EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19049977	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.	J Biol Chem	2009 Feb 6	Arzoine L	doi: 10.1074/jbc.M803614200
27012210	Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway.	Biochem Biophys Res Commun	2016 Apr 22	Geng C	doi: 10.1016/j.bbrc.2016.03.067
26476538	Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.	Tumour Biol	2016 Mar	He X	doi: 10.1007/s13277-015-4255-8
26464675	Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer.	Int J Clin Exp Pathol	2015 Aug 1	Gao Y	-
25501281	Targeting prostate cancer cell metabolism: impact of hexokinase and CPT-1 enzymes.	Tumour Biol	2015 Apr	Sadeghi RN	doi: 10.1007/s13277-014-2919-4

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	69343880	Silent	NA	I39I	0.32
BLCA	chr10	69315999	5'Flank	novel		0.06
BLCA	chr10	69389250	Missense_Mutation	NA	M663I	0.15
BLCA	chr10	69377027	Silent	novel	R323R	0.09
BLCA	chr10	69386416	Missense_Mutation	novel	E645Q	0.07
BLCA	chr10	69359905	Missense_Mutation	NA	D79N	0.39
BLCA	chr10	69379923	Missense_Mutation	novel	D365N	0.41
BLCA	chr10	69382492	Missense_Mutation	NA	S424F	0.38
BLCA	chr10	69369287	Missense_Mutation	novel	M214I	0.19
BLCA	chr10	69368571	Silent	rs370998274	A177A	0.14
BLCA	chr10	69384455	Missense_Mutation	NA	E565K	0.27
BLCA	chr10	69394981	Missense_Mutation	NA	G751S	0.63
BLCA	chr10	69401174	3'UTR	novel		0.22
BLCA	chr10	69384334	Splice_Region	novel	E524E	0.68
BLCA	chr10	69386376	Missense_Mutation	novel	H631Q	0.15
BLCA	chr10	69369299	Silent	NA	G218G	0.27
BLCA	chr10	69382512	Frame_Shift_Ins	novel	R432*	0.5
BLCA	chr10	69384378	Missense_Mutation	novel	R539L	0.8
BRCA	chr10	69384819	Silent	rs749313647	C581C	0.55
BRCA	chr10	69300862	Intron	rs753241777		0.25
BRCA	chr10	69401061	Missense_Mutation	novel	E894Q	0.05
BRCA	chr10	69395095	Nonsense_Mutation	NA	Q789*	0.22
BRCA	chr10	69398646	Silent	NA	L809L	0.38
BRCA	chr10	69343851	Missense_Mutation	NA	R30W	0.12
BRCA	chr10	69369556	Silent	novel	S269S	0.39
BRCA	chr10	69315902	5'Flank	novel		0.49
BRCA	chr10	69369599	Missense_Mutation	NA	G284R	0.22
CESC	chr10	69398755	Missense_Mutation	rs146727978	R846C	0.18
CESC	chr10	69395089	Missense_Mutation	novel	L787F	0.17
CESC	chr10	69300776	Intron	novel		0.39
CESC	chr10	69382623	Missense_Mutation	rs747689299	R468W	0.37
CESC	chr10	69401109	Missense_Mutation	novel	R910W	0.08
CESC	chr10	69376978	Missense_Mutation	novel	R307Q	0.21
CESC	chr10	69300785	Intron	novel		0.22
CESC	chr10	69369336	Missense_Mutation	novel	G231S	0.42
CESC	chr10	69382701	Missense_Mutation	novel	E494K	0.37
COAD	chr10	69300827	Intron	rs753916931		0.27
COAD	chr10	69369586	Silent	NA	R279R	0.3
COAD	chr10	69384865	Missense_Mutation	novel	P597S	0.37
COAD	chr10	69398676	Silent	novel	V819V	0.07
COAD	chr10	69377025	Missense_Mutation	rs770084986	R323W	0.29
COAD	chr10	69395056	Missense_Mutation	rs1054203	L776M	0.36
COAD	chr10	69360024	Silent	rs533615871	I118I	0.24
COAD	chr10	69401110	Missense_Mutation	rs775763125	R910Q	0.18
COAD	chr10	69380023	Missense_Mutation	rs775082107	R398H	0.04
COAD	chr10	69382695	Missense_Mutation	rs373626952	R492W	0.31
COAD	chr10	69288733	5'UTR	novel		0.24
COAD	chr10	69359913	Silent	NA	I81I	0.26
COAD	chr10	69384839	Missense_Mutation	NA	Y588F	0.44
COAD	chr10	69392274	Missense_Mutation	novel	V729L	0.44
COAD	chr10	69300820	Intron	rs548563930		0.18
COAD	chr10	69315979	5'Flank	NA		0.1
COAD	chr10	69379890	Nonsense_Mutation	NA	E354*	0.26
COAD	chr10	69380004	Missense_Mutation	rs140290094	A392T	0.31
COAD	chr10	69394993	Missense_Mutation	rs762936110	R755C	0.34
ESCA	chr10	69384442	Silent	rs199870318	Y560Y	0.54
GBM	chr10	69386391	Missense_Mutation	novel	L636F	0.09
GBM	chr10	69369592	Missense_Mutation	novel	I281M	0.24
GBM	chr10	69389282	Missense_Mutation	novel	V674D	0.85
GBM	chr10	69379908	Nonsense_Mutation	novel	G360*	0.06
HNSC	chr10	69382762	Missense_Mutation	NA	S514F	0.08
HNSC	chr10	69343830	Missense_Mutation	novel	D23N	0.19
HNSC	chr10	69343887	Missense_Mutation	rs777012229	R42C	0.13
HNSC	chr10	69288673	Splice_Region	rs149940933		0.18
HNSC	chr10	69382767	Missense_Mutation	NA	V516I	0.15
KIRC	chr10	69343988	Splice_Region	NA	S75S	0.39
KIRP	chr10	69376958	Missense_Mutation	NA	M300I	0.23
KIRP	chr10	69368544	Silent	NA	L168L	0.41
KIRP	chr10	69401022	Missense_Mutation	novel	E881K	0.36
LAML	chr10	69398646	Silent	NA	L809L	0.12
LGG	chr10	69377053	Missense_Mutation	NA	G332E	0.04
LGG	chr10	69369596	Missense_Mutation	novel	R283W	0.27
LGG	chr10	69401010	Nonsense_Mutation	NA	Q877*	0.31
LGG	chr10	69377007	Missense_Mutation	rs202028638	G317S	0.45
LIHC	chr10	69377080	Missense_Mutation	NA	A341V	0.39
LIHC	chr10	69318879	5'UTR	novel		0.15
LIHC	chr10	69389206	Silent	NA	L649L	0.81
LIHC	chr10	69398610	Silent	novel	L797L	0.3
LIHC	chr10	69401207	3'UTR	novel		0.63
LUAD	chr10	69288727	5'UTR	novel		0.38
LUAD	chr10	69377084	Silent	rs567037782	I342I	0.18
LUAD	chr10	69379981	Missense_Mutation	NA	N384S	0.24
LUAD	chr10	69398695	Missense_Mutation	novel	V826L	0.14
LUAD	chr10	69398706	Missense_Mutation	NA	R829S	0.18
LUAD	chr10	69343860	Missense_Mutation	NA	D33Y	0.26
LUAD	chr10	69398701	Missense_Mutation	novel	R828W	0.55
LUAD	chr10	69343852	Missense_Mutation	rs772637781	R30Q	0.41
LUAD	chr10	69343853	Silent	novel	R30R	0.42
LUAD	chr10	69369255	Missense_Mutation	rs747711080	V204I	0.19
LUAD	chr10	69315960	5'Flank	novel		0.15
LUAD	chr10	69401108	Silent	novel	V909V	0.14
LUAD	chr10	69382613	Silent	rs192297958	A464A	0.29
LUAD	chr10	69386355	Missense_Mutation	novel	K624N	0.11
LUAD	chr10	69315896	5'Flank	novel		0.5
LUAD	chr10	69288765	Missense_Mutation	NA	E8K	0.15
LUAD	chr10	69318965	Silent	NA	L6L	0.18
LUAD	chr10	69343922	Silent	NA	R53R	0.13
LUAD	chr10	69395008	Missense_Mutation	novel	D760Y	0.1
LUSC	chr10	69315951	5'Flank	novel		0.3
LUSC	chr10	69401116	Missense_Mutation	novel	R912L	0.15
LUSC	chr10	69369596	Silent	novel	R283R	0.1
LUSC	chr10	69369311	Silent	rs759878997	Q222Q	0.69
LUSC	chr10	69369462	Missense_Mutation	novel	Y238F	0.22
LUSC	chr10	69376953	Missense_Mutation	novel	G299C	0.25
LUSC	chr10	69398616	Silent	NA	Q799Q	0.22
LUSC	chr10	69386401	Missense_Mutation	NA	A640S	0.22
LUSC	chr10	69398641	Missense_Mutation	NA	G808C	0.39
LUSC	chr10	69380045	Missense_Mutation	novel	R405S	0.3
OV	chr10	69359917	Missense_Mutation	NA	L83V	0.32
OV	chr10	69382682	Silent	rs750415580	V487V	0.35
PAAD	chr10	69360021	Silent	novel	N117N	0.14
PAAD	chr10	69369570	Missense_Mutation	novel	R274Q	0.21
PAAD	chr10	69382730	Silent	NA	T503T	0.21
PRAD	chr10	69401163	3'UTR	novel		0.44
PRAD	chr10	69379922	Silent	rs755245138	S364S	0.14
PRAD	chr10	69295635	Splice_Region	novel	A10A	0.1
PRAD	chr10	69392235	Missense_Mutation	novel	G716R	0.46
PRAD	chr10	69398803	Missense_Mutation	novel	G862R	0.4
READ	chr10	69394997	Missense_Mutation	novel	N756T	0.44
READ	chr10	69364845	Silent	novel	K146K	0.09
SARC	chr10	69392211	Missense_Mutation	novel	E708K	0.42
SKCM	chr10	69395031	Silent	rs767066673	L767L	0.29
SKCM	chr10	69316002	5'Flank	novel		0.16
SKCM	chr10	69364889	Missense_Mutation	novel	S161F	0.31
SKCM	chr10	69315913	5'Flank	novel		0.13
SKCM	chr10	69343871	Silent	NA	L36L	0.31
SKCM	chr10	69359997	Silent	NA	S109S	0.35
SKCM	chr10	69382547	Silent	NA	F442F	0.38
SKCM	chr10	69343977	Missense_Mutation	novel	P72S	0.7
SKCM	chr10	69384398	Missense_Mutation	rs753390525	R546C	0.27
SKCM	chr10	69401143	3'UTR	novel		0.25
SKCM	chr10	69382766	Silent	rs61751207	F515F	0.08
SKCM	chr10	69398708	Missense_Mutation	NA	A830V	0.35
SKCM	chr10	69369610	Silent	NA	N287N	0.38
SKCM	chr10	69343858	Missense_Mutation	NA	S32F	0.19
SKCM	chr10	69377084	Silent	rs567037782	I342I	0.42
STAD	chr10	69382767	Missense_Mutation	NA	V516I	0.14
STAD	chr10	69377049	Nonsense_Mutation	rs760487849	R331*	0.19
STAD	chr10	69398674	Missense_Mutation	rs771865870	V819I	0.3
STAD	chr10	69368627	Missense_Mutation	novel	R196Q	0.1
STAD	chr10	69384399	Missense_Mutation	rs548019222	R546H	0.69
STAD	chr10	69382536	Missense_Mutation	NA	D439N	0.15
STAD	chr10	69380057	Silent	rs367932087	T409T	0.33
STAD	chr10	69364865	Missense_Mutation	NA	T153M	0.24
STAD	chr10	69382498	Missense_Mutation	NA	R426H	0.43
STAD	chr10	69384371	Missense_Mutation	NA	N537H	0.4
STAD	chr10	69392285	Silent	NA	Y732Y	0.32
STAD	chr10	69382594	Missense_Mutation	NA	A458V	0.21
STAD	chr10	69364890	Silent	novel	S161S	0.33
STAD	chr10	69369327	Missense_Mutation	novel	L228M	0.37
STAD	chr10	69384912	Silent	rs143834023	D612D	0.45
STAD	chr10	69392280	Missense_Mutation	NA	E731K	0.31
STAD	chr10	69369235	Splice_Site	NA	X198_splice	0.28
STAD	chr10	69288761	Silent	novel	Q6Q	0.16
STAD	chr10	69398777	Missense_Mutation	rs538768945	R853H	0.1
STAD	chr10	69382758	Missense_Mutation	NA	P513S	0.3
STAD	chr10	69395054	Missense_Mutation	NA	T775M	0.19
STAD	chr10	69369552	Missense_Mutation	NA	G268E	0.08
STAD	chr10	69379903	Missense_Mutation	rs747980178	R358H	0.05
STAD	chr10	69368575	Missense_Mutation	NA	G179R	0.12
STAD	chr10	69368572	Missense_Mutation	NA	S178G	0.09
STAD	chr10	69384897	Missense_Mutation	NA	Q607H	0.37
UCEC	chr10	69377049	Nonsense_Mutation	rs760487849	R331*	0.51
UCEC	chr10	69382665	Missense_Mutation	NA	D482N	0.15
UCEC	chr10	69384424	Missense_Mutation	NA	E554D	0.3
UCEC	chr10	69389210	Missense_Mutation	novel	D650G	0.21
UCEC	chr10	69369295	Missense_Mutation	novel	C217Y	0.38
UCEC	chr10	69364816	Missense_Mutation	NA	F137V	0.33
UCEC	chr10	69379971	Missense_Mutation	NA	R381C	0.37
UCEC	chr10	69364874	Missense_Mutation	novel	F156S	0.34
UCEC	chr10	69384914	Missense_Mutation	rs554507867	A613V	0.24
UCEC	chr10	69360000	Missense_Mutation	novel	E110D	0.39
UCEC	chr10	69401239	3'UTR	novel		0.15
UCEC	chr10	69395008	Missense_Mutation	rs773954502	D760N	0.49
UCEC	chr10	69300795	Intron	novel		0.2
UCEC	chr10	69382568	Silent	rs142710265	S449S	0.52
UCEC	chr10	69392280	Missense_Mutation	NA	E731K	0.19
UCEC	chr10	69377050	Missense_Mutation	novel	R331Q	0.15
UCEC	chr10	69359905	Missense_Mutation	NA	D79N	0.15
UCEC	chr10	69384443	Missense_Mutation	rs780474391	A561T	0.39
UCEC	chr10	69359910	Silent	NA	F80F	0.31
UCEC	chr10	69343922	Silent	novel	R53R	0.36
UCEC	chr10	69343887	Missense_Mutation	rs777012229	R42C	0.5
UCEC	chr10	69369323	Silent	novel	V226V	0.1
UCEC	chr10	69359942	Missense_Mutation	novel	R91Q	0.24
UCEC	chr10	69380017	Missense_Mutation	rs771730411	R396H	0.35
UCEC	chr10	69386332	Missense_Mutation	rs760127339	I617V	0.2
UCEC	chr10	69384903	Silent	rs148999865	T609T	0.16
UCEC	chr10	69364799	Missense_Mutation	novel	A131V	0.34
UCEC	chr10	69369258	Missense_Mutation	novel	A205T	0.42
UCEC	chr10	69380070	Missense_Mutation	NA	G414R	0.41
UCEC	chr10	69382623	Missense_Mutation	rs747689299	R468W	0.34
UCEC	chr10	69401558	3'UTR	novel		0.34
UCEC	chr10	69386367	Silent	rs201425600	C628C	0.3
UCEC	chr10	69382497	Missense_Mutation	NA	R426C	0.33
UCEC	chr10	69401416	3'UTR	novel		0.45
UCEC	chr10	69364813	Missense_Mutation	novel	D136Y	0.17
UCEC	chr10	69382730	Silent	NA	T503T	0.1
UCEC	chr10	69288769	Missense_Mutation	rs528026907	S9L	0.19
UCEC	chr10	69359950	Missense_Mutation	rs760704259	R94W	0.21
UCEC	chr10	69369548	Missense_Mutation	novel	D267N	0.13
UCEC	chr10	69395079	Missense_Mutation	novel	E783D	0.24
UCEC	chr10	69401304	3'UTR	novel		0.59
UCEC	chr10	69386402	Missense_Mutation	novel	A640V	0.33
UCEC	chr10	69368560	Nonsense_Mutation	novel	R174*	0.36
UCEC	chr10	69382508	Missense_Mutation	novel	K429N	0.39
UCEC	chr10	69364810	Missense_Mutation	novel	G135R	0.68
UCEC	chr10	69401771	3'UTR	novel		0.47
UCEC	chr10	69392180	Missense_Mutation	novel	E697D	0.54
UCEC	chr10	69392304	Nonsense_Mutation	novel	Q739*	0.29
UCEC	chr10	69382569	Missense_Mutation	novel	G450S	0.33
UCEC	chr10	69360013	Missense_Mutation	novel	P115S	0.45
UCEC	chr10	69369281	Silent	NA	G212G	0.28
UCEC	chr10	69380087	Silent	rs144445980	T419T	0.21
UCEC	chr10	69364800	Silent	novel	A131A	0.43
UCEC	chr10	69389271	Silent	novel	P670P	0.08
UCEC	chr10	69392125	Missense_Mutation	novel	G679V	0.3
UCEC	chr10	69401666	3'UTR	novel		0.08
UCEC	chr10	69364897	Missense_Mutation	NA	D164Y	0.36
UCEC	chr10	69288769	Missense_Mutation	rs528026907	S9L	0.29
UCEC	chr10	69394989	Silent	rs568976769	I753I	0.46
UCEC	chr10	69288741	5'UTR	novel		0.25
UCEC	chr10	69300795	Intron	novel		0.21
UCEC	chr10	69379923	Missense_Mutation	novel	D365N	0.22
UCEC	chr10	69384414	Missense_Mutation	novel	R551K	0.18
UCEC	chr10	69384900	Missense_Mutation	NA	Q608H	0.23
UCEC	chr10	69401142	3'UTR	rs375340341		0.41
UCEC	chr10	69377008	Missense_Mutation	novel	G317D	0.43
UCEC	chr10	69359930	Missense_Mutation	NA	G87E	0.17
UCEC	chr10	69380050	Missense_Mutation	rs777108601	R407Q	0.16
UCEC	chr10	69379949	Silent	rs538951044	H373H	0.36
UCEC	chr10	69382696	Missense_Mutation	rs766293154	R492Q	0.41
UCEC	chr10	69338558	Intron	novel		0.57
UVM	chr10	69384351	Missense_Mutation	novel	A530V	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
ESCA	DEL	0.1957	0.039099
THCA	DEL	0.022	0.011063

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.003	Kaplan-Meier Survival Analysis
HNSC	0.00011	Kaplan-Meier Survival Analysis
BLCA	0.041	Kaplan-Meier Survival Analysis
LAML	0.0014	Kaplan-Meier Survival Analysis
UCEC	0.025	Kaplan-Meier Survival Analysis
GBM	0.0028	Kaplan-Meier Survival Analysis
UVM	0.0037	Kaplan-Meier Survival Analysis
OV	0.04	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000156515 (Gene tree)
Gene ID: 3098
Gene Symbol: HK1
Alias: N
Full Name: hexokinase 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 131,901 bases
Position: chr10:69,269,984-69,401,884
Accession: 4922
Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9705254	Identification of glyceraldehyde-3-phosphate dehydrogenase as a cellular protein that binds to the hepatitis B virus posttranscriptional regulatory element.	Virology	1998 Aug 15	Zang WQ	-
10964654	Identification of the NAD(+)-binding fold of glyceraldehyde-3-phosphate dehydrogenase as a novel RNA-binding domain.	Biochem Biophys Res Commun	2000 Aug 28	Nagy E	-
8722688	Testis-specific expression of mRNAs for a unique human type 1 hexokinase lacking the porin-binding domain.	Mol Reprod Dev	1996 May	Mori C	-
8420004	Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase.	Science	1993 Jan 15	Singh R	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494253	HK1-217	2848	-	-	- (aa)	-	-
ENST00000483077	HK1-214	750	-	-	- (aa)	-	-
ENST00000464803	HK1-208	567	-	ENSP00000496531	59 (aa)	-	A0A2R8Y7T9
ENST00000488644	HK1-215	593	-	-	- (aa)	-	-
ENST00000480047	HK1-212	575	-	-	- (aa)	-	-
ENST00000421088	HK1-204	707	-	ENSP00000398316	114 (aa)	-	B1AR62
ENST00000360289	HK1-203	3961	XM_011539732	ENSP00000353433	905 (aa)	XP_011538034	P19367
ENST00000643399	HK1-218	3998	-	ENSP00000494664	921 (aa)	-	P19367
ENST00000436817	HK1-205	3835	-	ENSP00000415949	921 (aa)	-	P19367
ENST00000448642	HK1-206	3868	XM_024447969	ENSP00000402103	921 (aa)	XP_024303737	P19367
ENST00000359426	HK1-202	3605	XM_005269737	ENSP00000352398	917 (aa)	XP_005269794	P19367
ENST00000479594	HK1-211	680	-	-	- (aa)	-	-
ENST00000450646	HK1-207	449	-	ENSP00000409761	30 (aa)	-	P78542
ENST00000470050	HK1-209	314	-	-	- (aa)	-	-
ENST00000483054	HK1-213	592	-	-	- (aa)	-	-
ENST00000476368	HK1-210	456	-	ENSP00000495526	29 (aa)	-	A0A2R8YEE7
ENST00000493591	HK1-216	3745	-	ENSP00000494917	92 (aa)	-	A0A2R8Y626
ENST00000298649	HK1-201	3229	-	ENSP00000298649	916 (aa)	-	P19367

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00051	Fructose and mannose metabolism	KEGG
hsa00052	Galactose metabolism	KEGG
hsa00500	Starch and sucrose metabolism	KEGG
hsa00520	Amino sugar and nucleotide sugar metabolism	KEGG
hsa00524	Neomycin, kanamycin and gentamicin biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04930	Type II diabetes mellitus	KEGG
hsa04973	Carbohydrate digestion and absorption	KEGG
hsa05230	Central carbon metabolism in cancer	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000156515	Hemoglobins	2E-11	19862010
ENSG00000156515	Hematocrit	1E-13	19862010
ENSG00000156515	Hemoglobins	1E-8	28017375
ENSG00000156515	Hemoglobins	4E-20	23222517
ENSG00000156515	hemoglobin A1c protein, human	3E-54	20858683
ENSG00000156515	hemoglobin A1c protein, human	2E-25	19096518

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000156515	rs2278745	10	69392335	C	Iris color (b* coordinate)	29109912	[0.25-0.54] unit decrease	0.394833	EFO_0003949
ENSG00000156515	rs2278745	10	69392335	C	Iris color (a* coordinate)	29109912	[0.25-0.54] unit decrease	0.395	EFO_0003949
ENSG00000156515	rs17476364	10	69334748	C	High light scatter reticulocyte percentage of red cells	27863252	[0.077-0.099] unit increase	0.08805049	EFO_0007986
ENSG00000156515	rs17476364	10	69334748	C	Reticulocyte count	27863252	[0.11-0.13] unit increase	0.1197591	EFO_0007986
ENSG00000156515	rs17476364	10	69334748	C	Mean corpuscular hemoglobin	27863252	[0.068-0.09] unit increase	0.07898236	EFO_0004527
ENSG00000156515	rs17476364	10	69334748	C	Red blood cell count	27863252	[0.072-0.094] unit increase	0.0833013	EFO_0004305
ENSG00000156515	rs17476364	10	69334748	C	Mean corpuscular volume	27863252	[0.077-0.099] unit increase	0.08811442	EFO_0004526
ENSG00000156515	rs16926246	10	69333636	?	Hemoglobin levels	28017375			EFO_0004509
ENSG00000156515	rs10159477	10	69340132	A	Red blood cell traits	23222517	[0.067-0.107] unit increase	0.087	EFO_0004509
ENSG00000156515	rs7072268	10	69340157	A	Glycated hemoglobin levels	19096518	[NR] % increase	0.05	EFO_0004541
ENSG00000156515	rs16926246	10	69333636	T	Hemoglobin	19862010	[0.08-0.14] g/dl increase	0.11	EFO_0004509
ENSG00000156515	rs16926246	10	69333636	T	Hematocrit	19862010	[0.24-0.42] % increase	0.33	EFO_0004348
ENSG00000156515	rs4745982	10	69330087	T	Glycated hemoglobin levels	28898252	[0.084-0.106] unit increase	0.0954	EFO_0004541
ENSG00000156515	rs10823343	10	69331257	A	Glycated hemoglobin levels	28898252	[0.028-0.037] unit increase	0.0325	EFO_0004541
ENSG00000156515	rs10823343	10	69331257	G	Hemoglobin A1c levels	29844224	[0.027-0.067] unit decrease	0.047	EFO_0007629
ENSG00000156515	rs11596587	10	69354232	T	Ischemic stroke (cardioembolic)	29531354	[1.14-1.31]	1.22	EFO_1001976
ENSG00000156515	rs17476364	10	69334748	C	Hematocrit	27863252	[0.14-0.16] unit increase	0.1517784	EFO_0004348
ENSG00000156515	rs17476364	10	69334748	C	Hemoglobin concentration	27863252	[0.14-0.16] unit increase	0.151392	EFO_0004509
ENSG00000156515	rs17476364	10	69334748	C	Reticulocyte fraction of red cells	27863252	[0.092-0.115] unit increase	0.1032995	EFO_0007986
ENSG00000156515	rs72805692	10	69339353	G	Immature fraction of reticulocytes	27863252	[0.027-0.048] unit increase	0.03743759	EFO_0007986
ENSG00000156515	rs17476364	10	69334748	C	Red cell distribution width	27863252	[0.027-0.049] unit increase	0.03797962	EFO_0005192
ENSG00000156515	rs17476364	10	69334748	C	High light scatter reticulocyte count	27863252	[0.09-0.112] unit increase	0.1009026	EFO_0007986
ENSG00000156515	rs16926246	10	69333636	C	Glycated hemoglobin levels	20858683	[0.08-0.10] % increase	0.09	EFO_0004541
ENSG00000156515	rs17476364	10	69334748	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000156515	rs17476364	10	69334748	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000156515	rs2305196	10	69384568	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000156515	rs17476364	10	69334748	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000156515's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000156515	HK1	99	73.982	ENSG00000159399	HK2	99	73.982	Homo_sapiens
ENSG00000156515	HK1	99	73.982	ENSMUSG00000000628	Hk2	99	73.982	Mus_musculus
ENSG00000156515	HK1	94	35.857	YGL253W	HXK2	98	35.438	Saccharomyces_cerevisiae
ENSG00000156515	HK1	99	34.447	YFR053C		97	34.447	Saccharomyces_cerevisiae
ENSG00000156515	HK1	98	33.333	YCL040W	GLK1	98	33.333	Saccharomyces_cerevisiae
ENSG00000156515	HK1	93	35.056	YDR516C		98	35.056	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001678	cellular glucose homeostasis	21873635.	IBA	Process
GO:0002741	positive regulation of cytokine secretion involved in immune response	-	IEA	Process
GO:0004340	glucokinase activity	21873635.	IBA	Function
GO:0004396	hexokinase activity	27374331.	IMP	Function
GO:0005515	protein binding	28054552.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005536	glucose binding	-	IEA	Function
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005741	mitochondrial outer membrane	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006096	glycolytic process	21873635.	IBA	Process
GO:0008865	fructokinase activity	21873635.	IBA	Function
GO:0019158	mannokinase activity	21873635.	IBA	Function
GO:0042802	identical protein binding	28054552.29568061.	IPI	Function
GO:0042834	peptidoglycan binding	27374331.	IDA	Function
GO:0045121	membrane raft	-	IEA	Component
GO:0046835	carbohydrate phosphorylation	27374331.	IMP	Process
GO:0050718	positive regulation of interleukin-1 beta secretion	-	IEA	Process
GO:0051156	glucose 6-phosphate metabolic process	-	IEA	Process
GO:0061621	canonical glycolysis	-	TAS	Process
GO:0072655	establishment of protein localization to mitochondrion	23962723.	IMP	Process
GO:0072656	maintenance of protein location in mitochondrion	23962723.	IMP	Process

EuRBPDB

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