missense_MutationnovelM690I0.28
READchr274880503Missense_Mutationrs199889864E502K0.17
SARCchr274880451SilentnovelL484L0.4
SARCchr274888048Missense_Mutationrs780880800Q789E0.26
SARCchr274867680Missense_Mutationrs371320494R91C0.16
SKCMchr274877266Missense_MutationnovelP326S0.23
SKCMchr274877267Missense_MutationnovelP326L0.24
SKCMchr274881827Missense_MutationNAP563S0.21
SKCMchr274885545Missense_Mutationrs780187573E631K0.39
SKCMchr274885547SilentnovelE631E0.38
SKCMchr274872394Missense_MutationNAP157L0.36
SKCMchr274874380Missense_Mutationrs772185128S269L0.56
SKCMchr274890857SilentNAF890F0.24
SKCMchr274880329Missense_Mutationrs573942688R444C0.34
SKCMchr274888026SilentNAI781I0.31
SKCMchr274867752Missense_MutationNAP115S0.31
SKCMchr274880522Missense_MutationnovelP508L0.33
SKCMchr274880523Silentrs142174869P508P0.34
SKCMchr274887956Missense_MutationNAL758P0.19
SKCMchr274887968Missense_MutationNAT762I0.25
SKCMchr274877275Missense_MutationNAL329F0.11
SKCMchr274882128SilentNAD576D0.14
SKCMchr274877246Missense_MutationnovelL319H0.22
SKCMchr274873365SilentNAR195R0.12
SKCMchr274873908Missense_MutationNAY219F0.17
SKCMchr274889406Missense_Mutationrs767145519R846Q0.51
SKCMchr274887945SilentnovelV754V0.05
SKCMchr274881832SilentNAQ564Q0.38
SKCMchr274882212SilentNAF604F0.06
SKCMchr274873298Missense_MutationnovelK173M0.25
SKCMchr274873299SilentnovelK173K0.25
SKCMchr274874295Missense_MutationnovelE241K0.24
STADchr274873337Missense_MutationNAV186A0.11
STADchr274885532SilentNAS626S0.15
STADchr274867768Missense_MutationNAR120Q0.31
STADchr274867659Missense_MutationnovelD84Y0.45
STADchr274873938Missense_MutationNAI229T0.19
STADchr274886526Missense_Mutationrs746400081R691H0.3
STADchr274834596SilentNAL6L0.28
STADchr274874280Missense_MutationNAA236T0.22
STADchr274880290Frame_Shift_DelnovelV431Cfs*260.21
STADchr274881837Missense_MutationnovelV566A0.18
STADchr274889342Missense_MutationNAV825M0.16
STADchr274889456Missense_MutationNAT863A0.27
STADchr274889316Missense_MutationNAS816N0.23
STADchr274872316Missense_MutationnovelA131V0.53
STADchr274874271Missense_MutationnovelG233C0.41
UCECchr274874433Missense_MutationNAN287D0.32
UCECchr274890879Missense_MutationnovelG898R0.59
UCECchr274887929Missense_MutationnovelY749C0.31
UCECchr274889312Missense_MutationnovelD815N0.25
UCECchr274854318Missense_MutationnovelR30L0.07
UCECchr274890884Frame_Shift_Delrs771887254A901Rfs*740.37
UCECchr274867681Missense_Mutationrs746133519R91H0.06
UCECchr274889329Missense_MutationnovelK820N0.43
UCECchr274880274Missense_MutationnovelK425N0.42
UCECchr274873275Splice_SitenovelX166_splice0.35
UCECchr274877313Silentrs749637190D341D0.52
UCECchr274880383Missense_MutationnovelR462W0.36
UCECchr274886336Missense_Mutationrs763967521G660R0.52
UCECchr274880541SilentnovelT514T0.14
UCECchr274882236Silentrs200225889D612D0.29
UCECchr2748909543'UTRnovel0.27
UCECchr274889446SilentnovelG859G0.42
UCECchr274890890Silentrs779051510A901A0.29
UCECchr274885555Missense_MutationNAV634A0.35
UCECchr274887907Missense_MutationnovelE742K0.32
UCECchr274890805Missense_MutationnovelK873T0.23
UCECchr274867721Missense_MutationnovelK104N0.09
UCECchr274881827Missense_MutationNAP563S0.33
UCECchr274886490Missense_Mutationrs765371876G679D0.27
UCECchr2748909863'UTRnovel0.25
UCECchr2748920423'UTRnovel0.22
UCECchr274867775SilentnovelS122S0.2
UCECchr2748921173'UTRnovel0.53
UCECchr2748916863'UTRnovel1
UCECchr274873856Missense_MutationNAD202N0.51
UCECchr274882179Silentrs532190486G593G0.49
UCECchr274886336Missense_Mutationrs763967521G660R0.41
UCECchr274887974Missense_Mutationrs527493699R764H0.48
UCECchr2748918823'UTRnovel0.39
UCECchr274867727Missense_MutationnovelE106D0.49
UCECchr274873856Missense_MutationNAD202N0.53
UCECchr274877288Missense_Mutationrs756426288R333H0.11
UCECchr274878892Silentrs749015495V412V0.29
UCECchr274888014Missense_MutationnovelK777N0.08
UCECchr274834587Missense_MutationnovelA3P0.04
UCECchr274890916Missense_Mutationrs770307123R910H0.38
UCECchr274872417Missense_MutationnovelE165K0.33
UCECchr274881829Silentrs769749367P563P0.32
UCECchr274886619Missense_Mutationrs773823434R722H0.19
UCECchr274874285SilentnovelC237C0.15
UCECchr274854354Missense_Mutationrs375609405R42Q0.39
UCECchr274890850Missense_Mutationrs759264948V888A0.31
UCECchr274889311Silentrs761447119D814D0.14
UCECchr274890815SilentNAH876H0.21
UCECchr274880321Missense_MutationnovelR441H0.39
UCECchr274867768Missense_MutationNAR120Q0.36
UCECchr274886525Missense_Mutationrs147295617R691C0.16
UCECchr274889271Missense_Mutationrs28363057R801Q0.29
UCECchr274834627Missense_MutationNAH16R0.31
UCECchr274890796Splice_SiteNAX870_splice0.27
UCECchr274874355Missense_MutationnovelW261R0.27
UCSchr274886622Missense_MutationnovelT723I0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.02430.08832
PAADDEL0.04890.2014
READDEL0.07270.19022

Survival Analysis
CancerP-value Q-value
SARC0.0062

Kaplan-Meier Survival Analysis

ACC0.0011

Kaplan-Meier Survival Analysis

ESCA0.032

Kaplan-Meier Survival Analysis

KIRP0.032

Kaplan-Meier Survival Analysis

PAAD0.01

Kaplan-Meier Survival Analysis

CESC0.00091

Kaplan-Meier Survival Analysis

LAML0.00079

Kaplan-Meier Survival Analysis

KICH0.029

Kaplan-Meier Survival Analysis

LIHC0.0046

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.0024

Kaplan-Meier Survival Analysis

UVM0.043

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000159399 (Gene tree)
Gene ID
3099
Gene Symbol
HK2
Alias
N
Full Name
hexokinase 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
60,705 bases
Position
chr2:74,832,655-74,893,359
Accession
4923
RBP type
non-canonical RBP
Summary
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26247723Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein.Cell Death Dis2015 Aug 6Courteau Ldoi: 10.1038/cddis.2015.209.
29114069BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.J Cell Biol2017 Dec 4An MXdoi: 10.1083/jcb.201701064
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000409174HK2-2025278-ENSP00000387140889 (aa)-E9PB90
ENST00000290573HK2-2015772XM_005264280ENSP00000290573917 (aa)XP_005264337P52789
ENST00000472302HK2-203395--- (aa)--
Gene Model
Click here to download ENSG00000159399's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa00051Fructose and mannose metabolismKEGG
hsa00052Galactose metabolismKEGG
hsa00500Starch and sucrose metabolismKEGG
hsa00520Amino sugar and nucleotide sugar metabolismKEGG
hsa00524Neomycin, kanamycin and gentamicin biosynthesisKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
hsa04066HIF-1 signaling pathwayKEGG
hsa04910Insulin signaling pathwayKEGG
hsa04930Type II diabetes mellitusKEGG
hsa04973Carbohydrate digestion and absorptionKEGG
hsa05230Central carbon metabolism in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000159399Echocardiography8.66735298510335E-617903301
ENSG00000159399Echocardiography7.56992495265507E-617903301
ENSG00000159399Child Development Disorders, Pervasive6.2042500E-005-
ENSG00000159399Child Development Disorders, Pervasive4.1128000E-005-
ENSG00000159399Femur Neck3E-622087292
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000159399rs681900274847840?Femoral neck bone geometry22087292EFO_0004511
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159399's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000159399HK29973.982ENSG00000156515HK19973.982Homo_sapiens
ENSG00000159399HK210094.713ENSMUSG00000000628Hk210097.674Mus_musculus
ENSG00000159399HK29635.841YFR053C9135.683Saccharomyces_cerevisiae
ENSG00000159399HK29234.286YGL253WHXK29433.846Saccharomyces_cerevisiae
ENSG00000159399HK29835.208YCL040WGLK19935.208Saccharomyces_cerevisiae
ENSG00000159399HK29635.095YDR516C9535.095Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001666response to hypoxia-IEAProcess
GO:0001678cellular glucose homeostasis21873635.IBAProcess
GO:0002931response to ischemia-IEAProcess
GO:0004340glucokinase activity21873635.IBAFunction
GO:0004396hexokinase activity9278438.TASFunction
GO:0005515protein binding16189514.23185017.25416956.28054552.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005536glucose binding-IEAFunction
GO:0005741mitochondrial outer membrane18350175.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IEAComponent
GO:0006096glycolytic process21873635.IBAProcess
GO:0006096glycolytic process23962723.TASProcess
GO:0007595lactation-IEAProcess
GO:0008637apoptotic mitochondrial changes18350175.IDAProcess
GO:0008865fructokinase activity21873635.IBAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016529sarcoplasmic reticulum-IEAComponent
GO:0019158mannokinase activity21873635.IBAFunction
GO:0035795negative regulation of mitochondrial membrane permeability-IEAProcess
GO:0045766positive regulation of angiogenesis25801897.IMPProcess
GO:0046324regulation of glucose import-IEAProcess
GO:0046835carbohydrate phosphorylation-IEAProcess
GO:0051156glucose 6-phosphate metabolic process-IEAProcess
GO:0061621canonical glycolysis-TASProcess
GO:0072655establishment of protein localization to mitochondrion23962723.IMPProcess
GO:0072656maintenance of protein location in mitochondrion23962723.IMPProcess
GO:1904925positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization23962723.IMPProcess
GO:1990830cellular response to leukemia inhibitory factor-IEAProcess
GO:2000378negative regulation of reactive oxygen species metabolic process-IEAProcess
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