EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1050814013SilentnovelG397G0.34
BLCAchr1050841869Missense_MutationNAE120K0.28
BLCAchr1050859858Missense_MutationNAG28A0.24
BLCAchr1050836119Missense_MutationnovelE187K0.07DND1_DSRM
BLCAchr1050810018SilentNAL503L0.31
BLCAchr1050813960Missense_MutationNAG415E0.32
BLCAchr1050811086SilentnovelL480L0.17
BRCAchr1050850688Intronnovel0.08
BRCAchr1050813906Frame_Shift_DelnovelP433Qfs*20.11
BRCAchr1050836177SilentNAI167I0.17
BRCAchr1050828193Missense_MutationNAR236I0.57
BRCAchr1050836094Missense_Mutationrs748398755A195V0.35DND1_DSRM
BRCAchr1050813932Missense_MutationnovelD424E0.39
BRCAchr1050836295Missense_MutationNAG128E0.17
BRCAchr1050836181Missense_MutationnovelV166D0.06DND1_DSRM
BRCAchr1050841872Missense_MutationNAY119N0.33
BRCAchr1050850788Intronnovel0.26
CESCchr1050820643Frame_Shift_InsnovelV259Efs*50.14
CESCchr1050820645SilentnovelA258A0.14
CESCchr1050806874Missense_MutationnovelA547D0.13
CESCchr1050859865Missense_MutationnovelR26C0.21
CESCchr1050816084Missense_MutationnovelA355S0.31
CESCchr1050828165Missense_MutationNAE245D0.34
CESCchr1050841892Missense_MutationNAA112G0.5
CHOLchr1050841980Missense_MutationnovelY83H0.43
COADchr1050820623Nonsense_Mutationrs772118222R266*0.18
COADchr1050859890Missense_Mutationrs754321707E17D0.26
COADchr1050836227Nonsense_MutationnovelE151*0.07DND1_DSRM
COADchr1050809940Silentrs777970091G529G0.21
COADchr1050806852SilentNAP554P0.2
COADchr1050836216Silentrs76706180S154S0.3
COADchr1050813865Missense_Mutationrs190691295A447T0.08
COADchr1050813922Missense_MutationNAG428R0.11
COADchr1050850762IntronNA0.11
COADchr1050850673IntronNA0.12
COADchr1050809981Missense_Mutationrs765124661E516K0.1
COADchr1050816109SilentNAV346V0.11
COADchr1050811140Nonsense_MutationnovelQ462*0.33
COADchr1050859857SilentnovelG28G0.17
COADchr1050814027Frame_Shift_InsnovelV393Cfs*320.04
COADchr1050814028Frame_Shift_InsnovelV393Ffs*30.04
COADchr1050841989Missense_MutationnovelG80S0.3
GBMchr1050828150Missense_MutationNAE250D0.53
GBMchr1050806820Missense_MutationNAT565N0.1
GBMchr1050806771SilentnovelT581T0.44
GBMchr1050810012SilentnovelA505A0.34
GBMchr1050836304Missense_Mutationrs148254279R125H0.62
GBMchr10508066613'UTRnovel0.43
GBMchr1050828170Missense_MutationnovelE244Q0.1
GBMchr1050828202Missense_MutationnovelL233R0.09
HNSCchr1050859879Missense_Mutationrs761190953R21H0.36
HNSCchr1050806833Missense_MutationnovelK561E0.25
HNSCchr1050816253SilentnovelV298V0.3
HNSCchr1050836138SilentnovelG180G0.33
HNSCchr10508066613'UTRnovel0.25
HNSCchr1050836215Missense_MutationnovelE155K0.06DND1_DSRM
HNSCchr1050816187SilentnovelG320G0.18
HNSCchr1050811097Missense_MutationnovelR476T0.19
HNSCchr1050813951Frame_Shift_InsnovelR418Kfs*70.16
HNSCchr1050836094Missense_Mutationrs748398755A195V0.4DND1_DSRM
HNSCchr1050844097Missense_MutationnovelG42V0.16
HNSCchr1050813992Nonsense_MutationnovelY404*0.76
HNSCchr1050816217SilentnovelV310V0.28
KIRCchr1050820551Splice_SitenovelX289_splice0.26
KIRCchr1050806853Missense_MutationNAP554L0.19
KIRCchr1050841986Nonsense_MutationNAK81*0.3
LGGchr1050813889SilentnovelL439L0.14
LGGchr1050816207Nonsense_MutationNAR314*0.5
LGGchr1050806799Missense_MutationnovelA572E0.38
LGGchr1050841937Missense_MutationnovelG97E0.32
LGGchr1050816051Nonsense_MutationnovelG366*0.06
LGGchr1050836241Frame_Shift_InsnovelT146Nfs*160.31DND1_DSRM
LIHCchr1050828179Missense_MutationnovelS241P0.32
LIHCchr1050813898Missense_MutationNAP436S0.34
LIHCchr1050844027SilentNAR65R0.42
LIHCchr1050841903Missense_MutationnovelE108D0.39
LIHCchr1050816047Missense_MutationNAH367R0.29
LUADchr1050806765SilentnovelA583A0.16
LUADchr1050813888Frame_Shift_DelnovelL439*0.15
LUADchr1050836094Missense_Mutationrs748398755A195V0.06DND1_DSRM
LUADchr1050806732Missense_MutationnovelF594L0.26
LUADchr1050816058SilentNAA363A0.31
LUADchr1050841977Nonsense_MutationnovelE84*0.19
LUADchr1050816058SilentNAA363A0.27
LUADchr1050809983Missense_MutationnovelA515G0.31
LUADchr10508066843'UTRnovel0.2
LUADchr1050850799Intronnovel0.21
LUADchr1050836128Missense_MutationNAV184L0.1DND1_DSRM
LUADchr1050816037Frame_Shift_InsnovelN370Kfs*110.32
LUADchr1050859878Silentrs371584214R21R0.05
LUADchr1050841895Missense_MutationnovelN111T0.19
LUADchr1050850808Intronnovel0.36
LUADchr1050844011Nonsense_MutationnovelE71*0.42
LUADchr1050850788Intronnovel0.24
LUADchr1050841973Missense_MutationNAM85K0.36
LUADchr1050816096Frame_Shift_DelnovelQ351Rfs*340.22
LUADchr1050836091Missense_MutationnovelR196M0.09DND1_DSRM
LUSCchr1050859913Missense_Mutationrs769626580G10R0.38
LUSCchr1050820614Missense_MutationnovelA269P0.09
LUSCchr1050806822SilentnovelV564V0.09
LUSCchr1050850735Intronnovel0.29
LUSCchr1050836088Missense_MutationnovelR197M0.28DND1_DSRM
LUSCchr1050850790Intronnovel0.34
LUSCchr1050806754Missense_Mutationrs530902814R587Q0.22
LUSCchr1050811052Missense_MutationnovelQ491R0.27
LUSCchr1050806737Missense_MutationnovelT593S0.22
LUSCchr1050809969Missense_MutationnovelQ520K0.38
LUSCchr1050850760Intronnovel0.24
LUSCchr1050828140Missense_MutationNAI254F0.09
LUSCchr1050836097Missense_MutationnovelM194T0.17DND1_DSRM
LUSCchr1050828282Missense_MutationnovelL206F0.19
LUSCchr1050841933Nonsense_MutationnovelY98*0.22
LUSCchr1050816094Missense_MutationnovelQ351H0.17
LUSCchr1050850790Intronnovel0.37
LUSCchr1050836205Missense_MutationnovelK158T0.42DND1_DSRM
LUSCchr1050816177Missense_MutationnovelQ324K0.38
LUSCchr1050813898Missense_MutationNAP436S0.24
LUSCchr1050836169Missense_MutationnovelP170R0.53DND1_DSRM
LUSCchr1050816151SilentnovelG332G0.62
LUSCchr1050836117Missense_MutationnovelE187D0.22DND1_DSRM
OVchr1050810009In_Frame_InsnovelF506delinsLNHRN0.04
OVchr1050850797Intronnovel0.26
OVchr1050859864Missense_Mutationrs529819396R26H0.42
OVchr1050828236Missense_MutationNAV222L0.19
OVchr1050813983SilentNAL407L0.39
OVchr1050806805Frame_Shift_DelnovelL570Sfs*70.23
OVchr1050820562Frame_Shift_DelnovelL286*0.29
OVchr10508066813'UTRnovel0.93
PAADchr10508066933'UTRnovel0.18
PRADchr1050844036Frame_Shift_DelnovelK62Nfs*240.32
PRADchr1050836073Splice_SiteNAX202_splice0.35
PRADchr1050836094Missense_Mutationrs748398755A195V0.25DND1_DSRM
PRADchr1050813961Missense_MutationnovelG415R0.3
PRADchr1050836283Missense_MutationNAS132N0.49
PRADchr1050859878Silentrs371584214R21R0.52
PRADchr1050813897Missense_MutationnovelP436H0.15
PRADchr1050828208Missense_MutationnovelK231R0.07
PRADchr1050836164Missense_Mutationrs775569138A172T0.36DND1_DSRM
READchr1050809900In_Frame_InsnovelA540_A542dup0.31
READchr1050850679Intronnovel0.42
SARCchr1050828295Missense_MutationnovelG202E0.6
SARCchr1050813898Missense_MutationnovelP436T0.27
SKCMchr1050859881Silentrs764493898L20L0.21
SKCMchr1050816141Missense_Mutationrs574044306D336N0.22
SKCMchr1050809981Missense_Mutationrs765124661E516K0.8
SKCMchr1050841959Missense_MutationNAD90N0.22
SKCMchr1050814018SilentnovelL396L0.53
SKCMchr1050813920SilentnovelG428G0.08
SKCMchr1050828295Missense_MutationnovelG202E0.33
SKCMchr1050859858Missense_MutationNAG28E0.23
SKCMchr1050844032Missense_MutationNAP64S0.25
SKCMchr1050850784IntronNA0.49
SKCMchr1050844053Missense_MutationNAE57K0.53
SKCMchr1050816035Missense_Mutationrs781105145R371K0.24
SKCMchr1050813898Missense_MutationNAP436S0.2
SKCMchr1050816064SilentNAF361F0.4
SKCMchr1050820590Missense_MutationnovelE277K0.4
SKCMchr1050820636SilentNAR261R0.15
SKCMchr1050828210SilentNAV230V0.25
SKCMchr1050836213SilentNAE155E0.19
SKCMchr1050836302Missense_MutationNAL126F0.38
SKCMchr1050859892Missense_MutationNAE17K0.36
SKCMchr10508066253'UTRnovel0.36
SKCMchr1050820623Nonsense_Mutationrs772118222R266*0.83
SKCMchr1050828204Silentrs143315865I232I0.94
SKCMchr1050836234SilentNAK148K0.88
SKCMchr1050816064SilentNAF361F0.24
SKCMchr1050813859Nonsense_MutationnovelQ449*0.27
SKCMchr1050813860SilentnovelP448P0.27
SKCMchr10508066243'UTRnovel0.4
SKCMchr1050816018Missense_MutationNAP377S0.31
SKCMchr1050828228Missense_MutationNAE224D0.37
SKCMchr1050828277Missense_MutationnovelG208E0.36
SKCMchr1050813975Missense_MutationNAG410E0.27
SKCMchr1050806730SilentNA*595*0.25
SKCMchr1050816174Missense_MutationNAG325R0.24
SKCMchr1050844122Missense_MutationNAE34K0.32
SKCMchr1050836186Silentrs752052860V164V0.52
SKCMchr1050820630SilentNAK263K0.69
SKCMchr1050816158Missense_MutationNAS330F0.08
SKCMchr1050813866SilentNAL446L0.53
SKCMchr1050844122Missense_MutationNAE34K0.27
SKCMchr1050850670Intronnovel0.47
SKCMchr1050844122Missense_MutationNAE34K0.94
SKCMchr1050813997Missense_MutationNAA403T0.35
SKCMchr1050816148Missense_MutationNAQ333H0.47
SKCMchr1050816120Missense_MutationnovelG343R0.18
SKCMchr1050859844Nonsense_MutationNAQ33*0.23
SKCMchr1050813975Missense_MutationNAG410E0.41
SKCMchr1050859844Nonsense_MutationNAQ33*0.41
SKCMchr1050844122Missense_MutationNAE34K0.41
SKCMchr1050850716Intronnovel0.2
SKCMchr1050836144SilentnovelN178N0.27
SKCMchr1050841869Missense_MutationNAE120K0.87
SKCMchr1050836197Missense_MutationnovelE161K0.64DND1_DSRM
SKCMchr1050814009Missense_Mutationrs766706018R399C0.44
SKCMchr1050859913Missense_Mutationrs769626580G10R0.45
SKCMchr1050836249SilentNAI143I0.2
SKCMchr1050816114Missense_MutationNAP345S0.44
SKCMchr1050813921Missense_MutationNAG428E0.26
SKCMchr1050816141Missense_Mutationrs574044306D336N0.2
SKCMchr1050844122Missense_MutationNAE34K0.32
SKCMchr1050820566Missense_Mutationrs781647376A285T0.23
SKCMchr1050844057SilentNAG55G0.32
SKCMchr1050809939Missense_Mutationrs577250735D530N0.13
SKCMchr1050850785Intronnovel0.08
SKCMchr1050850807Intronnovel0.54
SKCMchr1050850807Intronnovel0.76
SKCMchr1050859885Missense_MutationNAA19V0.41
SKCMchr1050850712Intronnovel0.4
SKCMchr1050828271Missense_MutationnovelG210D0.19
SKCMchr1050813967Nonsense_MutationnovelV413*0.06
SKCMchr1050813906Missense_MutationnovelP433L0.42
SKCMchr1050828210SilentNAV230V0.47
SKCMchr1050836216Silentrs76706180S154S0.57
SKCMchr1050850724Intronrs7660037570.16
SKCMchr1050836210Missense_MutationNAM156I0.4DND1_DSRM
STADchr1050844020Missense_MutationNAF68V0.06
STADchr1050811127Missense_MutationnovelQ466R0.11
STADchr1050850799Intronnovel0.32
STADchr1050816032Missense_MutationnovelA372V0.24
STADchr1050811094Missense_MutationNAQ477R0.38
STADchr1050816273Missense_MutationnovelD292H0.18
STADchr1050850736Intronnovel0.08
STADchr10508599795'UTRnovel0.34
STADchr1050836279SilentNAV133V0.35
STADchr1050828278Nonsense_Mutationrs749028994G208*0.11
STADchr1050836257Missense_MutationNAG141W0.23DND1_DSRM
STADchr1050813866SilentNAL446L0.17
UCECchr1050811087Missense_MutationNAF479L0.32
UCECchr1050828203Missense_MutationNAL233I0.37
UCECchr1050820613Missense_MutationNAA269V0.32
UCECchr1050836180SilentNAV166V0.29
UCECchr1050806794Missense_MutationnovelT574A0.2
UCECchr1050811092Missense_MutationnovelL478I0.37
UCECchr1050828216SilentnovelS228S0.13
UCECchr1050828162Missense_MutationnovelM246I0.09
UCECchr1050836222SilentNAI152I0.28
UCECchr1050841897Missense_MutationNAK110N0.14
UCECchr1050806789SilentNAT575T0.43
UCECchr1050809947Missense_MutationnovelD527G0.37
UCECchr1050836216Silentrs76706180S154S0.39
UCECchr10508066133'UTRnovel0.37
UCECchr1050811087Missense_MutationNAF479L0.31
UCECchr10508599645'UTRnovel0.12
UCECchr10508599645'UTRnovel0.08
UCECchr1050828296Splice_SitenovelX202_splice0.15
UCECchr1050816066Missense_MutationnovelF361L0.38
UCECchr1050850803Intronnovel0.13
UCECchr1050813860SilentnovelP448P0.26
UCECchr1050816187SilentnovelG320G0.38
UCECchr1050814010SilentnovelG398G0.37
UCECchr1050850713Intronnovel0.3
UCECchr1050844006SilentnovelL72L0.07
UCECchr1050810023Missense_MutationnovelK502Q0.5
UCECchr1050811165Missense_MutationnovelE453D0.47
UCECchr1050850677Intronnovel0.14
UCECchr1050816123Missense_MutationnovelL342F0.09
UCECchr1050809994Missense_MutationnovelK511N0.19
UCECchr1050816156Missense_MutationnovelL331V0.37
UCECchr1050836227Nonsense_MutationnovelE151*0.32DND1_DSRM
UCECchr1050841990Splice_Regionrs777129780I79I0.34
UCECchr1050806810Missense_MutationnovelQ568H0.42
UCECchr1050836174SilentnovelV168V0.16
UCECchr10508599595'UTRnovel0.11
UCECchr1050809972Missense_Mutationrs546119810L519M0.12
UCECchr1050836190Missense_MutationnovelV163G0.13DND1_DSRM
UCECchr1050836305Missense_Mutationrs375285515R125C0.18
UCECchr1050836186Silentrs752052860V164V0.41
UCECchr1050806799Missense_MutationnovelA572E0.28
UCECchr1050828217Missense_MutationnovelS228Y0.45
UCECchr1050859878Silentrs371584214R21R0.47
UCECchr1050816024Nonsense_Mutationrs371633684R375*0.43
UCECchr1050816027Missense_MutationnovelI374V0.09
UCECchr1050859877Missense_MutationnovelA22T0.12
UCECchr1050813971SilentnovelY411Y0.05
UCECchr1050820650Splice_SitenovelX257_splice0.45
UCECchr1050811038Splice_SiteNAX495_splice0.4
UCECchr1050813961Nonsense_MutationnovelG415*0.43
UCECchr1050850794Intronnovel0.38
UCECchr1050806796Missense_MutationnovelY573C0.17
UCECchr1050836143Nonsense_Mutationrs760319331R179*0.31DND1_DSRM
UCECchr1050859861Missense_MutationnovelT27I0.44
UCECchr1050816160Nonsense_MutationnovelY329*0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
ESCADEL0.17390.039099
KIRPDEL0.0660.1975
SKCMDEL0.5150.059549
UCECDEL0.06860.011507

Survival Analysis
CancerP-value Q-value
HNSC0.0022

Kaplan-Meier Survival Analysis

LUSC0.0024

Kaplan-Meier Survival Analysis

BRCA0.022

Kaplan-Meier Survival Analysis

PAAD0.022

Kaplan-Meier Survival Analysis

BLCA0.0004

Kaplan-Meier Survival Analysis

UCEC0.0087

Kaplan-Meier Survival Analysis

LUAD0.0096

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000148584 (Gene tree)
Gene ID
29974
Gene Symbol
A1CF
Alias
ACF|ASP|ACF64|ACF65|APOBEC1CF
Full Name
APOBEC1 complementation factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
86,267 bases
Position
chr10:50,799,409-50,885,675
Accession
24086
RBP type
canonical RBP
Summary
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000282641DND1_DSRMPF14709.72.3e-2411
ENSP00000363109DND1_DSRMPF14709.72.3e-2411
ENSP00000363113DND1_DSRMPF14709.72.3e-2411
ENSP00000363107DND1_DSRMPF14709.72.4e-2411
ENSP00000378873DND1_DSRMPF14709.72.4e-2411
ENSP00000363105DND1_DSRMPF14709.72.4e-2411
ENSP00000378868DND1_DSRMPF14709.72.4e-2411
ENSP00000282641RRM_1PF00076.228.3e-4013
ENSP00000282641RRM_1PF00076.228.3e-4023
ENSP00000282641RRM_1PF00076.228.3e-4033
ENSP00000363109RRM_1PF00076.228.3e-4013
ENSP00000363109RRM_1PF00076.228.3e-4023
ENSP00000363109RRM_1PF00076.228.3e-4033
ENSP00000363113RRM_1PF00076.228.3e-4013
ENSP00000363113RRM_1PF00076.228.3e-4023
ENSP00000363113RRM_1PF00076.228.3e-4033
ENSP00000363105RRM_1PF00076.228.8e-4013
ENSP00000363105RRM_1PF00076.228.8e-4023
ENSP00000363105RRM_1PF00076.228.8e-4033
ENSP00000363107RRM_1PF00076.229.6e-4013
ENSP00000363107RRM_1PF00076.229.6e-4023
ENSP00000363107RRM_1PF00076.229.6e-4033
ENSP00000378873RRM_1PF00076.229.6e-4013
ENSP00000378873RRM_1PF00076.229.6e-4023
ENSP00000378873RRM_1PF00076.229.6e-4033
ENSP00000378868RRM_1PF00076.221e-3913
ENSP00000378868RRM_1PF00076.221e-3923
ENSP00000378868RRM_1PF00076.221e-3933
ENSP00000397953RRM_1PF00076.227.5e-2812
ENSP00000397953RRM_1PF00076.227.5e-2822
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10781591Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex.J Biol Chem2000 Jun 30Lellek H-
31080349Curcumin modulates the apolipoprotein B mRNA editing by coordinating the expression of cytidine deamination to uridine editosome components in primary mouse hepatocytes.Korean J Physiol Pharmacol2019 MayHe Pdoi: 10.4196/kjpp.2019.23.3.181
25585043Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing.RNA Biol2014Fossat Ndoi: 10.1080/15476286.2014.996054.
11571303Mutagenesis of apobec-1 complementation factor reveals distinct domains that modulate RNA binding, protein-protein interaction with apobec-1, and complementation of C to U RNA-editing activity.J Biol Chem2001 Dec 7Blanc V-
11577082Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor.J Biol Chem2001 Dec 14Anant S-
11134005Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing.J Biol Chem2001 Mar 30Blanc V-
20541607Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes.Biochim Biophys Acta2010 NovGalloway CAdoi: 10.1016/j.bbadis.2010.06.003
20406809Apobec-1 complementation factor modulates liver regeneration by post-transcriptional regulation of interleukin-6 mRNA stability.J Biol Chem2010 Jun 18Blanc Vdoi: 10.1074/jbc.M110.115147
24916387C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.EMBO Rep2014 AugFossat Ndoi: 10.15252/embr.201438450
27582469Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.Proc Natl Acad Sci U S A2016 Sep 13Carouge Ddoi: 10.1073/pnas.1604773113
30309881Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.RNA2019 JanBlanc Vdoi: 10.1261/rna.068395.118
31186064Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells.J Exp Clin Cancer Res2019 Jun 11Song Ydoi: 10.1186/s13046-019-1200-5.
16920700ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components.Am J Physiol Gastrointest Liver Physiol2007 JanChen Z-
14570923Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing.J Biol Chem2004 Jan 2Sowden MP-
12896982A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.J Biol Chem2003 Oct 17Blanc V-
12881431The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.EMBO J2003 Aug 1Chester A-
11870221The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors.J Cell Sci2002 Mar 1Sowden MP-
11871661Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing.RNA2002 JanMehta A-
10669759Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.Mol Cell Biol2000 MarMehta A-
16055734Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.Mol Cell Biol2005 AugBlanc V-
15103077Isolation of an mRNA-binding protein involved in C-to-U editing.Methods Mol Biol2004Gerber CA-
22923694Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.Proc Natl Acad Sci U S A2012 Oct 9Nelson VRdoi: 10.1073/pnas.1207169109
28069890APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.RNA2017 AprSnyder EMdoi: 10.1261/rna.058818.116
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000414883A1CF-208885-ENSP00000397953201 (aa)-Q5T0W7
ENST00000473480A1CF-209813--- (aa)--
ENST00000395489A1CF-2069517XM_011539729ENSP00000378868602 (aa)XP_011538031F8W9F8
ENST00000282641A1CF-2019350-ENSP00000282641586 (aa)-Q9NQ94
ENST00000493415A1CF-210926--- (aa)--
ENST00000374001A1CF-2059221XM_017016160ENSP00000363113586 (aa)XP_016871649Q9NQ94
ENST00000373997A1CF-2042116-ENSP00000363109586 (aa)-Q9NQ94
ENST00000373995A1CF-2032211-ENSP00000363107594 (aa)-Q9NQ94
ENST00000373993A1CF-2021997XM_005269718ENSP00000363105594 (aa)XP_005269775Q9NQ94
ENST00000395495A1CF-2079400-ENSP00000378873594 (aa)-Q9NQ94
Gene Model
Click here to download ENSG00000148584's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000148584Body Height6.4030000E-005-
ENSG00000148584Platelet Function Tests8.1800000E-006-
ENSG00000148584Uric Acid7E-1723263486
ENSG00000148584Thinness1E-625811787
ENSG00000148584Uric Acid1E-625811787
ENSG00000148584Narcolepsy5E-625986216
ENSG00000148584Creatinine1E-1226831199
ENSG00000148584Glomerular Filtration Rate1E-1226831199
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000148584rs109948601050885664TGlomerular filtration rate in non diabetics (creatinine)26831199[NR] unit increase0.0077EFO_0005208|EFO_0004518
ENSG00000148584rs42569221050808856CUrate levels in lean individuals25811787[0.049-0.111] kg/m2 decrease0.08EFO_0004531|EFO_0005936
ENSG00000148584rs109948561050885488AGlomerular filtration rate (creatinine)28452372[0.0051-0.0099] unit increase0.0075EFO_0005208|EFO_0004518
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000148584's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000148584A1CF9343.548ENSG00000256453DND15842.512
ENSG00000148584A1CF7433.784ENSG00000101489CELF45830.508
ENSG00000148584A1CF9873.469ENSG00000163694RBM479273.000
ENSG00000148584A1CF9259.358ENSG00000135316SYNCRIP8545.161
ENSG00000148584A1CF9258.289ENSG00000125944HNRNPR5951.724
ENSG00000148584A1CF9573.158ENSG00000151962RBM469860.305
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000148584A1CF10088.119ENSAPOG00000008259a1cf10074.242Acanthochromis_polyacanthus
ENSG00000148584A1CF10097.015ENSAMEG00000000523A1CF10095.623Ailuropoda_melanoleuca
ENSG00000148584A1CF10088.119ENSACIG00000008632a1cf10077.355Amphilophus_citrinellus
ENSG00000148584A1CF10088.119ENSAOCG00000023744a1cf9684.348Amphiprion_ocellaris
ENSG00000148584A1CF10087.624ENSAPEG00000009537a1cf10075.738Amphiprion_percula
ENSG00000148584A1CF10088.614ENSATEG00000013720a1cf10078.218Anabas_testudineus
ENSG00000148584A1CF10095.522ENSAPLG00000002964A1CF10088.908Anas_platyrhynchos
ENSG00000148584A1CF10091.045ENSACAG00000015269A1CF10083.646Anolis_carolinensis
ENSG00000148584A1CF10099.502ENSANAG00000019974A1CF10098.637Aotus_nancymaae
ENSG00000148584A1CF10089.109ENSACLG00000017428a1cf10076.119Astatotilapia_calliptera
ENSG00000148584A1CF10074.876ENSAMXG00000018180a1cf10075.041Astyanax_mexicanus
ENSG00000148584A1CF10099.005ENSBTAG00000021195A1CF10096.468Bos_taurus
ENSG00000148584A1CF10099.502ENSCJAG00000005045A1CF10098.655Callithrix_jacchus
ENSG00000148584A1CF10097.015ENSCAFG00000015581A1CF10095.455Canis_familiaris
ENSG00000148584A1CF10097.015ENSCAFG00020026421A1CF10095.455Canis_lupus_dingo
ENSG00000148584A1CF10099.005ENSCHIG00000020411A1CF10095.462Capra_hircus
ENSG00000148584A1CF10092.359ENSTSYG00000001755A1CF10096.926Carlito_syrichta
ENSG00000148584A1CF10082.822ENSCAPG00000017386A1CF8995.868Cavia_aperea
ENSG00000148584A1CF10099.005ENSCPOG00000009807A1CF10095.960Cavia_porcellus
ENSG00000148584A1CF10099.502ENSCCAG00000018168A1CF10098.151Cebus_capucinus
ENSG00000148584A1CF10099.005ENSCATG00000043715A1CF10097.785Cercocebus_atys
ENSG00000148584A1CF10099.005ENSCLAG00000010424A1CF10095.973Chinchilla_lanigera
ENSG00000148584A1CF10099.502ENSCSAG00000007032A1CF10098.151Chlorocebus_sabaeus
ENSG00000148584A1CF9991.414ENSCHOG00000009089A1CF9991.582Choloepus_hoffmanni
ENSG00000148584A1CF10094.527ENSCPBG00000026464A1CF10088.403Chrysemys_picta_bellii
ENSG00000148584A1CF10099.502ENSCANG00000038032A1CF10098.151Colobus_angolensis_palliatus
ENSG00000148584A1CF10098.507ENSCGRG00001017413A1cf10094.286Cricetulus_griseus_chok1gshd
ENSG00000148584A1CF10098.507ENSCGRG00000017332A1cf10093.613Cricetulus_griseus_crigri
ENSG00000148584A1CF10083.168ENSCSEG00000002361a1cf10076.119Cynoglossus_semilaevis
ENSG00000148584A1CF10087.624ENSCVAG00000010520a1cf10077.228Cyprinodon_variegatus
ENSG00000148584A1CF10087.562ENSDARG00000002968a1cf10080.405Danio_rerio
ENSG00000148584A1CF10097.015ENSDNOG00000002829A1CF10095.126Dasypus_novemcinctus
ENSG00000148584A1CF6199.180ENSDORG00000025837-10099.180Dipodomys_ordii
ENSG00000148584A1CF9490.426ENSETEG00000012527A1CF8491.349Echinops_telfairi
ENSG00000148584A1CF10099.502ENSEASG00005012924A1CF10096.482Equus_asinus_asinus
ENSG00000148584A1CF10099.005ENSECAG00000010424A1CF10095.980Equus_caballus
ENSG00000148584A1CF6199.187ENSEEUG00000000013A1CF10081.441Erinaceus_europaeus
ENSG00000148584A1CF10087.562ENSELUG00000003159a1cf10079.833Esox_lucius
ENSG00000148584A1CF10096.020ENSFCAG00000011179A1CF10094.369Felis_catus
ENSG00000148584A1CF10095.025ENSFALG00000013183A1CF10086.882Ficedula_albicollis
ENSG00000148584A1CF10099.502ENSFDAG00000019371A1CF10095.571Fukomys_damarensis
ENSG00000148584A1CF10072.277ENSFHEG00000019652a1cf9682.031Fundulus_heteroclitus
ENSG00000148584A1CF10080.597ENSGMOG00000018943a1cf10072.066Gadus_morhua
ENSG00000148584A1CF9983.973ENSGALG00000003765A1CF9787.766Gallus_gallus
ENSG00000148584A1CF10087.129ENSGAFG00000014868a1cf10071.667Gambusia_affinis
ENSG00000148584A1CF10081.188ENSGACG00000010241a1cf10075.000Gasterosteus_aculeatus
ENSG00000148584A1CF9488.434ENSGAGG00000016508A1CF9887.831Gopherus_agassizii
ENSG00000148584A1CF100100.000ENSGGOG00000009670A1CF10099.832Gorilla_gorilla
ENSG00000148584A1CF10089.109ENSHBUG00000021959a1cf10077.190Haplochromis_burtoni
ENSG00000148584A1CF10098.507ENSHGLG00000008955A1CF10096.134Heterocephalus_glaber_female
ENSG00000148584A1CF10098.507ENSHGLG00100000518A1CF10095.462Heterocephalus_glaber_male
ENSG00000148584A1CF10083.168ENSHCOG00000017669a1cf10072.638Hippocampus_comes
ENSG00000148584A1CF10087.562ENSIPUG00000010367a1cf9683.209Ictalurus_punctatus
ENSG00000148584A1CF6199.180ENSSTOG00000005763-10099.180Ictidomys_tridecemlineatus
ENSG00000148584A1CF6199.180ENSJJAG00000011550-10099.180Jaculus_jaculus
ENSG00000148584A1CF10088.614ENSKMAG00000006568a1cf10077.398Kryptolebias_marmoratus
ENSG00000148584A1CF10088.614ENSLBEG00000020994a1cf9876.847Labrus_bergylta
ENSG00000148584A1CF10091.045ENSLACG00000008061A1CF10082.203Latimeria_chalumnae
ENSG00000148584A1CF10090.050ENSLOCG00000006302a1cf10082.137Lepisosteus_oculatus
ENSG00000148584A1CF10097.512ENSLAFG00000015462A1CF10094.454Loxodonta_africana
ENSG00000148584A1CF10099.502ENSMFAG00000035948A1CF10098.126Macaca_fascicularis
ENSG00000148584A1CF10099.502ENSMMUG00000007077A1CF10098.126Macaca_mulatta
ENSG00000148584A1CF10099.502ENSMNEG00000031454A1CF10097.785Macaca_nemestrina
ENSG00000148584A1CF10099.005ENSMLEG00000037223A1CF10097.815Mandrillus_leucophaeus
ENSG00000148584A1CF10088.119ENSMAMG00000010402a1cf10076.987Mastacembelus_armatus
ENSG00000148584A1CF10089.109ENSMZEG00005013245a1cf10076.795Maylandia_zebra
ENSG00000148584A1CF10094.059ENSMGAG00000001507A1CF10087.919Meleagris_gallopavo
ENSG00000148584A1CF10098.010ENSMAUG00000007422A1cf10093.782Mesocricetus_auratus
ENSG00000148584A1CF10099.005ENSMICG00000003377A1CF10096.102Microcebus_murinus
ENSG00000148584A1CF10098.507ENSMOCG00000021536A1cf10093.782Microtus_ochrogaster
ENSG00000148584A1CF10075.248ENSMMOG00000009422a1cf10070.266Mola_mola
ENSG00000148584A1CF10097.015ENSMODG00000016478A1CF9991.450Monodelphis_domestica
ENSG00000148584A1CF10087.129ENSMALG00000012992a1cf10072.927Monopterus_albus
ENSG00000148584A1CF10097.015MGP_CAROLIEiJ_G0022873A1cf10093.613Mus_caroli
ENSG00000148584A1CF10097.015ENSMUSG00000052595A1cf9995.801Mus_musculus
ENSG00000148584A1CF10096.517MGP_PahariEiJ_G0014366A1cf10092.773Mus_pahari
ENSG00000148584A1CF10097.015MGP_SPRETEiJ_G0023792A1cf10093.109Mus_spretus
ENSG00000148584A1CF10090.236ENSMPUG00000016971A1CF10090.236Mustela_putorius_furo
ENSG00000148584A1CF10098.507ENSMLUG00000016071A1CF10094.454Myotis_lucifugus
ENSG00000148584A1CF10097.512ENSNGAG00000015136A1cf10094.958Nannospalax_galili
ENSG00000148584A1CF10089.109ENSNBRG00000001712a1cf10077.521Neolamprologus_brichardi
ENSG00000148584A1CF10099.502ENSNLEG00000012028A1CF10098.992Nomascus_leucogenys
ENSG00000148584A1CF9491.155ENSMEUG00000015909A1CF10091.155Notamacropus_eugenii
ENSG00000148584A1CF10096.517ENSOPRG00000010667A1CF9785.849Ochotona_princeps
ENSG00000148584A1CF6195.082ENSODEG00000012177-10095.082Octodon_degus
ENSG00000148584A1CF10089.109ENSONIG00000019105a1cf10077.025Oreochromis_niloticus
ENSG00000148584A1CF10095.522ENSOANG00000007360A1CF9990.196Ornithorhynchus_anatinus
ENSG00000148584A1CF10098.010ENSOCUG00000011587A1CF10094.898Oryctolagus_cuniculus
ENSG00000148584A1CF10087.624ENSORLG00000013342a1cf10073.744Oryzias_latipes
ENSG00000148584A1CF10087.624ENSORLG00020000586a1cf10075.733Oryzias_latipes_hni
ENSG00000148584A1CF10087.624ENSORLG00015018569a1cf10075.570Oryzias_latipes_hsok
ENSG00000148584A1CF10087.624ENSOMEG00000013531a1cf10075.124Oryzias_melastigma
ENSG00000148584A1CF10098.507ENSOGAG00000012884A1CF10095.623Otolemur_garnettii
ENSG00000148584A1CF10099.005ENSOARG00000013695A1CF10095.462Ovis_aries
ENSG00000148584A1CF100100.000ENSPPAG00000028115A1CF100100.000Pan_paniscus
ENSG00000148584A1CF10096.517ENSPPRG00000012180A1CF10094.781Panthera_pardus
ENSG00000148584A1CF10096.517ENSPTIG00000021223A1CF10094.781Panthera_tigris_altaica
ENSG00000148584A1CF100100.000ENSPTRG00000002508A1CF10099.663Pan_troglodytes
ENSG00000148584A1CF10099.502ENSPANG00000021988A1CF10098.126Papio_anubis
ENSG00000148584A1CF10087.065ENSPKIG00000025176a1cf10080.333Paramormyrops_kingsleyae
ENSG00000148584A1CF10093.532ENSPSIG00000010318A1CF10087.905Pelodiscus_sinensis
ENSG00000148584A1CF10084.080ENSPMGG00000013359a1cf9968.503Periophthalmus_magnuspinnatus
ENSG00000148584A1CF10099.005ENSPEMG00000015021A1cf10094.454Peromyscus_maniculatus_bairdii
ENSG00000148584A1CF10094.030ENSPCIG00000002175A1CF10090.971Phascolarctos_cinereus
ENSG00000148584A1CF10087.129ENSPFOG00000006683a1cf10077.362Poecilia_formosa
ENSG00000148584A1CF10087.129ENSPFOG00000007437-10077.199Poecilia_formosa
ENSG00000148584A1CF10087.129ENSPLAG00000001210-10077.063Poecilia_latipinna
ENSG00000148584A1CF10087.129ENSPLAG00000000026a1cf10077.063Poecilia_latipinna
ENSG00000148584A1CF10087.129ENSPMEG00000000921a1cf10069.536Poecilia_mexicana
ENSG00000148584A1CF10087.129ENSPMEG00000015529-10069.771Poecilia_mexicana
ENSG00000148584A1CF10086.139ENSPREG00000016298a1cf10077.036Poecilia_reticulata
ENSG00000148584A1CF10099.005ENSPPYG00000002819A1CF10098.807Pongo_abelii
ENSG00000148584A1CF7974.784ENSPCAG00000006463A1CF7974.784Procavia_capensis
ENSG00000148584A1CF10099.005ENSPCOG00000024172A1CF10096.812Propithecus_coquereli
ENSG00000148584A1CF10089.109ENSPNYG00000017944a1cf10077.488Pundamilia_nyererei
ENSG00000148584A1CF10087.562ENSPNAG00000007704a1cf10081.040Pygocentrus_nattereri
ENSG00000148584A1CF10098.010ENSRNOG00000033195A1cf10093.526Rattus_norvegicus
ENSG00000148584A1CF10091.457ENSRBIG00000042892A1CF10096.620Rhinopithecus_bieti
ENSG00000148584A1CF10099.502ENSRROG00000041398A1CF10098.151Rhinopithecus_roxellana
ENSG00000148584A1CF10099.502ENSSBOG00000021930A1CF10098.487Saimiri_boliviensis_boliviensis
ENSG00000148584A1CF10097.015ENSSHAG00000005096A1CF10090.084Sarcophilus_harrisii
ENSG00000148584A1CF10088.557ENSSFOG00015011774a1cf10080.336Scleropages_formosus
ENSG00000148584A1CF10086.634ENSSMAG00000013271a1cf10075.407Scophthalmus_maximus
ENSG00000148584A1CF10087.129ENSSDUG00000013930a1cf10077.612Seriola_dumerili
ENSG00000148584A1CF10087.129ENSSLDG00000004290a1cf10071.405Seriola_lalandi_dorsalis
ENSG00000148584A1CF8698.256ENSSARG00000005940A1CF9982.624Sorex_araneus
ENSG00000148584A1CF9984.193ENSSPUG00000006797A1CF9984.193Sphenodon_punctatus
ENSG00000148584A1CF6580.153ENSSPAG00000017066-8980.153Stegastes_partitus
ENSG00000148584A1CF10099.502ENSSSCG00000010431A1CF10096.134Sus_scrofa
ENSG00000148584A1CF10095.025ENSTGUG00000005090A1CF10086.957Taeniopygia_guttata
ENSG00000148584A1CF10084.653ENSTRUG00000001982a1cf10074.878Takifugu_rubripes
ENSG00000148584A1CF10085.644ENSTNIG00000003580a1cf10075.285Tetraodon_nigroviridis
ENSG00000148584A1CF10088.067ENSTTRG00000013190A1CF10088.235Tursiops_truncatus
ENSG00000148584A1CF10097.015ENSUAMG00000020065A1CF10095.563Ursus_americanus
ENSG00000148584A1CF10096.517ENSUMAG00000011162A1CF10095.118Ursus_maritimus
ENSG00000148584A1CF9981.926ENSVPAG00000006130A1CF9981.926Vicugna_pacos
ENSG00000148584A1CF10097.015ENSVVUG00000002504A1CF10095.222Vulpes_vulpes
ENSG00000148584A1CF10088.557ENSXETG00000006611a1cf10078.297Xenopus_tropicalis
ENSG00000148584A1CF10086.634ENSXCOG00000003302a1cf10077.907Xiphophorus_couchianus
ENSG00000148584A1CF10086.634ENSXMAG00000016703a1cf10078.033Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding21873635.IBAFunction
GO:0003725double-stranded RNA binding11871661.IDAFunction
GO:0003727single-stranded RNA binding11871661.IDAFunction
GO:0003729mRNA binding21873635.IBAFunction
GO:0005515protein binding10669759.12896982.25416956.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm12881431.IDAComponent
GO:0005783endoplasmic reticulum-IEAComponent
GO:0006397mRNA processing-IEAProcess
GO:0010609mRNA localization resulting in posttranscriptional regulation of gene expression21873635.IBAProcess
GO:0016554cytidine to uridine editing21873635.IBAProcess
GO:0016554cytidine to uridine editing-TASProcess
GO:0016556mRNA modification21873635.IBAProcess
GO:0030895apolipoprotein B mRNA editing enzyme complex21873635.IBAComponent
GO:0030895apolipoprotein B mRNA editing enzyme complex10781591.IDAComponent
GO:0050821protein stabilization12881431.IDAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us