EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28498475	Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16E7-induced cervical cancer and suppresses tumor growth.	Int J Oncol	2017 Jun	Liu Y	doi: 10.3892/ijo.2017.3979
22825642	Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.	Arch Orthop Trauma Surg	2012 Nov	Hoshi M	doi: 10.1007/s00402-012-1588-2
24363061	Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma.	Tumour Biol	2014 Apr	Chen J	doi: 10.1007/s13277-013-1496-2
24033605	Tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.	Cancer Sci	2013 Dec	Yoshino H	doi: 10.1111/cas.12280
23071593	Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.	PLoS One	2012	Kwee SA	doi: 10.1371/journal.pone.0046591
21242296	Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.	J Exp Med	2011 Feb 14	Wolf A	doi: 10.1084/jem.20101470
19049977	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.	J Biol Chem	2009 Feb 6	Arzoine L	doi: 10.1074/jbc.M803614200
25060325	Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.	Cancer Sci	2014 Sep	Hamabe A	doi: 10.1111/cas.12487
28174335	MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2.	Biosci Rep	2017 Jun 8	Sun X	doi: 10.1042/BSR20160404
29763606	MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.	Biochem Biophys Res Commun	2018 Jul 2	Liu Y	doi: 10.1016/j.bbrc.2018.05.069
26802651	Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.	Oncol Res	2016	Xi F	doi: 10.3727/096504015X14459480491740.
22593586	MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.	J Biol Chem	2012 Jun 29	Fang R	doi: 10.1074/jbc.M112.373084
18535403	Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.	Cancer Biol Ther	2008 Jul	Peng Q	-
11688991	Identification of genes differentially induced by hypoxia in pancreatic cancer cells.	Biochem Biophys Res Commun	2001 Nov 9	Yoon DY	-
18772588	Downregulation of the hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.	Chemotherapy	2008	Peng QP	doi: 10.1159/000153655
24051093	INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.	Biochem Biophys Res Commun	2013 Oct 11	Min JW	doi: 10.1016/j.bbrc.2013.09.041
20958264	Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.	Biochem J	2011 Jan 1	Moon JS	doi: 10.1042/BJ20101104.
22691140	MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells.	BMC Cancer	2012 Jun 12	Gregersen LH	doi: 10.1186/1471-2407-12-232.
24890811	Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway.	Cancer Sci	2014 Aug	Li Z	doi: 10.1111/cas.12461.
14672622	Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.	J Hepatol	2004 Jan	Yasuda S	-
19003546	Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer.	Med Oncol	2009	He HC	doi: 10.1007/s12032-008-9120-9
15967114	[18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung.	Neoplasia	2005 Apr	Mamede M	-
21411499	Glucose metabolism gene variants modulate the risk of pancreatic cancer.	Cancer Prev Res (Phila)	2011 May	Dong X	doi: 10.1158/1940-6207.CAPR-10-0247
19723875	Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.	Mol Cancer Res	2009 Sep	Palmieri D	doi: 10.1158/1541-7786.MCR-09-0234
26607110	miR-4458 suppresses glycolysis and lactate production by directly targeting hexokinase2 in colon cancer cells.	Biochem Biophys Res Commun	2016 Jan 1	Qin Y	doi: 10.1016/j.bbrc.2015.11.066
22398711	Correlation between FDG uptake by PET/CT and the expressions of glucose transporter type 1 and hexokinase II in cervical cancer.	Int J Gynecol Cancer	2012 May	Tong SY	doi: 10.1097/IGC.0b013e31824864e6.
16551620	Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.	J Biol Chem	2006 May 19	Machida K	-
20846459	A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.	J Exp Clin Cancer Res	2010 Sep 17	Guo-Qing P	doi: 10.1186/1756-9966-29-129.
27315591	Inhibition of microRNA-155 sensitizes lung cancer cells to irradiation via suppression of HK2-modulated glucose metabolism.	Mol Med Rep	2016 Aug	Lv X	doi: 10.3892/mmr.2016.5394
28184935	Involvement of EZH2 in aerobic glycolysis of prostate cancer through miR-181b/HK2 axis.	Oncol Rep	2017 Mar	Tao T	doi: 10.3892/or.2017.5430
28347233	Glycolysis-related protein expression in thyroid cancer.	Tumour Biol	2017 Mar	Nahm JH	doi: 10.1177/1010428317695922.
28488541	MicroRNA-124 suppresses proliferation and glycolysis in non-small cell lung cancer cells by targeting AKT-GLUT1/HKII.	Tumour Biol	2017 May	Zhao X	doi: 10.1177/1010428317706215.
28025745	MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.	Dig Dis Sci	2017 Mar	Zhu W	doi: 10.1007/s10620-016-4418-5
28641488	UCA1 involved in the metformin-regulated bladder cancer cell proliferation and glycolysis.	Tumour Biol	2017 Jun	Li T	doi: 10.1177/1010428317710823.
28098871	Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.	Oncol Rep	2017 Mar	Zhang H	doi: 10.3892/or.2017.5367
29114069	BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.	J Cell Biol	2017 Dec 4	An MX	doi: 10.1083/jcb.201701064
29247711	Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy.	Int J Biochem Cell Biol	2018 Feb	Zhang XY	doi: 10.1016/j.biocel.2017.12.010
30015920	Long noncoding RNA urothelial cancer associated1 regulates radioresistance via the hexokinase2/glycolytic pathway in cervical cancer.	Int J Mol Med	2018 Oct	Fan L	doi: 10.3892/ijmm.2018.3778
28596599	The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma.	Sci Rep	2017 Jun 8	Jin F	doi: 10.1038/s41598-017-03407-3.
29985480	PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.	Oncogene	2018 Nov	Yang T	doi: 10.1038/s41388-018-0386-x
29384225	Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells.	J Cell Biochem	2018 Jun	Gao X	doi: 10.1002/jcb.26742
28980855	Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2).	Autophagy	2018	Jiao L	doi: 10.1080/15548627.2017.1381804

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	74887977	Missense_Mutation	novel	G765V	0.15
ACC	chr2	74877230	Missense_Mutation	novel	A314T	0.5
ACC	chr2	74878813	Missense_Mutation	novel	C386Y	0.34
BLCA	chr2	74877317	Missense_Mutation	novel	E343K	0.22
BLCA	chr2	74882208	Missense_Mutation	novel	S603Y	0.19
BLCA	chr2	74834606	Missense_Mutation	rs768264746	Y9F	0.71
BLCA	chr2	74834591	Missense_Mutation	NA	S4W	0.28
BLCA	chr2	74888004	Missense_Mutation	novel	E774V	0.16
BLCA	chr2	74889297	Missense_Mutation	NA	E810Q	0.16
BLCA	chr2	74888048	Nonsense_Mutation	novel	Q789*	0.2
BLCA	chr2	74882174	Nonsense_Mutation	novel	K592*	0.15
BLCA	chr2	74889431	Silent	novel	L854L	0.65
BLCA	chr2	74887909	Missense_Mutation	novel	E742D	0.29
BRCA	chr2	74878816	Missense_Mutation	novel	A387V	0.1
BRCA	chr2	74880328	Silent	NA	L443L	0.32
BRCA	chr2	74834539	5'UTR	rs760698270		0.18
BRCA	chr2	74890802	Missense_Mutation	NA	A872V	0.29
BRCA	chr2	74878685	Splice_Region	novel		0.33
BRCA	chr2	74880488	Silent	NA	R497R	0.32
BRCA	chr2	74874323	Missense_Mutation	NA	G250A	0.42
BRCA	chr2	74874424	Missense_Mutation	novel	G284C	0.09
CESC	chr2	74867641	Missense_Mutation	rs749170805	G78R	0.34
CESC	chr2	74889270	Nonsense_Mutation	NA	R801*	0.33
CESC	chr2	74880494	Silent	novel	L499L	0.25
CESC	chr2	74880328	Silent	NA	L443L	0.4
CESC	chr2	74880522	Frame_Shift_Ins	novel	*V509Gfs69**	0.08
CESC	chr2	74878843	Missense_Mutation	novel	R396H	0.42
CESC	chr2	74880528	Missense_Mutation	novel	K510R	0.11
CESC	chr2	74881749	Missense_Mutation	novel	N537D	0.29
CESC	chr2	74872339	Missense_Mutation	novel	D139N	0.08
CESC	chr2	74892085	3'UTR	novel		0.24
CESC	chr2	74834539	5'UTR	rs760698270		0.32
CESC	chr2	74881754	Missense_Mutation	NA	F538L	0.25
CESC	chr2	74874280	Missense_Mutation	NA	A236S	0.3
CHOL	chr2	74873292	Missense_Mutation	novel	W171L	0.53
CHOL	chr2	74891805	3'UTR	rs573140147		0.17
COAD	chr2	74889450	Missense_Mutation	NA	D861Y	0.38
COAD	chr2	74880383	Missense_Mutation	novel	R462W	0.17
COAD	chr2	74889312	Missense_Mutation	novel	D815N	0.09
COAD	chr2	74886532	Missense_Mutation	novel	V693A	0.35
COAD	chr2	74854317	Missense_Mutation	rs567201785	R30C	0.37
COAD	chr2	74878871	Silent	rs779743587	R405R	0.36
COAD	chr2	74874309	Silent	rs373457354	I245I	0.39
COAD	chr2	74877228	Missense_Mutation	NA	M313T	0.32
COAD	chr2	74881771	Missense_Mutation	rs62642507	R544H	0.18
COAD	chr2	74886526	Missense_Mutation	rs746400081	R691H	0.2
COAD	chr2	74881743	Nonsense_Mutation	NA	G535*	0.31
COAD	chr2	74881739	Silent	novel	L533L	0.16
COAD	chr2	74873326	Silent	novel	G182G	0.32
COAD	chr2	74880293	Missense_Mutation	rs148796379	R432W	0.14
COAD	chr2	74881803	In_Frame_Ins	novel	M555delinsTV	0.09
COAD	chr2	74881805	Missense_Mutation	novel	M555I	0.05
COAD	chr2	74881820	Silent	rs369669565	Y560Y	0.26
COAD	chr2	74890891	Missense_Mutation	NA	A902T	0.27
ESCA	chr2	74891806	3'UTR	novel		0.36
ESCA	chr2	74867681	Missense_Mutation	rs746133519	R91H	0.14
ESCA	chr2	74834543	5'UTR	novel		0.52
ESCA	chr2	74888001	Missense_Mutation	novel	S773L	0.43
GBM	chr2	74854304	Nonsense_Mutation	novel	Y25*	0.08
GBM	chr2	74880467	Missense_Mutation	novel	R490G	0.21
GBM	chr2	74854317	Missense_Mutation	rs567201785	R30C	0.08
GBM	chr2	74887982	Missense_Mutation	novel	L767I	0.31
GBM	chr2	74889312	Missense_Mutation	novel	D815N	0.61
GBM	chr2	74877243	Missense_Mutation	novel	L318R	0.31
GBM	chr2	74886558	Missense_Mutation	NA	R702W	0.3
GBM	chr2	74873299	Missense_Mutation	novel	K173N	0.12
GBM	chr2	74889271	Missense_Mutation	rs28363057	R801Q	0.55
GBM	chr2	74888056	Splice_Site	novel	X791_splice	0.07
HNSC	chr2	74834532	5'UTR	novel		0.09
HNSC	chr2	74834583	Translation_Start_Site	novel	M1?	0.11
HNSC	chr2	74890798	Frame_Shift_Del	novel	*F871Lfs9**	0.54
HNSC	chr2	74873289	Nonsense_Mutation	novel	S170*	0.14
HNSC	chr2	74889352	Missense_Mutation	rs148653106	R828Q	0.37
HNSC	chr2	74888030	Missense_Mutation	novel	E783Q	0.22
HNSC	chr2	74880312	Missense_Mutation	novel	C438F	0.25
LAML	chr2	74880486	Missense_Mutation	novel	E496V	0.46
LGG	chr2	74886493	Missense_Mutation	rs138539339	T680M	0.3
LGG	chr2	74880562	Silent	rs144796715	D521D	0.26
LGG	chr2	74880384	Missense_Mutation	novel	R462Q	0.41
LGG	chr2	74886559	Missense_Mutation	rs767300432	R702Q	0.35
LIHC	chr2	74882236	Silent	rs200225889	D612D	0.1
LIHC	chr2	74886508	Missense_Mutation	NA	C685F	0.41
LIHC	chr2	74880281	Missense_Mutation	novel	H428D	0.46
LIHC	chr2	74877241	Silent	NA	E317E	0.23
LIHC	chr2	74886365	Silent	novel	D669D	0.36
LIHC	chr2	74886654	Missense_Mutation	NA	L734F	0.52
LIHC	chr2	74854327	Missense_Mutation	novel	D33G	0.1
LUAD	chr2	74890857	Silent	NA	F890F	0.14
LUAD	chr2	74886505	Missense_Mutation	NA	A684V	0.2
LUAD	chr2	74877287	Missense_Mutation	rs750616279	R333C	0.08
LUAD	chr2	74889356	Silent	NA	R829R	0.31
LUAD	chr2	74873317	Silent	novel	G179G	0.08
LUAD	chr2	74882158	Silent	NA	L586L	0.17
LUAD	chr2	74886624	Missense_Mutation	NA	E724K	0.13
LUAD	chr2	74886663	Missense_Mutation	novel	G737S	0.07
LUAD	chr2	74872337	Missense_Mutation	NA	M138T	0.26
LUAD	chr2	74890922	Missense_Mutation	NA	R912L	0.56
LUAD	chr2	74887934	Missense_Mutation	NA	G751C	0.54
LUAD	chr2	74880524	Missense_Mutation	rs763634644	V509I	0.26
LUAD	chr2	74886347	Missense_Mutation	novel	M663I	0.27
LUSC	chr2	74885530	Missense_Mutation	novel	S626T	0.44
LUSC	chr2	74890916	Missense_Mutation	rs770307123	R910H	0.33
LUSC	chr2	74889368	Silent	novel	L833L	0.15
LUSC	chr2	74874302	Missense_Mutation	NA	R243L	0.23
LUSC	chr2	74890853	Missense_Mutation	rs764837491	S889C	0.15
LUSC	chr2	74889253	Frame_Shift_Del	novel	*L795Rfs10**	0.42
LUSC	chr2	74886541	Missense_Mutation	NA	V696E	0.13
LUSC	chr2	74878798	Missense_Mutation	novel	R381L	0.25
LUSC	chr2	74880521	Missense_Mutation	novel	P508S	0.29
LUSC	chr2	74881752	Missense_Mutation	novel	F538I	0.07
LUSC	chr2	74887923	Missense_Mutation	novel	G747E	0.4
LUSC	chr2	74880294	Missense_Mutation	rs773701506	R432Q	0.33
LUSC	chr2	74854393	Missense_Mutation	novel	T55I	0.36
LUSC	chr2	74887907	Missense_Mutation	NA	E742Q	0.09
OV	chr2	74878695	Missense_Mutation	novel	D347N	0.36
OV	chr2	74891000	3'UTR	novel		0.14
OV	chr2	74854449	Missense_Mutation	NA	G74W	0.43
OV	chr2	74881725	Silent	novel	L529L	0.05
OV	chr2	74881758	Missense_Mutation	novel	V540L	0.18
OV	chr2	74877216	Missense_Mutation	novel	I309T	0.06
OV	chr2	74891759	3'UTR	novel		0.33
OV	chr2	74890820	Missense_Mutation	novel	T878I	0.03
OV	chr2	74890822	Missense_Mutation	novel	V879M	0.02
OV	chr2	74889414	Missense_Mutation	rs750043718	R849C	0.44
PAAD	chr2	74867635	Splice_Site	novel	X76_splice	0.17
PAAD	chr2	74878714	Missense_Mutation	novel	R353H	0.35
PRAD	chr2	74854305	Missense_Mutation	NA	L26I	0.37
PRAD	chr2	74887973	Missense_Mutation	rs767373447	R764C	0.34
READ	chr2	74886524	Missense_Mutation	novel	M690I	0.28
READ	chr2	74880503	Missense_Mutation	rs199889864	E502K	0.17
SARC	chr2	74880451	Silent	novel	L484L	0.4
SARC	chr2	74888048	Missense_Mutation	rs780880800	Q789E	0.26
SARC	chr2	74867680	Missense_Mutation	rs371320494	R91C	0.16
SKCM	chr2	74877266	Missense_Mutation	novel	P326S	0.23
SKCM	chr2	74877267	Missense_Mutation	novel	P326L	0.24
SKCM	chr2	74881827	Missense_Mutation	NA	P563S	0.21
SKCM	chr2	74885545	Missense_Mutation	rs780187573	E631K	0.39
SKCM	chr2	74885547	Silent	novel	E631E	0.38
SKCM	chr2	74872394	Missense_Mutation	NA	P157L	0.36
SKCM	chr2	74874380	Missense_Mutation	rs772185128	S269L	0.56
SKCM	chr2	74890857	Silent	NA	F890F	0.24
SKCM	chr2	74880329	Missense_Mutation	rs573942688	R444C	0.34
SKCM	chr2	74888026	Silent	NA	I781I	0.31
SKCM	chr2	74867752	Missense_Mutation	NA	P115S	0.31
SKCM	chr2	74880522	Missense_Mutation	novel	P508L	0.33
SKCM	chr2	74880523	Silent	rs142174869	P508P	0.34
SKCM	chr2	74887956	Missense_Mutation	NA	L758P	0.19
SKCM	chr2	74887968	Missense_Mutation	NA	T762I	0.25
SKCM	chr2	74877275	Missense_Mutation	NA	L329F	0.11
SKCM	chr2	74882128	Silent	NA	D576D	0.14
SKCM	chr2	74877246	Missense_Mutation	novel	L319H	0.22
SKCM	chr2	74873365	Silent	NA	R195R	0.12
SKCM	chr2	74873908	Missense_Mutation	NA	Y219F	0.17
SKCM	chr2	74889406	Missense_Mutation	rs767145519	R846Q	0.51
SKCM	chr2	74887945	Silent	novel	V754V	0.05
SKCM	chr2	74881832	Silent	NA	Q564Q	0.38
SKCM	chr2	74882212	Silent	NA	F604F	0.06
SKCM	chr2	74873298	Missense_Mutation	novel	K173M	0.25
SKCM	chr2	74873299	Silent	novel	K173K	0.25
SKCM	chr2	74874295	Missense_Mutation	novel	E241K	0.24
STAD	chr2	74873337	Missense_Mutation	NA	V186A	0.11
STAD	chr2	74885532	Silent	NA	S626S	0.15
STAD	chr2	74867768	Missense_Mutation	NA	R120Q	0.31
STAD	chr2	74867659	Missense_Mutation	novel	D84Y	0.45
STAD	chr2	74873938	Missense_Mutation	NA	I229T	0.19
STAD	chr2	74886526	Missense_Mutation	rs746400081	R691H	0.3
STAD	chr2	74834596	Silent	NA	L6L	0.28
STAD	chr2	74874280	Missense_Mutation	NA	A236T	0.22
STAD	chr2	74880290	Frame_Shift_Del	novel	*V431Cfs26**	0.21
STAD	chr2	74881837	Missense_Mutation	novel	V566A	0.18
STAD	chr2	74889342	Missense_Mutation	NA	V825M	0.16
STAD	chr2	74889456	Missense_Mutation	NA	T863A	0.27
STAD	chr2	74889316	Missense_Mutation	NA	S816N	0.23
STAD	chr2	74872316	Missense_Mutation	novel	A131V	0.53
STAD	chr2	74874271	Missense_Mutation	novel	G233C	0.41
UCEC	chr2	74874433	Missense_Mutation	NA	N287D	0.32
UCEC	chr2	74890879	Missense_Mutation	novel	G898R	0.59
UCEC	chr2	74887929	Missense_Mutation	novel	Y749C	0.31
UCEC	chr2	74889312	Missense_Mutation	novel	D815N	0.25
UCEC	chr2	74854318	Missense_Mutation	novel	R30L	0.07
UCEC	chr2	74890884	Frame_Shift_Del	rs771887254	*A901Rfs74**	0.37
UCEC	chr2	74867681	Missense_Mutation	rs746133519	R91H	0.06
UCEC	chr2	74889329	Missense_Mutation	novel	K820N	0.43
UCEC	chr2	74880274	Missense_Mutation	novel	K425N	0.42
UCEC	chr2	74873275	Splice_Site	novel	X166_splice	0.35
UCEC	chr2	74877313	Silent	rs749637190	D341D	0.52
UCEC	chr2	74880383	Missense_Mutation	novel	R462W	0.36
UCEC	chr2	74886336	Missense_Mutation	rs763967521	G660R	0.52
UCEC	chr2	74880541	Silent	novel	T514T	0.14
UCEC	chr2	74882236	Silent	rs200225889	D612D	0.29
UCEC	chr2	74890954	3'UTR	novel		0.27
UCEC	chr2	74889446	Silent	novel	G859G	0.42
UCEC	chr2	74890890	Silent	rs779051510	A901A	0.29
UCEC	chr2	74885555	Missense_Mutation	NA	V634A	0.35
UCEC	chr2	74887907	Missense_Mutation	novel	E742K	0.32
UCEC	chr2	74890805	Missense_Mutation	novel	K873T	0.23
UCEC	chr2	74867721	Missense_Mutation	novel	K104N	0.09
UCEC	chr2	74881827	Missense_Mutation	NA	P563S	0.33
UCEC	chr2	74886490	Missense_Mutation	rs765371876	G679D	0.27
UCEC	chr2	74890986	3'UTR	novel		0.25
UCEC	chr2	74892042	3'UTR	novel		0.22
UCEC	chr2	74867775	Silent	novel	S122S	0.2
UCEC	chr2	74892117	3'UTR	novel		0.53
UCEC	chr2	74891686	3'UTR	novel		1
UCEC	chr2	74873856	Missense_Mutation	NA	D202N	0.51
UCEC	chr2	74882179	Silent	rs532190486	G593G	0.49
UCEC	chr2	74886336	Missense_Mutation	rs763967521	G660R	0.41
UCEC	chr2	74887974	Missense_Mutation	rs527493699	R764H	0.48
UCEC	chr2	74891882	3'UTR	novel		0.39
UCEC	chr2	74867727	Missense_Mutation	novel	E106D	0.49
UCEC	chr2	74873856	Missense_Mutation	NA	D202N	0.53
UCEC	chr2	74877288	Missense_Mutation	rs756426288	R333H	0.11
UCEC	chr2	74878892	Silent	rs749015495	V412V	0.29
UCEC	chr2	74888014	Missense_Mutation	novel	K777N	0.08
UCEC	chr2	74834587	Missense_Mutation	novel	A3P	0.04
UCEC	chr2	74890916	Missense_Mutation	rs770307123	R910H	0.38
UCEC	chr2	74872417	Missense_Mutation	novel	E165K	0.33
UCEC	chr2	74881829	Silent	rs769749367	P563P	0.32
UCEC	chr2	74886619	Missense_Mutation	rs773823434	R722H	0.19
UCEC	chr2	74874285	Silent	novel	C237C	0.15
UCEC	chr2	74854354	Missense_Mutation	rs375609405	R42Q	0.39
UCEC	chr2	74890850	Missense_Mutation	rs759264948	V888A	0.31
UCEC	chr2	74889311	Silent	rs761447119	D814D	0.14
UCEC	chr2	74890815	Silent	NA	H876H	0.21
UCEC	chr2	74880321	Missense_Mutation	novel	R441H	0.39
UCEC	chr2	74867768	Missense_Mutation	NA	R120Q	0.36
UCEC	chr2	74886525	Missense_Mutation	rs147295617	R691C	0.16
UCEC	chr2	74889271	Missense_Mutation	rs28363057	R801Q	0.29
UCEC	chr2	74834627	Missense_Mutation	NA	H16R	0.31
UCEC	chr2	74890796	Splice_Site	NA	X870_splice	0.27
UCEC	chr2	74874355	Missense_Mutation	novel	W261R	0.27
UCS	chr2	74886622	Missense_Mutation	novel	T723I	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0489	0.2014
READ	DEL	0.0727	0.19022

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0062	Kaplan-Meier Survival Analysis
ACC	0.0011	Kaplan-Meier Survival Analysis
ESCA	0.032	Kaplan-Meier Survival Analysis
KIRP	0.032	Kaplan-Meier Survival Analysis
PAAD	0.01	Kaplan-Meier Survival Analysis
CESC	0.00091	Kaplan-Meier Survival Analysis
LAML	0.00079	Kaplan-Meier Survival Analysis
KICH	0.029	Kaplan-Meier Survival Analysis
LIHC	0.0046	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0024	Kaplan-Meier Survival Analysis
UVM	0.043	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000159399 (Gene tree)
Gene ID: 3099
Gene Symbol: HK2
Alias: N
Full Name: hexokinase 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 60,705 bases
Position: chr2:74,832,655-74,893,359
Accession: 4923
Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26247723	Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein.	Cell Death Dis	2015 Aug 6	Courteau L	doi: 10.1038/cddis.2015.209.
29114069	BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.	J Cell Biol	2017 Dec 4	An MX	doi: 10.1083/jcb.201701064

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409174	HK2-202	5278	-	ENSP00000387140	889 (aa)	-	E9PB90
ENST00000290573	HK2-201	5772	XM_005264280	ENSP00000290573	917 (aa)	XP_005264337	P52789
ENST00000472302	HK2-203	395	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000159399's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00051	Fructose and mannose metabolism	KEGG
hsa00052	Galactose metabolism	KEGG
hsa00500	Starch and sucrose metabolism	KEGG
hsa00520	Amino sugar and nucleotide sugar metabolism	KEGG
hsa00524	Neomycin, kanamycin and gentamicin biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04930	Type II diabetes mellitus	KEGG
hsa04973	Carbohydrate digestion and absorption	KEGG
hsa05230	Central carbon metabolism in cancer	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000159399	Echocardiography	8.66735298510335E-6	17903301
ENSG00000159399	Echocardiography	7.56992495265507E-6	17903301
ENSG00000159399	Child Development Disorders, Pervasive	6.2042500E-005	-
ENSG00000159399	Child Development Disorders, Pervasive	4.1128000E-005	-
ENSG00000159399	Femur Neck	3E-6	22087292

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000159399	rs681900	2	74847840	?	Femoral neck bone geometry	22087292			EFO_0004511

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159399's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000159399	HK2	99	73.982	ENSG00000156515	HK1	99	73.982	Homo_sapiens
ENSG00000159399	HK2	100	94.713	ENSMUSG00000000628	Hk2	100	97.674	Mus_musculus
ENSG00000159399	HK2	96	35.841	YFR053C		91	35.683	Saccharomyces_cerevisiae
ENSG00000159399	HK2	92	34.286	YGL253W	HXK2	94	33.846	Saccharomyces_cerevisiae
ENSG00000159399	HK2	98	35.208	YCL040W	GLK1	99	35.208	Saccharomyces_cerevisiae
ENSG00000159399	HK2	96	35.095	YDR516C		95	35.095	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001666	response to hypoxia	-	IEA	Process
GO:0001678	cellular glucose homeostasis	21873635.	IBA	Process
GO:0002931	response to ischemia	-	IEA	Process
GO:0004340	glucokinase activity	21873635.	IBA	Function
GO:0004396	hexokinase activity	9278438.	TAS	Function
GO:0005515	protein binding	16189514.23185017.25416956.28054552.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005536	glucose binding	-	IEA	Function
GO:0005741	mitochondrial outer membrane	18350175.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006096	glycolytic process	21873635.	IBA	Process
GO:0006096	glycolytic process	23962723.	TAS	Process
GO:0007595	lactation	-	IEA	Process
GO:0008637	apoptotic mitochondrial changes	18350175.	IDA	Process
GO:0008865	fructokinase activity	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016529	sarcoplasmic reticulum	-	IEA	Component
GO:0019158	mannokinase activity	21873635.	IBA	Function
GO:0035795	negative regulation of mitochondrial membrane permeability	-	IEA	Process
GO:0045766	positive regulation of angiogenesis	25801897.	IMP	Process
GO:0046324	regulation of glucose import	-	IEA	Process
GO:0046835	carbohydrate phosphorylation	-	IEA	Process
GO:0051156	glucose 6-phosphate metabolic process	-	IEA	Process
GO:0061621	canonical glycolysis	-	TAS	Process
GO:0072655	establishment of protein localization to mitochondrion	23962723.	IMP	Process
GO:0072656	maintenance of protein location in mitochondrion	23962723.	IMP	Process
GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	23962723.	IMP	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process
GO:2000378	negative regulation of reactive oxygen species metabolic process	-	IEA	Process

EuRBPDB

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.