EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23408429	The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer.	J Biol Chem	2013 Mar 29	Zhang N	doi: 10.1074/jbc.M112.395913
24829140	AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer.	Med Oncol	2014 Jun	Yang G	doi: 10.1007/s12032-014-0986-4
27793010	Elevated AEG-1 expression in macrophages promotes hypopharyngeal cancer invasion through the STAT3-MMP-9 signaling pathway.	Oncotarget	2016 Nov 22	Liu X	doi: 10.18632/oncotarget.12886.
21495225	Expression of astrocyte elevated gene-1: a novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer.	Int J Gynecol Cancer	2010 Oct	Song H	-
21259255	Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer.	J Surg Oncol	2011 Feb	Li C	doi: 10.1002/jso.21788
26710214	Astrocyte Elevated Gene-1 as a Novel Clinicopathological and Prognostic Biomarker for Gastrointestinal Cancers: A Meta-Analysis with 2999 Patients.	PLoS One	2015 Dec 28	Luo Y	doi: 10.1371/journal.pone.0145659
25432696	MicroRNA-542-3p suppresses cell growth of gastric cancer cells via targeting oncogene astrocyte-elevated gene-1.	Med Oncol	2015 Jan	Shen X	doi: 10.1007/s12032-014-0361-5
29048632	MicroRNA-1297 inhibits metastasis and epithelial-mesenchymal transition by targeting AEG-1 in cervical cancer.	Oncol Rep	2017 Nov	Wang Z	doi: 10.3892/or.2017.5979
28941723	AEG-1 mRNA expression in non-small cell lung cancer is associated with increased tumor angiogenesis.	Pathol Res Pract	2017 Oct	Ma Z	doi: 10.1016/j.prp.2017.09.003
29207012	MicroRNA30a5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway.	Int J Mol Med	2018 Feb	Li J	doi: 10.3892/ijmm.2017.3269
29478367	MicroRNA-30a Mediates Cell Migration and Invasion by Targeting Metadherin in Colorectal Cancer.	Technol Cancer Res Treat	2018 Jan 1	Jin H	doi: 10.1177/1533033818758108.
20625905	Prognostic significance of AEG-1 expression in colorectal carcinoma.	Int J Colorectal Dis	2010 Oct	Song H	doi: 10.1007/s00384-010-1009-3
25193383	Genetic deletion of AEG-1 prevents hepatocarcinogenesis.	Cancer Res	2014 Nov 1	Robertson CL	doi: 10.1158/0008-5472.CAN-14-1357
25182604	Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival.	J Neurooncol	2015 Jan	Park KJ	doi: 10.1007/s11060-014-1603-2
24119914	Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis.	J Pediatr Urol	2014 Apr	Guo F	doi: 10.1016/j.jpurol.2013.09.010
22967897	MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2.	FEBS Lett	2012 Oct 19	Yang Y	doi: 10.1016/j.febslet.2012.08.003
22195048	Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells.	PLoS One	2011	Zhao Y	doi: 10.1371/journal.pone.0029363
20388776	Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion.	Cancer Res	2010 May 1	Liu L	doi: 10.1158/0008-5472.CAN-09-3838
27667169	AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells.	Oncol Rep	2016 Nov	Park SY	doi: 10.3892/or.2016.5106
20845990	Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression.	Neoplasma	2010	Chen W	-
24656097	Expression of AEG-1 and microvessel density correlates with metastasis and prognosis of oral squamous cell carcinoma.	Hum Pathol	2014 Apr	Xia X	doi: 10.1016/j.humpath.2013.08.030
26589417	Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway.	Tumour Biol	2016 May	Li WF	doi: 10.1007/s13277-015-4456-1
23851509	MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin.	Oncogene	2014 Jun 12	Zhang N	doi: 10.1038/onc.2013.286
27339400	Tetraspanin 8 mediates AEG-1-induced invasion and metastasis in hepatocellular carcinoma cells.	FEBS Lett	2016 Aug	Akiel MA	doi: 10.1002/1873-3468.12268
26096243	Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms.	Niger J Clin Pract	2015 Sep-Oct	Erdem H	doi: 10.4103/1119-3077.158961.
29315995	MicroRNA-1271 suppresses the proliferation and invasion of colorectal cancer cells by regulating metadherin/Wnt signaling.	J Biochem Mol Toxicol	2018 Feb	Sun X	doi: 10.1002/jbt.22028
29152659	MicroRNA216b inhibits cell proliferation and invasion in glioma by directly targeting metadherin.	Mol Med Rep	2017 Dec	Chen Z	doi: 10.3892/mmr.2017.7829
29286115	MicroRNA-379 inhibits cell proliferation and invasion in glioma via targeting metadherin and regulating PTEN/AKT pathway.	Mol Med Rep	2018 Mar	Li L	doi: 10.3892/mmr.2017.8361
23240043	The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility.	PLoS One	2012	Yuan C	doi: 10.1371/journal.pone.0051561
23595222	Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-??B pathway.	Tumour Biol	2013 Aug	Zhang J	doi: 10.1007/s13277-013-0794-z
22367022	Metadherin regulates radioresistance in cervical cancer cells.	Oncol Rep	2012 May	Zhao Y	doi: 10.3892/or.2012.1692
26156805	The key role of astrocyte elevated gene-1 in CCR6-induced EMT in cervical cancer.	Tumour Biol	2015 Dec	Zhang J	doi: 10.1007/s13277-015-3760-0
22898150	Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival.	Asia Pac J Clin Oncol	2012 Sep	Zhou J	doi: 10.1111/j.1743-7563.2012.01541.x
26122237	PROTEIN EXPRESSION OF METADHERIN AND SENSIBILITY OF BREAST CANCER MDA-MB-231 CELLS TO TREATMENT BEFORE AND AFTER TRANSFECTION.	J Biol Regul Homeost Agents	2015 Apr-Jun	Zhao H	-
25483832	Overexpression of astrocyte-elevated gene-1 is associated with ovarian cancer development and progression.	Mol Med Rep	2015 Apr	Zhou B	doi: 10.3892/mmr.2014.3056
28323000	Knockdown of astrocyte elevated gene-1 inhibited cell growth and induced apoptosis and suppressed invasion in ovarian cancer cells.	Gene	2017 Jun 15	Wang J	doi: 10.1016/j.gene.2017.03.024
27746178	MicroRNA-1297 inhibits prostate cancer cell proliferation and invasion by targeting the AEG-1/Wnt signaling pathway.	Biochem Biophys Res Commun	2016 Nov 11	Liang X	doi: 10.1016/j.bbrc.2016.10.029
28401704	HIF-1α binding to AEG-1 promoter induced upregulated AEG-1 expression associated with metastasis in ovarian cancer.	Cancer Med	2017 May	Zhao T	doi: 10.1002/cam4.1053
28731152	AEG-1 associates with metastasis in papillary thyroid cancer through upregulation of MMP2/9.	Int J Oncol	2017 Sep	Huang LL	doi: 10.3892/ijo.2017.4074
29115517	MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin.	Mol Med Rep	2018 Jan	Liao Z	doi: 10.3892/mmr.2017.7908
23889989	Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer.	Adv Cancer Res	2013	Wan L	doi: 10.1016/B978-0-12-401676-7.00004-8.
22246354	[Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue].	Zhong Nan Da Xue Xue Bao Yi Xue Ban	2011 Dec	Deng N	doi: 10.3969/j.issn.1672-7347.2011.12.012.
25652471	Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway.	Tumour Biol	2015 Jul	Zou Y	doi: 10.1007/s13277-015-3174-z
25431427	RNA interference-mediated knockdown of astrocyte elevated gene-1 inhibits growth, induces apoptosis, and increases the chemosensitivity to 5-fluorouracil in renal cancer Caki-1 cells.	Mol Cells	2014 Dec 31	Wang P	doi: 10.14348/molcells.2014.0081
24675891	Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance.	Cell Cycle	2014	Liu X	doi: 10.4161/cc.28607
22643064	Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines.	J Transl Med	2012 May 29	Gnosa S	doi: 10.1186/1479-5876-10-109.
22351252	Clinical implications of AEG-1 in liver metastasis of colorectal cancer.	Med Oncol	2012 Dec	Jiang T	doi: 10.1007/s12032-012-0186-z
22340175	Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression.	Chin Med J (Engl)	2011 Nov	Zhang X	-
21371176	Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition.	Cancer Sci	2011 Jun	Li X	doi: 10.1111/j.1349-7006.2011.01919.x
19383828	LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals.	Clin Cancer Res	2009 May 1	Thirkettle HJ	doi: 10.1158/1078-0432.CCR-08-2046
22903204	Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.	Breast Cancer	2014 May	Tokunaga E	doi: 10.1007/s12282-012-0398-2
23065261	Prognostic impact of Metadherin-SND1 interaction in colon cancer.	Mol Biol Rep	2012 Dec	Wang N	doi: 10.1007/s11033-012-1933-0
24495449	MTDH/AEG-1 contributes to central features of the neoplastic phenotype in bladder cancer.	Urol Oncol	2014 Jul	Nikpour M	doi: 10.1016/j.urolonc.2013.11.005
25794773	MiR-153 inhibits epithelial-mesenchymal transition by targeting metadherin in human breast cancer.	Breast Cancer Res Treat	2015 Apr	Li W	doi: 10.1007/s10549-015-3346-y
22204714	Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression.	Hum Pathol	2012 Jul	Sun S	doi: 10.1016/j.humpath.2011.08.017
26236947	AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.	FEBS J	2015 Oct	Gollavilli PN	doi: 10.1111/febs.13391
25346496	Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.	Int J Cancer	2015 May 15	Haug S	doi: 10.1002/ijc.29289
25417825	MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NF??B-dependent pathway.	BMC Cancer	2014 Nov 24	Du C	doi: 10.1186/1471-2407-14-869.
26318406	High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.	J Biomol Screen	2016 Jan	Li C	doi: 10.1177/1087057115603310
25323629	microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer.	Mol Med Rep	2015 Jan	Tang Y	doi: 10.3892/mmr.2014.2682
26351209	AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer.	Oncol Res	2014	Li C	doi: 10.3727/096504015X14386062091352.
22938468	Deregulation of MTDH gene expression in gastric cancer.	Asian Pac J Cancer Prev	2012	Baygi ME	-
25684730	Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.	Mol Med Rep	2015 Jul	Wei YB	doi: 10.3892/mmr.2015.3357
25913216	The expression of astrocyte elevated gene-1 in human non-small-cell lung cancer and its relationship with postoperative chemotherapy and radiotherapy.	Histopathology	2015 Dec	Lu S	doi: 10.1111/his.12720
17563745	Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity.	Oncogene	2007 Dec 6	Kikuno N	-
19633686	Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1.	Oncogene	2009 Sep 10	Li J	doi: 10.1038/onc.2009.171
15093543	Metadherin, a cell surface protein in breast tumors that mediates lung metastasis.	Cancer Cell	2004 Apr	Brown DM	-
25074613	Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.	Cancer Res	2014 Sep 15	Wan L	doi: 10.1158/0008-5472.CAN-14-1349
21408129	Identification of novel variants of metadherin in breast cancer.	PLoS One	2011 Mar 8	Liu X	doi: 10.1371/journal.pone.0017582.
20565850	Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue.	Diagn Pathol	2010 Jun 18	Su P	doi: 10.1186/1746-1596-5-38.
20300973	Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer.	Med Oncol	2011 Jun	Jian-bo X	doi: 10.1007/s12032-010-9475-6
25092897	Uncontrolled inflammation induced by AEG-1 promotes gastric cancer and poor prognosis.	Cancer Res	2014 Oct 1	Li G	doi: 10.1158/0008-5472.CAN-14-0968
22372608	Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma.	Histopathology	2012 May	Li C	doi: 10.1111/j.1365-2559.2012.04182.x
25824750	Overexpression of astrocyte elevated gene-1 (AEG-1) in cervical cancer and its correlation with angiogenesis.	Asian Pac J Cancer Prev	2015	Yu JQ	-
26418251	Astrocyte elevated gene-1 increases invasiveness of NSCLC through up-regulating MMP7.	Cell Physiol Biochem	2015	Zhu R	doi: 10.1159/000430242
23307243	AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis.	Med Oncol	2013 Mar	Ke ZF	doi: 10.1007/s12032-012-0383-9
26141861	Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.	Cancer Res	2015 Sep 1	Liang Y	doi: 10.1158/0008-5472.CAN-15-0930
21543927	AEG -1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers.	Int J Gynecol Cancer	2011 May	Li C	doi: 10.1097/IGC.0b013e3182145561.
23889987	AEG-1/MTDH/LYRIC: clinical significance.	Adv Cancer Res	2013	Sarkar D	doi: 10.1016/B978-0-12-401676-7.00002-4.
21127263	Astrocyte elevated gene-1 induces protective autophagy.	Proc Natl Acad Sci U S A	2010 Dec 21	Bhutia SK	doi: 10.1073/pnas.1009479107
22056881	MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo.	Oncogene	2012 Jul 12	He XX	doi: 10.1038/onc.2011.500
18519759	Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival.	Clin Cancer Res	2008 Jun 1	Li J	doi: 10.1158/1078-0432.CCR-07-4054.
25902416	Knockdown of metadherin inhibits angiogenesis in breast cancer.	Int J Oncol	2015	Liu Y	doi: 10.3892/ijo.2015.2973
28107197	MTDH promotes glioma invasion through regulating miR-130b-ceRNAs.	Oncotarget	2017 Mar 14	Tong L	doi: 10.18632/oncotarget.14717.
27229534	MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin.	Oncotarget	2016 Jun 21	Yu J	doi: 10.18632/oncotarget.9572.
27835571	AEG-1 knockdown in colon cancer cell lines inhibits radiation-enhanced migration and invasion in vitro and in a novel in vivo zebrafish model.	Oncotarget	2016 Dec 6	Gnosa S	doi: 10.18632/oncotarget.13155.
27090750	Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND.	Prog Neurobiol	2017 Oct	Vartak-Sharma N	doi: 10.1016/j.pneurobio.2016.03.006
28627585	Role of metadherin in estrogen-regulated gene expression.	Int J Mol Med	2017 Aug	Li Y	doi: 10.3892/ijmm.2017.3020
27917902	Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.	Sci Rep	2016 Dec 5	Hou Y	doi: 10.1038/srep38365.
28923415	Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).	Cell Signal	2017 Dec	Draz H	doi: 10.1016/j.cellsig.2017.09.006
28938524	MicroRNA-384 represses the growth and invasion of non-small-cell lung cancer by targeting astrocyte elevated gene-1/Wnt signaling.	Biomed Pharmacother	2017 Nov	Fan N	doi: 10.1016/j.biopha.2017.08.143
28661037	AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression.	J Cell Mol Med	2017 Dec	Wu S	doi: 10.1111/jcmm.13258
28534938	Metadherin regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition.	Int J Oncol	2017 Jul	Du Y	doi: 10.3892/ijo.2017.4002
29257267	miR96 inhibits EMT by targeting AEG1 in glioblastoma cancer cells.	Mol Med Rep	2018 Feb	Feng S	doi: 10.3892/mmr.2017.8227
29770329	AEG-1 Contributes to Metastasis in Hypoxia-Related Ovarian Cancer by Modulating the HIF-1alpha/NF-kappaB/VEGF Pathway.	Biomed Res Int	2018 Mar 25	Yu X	doi: 10.1155/2018/3145689
29562498	MicroRNA-136 functions as a tumor suppressor in osteosarcoma via regulating metadherin.	Cancer Biomark	2018	Guo T	doi: 10.3233/CBM-170970.
29558717	MicroRNA-625-3p promotes the proliferation, migration and invasion of thyroid cancer cells by up-regulating astrocyte elevated gene 1.	Biomed Pharmacother	2018 Jun	Fang L	doi: 10.1016/j.biopha.2018.03.043
30015962	Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer.	Oncol Rep	2018 Oct	Li JW	doi: 10.3892/or.2018.6581
30359541	Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration, and invasiveness, and promotes apoptosis in pancreatic cancer cells.	Biochem Cell Biol	2019 Apr	Yang X	doi: 10.1139/bcb-2018-0181
29117631	Astrocyte elevated gene-1 promotes invasion and epithelial-mesenchymal transition in bladder cancer cells through activation of signal transducer and activator of transcription 3.	Int J Urol	2018 Feb	Yang X	doi: 10.1111/iju.13486

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	97706716	Missense_Mutation	novel	L413R	0.09
BLCA	chr8	97691011	Missense_Mutation	NA	V291L	0.07
BLCA	chr8	97719077	Missense_Mutation	novel	R470T	0.47
BLCA	chr8	97699792	Missense_Mutation	NA	D363H	0.12
BLCA	chr8	97706710	Nonsense_Mutation	novel	S411*	0.14
BLCA	chr8	97691084	Missense_Mutation	novel	R315T	0.32
BRCA	chr8	97724662	Missense_Mutation	NA	E581K	0.24
BRCA	chr8	97691075	Missense_Mutation	novel	A312V	0.07
BRCA	chr8	97661158	Missense_Mutation	novel	D156E	0.11
BRCA	chr8	97724728	3'UTR	novel		0.08
CESC	chr8	97699765	Missense_Mutation	NA	E354K	0.17
CESC	chr8	97689041	Frame_Shift_Del	novel	*D250Efs20**	0.16
CESC	chr8	97725990	3'UTR	novel		0.4
CESC	chr8	97722983	Silent	novel	E542E	0.25
CESC	chr8	97723034	Missense_Mutation	NA	Q559H	0.1
CESC	chr8	97699765	Missense_Mutation	NA	E354K	0.21
CESC	chr8	97687572	Missense_Mutation	novel	A238T	0.32
CESC	chr8	97724662	Nonsense_Mutation	novel	E581*	0.21
CESC	chr8	97726238	3'UTR	novel		0.49
CESC	chr8	97644636	Missense_Mutation	novel	P44S	0.48
CESC	chr8	97725573	3'UTR	novel		0.23
CESC	chr8	97687501	Missense_Mutation	NA	S214C	0.18
COAD	chr8	97689081	Frame_Shift_Del	novel	*G265Efs11**	0.27
COAD	chr8	97691034	Silent	NA	S298S	0.38
COAD	chr8	97699775	Missense_Mutation	NA	S357Y	0.34
COAD	chr8	97687512	Missense_Mutation	novel	D218H	0.15
COAD	chr8	97661114	Nonsense_Mutation	rs770905188	R142*	0.39
COAD	chr8	97724673	3'UTR	novel		0.28
COAD	chr8	97661171	Missense_Mutation	novel	K161E	0.36
COAD	chr8	97724637	Frame_Shift_Del	novel	*K574Rfs33**	0.49
COAD	chr8	97723006	Missense_Mutation	novel	T550S	0.64
COAD	chr8	97719106	Missense_Mutation	novel	T480P	0.17
COAD	chr8	97713666	Nonsense_Mutation	NA	S426*	0.56
COAD	chr8	97719175	Missense_Mutation	rs368307370	V503I	0.13
COAD	chr8	97719178	Frame_Shift_Del	NA	*N505Ifs18**	0.48
COAD	chr8	97713722	Frame_Shift_Del	NA	*K447Rfs19**	0.29
COAD	chr8	97661081	Missense_Mutation	rs758753771	R131W	0.09
COAD	chr8	97689044	Missense_Mutation	NA	S251Y	0.1
COAD	chr8	97719086	Missense_Mutation	novel	L473R	0.22
COAD	chr8	97723006	Missense_Mutation	NA	T550I	0.14
COAD	chr8	97724675	3'UTR	novel		0.13
ESCA	chr8	97725027	3'UTR	novel		0.11
ESCA	chr8	97724877	3'UTR	novel		0.14
GBM	chr8	97723015	Missense_Mutation	NA	N553S	0.33
GBM	chr8	97644612	Silent	novel	L36L	0.24
GBM	chr8	97644784	Missense_Mutation	rs754496543	A93V	0.57
GBM	chr8	97691177	Missense_Mutation	novel	F346C	0.04
GBM	chr8	97719110	Missense_Mutation	rs143317071	R481H	0.46
HNSC	chr8	97723010	Missense_Mutation	novel	K551N	0.24
HNSC	chr8	97691096	Missense_Mutation	novel	P319L	0.18
HNSC	chr8	97644799	Missense_Mutation	novel	A98V	0.54
HNSC	chr8	97719189	Missense_Mutation	novel	Q507H	0.32
HNSC	chr8	97719110	Missense_Mutation	rs143317071	R481H	0.24
KIRC	chr8	97713761	Missense_Mutation	novel	T458P	0.57
KIRC	chr8	97713762	Missense_Mutation	novel	T458I	0.57
KIRC	chr8	97690979	Missense_Mutation	NA	T280S	0.19
KIRC	chr8	97719153	Silent	novel	T495T	0.37
KIRC	chr8	97691172	Silent	NA	S344S	0.22
KIRP	chr8	97713745	Frame_Shift_Ins	novel	*G453Mfs14**	0.15
KIRP	chr8	97713746	Frame_Shift_Ins	novel	*E454Yfs14**	0.15
LGG	chr8	97722919	Missense_Mutation	novel	S521Y	0.1
LUAD	chr8	97722931	Missense_Mutation	novel	S525L	0.25
LUAD	chr8	97661091	Frame_Shift_Del	novel	*E134Vfs12**	0.32
LUAD	chr8	97706640	Missense_Mutation	novel	A388S	0.17
LUSC	chr8	97661161	Missense_Mutation	novel	K157N	0.19
LUSC	chr8	97644524	Nonsense_Mutation	novel	W6*	0.13
LUSC	chr8	97644499	5'UTR	novel		0.3
LUSC	chr8	97722898	Missense_Mutation	novel	P514L	0.28
LUSC	chr8	97691002	Missense_Mutation	novel	E288K	0.21
LUSC	chr8	97644552	Missense_Mutation	novel	E16K	0.15
LUSC	chr8	97699759	Missense_Mutation	rs756601591	T352A	0.34
LUSC	chr8	97719055	Missense_Mutation	NA	E463K	0.12
LUSC	chr8	97724816	3'UTR	novel		0.25
LUSC	chr8	97691146	Missense_Mutation	NA	W336R	0.08
OV	chr8	97713721	Missense_Mutation	novel	K444N	0.09
PRAD	chr8	97644872	Silent	NA	L122L	0.31
PRAD	chr8	97699800	Missense_Mutation	novel	Q365H	0.38
PRAD	chr8	97724620	Missense_Mutation	novel	E567Q	0.13
READ	chr8	97719110	Missense_Mutation	rs143317071	R481H	0.3
READ	chr8	97713722	Frame_Shift_Del	NA	*K447Rfs19**	0.33
READ	chr8	97706715	Missense_Mutation	novel	L413I	0.39
SKCM	chr8	97719134	Missense_Mutation	rs779250302	S489F	0.42
SKCM	chr8	97644802	Missense_Mutation	NA	A99V	0.36
SKCM	chr8	97644803	Silent	novel	A99A	0.36
SKCM	chr8	97691106	Nonsense_Mutation	NA	W322*	0.43
SKCM	chr8	97691057	Missense_Mutation	NA	S306F	0.16
SKCM	chr8	97691058	Silent	rs142598802	S306S	0.11
SKCM	chr8	97719048	Splice_Site	novel	X461_splice	0.26
SKCM	chr8	97722960	Nonsense_Mutation	NA	Q535*	0.75
SKCM	chr8	97724626	Missense_Mutation	novel	P569S	0.37
STAD	chr8	97724673	3'UTR	novel		0.32
STAD	chr8	97691131	Missense_Mutation	NA	T331A	0.29
STAD	chr8	97691010	Frame_Shift_Del	novel	*V291Kfs10**	0.27
STAD	chr8	97699783	Missense_Mutation	novel	T360P	0.21
STAD	chr8	97724673	3'UTR	novel		0.26
STAD	chr8	97687465	Missense_Mutation	NA	R202Q	0.09
STAD	chr8	97644784	Missense_Mutation	rs754496543	A93V	0.47
STAD	chr8	97687479	Missense_Mutation	NA	R207C	0.23
THCA	chr8	97713745	Frame_Shift_Ins	novel	*G453Mfs14**	0.12
THCA	chr8	97713746	Frame_Shift_Ins	novel	*E454Yfs3**	0.12
THYM	chr8	97724970	3'UTR	novel		0.05
UCEC	chr8	97725929	3'UTR	novel		0.5
UCEC	chr8	97722952	Missense_Mutation	novel	S532I	0.33
UCEC	chr8	97722980	Missense_Mutation	NA	Q541H	0.56
UCEC	chr8	97724812	3'UTR	novel		0.29
UCEC	chr8	97726244	3'UTR	novel		0.41
UCEC	chr8	97689044	Missense_Mutation	NA	S251Y	0.05
UCEC	chr8	97719153	Silent	novel	T495T	0.47
UCEC	chr8	97691095	Missense_Mutation	novel	P319S	0.36
UCEC	chr8	97726268	3'UTR	novel		0.34
UCEC	chr8	97726399	3'UTR	novel		0.42
UCEC	chr8	97691054	Missense_Mutation	NA	N305S	0.24
UCEC	chr8	97713664	Splice_Region	novel	V425V	0.08
UCEC	chr8	97725849	3'UTR	novel		0.48
UCEC	chr8	97699801	Missense_Mutation	NA	W366R	0.22
UCEC	chr8	97722915	Missense_Mutation	NA	P520S	0.19
UCEC	chr8	97719057	Missense_Mutation	novel	E463D	0.16
UCEC	chr8	97691127	Silent	novel	A329A	0.18
UCEC	chr8	97706751	Splice_Site	novel	X424_splice	0.22
UCEC	chr8	97687490	Silent	novel	V210V	0.28
UCEC	chr8	97725657	3'UTR	novel		0.31
UCEC	chr8	97725957	3'UTR	novel		0.38
UCEC	chr8	97722894	Frame_Shift_Del	novel	*P513Hfs10**	0.32
UCEC	chr8	97724719	3'UTR	novel		0.34
UCEC	chr8	97724672	3'UTR	rs147469611		0.37
UCEC	chr8	97725685	3'UTR	novel		0.43
UCEC	chr8	97713721	Frame_Shift_Ins	novel	*K448Efs7**	0.42
UCEC	chr8	97689044	Missense_Mutation	NA	S251Y	0.19
UCEC	chr8	97719058	Nonsense_Mutation	novel	E464*	0.13
UCEC	chr8	97725716	3'UTR	novel		0.17
UCEC	chr8	97725979	3'UTR	novel		0.15
UCEC	chr8	97726397	3'UTR	novel		0.19
UCEC	chr8	97706709	Missense_Mutation	novel	S411P	0.23
UCEC	chr8	97726182	3'UTR	novel		0.07
UCEC	chr8	97725846	3'UTR	novel		0.26
UCEC	chr8	97644520	Missense_Mutation	novel	S5N	0.3
UCEC	chr8	97724671	3'UTR	novel		0.39
UCEC	chr8	97725694	3'UTR	novel		0.35
UCEC	chr8	97699775	Missense_Mutation	NA	S357Y	0.33
UCEC	chr8	97706733	Missense_Mutation	novel	I419L	0.19
UCEC	chr8	97706704	Missense_Mutation	novel	R409I	0.05
UCEC	chr8	97724837	3'UTR	novel		0.33
UCEC	chr8	97725403	3'UTR	novel		0.43
UCEC	chr8	97725597	3'UTR	novel		0.2
UCEC	chr8	97686724	Silent	novel	S180S	0.33
UCEC	chr8	97661077	Missense_Mutation	novel	N129K	0.37
UCEC	chr8	97687519	Missense_Mutation	novel	T220I	0.29
UCEC	chr8	97706704	Missense_Mutation	novel	R409I	0.14
UCEC	chr8	97689092	Missense_Mutation	NA	S267Y	0.45
UCEC	chr8	97724772	3'UTR	novel		0.46
UCEC	chr8	97724729	3'UTR	novel		0.31
UCEC	chr8	97719128	Missense_Mutation	NA	A487D	0.17
UCEC	chr8	97713722	Frame_Shift_Del	NA	*K447Rfs19**	0.32
UCEC	chr8	97725639	3'UTR	novel		0.38
UCEC	chr8	97713705	Missense_Mutation	novel	T439I	0.46
UCEC	chr8	97725128	3'UTR	novel		0.42
UCEC	chr8	97724993	3'UTR	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.1023	0.15559
PRAD	AMP	0.2642	3.7005e-05
SARC	AMP	0.2802	0.18425
TGCT	AMP	0.66	0.13696
THCA	DEL	0.008	0.038162

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0049	Kaplan-Meier Survival Analysis
KIRC	0.019	Kaplan-Meier Survival Analysis
STAD	0.012	Kaplan-Meier Survival Analysis
MESO	0.048	Kaplan-Meier Survival Analysis
HNSC	0.023	Kaplan-Meier Survival Analysis
SKCM	0.0041	Kaplan-Meier Survival Analysis
LUSC	0.0045	Kaplan-Meier Survival Analysis
BRCA	0.00041	Kaplan-Meier Survival Analysis
KIRP	0.00016	Kaplan-Meier Survival Analysis
COAD	0.012	Kaplan-Meier Survival Analysis
PAAD	0.001	Kaplan-Meier Survival Analysis
CESC	0.019	Kaplan-Meier Survival Analysis
KICH	0.0043	Kaplan-Meier Survival Analysis
LIHC	0.04	Kaplan-Meier Survival Analysis
LGG	0.0073	Kaplan-Meier Survival Analysis
LUAD	0.014	Kaplan-Meier Survival Analysis
UVM	0.0026	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000147649 (Gene tree)
Gene ID: 92140
Gene Symbol: MTDH
Alias: LYRIC|3D3|AEG-1
Full Name: metadherin
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 86,114 bases
Position: chr8:97,644,147-97,730,260
Accession: 29608
Summary: (Metadherin) is a Protein Coding gene. Diseases associated with MTDH include Gallbladder Adenocarcinoma and External Ear Disease. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is MAMSTR.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22199357	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	J Biol Chem	2012 Feb 10	Meng X	doi: 10.1074/jbc.C111.291518
29438049	Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs.	RNA	2018 May	Hsu JC	doi: 10.1261/rna.063313.117
25787750	A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway.	Tumour Biol	2015 Aug	Li C	doi: 10.1007/s13277-015-3314-5
23889990	Drug resistance mediated by AEG-1/MTDH/LYRIC.	Adv Cancer Res	2013	Meng X	doi: 10.1016/B978-0-12-401676-7.00005-X.
28634830	The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.	Arch Dermatol Res	2017 Sep	Hessam S	doi: 10.1007/s00403-017-1752-1
30588098	Clinical significance and effect of MTDH/AEG-1 in bladder urothelial cancer: a study based on immunohistochemistry, RNA-seq, and in vitro verification.	Cancer Manag Res	2018 Dec 14	Zhang Y	doi: 10.2147/CMAR.S176887

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000519934	MTDH-203	2184	XM_005251099	ENSP00000428168	526 (aa)	XP_016869457	E5RJU9
ENST00000522104	MTDH-205	486	-	-	- (aa)	-	-
ENST00000519293	MTDH-202	629	-	ENSP00000429289	60 (aa)	-	H0YBE0
ENST00000521933	MTDH-204	565	-	ENSP00000429642	188 (aa)	-	H0YBJ8
ENST00000336273	MTDH-201	6177	XM_011517367	ENSP00000338235	582 (aa)	XP_011515670	Q86UE4
ENST00000522313	MTDH-206	672	-	ENSP00000428703	224 (aa)	-	H0YB56

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000147649	Platelet Function Tests	2.4367200E-005	-
ENSG00000147649	Platelet Function Tests	3.6370200E-005	-
ENSG00000147649	Platelet Function Tests	2.6556900E-005	-
ENSG00000147649	Platelet Function Tests	2.4367200E-005	-
ENSG00000147649	Platelet Function Tests	3.6370200E-005	-
ENSG00000147649	Platelet Function Tests	2.6556900E-005	-
ENSG00000147649	Platelet Function Tests	1.3747600E-005	-
ENSG00000147649	Platelet Function Tests	1.4674900E-005	-
ENSG00000147649	Platelet Function Tests	1.5596500E-005	-
ENSG00000147649	Platelet Function Tests	1.7476900E-005	-
ENSG00000147649	Platelet Function Tests	5.7300000E-006	-
ENSG00000147649	Platelet Function Tests	4.0700000E-006	-
ENSG00000147649	Platelet Function Tests	4.6000000E-006	-
ENSG00000147649	Platelet Function Tests	4.9200000E-006	-
ENSG00000147649	Platelet Function Tests	4.4600000E-006	-
ENSG00000147649	Platelet Function Tests	4.8400000E-006	-
ENSG00000147649	Platelet Function Tests	6.4200000E-006	-
ENSG00000147649	Platelet Function Tests	6.0200000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000147649	rs149211171	8	97708529	?	Mean corpuscular hemoglobin	29403010	[0.017-0.036] unit increase novel	0.02684	EFO_0004527
ENSG00000147649	rs2468024	8	97652425	A	Red cell distribution width	28957414	[0.057-0.088] unit decrease	0.0721306	EFO_0005192
ENSG00000147649	rs2449511	8	97723714	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000147649	rs2468024	8	97652425	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147649's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000147649	MTDH	100	91.065	ENSMUSG00000022255	Mtdh	100	90.722	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	15927426.	IDA	Process
GO:0001085	RNA polymerase II transcription factor binding	21873635.	IBA	Function
GO:0001085	RNA polymerase II transcription factor binding	18316612.	IPI	Function
GO:0001650	fibrillar center	-	IDA	Component
GO:0003713	transcription coactivator activity	18316612.	IMP	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0005515	protein binding	18316612.18440304.19433866.19648967.24981741.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	16452207.	IDA	Component
GO:0005737	cytoplasm	19648967.	IDA	Component
GO:0005783	endoplasmic reticulum	14980505.15927426.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	ISS	Component
GO:0005923	bicellular tight junction	-	ISS	Component
GO:0010508	positive regulation of autophagy	21127263.	IDA	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016324	apical plasma membrane	-	ISS	Component
GO:0016604	nuclear body	19648967.	IDA	Component
GO:0031663	lipopolysaccharide-mediated signaling pathway	19740331.	IMP	Process
GO:0031965	nuclear membrane	-	IEA	Component
GO:0043066	negative regulation of apoptotic process	17704808.	IDA	Process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	16452207.18316612.	IDA	Process
GO:0045766	positive regulation of angiogenesis	19940250.	IDA	Process
GO:0046581	intercellular canaliculus	-	ISS	Component
GO:0048471	perinuclear region of cytoplasm	14980505.15927426.	IDA	Component
GO:0051059	NF-kappaB binding	21873635.	IBA	Function
GO:0051059	NF-kappaB binding	16452207.	IPI	Function
GO:0051092	positive regulation of NF-kappaB transcription factor activity	16452207.18316612.	IDA	Process
GO:0051897	positive regulation of protein kinase B signaling	17704808.	IDA	Process
GO:0070830	bicellular tight junction assembly	-	IEA	Process
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.