EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19037095Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.Mol Biol Cell2009 FebLiu Zdoi: 10.1091/mbc.E08-09-0983
28157208RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.Cell Death Differ2017 AprTarcic Odoi: 10.1038/cdd.2016.126
26854224RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer.Cell Rep2016 Feb 16Tarcic Odoi: 10.1016/j.celrep.2016.01.020
22155569Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.Mol Cell Endocrinol2012 Mar 5Jskelinen Tdoi: 10.1016/j.mce.2011.11.025
27798111The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.Hum Mol Genet2016 Dec 15Dickson KAdoi: 10.1093/hmg/ddw362.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr9101540346SilentnovelL91L0.08
BLCAchr9101540525Nonsense_MutationnovelY111*0.5
BLCAchr9101540821SilentnovelF158F0.36
BRCAchr9101540316Silentrs775041387R81R0.21
BRCAchr9101540339Missense_MutationnovelS89L0.09
BRCAchr9101552732Missense_MutationNAK627R0.34
BRCAchr9101552169SilentnovelL479L0.08
BRCAchr9101550783Missense_MutationNAE424K0.12
BRCAchr9101552434Missense_MutationNAD528Y0.16
BRCAchr9101552392Missense_MutationNAR514C0.24
BRCAchr9101561144Missense_MutationNAQ855E0.31
BRCAchr9101551702Missense_MutationNAH431Y0.28
CESCchr9101552393Missense_Mutationrs201929039R514H0.36
CESCchr9101561096Missense_MutationnovelE839K0.27
CESCchr9101562339Missense_MutationnovelR949C0.26
COADchr9101546964Missense_Mutationrs753765875R298W0.2
COADchr9101546817Splice_RegionNA0.5
COADchr9101560921Missense_Mutationrs769326539R835C0.26
COADchr9101550616Missense_Mutationrs368721473R368Q0.38
COADchr9101551771Missense_MutationnovelM454V0.57
COADchr9101540834Missense_MutationNAA163T0.27
COADchr9101562340Missense_Mutationrs757082884R949H0.36
COADchr9101552563Nonsense_Mutationrs142811207R571*0.15
COADchr9101550616Missense_Mutationrs368721473R368Q0.37
COADchr9101552557Nonsense_Mutationrs535787053R569*0.28
COADchr9101547474Missense_Mutationrs761717076R350W0.13
COADchr9101554107Splice_SiteNAX673_splice0.32
COADchr9101550681Missense_Mutationrs755745298V390I0.19
COADchr9101550669Missense_MutationnovelS386P0.41
COADchr9101540505Missense_MutationNAR105C0.31
COADchr9101546931Nonsense_Mutationrs759230038R287*0.29
ESCAchr9101547451Missense_Mutationrs779556011R342H0.35
ESCAchr9101552656Nonsense_MutationnovelK602*0.2
GBMchr9101547137Missense_MutationnovelV299M0.12
GBMchr9101540315Missense_MutationNAR81Q0.24
GBMchr9101546900Nonsense_MutationnovelW276*0.41
GBMchr9101557510Nonsense_MutationnovelE766*0.19
GBMchr9101552249Missense_MutationnovelS506F0.3
HNSCchr9101552254Missense_MutationnovelL508V0.19
HNSCchr9101557512SilentnovelE766E0.86
HNSCchr9101562262Missense_MutationnovelP923L0.33
HNSCchr9101540514Missense_MutationnovelL108F0.36
HNSCchr9101552669Missense_MutationnovelS606C0.18
HNSCchr9101557594Nonsense_MutationnovelQ794*0.18
HNSCchr9101540348Missense_MutationnovelI92T0.04
KIRCchr9101554078Missense_MutationNAM664I0.38
KIRCchr9101547134Splice_Regionnovel0.24
KIRPchr9101540286Silentrs150763272E71E0.56
KIRPchr9101547432Missense_MutationnovelK336E0.39
KIRPchr9101540256Missense_MutationNAM61I0.63
LIHCchr9101561176Silentrs767788496I865I0.03
LIHCchr9101540942Missense_MutationnovelV199L0.38
LIHCchr9101540567SilentnovelK125K0.09
LIHCchr9101552525Missense_Mutationrs750558519N558S0.17
LIHCchr9101552748Missense_MutationNAE632D0.04
LIHCchr9101552748Missense_MutationNAE632D0.27
LUADchr9101554788Missense_Mutationrs778771772R705Q0.43
LUADchr9101544784Missense_MutationnovelE216Q0.38
LUADchr9101561912Splice_RegionnovelE884E0.46
LUADchr9101561223Missense_MutationNAR881P0.28
LUADchr9101557561Missense_MutationNAE783Q0.1
LUADchr9101554062Missense_MutationNAD659V0.06
LUADchr9101557521Missense_MutationNAK769N0.36
LUADchr9101546848Missense_MutationNAT259I0.22
LUADchr9101551726Frame_Shift_InsnovelQ440Sfs*140.08
LUADchr9101551761Missense_MutationnovelK450N0.26
LUADchr9101552410Silentrs191603421L520L0.07
LUADchr9101552385Splice_RegionnovelT511T0.24
LUADchr9101540976Splice_SiteNAX210_splice0.45
LUADchr9101552454Silentrs146044886A534A0.09
LUADchr9101557426Missense_MutationnovelA738S0.19
LUADchr9101540877Missense_MutationnovelR177L0.15
LUADchr9101562265Missense_MutationNAC924F0.15
LUADchr9101544880Nonsense_MutationNAQ248*0.12
LUADchr9101554767Missense_MutationNAE698V0.19
LUSCchr9101562353SilentnovelR953R0.1
LUSCchr9101562354Nonsense_MutationnovelQ954*0.1
LUSCchr9101544813Silentrs763268347L225L0.43
LUSCchr9101554029Missense_MutationNAD648V0.47
LUSCchr9101535510SilentNAG29G0.5
LUSCchr9101561948SilentNAT896T0.82
LUSCchr9101554819SilentNAQ715Q0.3
LUSCchr9101561919Missense_MutationNAS887P0.18
LUSCchr9101544774SilentnovelL212L0.68
LUSCchr9101552617Missense_MutationnovelE589K0.11
LUSCchr9101550744Missense_MutationnovelG411C0.32
LUSCchr9101562340Missense_MutationnovelR949L0.21
OVchr91015624693'UTRnovel0.23
OVchr9101544783Silentrs754351898E215E0.2
OVchr9101550607Missense_MutationNAV365G0.16
OVchr9101540314Nonsense_MutationNAR81*0.12
OVchr9101560863Missense_MutationNAN815K0.38
OVchr9101547498Missense_MutationNAT358P0.46
OVchr9101547444Nonsense_MutationnovelQ340*0.17
OVchr9101551692Missense_MutationNAE427D0.13
PAADchr9101540882Missense_MutationnovelE179K0.15
PRADchr9101551815SilentnovelQ468Q0.4
PRADchr9101552232Missense_MutationNAK500N0.06
PRADchr9101550681Missense_Mutationrs755745298V390I0.38
PRADchr9101552160Missense_MutationnovelM476I0.47
PRADchr9101561102Missense_MutationnovelA841T0.38
READchr9101552497Missense_MutationNAA549T0.26
READchr9101560807Missense_MutationNAA797T0.17
READchr9101561223Missense_Mutationrs776618752R881Q0.35
READchr9101540315Missense_MutationNAR81Q0.32
SKCMchr9101540504SilentnovelI104I0.19
SKCMchr9101540290Missense_Mutationrs200595234R73C0.22
SKCMchr9101550657Missense_MutationNAR382C0.41
SKCMchr9101546958SilentNAL296L0.41
SKCMchr9101535547Missense_MutationnovelS42T0.83
SKCMchr9101540956SilentNAS203S0.86
SKCMchr9101552707Missense_Mutationrs139776458R619W0.5
SKCMchr9101540555Silentrs757570520L121L0.33
SKCMchr9101550677SilentNAF388F0.06
SKCMchr9101544795SilentnovelQ219Q0.26
SKCMchr9101557397Missense_MutationnovelL728P0.92
SKCMchr9101557597Splice_SiteNAX794_splice0.24
SKCMchr9101550707SilentnovelL398L0.32
SKCMchr9101535514Missense_MutationNAT31A0.17
STADchr9101550712Missense_MutationNAA400V0.2
STADchr9101550735Missense_MutationnovelL408V0.16
STADchr9101562358Missense_MutationNAR955H0.17
STADchr9101535521Missense_MutationnovelE33G0.23
STADchr9101554721Missense_MutationNAD683N0.35
STADchr9101557432Missense_MutationnovelE740K0.1
STADchr9101550692SilentNAN393N0.09
STADchr9101557414Missense_MutationnovelV734I0.2
STADchr9101557403Missense_MutationnovelS730F0.17
STADchr9101540265SilentNAQ64Q0.26
STADchr9101552417Missense_MutationnovelS522F0.18
STADchr9101562262Missense_MutationnovelP923L0.13
STADchr9101546894SilentNAL274L0.13
STADchr9101540497Frame_Shift_Delrs768858191N103Tfs*870.26
STADchr9101540273Missense_MutationNAA67V0.22
UCECchr9101540357Missense_Mutationrs765010969R95Q0.34
UCECchr9101552219Missense_MutationNAR496I0.3
UCECchr9101552687Missense_MutationnovelK612T0.33
UCECchr9101562305SilentnovelC937C0.44
UCECchr91015632013'UTRnovel0.46
UCECchr9101552685Missense_MutationNAE611D0.31
UCECchr9101560839Missense_MutationnovelE807D0.09
UCECchr9101562281Missense_MutationNAK929N0.45
UCECchr9101544837Missense_MutationnovelQ233H0.29
UCECchr9101550614SilentNAL367L0.31
UCECchr9101540628Frame_Shift_InsNAG149Efs*420.39
UCECchr9101547467Missense_MutationnovelE347D0.25
UCECchr9101550658Missense_Mutationrs530650553R382H0.15
UCECchr9101540290Missense_Mutationrs200595234R73C0.14
UCECchr9101546853Missense_MutationnovelE261K0.05
UCECchr9101554815Frame_Shift_InsnovelQ715Cfs*130.08
UCECchr9101550783Missense_MutationNAE424K0.06
UCECchr9101550785Frame_Shift_InsnovelR425Lfs*80.06
UCECchr91015354045'UTRnovel0.31
UCECchr9101554805Frame_Shift_InsnovelI711Tfs*210.1
UCECchr9101540357Missense_Mutationrs765010969R95Q0.22
UCECchr9101547467Missense_MutationnovelE347D0.23
UCECchr9101561980Missense_MutationnovelE907A0.17
UCECchr91015625643'UTRnovel0.13
UCECchr9101535427Missense_MutationnovelS2P0.37
UCECchr9101540553Missense_MutationNAL121I0.43
UCECchr9101562299SilentnovelT935T0.25
UCECchr9101552557Nonsense_Mutationrs535787053R569*0.13
UCECchr9101552162Missense_MutationnovelR477H0.41
UCECchr9101544800Missense_MutationnovelL221P0.22
UCECchr9101552563Nonsense_Mutationrs142811207R571*0.31
UCECchr9101561087Splice_Regionrs7565900410.31
UCECchr91015632393'UTRnovel0.22
UCECchr9101552212Missense_MutationNAV494I0.22
UCECchr9101544885Missense_MutationnovelE249D0.43
UCECchr9101554053Missense_MutationnovelE656G0.33
UCECchr91015624333'UTRnovel0.52
UCECchr9101540302Missense_MutationnovelE77K0.47
UCECchr9101557549Nonsense_MutationNAE779*0.29
UCECchr9101561985Missense_Mutationrs772228228L909M0.2
UCECchr9101561177Missense_Mutationrs78555934V866M0.41
UCECchr91015627093'UTRnovel0.5
UCECchr9101552387Missense_MutationnovelR512H0.15
UCECchr9101552617Frame_Shift_InsnovelE589Gfs*130.05
UCECchr9101552619Frame_Shift_InsnovelR590Vfs*220.04
UCECchr9101546853Missense_MutationnovelE261K0.22
UCECchr91015631343'UTRnovel0.44
UCECchr9101540563Missense_MutationnovelR124Q0.53
UCECchr91015625013'UTRnovel0.46
UCECchr91015631803'UTRnovel0.5
UCECchr9101544864Missense_MutationnovelK242N0.1
UCECchr9101557514Missense_MutationnovelR767H0.36
UCECchr9101540563Missense_MutationnovelR124Q0.4
UCECchr9101561196Missense_MutationnovelK872T0.39
UCECchr9101552722Nonsense_MutationnovelE624*0.06
UCECchr9101540547Missense_MutationnovelD119Y0.33
UCECchr9101544820Missense_MutationNAE228K0.19
UCECchr9101550711Missense_MutationNAA400T0.27
UCECchr9101552157SilentnovelE475E0.04
UCECchr91015624853'UTRnovel0.15
UCECchr9101540314Nonsense_MutationNAR81*0.32
UCECchr9101540234Missense_MutationNAK54T0.44
UCECchr9101554805Frame_Shift_InsnovelI711Tfs*210.09
UCECchr9101540240Missense_MutationnovelR56H0.4
UCECchr9101540506Missense_Mutationrs762616554R105H0.2
UCECchr9101546878Missense_MutationnovelS269Y0.2
UCECchr9101552162Missense_MutationnovelR477H0.2
UCECchr9101552562SilentnovelE570E0.24
UCECchr9101561151Missense_MutationnovelK857T0.26
UCECchr91015626703'UTRnovel0.39
UCECchr9101540289SilentnovelL72L0.42
UCECchr9101552161Missense_Mutationrs775924339R477C0.28
UCECchr9101557549Nonsense_MutationNAE779*0.27
UCECchr9101561230Missense_MutationNAQ883H0.25
UCECchr9101562314SilentNAV940V0.14
UCECchr9101552393Missense_Mutationrs201929039R514H0.39
UCECchr9101540506Missense_Mutationrs762616554R105H0.36
UCECchr9101554090Missense_MutationnovelK668N0.29
UCECchr9101554741Missense_MutationNAK689N0.48
UCECchr9101544837Missense_MutationnovelQ233H0.39
UCECchr91015627263'UTRnovel0.25
UCSchr9101554087Silentrs147900751E667E0.31
UCSchr9101554703Missense_MutationnovelL677I0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.37250.11788
CHOLDEL0.47220.067545
LAMLDEL0.02090.24147
LIHCDEL0.26220.12467
PRADAMP0.07520.059049
THCADEL0.04010.24038
THYMDEL0.01630.022012
UCSDEL0.60710.089783

Survival Analysis
CancerP-value Q-value
ACC0.00052

Kaplan-Meier Survival Analysis

PAAD0.019

Kaplan-Meier Survival Analysis

PCPG0.048

Kaplan-Meier Survival Analysis

BLCA0.015

Kaplan-Meier Survival Analysis

LIHC0.0081

Kaplan-Meier Survival Analysis

OV0.039

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000155827 (Gene tree)
Gene ID
56254
Gene Symbol
RNF20
Alias
FLJ20382|FLJ11189|KAIA2779|BRE1A|hBRE1|BRE1
Full Name
ring finger protein 20
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
29,496 bases
Position
chr9:101,533,849-101,563,344
Accession
10062
RBP type
non-canonical RBP
Summary
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000479306RNF20-205387-ENSP0000041920199 (aa)-C9JWJ4
ENST00000389120RNF20-2023940XM_011518862ENSP00000373772975 (aa)XP_011517164Q5VTR2
ENST00000374819RNF20-201596-ENSP00000363952181 (aa)-C9JXC9
ENST00000466817RNF20-203784-ENSP00000418924145 (aa)-C9J0A5
ENST00000481046RNF20-206601--- (aa)--
ENST00000478072RNF20-204609--- (aa)--
Gene Model
Click here to download ENSG00000155827's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000155827's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000155827RNF209942.007FBgn0086694Bre15040.072Drosophila_melanogaster
ENSG00000155827RNF2010070.297ENSG00000103549RNF409966.667Homo_sapiens
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000151ubiquitin ligase complex16307923.IDAComponent
GO:0000209protein polyubiquitination19037095.IDAProcess
GO:0002039p53 binding16337599.IDAFunction
GO:0003682chromatin binding-IEAFunction
GO:0003713transcription coactivator activity16337599.IDAFunction
GO:0003730mRNA 3'-UTR binding19575011.IDAFunction
GO:0004842ubiquitin-protein transferase activity19037095.IDAFunction
GO:0004842ubiquitin-protein transferase activity16307923.IDAFunction
GO:0005515protein binding16307923.17500595.19037095.19214193.19410543.21329877.23275563.25416956.25640309.IPIFunction
GO:0005634nucleus16307923.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus19037095.IDAComponent
GO:0006355regulation of transcription, DNA-templated18832071.IMPProcess
GO:0006511ubiquitin-dependent protein catabolic process19037095.IMPProcess
GO:0007346regulation of mitotic cell cycle19575011.IMPProcess
GO:0010390histone monoubiquitination16307923.16337599.IDAProcess
GO:0016567protein ubiquitination-TASProcess
GO:0030336negative regulation of cell migration18832071.IDAProcess
GO:0031062positive regulation of histone methylation-IEAProcess
GO:0031625ubiquitin protein ligase binding16307923.IPIFunction
GO:0033503HULC complex19410543.IDAComponent
GO:0033523histone H2B ubiquitination16307923.16337599.IDAProcess
GO:0042393histone binding16337599.IDAFunction
GO:0045893positive regulation of transcription, DNA-templated16713563.IMPProcess
GO:0046872metal ion binding-IEAFunction
GO:1900364negative regulation of mRNA polyadenylation19575011.IMPProcess
GO:2001168positive regulation of histone H2B ubiquitination19575011.IMPProcess
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