EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24464223The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.Cell Death Differ2014 MayTufo Gdoi: 10.1038/cdd.2013.193
28534513Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway.Oncogene2017 Sep 28Kuo TFdoi: 10.1038/onc.2017.156

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr7149005265SilentnovelG466G0.14
BLCAchr7149006044Nonsense_MutationNAQ381*0.4
BLCAchr7149005179Missense_MutationNAS495C0.06
BLCAchr7149003948Missense_Mutationrs376262990Y595C0.19
BLCAchr7149011988Missense_MutationnovelM279I0.39
BRCAchr71490032193'UTRnovel0.81
BRCAchr7149021118Missense_MutationNAD40N0.15
BRCAchr7149021085Missense_MutationNAE51K0.23
BRCAchr7149003828Missense_MutationNAA635V0.15
BRCAchr7149003980Missense_MutationNAD584E0.12
BRCAchr7149014965Nonsense_MutationNAE185*0.15
BRCAchr7149012322Nonsense_MutationnovelY216_K218delins*0.42
CESCchr7149012266Missense_Mutationrs372023035A237T0.48
CESCchr7149015037Missense_MutationnovelV161L0.31
CESCchr71490031613'UTRnovel0.13
CESCchr7149005962Missense_Mutationrs757482634R408H0.33
CESCchr7149012260Missense_MutationnovelA239T0.44
CESCchr7149015027Missense_MutationnovelV164A0.35
CESCchr7149021076Missense_Mutationrs144700814D54H0.61
CESCchr7149005150Missense_MutationNAF505L0.2
COADchr7149003902SilentNAD610D0.37
COADchr7149008249Missense_MutationnovelF347L0.08
COADchr71490037623'UTRnovel0.54
COADchr71490032303'UTRnovel0.5
COADchr7149003951Missense_MutationnovelR594H0.17
COADchr7149011951Missense_MutationNAT292A0.33
COADchr7149019153Missense_MutationnovelA105V0.06
COADchr7149019091Missense_MutationnovelS126P0.08
COADchr7149003916Missense_MutationnovelA606S0.31
COADchr71490032263'UTRnovel0.19
ESCAchr7149005222Missense_Mutationrs369276090E481K0.11
ESCAchr71490031043'UTRnovel0.14
ESCAchr7149004151SilentnovelV527V0.15
GBMchr7149006033SilentNAA384A0.16
GBMchr7149012186SilentnovelP263P0.04
GBMchr7149014988Missense_MutationnovelE177V0.06
GBMchr7149005976SilentnovelS403S0.1
GBMchr7149014968Nonsense_MutationnovelK184*0.18
GBMchr7149019160Missense_MutationnovelK103Q0.21
GBMchr7149021027Missense_Mutationrs780622037A70V0.21
GBMchr7149003830Missense_MutationnovelH634Q0.34
HNSCchr7149005909Missense_MutationnovelD426Y0.44
HNSCchr7149020986SilentnovelL84L0.35
KIRPchr7149014935Missense_MutationnovelD195Y0.2
LGGchr7149021055Missense_MutationnovelE61K0.14
LGGchr7149003943Missense_Mutationrs749787555V597M0.3
LIHCchr71490037173'UTRnovel0.49
LIHCchr7149005964SilentNAK407K0.32
LIHCchr71490031453'UTRnovel0.43
LIHCchr7149011943Missense_MutationnovelK294N0.07
LUADchr7149004159Missense_MutationNAG525R0.7
LUADchr7149005953Missense_MutationNAR411M0.38
LUADchr7149004033Missense_MutationnovelS567C0.46
LUADchr7149005959Missense_MutationnovelY409C0.14
LUADchr7149005906Missense_MutationnovelY427N0.35
LUADchr7149019078Missense_MutationnovelS130I0.08
LUADchr7149005250SilentnovelG471G0.16
LUADchr7149005323Missense_MutationnovelE447V0.46
LUADchr7149003951Missense_Mutationrs779405344R594P0.14
LUADchr7149005246Missense_MutationNAD473Y0.17
LUADchr7149011933Missense_MutationNAE298Q0.27
LUADchr7149011941Missense_MutationNAQ295L0.24
LUSCchr71490037903'UTRnovel0.11
LUSCchr7149012266Missense_Mutationrs372023035A237T0.06
LUSCchr7149019080SilentNAA129A0.58
LUSCchr7149005171Missense_MutationNAL498V0.24
LUSCchr7149005273Missense_MutationnovelD464Y0.29
LUSCchr7149005274Missense_MutationnovelK463N0.29
LUSCchr7149005234Missense_Mutationrs774716231A477T0.05
LUSCchr7149005965Missense_MutationnovelK407M0.1
LUSCchr7149005359Missense_Mutationrs142057859R435Q0.23
MESOchr7149003960Missense_MutationNAP591L0.32
MESOchr7149012293Missense_MutationnovelP228S0.43
OVchr7149005220SilentnovelE481E0.11
OVchr7149021043Frame_Shift_InsnovelL65Ifs*50.06
OVchr7149021044Frame_Shift_InsnovelL65Wfs*120.06
OVchr7149005322SilentNAE447E0.41
OVchr7149019101SilentnovelA122A0.06
OVchr7149014919Missense_MutationnovelE200V0.22
OVchr7149019136Frame_Shift_DelnovelD110Kfs*240.12
OVchr7149014974Missense_MutationnovelL182M0.12
OVchr7149004009Missense_MutationNAQ575E0.18
PAADchr7149005260Missense_MutationnovelS468N0.2
PAADchr7149021074Silentrs374207775D54D0.17
PRADchr7149004043Silentrs145077850P563P0.27
PRADchr7149003932Silentrs374274813F600F0.09
READchr7149004066Missense_Mutationrs766521381G556R0.6
SARCchr7149003980Silentrs761901124D584D0.25
SKCMchr7149018998Nonsense_Mutationrs777967052Q157*0.34
SKCMchr7149018999SilentnovelT156T0.36
SKCMchr7149005948Missense_MutationNAP413S0.22
SKCMchr71490037203'UTRnovel0.25
SKCMchr71490037213'UTRnovel0.25
SKCMchr7149012284Missense_MutationNAP231S0.28
SKCMchr7149019017SilentnovelD150D0.2
SKCMchr7149005310SilentNAA451A0.61
SKCMchr7149005328Silentrs771404997F445F0.26
SKCMchr7149012216SilentnovelP253P0.2
SKCMchr7149012217Missense_MutationNAP253L0.2
SKCMchr7149003992Silentrs201327269I580I0.15
SKCMchr7149004169SilentNAK521K0.35
SKCMchr7149012284Missense_MutationNAP231S0.31
SKCMchr7149003917Silentrs142824594F605F0.17
SKCMchr7149004043Silentrs145077850P563P0.31
SKCMchr7149005972Missense_Mutationrs150817731D405N0.27
SKCMchr7149015015Missense_MutationNAS168F0.1
SKCMchr7149005228SilentnovelL479L0.2
SKCMchr7149005229SilentnovelI478I0.2
SKCMchr7149012281Silentrs368013782L232L0.18
STADchr7149012308Missense_MutationNAL223F0.12
STADchr7149006034Missense_MutationnovelA384V0.07
STADchr7149004174Missense_Mutationrs748968203P520S0.43
STADchr7149019198Splice_SitenovelX90_splice0.13
STADchr7149005902Missense_MutationNAR428T0.3
STADchr7149003965Silentrs370731622D589D0.33
STADchr71490037333'UTRrs5434700740.11
STADchr7149004097Silentrs768420155D545D0.13
UCECchr7149003967Missense_Mutationrs374110175D589N0.4
UCECchr7149005286SilentnovelA459A0.33
UCECchr7149012282SilentnovelP231P0.25
UCECchr7149011847Splice_Regionrs150481375A326A0.4
UCECchr7149012203Missense_MutationnovelF258V0.49
UCECchr7149003956Silentrs534564108S592S0.36
UCECchr7149004169Missense_MutationnovelK521N0.07
UCECchr7149008201Missense_MutationNAF363L0.23
UCECchr7149012299Missense_Mutationrs757583934R226C0.36
UCECchr7149011918Missense_MutationnovelG303R0.29
UCECchr7149012259Missense_MutationnovelA239V0.08
UCECchr7149005223Silentrs768937980D480D0.45
UCECchr7149008182Missense_MutationnovelR370W0.38
UCECchr7149003965Silentrs370731622D589D0.11
UCECchr7149012308Missense_MutationnovelL223I0.53
UCECchr7149004120Missense_Mutationrs151183604I538V0.43
UCECchr7149012345Missense_MutationnovelK210N0.17
UCECchr7149021126Missense_MutationNAA37V0.38
UCECchr71490031963'UTRnovel0.32
UCECchr71490037383'UTRnovel0.73
UCECchr7149019044SilentNAK141K0.37
UCECchr71490037863'UTRnovel0.14
UCECchr71490031233'UTRnovel0.12
UCECchr7149012298Missense_Mutationrs371907961R226H0.05
UCECchr7149021073Missense_Mutationrs767502349D55N0.41
UCECchr7149012266Missense_Mutationrs372023035A237T0.31
UCECchr7149008240SilentnovelV350V0.31
UCECchr7149014999SilentNAT173T0.49
UCECchr7149006034Missense_MutationnovelA384V0.45
UCECchr7149021006Missense_MutationnovelA77V0.39
UCECchr7149005238SilentnovelN475N0.27
UCECchr7149003896Missense_MutationnovelK612N0.43
UCECchr7149004075Missense_MutationnovelP553S0.36
UCSchr7149005146Missense_MutationnovelK506R0.26
UCSchr7149021047SilentnovelG63G0.23

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.06670.12261
CESCDEL0.17970.0016147
DLBCDEL0.1250.03486
HNSCDEL0.19351.1399e-22
KIRCAMP0.28980.075418
LAMLDEL0.13093.4101e-05
LGGAMP0.31381.5525e-07
LIHCDEL0.08380.24831
OVAMP0.48531.5763e-13
PAADDEL0.06520.049388
TGCTDEL0.07330.11738
THCADEL00.27619
UCECDEL0.09650.0001859
UCSDEL0.33930.10142

Survival Analysis
CancerP-value Q-value
KIRC0.0039

Kaplan-Meier Survival Analysis

SARC0.0045

Kaplan-Meier Survival Analysis

ACC0.0031

Kaplan-Meier Survival Analysis

KIRP0.00045

Kaplan-Meier Survival Analysis

PAAD0.0037

Kaplan-Meier Survival Analysis

CESC0.0053

Kaplan-Meier Survival Analysis

LAML0.0072

Kaplan-Meier Survival Analysis

UCEC0.022

Kaplan-Meier Survival Analysis

GBM0.00011

Kaplan-Meier Survival Analysis

UVM0.0012

Kaplan-Meier Survival Analysis

OV0.002

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000155660 (Gene tree)
Gene ID
9601
Gene Symbol
PDIA4
Alias
ERP70|ERP72
Full Name
protein disulfide isomerase family A member 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
25,640 bases
Position
chr7:149,003,051-149,028,690
Accession
30167
RBP type
non-canonical RBP
Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000466592PDIA4-203632--- (aa)--
ENST00000286091PDIA4-2012903XM_006716185ENSP00000286091645 (aa)XP_006716248P13667
ENST00000413966PDIA4-202550-ENSP00000408628163 (aa)-C9JMN9
Gene Model
Click here to download ENSG00000155660's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
hsa04918Thyroid hormone synthesisKEGG
hsa05110Vibrio cholerae infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000155660Bone Density8E-628181694
ENSG00000155660Colorectal Neoplasms1E-626621817
ENSG00000155660Endometrial Neoplasms1E-626621817
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000155660rs64649297149020375APediatric bone mineral content (hip)28181694[0.1-0.26] unit increase0.179616EFO_0007621
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000155660's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000155660PDIA49190.925ENSMUSG00000025823Pdia410087.752Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0003756protein disulfide isomerase activity21873635.IBAFunction
GO:0003756protein disulfide isomerase activity-ISSFunction
GO:0005515protein binding22190034.22665516.30021884.IPIFunction
GO:0005615extracellular space19995400.IDAComponent
GO:0005783endoplasmic reticulum21873635.IBAComponent
GO:0005788endoplasmic reticulum lumen-IEAComponent
GO:0006457protein folding21873635.IBAProcess
GO:0009306protein secretion2295602.TASProcess
GO:0009986cell surface21873635.IBAComponent
GO:0009986cell surface19995400.IDAComponent
GO:0015037peptide disulfide oxidoreductase activity16677074.IDAFunction
GO:0034976response to endoplasmic reticulum stress21873635.IBAProcess
GO:0042470melanosome-IEAComponent
GO:0045454cell redox homeostasis-IEAProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0061077chaperone-mediated protein folding-ISSProcess
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