EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
11773051Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.J Biol Chem2002 Mar 22Shields JM-
23331552Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer.Cancer Sci2013 AprZhou Ldoi: 10.1111/cas.12107
24476357Transgelins, cytoskeletal proteins implicated in different aspects of cancer development.Expert Rev Proteomics2014 AprDvorakova Mdoi: 10.1586/14789450.2014.860358
19848416Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma.J Proteome Res2009 DecRho JHdoi: 10.1021/pr900705r.
22245152Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy.FEBS Lett2012 Feb 17Kim TRdoi: 10.1016/j.febslet.2011.12.036
26847345Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.BMC Cancer2016 Feb 4Zhou HMdoi: 10.1186/s12885-016-2105-8.
20336793Loss of SM22 is a characteristic signature of colon carcinogenesis and its restoration suppresses colon tumorigenicity in vivo and in vitro.Cancer2010 Jun 1Yeo Mdoi: 10.1002/cncr.25003.
19329940Transgelin as a suppressor is associated with poor prognosis in colorectal carcinoma patients.Mod Pathol2009 JunZhao Ldoi: 10.1038/modpathol.2009.29
19724680Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer.Neoplasia2009 SepLin Y-
20012321Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer.Cell Tissue Res2010 FebPrasad PDdoi: 10.1007/s00441-009-0902-y
21092460[Expression of SM22α and its relationship with lymph node metastasis in breast cancer].Zhonghua Yi Xue Za Zhi2010 Sep 28MA ZF-
17082327Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth.Mol Endocrinol2007 FebYang Z-
24657443Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.Biochem Biophys Res Commun2014 Apr 18Sahasrabuddhe NAdoi: 10.1016/j.bbrc.2014.03.017
28058861Downregulation of transgelin blocks interleukin-8 utilization and suppresses vasculogenic mimicry in breast cancer cells.Exp Biol Med (Maywood)2017 MarAikins ARdoi: 10.1177/1535370216685435
26934553Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes.Oncotarget2016 Apr 12Webber JPdoi: 10.18632/oncotarget.7716.
27270312Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.Oncotarget2016 Jul 12Xu Ldoi: 10.18632/oncotarget.9701.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr11117203117Missense_MutationNAI35T0.62
BLCAchr11117203447SilentnovelI107I0.74
BRCAchr11117204349Missense_MutationNAI199T0.33
BRCAchr11117204317SilentNAA188A0.11
CESCchr11117203164Missense_MutationnovelG51S0.3
COADchr11117203050Missense_Mutationrs774227686E13K0.21
COADchr11117204220Missense_Mutationrs138736412A156V0.37
COADchr11117202902Intronnovel0.12
COADchr11117203050Missense_Mutationrs774227686E13K0.15
GBMchr11117203376Missense_Mutationrs752292029P84S0.29
GBMchr11117203144Missense_Mutationrs757884018R44H0.41
HNSCchr11117204342Missense_MutationnovelR197W0.24
KIRPchr11117202965Intronnovel0.2
LAMLchr11117203001Splice_Sitenovel0.1
LGGchr11117202968Intronnovel0.53
LUSCchr11117203049Frame_Shift_DelnovelE13Kfs*230.24
LUSCchr11117203826Missense_MutationnovelS135C0.37
LUSCchr11117203809Missense_MutationnovelT129I0.23
OVchr11117203831SilentnovelL136L0.08
READchr11117203353Missense_Mutationrs780383343P76L0.24
READchr11117203083Missense_Mutationrs746670728E24K0.56
SKCMchr11117203793Missense_MutationnovelA124T0.31
SKCMchr111172030095'UTRrs7623222600.18
STADchr111172030075'UTRnovel0.3
STADchr11117203015Translation_Start_SitenovelM1?0.34
STADchr11117203124Silentrs140777664Q37Q0.32
STADchr11117203082SilentNAD23D0.26
UCECchr11117203067Silentrs757965263I18I0.38
UCECchr11117203448Missense_MutationNAK108E0.26
UCECchr11117204333Missense_Mutationrs772350872G194R0.24
UCECchr11117203329Missense_MutationNAS68I0.16
UCECchr11117203050Missense_Mutationrs774227686E13K0.43
UCECchr11117203049Silentrs536155414R12R0.43
UCECchr11117203306Splice_SitenovelX61_splice0.18
UCECchr11117204337Missense_Mutationrs747524780R195Q0.18
UCECchr11117203378SilentNAP84P0.14
UCECchr11117202996Splice_Regionnovel0.31
UCECchr11117203332Missense_MutationnovelL69P0.15
UCECchr11117204333Missense_Mutationrs772350872G194R0.34
UCSchr11117202915Intronnovel0.57

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.29170.00015732
BRCADEL0.46577.1709e-58
CESCDEL0.50851.0762e-32
CHOLDEL0.27780.048655
ESCAAMP0.09780.018342
HNSCDEL0.4081.8879e-21
KIRPDEL0.10072.839e-05
LIHCDEL0.20270.00030497
LUADDEL0.16674.2393e-06
PRADDEL0.08330.00026046
READDEL0.18790.054114
SARCDEL0.43971.8105e-09
SKCMDEL0.48233.6825e-28
STADDEL0.15658.3734e-05
TGCTDEL0.76670.21504
UCSDEL0.3750.086462
UVMDEL0.06250.023516

Survival Analysis
CancerP-value Q-value
STAD0.0043

Kaplan-Meier Survival Analysis

SARC0.0022

Kaplan-Meier Survival Analysis

MESO0.0014

Kaplan-Meier Survival Analysis

ACC0.0075

Kaplan-Meier Survival Analysis

LUSC0.011

Kaplan-Meier Survival Analysis

BRCA0.044

Kaplan-Meier Survival Analysis

KIRP0.00091

Kaplan-Meier Survival Analysis

COAD0.02

Kaplan-Meier Survival Analysis

BLCA0.0036

Kaplan-Meier Survival Analysis

LIHC0.043

Kaplan-Meier Survival Analysis

LGG0.019

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000149591 (Gene tree)
Gene ID
6876
Gene Symbol
TAGLN
Alias
SM22|WS3-10|TAGLN1|SMCC|DKFZp686P11128
Full Name
transgelin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
5,472 bases
Position
chr11:117,199,321-117,204,792
Accession
11553
RBP type
non-canonical RBP
Summary
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16310342Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells.Cell Signal2006 AugLien SC-
16135793PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins.Mol Cell Biol2005 SepKawai-Kowase K-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000529622TAGLN-204501-ENSP00000432380151 (aa)-H0YCU9
ENST00000525531TAGLN-2031048-ENSP00000432054201 (aa)-Q01995
ENST00000278968TAGLN-2011477-ENSP00000278968201 (aa)-Q01995
ENST00000392951TAGLN-202928-ENSP00000376678201 (aa)-Q01995
ENST00000533863TAGLN-2083298--- (aa)--
ENST00000530649TAGLN-2061227-ENSP00000431941201 (aa)-Q01995
ENST00000532870TAGLN-2072166-ENSP00000432282201 (aa)-Q01995
ENST00000529792TAGLN-205375-ENSP0000043186291 (aa)-E9PJ32
Gene Model
Click here to download ENSG00000149591's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000149591Triglycerides8E-926763881
ENSG00000149591Triglycerides2E-1021943158
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000149591rs7494944011117199645TBreast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy29059430[1.62-4.16]2.59GO_0009314|EFO_0000305|EFO_1000654
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149591's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000149591TAGLN10097.802ENSMUSG00000032085Tagln10098.165Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005515protein binding21044950.22245152.IPIFunction
GO:0005737cytoplasm-IEAComponent
GO:0007517muscle organ development9615232.TASProcess
GO:0030855epithelial cell differentiation21492153.IDAProcess
GO:0051015actin filament binding-IEAFunction
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