EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr7	55842974	Missense_Mutation	novel	D176Y	0.04
BLCA	chr7	55834531	Missense_Mutation	novel	Q205R	0.19
BLCA	chr7	55844623	Missense_Mutation	novel	L91F	0.53	MMR_HSR1
BLCA	chr7	55805341	Nonsense_Mutation	NA	Q346*	0.09
BLCA	chr7	55796043	Missense_Mutation	novel	R390M	0.35
BLCA	chr7	55846549	Missense_Mutation	rs201042996	R48Q	0.07
BLCA	chr7	55795857	3'UTR	novel		0.34
BLCA	chr7	55844579	Silent	novel	L105L	0.09
BLCA	chr7	55795984	Nonsense_Mutation	novel	K410*	0.15
BLCA	chr7	55807195	Missense_Mutation	novel	E294V	0.44
BLCA	chr7	55795861	3'UTR	novel		0.13
BLCA	chr7	55805272	Missense_Mutation	novel	E369K	0.24
BRCA	chr7	55843091	Missense_Mutation	NA	E137Q	0.16	MMR_HSR1
BRCA	chr7	55861961	Missense_Mutation	NA	I12M	0.86
BRCA	chr7	55846582	Missense_Mutation	NA	C37Y	0.38
BRCA	chr7	55844547	Missense_Mutation	NA	G116D	0.3	MMR_HSR1
BRCA	chr7	55846563	Silent	rs369713476	V43V	0.21
CESC	chr7	55796021	Missense_Mutation	NA	K397N	0.12
CESC	chr7	55834440	Silent	NA	A235A	0.21
CESC	chr7	55861954	Missense_Mutation	NA	D15N	0.24
CESC	chr7	55819163	Missense_Mutation	novel	V261I	0.43
CESC	chr7	55795906	3'UTR	novel		0.06
CESC	chr7	55807250	Missense_Mutation	rs78957351	E276K	0.42
COAD	chr7	55807125	Silent	novel	G317G	0.21
COAD	chr7	55819162	Missense_Mutation	novel	V261A	0.29
COAD	chr7	55846619	Missense_Mutation	NA	R25C	0.26
COAD	chr7	55834528	Missense_Mutation	rs761205837	T206M	0.11
COAD	chr7	55843030	Missense_Mutation	rs377272369	R157H	0.11	MMR_HSR1
ESCA	chr7	55819187	Missense_Mutation	NA	E253K	0.41
GBM	chr7	55843116	Missense_Mutation	novel	I128M	0.09	MMR_HSR1
GBM	chr7	55844666	Silent	novel	N76N	0.33
GBM	chr7	55796077	Missense_Mutation	rs748436093	E379K	0.28
GBM	chr7	55805342	Silent	novel	C345C	0.31
GBM	chr7	55795906	3'UTR	novel		0.15
GBM	chr7	55807095	Silent	NA	P327P	0.33
HNSC	chr7	55846576	Missense_Mutation	novel	P39H	0.34
HNSC	chr7	55807243	Missense_Mutation	novel	H278R	0.55
HNSC	chr7	55795919	Silent	NA	K431K	0.11
HNSC	chr7	55807176	Silent	novel	T300T	0.25
KIRC	chr7	55819153	Missense_Mutation	rs756494333	R264H	0.72
LGG	chr7	55834527	Silent	rs775456195	T206T	0.22
LGG	chr7	55843088	Missense_Mutation	NA	A138T	0.41	MMR_HSR1
LGG	chr7	55846619	Missense_Mutation	NA	R25C	0.34
LUAD	chr7	55834442	Missense_Mutation	NA	A235P	0.59
LUAD	chr7	55844542	Missense_Mutation	novel	Q118E	0.08	MMR_HSR1
LUAD	chr7	55834474	Missense_Mutation	novel	Q224R	0.46
LUAD	chr7	55834475	Missense_Mutation	novel	Q224K	0.46
LUAD	chr7	55795811	3'UTR	novel		0.36
LUAD	chr7	55795855	3'UTR	novel		0.2
LUAD	chr7	55796085	Missense_Mutation	NA	D376V	0.67
LUAD	chr7	55846637	Missense_Mutation	novel	Q19K	0.2
LUAD	chr7	55844718	Missense_Mutation	NA	G59V	0.26	MMR_HSR1
LUAD	chr7	55805266	Missense_Mutation	novel	E371K	0.07
LUAD	chr7	55807164	Missense_Mutation	NA	H304Q	0.22
LUAD	chr7	55834493	Missense_Mutation	novel	N218H	0.12
LUAD	chr7	55795938	Missense_Mutation	novel	K425M	0.21
LUAD	chr7	55846619	Missense_Mutation	NA	R25S	0.34
LUAD	chr7	55795927	Missense_Mutation	NA	H429Y	0.15
LUAD	chr7	55807228	Missense_Mutation	NA	K283M	0.51
LUAD	chr7	55846522	Missense_Mutation	novel	C57F	0.25	MMR_HSR1
LUAD	chr7	55842945	Silent	NA	S185S	0.5
LUAD	chr7	55795888	3'UTR	novel		0.1
LUSC	chr7	55796048	Missense_Mutation	NA	E388D	0.77
LUSC	chr7	55844584	Missense_Mutation	novel	Q104K	0.31	MMR_HSR1
LUSC	chr7	55795958	Silent	novel	T418T	0.19
LUSC	chr7	55807118	Missense_Mutation	novel	D320H	0.06
LUSC	chr7	55844634	Nonsense_Mutation	novel	S87*	0.7	MMR_HSR1
LUSC	chr7	55795851	3'UTR	novel		0.27
LUSC	chr7	55805257	Splice_Site	NA	X373_splice	0.25
LUSC	chr7	55846517	Missense_Mutation	NA	G59R	0.19	MMR_HSR1
LUSC	chr7	55846606	Missense_Mutation	novel	T29K	0.34
LUSC	chr7	55843097	Missense_Mutation	novel	Q135K	0.47	MMR_HSR1
LUSC	chr7	55807126	Missense_Mutation	NA	G317V	0.37
LUSC	chr7	55807127	Missense_Mutation	NA	G317C	0.36
LUSC	chr7	55846605	Silent	novel	T29T	0.4
LUSC	chr7	55843053	Silent	NA	S149S	0.39
LUSC	chr7	55844579	Missense_Mutation	NA	L105F	0.68	MMR_HSR1
LUSC	chr7	55834465	Missense_Mutation	novel	T227K	0.38
OV	chr7	55796068	Missense_Mutation	novel	K382Q	0.21
OV	chr7	55795962	Missense_Mutation	NA	Q417P	0.4
PRAD	chr7	55861992	Missense_Mutation	novel	A2V	0.18
READ	chr7	55844696	Silent	rs758771918	S66S	0.23
READ	chr7	55844521	Splice_Site	NA	X122_splice	0.19
READ	chr7	55795767	3'UTR	novel		0.53
READ	chr7	55796078	Silent	rs769797651	F378F	0.37
READ	chr7	55807194	Missense_Mutation	NA	E294D	0.42
READ	chr7	55807211	Missense_Mutation	NA	L289I	0.33
READ	chr7	55843058	Missense_Mutation	rs147445514	R148C	0.21	MMR_HSR1
SARC	chr7	55843033	Missense_Mutation	NA	S156Y	0.44	MMR_HSR1
SKCM	chr7	55795872	3'UTR	rs186958370		0.62
SKCM	chr7	55807250	Missense_Mutation	rs78957351	E276K	0.37
SKCM	chr7	55807233	Silent	rs763743031	F281F	0.3
SKCM	chr7	55846605	Silent	rs200755602	T29T	0.7
SKCM	chr7	55795790	3'UTR	novel		0.24
SKCM	chr7	55796078	Silent	rs769797651	F378F	0.33
SKCM	chr7	55805347	Nonsense_Mutation	NA	Q344*	0.3
SKCM	chr7	55844704	Missense_Mutation	NA	G64R	0.88	MMR_HSR1
SKCM	chr7	55795919	Silent	NA	K431K	0.31
SKCM	chr7	55805293	Missense_Mutation	NA	E362K	0.49
SKCM	chr7	55795851	3'UTR	novel		0.26
SKCM	chr7	55796078	Silent	rs769797651	F378F	0.35
SKCM	chr7	55807223	Silent	NA	R285R	0.32
SKCM	chr7	55795980	Missense_Mutation	NA	A411G	0.27
SKCM	chr7	55843103	Missense_Mutation	NA	D133N	0.28	MMR_HSR1
SKCM	chr7	55844703	Missense_Mutation	NA	G64E	0.24	MMR_HSR1
SKCM	chr7	55805287	Missense_Mutation	NA	E364K	0.42
SKCM	chr7	55796036	Silent	rs764910450	L392L	0.26
SKCM	chr7	55795789	3'UTR	novel		0.23
SKCM	chr7	55805258	Splice_Region	NA	E373E	0.1
SKCM	chr7	55846619	Missense_Mutation	NA	R25C	0.17
SKCM	chr7	55807126	Missense_Mutation	NA	G317D	0.09
SKCM	chr7	55796063	Missense_Mutation	NA	M383I	0.7
SKCM	chr7	55844659	Missense_Mutation	NA	D79N	0.6	MMR_HSR1
SKCM	chr7	55795972	Missense_Mutation	rs748203186	E414K	0.15
SKCM	chr7	55843008	Silent	NA	F164F	0.3
SKCM	chr7	55795919	Silent	NA	K431K	0.16
SKCM	chr7	55846543	Missense_Mutation	novel	G50E	0.38
STAD	chr7	55846619	Missense_Mutation	NA	R25C	0.2
STAD	chr7	55844697	Missense_Mutation	NA	S66L	0.34	MMR_HSR1
STAD	chr7	55807177	Frame_Shift_Ins	novel	*T300Nfs7**	0.39
STAD	chr7	55807178	Frame_Shift_Del	rs768200923	*T300Pfs53**	0.27
STAD	chr7	55843028	Missense_Mutation	rs778731243	V158I	0.42	MMR_HSR1
STAD	chr7	55834489	Missense_Mutation	rs149607538	G219D	0.28
STAD	chr7	55844587	Missense_Mutation	rs370499447	V103I	0.29	MMR_HSR1
STAD	chr7	55846618	Missense_Mutation	rs754503788	R25H	0.26
UCEC	chr7	55807220	Missense_Mutation	novel	D286N	0.12
UCEC	chr7	55795764	3'UTR	novel		0.42
UCEC	chr7	55843033	Missense_Mutation	NA	S156Y	0.36	MMR_HSR1
UCEC	chr7	55844567	Silent	novel	V109V	0.07
UCEC	chr7	55842953	Missense_Mutation	novel	L183I	0.04
UCEC	chr7	55844659	Missense_Mutation	novel	D79Y	0.36	MMR_HSR1
UCEC	chr7	55805315	Missense_Mutation	novel	Q354H	0.3
UCEC	chr7	55846549	Missense_Mutation	rs201042996	R48Q	0.4
UCEC	chr7	55819154	Missense_Mutation	rs778117180	R264S	0.34
UCEC	chr7	55819190	Missense_Mutation	NA	D252Y	0.12
UCEC	chr7	55834556	Missense_Mutation	novel	D197Y	0.04
UCEC	chr7	55843028	Missense_Mutation	rs778731243	V158I	0.22	MMR_HSR1
UCEC	chr7	55795841	3'UTR	novel		0.17
UCEC	chr7	55834440	Silent	NA	A235A	0.3
UCEC	chr7	55807104	Frame_Shift_Del	NA	*N324Kfs29**	0.12
UCEC	chr7	55834504	Missense_Mutation	novel	E214A	0.38
UCEC	chr7	55795945	Missense_Mutation	rs375725275	D423N	0.33
UCEC	chr7	55796078	Silent	rs769797651	F378F	0.55
UCEC	chr7	55795923	Missense_Mutation	rs777286266	R430H	0.25
UCEC	chr7	55819154	Missense_Mutation	rs778117180	R264C	0.43
UCEC	chr7	55807118	Missense_Mutation	novel	D320Y	0.44
UCEC	chr7	55842979	Missense_Mutation	novel	S174F	0.36
UCEC	chr7	55805383	Nonsense_Mutation	NA	E332*	0.37
UCEC	chr7	55819221	Splice_Region	rs372370181	G241G	0.26
UCEC	chr7	55819204	Missense_Mutation	novel	V247A	0.25
UCEC	chr7	55807233	Silent	rs763743031	F281F	0.32
UCEC	chr7	55796075	Missense_Mutation	novel	E379D	0.26
UCEC	chr7	55834550	Missense_Mutation	novel	I199L	0.28
UCEC	chr7	55843071	Silent	novel	E143E	0.31
UCEC	chr7	55795778	3'UTR	novel		0.4
UCEC	chr7	55796078	Silent	rs769797651	F378F	0.14
UCEC	chr7	55807241	Missense_Mutation	rs761901611	C279R	0.37
UCEC	chr7	55795999	Missense_Mutation	novel	D405N	0.31
UCEC	chr7	55834530	Silent	novel	Q205Q	0.22
UCEC	chr7	55796036	Silent	rs764910450	L392L	0.44
UCEC	chr7	55805375	Silent	novel	F334F	0.22
UCEC	chr7	55843088	Missense_Mutation	NA	A138T	0.4	MMR_HSR1
UCEC	chr7	55807233	Silent	rs763743031	F281F	0.24
UCEC	chr7	55805301	Missense_Mutation	rs372753552	R359Q	0.18
UCEC	chr7	55807232	Missense_Mutation	rs375026754	V282I	0.11
UCEC	chr7	55843099	Missense_Mutation	rs761426907	A134V	0.4	MMR_HSR1
UCEC	chr7	55844523	Missense_Mutation	novel	S124I	0.27	MMR_HSR1
UCS	chr7	55795906	3'UTR	rs373430126		0.31
UCS	chr7	55805391	Splice_Site	novel	X329_splice	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
LAML	0.031	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000154997 (Gene tree)
Gene ID: 346288
Gene Symbol: SEPT14
Alias: FLJ44060
Full Name: septin 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 69,246 bases
Position: chr7:55,793,544-55,862,789
Accession: 33280
RBP type: canonical RBP
Summary: SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions (Peterson et al., 2007 [PubMed 17922164]).[supplied by OMIM, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000373627	MMR_HSR1	PF01926.23	0.00012	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29133115	Structural features of the interaction of the 3'-untranslated region of mRNA containing exosomal RNA-specific motifs with YB-1, a potential mediator of mRNA sorting.	Biochimie	2018 Jan	Yanshina DD	doi: 10.1016/j.biochi.2017.11.007

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000477628	SEPT14-202	560	-	-	- (aa)	-	-
ENST00000388975	SEPT14-201	3785	XM_011515373	ENSP00000373627	432 (aa)	XP_011513675	Q6ZU15

Gene Model

Click here to download ENSG00000154997's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000154997	Parathyroid Hormone	9.5020000E-005	-
ENSG00000154997	Parathyroid Hormone	2.6730000E-005	-
ENSG00000154997	Age-Related Hearing Impairment 1	8E-6	24939585

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000154997	rs7786410	7	55854630	?	Age-related hearing impairment	24939585	[NR] unit decrease	0.1548	EFO_0005782

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000154997's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000154997	SEPT14	100	81.713	ENSAMEG00000016173	SEPT14	100	81.713	Ailuropoda_melanoleuca
ENSG00000154997	SEPT14	100	83.565	ENSANAG00000036051	SEPT14	100	83.565	Aotus_nancymaae
ENSG00000154997	SEPT14	100	78.704	ENSBTAG00000009327	SEPT14	100	78.704	Bos_taurus
ENSG00000154997	SEPT14	96	91.063	ENSCJAG00000021262	SEPT14	100	91.063	Callithrix_jacchus
ENSG00000154997	SEPT14	86	83.914	ENSCAFG00000006087	-	95	83.914	Canis_familiaris
ENSG00000154997	SEPT14	96	83.092	ENSCAFG00020020299	SEPT14	97	83.092	Canis_lupus_dingo
ENSG00000154997	SEPT14	100	85.185	ENSTSYG00000002007	SEPT14	100	85.185	Carlito_syrichta
ENSG00000154997	SEPT14	95	76.829	ENSCAPG00000000080	SEPT14	97	77.317	Cavia_aperea
ENSG00000154997	SEPT14	81	82.906	ENSCPOG00000009996	SEPT14	99	82.906	Cavia_porcellus
ENSG00000154997	SEPT14	100	93.519	ENSCCAG00000031387	SEPT14	100	93.519	Cebus_capucinus
ENSG00000154997	SEPT14	100	79.167	ENSCLAG00000005493	SEPT14	100	79.167	Chinchilla_lanigera
ENSG00000154997	SEPT14	89	91.123	ENSCSAG00000016099	SEPT14	100	91.123	Chlorocebus_sabaeus
ENSG00000154997	SEPT14	95	77.317	ENSCGRG00001018571	Sept14	97	77.317	Cricetulus_griseus_chok1gshd
ENSG00000154997	SEPT14	100	75.694	ENSCGRG00000005414	Sept14	100	75.694	Cricetulus_griseus_crigri
ENSG00000154997	SEPT14	94	79.064	ENSDORG00000011677	Sept14	100	79.064	Dipodomys_ordii
ENSG00000154997	SEPT14	96	81.401	ENSEASG00005008892	SEPT14	96	81.401	Equus_asinus_asinus
ENSG00000154997	SEPT14	100	80.324	ENSECAG00000017362	SEPT14	100	80.324	Equus_caballus
ENSG00000154997	SEPT14	86	83.646	ENSFCAG00000022958	SEPT14	100	83.646	Felis_catus
ENSG00000154997	SEPT14	95	80.622	ENSFDAG00000011391	SEPT14	94	80.622	Fukomys_damarensis
ENSG00000154997	SEPT14	100	99.074	ENSGGOG00000009936	SEPT14	100	99.074	Gorilla_gorilla
ENSG00000154997	SEPT14	100	81.019	ENSHGLG00000016394	SEPT14	100	81.019	Heterocephalus_glaber_female
ENSG00000154997	SEPT14	100	81.250	ENSHGLG00100015461	SEPT14	100	81.250	Heterocephalus_glaber_male
ENSG00000154997	SEPT14	96	84.541	ENSSTOG00000002386	SEPT14	100	84.541	Ictidomys_tridecemlineatus
ENSG00000154997	SEPT14	81	70.655	ENSJJAG00000014604	Sept14	99	70.655	Jaculus_jaculus
ENSG00000154997	SEPT14	100	97.222	ENSMFAG00000033685	SEPT14	100	97.222	Macaca_fascicularis
ENSG00000154997	SEPT14	100	97.222	ENSMMUG00000046200	SEPT14	100	97.222	Macaca_mulatta
ENSG00000154997	SEPT14	100	91.435	ENSMNEG00000017083	SEPT14	100	91.435	Macaca_nemestrina
ENSG00000154997	SEPT14	76	86.890	ENSMLEG00000032329	SEPT14	100	86.890	Mandrillus_leucophaeus
ENSG00000154997	SEPT14	50	80.184	ENSMAUG00000001341	-	99	80.184	Mesocricetus_auratus
ENSG00000154997	SEPT14	100	76.620	ENSMOCG00000020609	Sept14	100	76.620	Microtus_ochrogaster
ENSG00000154997	SEPT14	100	76.852	MGP_CAROLIEiJ_G0027783	Sept14	100	76.852	Mus_caroli
ENSG00000154997	SEPT14	100	77.083	MGP_SPRETEiJ_G0028782	Sept14	100	77.083	Mus_spretus
ENSG00000154997	SEPT14	63	84.559	ENSMPUG00000016236	SEPT14	92	84.559	Mustela_putorius_furo
ENSG00000154997	SEPT14	96	78.986	ENSMLUG00000014804	SEPT14	98	78.986	Myotis_lucifugus
ENSG00000154997	SEPT14	96	84.058	ENSODEG00000014211	SEPT14	100	84.058	Octodon_degus
ENSG00000154997	SEPT14	97	75.059	ENSOGAG00000007701	SEPT14	97	75.059	Otolemur_garnettii
ENSG00000154997	SEPT14	86	99.196	ENSPPAG00000024063	SEPT14	100	99.196	Pan_paniscus
ENSG00000154997	SEPT14	72	84.194	ENSPPRG00000022954	SEPT14	90	83.280	Panthera_pardus
ENSG00000154997	SEPT14	100	80.787	ENSPTIG00000020015	SEPT14	100	80.787	Panthera_tigris_altaica
ENSG00000154997	SEPT14	99	99.301	ENSPTRG00000045367	-	99	99.301	Pan_troglodytes
ENSG00000154997	SEPT14	100	99.306	ENSPTRG00000019200	SEPT14	100	99.306	Pan_troglodytes
ENSG00000154997	SEPT14	100	97.222	ENSPANG00000020727	SEPT14	100	97.222	Papio_anubis
ENSG00000154997	SEPT14	100	74.769	ENSPEMG00000004502	Sept14	100	74.769	Peromyscus_maniculatus_bairdii
ENSG00000154997	SEPT14	96	98.068	ENSPPYG00000017548	SEPT14	99	98.068	Pongo_abelii
ENSG00000154997	SEPT14	95	79.268	ENSRNOG00000038495	Sept14	99	79.268	Rattus_norvegicus
ENSG00000154997	SEPT14	100	84.722	ENSRBIG00000032705	SEPT14	100	84.722	Rhinopithecus_bieti
ENSG00000154997	SEPT14	100	96.991	ENSRROG00000035278	SEPT14	100	96.991	Rhinopithecus_roxellana
ENSG00000154997	SEPT14	100	93.287	ENSSBOG00000010995	SEPT14	100	93.287	Saimiri_boliviensis_boliviensis
ENSG00000154997	SEPT14	86	73.190	ENSTTRG00000001656	-	100	73.190	Tursiops_truncatus
ENSG00000154997	SEPT14	86	83.914	ENSVVUG00000018916	SEPT14	91	83.914	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	17922164.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005940	septin ring	21873635.	IBA	Component
GO:0015630	microtubule cytoskeleton	21873635.	IBA	Component
GO:0031105	septin complex	21873635.	IBA	Component
GO:0060090	molecular adaptor activity	21873635.	IBA	Function
GO:0061640	cytoskeleton-dependent cytokinesis	21873635.	IBA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.