EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30060823Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.Tissue Cell2018 AugWang Xdoi: 10.1016/j.tice.2018.05.006
30022709The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.Biosci Biotechnol Biochem2018 OctYu Gdoi: 10.1080/09168451.2018.1484271
24148822A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.Carcinogenesis2014 MarMahmood SFdoi: 10.1093/carcin/bgt351
20862326Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H.PLoS Genet2010 Sep 16Pittman AMdoi: 10.1371/journal.pgen.1001126.
16652384Overexpression of EIF3S3 promotes cancer cell growth.Prostate2006 Aug 1Savinainen KJ-
14997205Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer.Br J Cancer2004 Mar 8Savinainen KJ-
11733359Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer.Am J Pathol2001 DecSaramki O-
30232453mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.Nature2018 SepChoe Jdoi: 10.1038/s41586-018-0538-8

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr8116648875Missense_MutationnovelM253I0.3
BRCAchr81167558075'UTRnovel0.09
BRCAchr81166448763'UTRnovel0.92
BRCAchr8116755669SilentnovelG43G0.08
BRCAchr81166449453'UTRnovel0.18
CESCchr8116658727Intronnovel0.4
CESCchr8116646485Missense_Mutationrs765673805S316L0.39
CESCchr8116755697Missense_MutationNAS34L0.37
CHOLchr8116755754Missense_MutationnovelS15Y0.38
CHOLchr8116755755Missense_MutationnovelS15T0.35
COADchr8116658768Intronnovel0.25
COADchr8116648868Missense_MutationnovelD256N0.08
COADchr8116755791Missense_MutationnovelS3P0.28
COADchr8116658783Intronnovel0.11
COADchr8116657225Frame_Shift_DelnovelS183Pfs*50.05
COADchr8116646586SilentNAQ282Q0.15
COADchr8116646547Silentrs770749973P295P0.21
COADchr8116755713Missense_MutationnovelG29C0.11
ESCAchr8116646547Silentrs770749973P295P0.33
GBMchr8116658956Missense_MutationNAR105Q0.05
GBMchr8116755771SilentnovelG9G0.13
GBMchr8116726088Missense_MutationNAE73K0.4
GBMchr8116646497Missense_MutationnovelA312V0.1
HNSCchr8116655882SilentnovelK227K0.24
HNSCchr8116656002Missense_MutationNAL187F0.21
HNSCchr8116646520SilentnovelL304L0.13
HNSCchr8116658820SilentnovelL150L0.17
HNSCchr8116646547SilentnovelP295P0.23
KIRPchr8116648912Missense_MutationNAK241T0.25
LIHCchr8116658701Intronnovel0.14
LIHCchr8116646595SilentNAQ279Q0.4
LIHCchr8116655890Missense_Mutationrs755682334A225S0.36
LIHCchr8116658964Missense_MutationnovelE102D0.14
LUADchr8116646502SilentNAP310P0.22
LUADchr8116658914Missense_MutationnovelW119S0.5
LUADchr8116658852Missense_MutationNAY140N0.08
LUADchr8116755782Nonsense_MutationnovelE6*0.36
LUADchr8116755783SilentnovelK5K0.36
LUSCchr8116726163Missense_MutationnovelK48E0.13
LUSCchr8116657280SilentNAL164L0.36
LUSCchr8116658878Missense_MutationNAR131L0.41
LUSCchr8116657239Missense_MutationnovelK178R0.38
LUSCchr8116655914Frame_Shift_DelnovelE217Nfs*300.21
LUSCchr8116655915Missense_Mutationrs754971614W216C0.21
OVchr8116658757Intronnovel0.14
PAADchr8116655968Missense_MutationnovelE199K0.09
READchr8116658930Missense_Mutationrs367787019H114Y0.2
READchr8116657237Nonsense_MutationNAE179*0.04
READchr8116658956Missense_MutationNAR105Q0.05
READchr8116648824SilentNAQ270Q0.1
SKCMchr81167558215'UTRrs1996234190.3
SKCMchr8116646565In_Frame_DelnovelQ283_Q289del0.24
SKCMchr81167558175'UTRrs743441820.48
SKCMchr81166449413'UTRnovel0.37
SKCMchr81167558175'UTRrs743441820.29
SKCMchr8116755790Missense_MutationNAS3F0.23
SKCMchr8116646604Splice_SiteNAX277_splice0.27
SKCMchr8116645066Silentrs771805150F333F0.43
SKCMchr8116646600Nonsense_MutationnovelQ278*0.38
STADchr8116646577SilentNAN285N0.23
STADchr8116646509Missense_Mutationrs200534489P308L0.35
STADchr8116658647Intronnovel0.3
STADchr8116646505SilentnovelQ309Q0.08
STADchr8116646533Missense_MutationNAD300V0.08
STADchr8116658957Missense_MutationNAR105W0.21
STADchr81166449663'UTRnovel0.37
STADchr8116658862SilentNAS136S0.13
STADchr8116658785Intronnovel0.14
STADchr8116657225Frame_Shift_DelnovelS183Pfs*50.21
UCECchr8116648907Missense_MutationnovelL243I0.03
UCECchr8116655853Splice_Regionnovel0.21
UCECchr8116655930SilentnovelI211I0.09
UCECchr8116726058Missense_MutationnovelP83T0.05
UCECchr8116655904Missense_MutationnovelK220T0.4
UCECchr8116658754Intronnovel0.29
UCECchr8116755723SilentnovelG25G0.36
UCECchr8116726038Missense_MutationNAE89D0.22
UCECchr81166449023'UTRnovel0.21
UCECchr81166449603'UTRrs7503797900.23
UCECchr8116655872Missense_MutationNAL231I0.26
UCECchr8116648820Nonsense_MutationnovelQ272*0.17
UCECchr8116755791Missense_MutationnovelS3P0.3
UCECchr8116726142Nonsense_MutationnovelE55*0.65
UCECchr81167560205'Flanknovel0.56
UCECchr8116658882Missense_MutationnovelT130A0.48
UCECchr8116755721Missense_MutationnovelK26R0.33
UCECchr8116755680Nonsense_MutationnovelQ40*0.1
UCECchr81166448863'UTRnovel0.45
UCECchr8116658817Missense_MutationNAI151M0.27
UCECchr81166448873'UTRnovel0.29
UCECchr8116658805Splice_Regionnovel0.69
UCECchr8116726030Missense_MutationnovelA92D0.54
UCECchr8116646502Silentrs201413928P310P0.34
UCECchr81166449023'UTRnovel0.24
UCECchr8116658886Missense_MutationnovelF128L0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.20830.018626
KIRCAMP0.11360.15559
LGGAMP0.16576.7949e-16
LIHCAMP0.61081.1795e-21
SARCAMP0.27240.18425
SKCMAMP0.44142.8957e-05
TGCTAMP0.58670.13696
THCADEL0.010.038162
UVMAMP0.73758.8879e-13

Survival Analysis
CancerP-value Q-value
THYM0.00057

Kaplan-Meier Survival Analysis

KIRC0.017

Kaplan-Meier Survival Analysis

SARC0.014

Kaplan-Meier Survival Analysis

ACC0.017

Kaplan-Meier Survival Analysis

HNSC0.018

Kaplan-Meier Survival Analysis

SKCM0.0014

Kaplan-Meier Survival Analysis

BRCA0.017

Kaplan-Meier Survival Analysis

ESCA0.032

Kaplan-Meier Survival Analysis

KIRP0.0008

Kaplan-Meier Survival Analysis

PAAD0.0023

Kaplan-Meier Survival Analysis

CESC0.0027

Kaplan-Meier Survival Analysis

LAML0.028

Kaplan-Meier Survival Analysis

LIHC0.00036

Kaplan-Meier Survival Analysis

LUAD0.0058

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000147677 (Gene tree)
Gene ID
8667
Gene Symbol
EIF3H
Alias
eIF3-gamma|eIF3-p40|eIF3h|EIF3S3
Full Name
eukaryotic translation initiation factor 3 subunit H
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
124,796 bases
Position
chr8:116,642,130-116,766,925
Accession
3273
RBP type
non-canonical RBP
Summary
(Eukaryotic Translation Initiation Factor 3 Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include Trichorhinophalangeal Syndrome, Type I and Trichorhinophalangeal Syndrome, Type Ii. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is COPS5.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9341143Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.J Biol Chem1997 Oct 24Asano K-
20816988Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit.J Mol Biol2010 Oct 22Cai Qdoi: 10.1016/j.jmb.2010.07.054
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000517974EIF3H-202594--- (aa)--
ENST00000522453EIF3H-210518-ENSP00000428885170 (aa)-E5RFH0
ENST00000611080EIF3H-2121265-ENSP00000482724349 (aa)-A0A087WZK9
ENST00000518034EIF3H-2031047--- (aa)--
ENST00000520289EIF3H-207855--- (aa)--
ENST00000276682EIF3H-2012041-ENSP00000276682366 (aa)-B3KS98
ENST00000518949EIF3H-204843-ENSP00000428195244 (aa)-E5RJT0
ENST00000520813EIF3H-208562-ENSP0000042790897 (aa)-E5RFW7
ENST00000519046EIF3H-206488-ENSP0000043092646 (aa)-E5RHC7
ENST00000521861EIF3H-2093959-ENSP00000429931352 (aa)-O15372
ENST00000522800EIF3H-211635-ENSP0000042988456 (aa)-E5RH59
ENST00000518995EIF3H-205731-ENSP00000428669235 (aa)-E5RGU4
Gene Model
Click here to download ENSG00000147677's gene model file
Pathways
Pathway IDPathway NameSource
hsa03013RNA transportKEGG
hsa05162MeaslesKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000147677Cholesterol, HDL1.2431066840602E-717903299
ENSG00000147677Triglycerides9.54e-005-
ENSG00000147677Triglycerides9.54e-005-
ENSG00000147677Body Mass Index6E-625673413
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000147677rs178114508116729674?Heel bone mineral density30595370EFO_0009270
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147677's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000147677EIF3H8939.941WBGene00001231eif-3.H9239.349Caenorhabditis_elegans
ENSG00000147677EIF3H9445.152FBgn0022023eIF3h9346.372Drosophila_melanogaster
ENSG00000147677EIF3H10097.159ENSMUSG00000022312Eif3h10097.159Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001732formation of cytoplasmic translation initiation complex-IEAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0003743translation initiation factor activity21873635.IBAFunction
GO:0003743translation initiation factor activity17322308.18599441.ICFunction
GO:0003743translation initiation factor activity17581632.25849773.IDAFunction
GO:0005515protein binding12812986.16189514.17043677.18599441.18628297.19060904.19615732.19748344.22190034.23623729.26100019.IPIFunction
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0005852eukaryotic translation initiation factor 3 complex21873635.IBAComponent
GO:0005852eukaryotic translation initiation factor 3 complex17322308.17581632.18599441.25849773.IDAComponent
GO:0006413translational initiation17322308.18599441.ICProcess
GO:0006413translational initiation17581632.IDAProcess
GO:0006413translational initiation-TASProcess
GO:0006446regulation of translational initiation9341143.TASProcess
GO:0006508proteolysis-IEAProcess
GO:0008237metallopeptidase activity21873635.IBAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016282eukaryotic 43S preinitiation complex21873635.IBAComponent
GO:0033290eukaryotic 48S preinitiation complex-IEAComponent
GO:0042788polysomal ribosome21873635.IBAComponent
GO:0070062extracellular exosome19056867.HDAComponent
GO:0071541eukaryotic translation initiation factor 3 complex, eIF3m-IEAComponent
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