EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25760059	Overexpression of serine/threonine-protein kinase-1 in pancreatic cancer tissue: Serine/threonine-protein kinase-1 knockdown increases the chemosensitivity of pancreatic cancer cells.	Mol Med Rep	2015 Jul	Wang Q	doi: 10.3892/mmr.2015.3434
24107632	SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways.	Cell Cycle	2013 Dec 15	Gubanova E	doi: 10.4161/cc.26660
23277562	Smg1 haploinsufficiency predisposes to tumor formation and inflammation.	Proc Natl Acad Sci U S A	2013 Jan 22	Roberts TL	doi: 10.1073/pnas.1215696110
21418860	[Effect of inhibiting the expression of hSMG-1 on chemosensitivity of human non-small cell lung cancer H1299 cells].	Zhonghua Yi Xue Za Zhi	2011 Mar 1	Xia QS	-
22247495	Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.	Clin Cancer Res	2012 Mar 1	Gubanova E	doi: 10.1158/1078-0432.CCR-11-2058

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	18850282	Silent	NA	L1746L	0.19
BLCA	chr16	18836180	Missense_Mutation	novel	L2604V	0.4
BLCA	chr16	18871406	Missense_Mutation	novel	L754V	0.23
BLCA	chr16	18838688	Missense_Mutation	novel	S2316C	0.07
BLCA	chr16	18896900	Missense_Mutation	novel	R50K	0.38
BLCA	chr16	18847937	Missense_Mutation	NA	S1907F	0.14
BLCA	chr16	18836527	Missense_Mutation	novel	S2537F	0.14
BLCA	chr16	18829746	Missense_Mutation	NA	S3048L	0.48
BLCA	chr16	18812038	Missense_Mutation	NA	A3571P	0.15
BLCA	chr16	18839735	Missense_Mutation	rs201679483	S2303C	0.07
BLCA	chr16	18845567	Silent	NA	I2027I	0.62
BLCA	chr16	18845609	Missense_Mutation	NA	L2013F	0.17
BLCA	chr16	18869906	Missense_Mutation	novel	D861Y	0.38
BLCA	chr16	18849253	Missense_Mutation	novel	G1863C	0.29
BLCA	chr16	18849254	Silent	novel	V1862V	0.29
BLCA	chr16	18838528	Intron	novel		0.35
BLCA	chr16	18836078	Silent	novel	L2638L	0.43
BLCA	chr16	18838431	Nonsense_Mutation	NA	R2374*	0.07
BLCA	chr16	18866645	Nonsense_Mutation	novel	S1109*	0.15
BLCA	chr16	18847835	Missense_Mutation	novel	N1941S	0.18
BLCA	chr16	18841711	Missense_Mutation	NA	E2184K	0.42
BLCA	chr16	18884093	Missense_Mutation	novel	E366K	0.24
BLCA	chr16	18828047	Missense_Mutation	novel	S3242F	0.31
BLCA	chr16	18884111	Missense_Mutation	novel	L360V	0.15
BLCA	chr16	18853623	Silent	rs767829543	T1576T	0.17
BLCA	chr16	18866623	Splice_Region	novel	G1116G	0.31
BLCA	chr16	18872250	Missense_Mutation	novel	H706R	0.17
BRCA	chr16	18829986	Frame_Shift_Del	NA	*R3025Dfs31**	0.4
BRCA	chr16	18835070	Missense_Mutation	NA	N2718D	0.33
BRCA	chr16	18819596	Missense_Mutation	NA	A3267D	0.17
BRCA	chr16	18809581	Frame_Shift_Ins	novel	*A3659Ffs31**	0.11
BRCA	chr16	18876296	Missense_Mutation	NA	T573S	0.23
BRCA	chr16	18853754	Nonsense_Mutation	NA	Q1533*	0.13
BRCA	chr16	18817408	Silent	rs759204419	A3319A	0.34
BRCA	chr16	18852412	Silent	NA	L1607L	0.19
BRCA	chr16	18845542	Missense_Mutation	novel	H2036Y	0.27
BRCA	chr16	18860681	Nonsense_Mutation	novel	S1264*	0.04
BRCA	chr16	18852079	Silent	rs747085951	P1680P	0.05
BRCA	chr16	18892339	Frame_Shift_Ins	NA	*Y143Ffs28**	0.2
BRCA	chr16	18858225	Missense_Mutation	NA	W1393C	0.27
BRCA	chr16	18859665	Missense_Mutation	novel	P1282S	0.05
BRCA	chr16	18868355	Splice_Site	NA	X1011_splice	0.6
BRCA	chr16	18882306	Silent	NA	V384V	0.13
BRCA	chr16	18863758	Missense_Mutation	novel	S1196L	0.14
BRCA	chr16	18828125	Nonsense_Mutation	NA	S3216*	0.28
BRCA	chr16	18838041	Silent	novel	L2462L	0.06
BRCA	chr16	18805890	3'UTR	novel		0.1
BRCA	chr16	18892348	Missense_Mutation	rs755122510	S140L	0.23
BRCA	chr16	18868294	Nonsense_Mutation	novel	R1031*	0.21
BRCA	chr16	18835124	Missense_Mutation	NA	C2700R	0.34
BRCA	chr16	18863666	Missense_Mutation	NA	D1227Y	0.57
BRCA	chr16	18829359	Missense_Mutation	rs765439624	R3177Q	0.05
BRCA	chr16	18811758	Splice_Region	novel		0.16
BRCA	chr16	18812098	Missense_Mutation	NA	Q3551E	0.26
BRCA	chr16	18834245	Missense_Mutation	NA	E2842K	0.55
BRCA	chr16	18858270	Silent	rs780190172	F1378F	0.18
BRCA	chr16	18876169	Silent	NA	L615L	0.31
BRCA	chr16	18836011	Missense_Mutation	NA	R2660Q	0.18
BRCA	chr16	18853737	Missense_Mutation	NA	E1538D	0.17
BRCA	chr16	18816483	Nonsense_Mutation	NA	S3374*	0.14
BRCA	chr16	18884119	Missense_Mutation	NA	S357C	0.2
BRCA	chr16	18839853	Missense_Mutation	novel	V2264F	0.22
CESC	chr16	18852102	Missense_Mutation	novel	L1673V	0.07
CESC	chr16	18837263	Missense_Mutation	novel	L2532M	0.39
CESC	chr16	18809168	3'UTR	novel		0.13
CESC	chr16	18829338	Missense_Mutation	NA	S3184Y	0.21
CESC	chr16	18837356	Nonsense_Mutation	novel	Q2501*	0.08
CESC	chr16	18870835	Silent	novel	L786L	0.45
CESC	chr16	18879654	Silent	novel	L453L	0.41
CESC	chr16	18830002	Missense_Mutation	novel	E3019D	0.58
CESC	chr16	18815592	Frame_Shift_Ins	novel	*F3455Vfs4**	0.13
CESC	chr16	18859578	Nonsense_Mutation	novel	Q1311*	0.14
CESC	chr16	18841689	Missense_Mutation	rs749375278	R2191Q	0.04
CESC	chr16	18834962	Missense_Mutation	NA	H2754N	0.56
CESC	chr16	18854791	Nonsense_Mutation	NA	E1450*	0.29
CESC	chr16	18829741	Missense_Mutation	NA	E3050K	0.21
CESC	chr16	18847937	Missense_Mutation	NA	S1907F	0.18
CESC	chr16	18809145	3'UTR	novel		0.27
CESC	chr16	18858169	Splice_Site	novel	X1412_splice	0.44
CESC	chr16	18869229	Missense_Mutation	rs369378228	R903H	0.26
CESC	chr16	18838666	Silent	novel	V2323V	0.14
CESC	chr16	18828058	Missense_Mutation	novel	Q3238H	0.35
CESC	chr16	18858273	Silent	novel	L1377L	0.12
CESC	chr16	18828153	Missense_Mutation	novel	L3207I	0.46
CESC	chr16	18871437	Missense_Mutation	novel	K743N	0.08
CESC	chr16	18815609	Missense_Mutation	NA	E3449K	0.3
CESC	chr16	18849305	Silent	rs375991428	L1845L	0.22
CESC	chr16	18870634	Nonsense_Mutation	NA	S823*	0.21
CESC	chr16	18809643	Missense_Mutation	NA	D3638N	0.44
CESC	chr16	18837413	Silent	NA	L2482L	0.42
CESC	chr16	18838570	Silent	NA	Y2355Y	0.32
CHOL	chr16	18853690	Missense_Mutation	novel	N1554T	0.3
CHOL	chr16	18884105	Missense_Mutation	novel	G362C	0.13
CHOL	chr16	18852118	Missense_Mutation	novel	E1667D	0.09
COAD	chr16	18838489	Intron	novel		0.35
COAD	chr16	18830018	Missense_Mutation	rs368592756	R3014Q	0.4
COAD	chr16	18836034	Silent	rs747172727	P2652P	0.37
COAD	chr16	18836047	Missense_Mutation	novel	A2648V	0.03
COAD	chr16	18842429	Missense_Mutation	NA	A2082V	0.41
COAD	chr16	18829582	Missense_Mutation	NA	G3103R	0.36
COAD	chr16	18849962	Silent	novel	T1816T	0.32
COAD	chr16	18896839	Silent	novel	R70R	0.22
COAD	chr16	18839735	Missense_Mutation	NA	S2303Y	0.38
COAD	chr16	18815181	Missense_Mutation	rs754039668	A3539T	0.28
COAD	chr16	18834992	Nonsense_Mutation	novel	E2744*	0.23
COAD	chr16	18845650	Nonsense_Mutation	NA	E2000*	0.37
COAD	chr16	18882189	Silent	novel	P423P	0.35
COAD	chr16	18849359	Missense_Mutation	novel	F1827L	0.38
COAD	chr16	18819533	Missense_Mutation	novel	L3288H	0.29
COAD	chr16	18829582	Missense_Mutation	NA	G3103R	0.15
COAD	chr16	18896817	Missense_Mutation	rs762928481	A78T	0.25
COAD	chr16	18854676	Missense_Mutation	rs753628889	T1488N	0.42
COAD	chr16	18876393	Missense_Mutation	novel	V541F	0.34
COAD	chr16	18850443	Missense_Mutation	NA	T1693S	0.39
COAD	chr16	18859670	Missense_Mutation	rs766665415	P1280L	0.26
COAD	chr16	18896817	Missense_Mutation	rs762928481	A78T	0.27
COAD	chr16	18892317	Silent	rs763134686	S150S	0.16
COAD	chr16	18833032	Silent	novel	L2900L	0.05
COAD	chr16	18847606	Missense_Mutation	novel	V1948G	0.37
COAD	chr16	18833068	Silent	rs755001924	D2888D	0.23
COAD	chr16	18809256	3'UTR	novel		0.3
COAD	chr16	18838553	Missense_Mutation	novel	K2361T	0.08
COAD	chr16	18859587	Missense_Mutation	NA	E1308K	0.18
COAD	chr16	18869285	Silent	novel	E884E	0.1
COAD	chr16	18838565	Missense_Mutation	novel	V2357A	0.05
COAD	chr16	18809408	3'UTR	novel		0.09
COAD	chr16	18811788	Silent	rs370585828	P3627P	0.33
COAD	chr16	18816402	Missense_Mutation	novel	C3401Y	0.34
COAD	chr16	18838490	Intron	novel		0.34
COAD	chr16	18830108	Missense_Mutation	novel	K2984R	0.06
COAD	chr16	18830333	Silent	rs760495007	P2943P	0.16
COAD	chr16	18854695	Missense_Mutation	rs749957363	E1482K	0.25
COAD	chr16	18870661	Missense_Mutation	rs755332588	R814Q	0.21
COAD	chr16	18834374	Missense_Mutation	NA	R2799W	0.29
COAD	chr16	18815579	In_Frame_Ins	novel	E3458_Y3459insLMF	0.07
COAD	chr16	18828132	Frame_Shift_Ins	novel	*A3214Rfs29**	0.06
COAD	chr16	18842299	Silent	rs777875498	G2125G	0.1
ESCA	chr16	18926046	5'UTR	novel		0.43
ESCA	chr16	18805780	3'UTR	novel		0.17
ESCA	chr16	18845461	Nonsense_Mutation	novel	K2063*	0.2
ESCA	chr16	18860697	Silent	novel	L1259L	0.09
ESCA	chr16	18812040	Missense_Mutation	novel	S3570L	0.14
ESCA	chr16	18926090	5'UTR	novel		0.24
ESCA	chr16	18829317	Missense_Mutation	novel	Q3191L	0.08
ESCA	chr16	18876297	Missense_Mutation	novel	T573P	0.11
ESCA	chr16	18847493	Missense_Mutation	novel	D1986N	0.13
GBM	chr16	18858288	Missense_Mutation	novel	D1372E	0.07
GBM	chr16	18863695	Frame_Shift_Del	novel	*T1217Qfs2**	0.28
GBM	chr16	18842384	Missense_Mutation	novel	P2097Q	0.41
GBM	chr16	18854872	Missense_Mutation	NA	E1423K	0.2
GBM	chr16	18868631	Silent	novel	G974G	0.22
GBM	chr16	18869901	Missense_Mutation	novel	F862L	0.21
GBM	chr16	18876282	Missense_Mutation	novel	N578D	0.46
GBM	chr16	18882200	Missense_Mutation	rs765183023	R420W	0.29
GBM	chr16	18847980	Nonsense_Mutation	NA	E1893*	0.06
GBM	chr16	18850447	Missense_Mutation	novel	Q1691H	0.27
GBM	chr16	18847822	Silent	novel	V1945V	0.45
GBM	chr16	18863811	Silent	NA	S1178S	0.28
GBM	chr16	18830226	Missense_Mutation	novel	V2979A	0.05
GBM	chr16	18842402	Missense_Mutation	NA	R2091H	0.06
HNSC	chr16	18837386	Missense_Mutation	novel	S2491C	0.14
HNSC	chr16	18839718	Missense_Mutation	novel	E2309Q	0.22
HNSC	chr16	18830361	In_Frame_Del	novel	R2931_H2934delinsS	0.17
HNSC	chr16	18853818	Missense_Mutation	novel	F1511L	0.34
HNSC	chr16	18876221	Missense_Mutation	novel	K598M	0.34
HNSC	chr16	18830338	Nonsense_Mutation	novel	Q2942*	0.4
HNSC	chr16	18837274	Missense_Mutation	novel	P2528L	0.29
HNSC	chr16	18837275	Missense_Mutation	novel	P2528S	0.29
HNSC	chr16	18854876	Silent	novel	L1421L	0.12
HNSC	chr16	18863794	Missense_Mutation	novel	N1184S	0.29
HNSC	chr16	18838191	Silent	novel	T2412T	0.15
HNSC	chr16	18829496	Frame_Shift_Del	novel	*K3131Sfs4**	0.16
HNSC	chr16	18816351	Missense_Mutation	novel	H3418R	0.51
HNSC	chr16	18871389	Silent	novel	K759K	0.19
HNSC	chr16	18926005	Missense_Mutation	rs775301161	G13S	0.13
HNSC	chr16	18845475	Frame_Shift_Del	novel	*L2055Ifs14**	0.32
HNSC	chr16	18816448	Missense_Mutation	novel	Q3386E	0.07
HNSC	chr16	18845544	Missense_Mutation	novel	P2035R	0.08
HNSC	chr16	18841636	Missense_Mutation	novel	D2209Y	0.21
HNSC	chr16	18838064	Missense_Mutation	novel	E2455Q	0.14
HNSC	chr16	18812063	Silent	novel	L3562L	0.21
HNSC	chr16	18871481	Nonsense_Mutation	novel	K729*	0.56
HNSC	chr16	18829395	Missense_Mutation	novel	S3165C	0.07
KICH	chr16	18838404	Missense_Mutation	novel	L2383M	0.17
KICH	chr16	18809416	3'UTR	rs776087359		0.41
KIRC	chr16	18896863	Missense_Mutation	NA	N62K	0.2
KIRC	chr16	18815495	Frame_Shift_Ins	novel	*E3487Tfs32**	0.04
KIRP	chr16	18845609	Frame_Shift_Del	novel	M2014*	0.62
KIRP	chr16	18830274	Missense_Mutation	NA	A2963E	0.44
KIRP	chr16	18830275	Missense_Mutation	NA	A2963T	0.43
KIRP	chr16	18829600	Missense_Mutation	NA	L3097I	0.59
KIRP	chr16	18870855	Missense_Mutation	rs781022848	A779V	0.54
KIRP	chr16	18845434	Missense_Mutation	NA	K2072E	0.52
KIRP	chr16	18850116	Missense_Mutation	NA	D1765G	0.33
KIRP	chr16	18838567	Silent	NA	N2356N	0.23
LAML	chr16	18839750	Missense_Mutation	novel	K2298R	0.06
LAML	chr16	18838628	Missense_Mutation	novel	R2336K	0.42
LAML	chr16	18841618	Missense_Mutation	NA	F2215L	0.46
LGG	chr16	18811968	Frame_Shift_Del	novel	*V3593Efs17**	0.35
LGG	chr16	18852100	In_Frame_Del	novel	L1673del	0.3
LGG	chr16	18896177	Missense_Mutation	novel	E96G	0.36
LGG	chr16	18815581	Missense_Mutation	novel	E3458V	0.03
LIHC	chr16	18838482	Intron	novel		0.17
LIHC	chr16	18850297	Silent	novel	F1741F	0.51
LIHC	chr16	18835092	Silent	NA	L2710L	0.56
LIHC	chr16	18829755	Missense_Mutation	novel	G3045V	0.33
LIHC	chr16	18842308	Silent	rs754045372	H2122H	0.29
LIHC	chr16	18876381	Missense_Mutation	NA	A545S	0.45
LIHC	chr16	18830117	Splice_Site	novel	X2982_splice	0.77
LIHC	chr16	18841656	Nonsense_Mutation	NA	S2202*	0.47
LIHC	chr16	18876360	Missense_Mutation	novel	V552M	0.21
LUAD	chr16	18838188	Silent	NA	L2413L	0.18
LUAD	chr16	18811805	Missense_Mutation	novel	G3622C	0.12
LUAD	chr16	18841775	Silent	NA	L2162L	0.32
LUAD	chr16	18833032	Silent	NA	L2900L	0.51
LUAD	chr16	18854695	Missense_Mutation	rs749957363	E1482K	0.13
LUAD	chr16	18836056	Missense_Mutation	novel	A2645V	0.27
LUAD	chr16	18868545	Missense_Mutation	novel	N1003I	0.3
LUAD	chr16	18849340	Missense_Mutation	novel	E1834K	0.06
LUAD	chr16	18896948	Missense_Mutation	NA	S34T	0.44
LUAD	chr16	18835017	Silent	NA	V2735V	0.12
LUAD	chr16	18845512	Missense_Mutation	NA	D2046Y	0.09
LUAD	chr16	18871382	Missense_Mutation	NA	K762E	0.3
LUAD	chr16	18828127	Missense_Mutation	novel	M3215I	0.33
LUAD	chr16	18884102	Missense_Mutation	novel	Q363E	0.17
LUAD	chr16	18811801	Missense_Mutation	NA	R3623L	0.31
LUAD	chr16	18872509	Missense_Mutation	novel	Y669S	0.12
LUAD	chr16	18815525	Missense_Mutation	rs760202459	M3477V	0.31
LUAD	chr16	18829757	Splice_Site	novel	X3045_splice	0.08
LUAD	chr16	18833013	Missense_Mutation	novel	L2907V	0.04
LUAD	chr16	18870806	Silent	novel	L795L	0.64
LUAD	chr16	18876162	Silent	novel	L618L	0.24
LUAD	chr16	18850021	Missense_Mutation	novel	V1797L	0.32
LUAD	chr16	18834962	Missense_Mutation	NA	H2754Y	0.26
LUAD	chr16	18879686	Missense_Mutation	novel	A443T	0.29
LUAD	chr16	18876383	Missense_Mutation	novel	V544A	0.32
LUAD	chr16	18872573	Missense_Mutation	novel	I648V	0.22
LUAD	chr16	18842243	Missense_Mutation	NA	G2144V	0.3
LUAD	chr16	18885544	Silent	novel	F315F	0.23
LUAD	chr16	18835071	Missense_Mutation	novel	I2717M	0.1
LUAD	chr16	18812040	Nonsense_Mutation	novel	S3570*	0.13
LUAD	chr16	18836149	Missense_Mutation	novel	S2614I	0.38
LUAD	chr16	18870817	Missense_Mutation	NA	D792N	0.31
LUAD	chr16	18885556	Silent	NA	F311F	0.17
LUAD	chr16	18872330	Silent	novel	I679I	0.12
LUAD	chr16	18839751	Missense_Mutation	novel	K2298E	0.27
LUAD	chr16	18836406	In_Frame_Del	novel	T2577del	0.17
LUAD	chr16	18882200	Missense_Mutation	rs765183023	R420W	0.35
LUAD	chr16	18836447	Missense_Mutation	novel	I2564V	0.26
LUAD	chr16	18869866	Missense_Mutation	NA	S874C	0.13
LUAD	chr16	18854875	Missense_Mutation	novel	M1422L	0.14
LUAD	chr16	18863689	Missense_Mutation	novel	S1219T	0.15
LUSC	chr16	18828146	Missense_Mutation	novel	I3209T	0.22
LUSC	chr16	18829741	Nonsense_Mutation	novel	E3050*	0.26
LUSC	chr16	18835012	Missense_Mutation	NA	V2737A	0.18
LUSC	chr16	18859635	Nonsense_Mutation	NA	Q1292*	0.31
LUSC	chr16	18850078	Nonsense_Mutation	novel	E1778*	0.16
LUSC	chr16	18850079	Silent	novel	V1777V	0.17
LUSC	chr16	18863659	Missense_Mutation	rs759501589	N1229S	0.12
LUSC	chr16	18850022	Silent	novel	L1796L	0.55
LUSC	chr16	18870695	Missense_Mutation	rs181581048	R803C	0.31
LUSC	chr16	18869945	In_Frame_Del	novel	S847_H848delinsN	0.5
LUSC	chr16	18882330	Silent	novel	S376S	0.2
LUSC	chr16	18845531	Missense_Mutation	NA	W2039C	0.35
LUSC	chr16	18858236	Missense_Mutation	novel	V1390L	0.36
LUSC	chr16	18882294	Silent	NA	V388V	0.28
LUSC	chr16	18833025	Silent	NA	L2903L	0.22
LUSC	chr16	18815466	Silent	novel	L3496L	0.13
LUSC	chr16	18833103	Missense_Mutation	novel	E2877K	0.65
LUSC	chr16	18819643	Silent	NA	A3251A	0.7
LUSC	chr16	18829591	Nonsense_Mutation	NA	Q3100*	0.3
LUSC	chr16	18836005	Missense_Mutation	NA	E2662G	0.65
LUSC	chr16	18859591	Silent	novel	P1306P	0.19
LUSC	chr16	18849269	Missense_Mutation	novel	L1857F	0.59
LUSC	chr16	18876123	Splice_Site	NA	X630_splice	0.36
LUSC	chr16	18890920	Missense_Mutation	rs761215949	V184A	0.29
LUSC	chr16	18849275	Silent	novel	L1855L	0.57
LUSC	chr16	18854894	Silent	novel	V1415V	0.33
LUSC	chr16	18926005	Missense_Mutation	rs775301161	G13S	0.11
LUSC	chr16	18819526	Silent	novel	L3290L	0.31
LUSC	chr16	18833007	Missense_Mutation	novel	A2909S	0.19
LUSC	chr16	18815555	Missense_Mutation	novel	Q3467E	0.08
LUSC	chr16	18836080	Missense_Mutation	NA	C2637F	0.2
LUSC	chr16	18859653	Missense_Mutation	NA	Q1286E	0.08
MESO	chr16	18838603	Silent	novel	D2344D	0.07
OV	chr16	18838359	Missense_Mutation	novel	Q2398E	0.04
OV	chr16	18817293	Missense_Mutation	novel	V3358L	0.1
OV	chr16	18871470	Missense_Mutation	novel	M732I	0.08
OV	chr16	18871472	Nonsense_Mutation	novel	M732*	0.07
OV	chr16	18847580	Missense_Mutation	novel	R1957W	0.41
OV	chr16	18839869	Silent	novel	G2258G	0.1
OV	chr16	18871457	Missense_Mutation	NA	E737K	0.37
OV	chr16	18834271	Missense_Mutation	novel	D2833V	0.38
OV	chr16	18836159	Missense_Mutation	novel	H2611Y	0.17
OV	chr16	18850278	Missense_Mutation	novel	C1748G	0.16
OV	chr16	18836039	Missense_Mutation	novel	Y2651H	0.09
OV	chr16	18835100	Missense_Mutation	novel	M2708L	0.03
OV	chr16	18863756	Frame_Shift_Del	NA	*K1189Nfs16**	0.21
OV	chr16	18869228	Frame_Shift_Del	novel	*R903Qfs25**	0.15
OV	chr16	18836159	In_Frame_Del	novel	A2602_H2611delinsD	0.36
OV	chr16	18869262	Missense_Mutation	NA	R892T	0.26
OV	chr16	18842438	Missense_Mutation	novel	Q2079L	0.08
PAAD	chr16	18812121	Missense_Mutation	rs748584956	R3543Q	0.18
PAAD	chr16	18829616	Silent	novel	R3091R	0.16
PAAD	chr16	18838461	Missense_Mutation	novel	S2364R	0.21
PAAD	chr16	18845461	Missense_Mutation	novel	K2063E	0.19
READ	chr16	18829504	Missense_Mutation	NA	E3129K	0.37
READ	chr16	18892344	Missense_Mutation	novel	M141I	0.07
READ	chr16	18858210	Silent	novel	R1398R	0.11
READ	chr16	18817427	Missense_Mutation	NA	R3313Q	0.44
READ	chr16	18847980	Nonsense_Mutation	NA	E1893*	0.39
READ	chr16	18869887	Missense_Mutation	NA	S867N	0.44
READ	chr16	18853625	Missense_Mutation	NA	T1576A	0.3
READ	chr16	18876298	Missense_Mutation	NA	M572I	0.31
SARC	chr16	18847878	Missense_Mutation	novel	Q1927E	0.19
SARC	chr16	18836072	Missense_Mutation	novel	Q2640K	0.17
SARC	chr16	18853801	Missense_Mutation	novel	A1517D	0.13
SARC	chr16	18829318	Nonsense_Mutation	novel	Q3191*	0.33
SARC	chr16	18863700	Silent	rs763786508	K1215K	0.46
SKCM	chr16	18842391	Missense_Mutation	novel	I2095V	0.41
SKCM	chr16	18845440	Missense_Mutation	novel	P2070S	0.26
SKCM	chr16	18839758	Silent	rs371252722	L2295L	0.23
SKCM	chr16	18834966	Silent	NA	F2752F	0.36
SKCM	chr16	18815614	Missense_Mutation	rs749231051	P3447L	0.27
SKCM	chr16	18815615	Missense_Mutation	novel	P3447S	0.26
SKCM	chr16	18832977	Missense_Mutation	NA	E2919K	0.4
SKCM	chr16	18859686	Missense_Mutation	NA	P1275S	0.35
SKCM	chr16	18833133	Missense_Mutation	NA	P2867S	0.4
SKCM	chr16	18819581	Missense_Mutation	novel	A3272V	0.43
SKCM	chr16	18838228	Missense_Mutation	novel	L2400S	0.31
SKCM	chr16	18828114	Missense_Mutation	NA	P3220A	0.22
SKCM	chr16	18834258	Silent	NA	P2837P	0.39
SKCM	chr16	18830334	Missense_Mutation	NA	P2943L	0.42
SKCM	chr16	18896156	Missense_Mutation	novel	S103L	0.5
SKCM	chr16	18815207	Missense_Mutation	novel	S3530L	0.67
SKCM	chr16	18834901	Missense_Mutation	novel	T2774I	0.37
SKCM	chr16	18812120	Silent	rs781441609	R3543R	0.46
SKCM	chr16	18812121	Missense_Mutation	rs748584956	R3543Q	0.45
SKCM	chr16	18839829	Missense_Mutation	rs377702809	R2272C	0.29
SKCM	chr16	18868573	Missense_Mutation	novel	M994V	0.51
SKCM	chr16	18849265	Missense_Mutation	rs756261490	P1859S	0.18
SKCM	chr16	18882289	Missense_Mutation	NA	P390L	0.17
SKCM	chr16	18845560	Missense_Mutation	rs753672435	A2030T	0.31
SKCM	chr16	18837322	Missense_Mutation	NA	L2512P	0.32
SKCM	chr16	18839830	Silent	novel	S2271S	0.41
SKCM	chr16	18854697	Missense_Mutation	novel	P1481L	0.34
SKCM	chr16	18896888	Missense_Mutation	NA	S54F	0.52
SKCM	chr16	18852147	Missense_Mutation	NA	P1658S	0.32
SKCM	chr16	18817408	Silent	rs759204419	A3319A	0.4
SKCM	chr16	18871403	Missense_Mutation	novel	P755S	0.54
STAD	chr16	18817397	Missense_Mutation	NA	D3323G	0.4
STAD	chr16	18863786	Missense_Mutation	novel	G1187R	0.24
STAD	chr16	18849243	Missense_Mutation	NA	S1866L	0.24
STAD	chr16	18838125	Silent	novel	A2434A	0.11
STAD	chr16	18853816	Missense_Mutation	NA	C1512Y	0.44
STAD	chr16	18833121	Nonsense_Mutation	NA	R2871*	0.41
STAD	chr16	18847511	Nonsense_Mutation	NA	R1980*	0.26
STAD	chr16	18830331	Missense_Mutation	NA	R2944I	0.34
STAD	chr16	18845538	Missense_Mutation	NA	E2037G	0.28
STAD	chr16	18869198	Nonsense_Mutation	NA	W913*	0.32
STAD	chr16	18870667	Missense_Mutation	NA	R812H	0.32
STAD	chr16	18836156	Silent	NA	L2612L	0.26
STAD	chr16	18885601	Silent	NA	C296C	0.12
STAD	chr16	18815498	Missense_Mutation	rs759196617	V3486I	0.25
STAD	chr16	18845456	Silent	novel	P2064P	0.36
STAD	chr16	18872511	Silent	NA	L668L	0.27
STAD	chr16	18847543	Missense_Mutation	novel	V1969G	0.25
STAD	chr16	18863774	Missense_Mutation	novel	C1191R	0.29
STAD	chr16	18833148	Missense_Mutation	rs540679816	R2862W	0.18
STAD	chr16	18842421	Missense_Mutation	NA	R2085C	0.19
STAD	chr16	18835043	Missense_Mutation	rs776873619	R2727C	0.42
STAD	chr16	18868533	Missense_Mutation	novel	S1007L	0.48
STAD	chr16	18841754	Silent	novel	F2169F	0.12
STAD	chr16	18869229	Missense_Mutation	rs369378228	R903H	0.34
STAD	chr16	18816325	Missense_Mutation	NA	H3427Y	0.25
STAD	chr16	18877227	Silent	novel	V508V	0.8
STAD	chr16	18845485	Silent	NA	L2055L	0.34
STAD	chr16	18833058	Missense_Mutation	NA	E2892Q	0.36
STAD	chr16	18847948	Silent	NA	S1903S	0.24
STAD	chr16	18852106	Silent	NA	G1671G	0.17
STAD	chr16	18836142	Silent	NA	C2616C	0.3
TGCT	chr16	18833068	Silent	rs755001924	D2888D	0.04
THCA	chr16	18849365	Silent	rs376900887	Q1825Q	0.1
THYM	chr16	18926005	Missense_Mutation	rs775301161	G13S	0.28
UCEC	chr16	18817371	Nonsense_Mutation	NA	R3332*	0.5
UCEC	chr16	18834929	Missense_Mutation	NA	A2765T	0.24
UCEC	chr16	18817428	Nonsense_Mutation	novel	R3313*	0.19
UCEC	chr16	18811955	Silent	novel	T3598T	0.17
UCEC	chr16	18828156	Missense_Mutation	NA	D3206Y	0.33
UCEC	chr16	18833120	Missense_Mutation	NA	R2871Q	0.34
UCEC	chr16	18836086	Missense_Mutation	rs372016014	R2635H	0.43
UCEC	chr16	18847510	Missense_Mutation	NA	R1980Q	0.32
UCEC	chr16	18896178	Missense_Mutation	NA	E96K	0.3
UCEC	chr16	18816345	Missense_Mutation	NA	R3420Q	0.28
UCEC	chr16	18829675	Missense_Mutation	NA	C3072G	0.3
UCEC	chr16	18830222	Missense_Mutation	NA	E2980D	0.38
UCEC	chr16	18842357	Missense_Mutation	NA	E2106G	0.29
UCEC	chr16	18808782	3'UTR	novel		0.35
UCEC	chr16	18819566	Missense_Mutation	novel	D3277A	0.37
UCEC	chr16	18836029	Missense_Mutation	novel	A2654V	0.41
UCEC	chr16	18838169	Missense_Mutation	novel	D2420N	0.31
UCEC	chr16	18859035	Missense_Mutation	novel	R1367K	0.09
UCEC	chr16	18864018	Silent	novel	P1159P	0.37
UCEC	chr16	18847843	Silent	novel	S1938S	0.06
UCEC	chr16	18828133	Missense_Mutation	NA	Q3213H	0.08
UCEC	chr16	18828107	Missense_Mutation	NA	R3222Q	0.21
UCEC	chr16	18837302	Missense_Mutation	novel	L2519I	0.09
UCEC	chr16	18839764	Silent	rs771397728	P2293P	0.33
UCEC	chr16	18809028	3'UTR	novel		0.33
UCEC	chr16	18809282	3'UTR	novel		0.45
UCEC	chr16	18819555	Missense_Mutation	novel	T3281A	0.37
UCEC	chr16	18834902	Missense_Mutation	novel	T2774A	0.29
UCEC	chr16	18835136	Missense_Mutation	novel	P2696S	0.44
UCEC	chr16	18838489	Intron	novel		0.48
UCEC	chr16	18850335	Missense_Mutation	novel	V1729F	0.13
UCEC	chr16	18854858	Silent	novel	T1427T	0.21
UCEC	chr16	18868248	Missense_Mutation	novel	V1046A	0.18
UCEC	chr16	18864005	Missense_Mutation	novel	N1164H	0.28
UCEC	chr16	18841690	Missense_Mutation	NA	R2191G	0.35
UCEC	chr16	18836098	Missense_Mutation	novel	R2631P	0.29
UCEC	chr16	18829647	Missense_Mutation	novel	P3081H	0.1
UCEC	chr16	18879667	Frame_Shift_Ins	novel	*S449Ffs2**	0.27
UCEC	chr16	18833067	Missense_Mutation	rs35952340	G2889S	0.4
UCEC	chr16	18847510	Missense_Mutation	NA	R1980Q	0.47
UCEC	chr16	18872253	Missense_Mutation	NA	K705T	0.41
UCEC	chr16	18884103	Silent	novel	G362G	0.42
UCEC	chr16	18809492	3'UTR	novel		0.45
UCEC	chr16	18817398	Missense_Mutation	novel	D3323N	0.4
UCEC	chr16	18854695	Missense_Mutation	rs749957363	E1482K	0.34
UCEC	chr16	18885616	Missense_Mutation	novel	E291D	0.42
UCEC	chr16	18817392	Missense_Mutation	rs756710808	A3325S	0.3
UCEC	chr16	18830046	Missense_Mutation	novel	V3005F	0.22
UCEC	chr16	18848027	Missense_Mutation	rs769869952	K1877T	0.44
UCEC	chr16	18850463	Missense_Mutation	novel	E1686G	0.29
UCEC	chr16	18829516	Missense_Mutation	novel	D3125N	0.35
UCEC	chr16	18870801	Missense_Mutation	novel	R797I	0.38
UCEC	chr16	18809028	3'UTR	novel		0.18
UCEC	chr16	18852170	Missense_Mutation	novel	K1650I	0.1
UCEC	chr16	18892317	Silent	rs763134686	S150S	0.24
UCEC	chr16	18847980	Nonsense_Mutation	NA	E1893*	0.2
UCEC	chr16	18812043	Missense_Mutation	NA	T3569I	0.24
UCEC	chr16	18850348	Silent	NA	S1724S	0.2
UCEC	chr16	18835105	Frame_Shift_Ins	novel	*T2706Kfs6**	0.1
UCEC	chr16	18879691	Missense_Mutation	rs751461063	T441M	0.22
UCEC	chr16	18815512	Missense_Mutation	NA	R3481Q	0.33
UCEC	chr16	18879590	Missense_Mutation	NA	C475R	0.29
UCEC	chr16	18841771	Frame_Shift_Ins	novel	*E2164Kfs21**	0.03
UCEC	chr16	18850246	Silent	rs549860139	N1758N	0.44
UCEC	chr16	18809383	3'UTR	rs535865943		0.22
UCEC	chr16	18836012	Nonsense_Mutation	NA	R2660*	0.24
UCEC	chr16	18842402	Missense_Mutation	NA	R2091H	0.16
UCEC	chr16	18868576	Missense_Mutation	NA	L993I	0.25
UCEC	chr16	18869904	Missense_Mutation	NA	D861E	0.11
UCEC	chr16	18870694	Missense_Mutation	rs778061610	R803H	0.11
UCEC	chr16	18872186	Splice_Region	rs750111303	T727T	0.18
UCEC	chr16	18830008	Frame_Shift_Del	NA	*N3012Rfs13**	0.49
UCEC	chr16	18845614	Missense_Mutation	novel	A2012S	0.23
UCEC	chr16	18892282	Missense_Mutation	novel	R162I	0.2
UCEC	chr16	18805812	3'UTR	novel		1
UCEC	chr16	18842394	Nonsense_Mutation	novel	E2094*	0.38
UCEC	chr16	18868710	Missense_Mutation	novel	R948Q	0.08
UCEC	chr16	18838080	Silent	NA	Q2449Q	0.65
UCEC	chr16	18839900	Missense_Mutation	NA	R2248H	0.24
UCEC	chr16	18890876	Missense_Mutation	NA	V199M	0.19
UCEC	chr16	18892317	Silent	rs763134686	S150S	0.41
UCEC	chr16	18868626	Missense_Mutation	novel	N976S	0.4
UCEC	chr16	18849983	Silent	rs755842672	H1809H	0.41
UCEC	chr16	18854696	Silent	rs757900422	P1481P	0.45
UCEC	chr16	18870661	Missense_Mutation	rs755332588	R814Q	0.07
UCEC	chr16	18848013	Missense_Mutation	rs755316887	I1882V	0.43
UCEC	chr16	18809635	Silent	novel	V3640V	0.08
UCEC	chr16	18829390	Missense_Mutation	novel	D3167N	0.31
UCEC	chr16	18836011	Missense_Mutation	NA	R2660Q	0.65
UCEC	chr16	18854695	Missense_Mutation	rs749957363	E1482K	0.43
UCEC	chr16	18868264	Missense_Mutation	novel	A1041T	0.09
UCEC	chr16	18869124	Missense_Mutation	novel	D938G	0.04
UCEC	chr16	18870694	Missense_Mutation	rs778061610	R803H	0.1
UCEC	chr16	18877212	Silent	novel	T513T	0.07
UCEC	chr16	18885588	Missense_Mutation	novel	L301I	0.07
UCEC	chr16	18816327	Missense_Mutation	novel	K3426T	0.51
UCEC	chr16	18870704	Missense_Mutation	novel	D800N	0.43
UCEC	chr16	18885617	Missense_Mutation	novel	E291A	0.08
UCEC	chr16	18806387	3'UTR	novel		0.36
UCEC	chr16	18829390	Missense_Mutation	novel	D3167N	0.27
UCEC	chr16	18836086	Missense_Mutation	rs372016014	R2635H	0.33
UCEC	chr16	18837389	Missense_Mutation	novel	G2490C	0.29
UCEC	chr16	18853624	Missense_Mutation	rs193087934	T1576M	0.07
UCEC	chr16	18885113	Missense_Mutation	novel	P333H	0.31
UCEC	chr16	18808937	3'UTR	novel		0.19
UCEC	chr16	18863821	Missense_Mutation	rs373020840	P1175L	0.08
UCEC	chr16	18838028	Missense_Mutation	rs376015835	V2467I	0.41
UCEC	chr16	18838193	Missense_Mutation	novel	T2412S	0.38
UCEC	chr16	18854759	Silent	novel	Q1460Q	0.45
UCEC	chr16	18872616	Silent	rs766227604	A633A	0.34
UCEC	chr16	18836098	Missense_Mutation	rs541077689	R2631H	0.2
UCEC	chr16	18829579	Missense_Mutation	NA	L3104I	0.33
UCEC	chr16	18870704	Missense_Mutation	novel	D800N	0.38
UCEC	chr16	18833053	Silent	novel	Q2893Q	0.49
UCEC	chr16	18860676	Nonsense_Mutation	novel	E1266*	0.38
UCEC	chr16	18868302	Missense_Mutation	rs780792392	T1028M	0.32
UCEC	chr16	18806184	3'UTR	novel		0.42
UCEC	chr16	18828157	Silent	novel	E3205E	0.4
UCEC	chr16	18850073	Missense_Mutation	novel	Q1779H	0.13
UCEC	chr16	18868326	Missense_Mutation	NA	R1020H	0.17
UCEC	chr16	18816464	Silent	novel	T3380T	0.31
UCEC	chr16	18830269	Missense_Mutation	NA	D2965N	0.11
UCEC	chr16	18847909	Missense_Mutation	novel	K1916N	0.53
UCEC	chr16	18852116	Missense_Mutation	novel	R1668I	0.38
UCEC	chr16	18858180	Missense_Mutation	NA	E1408D	0.44
UCEC	chr16	18870623	Missense_Mutation	novel	D827Y	0.46
UCEC	chr16	18872233	Missense_Mutation	novel	N712H	0.51
UCEC	chr16	18815512	Missense_Mutation	NA	R3481Q	0.45
UCEC	chr16	18816428	Missense_Mutation	NA	E3392D	0.24
UCEC	chr16	18815446	Missense_Mutation	novel	S3503N	0.1
UCEC	chr16	18896155	Silent	rs769135706	S103S	0.28
UCEC	chr16	18896799	Missense_Mutation	rs775797174	E84K	0.27
UCEC	chr16	18804861	3'UTR	novel		0.53
UCEC	chr16	18808966	3'UTR	novel		0.47
UCEC	chr16	18839825	Missense_Mutation	novel	R2273Q	0.55
UCEC	chr16	18847510	Missense_Mutation	NA	R1980Q	0.55
UCEC	chr16	18809426	3'UTR	novel		0.24
UCEC	chr16	18830343	Missense_Mutation	novel	L2940S	0.24
UCEC	chr16	18833053	Silent	novel	Q2893Q	0.25
UCEC	chr16	18842412	Missense_Mutation	novel	Y2088H	0.13
UCEC	chr16	18870618	Silent	novel	V828V	0.32
UCEC	chr16	18882195	Silent	rs573739105	G421G	0.34
UCEC	chr16	18834383	Missense_Mutation	NA	L2796V	0.4
UCEC	chr16	18833133	Frame_Shift_Ins	NA	*P2867Sfs20**	0.43
UCEC	chr16	18864035	Missense_Mutation	rs756418730	R1154C	0.25
UCEC	chr16	18816436	Missense_Mutation	novel	Q3390K	0.06
UCEC	chr16	18816437	Nonsense_Mutation	novel	Q3390*	0.04
UCEC	chr16	18806264	3'UTR	novel		0.21
UCEC	chr16	18808813	3'UTR	novel		0.13
UCEC	chr16	18809327	3'UTR	novel		0.21
UCEC	chr16	18830269	Missense_Mutation	NA	D2965N	0.18
UCEC	chr16	18852426	Missense_Mutation	novel	G1602E	0.12
UCEC	chr16	18872186	Splice_Region	rs750111303	T727T	0.17
UCEC	chr16	18882247	Missense_Mutation	novel	V404A	0.19
UCEC	chr16	18836366	Missense_Mutation	novel	D2591N	0.34
UCEC	chr16	18847582	Missense_Mutation	novel	R1956H	0.4
UCEC	chr16	18884127	Silent	novel	L354L	0.13
UCEC	chr16	18853829	Missense_Mutation	novel	A1508T	0.13
UCEC	chr16	18809560	3'UTR	novel		0.32
UCEC	chr16	18829349	Missense_Mutation	novel	E3180D	0.24
UCEC	chr16	18854695	Missense_Mutation	rs749957363	E1482K	0.39
UCEC	chr16	18809028	3'UTR	novel		0.41
UCEC	chr16	18812121	Missense_Mutation	rs748584956	R3543Q	0.36
UCEC	chr16	18829976	Missense_Mutation	novel	T3028N	0.56
UCEC	chr16	18836012	Nonsense_Mutation	NA	R2660*	0.26
UCEC	chr16	18838430	Missense_Mutation	novel	R2374Q	0.5
UCEC	chr16	18847512	Silent	novel	R1979R	0.55
UCEC	chr16	18896198	Missense_Mutation	novel	S89N	0.35
UCEC	chr16	18834940	Missense_Mutation	NA	S2761Y	0.19
UCEC	chr16	18811966	Missense_Mutation	novel	D3595Y	0.59
UCEC	chr16	18833120	Missense_Mutation	NA	R2871Q	0.28
UCEC	chr16	18838605	Missense_Mutation	novel	D2344Y	0.61
UCEC	chr16	18845509	Missense_Mutation	novel	A2047T	0.48
UCEC	chr16	18868558	Missense_Mutation	novel	E999K	0.05
UCEC	chr16	18868651	Missense_Mutation	novel	D968N	0.37
UCEC	chr16	18819503	Missense_Mutation	novel	Q3298P	0.3
UCEC	chr16	18808600	3'UTR	novel		0.31
UCEC	chr16	18833121	Nonsense_Mutation	NA	R2871*	0.18
UCEC	chr16	18806400	3'UTR	novel		0.56
UCEC	chr16	18808898	3'UTR	novel		0.48
UCEC	chr16	18853737	Missense_Mutation	NA	E1538D	0.05
UCEC	chr16	18806326	3'UTR	novel		0.14
UCEC	chr16	18854695	Missense_Mutation	rs749957363	E1482K	0.16
UCEC	chr16	18869967	Missense_Mutation	novel	E840D	0.14
UCEC	chr16	18876269	Missense_Mutation	novel	S582I	0.14
UCEC	chr16	18830035	Frame_Shift_Del	novel	*F3008Lfs10**	0.6
UCEC	chr16	18809142	3'UTR	novel		0.41
UCEC	chr16	18815512	Missense_Mutation	NA	R3481Q	0.36
UCEC	chr16	18841716	Missense_Mutation	rs565896040	R2182H	0.35
UCEC	chr16	18842413	Silent	novel	S2087S	0.25
UCEC	chr16	18847510	Missense_Mutation	NA	R1980Q	0.24
UCEC	chr16	18882300	Silent	novel	E386E	0.37
UCEC	chr16	18892217	Splice_Site	novel	X183_splice	0.26
UCEC	chr16	18876331	Silent	rs779835583	L561L	0.43
UCEC	chr16	18808600	3'UTR	novel		0.33
UCEC	chr16	18835082	Missense_Mutation	rs778490858	A2714T	0.41
UCEC	chr16	18816436	Missense_Mutation	novel	Q3390K	0.04
UCEC	chr16	18806145	3'UTR	rs546072820		0.32
UCEC	chr16	18890877	Silent	novel	D198D	0.13
UCEC	chr16	18859177	Missense_Mutation	novel	V1320M	0.34
UCEC	chr16	18809563	3'UTR	novel		0.03
UCEC	chr16	18835940	Missense_Mutation	novel	Y2684N	0.29
UCEC	chr16	18839765	Frame_Shift_Del	novel	*P2293Rfs38**	0.14
UCEC	chr16	18870710	Missense_Mutation	novel	C798R	0.32
UCEC	chr16	18811788	Silent	rs370585828	P3627P	0.26
UCEC	chr16	18815638	Missense_Mutation	NA	A3439V	0.46
UCEC	chr16	18829582	Missense_Mutation	NA	G3103R	0.2
UCEC	chr16	18833155	Silent	rs762052446	S2859S	0.44
UCEC	chr16	18854870	Missense_Mutation	NA	E1423D	0.47
UCEC	chr16	18845475	Missense_Mutation	NA	P2058Q	0.11
UCEC	chr16	18809258	3'UTR	novel		0.34
UCEC	chr16	18835105	Frame_Shift_Ins	novel	*T2706Kfs6**	0.08
UCEC	chr16	18854872	Missense_Mutation	NA	E1423K	0.19
UCEC	chr16	18877187	Missense_Mutation	novel	K522Q	0.39
UCEC	chr16	18815440	Missense_Mutation	novel	S3505I	0.21
UCEC	chr16	18817393	Silent	rs142078850	A3324A	0.37
UCEC	chr16	18828058	Silent	novel	Q3238Q	0.2
UCEC	chr16	18837405	Silent	novel	V2484V	0.15
UCEC	chr16	18847824	Missense_Mutation	novel	V1945I	0.18
UCEC	chr16	18866763	Nonsense_Mutation	novel	E1070*	0.23
UCEC	chr16	18868330	Missense_Mutation	novel	N1019D	0.18
UCEC	chr16	18869978	Missense_Mutation	novel	E837K	0.2
UCEC	chr16	18872184	Missense_Mutation	novel	R728M	0.19
UCEC	chr16	18876203	Missense_Mutation	novel	V604A	0.23
UCEC	chr16	18879534	Silent	novel	G493G	0.17
UCEC	chr16	18847543	In_Frame_Ins	novel	V1969delinsDSLSTI	0.05
UCEC	chr16	18819574	Silent	novel	V3274V	0.34
UCEC	chr16	18879683	Missense_Mutation	novel	N444Y	0.73
UCEC	chr16	18835066	Missense_Mutation	NA	S2719I	0.24
UCEC	chr16	18847527	Silent	rs760766974	H1974H	0.29
UCEC	chr16	18847522	Missense_Mutation	rs367950638	Y1976C	0.07
UCEC	chr16	18854764	Missense_Mutation	novel	A1459T	0.56
UCEC	chr16	18829360	Nonsense_Mutation	novel	R3177*	0.59
UCEC	chr16	18834373	Missense_Mutation	rs759512603	R2799Q	0.2
UCEC	chr16	18842430	Missense_Mutation	novel	A2082T	0.44
UCEC	chr16	18868327	Missense_Mutation	novel	R1020C	0.38
UCEC	chr16	18877133	Frame_Shift_Ins	novel	*E540Rfs27**	0.39
UCEC	chr16	18879508	Missense_Mutation	novel	N502T	0.07
UCEC	chr16	18884153	Missense_Mutation	novel	L346V	0.36
UCEC	chr16	18806210	3'UTR	novel		0.45
UCEC	chr16	18808632	3'UTR	novel		0.38
UCEC	chr16	18809282	3'UTR	novel		0.41
UCEC	chr16	18829314	Missense_Mutation	novel	R3192Q	0.45
UCEC	chr16	18838182	Missense_Mutation	novel	E2415D	0.39
UCEC	chr16	18853771	Missense_Mutation	rs201540056	T1527I	0.31
UCS	chr16	18812096	Silent	novel	Q3551Q	0.29
UVM	chr16	18809608	Missense_Mutation	novel	N3649K	0.16
UVM	chr16	18809610	Missense_Mutation	novel	N3649Y	0.17

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.0833	0.23475

Survival Analysis

Cancer	P-value	Q-value
THYM	0.022	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.0099	Kaplan-Meier Survival Analysis
PAAD	0.0095	Kaplan-Meier Survival Analysis
BLCA	0.034	Kaplan-Meier Survival Analysis
READ	0.00093	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000157106 (Gene tree)
Gene ID: 23049
Gene Symbol: SMG1
Alias: LIP|KIAA0421|ATX
Full Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 121,602 bases
Position: chr16:18,804,853-18,926,454
Accession: 30045
Summary: This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22510151	Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells.	J Med Food	2012 Jun	Yanagihara S	doi: 10.1089/jmf.2012.0040
19038236	Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	Chem Biol Interact	2009 Feb 12	Prokopczyk B	doi: 10.1016/j.cbi.2008.10.051

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000568239	SMG1-215	2978	-	-	- (aa)	-	-
ENST00000567737	SMG1-213	721	-	-	- (aa)	-	-
ENST00000446231	SMG1-202	16115	XM_005255182	ENSP00000402515	3661 (aa)	XP_005255239	Q96Q15
ENST00000565324	SMG1-211	12465	XM_011545770	ENSP00000456259	3551 (aa)	XP_011544072	J3KRA9
ENST00000563235	SMG1-207	2910	-	ENSP00000455861	853 (aa)	-	H3BQN7
ENST00000569122	SMG1-216	562	-	ENSP00000455453	62 (aa)	-	H3BPS6
ENST00000569764	SMG1-217	4187	-	-	- (aa)	-	-
ENST00000562668	SMG1-206	449	-	-	- (aa)	-	-
ENST00000568038	SMG1-214	1210	-	ENSP00000458558	321 (aa)	-	I3L144
ENST00000330588	SMG1-201	1588	-	ENSP00000481150	197 (aa)	-	A0A087WXM7
ENST00000532700	SMG1-203	1259	-	ENSP00000432825	335 (aa)	-	E9PNP6
ENST00000566328	SMG1-212	550	-	ENSP00000484278	85 (aa)	-	A0A087X1K8
ENST00000561940	SMG1-204	964	-	-	- (aa)	-	-
ENST00000565224	SMG1-210	2372	-	ENSP00000458380	607 (aa)	-	I3L0W2
ENST00000563448	SMG1-208	2016	-	-	- (aa)	-	-
ENST00000563836	SMG1-209	565	-	ENSP00000456025	56 (aa)	-	H3BR09
ENST00000561947	SMG1-205	2664	-	ENSP00000460854	551 (aa)	-	I3L400

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000157106	rs71382581	16	18917144	?	Heel bone mineral density	30048462	[0.016-0.03] unit decrease	0.023129	EFO_0009270
ENSG00000157106	rs3751745	16	18806640	T	Heel bone mineral density	30598549	[0.013-0.026] unit decrease	0.0198706	EFO_0009270
ENSG00000157106	rs71382583	16	18923402	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000157106's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000157106	SMG1	100	100.000	ENSMUSG00000030655	Smg1	100	98.507	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	21873635.	IBA	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	11544179.	IDA	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	11331269.	NAS	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	16488880.	TAS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004672	protein kinase activity	14636577.	TAS	Function
GO:0004674	protein serine/threonine kinase activity	11544179.	EXP	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	11544179.15175154.19417104.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	11331269.	NAS	Function
GO:0005515	protein binding	11544179.16452507.18256688.19417104.20371770.20864032.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	14636577.15175154.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	14636577.15175154.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006406	mRNA export from nucleus	16488880.	TAS	Process
GO:0018105	peptidyl-serine phosphorylation	11544179.15175154.	IDA	Process
GO:0018105	peptidyl-serine phosphorylation	14636577.	TAS	Process
GO:0032204	regulation of telomere maintenance	17916692.	IMP	Process
GO:0042162	telomeric DNA binding	17916692.	IDA	Function
GO:0046777	protein autophosphorylation	11331269.11544179.	IDA	Process
GO:0046854	phosphatidylinositol phosphorylation	11331269.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:2001020	regulation of response to DNA damage stimulus	15175154.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.