EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22472896Mena, a new available marker in tumors of salivary glands?Eur J Histochem2012 Feb 7Gurzu Sdoi: 10.4081/ejh.2012.e8.
18985426Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.Clin Exp Metastasis2009Goswami Sdoi: 10.1007/s10585-008-9225-8
29439204hMENA is a key regulator in endothelin-1/β-arrestin1-induced invadopodial function and metastatic process.Proc Natl Acad Sci U S A2018 Mar 20Di Modugno Fdoi: 10.1073/pnas.1715998115
25449779A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer.Cancer Lett2015 Jan 28Nam Sdoi: 10.1016/j.canlet.2014.10.038
21209853The cooperation between hMena overexpression and HER2 signalling in breast cancer.PLoS One2010 Dec 30Di Modugno Fdoi: 10.1371/journal.pone.0015852.
25109497Relative expression of hMena11a and hMenaINV splice isoforms is a useful biomarker in development and progression of human breast carcinoma.Int J Oncol2014 NovTanaka Ndoi: 10.3892/ijo.2014.2591
22971274Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer.Breast Cancer Res2012 Sep 12Agarwal Sdoi: 10.1186/bcr3318.
25961924hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.Oncogene2016 Feb 18Trono Pdoi: 10.1038/onc.2015.143
16533770The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors.Clin Cancer Res2006 Mar 1Di Modugno F-
275977545'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.J Cell Biol2016 Sep 12Rajadurai CVdoi: 10.1083/jcb.201501003
27748415The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior.Sci Rep2016 Oct 17Balsamo Mdoi: 10.1038/srep35298.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1225514964Intronnovel0.35
BLCAchr1225530600Missense_MutationnovelQ130E0.13
BLCAchr1225498378Missense_MutationnovelE569D0.13
BLCAchr1225512908Missense_MutationnovelG443S0.37
BLCAchr1225512952Missense_MutationnovelT428R0.43
BLCAchr1225514903Splice_Regionnovel0.43
BRCAchr1225512984SilentNAN417N0.33
BRCAchr1225512923Missense_MutationNAP438S0.17
BRCAchr1225555081Splice_RegionNAV58V0.18
BRCAchr1225519401Missense_MutationNAR200P0.11
BRCAchr12254974533'UTRnovel0.08
BRCAchr1225519400SilentNAR200R0.3
BRCAchr1225554963Missense_MutationNAN98D0.44
BRCAchr1225512967Missense_MutationNAS423Y0.2
BRCAchr1225514645Missense_MutationNAT390I0.49
BRCAchr1225498344Splice_Regionnovel0.15
BRCAchr1225514944Intronnovel0.3
CESCchr1225555008Missense_MutationnovelA83T0.24
CESCchr1225514722SilentNAP364P0.52
CESCchr1225519219Missense_MutationNAE261K0.48
CESCchr1225519532SilentNAL156L0.44
CESCchr1225511832Missense_Mutationrs549324711A484T0.23
CESCchr12254948493'UTRnovel0.51
CESCchr12254958103'UTRnovel0.24
CESCchr1225519367Silentrs201432124E211E0.15
CESCchr1225517717IntronNA0.31
CESCchr1225511850Missense_MutationNAE478K0.37
CESCchr12254973593'UTRnovel0.35
COADchr1225519261Nonsense_MutationNAR247*0.12
COADchr1225511831Missense_MutationNAA484V0.19
COADchr1225514624Missense_Mutationrs781433637A397V0.47
COADchr1225505033Frame_Shift_DelNAN520Ifs*390.28
COADchr1225517695IntronNA0.36
COADchr1225514903Splice_Regionrs7631848810.34
COADchr1225515031Intronnovel0.57
COADchr1225519356Missense_Mutationrs149587286R215H0.26
COADchr1225514683Missense_MutationNAF377L0.39
COADchr1225519414Frame_Shift_InsNAQ196Dfs*570.22
DLBCchr1225514860SilentnovelP318P0.15
ESCAchr1225519338Missense_MutationnovelR221H0.16
ESCAchr12254974423'UTRnovel0.19
ESCAchr12254968933'UTRnovel0.27
ESCAchr12254968763'UTRnovel0.41
ESCAchr1225497794Missense_MutationnovelS586N0.45
ESCAchr12254949583'UTRnovel0.44
GBMchr1225530574Missense_MutationnovelE138D0.42
GBMchr1225530557Missense_MutationnovelR144I0.21
HNSCchr1225514911Intronnovel0.36
HNSCchr1225514665SilentnovelS383S0.19
KIRPchr1225507948Splice_Regionnovel0.15
LGGchr1225519260Missense_Mutationrs780546038R247Q0.3
LUADchr1225514976Intronnovel0.28
LUADchr1225501026Missense_MutationnovelQ549L0.3
LUADchr1225515033Intronnovel0.15
LUADchr1225512876SilentNAA453A0.29
LUADchr1225511850Nonsense_MutationNAE478*0.3
LUADchr1225519282Missense_Mutationrs142024814R240W0.06
LUADchr12254977023'UTRnovel0.21
LUSCchr1225505003Missense_MutationnovelD530V0.14
LUSCchr12254976873'UTRnovel0.25
LUSCchr1225498374Missense_MutationNAT571S0.06
OVchr1225507954Missense_MutationNAS512Y0.26
OVchr1225511831Missense_MutationNAA484V0.06
OVchr1225514610SilentNAR402R0.48
PRADchr1225511832Missense_MutationNAA484S0.25
READchr1225498380Nonsense_MutationnovelE569*0.36
SARCchr1225514763Missense_MutationnovelP351S0.71
SARCchr12254975653'UTRnovel0.33
SKCMchr1225501027Nonsense_MutationnovelQ549*0.37
SKCMchr1225512892Missense_MutationNAM448T0.53
SKCMchr1225514707SilentnovelA369A0.6
SKCMchr1225512923Missense_MutationNAP438S0.23
SKCMchr1225512942Silentrs771348565G431G0.31
SKCMchr1225514796Missense_MutationNAP340S0.71
SKCMchr1225554992Missense_MutationNAG88D0.45
SKCMchr1225505008SilentNAS528S0.48
SKCMchr1225514609Missense_MutationNAR402K0.23
SKCMchr1225514701SilentnovelP371P0.41
SKCMchr1225497780Missense_MutationNAA591S0.12
SKCMchr1225530584Missense_MutationNAP135L0.5
STADchr1225498358Missense_MutationnovelE576A0.28
STADchr1225514905Splice_Regionnovel0.13
STADchr1225519215Missense_Mutationrs370738156R262H0.33
STADchr1225519320Missense_MutationNAQ227R0.24
STADchr1225567405Frame_Shift_InsnovelS5Rfs*100.1
STADchr1225514833SilentnovelS327S0.39
STADchr1225519216Missense_Mutationrs375992317R262C0.26
THYMchr12254956873'UTRnovel0.06
UCECchr1225515157IntronNA0.57
UCECchr12254869343'UTRnovel0.25
UCECchr12254971003'UTRnovel0.38
UCECchr1225519238SilentnovelE254E0.34
UCECchr12254955823'UTRnovel0.22
UCECchr1225501056Missense_MutationnovelP539L0.08
UCECchr12254961833'UTRnovel0.26
UCECchr1225554955SilentnovelF100F0.35
UCECchr1225519539Frame_Shift_DelnovelK154Rfs*230.08
UCECchr12254968303'UTRnovel0.6
UCECchr12254975323'UTRnovel0.06
UCECchr1225515086Intronnovel0.43
UCECchr1225519447Nonsense_MutationNAR185*0.34
UCECchr1225555013Missense_MutationNAR81Q0.12
UCECchr1225567317Missense_MutationNAV35F0.25
UCECchr1225514906Splice_Regionnovel0.26
UCECchr12254962023'UTRnovel0.3
UCECchr12254974153'UTRnovel0.21
UCECchr1225555049Missense_MutationnovelK69T0.33
UCECchr12254965263'UTRnovel0.14
UCECchr12254970143'UTRnovel0.22
UCECchr12254950393'UTRnovel0.35
UCECchr12254957753'UTRnovel0.23
UCECchr1225505052Missense_Mutationrs751822086R514W0.35
UCECchr1225512965Missense_Mutationrs762902163A424T0.25
UCECchr1225519353Missense_MutationnovelL216P0.33
UCECchr1225519357Missense_Mutationrs138096201R215C0.18
UCECchr1225512899Nonsense_MutationnovelE446*0.5
UCECchr1225554965Missense_MutationnovelA97V0.55
UCECchr1225512958Missense_MutationnovelS426Y0.39
UCECchr12254868633'UTRnovel0.37
UCECchr1225514678Missense_MutationnovelL379S0.32
UCECchr1225554947Missense_MutationNAA103V0.38
UCECchr1225501022Silentrs368744442T550T0.2
UCECchr1225507950Splice_SiteNAX513_splice0.38
UCECchr12254972213'UTRnovel0.21
UCECchr12254955753'UTRnovel0.38
UCECchr12254948413'UTRnovel0.59
UCECchr12254976093'UTRnovel0.31
UCECchr12254977583'UTRnovel0.25
UCECchr1225514622Missense_Mutationrs143052362G398R0.37
UCECchr12254965673'UTRnovel0.59
UCECchr1225505045Missense_MutationnovelS516Y0.35
UCECchr12254871533'UTRnovel0.5
UCECchr12254948493'UTRnovel0.16
UCECchr12254967093'UTRnovel0.53
UCECchr12254975243'UTRnovel0.41
UCECchr1225519375Missense_MutationNAR209C0.3
UCECchr12254957233'UTRnovel0.5
UCECchr12254968163'UTRnovel0.26
UCECchr12254975403'UTRrs7667459120.34
UCECchr1225519528Missense_Mutationrs535035689R158W0.06
UCECchr1225512942Silentrs771348565G431G0.22
UCECchr12254968253'UTRnovel0.33
UCECchr1225517215Silentrs765387144A298A0.27
UCECchr12254948493'UTRnovel0.44
UCECchr1225555016Nonsense_MutationnovelW80*0.39
UCECchr1225567337Missense_MutationnovelG28D0.52
UCECchr1225513007Missense_MutationnovelT410A0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.0760.033566
DLBCDEL0.1250.0017831
GBMDEL0.05370.00056261
KIRCDEL0.06630.018371
LGGDEL0.03310.11599
PCPGDEL0.08020.12617
PRADDEL0.06710.00015401
READAMP0.25450.14328
SARCDEL0.29962.6086e-08
TGCTDEL0.03330.16985
THYMAMP0.17890.24554
UCECAMP0.38592.3921e-06

Survival Analysis
CancerP-value Q-value
THYM0.013

Kaplan-Meier Survival Analysis

STAD0.042

Kaplan-Meier Survival Analysis

MESO0.00012

Kaplan-Meier Survival Analysis

ACC0.0036

Kaplan-Meier Survival Analysis

UCS0.023

Kaplan-Meier Survival Analysis

KIRP0.00056

Kaplan-Meier Survival Analysis

PAAD0.01

Kaplan-Meier Survival Analysis

KICH0.0016

Kaplan-Meier Survival Analysis

UCEC0.048

Kaplan-Meier Survival Analysis

GBM0.00037

Kaplan-Meier Survival Analysis

LIHC0.0015

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000154380 (Gene tree)
Gene ID
55740
Gene Symbol
ENAH
Alias
FLJ10773|NDPP1|MENA
Full Name
ENAH actin regulator
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
174,845 bases
Position
chr1:225,486,832-225,661,676
Accession
18271
RBP type
non-canonical RBP
Summary
This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000497899ENAH-207807-ENSP00000489106242 (aa)-A0A0U1RQP7
ENST00000635051ENAH-2093308XM_017001747ENSP00000489607802 (aa)XP_016857236A0A0U1RRM6
ENST00000366844ENAH-20413168XM_011544229ENSP00000355809591 (aa)XP_011542531Q8N8S7
ENST00000366843ENAH-2032758XM_017001749ENSP00000355808570 (aa)XP_016857238Q8N8S7
ENST00000498108ENAH-208713--- (aa)--
ENST00000391874ENAH-205888--- (aa)--
ENST00000284563ENAH-201665-ENSP00000284563213 (aa)-A0A075B6E5
ENST00000483952ENAH-206578--- (aa)--
ENST00000358675ENAH-2023655--- (aa)--
Gene Model
Click here to download ENSG00000154380's gene model file
Pathways
Pathway IDPathway NameSource
hsa04360Axon guidanceKEGG
hsa04810Regulation of actin cytoskeletonKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000154380Blood Pressure6.0605644E-005-
ENSG00000154380Blood Pressure9.3171405E-005-
ENSG00000154380Platelet Function Tests3.4513424E-006-
ENSG00000154380Platelet Function Tests3.1096995E-006-
ENSG00000154380Platelet Function Tests3.4513424E-006-
ENSG00000154380Platelet Function Tests5.9172582E-006-
ENSG00000154380Platelet Function Tests1.0969800E-005-
ENSG00000154380Platelet Function Tests2.8308856E-006-
ENSG00000154380Platelet Function Tests5.4602214E-006-
ENSG00000154380Platelet Function Tests3.4513424E-006-
ENSG00000154380Platelet Function Tests3.5337878E-006-
ENSG00000154380Platelet Function Tests3.4513424E-006-
ENSG00000154380Platelet Function Tests3.1096995E-006-
ENSG00000154380Platelet Function Tests2.9084243E-006-
ENSG00000154380Platelet Function Tests3.1096995E-006-
ENSG00000154380Platelet Function Tests3.1096995E-006-
ENSG00000154380Autistic Disorder3.6109000E-005-
ENSG00000154380Autistic Disorder1.3036000E-005-
ENSG00000154380Autistic Disorder2.8186000E-005-
ENSG00000154380Autistic Disorder3.0195000E-005-
ENSG00000154380Autistic Disorder2.2006000E-005-
ENSG00000154380Autistic Disorder1.1475000E-005-
ENSG00000154380Autistic Disorder5.6826000E-006-
ENSG00000154380Child Development Disorders, Pervasive1.4899100E-005-
ENSG00000154380Child Development Disorders, Pervasive1.0125500E-005-
ENSG00000154380Child Development Disorders, Pervasive1.2083100E-005-
ENSG00000154380Neuroticism2E-827067015
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000154380rs175028581225593528ANeuroticism29942085z score increase5.468EFO_0007660
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000154380's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003779actin binding-IEAFunction
GO:0005515protein binding16979624.21044950.21278383.IPIFunction
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton-IEAComponent
GO:0005886plasma membrane-IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion-IDAComponent
GO:0007411axon guidance-TASProcess
GO:0017124SH3 domain binding-IEAFunction
GO:0030027lamellipodium-IEAComponent
GO:0030054cell junction-IDAComponent
GO:0030175filopodium-IEAComponent
GO:0045202synapse-IEAComponent
GO:0050699WW domain binding17686488.IPIFunction
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us