EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23492366	CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.	Cancer Res	2013 May 1	Burkhardt L	doi: 10.1158/0008-5472.CAN-12-1342
25175909	ERG and CHD1 heterogeneity in prostate cancer: use of confocal microscopy in assessment of microscopic foci.	Prostate	2014 Nov	Tereshchenko IV	doi: 10.1002/pros.22873
19441106	Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival.	Hepatology	2009 Jul	Chen L	doi: 10.1002/hep.22933.
26751641	Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.	Nat Struct Mol Biol	2016 Feb	Metzger E	doi: 10.1038/nsmb.3153
22046413	Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.	PLoS One	2011	Dey P	doi: 10.1371/journal.pone.0026926
22139082	Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer.	Oncogene	2012 Aug 30	Liu W	doi: 10.1038/onc.2011.554
25770290	Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer.	Cancer Res	2015 Mar 15	Rodrigues LU	doi: 10.1158/0008-5472.CAN-14-1596.
27596623	Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.	EMBO Rep	2016 Nov	Kari V	-
28646284	CHD1L Expression Increases Tumor Progression and Acts as a Predictive Biomarker for Poor Prognosis in Pancreatic Cancer.	Dig Dis Sci	2017 Sep	Liu C	doi: 10.1007/s10620-017-4641-8
28383660	CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair.	Ann Oncol	2017 Jul 1	Shenoy TR	doi: 10.1093/annonc/mdx165.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr5	98872313	Intron	NA		0.64
BLCA	chr5	98873707	Nonsense_Mutation	NA	R1153*	0.09
BLCA	chr5	98876501	Missense_Mutation	NA	D1099Y	0.06
BLCA	chr5	98882030	Missense_Mutation	novel	Q938E	0.14
BLCA	chr5	98860070	Splice_Site	NA	X1476_splice	0.17
BLCA	chr5	98897233	Nonsense_Mutation	novel	Q485*	0.26	ResIII
BLCA	chr5	98899616	Nonsense_Mutation	novel	Q317*	0.3
BLCA	chr5	98858361	Missense_Mutation	novel	H1536Y	0.39
BLCA	chr5	98893531	Missense_Mutation	novel	L626V	0.41	ResIII
BLCA	chr5	98879629	Nonsense_Mutation	novel	R1054*	0.42
BLCA	chr5	98901054	Missense_Mutation	novel	L206I	0.59
BLCA	chr5	98872103	Missense_Mutation	NA	Y1270C	0.18
BLCA	chr5	98872433	Missense_Mutation	novel	P1232A	0.28
BLCA	chr5	98870704	Frame_Shift_Ins	NA	*E1321Rfs17**	0.15
BLCA	chr5	98896371	Missense_Mutation	NA	Y522C	0.07	ResIII
BLCA	chr5	98879715	Nonsense_Mutation	NA	S1025*	0.25
BLCA	chr5	98892625	Silent	NA	L694L	0.31
BLCA	chr5	98883179	Missense_Mutation	novel	A876G	0.13
BLCA	chr5	98859016	Splice_Site	novel	X1509_splice	0.43
BLCA	chr5	98900987	Missense_Mutation	NA	D228G	0.42
BLCA	chr5	98904939	Missense_Mutation	NA	E71D	0.4
BLCA	chr5	98856609	Nonsense_Mutation	novel	S1635*	0.07
BRCA	chr5	98889197	Missense_Mutation	novel	S741Y	0.05
BRCA	chr5	98902915	Missense_Mutation	novel	R141K	0.26
BRCA	chr5	98893536	Missense_Mutation	NA	S624C	0.29	ResIII
BRCA	chr5	98899633	Missense_Mutation	NA	K311R	0.16
BRCA	chr5	98900982	Silent	NA	R230R	0.28
BRCA	chr5	98901040	Frame_Shift_Ins	NA	*R211Efs4**	0.14
BRCA	chr5	98902920	Silent	NA	V139V	0.12
BRCA	chr5	98883107	Missense_Mutation	NA	R900Q	0.28
BRCA	chr5	98889223	Missense_Mutation	NA	R732S	0.27
BRCA	chr5	98893547	Missense_Mutation	NA	K620N	0.14	ResIII
BRCA	chr5	98898715	Missense_Mutation	NA	E379K	0.23
BRCA	chr5	98905045	Missense_Mutation	NA	S36C	0.32
BRCA	chr5	98870704	Frame_Shift_Ins	NA	*E1321Rfs17**	0.44
BRCA	chr5	98888146	Frame_Shift_Ins	NA	*M813Nfs39**	0.6
CESC	chr5	98881991	Missense_Mutation	novel	G951C	0.63
CESC	chr5	98901052	Silent	novel	L206L	0.41
CESC	chr5	98868551	Missense_Mutation	NA	E1398K	0.36
CESC	chr5	98869868	Frame_Shift_Del	novel	*R1331Kfs6**	0.29
CESC	chr5	98869869	In_Frame_Ins	novel	R1331delinsNW	0.33
CESC	chr5	98876550	Silent	NA	F1082F	0.46
CESC	chr5	98876436	Silent	novel	R1120R	0.25
CESC	chr5	98879628	Missense_Mutation	rs768256433	R1054Q	0.4
CESC	chr5	98882110	Missense_Mutation	NA	R911H	0.26
CESC	chr5	98888230	Missense_Mutation	novel	R785H	0.23
CESC	chr5	98896388	Silent	novel	T516T	0.44
CESC	chr5	98900995	Silent	novel	Y225Y	0.45
CESC	chr5	98905027	Missense_Mutation	novel	G42E	0.13
CESC	chr5	98893430	Silent	novel	F659F	0.38
CESC	chr5	98892533	Silent	novel	Q724Q	0.14
CESC	chr5	98893453	Missense_Mutation	NA	E652Q	0.48
CHOL	chr5	98905037	Missense_Mutation	novel	S39G	0.41
CHOL	chr5	98855440	3'UTR	novel		0.29
COAD	chr5	98872313	Intron	NA		0.52
COAD	chr5	98876483	Missense_Mutation	NA	E1105K	0.38
COAD	chr5	98898748	Missense_Mutation	NA	P368S	0.28
COAD	chr5	98856681	Missense_Mutation	novel	R1611M	0.07
COAD	chr5	98873598	Missense_Mutation	NA	R1189Q	0.28
COAD	chr5	98863576	Missense_Mutation	NA	R1420I	0.3
COAD	chr5	98892628	Missense_Mutation	novel	F693I	0.09
COAD	chr5	98901041	Frame_Shift_Del	NA	*K210Rfs39**	0.24
COAD	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.07
COAD	chr5	98900972	Missense_Mutation	NA	R233H	0.29
COAD	chr5	98879550	Splice_Site	novel	X1079_splice	0.1
COAD	chr5	98896441	Missense_Mutation	NA	G499R	0.16	ResIII
COAD	chr5	98903895	Missense_Mutation	novel	S90N	0.25
COAD	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.3
COAD	chr5	98894666	Silent	rs148360350	T577T	0.24
COAD	chr5	98876438	Missense_Mutation	rs768739262	R1120W	0.36
COAD	chr5	98901004	In_Frame_Ins	NA	D221dup	0.31
COAD	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.36
COAD	chr5	98856277	3'UTR	novel		0.38
COAD	chr5	98872313	Intron	novel		0.54
COAD	chr5	98898326	Frame_Shift_Del	novel	*K432Vfs6**	0.22
COAD	chr5	98872313	Intron	NA		0.34
COAD	chr5	98900828	Missense_Mutation	novel	R281Q	0.16
COAD	chr5	98870704	Frame_Shift_Ins	NA	*E1321Rfs17**	0.48
COAD	chr5	98872313	Intron	NA		0.5
COAD	chr5	98875096	Missense_Mutation	NA	K1139T	0.19
COAD	chr5	98902940	Missense_Mutation	rs368581644	D133N	0.14
COAD	chr5	98858246	Missense_Mutation	NA	R1574I	0.3
COAD	chr5	98863550	Missense_Mutation	NA	K1429Q	0.36
COAD	chr5	98868595	Missense_Mutation	novel	K1383T	0.28
COAD	chr5	98885602	Silent	NA	D848D	0.38
COAD	chr5	98876461	Missense_Mutation	novel	R1112H	0.09
COAD	chr5	98882003	Frame_Shift_Del	novel	*V947Tfs15**	0.21
COAD	chr5	98899631	Nonsense_Mutation	novel	E312*	0.05
COAD	chr5	98893560	Frame_Shift_Ins	novel	*A616Gfs13**	0.09	ResIII
COAD	chr5	98888143	Missense_Mutation	novel	V814A	0.49
COAD	chr5	98901041	Frame_Shift_Del	NA	*K210Rfs39**	0.09
COAD	chr5	98901040	Frame_Shift_Ins	NA	*R211Efs4**	0.2
ESCA	chr5	98888147	Missense_Mutation	novel	M813V	0.49
ESCA	chr5	98858298	Missense_Mutation	novel	H1557Y	0.22
ESCA	chr5	98875084	Missense_Mutation	novel	G1143D	0.34
ESCA	chr5	98898271	Silent	novel	P450P	0.21
ESCA	chr5	98882105	Missense_Mutation	novel	V913I	0.11
ESCA	chr5	98896347	Missense_Mutation	novel	Y530C	0.13	ResIII
ESCA	chr5	98868530	Missense_Mutation	novel	E1405K	0.25
GBM	chr5	98856631	Missense_Mutation	NA	H1628Y	0.2
GBM	chr5	98863469	Missense_Mutation	novel	D1456Y	0.25
GBM	chr5	98863564	Missense_Mutation	novel	V1424A	0.07
GBM	chr5	98869825	Missense_Mutation	novel	K1346Q	0.24
GBM	chr5	98873598	Missense_Mutation	NA	R1189Q	0.32
GBM	chr5	98883139	Missense_Mutation	novel	Q889H	0.24
GBM	chr5	98894650	Missense_Mutation	NA	R583W	0.19	ResIII
GBM	chr5	98897202	Missense_Mutation	novel	S495Y	0.24	ResIII
GBM	chr5	98868548	Missense_Mutation	novel	P1399S	0.07
GBM	chr5	98896346	Nonsense_Mutation	novel	Y530*	0.25	ResIII
HNSC	chr5	98858378	In_Frame_Ins	novel	R1529_L1530insWSLPL	0.05
HNSC	chr5	98901300	Missense_Mutation	novel	S158C	0.23
HNSC	chr5	98873706	Missense_Mutation	novel	R1153Q	0.23
HNSC	chr5	98899616	Missense_Mutation	novel	Q317E	0.19
HNSC	chr5	98856364	3'UTR	rs767701099		0.38
HNSC	chr5	98897321	Splice_Site	novel	X456_splice	0.24
HNSC	chr5	98858266	Missense_Mutation	novel	K1567N	0.45
KICH	chr5	98856377	3'UTR	novel		0.28
KIRC	chr5	98892605	Silent	novel	K700K	0.49
KIRC	chr5	98882066	Missense_Mutation	NA	A926T	0.28
KIRC	chr5	98903845	Nonsense_Mutation	novel	*Q107Ffs5**	0.04
KIRC	chr5	98868590	Missense_Mutation	NA	S1385A	0.19
KIRP	chr5	98856595	Missense_Mutation	NA	H1640Y	0.65
KIRP	chr5	98860006	Missense_Mutation	rs749012080	Y1497C	0.63
KIRP	chr5	98899528	Missense_Mutation	novel	M346K	0.33
KIRP	chr5	98901270	Missense_Mutation	rs370850474	E168G	0.47
KIRP	chr5	98926479	5'UTR	novel		0.53
LGG	chr5	98872160	Missense_Mutation	rs200447490	I1251T	0.08
LGG	chr5	98896359	Missense_Mutation	novel	E526V	0.16	ResIII
LGG	chr5	98858288	Missense_Mutation	rs72775611	R1560Q	0.36
LGG	chr5	98873687	Silent	novel	D1159D	0.4
LIHC	chr5	98876432	Missense_Mutation	NA	N1122D	0.27
LIHC	chr5	98898329	Missense_Mutation	novel	K431T	0.22
LIHC	chr5	98893527	Missense_Mutation	novel	Y627C	0.06	ResIII
LIHC	chr5	98856712	Nonsense_Mutation	novel	R1601*	0.4
LIHC	chr5	98888128	Frame_Shift_Ins	novel	*I819Nfs33**	0.1
LUAD	chr5	98901193	Missense_Mutation	NA	Q194E	0.23
LUAD	chr5	98856563	Silent	NA	T1650T	0.11
LUAD	chr5	98900827	Silent	novel	R281R	0.06
LUAD	chr5	98889175	Missense_Mutation	NA	F748L	0.19
LUAD	chr5	98868621	Missense_Mutation	novel	K1374N	0.22
LUAD	chr5	98875085	Missense_Mutation	NA	G1143C	0.3
LUAD	chr5	98889082	Silent	novel	A779A	0.32
LUSC	chr5	98901191	Missense_Mutation	novel	Q194H	0.32
LUSC	chr5	98858982	Missense_Mutation	novel	H1520Y	0.39
LUSC	chr5	98898407	Missense_Mutation	NA	G405V	0.73
LUSC	chr5	98856725	Splice_Region	novel	R1596R	0.38
LUSC	chr5	98903838	Missense_Mutation	novel	Q109R	0.07
LUSC	chr5	98903839	Nonsense_Mutation	novel	Q109*	0.08
LUSC	chr5	98879628	Missense_Mutation	novel	R1054P	0.2
LUSC	chr5	98876428	Missense_Mutation	novel	I1123S	0.35
LUSC	chr5	98896299	Missense_Mutation	NA	Q546P	0.29	ResIII
LUSC	chr5	98902949	Missense_Mutation	novel	E130K	0.36
LUSC	chr5	98888196	Silent	rs752845055	L796L	0.42
LUSC	chr5	98872322	Intron	novel		0.4
LUSC	chr5	98892618	Missense_Mutation	novel	R696H	0.24
LUSC	chr5	98892646	Missense_Mutation	NA	H687N	0.28
LUSC	chr5	98926386	Translation_Start_Site	NA	M1?	0.26
LUSC	chr5	98893544	Silent	novel	N621N	0.18
LUSC	chr5	98899570	Missense_Mutation	NA	W332S	0.46
OV	chr5	98901058	Missense_Mutation	NA	K204N	0.82
OV	chr5	98858183	Missense_Mutation	novel	S1595I	0.08
OV	chr5	98893459	Missense_Mutation	novel	L650F	0.09
OV	chr5	98893416	Missense_Mutation	novel	K664M	0.11
OV	chr5	98879705	Splice_Site	novel	X1021_splice	0.4
OV	chr5	98856430	Missense_Mutation	novel	V1695L	0.31
OV	chr5	98926339	Silent	novel	E16E	0.08
OV	chr5	98889085	Missense_Mutation	NA	E778D	0.22
OV	chr5	98892696	Frame_Shift_Ins	novel	*D670Vfs3**	0.07
OV	chr5	98856189	3'UTR	novel		0.1
PAAD	chr5	98873624	Silent	novel	L1180L	0.2
PRAD	chr5	98869768	Frame_Shift_Ins	novel	*E1365Mfs7**	0.45
PRAD	chr5	98881103	Silent	novel	V1011V	0.23
PRAD	chr5	98883107	Missense_Mutation	NA	R900Q	0.31
PRAD	chr5	98893573	Missense_Mutation	NA	G612R	0.89	ResIII
PRAD	chr5	98893466	In_Frame_Ins	novel	Q647delinsHSIFLIAFCLFER	0.05
PRAD	chr5	98856468	Missense_Mutation	NA	R1682K	0.74
PRAD	chr5	98856470	Silent	rs772098911	Q1681Q	0.73
PRAD	chr5	98856636	Missense_Mutation	NA	R1626T	0.8
PRAD	chr5	98856521	Nonsense_Mutation	novel	W1664*	0.1
PRAD	chr5	98856671	Silent	novel	D1614D	0.36
PRAD	chr5	98859986	Missense_Mutation	rs779411940	R1504W	0.33
READ	chr5	98876501	Missense_Mutation	NA	D1099H	0.14
READ	chr5	98856641	Missense_Mutation	NA	K1624N	0.47
READ	chr5	98888189	Missense_Mutation	novel	R799C	0.44
READ	chr5	98872144	Missense_Mutation	novel	E1256D	0.05
READ	chr5	98856485	Silent	novel	R1676R	0.42
READ	chr5	98900981	Missense_Mutation	novel	R230I	0.4
SARC	chr5	98900954	Missense_Mutation	novel	N239I	0.16
SARC	chr5	98905065	Silent	novel	G29G	0.09
SKCM	chr5	98876448	Silent	NA	R1116R	0.24
SKCM	chr5	98894650	Missense_Mutation	NA	R583W	0.39	ResIII
SKCM	chr5	98894651	Missense_Mutation	novel	K582N	0.39	ResIII
SKCM	chr5	98900882	Missense_Mutation	novel	V263D	0.44
SKCM	chr5	98900883	Missense_Mutation	novel	V263I	0.44
SKCM	chr5	98863523	Missense_Mutation	NA	L1438F	0.55
SKCM	chr5	98872417	Missense_Mutation	NA	Q1237R	0.39
SKCM	chr5	98858333	Missense_Mutation	NA	S1545F	0.47
SKCM	chr5	98899527	Missense_Mutation	NA	M346I	0.35
SKCM	chr5	98881074	Splice_Site	novel	X1020_splice	0.11
SKCM	chr5	98882111	Missense_Mutation	novel	R911C	0.36
SKCM	chr5	98896345	Nonsense_Mutation	NA	G531*	0.32	ResIII
SKCM	chr5	98870753	Silent	NA	T1304T	0.35
SKCM	chr5	98893513	Missense_Mutation	NA	D632N	0.28	ResIII
SKCM	chr5	98858989	Silent	novel	L1517L	0.19
SKCM	chr5	98872432	Missense_Mutation	NA	P1232L	0.36
SKCM	chr5	98892617	Silent	NA	R696R	0.32
SKCM	chr5	98888105	Missense_Mutation	NA	R827C	0.27
SKCM	chr5	98881113	Missense_Mutation	novel	P1008L	0.2
SKCM	chr5	98893489	Missense_Mutation	NA	L640F	0.4	ResIII
SKCM	chr5	98870694	Missense_Mutation	novel	S1324F	0.58
STAD	chr5	98872313	Intron	novel		0.2
STAD	chr5	98901041	Frame_Shift_Del	NA	*K210Rfs39**	0.25
STAD	chr5	98872313	Intron	NA		0.42
STAD	chr5	98858227	Silent	NA	S1580S	0.23
STAD	chr5	98856214	3'UTR	novel		0.3
STAD	chr5	98873601	Missense_Mutation	NA	E1188G	0.33
STAD	chr5	98869777	Missense_Mutation	novel	K1362Q	0.44
STAD	chr5	98872314	Intron	novel		0.29
STAD	chr5	98872313	Intron	NA		0.48
STAD	chr5	98901041	Frame_Shift_Del	NA	*K210Rfs39**	0.27
STAD	chr5	98900973	Missense_Mutation	NA	R233C	0.1
STAD	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.08
STAD	chr5	98901041	Frame_Shift_Del	NA	*K210Rfs39**	0.29
STAD	chr5	98872313	Intron	novel		0.21
STAD	chr5	98899530	Silent	novel	G345G	0.3
STAD	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.1
STAD	chr5	98885590	Silent	NA	A852A	0.35
STAD	chr5	98888210	Missense_Mutation	rs758876162	L792I	0.29
STAD	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.2
STAD	chr5	98900815	Frame_Shift_Del	novel	*G286Efs34**	0.17
STAD	chr5	98872313	Intron	novel		0.48
STAD	chr5	98899484	Frame_Shift_Del	novel	*R361Dfs3**	0.24
STAD	chr5	98872313	Intron	NA		0.52
STAD	chr5	98872186	Silent	novel	C1242C	0.07
STAD	chr5	98858210	Missense_Mutation	novel	R1586H	0.35
STAD	chr5	98872369	Intron	novel		0.24
STAD	chr5	98873598	Missense_Mutation	NA	R1189Q	0.14
STAD	chr5	98905093	Missense_Mutation	rs778115031	S20L	0.24
TGCT	chr5	98898419	Missense_Mutation	novel	K401M	0.19
THCA	chr5	98897206	Missense_Mutation	novel	H494Y	0.37	ResIII
UCEC	chr5	98901016	Missense_Mutation	novel	E218D	0.38
UCEC	chr5	98863445	Nonsense_Mutation	NA	E1464*	0.3
UCEC	chr5	98868597	Missense_Mutation	NA	K1382N	0.29
UCEC	chr5	98926384	Translation_Start_Site	NA	M1?	0.35
UCEC	chr5	98897293	Missense_Mutation	novel	A465T	0.11
UCEC	chr5	98898272	Missense_Mutation	NA	P450H	0.39
UCEC	chr5	98900812	Splice_Region	novel	G286G	0.3
UCEC	chr5	98897196	Missense_Mutation	NA	C497Y	0.34	ResIII
UCEC	chr5	98856263	3'UTR	novel		0.31
UCEC	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.53
UCEC	chr5	98883086	Splice_Site	novel	X906_splice	0.32
UCEC	chr5	98885631	Missense_Mutation	novel	K839Q	0.42
UCEC	chr5	98897282	Silent	novel	K468K	0.48
UCEC	chr5	98900853	Missense_Mutation	novel	T273P	0.29
UCEC	chr5	98896378	Missense_Mutation	novel	L520V	0.18	ResIII
UCEC	chr5	98883197	Missense_Mutation	NA	G870V	0.19
UCEC	chr5	98881371	Missense_Mutation	novel	T958A	0.41
UCEC	chr5	98905017	Silent	novel	S45S	0.36
UCEC	chr5	98894597	Splice_Region	novel	K600K	0.28
UCEC	chr5	98901336	Splice_Site	novel	X146_splice	0.11
UCEC	chr5	98888188	Missense_Mutation	NA	R799H	0.36
UCEC	chr5	98872092	Missense_Mutation	NA	E1274K	0.17
UCEC	chr5	98873620	Missense_Mutation	novel	D1182N	0.06
UCEC	chr5	98856666	Missense_Mutation	NA	R1616M	0.21
UCEC	chr5	98879672	Missense_Mutation	NA	N1039K	0.15
UCEC	chr5	98856503	Silent	NA	A1670A	0.46
UCEC	chr5	98872313	Intron	NA		1
UCEC	chr5	98926384	Translation_Start_Site	NA	M1?	0.11
UCEC	chr5	98872313	Intron	NA		0.6
UCEC	chr5	98879628	Missense_Mutation	rs768256433	R1054Q	0.39
UCEC	chr5	98856391	Missense_Mutation	rs200109773	R1708W	0.34
UCEC	chr5	98904920	Missense_Mutation	novel	P78T	0.1
UCEC	chr5	98899601	Missense_Mutation	novel	W322R	0.26
UCEC	chr5	98896335	Frame_Shift_Del	novel	*L534Yfs3**	0.22	ResIII
UCEC	chr5	98855238	3'UTR	novel		0.42
UCEC	chr5	98872313	Intron	NA		0.44
UCEC	chr5	98876530	Missense_Mutation	rs370090244	R1089H	0.36
UCEC	chr5	98888188	Missense_Mutation	NA	R799H	0.33
UCEC	chr5	98896283	Silent	novel	T551T	0.36
UCEC	chr5	98898325	Frame_Shift_Ins	novel	*F433Vfs6**	0.34
UCEC	chr5	98856583	Missense_Mutation	rs146540815	R1644W	0.38
UCEC	chr5	98868569	Missense_Mutation	NA	H1392Y	0.33
UCEC	chr5	98872313	Intron	NA		0.32
UCEC	chr5	98883222	Silent	novel	L862L	0.45
UCEC	chr5	98873598	Missense_Mutation	NA	R1189Q	0.33
UCEC	chr5	98897248	Missense_Mutation	novel	E480K	0.1	ResIII
UCEC	chr5	98872440	Silent	novel	P1229P	0.1
UCEC	chr5	98856364	3'UTR	rs767701099		0.41
UCEC	chr5	98856618	Missense_Mutation	novel	R1632H	0.44
UCEC	chr5	98860064	Missense_Mutation	novel	L1478M	0.41
UCEC	chr5	98868526	Missense_Mutation	novel	S1406Y	0.39
UCEC	chr5	98888188	Missense_Mutation	NA	R799H	0.48
UCEC	chr5	98894641	Missense_Mutation	novel	F586I	0.4	ResIII
UCEC	chr5	98856640	Frame_Shift_Ins	novel	*D1625Rfs2**	0.48
UCEC	chr5	98896335	Frame_Shift_Del	novel	*L534Yfs3**	0.52	ResIII
UCEC	chr5	98897252	Silent	novel	G478G	0.49
UCEC	chr5	98900819	Missense_Mutation	novel	R284I	0.45
UCEC	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.41
UCEC	chr5	98863574	Missense_Mutation	novel	M1421V	0.07
UCEC	chr5	98873598	Missense_Mutation	NA	R1189Q	0.3
UCEC	chr5	98859987	Frame_Shift_Del	novel	*K1503Nfs15**	0.42
UCEC	chr5	98904915	Silent	novel	P79P	0.47
UCEC	chr5	98881129	Nonsense_Mutation	novel	E1003*	0.18
UCEC	chr5	98883107	Missense_Mutation	NA	R900Q	0.33
UCEC	chr5	98881093	Silent	novel	L1015L	0.26
UCEC	chr5	98901033	Frame_Shift_Del	novel	*Q212Lfs36**	0.4
UCEC	chr5	98879600	Silent	NA	E1063E	0.45
UCEC	chr5	98873598	Missense_Mutation	NA	R1189Q	0.26
UCEC	chr5	98888176	Missense_Mutation	novel	R803Q	0.12
UCEC	chr5	98894602	Missense_Mutation	novel	D599Y	0.08	ResIII
UCEC	chr5	98859987	Frame_Shift_Del	novel	*K1503Nfs15**	0.15
UCEC	chr5	98894649	Missense_Mutation	novel	R583Q	0.42	ResIII
UCEC	chr5	98868498	Silent	novel	S1415S	0.4
UCEC	chr5	98868499	Missense_Mutation	rs147154039	S1415N	0.41
UCEC	chr5	98881301	Missense_Mutation	novel	E981G	0.29
UCEC	chr5	98858277	Missense_Mutation	novel	D1564Y	0.39
UCEC	chr5	98872078	Missense_Mutation	novel	M1278I	0.22
UCEC	chr5	98873598	Missense_Mutation	NA	R1189Q	0.35
UCEC	chr5	98889107	Missense_Mutation	novel	N771T	0.38
UCEC	chr5	98894615	Silent	rs536544766	E594E	0.39
UCEC	chr5	98903878	Missense_Mutation	rs34128229	V96I	0.24
UCEC	chr5	98872313	Intron	NA		0.38
UCEC	chr5	98904957	Silent	novel	E65E	0.08
UCEC	chr5	98856673	Missense_Mutation	novel	D1614Y	0.45
UCEC	chr5	98892638	Silent	novel	E689E	0.44
UCEC	chr5	98900931	Missense_Mutation	novel	E247K	0.35
UCEC	chr5	98858246	Missense_Mutation	NA	R1574I	0.25
UCEC	chr5	98872338	Intron	novel		0.11
UCEC	chr5	98893513	Missense_Mutation	novel	D632Y	0.13	ResIII
UCEC	chr5	98896388	Silent	novel	T516T	0.24
UCEC	chr5	98903794	Nonsense_Mutation	novel	E124*	0.12
UCEC	chr5	98856155	3'UTR	novel		0.8
UCEC	chr5	98856545	Missense_Mutation	novel	R1656S	0.33
UCEC	chr5	98856665	Silent	novel	R1616R	0.41
UCEC	chr5	98870756	Missense_Mutation	novel	Q1303H	0.36
UCEC	chr5	98873644	Missense_Mutation	novel	N1174D	0.2
UCEC	chr5	98879603	Missense_Mutation	novel	K1062N	0.34
UCEC	chr5	98888167	Missense_Mutation	novel	R806Q	0.4
UCEC	chr5	98892616	Nonsense_Mutation	NA	R697*	0.27
UCEC	chr5	98872313	Intron	NA		0.78
UCEC	chr5	98872552	Missense_Mutation	novel	G1192V	0.16
UCEC	chr5	98872313	Intron	NA		0.62
UCEC	chr5	98858320	Missense_Mutation	novel	H1549Q	0.34
UCEC	chr5	98870705	Frame_Shift_Del	NA	*E1321Kfs22**	0.42
UCEC	chr5	98883228	Missense_Mutation	novel	F860L	0.28
UCEC	chr5	98900828	Missense_Mutation	novel	R281Q	0.24
UCEC	chr5	98855299	3'UTR	novel		0.32
UCEC	chr5	98885595	Frame_Shift_Ins	novel	N851*	0.37
UCEC	chr5	98872469	Nonsense_Mutation	NA	E1220*	0.87
UCEC	chr5	98899579	Missense_Mutation	NA	H329R	0.48
UCEC	chr5	98872303	Intron	novel		0.36
UCEC	chr5	98893554	Missense_Mutation	novel	R618Q	0.42	ResIII
UCEC	chr5	98899483	Frame_Shift_Ins	novel	*R361Kfs15**	0.36
UCEC	chr5	98901258	Frame_Shift_Ins	novel	*K172Rfs78**	0.34
UCEC	chr5	98872414	Splice_Region	novel		0.44
UCEC	chr5	98873598	Missense_Mutation	NA	R1189Q	0.34
UCEC	chr5	98902903	Missense_Mutation	NA	K145T	0.24
UCEC	chr5	98856377	3'UTR	novel		0.25
UCEC	chr5	98870785	Missense_Mutation	novel	D1294N	0.51
UCEC	chr5	98872340	Intron	novel		0.28
UCEC	chr5	98876530	Missense_Mutation	rs370090244	R1089H	0.26
UCEC	chr5	98881076	Missense_Mutation	novel	K1020N	0.28
UCEC	chr5	98892618	Missense_Mutation	novel	R696H	0.06
UCEC	chr5	98893573	Missense_Mutation	novel	G612C	0.22	ResIII
UCEC	chr5	98901271	Nonsense_Mutation	novel	E168*	0.47
UCEC	chr5	98904930	Silent	novel	V74V	0.24
UCEC	chr5	98881126	Missense_Mutation	novel	N1004H	0.39
UCEC	chr5	98894605	Missense_Mutation	novel	K598Q	0.37	ResIII
UCEC	chr5	98879560	Missense_Mutation	rs370760984	A1077T	0.46
UCEC	chr5	98869761	Missense_Mutation	NA	D1367G	0.29
UCEC	chr5	98872313	Intron	NA		0.58
UCEC	chr5	98856697	Missense_Mutation	novel	K1606E	0.47
UCEC	chr5	98879603	Frame_Shift_Ins	novel	*E1063Gfs3**	0.4
UCEC	chr5	98856699	Missense_Mutation	novel	R1605K	0.31
UCEC	chr5	98858288	Missense_Mutation	rs72775611	R1560Q	0.36
UCEC	chr5	98888141	Missense_Mutation	rs753957067	R815W	0.24
UCEC	chr5	98899620	Missense_Mutation	novel	E315D	0.39
UCEC	chr5	98872313	Intron	NA		0.5
UCS	chr5	98900972	Missense_Mutation	NA	R233H	0.35
UCS	chr5	98856543	Missense_Mutation	novel	D1657G	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.2217	1.1167e-13
KIRP	DEL	0.0382	0.11554
LUAD	DEL	0.2965	7.4776e-05
LUSC	DEL	0.6647	0.002071
MESO	DEL	0.1494	0.20184
PRAD	DEL	0.2012	4.8919e-36
STAD	DEL	0.2948	2.8835e-08
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0011	Kaplan-Meier Survival Analysis
MESO	0.029	Kaplan-Meier Survival Analysis
ACC	0.02	Kaplan-Meier Survival Analysis
SKCM	0.019	Kaplan-Meier Survival Analysis
KIRP	0.006	Kaplan-Meier Survival Analysis
COAD	0.013	Kaplan-Meier Survival Analysis
PCPG	0.025	Kaplan-Meier Survival Analysis
READ	0.021	Kaplan-Meier Survival Analysis
LAML	0.001	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
CHOL	0.011	Kaplan-Meier Survival Analysis
LUAD	0.04	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000153922 (Gene tree)
Gene ID: 1105
Gene Symbol: CHD1
Alias: N
Full Name: chromodomain helicase DNA binding protein 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 74,973 bases
Position: chr5:98,853,985-98,928,957
Accession: 1915
Summary: The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000284049	ResIII	PF04851.15	8.1e-07	1	1
ENSP00000483667	ResIII	PF04851.15	8.1e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17620414	Chd1 and yFACT act in opposition in regulating transcription.	Mol Cell Biol	2007 Sep	Biswas D	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508756	CHD1-205	724	-	-	- (aa)	-	-
ENST00000614616	CHD1-212	8095	-	ENSP00000483667	1710 (aa)	-	O14646
ENST00000511628	CHD1-207	599	-	-	- (aa)	-	-
ENST00000505657	CHD1-203	736	-	ENSP00000422225	113 (aa)	-	H0Y8V4
ENST00000414220	CHD1-202	434	-	-	- (aa)	-	-
ENST00000284049	CHD1-201	6457	XM_005271866	ENSP00000284049	1710 (aa)	XP_005271924	O14646
ENST00000505982	CHD1-204	758	-	-	- (aa)	-	-
ENST00000512392	CHD1-208	1968	-	-	- (aa)	-	-
ENST00000512844	CHD1-209	848	-	ENSP00000422589	22 (aa)	-	H0Y8Z0
ENST00000514344	CHD1-211	2955	-	-	- (aa)	-	-
ENST00000513064	CHD1-210	786	-	-	- (aa)	-	-
ENST00000511067	CHD1-206	817	-	ENSP00000479403	272 (aa)	-	A0A087WVF4

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000153922	Attention Deficit Disorder with Hyperactivity	1.3270000E-004	18937294
ENSG00000153922	Body Mass Index	7E-7	25673413
ENSG00000153922	Body Mass Index	5E-7	25673413

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000153922	rs11317778	5	98905525	T	Neutrophil percentage of granulocytes	27863252	[0.02-0.036] unit increase	0.02782362	EFO_0007994
ENSG00000153922	rs11317778	5	98905525	T	Eosinophil percentage of granulocytes	27863252	[0.022-0.037] unit decrease	0.0293293	EFO_0007996
ENSG00000153922	rs11317778	5	98905525	T	Eosinophil percentage of white cells	27863252	[0.022-0.037] unit decrease	0.02928997	EFO_0007991
ENSG00000153922	rs11317778	5	98905525	T	Eosinophil counts	27863252	[0.018-0.033] unit decrease	0.02551863	EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000153922's network

Paralog

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000153922	CHD1	95	57.023	ENSG00000173575	CHD2	87	94.898

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000153922	CHD1	67	82.627	ENSAPOG00000005764	chd1	97	82.971	Acanthochromis_polyacanthus
ENSG00000153922	CHD1	95	83.178	ENSAOCG00000023105	chd1	94	77.531	Amphiprion_ocellaris
ENSG00000153922	CHD1	95	83.178	ENSAPEG00000013544	chd1	94	78.721	Amphiprion_percula
ENSG00000153922	CHD1	71	82.319	ENSAMXG00000010843	chd1	91	83.502	Astyanax_mexicanus
ENSG00000153922	CHD1	100	99.299	ENSCATG00000032035	CHD1	100	99.299	Cercocebus_atys
ENSG00000153922	CHD1	100	99.241	ENSCSAG00000015339	CHD1	100	99.241	Chlorocebus_sabaeus
ENSG00000153922	CHD1	100	97.487	ENSCANG00000036916	CHD1	100	97.487	Colobus_angolensis_palliatus
ENSG00000153922	CHD1	100	96.145	ENSCGRG00001023943	Chd1	100	96.145	Cricetulus_griseus_chok1gshd
ENSG00000153922	CHD1	100	96.145	ENSCGRG00000008652	Chd1	100	96.145	Cricetulus_griseus_crigri
ENSG00000153922	CHD1	96	79.817	ENSCSEG00000009553	chd1	92	77.435	Cynoglossus_semilaevis
ENSG00000153922	CHD1	94	92.453	ENSEASG00005016110	CHD1	99	97.923	Equus_asinus_asinus
ENSG00000153922	CHD1	96	80.734	ENSELUG00000017677	chd1	93	78.115	Esox_lucius
ENSG00000153922	CHD1	71	81.255	ENSFHEG00000021164	chd1	87	82.759	Fundulus_heteroclitus
ENSG00000153922	CHD1	91	84.466	ENSGMOG00000001537	chd1	96	67.184	Gadus_morhua
ENSG00000153922	CHD1	91	89.994	ENSGALG00000031327	-	96	90.121	Gallus_gallus
ENSG00000153922	CHD1	96	72.477	ENSGAFG00000019880	chd1	92	82.844	Gambusia_affinis
ENSG00000153922	CHD1	99	96.226	ENSGGOG00000011463	CHD1	99	96.226	Gorilla_gorilla
ENSG00000153922	CHD1	91	84.466	ENSHCOG00000014222	chd1	91	79.678	Hippocampus_comes
ENSG00000153922	CHD1	91	83.495	ENSIPUG00000001369	chd1	92	81.380	Ictalurus_punctatus
ENSG00000153922	CHD1	63	95.154	ENSLAFG00000023183	CHD1	99	95.154	Loxodonta_africana
ENSG00000153922	CHD1	100	99.299	ENSMFAG00000031226	CHD1	100	99.299	Macaca_fascicularis
ENSG00000153922	CHD1	83	99.085	ENSMMUG00000014090	CHD1	99	99.085	Macaca_mulatta
ENSG00000153922	CHD1	100	99.241	ENSMNEG00000045073	CHD1	100	99.241	Macaca_nemestrina
ENSG00000153922	CHD1	99	95.275	ENSMLEG00000041096	CHD1	99	95.688	Mandrillus_leucophaeus
ENSG00000153922	CHD1	72	80.565	ENSMZEG00005010957	chd1	89	83.572	Maylandia_zebra
ENSG00000153922	CHD1	100	93.341	ENSMOCG00000019121	Chd1	100	93.224	Microtus_ochrogaster
ENSG00000153922	CHD1	79	78.267	ENSMALG00000013317	chd1	95	78.072	Monopterus_albus
ENSG00000153922	CHD1	100	94.454	MGP_CAROLIEiJ_G0021099	Chd1	99	96.852	Mus_caroli
ENSG00000153922	CHD1	100	95.738	ENSMUSG00000023852	Chd1	99	97.037	Mus_musculus
ENSG00000153922	CHD1	100	94.396	MGP_PahariEiJ_G0023414	Chd1	99	97.040	Mus_pahari
ENSG00000153922	CHD1	89	76.076	ENSNBRG00000006860	chd1	91	77.741	Neolamprologus_brichardi
ENSG00000153922	CHD1	99	96.952	ENSNLEG00000014493	CHD1	99	96.952	Nomascus_leucogenys
ENSG00000153922	CHD1	100	93.031	ENSOANG00000004891	CHD1	100	94.394	Ornithorhynchus_anatinus
ENSG00000153922	CHD1	59	76.794	ENSORLG00015016725	chd1	93	77.223	Oryzias_latipes_hsok
ENSG00000153922	CHD1	99	98.294	ENSPPAG00000043367	CHD1	99	98.294	Pan_paniscus
ENSG00000153922	CHD1	100	99.708	ENSPTRG00000017103	CHD1	100	99.708	Pan_troglodytes
ENSG00000153922	CHD1	100	99.299	ENSPANG00000006387	CHD1	100	99.299	Papio_anubis
ENSG00000153922	CHD1	94	83.019	ENSPKIG00000024719	chd1	92	79.134	Paramormyrops_kingsleyae
ENSG00000153922	CHD1	73	81.315	ENSPMGG00000005785	chd1	93	81.315	Periophthalmus_magnuspinnatus
ENSG00000153922	CHD1	100	95.911	ENSPEMG00000015939	Chd1	100	95.911	Peromyscus_maniculatus_bairdii
ENSG00000153922	CHD1	50	76.533	ENSPLAG00000006473	-	85	77.765	Poecilia_latipinna
ENSG00000153922	CHD1	96	74.265	ENSPREG00000004209	chd1	97	74.759	Poecilia_reticulata
ENSG00000153922	CHD1	83	95.701	ENSRNOG00000014434	Chd1	99	95.490	Rattus_norvegicus
ENSG00000153922	CHD1	100	96.264	ENSRBIG00000044325	CHD1	100	96.439	Rhinopithecus_bieti
ENSG00000153922	CHD1	100	99.124	ENSRROG00000001726	CHD1	100	99.124	Rhinopithecus_roxellana
ENSG00000153922	CHD1	71	81.766	ENSSFOG00015007161	chd1	90	82.439	Scleropages_formosus
ENSG00000153922	CHD1	79	78.335	ENSSDUG00000018314	chd1	94	77.966	Seriola_dumerili
ENSG00000153922	CHD1	51	83.713	ENSSLDG00000017244	chd1	84	86.019	Seriola_lalandi_dorsalis
ENSG00000153922	CHD1	79	78.835	ENSSPAG00000007024	chd1	95	78.171	Stegastes_partitus
ENSG00000153922	CHD1	92	96.154	ENSSSCG00000014177	CHD1	100	98.106	Sus_scrofa
ENSG00000153922	CHD1	90	75.418	ENSTRUG00000010282	chd1	96	73.418	Takifugu_rubripes
ENSG00000153922	CHD1	72	77.606	ENSTNIG00000007101	chd1	95	78.204	Tetraodon_nigroviridis
ENSG00000153922	CHD1	96	73.394	ENSXCOG00000017184	chd1	91	75.244	Xiphophorus_couchianus
ENSG00000153922	CHD1	77	77.736	ENSXMAG00000014538	chd1	95	78.621	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0004003	ATP-dependent DNA helicase activity	9326634.	TAS	Function
GO:0005515	protein binding	22419161.26751641.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	22046413.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	22046413.	IDA	Component
GO:0006338	chromatin remodeling	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	9326634.	TAS	Process
GO:0016569	covalent chromatin modification	28866611.	IMP	Process
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0035064	methylated histone binding	21029866.	IDA	Function
GO:0035064	methylated histone binding	28866611.	IMP	Function
GO:0043923	positive regulation by host of viral transcription	25297984.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.