EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
11773051	Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.	J Biol Chem	2002 Mar 22	Shields JM	-
23331552	Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer.	Cancer Sci	2013 Apr	Zhou L	doi: 10.1111/cas.12107
24476357	Transgelins, cytoskeletal proteins implicated in different aspects of cancer development.	Expert Rev Proteomics	2014 Apr	Dvorakova M	doi: 10.1586/14789450.2014.860358
19848416	Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma.	J Proteome Res	2009 Dec	Rho JH	doi: 10.1021/pr900705r.
22245152	Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy.	FEBS Lett	2012 Feb 17	Kim TR	doi: 10.1016/j.febslet.2011.12.036
26847345	Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.	BMC Cancer	2016 Feb 4	Zhou HM	doi: 10.1186/s12885-016-2105-8.
20336793	Loss of SM22 is a characteristic signature of colon carcinogenesis and its restoration suppresses colon tumorigenicity in vivo and in vitro.	Cancer	2010 Jun 1	Yeo M	doi: 10.1002/cncr.25003.
19329940	Transgelin as a suppressor is associated with poor prognosis in colorectal carcinoma patients.	Mod Pathol	2009 Jun	Zhao L	doi: 10.1038/modpathol.2009.29
19724680	Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer.	Neoplasia	2009 Sep	Lin Y	-
20012321	Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer.	Cell Tissue Res	2010 Feb	Prasad PD	doi: 10.1007/s00441-009-0902-y
21092460	[Expression of SM22α and its relationship with lymph node metastasis in breast cancer].	Zhonghua Yi Xue Za Zhi	2010 Sep 28	MA ZF	-
17082327	Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth.	Mol Endocrinol	2007 Feb	Yang Z	-
24657443	Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.	Biochem Biophys Res Commun	2014 Apr 18	Sahasrabuddhe NA	doi: 10.1016/j.bbrc.2014.03.017
28058861	Downregulation of transgelin blocks interleukin-8 utilization and suppresses vasculogenic mimicry in breast cancer cells.	Exp Biol Med (Maywood)	2017 Mar	Aikins AR	doi: 10.1177/1535370216685435
26934553	Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes.	Oncotarget	2016 Apr 12	Webber JP	doi: 10.18632/oncotarget.7716.
27270312	Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.	Oncotarget	2016 Jul 12	Xu L	doi: 10.18632/oncotarget.9701.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	117203117	Missense_Mutation	NA	I35T	0.62
BLCA	chr11	117203447	Silent	novel	I107I	0.74
BRCA	chr11	117204349	Missense_Mutation	NA	I199T	0.33
BRCA	chr11	117204317	Silent	NA	A188A	0.11
CESC	chr11	117203164	Missense_Mutation	novel	G51S	0.3
COAD	chr11	117203050	Missense_Mutation	rs774227686	E13K	0.21
COAD	chr11	117204220	Missense_Mutation	rs138736412	A156V	0.37
COAD	chr11	117202902	Intron	novel		0.12
COAD	chr11	117203050	Missense_Mutation	rs774227686	E13K	0.15
GBM	chr11	117203376	Missense_Mutation	rs752292029	P84S	0.29
GBM	chr11	117203144	Missense_Mutation	rs757884018	R44H	0.41
HNSC	chr11	117204342	Missense_Mutation	novel	R197W	0.24
KIRP	chr11	117202965	Intron	novel		0.2
LAML	chr11	117203001	Splice_Site	novel		0.1
LGG	chr11	117202968	Intron	novel		0.53
LUSC	chr11	117203049	Frame_Shift_Del	novel	*E13Kfs23**	0.24
LUSC	chr11	117203826	Missense_Mutation	novel	S135C	0.37
LUSC	chr11	117203809	Missense_Mutation	novel	T129I	0.23
OV	chr11	117203831	Silent	novel	L136L	0.08
READ	chr11	117203353	Missense_Mutation	rs780383343	P76L	0.24
READ	chr11	117203083	Missense_Mutation	rs746670728	E24K	0.56
SKCM	chr11	117203793	Missense_Mutation	novel	A124T	0.31
SKCM	chr11	117203009	5'UTR	rs762322260		0.18
STAD	chr11	117203007	5'UTR	novel		0.3
STAD	chr11	117203015	Translation_Start_Site	novel	M1?	0.34
STAD	chr11	117203124	Silent	rs140777664	Q37Q	0.32
STAD	chr11	117203082	Silent	NA	D23D	0.26
UCEC	chr11	117203067	Silent	rs757965263	I18I	0.38
UCEC	chr11	117203448	Missense_Mutation	NA	K108E	0.26
UCEC	chr11	117204333	Missense_Mutation	rs772350872	G194R	0.24
UCEC	chr11	117203329	Missense_Mutation	NA	S68I	0.16
UCEC	chr11	117203050	Missense_Mutation	rs774227686	E13K	0.43
UCEC	chr11	117203049	Silent	rs536155414	R12R	0.43
UCEC	chr11	117203306	Splice_Site	novel	X61_splice	0.18
UCEC	chr11	117204337	Missense_Mutation	rs747524780	R195Q	0.18
UCEC	chr11	117203378	Silent	NA	P84P	0.14
UCEC	chr11	117202996	Splice_Region	novel		0.31
UCEC	chr11	117203332	Missense_Mutation	novel	L69P	0.15
UCEC	chr11	117204333	Missense_Mutation	rs772350872	G194R	0.34
UCS	chr11	117202915	Intron	novel		0.57

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2917	0.00015732
BRCA	DEL	0.4657	7.1709e-58
CESC	DEL	0.5085	1.0762e-32
CHOL	DEL	0.2778	0.048655
ESCA	AMP	0.0978	0.018342
HNSC	DEL	0.408	1.8879e-21
KIRP	DEL	0.1007	2.839e-05
LIHC	DEL	0.2027	0.00030497
LUAD	DEL	0.1667	4.2393e-06
PRAD	DEL	0.0833	0.00026046
READ	DEL	0.1879	0.054114
SARC	DEL	0.4397	1.8105e-09
SKCM	DEL	0.4823	3.6825e-28
STAD	DEL	0.1565	8.3734e-05
TGCT	DEL	0.7667	0.21504
UCS	DEL	0.375	0.086462
UVM	DEL	0.0625	0.023516

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0043	Kaplan-Meier Survival Analysis
SARC	0.0022	Kaplan-Meier Survival Analysis
MESO	0.0014	Kaplan-Meier Survival Analysis
ACC	0.0075	Kaplan-Meier Survival Analysis
LUSC	0.011	Kaplan-Meier Survival Analysis
BRCA	0.044	Kaplan-Meier Survival Analysis
KIRP	0.00091	Kaplan-Meier Survival Analysis
COAD	0.02	Kaplan-Meier Survival Analysis
BLCA	0.0036	Kaplan-Meier Survival Analysis
LIHC	0.043	Kaplan-Meier Survival Analysis
LGG	0.019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000149591 (Gene tree)
Gene ID: 6876
Gene Symbol: TAGLN
Alias: SM22|WS3-10|TAGLN1|SMCC|DKFZp686P11128
Full Name: transgelin
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 5,472 bases
Position: chr11:117,199,321-117,204,792
Accession: 11553
Summary: This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16310342	Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells.	Cell Signal	2006 Aug	Lien SC	-
16135793	PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins.	Mol Cell Biol	2005 Sep	Kawai-Kowase K	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000529622	TAGLN-204	501	-	ENSP00000432380	151 (aa)	-	H0YCU9
ENST00000525531	TAGLN-203	1048	-	ENSP00000432054	201 (aa)	-	Q01995
ENST00000278968	TAGLN-201	1477	-	ENSP00000278968	201 (aa)	-	Q01995
ENST00000392951	TAGLN-202	928	-	ENSP00000376678	201 (aa)	-	Q01995
ENST00000533863	TAGLN-208	3298	-	-	- (aa)	-	-
ENST00000530649	TAGLN-206	1227	-	ENSP00000431941	201 (aa)	-	Q01995
ENST00000532870	TAGLN-207	2166	-	ENSP00000432282	201 (aa)	-	Q01995
ENST00000529792	TAGLN-205	375	-	ENSP00000431862	91 (aa)	-	E9PJ32

Gene Model

Click here to download ENSG00000149591's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000149591	Triglycerides	8E-9	26763881
ENSG00000149591	Triglycerides	2E-10	21943158

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000149591	rs74949440	11	117199645	T	Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy	29059430	[1.62-4.16]	2.59	GO_0009314\|EFO_0000305\|EFO_1000654

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149591's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149591	TAGLN	100	97.802	ENSMUSG00000032085	Tagln	100	98.165	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21044950.22245152.	IPI	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0007517	muscle organ development	9615232.	TAS	Process
GO:0030855	epithelial cell differentiation	21492153.	IDA	Process
GO:0051015	actin filament binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.