EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21091576Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility.Brain Pathol2011 JulPetermann Adoi: 10.1111/j.1750-3639.2010.00464.x
15231692Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo.Carcinogenesis2004 NovTrapasso F-
19836242An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.Curr Biol2009 Nov 17Tarcic Gdoi: 10.1016/j.cub.2009.09.048.
16778204The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.Cancer Res2006 Jun 15Iervolino A-
28052032A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.Oncotarget2017 Feb 7Bilotta Adoi: 10.18632/oncotarget.14350.
21036128Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer.Gastroenterology2010 DecVenkatachalam Rdoi: 10.1053/j.gastro.2010.08.063
16000320Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer.Hum Mol Genet2005 Aug 15Lesueur F-
25412306Characterization of novel markers of senescence and their prognostic potential in cancer.Cell Death Dis2014 Nov 20Althubiti Mdoi: 10.1038/cddis.2014.489.
28316102Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer.J Cell Biochem2017 OctZhang XFdoi: 10.1002/jcb.25995
30661225Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk.J Appl Genet2019 FebLaczmanska Idoi: 10.1007/s13353-019-00481-3

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1148139619Silentrs751724128A762A0.05
BLCAchr1148155840Missense_MutationnovelS1090L0.08
BLCAchr1148125033Missense_MutationnovelV314M0.22
BLCAchr1148127841SilentnovelI385I0.28
BLCAchr1148137030Missense_MutationNAV634A0.24
BLCAchr1148155856Missense_Mutationrs756360727I1095M0.36
BLCAchr1148130496SilentNAV465V0.25
BLCAchr1148167307Missense_MutationnovelY1320F0.44
BLCAchr1148167221Silentrs540802430L1291L0.25
BLCAchr1148112863Missense_MutationNAQ78E0.29
BLCAchr1148139772SilentNAI813I0.29
BLCAchr1148125009Missense_MutationNAA306T0.07
BLCAchr1148137071Missense_MutationnovelF648V0.21
BLCAchr1148163547Silentrs2229704I1216I0.29
BLCAchr1148123782SilentnovelL262L0.31
BRCAchr1148143007Silentrs147493496H844H0.04
BRCAchr1148153884Missense_MutationnovelP1076L0.09
BRCAchr1148145067Missense_MutationNAE952K0.46
BRCAchr1148127890Missense_MutationNAH402Y0.13
BRCAchr1148131631Intronnovel0.12
BRCAchr1148142928Missense_MutationNAP818R0.26
BRCAchr1148125052Missense_MutationNAS320F0.15
BRCAchr1148153866Missense_MutationNAR1070H0.16
BRCAchr1148121173Frame_Shift_DelnovelG175Efs*20.17
BRCAchr1148143025SilentNAY850Y0.34
CESCchr1148130481SilentnovelF460F0.12
CESCchr1148136217Silentrs369760760P598P0.42
CESCchr1148139676Silentrs768525817T781T0.62
CESCchr1148164381Missense_MutationnovelA1241T0.34
CESCchr1148164509SilentNAQ1283Q0.4
CESCchr1148136241Missense_MutationNAI606M0.29
CESCchr1148160028Missense_MutationnovelI1179M0.26
COADchr1148160025SilentNAT1178T0.18
COADchr1148128017Missense_Mutationrs761076895T444M0.19
COADchr1148121245Missense_MutationnovelR199G0.37
COADchr1148145049Missense_MutationnovelG946R0.26
COADchr1148125009Missense_MutationNAA306T0.18
COADchr1148155865SilentNAN1098N0.3
COADchr1148136217Silentrs369760760P598P0.27
COADchr1148112926Missense_MutationnovelP99S0.16
COADchr1148136111Missense_Mutationrs767845396P563L0.33
COADchr11481673993'UTRrs7528238470.08
COADchr1148167245SilentnovelV1299V0.05
COADchr1148121073SilentnovelS141S0.34
COADchr1148146892Silentrs752139572A976A0.06
COADchr11481676023'UTRnovel0.5
COADchr1148136074Missense_Mutationrs769547786V551I0.09
COADchr1148139759Missense_MutationNAC809Y0.4
COADchr1148123757Missense_Mutationrs148218497R254I0.23
COADchr1148137124SilentNAG665G0.29
COADchr1148136073Silentrs148782546Y550Y0.36
COADchr1148156054Missense_Mutationrs536396969R1125C0.28
COADchr1148139619Silentrs751724128A762A0.29
COADchr1148130650Missense_MutationNAF517L0.43
ESCAchr11481674023'UTRrs7641992760.48
ESCAchr1148110077Splice_SitenovelX39_splice0.43
ESCAchr1148139568Silentrs755561818G745G0.16
GBMchr1148137181Frame_Shift_DelnovelT685Lfs*30.03
GBMchr1148137137Missense_Mutationrs200255695A670T0.21
GBMchr1148144767Nonsense_MutationnovelE890*0.47
GBMchr1148155800Splice_SitenovelX1077_splice0.22
GBMchr1148127874Missense_MutationnovelN396K0.26
GBMchr1148145061Frame_Shift_DelnovelA951Lfs*380.09
GBMchr1148123812Silentrs770215254P272P0.14
GBMchr1148163566Missense_Mutationrs746784211R1223C0.23
GBMchr1148112844Missense_MutationnovelQ71H0.27
GBMchr1148139676Silentrs768525817T781T0.07
GBMchr1148156092Missense_MutationnovelM1137I0.06
HNSCchr1148146944Missense_MutationnovelI994V0.47
HNSCchr1148136106Missense_MutationnovelK561N0.19
HNSCchr1148145095Nonsense_MutationnovelS961*0.08
HNSCchr1148159940Missense_MutationnovelE1150V0.1
HNSCchr1148137027Missense_MutationnovelD633A0.11
HNSCchr1148146873Splice_Regionnovel0.27
HNSCchr1148127832Silentrs145270865L382L0.26
HNSCchr1148123819Missense_MutationnovelL275V0.29
HNSCchr1148144838SilentnovelT913T0.21
HNSCchr1148160038Missense_MutationnovelT1183S0.64
KIRCchr1148167351Missense_MutationnovelY1335N0.34
KIRCchr1148144689Missense_MutationNAA864T0.1
KIRCchr1148130549Missense_MutationNAQ483R0.42
KIRCchr1148121225Missense_Mutationrs61737868N192S0.38
KIRCchr1148144716Missense_MutationNAD873Y0.28
KIRCchr1148131677Intronnovel0.3
KIRPchr1148160034Missense_MutationNAD1181E0.38
KIRPchr1148121209Missense_MutationNAT187A0.29
KIRPchr1148164440Missense_MutationnovelE1260D0.06
KIRPchr1148121176Missense_MutationNAL176V0.41
KIRPchr1148121000Splice_Regionnovel0.26
KIRPchr1148127951Missense_MutationNAP422L0.34
LAMLchr1148164401SilentnovelG1247G0.04
LAMLchr1148163589SilentnovelP1230P0.07
LAMLchr1148137172Silentrs140686417D681D0.48
LAMLchr1148121201Missense_MutationnovelF184S0.11
LAMLchr1148112789Frame_Shift_DelnovelT53Kfs*60.05
LAMLchr1148112790SilentnovelT53T0.06
LGGchr1148127978Missense_Mutationrs561061051N431S0.45
LGGchr1148130638Missense_MutationNAT513A0.48
LGGchr1148112803Missense_MutationnovelI58V0.45
LGGchr1148159963Missense_MutationnovelA1158T0.05
LIHCchr1148163619Splice_SiteNAX1240_splice0.54
LIHCchr1148121027Missense_MutationnovelK126R0.45
LIHCchr1148167283Missense_MutationnovelQ1312R0.2
LUADchr1148159990Missense_MutationNAA1167S0.32
LUADchr1148136259Silentrs747722144H612H0.06
LUADchr1148164453Missense_MutationNAV1265L0.42
LUADchr1148137129Missense_MutationNAS667F0.08
LUADchr1148121152Nonsense_MutationnovelQ168*0.21
LUADchr1148156055Missense_MutationnovelR1125L0.26
LUADchr1148112979Frame_Shift_DelnovelT117Wfs*70.09
LUADchr1148124992Missense_MutationNAR300L0.14
LUADchr1148164474Missense_MutationnovelY1272H0.14
LUADchr1148163608Missense_MutationnovelV1237L0.41
LUADchr1148164430Missense_MutationNAY1257C0.22
LUADchr1148125093Missense_MutationNAG334W0.19
LUADchr1148156087Missense_MutationnovelI1136V0.07
LUSCchr1148137063Missense_MutationnovelW645L0.13
LUSCchr11481673783'UTRnovel0.32
LUSCchr1148137128Missense_MutationNAS667P0.36
LUSCchr1148123637Missense_MutationNAR214L0.74
LUSCchr1148142917Splice_SiteNAX815_splice0.35
LUSCchr1148136076SilentnovelV551V0.05
LUSCchr1148144757SilentnovelL886L0.28
LUSCchr1148137079Silentrs763072219D650D0.2
LUSCchr1148136181SilentnovelT586T0.13
LUSCchr1148125040Missense_MutationNAP316L0.3
LUSCchr1148144855Missense_MutationNAN919S0.39
LUSCchr1148128021SilentNAP445P0.15
LUSCchr1148125048Missense_MutationnovelP319S0.28
LUSCchr1148139631Missense_MutationnovelE766D0.29
LUSCchr11481673893'UTRnovel0.17
LUSCchr1148136053Missense_MutationnovelF544L0.42
LUSCchr1148139485Splice_SitenovelX718_splice0.37
LUSCchr1148137002Splice_SitenovelX625_splice0.15
LUSCchr1148144821Missense_MutationnovelV908F0.26
LUSCchr1148124982Nonsense_MutationnovelE297*0.15
OVchr1148164397Missense_MutationnovelT1246K0.04
OVchr11481673733'UTRnovel0.17
OVchr1148125105Missense_MutationNAG338S0.25
OVchr1148142922Missense_MutationnovelP816L0.13
OVchr1148145088Missense_MutationnovelR959G0.09
OVchr1148137083Missense_MutationnovelS652P0.06
OVchr1148144806Missense_MutationnovelK903Q0.03
OVchr11481674613'UTRnovel0.12
OVchr1148136126Missense_MutationnovelE568G0.07
OVchr1148146940SilentNAG992G0.09
OVchr1148136133SilentnovelV570V0.07
PAADchr1148127886SilentnovelK400K0.04
PAADchr1148139615Missense_Mutationrs763253994N761S0.17
PRADchr1148139586Silentrs748999792E751E0.08
PRADchr1148123685Missense_MutationnovelG230D0.38
READchr1148150117SilentNAE1024E0.27
READchr1148121144Missense_MutationnovelV165A0.05
READchr1148123837Missense_MutationnovelK281Q0.18
READchr1148139619Silentrs751724128A762A0.38
READchr1148150181Missense_Mutationrs765457377E1046K0.41
READchr1148156032SilentNAP1117P0.25
SARCchr1148155811SilentnovelS1080S0.26
SKCMchr1148130474Missense_MutationNAS458F0.25
SKCMchr1148144857Missense_MutationNAG920W0.26
SKCMchr1148136136SilentNAY571Y0.28
SKCMchr1148130481SilentnovelF460F0.17
SKCMchr1148139669Missense_MutationNAE779V0.24
SKCMchr1148164484Missense_MutationNAR1275Q0.11
SKCMchr1148155996SilentNAS1105S0.38
SKCMchr1148136216Missense_Mutationrs377252468P598L0.44
SKCMchr1148136262SilentNAV613V0.37
SKCMchr1148155982Splice_Regionnovel0.11
SKCMchr1148137074Missense_MutationNAD649N0.14
SKCMchr1148142921Missense_MutationNAP816S0.32
SKCMchr1148112865SilentnovelQ78Q0.18
SKCMchr1148139502SilentnovelA723A0.11
SKCMchr1148123735Missense_MutationNAE247K0.41
SKCMchr1148136274SilentnovelP617P0.31
SKCMchr1148127950Missense_MutationNAP422S0.39
SKCMchr1148125103Missense_MutationNAP337L0.26
SKCMchr1148163600Missense_MutationNAP1234L0.2
SKCMchr1148146939Missense_MutationNAG992D0.19
SKCMchr1148112832SilentnovelS67S0.41
SKCMchr1148112911Missense_Mutationrs759543022D94N0.55
SKCMchr1148142918Splice_SitenovelX817_splice0.41
SKCMchr1148124993SilentnovelR300R0.48
SKCMchr1148136137Missense_MutationNAH572Y0.25
SKCMchr1148167323SilentnovelP1325P0.33
SKCMchr1148123769Missense_MutationNAN258S0.45
SKCMchr1148156066Nonsense_MutationNAE1129*0.43
STADchr1148155800Splice_SiteNAX1077_splice0.11
STADchr1148112824Missense_MutationNAA65T0.09
STADchr1148144716Missense_Mutationrs755218393D873N0.18
STADchr1148127799Silentrs780863107D371D0.27
STADchr1148125009Missense_MutationNAA306T0.09
STADchr1148125009Missense_MutationNAA306T0.3
STADchr1148130496SilentNAV465V0.23
STADchr1148145109Missense_MutationnovelL966V0.4
STADchr1148139741Frame_Shift_DelnovelT805Pfs*290.22
STADchr1148150113Missense_MutationNAV1023A0.06
STADchr1148150095Splice_SiteNAX1017_splice0.44
STADchr1148167319Missense_Mutationrs199803858A1324V0.24
STADchr11481674133'UTRrs1910126500.37
STADchr1148155822Missense_MutationnovelL1084R0.3
STADchr1148110067Missense_MutationNAA36T0.25
STADchr1148125013Missense_MutationNAP307H0.09
STADchr1148145081SilentNAS956S0.08
STADchr1148163614Missense_MutationNAC1239R0.1
STADchr1148139561Missense_MutationNAP743H0.22
STADchr1148127898Frame_Shift_DelnovelE406Rfs*330.35
STADchr1148156054Missense_Mutationrs536396969R1125C0.39
STADchr1148156055Missense_Mutationrs374260795R1125H0.05
STADchr1148123621Missense_MutationNAP209T0.15
STADchr1148136264Frame_Shift_DelNAD616Tfs*190.15
STADchr1148136182Missense_MutationNAY587H0.27
STADchr1148167350SilentNAG1334G0.34
STADchr1148144820Silentrs532049445D907D0.25
STADchr1148137128Missense_MutationNAS667P0.36
STADchr1148137030Missense_MutationNAV634A0.12
STADchr1148125009Missense_MutationNAA306T0.1
STADchr1148127865Silentrs748897376S393S0.3
STADchr1148123625Missense_MutationNAV210A0.21
STADchr1148123696Missense_MutationNAA234T0.33
STADchr1148130504Missense_Mutationrs140690947T468M0.14
STADchr1148123730Missense_Mutationrs753741250S245N0.35
THCAchr1148125156Missense_MutationNAG355R0.14
UCECchr1148156032SilentNAP1117P0.28
UCECchr1148123617Silentrs137863628P207P0.27
UCECchr1148139515Missense_Mutationrs181029182E728K0.28
UCECchr1148163601Silentrs753492303P1234P0.35
UCECchr1148112811Missense_MutationnovelQ60H0.27
UCECchr1148136172SilentnovelH583H0.12
UCECchr1148137261Missense_MutationnovelG711D0.24
UCECchr1148144716Missense_Mutationrs755218393D873N0.56
UCECchr1148145089Missense_Mutationrs183923997R959H0.29
UCECchr1148156018Missense_MutationnovelQ1113E0.19
UCECchr1148167357Missense_Mutationrs200505007A1337T0.41
UCECchr1148150140Missense_MutationnovelK1032T0.49
UCECchr1148142940Missense_MutationnovelS822F0.36
UCECchr1148139605Missense_MutationNAA758T0.46
UCECchr1148124974Missense_MutationnovelS294I0.4
UCECchr1148139667Silentrs771594321T778T0.39
UCECchr1148153866Missense_MutationNAR1070H0.22
UCECchr1148160004Missense_MutationnovelE1171D0.35
UCECchr1148139697Silentrs774412163S788S0.43
UCECchr1148160044Missense_MutationNAK1185E0.47
UCECchr1148121083Missense_Mutationrs766468331A145T0.12
UCECchr1148130585Missense_MutationNAR495Q0.33
UCECchr1148163527Missense_Mutationrs777452594D1210N0.21
UCECchr11481674023'UTRrs7641992760.19
UCECchr1148164484Missense_MutationNAR1275Q0.39
UCECchr11481674283'UTRrs734520040.58
UCECchr1148125101Missense_MutationNAE336D0.43
UCECchr1148137173Missense_Mutationrs373520236A682T0.42
UCECchr1148160030Missense_MutationNAR1180I0.37
UCECchr1148131514Intronnovel0.4
UCECchr1148153862Missense_MutationnovelN1069H0.33
UCECchr1148137173Missense_Mutationrs373520236A682T0.13
UCECchr1148124986Missense_MutationnovelR298K0.25
UCECchr1148136289SilentnovelQ622Q0.29
UCECchr1148145117Missense_MutationnovelQ968H0.42
UCECchr11481674343'UTRnovel0.22
UCECchr1148123696Missense_MutationNAA234T0.4
UCECchr1148127865Silentrs748897376S393S0.49
UCECchr1148137080Missense_Mutationrs184451413A651T0.32
UCECchr1148139668Missense_MutationnovelE779K0.4
UCECchr1148145097Missense_MutationnovelD962Y0.52
UCECchr1148160002Nonsense_MutationnovelE1171*0.42
UCECchr1148127859Silentrs147639990N391N0.37
UCECchr1148139515Missense_Mutationrs181029182E728K0.38
UCECchr1148121065Missense_MutationnovelW139R0.1
UCECchr1148136288Missense_MutationnovelQ622R0.2
UCECchr1148144762Missense_MutationnovelR888K0.44
UCECchr1148139514Silentrs559753032C727C0.45
UCECchr1148150130In_Frame_InsnovelK1032_Q1033insSVFIGRRVEHDKEANFKK0.02
UCECchr1148163593Missense_Mutationrs549361841E1232K0.12
UCECchr1148153864SilentnovelN1069N0.27
UCECchr1148164484Missense_MutationNAR1275Q0.29
UCECchr1148125153Nonsense_MutationNAE354*0.48
UCECchr1148139509Missense_Mutationrs374727162D726N0.42
UCECchr1148123705Missense_Mutationrs374139660R237W0.33
UCECchr1148127904Missense_MutationnovelE406D0.38
UCECchr1148137217Missense_MutationnovelE696D0.44
UCECchr1148131512Intronnovel0.08
UCECchr1148163567Missense_Mutationrs144070412R1223H0.33
UCECchr1148139676Silentrs768525817T781T0.33
UCECchr1148163476Missense_MutationnovelH1193Y0.04
UCECchr1148121015Missense_MutationnovelV122A0.27
UCECchr1148167319Missense_Mutationrs199803858A1324V0.33
UCECchr11481674233'UTRnovel0.6
UCECchr1148131579Intronnovel0.31
UCECchr1148156055Missense_Mutationrs374260795R1125H0.14
UCECchr1148164484Missense_MutationNAR1275Q0.22
UCECchr1148163566Missense_Mutationrs746784211R1223C0.29
UCECchr1148159994Missense_MutationNAM1168T0.54
UCECchr1148121118Missense_MutationNAK156N0.28
UCECchr1148167309Nonsense_MutationnovelE1321*0.25
UCECchr1148144748SilentnovelV883V0.42
UCECchr1148136076SilentNAV551V0.34
UCECchr1148139736Frame_Shift_InsnovelA802Efs*260.1
UCECchr1148139738Missense_MutationnovelA802V0.08
UCECchr1148125009Missense_MutationNAA306T0.51
UCECchr1148125161Missense_MutationnovelQ356H0.25
UCECchr1148136186Missense_MutationnovelD588A0.18
UCECchr1148137080Missense_Mutationrs184451413A651T0.45
UCECchr1148139671Missense_MutationnovelV780F0.23
UCECchr1148156029SilentnovelL1116L0.17
UCECchr1148144705Missense_MutationnovelY869S0.17
UCECchr1148153866Missense_MutationNAR1070H0.54
UCECchr1148125169Missense_MutationNAA359V0.23
UCECchr1148127779Splice_SiteNAX365_splice0.26
UCECchr1148112808Silentrs146294071T59T0.39
UCECchr1148124986Missense_MutationnovelR298I0.48
UCECchr1148130550SilentnovelQ483Q0.65
UCECchr1148136206Missense_MutationnovelG595S0.5
UCECchr1148130621Missense_Mutationrs374658783G507D0.42

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.15220.018342
PRADDEL0.05690.0050014
TGCTDEL0.61330.21504

Survival Analysis
CancerP-value Q-value
THYM0.0021

Kaplan-Meier Survival Analysis

KIRC0.025

Kaplan-Meier Survival Analysis

STAD0.0085

Kaplan-Meier Survival Analysis

HNSC0.048

Kaplan-Meier Survival Analysis

PCPG0.025

Kaplan-Meier Survival Analysis

GBM0.05

Kaplan-Meier Survival Analysis

CHOL0.012

Kaplan-Meier Survival Analysis

Drugs

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Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000149177 (Gene tree)
Gene ID
5795
Gene Symbol
PTPRJ
Alias
DEP1|HPTPeta|CD148
Full Name
protein tyrosine phosphatase receptor type J
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
190,285 bases
Position
chr11:47,980,558-48,170,842
Accession
9673
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000527952PTPRJ-205626-ENSP00000435618146 (aa)-E9PJ83
ENST00000527026PTPRJ-204555--- (aa)--
ENST00000526550PTPRJ-203571--- (aa)--
ENST00000418331PTPRJ-2015122XM_017018083ENSP000004000101337 (aa)XP_016873572Q12913
ENST00000615445PTPRJ-2084773-ENSP000004793421342 (aa)-A0A087WVC6
ENST00000613246PTPRJ-2077851-ENSP000004779331338 (aa)-A0A087WTK0
ENST00000534219PTPRJ-206546-ENSP00000432686120 (aa)-E9PPH3
ENST00000440289PTPRJ-2023158-ENSP00000409733539 (aa)-Q12913
Gene Model
Click here to download ENSG00000149177's gene model file
Pathways
Pathway IDPathway NameSource
hsa04520Adherens junctionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000149177Cholesterol, HDL9.17e-00519060910
ENSG00000149177Cholesterol, HDL1.347e-00619060910
ENSG00000149177Platelet Function Tests5.2800000E-006-
ENSG00000149177Autistic Disorder5.0689000E-005-
ENSG00000149177Autistic Disorder5.0689000E-005-
ENSG00000149177Autistic Disorder4.0662000E-005-
ENSG00000149177Autistic Disorder1.6021000E-005-
ENSG00000149177Autistic Disorder6.4663000E-006-
ENSG00000149177Autistic Disorder1.0107000E-005-
ENSG00000149177Autistic Disorder7.9038000E-006-
ENSG00000149177Autistic Disorder2.4829000E-005-
ENSG000001491773-hydroxy-1-methylpropylmercapturic acid3E-626053186
ENSG00000149177Smoking3E-626053186
ENSG00000149177Precursor Cell Lymphoblastic Leukemia-Lymphoma1E-622076464
ENSG00000149177Body Height7E-1223563607
ENSG00000149177Body Height4E-1220881960
ENSG00000149177Precursor Cell Lymphoblastic Leukemia-Lymphoma5E-722076464
ENSG00000149177Thrombin6E-1124357727
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000149177rs47528051147996803AIntraocular pressure29617998[0.12-0.18] unit decrease0.152EFO_0004695
ENSG00000149177rs108388011148076728AHeight20881960[NR] unit decrease0.027EFO_0004339
ENSG00000149177rs39428521148093537CAcute lymphoblastic leukemia (childhood)22076464EFO_0000220
ENSG00000149177rs39428521148093537TAcute lymphoblastic leukemia (childhood)22076464[1.12-1.47]1.2987013EFO_0000220
ENSG00000149177rs108388091148152460?3-hydroxy-1-methylpropylmercapturic acid levels in smokers26053186[NR] unit increase0.3947EFO_0004318|EFO_0007015
ENSG00000149177rs108387981148069751THeight23563607[NR]1.16EFO_0004339
ENSG00000149177rs1383152851148042642AThrombin generation potential phenotypes24357727[25.11-46.51] nM increase35.81EFO_0005538
ENSG00000149177rs71234361147991932?Intraocular pressure30054594[0.13-0.19] unit increase0.1574EFO_0004695
ENSG00000149177rs728997411148057294?General cognitive ability29844566z-score decrease4.661EFO_0004337
ENSG00000149177rs125745001148126898ABlood protein levels30072576[0.12-0.28] unit decrease0.199EFO_0007937
ENSG00000149177rs71234361147991932GIntraocular pressure29785010[0.14-0.2] unit decrease0.172EFO_0004695
ENSG00000149177rs71175161148076944?Heel bone mineral density30048462[0.016-0.027] unit decrease0.0215687EFO_0009270
ENSG00000149177rs71175161148076944THeel bone mineral density30598549[0.013-0.024] unit decrease0.0185212EFO_0009270
ENSG00000149177rs1853931371148071804?Eosinophil counts30595370EFO_0004842
ENSG00000149177rs71175161148076944?Heel bone mineral density30595370EFO_0009270
ENSG00000149177rs116021801148140901CSleep duration30846698unit increase0.918EFO_0005271
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149177's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001772immunological synapse12913111.IDAComponent
GO:0004725protein tyrosine phosphatase activity9531590.10821867.12913111.18348712.18936167.19332538.IDAFunction
GO:0004725protein tyrosine phosphatase activity9780142.12475979.IMPFunction
GO:0004725protein tyrosine phosphatase activity-TASFunction
GO:0005161platelet-derived growth factor receptor binding10821867.IPIFunction
GO:0005515protein binding10821867.12370829.12475979.12771128.16893970.18936167.19167335.19494114.23650535.IPIFunction
GO:0005886plasma membrane9531590.18348712.19836242.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005887integral component of plasma membrane7937872.TASComponent
GO:0005911cell-cell junction12370829.19332538.IDAComponent
GO:0008013beta-catenin binding12370829.IPIFunction
GO:0008285negative regulation of cell proliferation14709717.16682945.IDAProcess
GO:0009986cell surface12913111.IDAComponent
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathway14709717.IDAProcess
GO:0016791phosphatase activity12062403.12370829.19494114.IDAFunction
GO:0016791phosphatase activity11259588.19836242.IMPFunction
GO:0019901protein kinase binding19332538.IPIFunction
GO:0030155regulation of cell adhesion12370829.IMPProcess
GO:0030183B cell differentiation-ISSProcess
GO:0030308negative regulation of cell growth14709717.IDAProcess
GO:0030336negative regulation of cell migration16682945.IDAProcess
GO:0032587ruffle membrane-IEAComponent
GO:0032760positive regulation of tumor necrosis factor production-ISSProcess
GO:0035335peptidyl-tyrosine dephosphorylation9531590.10821867.12913111.18348712.18936167.19332538.IDAProcess
GO:0035335peptidyl-tyrosine dephosphorylation9780142.12475979.IMPProcess
GO:0035579specific granule membrane-TASComponent
GO:0035584calcium-mediated signaling using intracellular calcium source-ISSProcess
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway19836242.IMPProcess
GO:0043116negative regulation of vascular permeability19332538.IDAProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0043407negative regulation of MAP kinase activity19494114.IDAProcess
GO:0043410positive regulation of MAPK cascade-ISSProcess
GO:0045295gamma-catenin binding12370829.IPIFunction
GO:0045785positive regulation of cell adhesion21091576.IMPProcess
GO:0048008platelet-derived growth factor receptor signaling pathway21091576.IMPProcess
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-ISSProcess
GO:0050852T cell receptor signaling pathway-TASProcess
GO:0050860negative regulation of T cell receptor signaling pathway12913111.IDAProcess
GO:0050860negative regulation of T cell receptor signaling pathway9780142.11259588.IMPProcess
GO:0050918positive chemotaxis14709717.IDAProcess
GO:0051019mitogen-activated protein kinase binding19494114.IPIFunction
GO:0051894positive regulation of focal adhesion assembly21091576.IMPProcess
GO:0051897positive regulation of protein kinase B signaling18936167.IMPProcess
GO:0051898negative regulation of protein kinase B signaling19922411.IMPProcess
GO:0060242contact inhibition7937872.NASProcess
GO:0070062extracellular exosome19056867.23533145.HDAComponent
GO:0070097delta-catenin binding12370829.19332538.IPIFunction
GO:1905451positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis-ISSProcess
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