EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25929737MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.BMC Cancer2015 May 2Zhou Cdoi: 10.1186/s12885-015-1366-y.
23158992[Expression of metastasis associated 1 family member 2 (MTA2) in gastric cancer and its relationship with transcription factor Sp1].Zhonghua Zhong Liu Za Zhi2012 AugZhou CFdoi: 10.3760/cma.j.issn.0253-3766.2012.08.007.
24468085P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.Biochem Biophys Res Commun2014 Feb 14Zhou Jdoi: 10.1016/j.bbrc.2014.01.062
28061540Metallothionein 2A an interactive protein linking phosphorylated FADD to NF-??B pathway leads to colorectal cancer formation.Chin Clin Oncol2016 DecMarikar FMdoi: 10.21037/cco.2016.11.03.
25081667Short-hairpin RNA-mediated MTA2 silencing inhibits human breast cancer cell line MDA-MB231 proliferation and metastasis.Asian Pac J Cancer Prev2014Lu J-
24969834Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression.Int J Oncol2014 SepUraki Sdoi: 10.3892/ijo.2014.2507
24010737MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1.Mol Cancer2013 Sep 8Zhou Cdoi: 10.1186/1476-4598-12-102.
25969565Metastasis-associated protein 2 (MTA2) promotes the metastasis of non-small-cell lung cancer through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin.Jpn J Clin Oncol2015 AugZhang Bdoi: 10.1093/jjco/hyv062

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1162596729Missense_MutationNAE264K0.32
BLCAchr1162597390Missense_MutationnovelL207V0.19
BLCAchr1162596799Missense_MutationnovelR240S0.08
BLCAchr1162598076Missense_MutationnovelE146D0.14
BLCAchr1162596313Missense_MutationNAD328H0.48
BLCAchr1162594601Missense_Mutationrs768452845R536Q0.3
BLCAchr1162595763Missense_MutationnovelR415W0.13
BLCAchr1162593931Missense_MutationnovelL651V0.98
BLCAchr1162595020Missense_MutationnovelL512V0.05
BRCAchr1162598129Frame_Shift_DelNAY129Tfs*330.46
BRCAchr1162600226Frame_Shift_DelNAC44Sfs*90.26
BRCAchr1162598592Missense_Mutationrs377599047R80C0.06
BRCAchr1162596056Missense_MutationNAM356I0.35
BRCAchr1162598076SilentNAE146E0.11
CESCchr1162600675Missense_MutationnovelE15K0.08
CESCchr11625937823'UTRnovel0.3
CESCchr1162596058Missense_MutationnovelM356V0.3
CESCchr11625937893'UTRnovel0.67
CESCchr1162595809Missense_MutationNAK399N0.43
COADchr1162594402Frame_Shift_DelNAA568Qfs*290.23
COADchr1162596316Missense_MutationnovelA327T0.12
COADchr1162595270Missense_MutationnovelA493T0.35
COADchr1162594987Missense_MutationnovelD523Y0.35
COADchr1162600234Missense_MutationnovelK41T0.31
COADchr1162598129Frame_Shift_DelNAY129Tfs*330.37
COADchr1162598374Missense_MutationNAT109A0.41
COADchr1162598523Missense_MutationNAR103W0.29
COADchr1162594406Missense_MutationnovelM565T0.31
COADchr1162596108Splice_SiteNAX339_splice0.23
COADchr1162594036Missense_MutationnovelL616I0.36
COADchr1162594631Missense_MutationnovelA526V0.17
COADchr1162594543Frame_Shift_InsNAI556Hfs*80.29
COADchr1162600217Missense_MutationNAR47W0.24
COADchr1162598035Missense_Mutationrs370573471R160H0.39
COADchr1162594032Missense_MutationNAR617Q0.29
COADchr1162598523Missense_MutationNAR103W0.23
DLBCchr1162600626Missense_MutationNAN31S0.18
ESCAchr1162595299Missense_MutationnovelY483C0.29
ESCAchr11625934403'UTRnovel0.29
ESCAchr1162595771Missense_MutationnovelG412E0.29
GBMchr1162595449Missense_MutationnovelS433T0.23
GBMchr1162595425Missense_MutationnovelA441V0.23
GBMchr1162598068Missense_MutationnovelV149G0.05
GBMchr1162596734Missense_MutationNAR262Q0.43
GBMchr1162594328Missense_MutationnovelA591V0.3
GBMchr1162598108Missense_Mutationrs202171761V136M0.46
GBMchr1162594583Missense_MutationnovelI542S0.26
GBMchr1162600639Missense_MutationnovelI27V0.12
HNSCchr1162598128Frame_Shift_InsnovelY129Lfs*60.14
HNSCchr1162598054Missense_MutationnovelQ154E0.35
HNSCchr1162594382Missense_MutationnovelS573C0.21
HNSCchr1162594565Missense_MutationnovelS548F0.19
HNSCchr1162596284Frame_Shift_DelnovelT338Pfs*190.42
HNSCchr1162596729Nonsense_MutationnovelE264*0.33
HNSCchr1162595398Missense_MutationnovelN450S0.49
HNSCchr1162596083SilentNAI347I0.27
KIRCchr1162595439SilentnovelP436P0.16
KIRCchr1162598608SilentNAG74G0.26
LAMLchr11625937563'UTRnovel0.1
LAMLchr1162598534Missense_MutationnovelA99G0.05
LAMLchr1162597714Splice_SitenovelX164_splice0.09
LAMLchr11625937563'UTRnovel0.29
LAMLchr1162596671Missense_Mutationrs760158792Y283C0.44
LAMLchr11625937563'UTRnovel0.25
LGGchr1162595441Frame_Shift_DelnovelS435Lfs*260.2
LGGchr1162594008Missense_MutationNAM625R0.07
LGGchr1162594289Missense_MutationnovelP604H0.3
LGGchr1162598039Missense_MutationnovelD159Y0.04
LGGchr1162596526Missense_MutationNAW297R0.26
LIHCchr1162600213Missense_MutationnovelR48H0.37
LIHCchr1162597366Nonsense_MutationnovelQ215*0.13
LIHCchr1162597367SilentnovelR214R0.14
LIHCchr11625937393'UTRnovel0.28
LUADchr1162600636Missense_MutationNAE28Q0.08
LUADchr1162595848Missense_MutationnovelM386I0.13
LUADchr1162594632Missense_MutationnovelA526S0.17
LUADchr1162596644Missense_MutationnovelQ292L0.31
LUADchr1162596815Frame_Shift_InsnovelM235Tfs*480.13
LUADchr1162595365Missense_MutationNAL461P0.1
LUSCchr1162595753Missense_MutationnovelT418M0.29
LUSCchr1162594354SilentNAG582G0.1
OVchr1162598360Missense_MutationNAE113D0.39
OVchr1162598360Missense_MutationnovelE113D0.22
OVchr1162595839SilentnovelR389R0.15
OVchr1162596826Splice_SiteNAX232_splice0.24
OVchr1162593939Missense_MutationnovelP648L0.06
OVchr11625937563'UTRnovel0.1
OVchr1162595855Missense_MutationNAP384R0.23
PRADchr1162593993Missense_MutationNAR630P0.4
READchr1162595479Missense_MutationnovelR423K0.15
READchr1162594273SilentnovelA609A0.26
READchr1162595431Missense_MutationnovelT439S0.17
SKCMchr1162593976Silentrs748199521L636L0.05
SKCMchr1162595066SilentNAS496S0.22
SKCMchr1162600223Missense_Mutationrs762827302L45F0.43
SKCMchr1162594605Missense_MutationNAP535S0.49
SKCMchr1162598057Missense_MutationNAY153H0.17
SKCMchr1162594525SilentNAA561A0.53
SKCMchr1162596083SilentNAI347I0.38
SKCMchr1162594382Missense_MutationNAS573F0.47
SKCMchr1162600625SilentNAN31N0.52
SKCMchr1162595023Missense_MutationNAP511S0.36
STADchr1162597633Silentrs141754862I190I0.08
STADchr1162593877Nonstop_MutationNA*669Rext*850.17
STADchr1162594994SilentNAI520I0.29
STADchr1162595427Silentrs780111889S440S0.37
STADchr1162596754Missense_MutationNAQ255H0.11
STADchr1162594399SilentNAG567G0.15
STADchr1162598129Frame_Shift_DelNAY129Tfs*330.28
TGCTchr1162600241Missense_MutationnovelE39Q0.29
THYMchr1162596648Missense_MutationnovelR291S0.08
UCECchr1162596505Missense_MutationNAV304F0.26
UCECchr1162593990Missense_Mutationrs777136719R631Q0.59
UCECchr1162594544Frame_Shift_DelNAG555Afs*40.45
UCECchr1162593888Missense_MutationNAV665D0.31
UCECchr1162595426Missense_Mutationrs769924403A441T0.47
UCECchr1162595843Missense_MutationnovelC388Y0.28
UCECchr1162598129Frame_Shift_DelNAY129Tfs*330.41
UCECchr1162594318SilentNAQ594Q0.39
UCECchr11625935633'UTRrs3683406810.39
UCECchr1162596029SilentnovelL365L0.3
UCECchr1162595753Missense_MutationnovelT418M0.31
UCECchr1162596715Nonsense_MutationnovelW268*0.51
UCECchr1162598574SilentNAR86R0.37
UCECchr11625936063'UTRnovel0.21
UCECchr1162595062Nonsense_MutationnovelR498*0.15
UCECchr1162597706Missense_MutationnovelS166Y0.5
UCECchr1162595752Splice_Regionrs150945923T418T0.39
UCECchr11625935703'UTRnovel0.37
UCECchr1162596490Missense_MutationnovelM309L0.3
UCECchr1162597357Missense_MutationnovelL218M0.22
UCECchr1162595062Nonsense_MutationnovelR498*0.12
UCECchr1162595309Nonsense_MutationNAR480*0.23
UCECchr11625938293'UTRnovel0.39
UCECchr1162595305Missense_Mutationrs746902489R481Q0.24
UCECchr1162595284Missense_MutationNAA488V0.24
UCECchr11625935893'UTRnovel0.45
UCSchr1162596648Missense_Mutationrs759893426R291C0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.16850.018342
TGCTDEL0.70670.21504

Survival Analysis
CancerP-value Q-value
KIRC0.0069

Kaplan-Meier Survival Analysis

STAD0.0037

Kaplan-Meier Survival Analysis

SARC0.016

Kaplan-Meier Survival Analysis

MESO0.0082

Kaplan-Meier Survival Analysis

ACC0.00053

Kaplan-Meier Survival Analysis

BRCA0.006

Kaplan-Meier Survival Analysis

ESCA0.027

Kaplan-Meier Survival Analysis

KIRP0.039

Kaplan-Meier Survival Analysis

PCPG0.04

Kaplan-Meier Survival Analysis

CESC0.016

Kaplan-Meier Survival Analysis

LAML0.0001

Kaplan-Meier Survival Analysis

LIHC0.00071

Kaplan-Meier Survival Analysis

OV0.012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000149480 (Gene tree)
Gene ID
9219
Gene Symbol
MTA2
Alias
MTA1-L1|MTA1L1
Full Name
metastasis associated 1 family member 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
8,638 bases
Position
chr11:62,593,203-62,601,840
Accession
7411
RBP type
non-canonical RBP
Summary
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000524902MTA2-2022577-ENSP00000431346495 (aa)-O94776
ENST00000527204MTA2-2042265-ENSP00000431797495 (aa)-O94776
ENST00000526844MTA2-203627--- (aa)--
ENST00000531261MTA2-206563--- (aa)--
ENST00000278823MTA2-2013058-ENSP00000278823668 (aa)-O94776
ENST00000531179MTA2-205625--- (aa)--
ENST00000532239MTA2-207532--- (aa)--
Gene Model
Click here to download ENSG00000149480's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149480's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000149480MTA210059.275ENSMUSG00000021144Mta110059.610Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000118histone deacetylase complex10444591.TASComponent
GO:0000122negative regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0000790nuclear chromatin16217013.HDAComponent
GO:0000976transcription regulatory region sequence-specific DNA binding16217013.IDAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0001085RNA polymerase II transcription factor binding15920471.IPIFunction
GO:0001103RNA polymerase II repressing transcription factor binding21873635.IBAFunction
GO:0001103RNA polymerase II repressing transcription factor binding22926524.IPIFunction
GO:0003713transcription coactivator activity21873635.IBAFunction
GO:0003714transcription corepressor activity21873635.IBAFunction
GO:0004407histone deacetylase activity-IEAFunction
GO:0005515protein binding17956988.18451879.19703393.20127688.21258344.23752268.25150861.26028330.26496610.27705803.28179136.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005667transcription factor complex15920471.IDAComponent
GO:0006306DNA methylation-IEAProcess
GO:0006333chromatin assembly or disassembly10444591.TASProcess
GO:0008270zinc ion binding-IEAFunction
GO:0010762regulation of fibroblast migration-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016575histone deacetylation21873635.IBAProcess
GO:0016581NuRD complex21873635.IBAComponent
GO:0016581NuRD complex19644445.22926524.IDAComponent
GO:0031492nucleosomal DNA binding16217013.HDAFunction
GO:0032991protein-containing complex16217013.HDAComponent
GO:0042826histone deacetylase binding21873635.IBAFunction
GO:0043044ATP-dependent chromatin remodeling16217013.HDAProcess
GO:0045944positive regulation of transcription by RNA polymerase II-IEAProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
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