EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	22034510	Missense_Mutation	novel	K178E	0.18
BLCA	chr8	22034538	Missense_Mutation	novel	E187A	0.41
CESC	chr8	22025290	Silent	rs372304710	V14V	0.14
COAD	chr8	22025696	Missense_Mutation	NA	L65R	0.3	Nucleoplasmin
COAD	chr8	22025732	Missense_Mutation	rs756290241	P77L	0.21	Nucleoplasmin
COAD	chr8	22036696	3'UTR	novel		0.56
COAD	chr8	22025461	Silent	NA	R28R	0.35
ESCA	chr8	22034509	Frame_Shift_Ins	rs770540772	*L181Afs13**	0.78
ESCA	chr8	22036750	3'UTR	novel		0.71
GBM	chr8	22034214	Missense_Mutation	novel	E157V	0.09
HNSC	chr8	22025759	Nonsense_Mutation	novel	S86*	0.26	Nucleoplasmin
HNSC	chr8	22034263	Silent	novel	A173A	0.09
LAML	chr8	22036529	Splice_Region	NA		0.14
LIHC	chr8	22036788	3'UTR	novel		0.42
LIHC	chr8	22036717	3'UTR	novel		0.38
LIHC	chr8	22034111	Missense_Mutation	novel	A123S	0.42
LUAD	chr8	22034261	Missense_Mutation	novel	A173S	0.14
LUAD	chr8	22033205	Missense_Mutation	NA	S116C	0.38
LUAD	chr8	22033160	Missense_Mutation	rs752056694	P101S	0.15
LUSC	chr8	22025167	Intron	novel		0.27
LUSC	chr8	22025716	Missense_Mutation	novel	D72N	0.56	Nucleoplasmin
LUSC	chr8	22025461	Silent	NA	R28R	0.5
OV	chr8	22025212	Splice_Region	novel		0.41
OV	chr8	22025504	Missense_Mutation	novel	R43G	0.83	Nucleoplasmin
SARC	chr8	22033190	Missense_Mutation	novel	G111R	0.07
SKCM	chr8	22033214	Missense_Mutation	rs773383353	E119K	0.4
SKCM	chr8	22025218	Splice_Region	novel		0.32
SKCM	chr8	22034249	Missense_Mutation	NA	P169S	0.33
SKCM	chr8	22034256	Missense_Mutation	NA	K171T	0.24
SKCM	chr8	22034250	Missense_Mutation	novel	P169L	0.79
SKCM	chr8	22034251	Silent	novel	P169P	0.79
SKCM	chr8	22034222	Missense_Mutation	NA	P160S	0.15
SKCM	chr8	22033177	Silent	novel	L106L	0.68
STAD	chr8	22034508	Splice_Site	NA	X178_splice	0.05
STAD	chr8	22025459	Missense_Mutation	NA	R28W	0.18	Nucleoplasmin
STAD	chr8	22025770	Missense_Mutation	rs775998097	M90V	0.2	Nucleoplasmin
UCEC	chr8	22025513	Missense_Mutation	novel	L46F	0.5	Nucleoplasmin
UCEC	chr8	22034211	Missense_Mutation	novel	E156G	0.14
UCEC	chr8	22025505	Missense_Mutation	novel	R43M	0.44	Nucleoplasmin
UCEC	chr8	22025263	Silent	rs748152197	S5S	0.22
UCEC	chr8	22025773	Splice_Site	NA	X90_splice	0.3
UCEC	chr8	22033176	Missense_Mutation	NA	L106R	0.13
UCEC	chr8	22034117	Missense_Mutation	novel	D125Y	0.44
UCEC	chr8	22025149	Intron	novel		0.11
UCEC	chr8	22036499	Silent	rs199619291	S191S	0.14
UCEC	chr8	22025507	Silent	novel	L44L	0.09
UCEC	chr8	22036732	3'UTR	novel		0.23
UCEC	chr8	22025684	Missense_Mutation	NA	R61H	0.28	Nucleoplasmin
UCEC	chr8	22033192	Silent	novel	G111G	0.18
UCEC	chr8	22034262	Missense_Mutation	rs376012931	A173V	0.39
UCEC	chr8	22034118	Missense_Mutation	rs573320759	D125G	0.06
UCEC	chr8	22034519	Silent	novel	L181L	0.21
UCEC	chr8	22025513	Missense_Mutation	novel	L46F	0.3	Nucleoplasmin
UCEC	chr8	22034140	Silent	rs777907377	E132E	0.18
UCEC	chr8	22036668	Nonsense_Mutation	novel	G211*	0.4
UCEC	chr8	22025452	Missense_Mutation	novel	Q25H	0.29	Nucleoplasmin
UCEC	chr8	22034221	Silent	novel	S159S	0.38
UCEC	chr8	22025503	Silent	novel	C42C	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5613	4.5185e-08
DLBC	DEL	0.25	0.15679
ESCA	DEL	0.413	0.060925
PAAD	DEL	0.2446	0.050455
PRAD	DEL	0.5589	5.8548e-30
READ	DEL	0.5697	0.20625
UCS	DEL	0.5179	0.0031922

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0037	Kaplan-Meier Survival Analysis
UCS	0.047	Kaplan-Meier Survival Analysis
SKCM	0.0092	Kaplan-Meier Survival Analysis
KIRP	0.005	Kaplan-Meier Survival Analysis
PAAD	0.005	Kaplan-Meier Survival Analysis
UCEC	0.049	Kaplan-Meier Survival Analysis
LGG	0.00072	Kaplan-Meier Survival Analysis
UVM	0.0061	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000158806 (Gene tree)
Gene ID: 10361
Gene Symbol: NPM2
Alias: N
Full Name: nucleophosmin/nucleoplasmin 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 13,190 bases
Position: chr8:22,023,708-22,036,897
Accession: 7930
Summary: (Nucleophosmin/Nucleoplasmin 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and enzyme binding. An important paralog of this gene is NPM1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000428016	Nucleoplasmin	PF03066.15	1e-34	1	1
ENSP00000370941	Nucleoplasmin	PF03066.15	1.1e-34	1	1
ENSP00000481018	Nucleoplasmin	PF03066.15	1.1e-34	1	1
ENSP00000289820	Nucleoplasmin	PF03066.15	5.2e-34	1	1
ENSP00000381032	Nucleoplasmin	PF03066.15	5.2e-34	1	1
ENSP00000427741	Nucleoplasmin	PF03066.15	5.2e-34	1	1
ENSP00000429413	Nucleoplasmin	PF03066.15	5.2e-34	1	1
ENSP00000481077	Nucleoplasmin	PF03066.15	5.2e-34	1	1
ENSP00000429984	Nucleoplasmin	PF03066.15	6.1e-21	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000289820	NPM2-201	1100	-	ENSP00000289820	214 (aa)	-	Q86SE8
ENST00000397940	NPM2-203	1874	XM_011544364	ENSP00000381032	214 (aa)	XP_011542666	Q86SE8
ENST00000615914	NPM2-213	411	-	ENSP00000481018	136 (aa)	-	Q86SE8
ENST00000521157	NPM2-209	1484	XM_011544360	ENSP00000429413	214 (aa)	XP_011542662	Q86SE8
ENST00000522953	NPM2-211	373	-	-	- (aa)	-	-
ENST00000520180	NPM2-207	417	-	-	- (aa)	-	-
ENST00000520125	NPM2-206	570	-	ENSP00000429984	99 (aa)	-	E5RGN1
ENST00000518119	NPM2-204	1190	-	ENSP00000427741	214 (aa)	-	Q86SE8
ENST00000524322	NPM2-212	178	-	-	- (aa)	-	-
ENST00000621538	NPM2-214	645	-	ENSP00000481077	214 (aa)	-	Q86SE8
ENST00000519373	NPM2-205	520	-	-	- (aa)	-	-
ENST00000522813	NPM2-210	565	-	ENSP00000428016	137 (aa)	-	E5RFQ8
ENST00000381530	NPM2-202	925	-	ENSP00000370941	136 (aa)	-	Q86SE8
ENST00000520456	NPM2-208	497	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000158806's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000158806	Birth Weight	5E-6	23251661
ENSG00000158806	Cerebrospinal Fluid	1E-16	28031287

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000158806	rs12550716	8	22031059	?	Cerebrospinal fluid biomarker levels	28031287			EFO_0006794
ENSG00000158806	rs11776272	8	22027033	G	Obesity-related traits	23251661	[NR] kg increase	0.05	EFO_0004344

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000158806's network

Paralog

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000158806	NPM2	76	39.423	ENSG00000181163	NPM1	68	30.055
ENSG00000158806	NPM2	84	36.145	ENSG00000107833	NPM3	70	38.889

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000158806	NPM2	89	62.500	ENSAMEG00000001239	-	99	48.815	Ailuropoda_melanoleuca
ENSG00000158806	NPM2	91	69.192	ENSAMEG00000003542	-	91	69.697	Ailuropoda_melanoleuca
ENSG00000158806	NPM2	99	46.043	ENSACAG00000000163	-	84	42.778	Anolis_carolinensis
ENSG00000158806	NPM2	93	80.597	ENSANAG00000028994	-	80	82.105	Aotus_nancymaae
ENSG00000158806	NPM2	100	92.929	ENSANAG00000038138	-	99	91.852	Aotus_nancymaae
ENSG00000158806	NPM2	93	39.000	ENSAMXG00000038475	npm2b	54	39.815	Astyanax_mexicanus
ENSG00000158806	NPM2	85	39.655	ENSAMXG00000001084	npm2a	76	40.678	Astyanax_mexicanus
ENSG00000158806	NPM2	100	63.636	ENSBTAG00000046918	NPM2	94	64.249	Bos_taurus
ENSG00000158806	NPM2	100	90.909	ENSCJAG00000020389	NPM2	99	89.630	Callithrix_jacchus
ENSG00000158806	NPM2	99	65.566	ENSCAFG00020015227	-	91	68.844	Canis_lupus_dingo
ENSG00000158806	NPM2	98	62.085	ENSCAFG00020015318	-	98	61.137	Canis_lupus_dingo
ENSG00000158806	NPM2	51	70.423	ENSCAFG00020017926	-	97	63.281	Canis_lupus_dingo
ENSG00000158806	NPM2	99	63.551	ENSCAFG00020007666	-	94	62.617	Canis_lupus_dingo
ENSG00000158806	NPM2	96	67.368	ENSCAFG00020015194	-	98	63.507	Canis_lupus_dingo
ENSG00000158806	NPM2	100	64.646	ENSCHIG00000026056	NPM2	87	66.477	Capra_hircus
ENSG00000158806	NPM2	99	79.259	ENSTSYG00000026275	NPM2	99	79.259	Carlito_syrichta
ENSG00000158806	NPM2	81	66.964	ENSCAPG00000006057	NPM2	82	64.557	Cavia_aperea
ENSG00000158806	NPM2	81	66.964	ENSCPOG00000039799	NPM2	82	64.557	Cavia_porcellus
ENSG00000158806	NPM2	100	90.909	ENSCCAG00000035076	NPM2	99	90.370	Cebus_capucinus
ENSG00000158806	NPM2	100	97.980	ENSCATG00000031833	NPM2	100	97.059	Cercocebus_atys
ENSG00000158806	NPM2	100	59.596	ENSCLAG00000013600	NPM2	93	62.011	Chinchilla_lanigera
ENSG00000158806	NPM2	100	97.980	ENSCSAG00000016588	NPM2	100	96.296	Chlorocebus_sabaeus
ENSG00000158806	NPM2	56	68.908	ENSCHOG00000012753	-	86	71.963	Choloepus_hoffmanni
ENSG00000158806	NPM2	100	98.990	ENSCANG00000040109	NPM2	100	97.059	Colobus_angolensis_palliatus
ENSG00000158806	NPM2	88	71.579	ENSCGRG00001002208	Npm2	92	67.337	Cricetulus_griseus_chok1gshd
ENSG00000158806	NPM2	88	71.579	ENSCGRG00000005105	Npm2	92	67.337	Cricetulus_griseus_crigri
ENSG00000158806	NPM2	83	32.927	ENSDARG00000076391	npm2a	69	38.793	Danio_rerio
ENSG00000158806	NPM2	92	36.264	ENSDARG00000053963	npm2b	59	40.541	Danio_rerio
ENSG00000158806	NPM2	98	63.033	ENSDORG00000012371	Npm2	91	66.667	Dipodomys_ordii
ENSG00000158806	NPM2	100	71.717	ENSEASG00005018856	NPM2	100	69.792	Equus_asinus_asinus
ENSG00000158806	NPM2	100	71.717	ENSECAG00000024685	NPM2	100	68.203	Equus_caballus
ENSG00000158806	NPM2	92	37.363	ENSELUG00000004822	npm2b	62	40.541	Esox_lucius
ENSG00000158806	NPM2	99	37.755	ENSELUG00000017306	-	88	42.017	Esox_lucius
ENSG00000158806	NPM2	100	74.747	ENSFCAG00000045117	NPM2	88	70.455	Felis_catus
ENSG00000158806	NPM2	96	66.316	ENSFDAG00000007971	NPM2	90	68.605	Fukomys_damarensis
ENSG00000158806	NPM2	95	48.462	ENSGALG00000050870	NPM2	64	47.692	Gallus_gallus
ENSG00000158806	NPM2	92	38.462	ENSGALG00000054664	-	72	43.750	Gallus_gallus
ENSG00000158806	NPM2	100	100.000	ENSGGOG00000007071	NPM2	100	100.000	Gorilla_gorilla
ENSG00000158806	NPM2	87	69.748	ENSHGLG00000006243	NPM2	88	65.969	Heterocephalus_glaber_female
ENSG00000158806	NPM2	87	69.748	ENSHGLG00100005664	NPM2	89	63.776	Heterocephalus_glaber_male
ENSG00000158806	NPM2	85	38.261	ENSIPUG00000013175	npm2b	62	38.739	Ictalurus_punctatus
ENSG00000158806	NPM2	83	36.585	ENSIPUG00000010101	npm2a	71	40.171	Ictalurus_punctatus
ENSG00000158806	NPM2	100	68.807	ENSSTOG00000013623	NPM2	93	69.802	Ictidomys_tridecemlineatus
ENSG00000158806	NPM2	100	66.204	ENSJJAG00000018214	Npm2	81	67.614	Jaculus_jaculus
ENSG00000158806	NPM2	93	45.038	ENSLACG00000016196	NPM2	73	45.385	Latimeria_chalumnae
ENSG00000158806	NPM2	95	37.234	ENSLOCG00000014878	npm2b	59	43.697	Lepisosteus_oculatus
ENSG00000158806	NPM2	100	75.758	ENSLAFG00000015584	NPM2	100	70.046	Loxodonta_africana
ENSG00000158806	NPM2	100	97.980	ENSMFAG00000032098	NPM2	100	97.059	Macaca_fascicularis
ENSG00000158806	NPM2	100	97.980	ENSMMUG00000002034	NPM2	100	97.059	Macaca_mulatta
ENSG00000158806	NPM2	100	97.980	ENSMNEG00000010994	NPM2	100	97.059	Macaca_nemestrina
ENSG00000158806	NPM2	100	97.980	ENSMLEG00000030071	NPM2	100	97.059	Mandrillus_leucophaeus
ENSG00000158806	NPM2	100	68.687	ENSMAUG00000004228	Npm2	92	68.844	Mesocricetus_auratus
ENSG00000158806	NPM2	100	80.147	ENSMICG00000030722	-	99	80.147	Microcebus_murinus
ENSG00000158806	NPM2	97	70.677	ENSMOCG00000017251	Npm2	93	70.056	Microtus_ochrogaster
ENSG00000158806	NPM2	90	50.769	ENSMODG00000009677	-	95	51.613	Monodelphis_domestica
ENSG00000158806	NPM2	75	43.558	ENSMODG00000004175	-	77	41.912	Monodelphis_domestica
ENSG00000158806	NPM2	100	64.352	MGP_CAROLIEiJ_G0019492	Npm2	92	62.814	Mus_caroli
ENSG00000158806	NPM2	100	65.741	ENSMUSG00000047911	Npm2	99	65.341	Mus_musculus
ENSG00000158806	NPM2	100	64.352	MGP_PahariEiJ_G0030509	Npm2	92	64.824	Mus_pahari
ENSG00000158806	NPM2	100	65.278	MGP_SPRETEiJ_G0020384	Npm2	92	63.819	Mus_spretus
ENSG00000158806	NPM2	100	68.687	ENSMPUG00000004012	NPM2	100	67.873	Mustela_putorius_furo
ENSG00000158806	NPM2	96	70.526	ENSMLUG00000016075	NPM2	82	69.186	Myotis_lucifugus
ENSG00000158806	NPM2	98	72.857	ENSNGAG00000022056	Npm2	92	72.222	Nannospalax_galili
ENSG00000158806	NPM2	100	96.324	ENSNLEG00000035765	NPM2	100	96.324	Nomascus_leucogenys
ENSG00000158806	NPM2	100	61.616	ENSOPRG00000012940	NPM2	100	61.860	Ochotona_princeps
ENSG00000158806	NPM2	100	59.000	ENSODEG00000006433	NPM2	81	63.483	Octodon_degus
ENSG00000158806	NPM2	100	49.020	ENSOANG00000020262	-	79	54.749	Ornithorhynchus_anatinus
ENSG00000158806	NPM2	100	73.737	ENSOCUG00000021756	NPM2	100	64.486	Oryctolagus_cuniculus
ENSG00000158806	NPM2	100	77.778	ENSOGAG00000011562	NPM2	93	74.129	Otolemur_garnettii
ENSG00000158806	NPM2	100	100.000	ENSPPAG00000040749	NPM2	100	98.598	Pan_paniscus
ENSG00000158806	NPM2	99	77.037	ENSPPRG00000022157	NPM2	99	77.037	Panthera_pardus
ENSG00000158806	NPM2	85	79.310	ENSPTIG00000011553	NPM2	95	79.310	Panthera_tigris_altaica
ENSG00000158806	NPM2	100	100.000	ENSPTRG00000020045	NPM2	100	99.265	Pan_troglodytes
ENSG00000158806	NPM2	100	97.980	ENSPANG00000031080	NPM2	100	97.059	Papio_anubis
ENSG00000158806	NPM2	96	40.625	ENSPKIG00000009700	npm2b	57	43.103	Paramormyrops_kingsleyae
ENSG00000158806	NPM2	94	36.719	ENSPKIG00000007241	npm2a	84	36.719	Paramormyrops_kingsleyae
ENSG00000158806	NPM2	100	45.455	ENSPSIG00000007722	NPM2	81	47.159	Pelodiscus_sinensis
ENSG00000158806	NPM2	100	63.256	ENSPEMG00000013368	Npm2	92	64.141	Peromyscus_maniculatus_bairdii
ENSG00000158806	NPM2	100	42.424	ENSPCIG00000012716	-	59	43.750	Phascolarctos_cinereus
ENSG00000158806	NPM2	100	81.481	ENSPPYG00000018408	NPM2	100	81.944	Pongo_abelii
ENSG00000158806	NPM2	100	80.808	ENSPCOG00000018483	-	99	81.481	Propithecus_coquereli
ENSG00000158806	NPM2	92	67.150	ENSPVAG00000009848	NPM2	92	69.634	Pteropus_vampyrus
ENSG00000158806	NPM2	95	40.394	ENSPNAG00000001303	npm2b	76	41.026	Pygocentrus_nattereri
ENSG00000158806	NPM2	76	41.748	ENSPNAG00000018186	npm2a	74	40.171	Pygocentrus_nattereri
ENSG00000158806	NPM2	100	62.326	ENSRNOG00000025638	Npm2	92	62.626	Rattus_norvegicus
ENSG00000158806	NPM2	100	97.980	ENSRBIG00000029235	NPM2	100	97.059	Rhinopithecus_bieti
ENSG00000158806	NPM2	100	98.990	ENSRROG00000044119	NPM2	100	97.794	Rhinopithecus_roxellana
ENSG00000158806	NPM2	100	91.919	ENSSBOG00000025301	NPM2	99	91.852	Saimiri_boliviensis_boliviensis
ENSG00000158806	NPM2	93	46.739	ENSSHAG00000017903	-	100	46.739	Sarcophilus_harrisii
ENSG00000158806	NPM2	94	38.298	ENSSFOG00015010466	npm2b	79	38.356	Scleropages_formosus
ENSG00000158806	NPM2	78	46.753	ENSSPUG00000011509	NPM2	66	53.125	Sphenodon_punctatus
ENSG00000158806	NPM2	100	66.667	ENSSSCG00000009610	NPM2	98	67.956	Sus_scrofa
ENSG00000158806	NPM2	58	67.442	ENSTTRG00000008050	-	100	68.992	Tursiops_truncatus
ENSG00000158806	NPM2	100	71.717	ENSUAMG00000002809	NPM2	69	68.889	Ursus_americanus
ENSG00000158806	NPM2	100	70.707	ENSVVUG00000021949	-	100	66.071	Vulpes_vulpes
ENSG00000158806	NPM2	94	67.742	ENSVVUG00000007256	-	78	65.909	Vulpes_vulpes
ENSG00000158806	NPM2	84	39.759	ENSXETG00000016499	-	73	43.878	Xenopus_tropicalis
ENSG00000158806	NPM2	99	46.729	ENSXETG00000010542	npm2	69	48.438	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000789	cytoplasmic chromatin	12714744.	IDA	Component
GO:0000790	nuclear chromatin	12714744.	IDA	Component
GO:0001824	blastocyst development	12714744.	IMP	Process
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	12714744.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006338	chromatin remodeling	21873635.	IBA	Process
GO:0006338	chromatin remodeling	12714744.	IDA	Process
GO:0007096	regulation of exit from mitosis	12714744.	IMP	Process
GO:0007338	single fertilization	12714744.	IMP	Process
GO:0009994	oocyte differentiation	12714744.	IEP	Process
GO:0019899	enzyme binding	-	IEA	Function
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042393	histone binding	12581654.	TAS	Function
GO:0043085	positive regulation of catalytic activity	-	IEA	Process
GO:0045740	positive regulation of DNA replication	21873635.	IBA	Process
GO:0045836	positive regulation of meiotic nuclear division	12714744.	IMP	Process
GO:0051260	protein homooligomerization	-	IEA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.