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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23408429The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer.J Biol Chem2013 Mar 29Zhang Ndoi: 10.1074/jbc.M112.395913
24829140AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer.Med Oncol2014 JunYang Gdoi: 10.1007/s12032-014-0986-4
27793010Elevated AEG-1 expression in macrophages promotes hypopharyngeal cancer invasion through the STAT3-MMP-9 signaling pathway.Oncotarget2016 Nov 22Liu Xdoi: 10.18632/oncotarget.12886.
21495225Expression of astrocyte elevated gene-1: a novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer.Int J Gynecol Cancer2010 OctSong H-
21259255Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer.J Surg Oncol2011 FebLi Cdoi: 10.1002/jso.21788
26710214Astrocyte Elevated Gene-1 as a Novel Clinicopathological and Prognostic Biomarker for Gastrointestinal Cancers: A Meta-Analysis with 2999 Patients.PLoS One2015 Dec 28Luo Ydoi: 10.1371/journal.pone.0145659
25432696MicroRNA-542-3p suppresses cell growth of gastric cancer cells via targeting oncogene astrocyte-elevated gene-1.Med Oncol2015 JanShen Xdoi: 10.1007/s12032-014-0361-5
29048632MicroRNA-1297 inhibits metastasis and epithelial-mesenchymal transition by targeting AEG-1 in cervical cancer.Oncol Rep2017 NovWang Zdoi: 10.3892/or.2017.5979
28941723AEG-1 mRNA expression in non-small cell lung cancer is associated with increased tumor angiogenesis.Pathol Res Pract2017 OctMa Zdoi: 10.1016/j.prp.2017.09.003
29207012MicroRNA30a5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway.Int J Mol Med2018 FebLi Jdoi: 10.3892/ijmm.2017.3269
29478367MicroRNA-30a Mediates Cell Migration and Invasion by Targeting Metadherin in Colorectal Cancer.Technol Cancer Res Treat2018 Jan 1Jin Hdoi: 10.1177/1533033818758108.
20625905Prognostic significance of AEG-1 expression in colorectal carcinoma.Int J Colorectal Dis2010 OctSong Hdoi: 10.1007/s00384-010-1009-3
25193383Genetic deletion of AEG-1 prevents hepatocarcinogenesis.Cancer Res2014 Nov 1Robertson CLdoi: 10.1158/0008-5472.CAN-14-1357
25182604Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival.J Neurooncol2015 JanPark KJdoi: 10.1007/s11060-014-1603-2
24119914Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis.J Pediatr Urol2014 AprGuo Fdoi: 10.1016/j.jpurol.2013.09.010
22967897MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2.FEBS Lett2012 Oct 19Yang Ydoi: 10.1016/j.febslet.2012.08.003
22195048Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells.PLoS One2011Zhao Ydoi: 10.1371/journal.pone.0029363
20388776Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion.Cancer Res2010 May 1Liu Ldoi: 10.1158/0008-5472.CAN-09-3838
27667169AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells.Oncol Rep2016 NovPark SYdoi: 10.3892/or.2016.5106
20845990Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression.Neoplasma2010Chen W-
24656097Expression of AEG-1 and microvessel density correlates with metastasis and prognosis of oral squamous cell carcinoma.Hum Pathol2014 AprXia Xdoi: 10.1016/j.humpath.2013.08.030
26589417Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway.Tumour Biol2016 MayLi WFdoi: 10.1007/s13277-015-4456-1
23851509MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin.Oncogene2014 Jun 12Zhang Ndoi: 10.1038/onc.2013.286
27339400Tetraspanin 8 mediates AEG-1-induced invasion and metastasis in hepatocellular carcinoma cells.FEBS Lett2016 AugAkiel MAdoi: 10.1002/1873-3468.12268
26096243Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms.Niger J Clin Pract2015 Sep-OctErdem Hdoi: 10.4103/1119-3077.158961.
29315995MicroRNA-1271 suppresses the proliferation and invasion of colorectal cancer cells by regulating metadherin/Wnt signaling.J Biochem Mol Toxicol2018 FebSun Xdoi: 10.1002/jbt.22028
29152659MicroRNA216b inhibits cell proliferation and invasion in glioma by directly targeting metadherin.Mol Med Rep2017 DecChen Zdoi: 10.3892/mmr.2017.7829
29286115MicroRNA-379 inhibits cell proliferation and invasion in glioma via targeting metadherin and regulating PTEN/AKT pathway.Mol Med Rep2018 MarLi Ldoi: 10.3892/mmr.2017.8361
23240043The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility.PLoS One2012Yuan Cdoi: 10.1371/journal.pone.0051561
23595222Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-??B pathway.Tumour Biol2013 AugZhang Jdoi: 10.1007/s13277-013-0794-z
22367022Metadherin regulates radioresistance in cervical cancer cells.Oncol Rep2012 MayZhao Ydoi: 10.3892/or.2012.1692
26156805The key role of astrocyte elevated gene-1 in CCR6-induced EMT in cervical cancer.Tumour Biol2015 DecZhang Jdoi: 10.1007/s13277-015-3760-0
22898150Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival.Asia Pac J Clin Oncol2012 SepZhou Jdoi: 10.1111/j.1743-7563.2012.01541.x
26122237PROTEIN EXPRESSION OF METADHERIN AND SENSIBILITY OF BREAST CANCER MDA-MB-231 CELLS TO TREATMENT BEFORE AND AFTER TRANSFECTION.J Biol Regul Homeost Agents2015 Apr-JunZhao H-
25483832Overexpression of astrocyte-elevated gene-1 is associated with ovarian cancer development and progression.Mol Med Rep2015 AprZhou Bdoi: 10.3892/mmr.2014.3056
28323000Knockdown of astrocyte elevated gene-1 inhibited cell growth and induced apoptosis and suppressed invasion in ovarian cancer cells.Gene2017 Jun 15Wang Jdoi: 10.1016/j.gene.2017.03.024
27746178MicroRNA-1297 inhibits prostate cancer cell proliferation and invasion by targeting the AEG-1/Wnt signaling pathway.Biochem Biophys Res Commun2016 Nov 11Liang Xdoi: 10.1016/j.bbrc.2016.10.029
28401704HIF-1α binding to AEG-1 promoter induced upregulated AEG-1 expression associated with metastasis in ovarian cancer.Cancer Med2017 MayZhao Tdoi: 10.1002/cam4.1053
28731152AEG-1 associates with metastasis in papillary thyroid cancer through upregulation of MMP2/9.Int J Oncol2017 SepHuang LLdoi: 10.3892/ijo.2017.4074
29115517MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin.Mol Med Rep2018 JanLiao Zdoi: 10.3892/mmr.2017.7908
23889989Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer.Adv Cancer Res2013Wan Ldoi: 10.1016/B978-0-12-401676-7.00004-8.
22246354[Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue].Zhong Nan Da Xue Xue Bao Yi Xue Ban2011 DecDeng Ndoi: 10.3969/j.issn.1672-7347.2011.12.012.
25652471Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway.Tumour Biol2015 JulZou Ydoi: 10.1007/s13277-015-3174-z
25431427RNA interference-mediated knockdown of astrocyte elevated gene-1 inhibits growth, induces apoptosis, and increases the chemosensitivity to 5-fluorouracil in renal cancer Caki-1 cells.Mol Cells2014 Dec 31Wang Pdoi: 10.14348/molcells.2014.0081
24675891Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance.Cell Cycle2014Liu Xdoi: 10.4161/cc.28607
22643064Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines.J Transl Med2012 May 29Gnosa Sdoi: 10.1186/1479-5876-10-109.
22351252Clinical implications of AEG-1 in liver metastasis of colorectal cancer.Med Oncol2012 DecJiang Tdoi: 10.1007/s12032-012-0186-z
22340175Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression.Chin Med J (Engl)2011 NovZhang X-
21371176Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition.Cancer Sci2011 JunLi Xdoi: 10.1111/j.1349-7006.2011.01919.x
19383828LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals.Clin Cancer Res2009 May 1Thirkettle HJdoi: 10.1158/1078-0432.CCR-08-2046
22903204Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.Breast Cancer2014 MayTokunaga Edoi: 10.1007/s12282-012-0398-2
23065261Prognostic impact of Metadherin-SND1 interaction in colon cancer.Mol Biol Rep2012 DecWang Ndoi: 10.1007/s11033-012-1933-0
24495449MTDH/AEG-1 contributes to central features of the neoplastic phenotype in bladder cancer.Urol Oncol2014 JulNikpour Mdoi: 10.1016/j.urolonc.2013.11.005
25794773MiR-153 inhibits epithelial-mesenchymal transition by targeting metadherin in human breast cancer.Breast Cancer Res Treat2015 AprLi Wdoi: 10.1007/s10549-015-3346-y
22204714Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression.Hum Pathol2012 JulSun Sdoi: 10.1016/j.humpath.2011.08.017
26236947AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.FEBS J2015 OctGollavilli PNdoi: 10.1111/febs.13391
25346496Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.Int J Cancer2015 May 15Haug Sdoi: 10.1002/ijc.29289
25417825MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NF??B-dependent pathway.BMC Cancer2014 Nov 24Du Cdoi: 10.1186/1471-2407-14-869.
26318406High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.J Biomol Screen2016 JanLi Cdoi: 10.1177/1087057115603310
25323629microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer.Mol Med Rep2015 JanTang Ydoi: 10.3892/mmr.2014.2682
26351209AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer.Oncol Res2014Li Cdoi: 10.3727/096504015X14386062091352.
22938468Deregulation of MTDH gene expression in gastric cancer.Asian Pac J Cancer Prev2012Baygi ME-
25684730Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.Mol Med Rep2015 JulWei YBdoi: 10.3892/mmr.2015.3357
25913216The expression of astrocyte elevated gene-1 in human non-small-cell lung cancer and its relationship with postoperative chemotherapy and radiotherapy.Histopathology2015 DecLu Sdoi: 10.1111/his.12720
17563745Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity.Oncogene2007 Dec 6Kikuno N-
19633686Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1.Oncogene2009 Sep 10Li Jdoi: 10.1038/onc.2009.171
15093543Metadherin, a cell surface protein in breast tumors that mediates lung metastasis.Cancer Cell2004 AprBrown DM-
25074613Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.Cancer Res2014 Sep 15Wan Ldoi: 10.1158/0008-5472.CAN-14-1349
21408129Identification of novel variants of metadherin in breast cancer.PLoS One2011 Mar 8Liu Xdoi: 10.1371/journal.pone.0017582.
20565850Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue.Diagn Pathol2010 Jun 18Su Pdoi: 10.1186/1746-1596-5-38.
20300973Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer.Med Oncol2011 JunJian-bo Xdoi: 10.1007/s12032-010-9475-6
25092897Uncontrolled inflammation induced by AEG-1 promotes gastric cancer and poor prognosis.Cancer Res2014 Oct 1Li Gdoi: 10.1158/0008-5472.CAN-14-0968
22372608Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma.Histopathology2012 MayLi Cdoi: 10.1111/j.1365-2559.2012.04182.x
25824750Overexpression of astrocyte elevated gene-1 (AEG-1) in cervical cancer and its correlation with angiogenesis.Asian Pac J Cancer Prev2015Yu JQ-
26418251Astrocyte elevated gene-1 increases invasiveness of NSCLC through up-regulating MMP7.Cell Physiol Biochem2015Zhu Rdoi: 10.1159/000430242
23307243AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis.Med Oncol2013 MarKe ZFdoi: 10.1007/s12032-012-0383-9
26141861Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.Cancer Res2015 Sep 1Liang Ydoi: 10.1158/0008-5472.CAN-15-0930
21543927AEG -1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers.Int J Gynecol Cancer2011 MayLi Cdoi: 10.1097/IGC.0b013e3182145561.
23889987AEG-1/MTDH/LYRIC: clinical significance.Adv Cancer Res2013Sarkar Ddoi: 10.1016/B978-0-12-401676-7.00002-4.
21127263Astrocyte elevated gene-1 induces protective autophagy.Proc Natl Acad Sci U S A2010 Dec 21Bhutia SKdoi: 10.1073/pnas.1009479107
22056881MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo.Oncogene2012 Jul 12He XXdoi: 10.1038/onc.2011.500
18519759Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival.Clin Cancer Res2008 Jun 1Li Jdoi: 10.1158/1078-0432.CCR-07-4054.
25902416Knockdown of metadherin inhibits angiogenesis in breast cancer.Int J Oncol2015Liu Ydoi: 10.3892/ijo.2015.2973
28107197MTDH promotes glioma invasion through regulating miR-130b-ceRNAs.Oncotarget2017 Mar 14Tong Ldoi: 10.18632/oncotarget.14717.
27229534MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin.Oncotarget2016 Jun 21Yu Jdoi: 10.18632/oncotarget.9572.
27835571AEG-1 knockdown in colon cancer cell lines inhibits radiation-enhanced migration and invasion in vitro and in a novel in vivo zebrafish model.Oncotarget2016 Dec 6Gnosa Sdoi: 10.18632/oncotarget.13155.
27090750Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND.Prog Neurobiol2017 OctVartak-Sharma Ndoi: 10.1016/j.pneurobio.2016.03.006
28627585Role of metadherin in estrogen-regulated gene expression.Int J Mol Med2017 AugLi Ydoi: 10.3892/ijmm.2017.3020
27917902Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.Sci Rep2016 Dec 5Hou Ydoi: 10.1038/srep38365.
28923415Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).Cell Signal2017 DecDraz Hdoi: 10.1016/j.cellsig.2017.09.006
28938524MicroRNA-384 represses the growth and invasion of non-small-cell lung cancer by targeting astrocyte elevated gene-1/Wnt signaling.Biomed Pharmacother2017 NovFan Ndoi: 10.1016/j.biopha.2017.08.143
28661037AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression.J Cell Mol Med2017 DecWu Sdoi: 10.1111/jcmm.13258
28534938Metadherin regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition.Int J Oncol2017 JulDu Ydoi: 10.3892/ijo.2017.4002
29257267miR96 inhibits EMT by targeting AEG1 in glioblastoma cancer cells.Mol Med Rep2018 FebFeng Sdoi: 10.3892/mmr.2017.8227
29770329AEG-1 Contributes to Metastasis in Hypoxia-Related Ovarian Cancer by Modulating the HIF-1alpha/NF-kappaB/VEGF Pathway.Biomed Res Int2018 Mar 25Yu Xdoi: 10.1155/2018/3145689
29562498MicroRNA-136 functions as a tumor suppressor in osteosarcoma via regulating metadherin.Cancer Biomark2018Guo Tdoi: 10.3233/CBM-170970.
29558717MicroRNA-625-3p promotes the proliferation, migration and invasion of thyroid cancer cells by up-regulating astrocyte elevated gene 1.Biomed Pharmacother2018 JunFang Ldoi: 10.1016/j.biopha.2018.03.043
30015962Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer.Oncol Rep2018 OctLi JWdoi: 10.3892/or.2018.6581
30359541Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration, and invasiveness, and promotes apoptosis in pancreatic cancer cells.Biochem Cell Biol2019 AprYang Xdoi: 10.1139/bcb-2018-0181
29117631Astrocyte elevated gene-1 promotes invasion and epithelial-mesenchymal transition in bladder cancer cells through activation of signal transducer and activator of transcription 3.Int J Urol2018 FebYang Xdoi: 10.1111/iju.13486

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr897706716Missense_MutationnovelL413R0.09
BLCAchr897691011Missense_MutationNAV291L0.07
BLCAchr897719077Missense_MutationnovelR470T0.47
BLCAchr897699792Missense_MutationNAD363H0.12
BLCAchr897706710Nonsense_MutationnovelS411*0.14
BLCAchr897691084Missense_MutationnovelR315T0.32
BRCAchr897724662Missense_MutationNAE581K0.24
BRCAchr897691075Missense_MutationnovelA312V0.07
BRCAchr897661158Missense_MutationnovelD156E0.11
BRCAchr8977247283'UTRnovel0.08
CESCchr897699765Missense_MutationNAE354K0.17
CESCchr897689041Frame_Shift_DelnovelD250Efs*200.16
CESCchr8977259903'UTRnovel0.4
CESCchr897722983SilentnovelE542E0.25
CESCchr897723034Missense_MutationNAQ559H0.1
CESCchr897699765Missense_MutationNAE354K0.21
CESCchr897687572Missense_MutationnovelA238T0.32
CESCchr897724662Nonsense_MutationnovelE581*0.21
CESCchr8977262383'UTRnovel0.49
CESCchr897644636Missense_MutationnovelP44S0.48
CESCchr8977255733'UTRnovel0.23
CESCchr897687501Missense_MutationNAS214C0.18
COADchr897689081Frame_Shift_DelnovelG265Efs*110.27
COADchr897691034SilentNAS298S0.38
COADchr897699775Missense_MutationNAS357Y0.34
COADchr897687512Missense_MutationnovelD218H0.15
COADchr897661114Nonsense_Mutationrs770905188R142*0.39
COADchr8977246733'UTRnovel0.28
COADchr897661171Missense_MutationnovelK161E0.36
COADchr897724637Frame_Shift_DelnovelK574Rfs*330.49
COADchr897723006Missense_MutationnovelT550S0.64
COADchr897719106Missense_MutationnovelT480P0.17
COADchr897713666Nonsense_MutationNAS426*0.56
COADchr897719175Missense_Mutationrs368307370V503I0.13
COADchr897719178Frame_Shift_DelNAN505Ifs*180.48
COADchr897713722Frame_Shift_DelNAK447Rfs*190.29
COADchr897661081Missense_Mutationrs758753771R131W0.09
COADchr897689044Missense_MutationNAS251Y0.1
COADchr897719086Missense_MutationnovelL473R0.22
COADchr897723006Missense_MutationNAT550I0.14
COADchr8977246753'UTRnovel0.13
ESCAchr8977250273'UTRnovel0.11
ESCAchr8977248773'UTRnovel0.14
GBMchr897723015Missense_MutationNAN553S0.33
GBMchr897644612SilentnovelL36L0.24
GBMchr897644784Missense_Mutationrs754496543A93V0.57
GBMchr897691177Missense_MutationnovelF346C0.04
GBMchr897719110Missense_Mutationrs143317071R481H0.46
HNSCchr897723010Missense_MutationnovelK551N0.24
HNSCchr897691096Missense_MutationnovelP319L0.18
HNSCchr897644799Missense_MutationnovelA98V0.54
HNSCchr897719189Missense_MutationnovelQ507H0.32
HNSCchr897719110Missense_Mutationrs143317071R481H0.24
KIRCchr897713761Missense_MutationnovelT458P0.57
KIRCchr897713762Missense_MutationnovelT458I0.57
KIRCchr897690979Missense_MutationNAT280S0.19
KIRCchr897719153SilentnovelT495T0.37
KIRCchr897691172SilentNAS344S0.22
KIRPchr897713745Frame_Shift_InsnovelG453Mfs*140.15
KIRPchr897713746Frame_Shift_InsnovelE454Yfs*140.15
LGGchr897722919Missense_MutationnovelS521Y0.1
LUADchr897722931Missense_MutationnovelS525L0.25
LUADchr897661091Frame_Shift_DelnovelE134Vfs*120.32
LUADchr897706640Missense_MutationnovelA388S0.17
LUSCchr897661161Missense_MutationnovelK157N0.19
LUSCchr897644524Nonsense_MutationnovelW6*0.13
LUSCchr8976444995'UTRnovel0.3
LUSCchr897722898Missense_MutationnovelP514L0.28
LUSCchr897691002Missense_MutationnovelE288K0.21
LUSCchr897644552Missense_MutationnovelE16K0.15
LUSCchr897699759Missense_Mutationrs756601591T352A0.34
LUSCchr897719055Missense_MutationNAE463K0.12
LUSCchr8977248163'UTRnovel0.25
LUSCchr897691146Missense_MutationNAW336R0.08
OVchr897713721Missense_MutationnovelK444N0.09
PRADchr897644872SilentNAL122L0.31
PRADchr897699800Missense_MutationnovelQ365H0.38
PRADchr897724620Missense_MutationnovelE567Q0.13
READchr897719110Missense_Mutationrs143317071R481H0.3
READchr897713722Frame_Shift_DelNAK447Rfs*190.33
READchr897706715Missense_MutationnovelL413I0.39
SKCMchr897719134Missense_Mutationrs779250302S489F0.42
SKCMchr897644802Missense_MutationNAA99V0.36
SKCMchr897644803SilentnovelA99A0.36
SKCMchr897691106Nonsense_MutationNAW322*0.43
SKCMchr897691057Missense_MutationNAS306F0.16
SKCMchr897691058Silentrs142598802S306S0.11
SKCMchr897719048Splice_SitenovelX461_splice0.26
SKCMchr897722960Nonsense_MutationNAQ535*0.75
SKCMchr897724626Missense_MutationnovelP569S0.37
STADchr8977246733'UTRnovel0.32
STADchr897691131Missense_MutationNAT331A0.29
STADchr897691010Frame_Shift_DelnovelV291Kfs*100.27
STADchr897699783Missense_MutationnovelT360P0.21
STADchr8977246733'UTRnovel0.26
STADchr897687465Missense_MutationNAR202Q0.09
STADchr897644784Missense_Mutationrs754496543A93V0.47
STADchr897687479Missense_MutationNAR207C0.23
THCAchr897713745Frame_Shift_InsnovelG453Mfs*140.12
THCAchr897713746Frame_Shift_InsnovelE454Yfs*30.12
THYMchr8977249703'UTRnovel0.05
UCECchr8977259293'UTRnovel0.5
UCECchr897722952Missense_MutationnovelS532I0.33
UCECchr897722980Missense_MutationNAQ541H0.56
UCECchr8977248123'UTRnovel0.29
UCECchr8977262443'UTRnovel0.41
UCECchr897689044Missense_MutationNAS251Y0.05
UCECchr897719153SilentnovelT495T0.47
UCECchr897691095Missense_MutationnovelP319S0.36
UCECchr8977262683'UTRnovel0.34
UCECchr8977263993'UTRnovel0.42
UCECchr897691054Missense_MutationNAN305S0.24
UCECchr897713664Splice_RegionnovelV425V0.08
UCECchr8977258493'UTRnovel0.48
UCECchr897699801Missense_MutationNAW366R0.22
UCECchr897722915Missense_MutationNAP520S0.19
UCECchr897719057Missense_MutationnovelE463D0.16
UCECchr897691127SilentnovelA329A0.18
UCECchr897706751Splice_SitenovelX424_splice0.22
UCECchr897687490SilentnovelV210V0.28
UCECchr8977256573'UTRnovel0.31
UCECchr8977259573'UTRnovel0.38
UCECchr897722894Frame_Shift_DelnovelP513Hfs*100.32
UCECchr8977247193'UTRnovel0.34
UCECchr8977246723'UTRrs1474696110.37
UCECchr8977256853'UTRnovel0.43
UCECchr897713721Frame_Shift_InsnovelK448Efs*70.42
UCECchr897689044Missense_MutationNAS251Y0.19
UCECchr897719058Nonsense_MutationnovelE464*0.13
UCECchr8977257163'UTRnovel0.17
UCECchr8977259793'UTRnovel0.15
UCECchr8977263973'UTRnovel0.19
UCECchr897706709Missense_MutationnovelS411P0.23
UCECchr8977261823'UTRnovel0.07
UCECchr8977258463'UTRnovel0.26
UCECchr897644520Missense_MutationnovelS5N0.3
UCECchr8977246713'UTRnovel0.39
UCECchr8977256943'UTRnovel0.35
UCECchr897699775Missense_MutationNAS357Y0.33
UCECchr897706733Missense_MutationnovelI419L0.19
UCECchr897706704Missense_MutationnovelR409I0.05
UCECchr8977248373'UTRnovel0.33
UCECchr8977254033'UTRnovel0.43
UCECchr8977255973'UTRnovel0.2
UCECchr897686724SilentnovelS180S0.33
UCECchr897661077Missense_MutationnovelN129K0.37
UCECchr897687519Missense_MutationnovelT220I0.29
UCECchr897706704Missense_MutationnovelR409I0.14
UCECchr897689092Missense_MutationNAS267Y0.45
UCECchr8977247723'UTRnovel0.46
UCECchr8977247293'UTRnovel0.31
UCECchr897719128Missense_MutationNAA487D0.17
UCECchr897713722Frame_Shift_DelNAK447Rfs*190.32
UCECchr8977256393'UTRnovel0.38
UCECchr897713705Missense_MutationnovelT439I0.46
UCECchr8977251283'UTRnovel0.42
UCECchr8977249933'UTRnovel0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCAMP0.10230.15559
PRADAMP0.26423.7005e-05
SARCAMP0.28020.18425
TGCTAMP0.660.13696
THCADEL0.0080.038162

Survival Analysis
CancerP-value Q-value
THYM0.0049

Kaplan-Meier Survival Analysis

KIRC0.019

Kaplan-Meier Survival Analysis

STAD0.012

Kaplan-Meier Survival Analysis

MESO0.048

Kaplan-Meier Survival Analysis

HNSC0.023

Kaplan-Meier Survival Analysis

SKCM0.0041

Kaplan-Meier Survival Analysis

LUSC0.0045

Kaplan-Meier Survival Analysis

BRCA0.00041

Kaplan-Meier Survival Analysis

KIRP0.00016

Kaplan-Meier Survival Analysis

COAD0.012

Kaplan-Meier Survival Analysis

PAAD0.001

Kaplan-Meier Survival Analysis

CESC0.019

Kaplan-Meier Survival Analysis

KICH0.0043

Kaplan-Meier Survival Analysis

LIHC0.04

Kaplan-Meier Survival Analysis

LGG0.0073

Kaplan-Meier Survival Analysis

LUAD0.014

Kaplan-Meier Survival Analysis

UVM0.0026

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000147649 (Gene tree)
Gene ID
92140
Gene Symbol
MTDH
Alias
LYRIC|3D3|AEG-1
Full Name
metadherin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
86,114 bases
Position
chr8:97,644,147-97,730,260
Accession
29608
RBP type
non-canonical RBP
Summary
(Metadherin) is a Protein Coding gene. Diseases associated with MTDH include Gallbladder Adenocarcinoma and External Ear Disease. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is MAMSTR.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22199357Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.J Biol Chem2012 Feb 10Meng Xdoi: 10.1074/jbc.C111.291518
29438049Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs.RNA2018 MayHsu JCdoi: 10.1261/rna.063313.117
25787750A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway.Tumour Biol2015 AugLi Cdoi: 10.1007/s13277-015-3314-5
23889990Drug resistance mediated by AEG-1/MTDH/LYRIC.Adv Cancer Res2013Meng Xdoi: 10.1016/B978-0-12-401676-7.00005-X.
28634830The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.Arch Dermatol Res2017 SepHessam Sdoi: 10.1007/s00403-017-1752-1
30588098Clinical significance and effect of MTDH/AEG-1 in bladder urothelial cancer: a study based on immunohistochemistry, RNA-seq, and in vitro verification.Cancer Manag Res2018 Dec 14Zhang Ydoi: 10.2147/CMAR.S176887
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000519934MTDH-2032184XM_005251099ENSP00000428168526 (aa)XP_016869457E5RJU9
ENST00000522104MTDH-205486--- (aa)--
ENST00000519293MTDH-202629-ENSP0000042928960 (aa)-H0YBE0
ENST00000521933MTDH-204565-ENSP00000429642188 (aa)-H0YBJ8
ENST00000336273MTDH-2016177XM_011517367ENSP00000338235582 (aa)XP_011515670Q86UE4
ENST00000522313MTDH-206672-ENSP00000428703224 (aa)-H0YB56
Gene Model
Click here to download ENSG00000147649's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000147649Platelet Function Tests2.4367200E-005-
ENSG00000147649Platelet Function Tests3.6370200E-005-
ENSG00000147649Platelet Function Tests2.6556900E-005-
ENSG00000147649Platelet Function Tests2.4367200E-005-
ENSG00000147649Platelet Function Tests3.6370200E-005-
ENSG00000147649Platelet Function Tests2.6556900E-005-
ENSG00000147649Platelet Function Tests1.3747600E-005-
ENSG00000147649Platelet Function Tests1.4674900E-005-
ENSG00000147649Platelet Function Tests1.5596500E-005-
ENSG00000147649Platelet Function Tests1.7476900E-005-
ENSG00000147649Platelet Function Tests5.7300000E-006-
ENSG00000147649Platelet Function Tests4.0700000E-006-
ENSG00000147649Platelet Function Tests4.6000000E-006-
ENSG00000147649Platelet Function Tests4.9200000E-006-
ENSG00000147649Platelet Function Tests4.4600000E-006-
ENSG00000147649Platelet Function Tests4.8400000E-006-
ENSG00000147649Platelet Function Tests6.4200000E-006-
ENSG00000147649Platelet Function Tests6.0200000E-006-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000147649rs149211171897708529?Mean corpuscular hemoglobin29403010[0.017-0.036] unit increase novel0.02684EFO_0004527
ENSG00000147649rs2468024897652425ARed cell distribution width28957414[0.057-0.088] unit decrease0.0721306EFO_0005192
ENSG00000147649rs2449511897723714?Red cell distribution width30595370EFO_0005192
ENSG00000147649rs2468024897652425?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147649's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000147649MTDH10091.065ENSMUSG00000022255Mtdh10090.722Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II15927426.IDAProcess
GO:0001085RNA polymerase II transcription factor binding21873635.IBAFunction
GO:0001085RNA polymerase II transcription factor binding18316612.IPIFunction
GO:0001650fibrillar center-IDAComponent
GO:0003713transcription coactivator activity18316612.IMPFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003725double-stranded RNA binding21266579.IDAFunction
GO:0005515protein binding18316612.18440304.19433866.19648967.24981741.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus16452207.IDAComponent
GO:0005737cytoplasm19648967.IDAComponent
GO:0005783endoplasmic reticulum14980505.15927426.IDAComponent
GO:0005789endoplasmic reticulum membrane21873635.IBAComponent
GO:0005789endoplasmic reticulum membrane-ISSComponent
GO:0005923bicellular tight junction-ISSComponent
GO:0010508positive regulation of autophagy21127263.IDAProcess
GO:0016021integral component of membrane-IEAComponent
GO:0016324apical plasma membrane-ISSComponent
GO:0016604nuclear body19648967.IDAComponent
GO:0031663lipopolysaccharide-mediated signaling pathway19740331.IMPProcess
GO:0031965nuclear membrane-IEAComponent
GO:0043066negative regulation of apoptotic process17704808.IDAProcess
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling16452207.18316612.IDAProcess
GO:0045766positive regulation of angiogenesis19940250.IDAProcess
GO:0046581intercellular canaliculus-ISSComponent
GO:0048471perinuclear region of cytoplasm14980505.15927426.IDAComponent
GO:0051059NF-kappaB binding21873635.IBAFunction
GO:0051059NF-kappaB binding16452207.IPIFunction
GO:0051092positive regulation of NF-kappaB transcription factor activity16452207.18316612.IDAProcess
GO:0051897positive regulation of protein kinase B signaling17704808.IDAProcess
GO:0070830bicellular tight junction assembly-IEAProcess
GO:1903508positive regulation of nucleic acid-templated transcription-IEAProcess
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