EuRBPDB

Ensembl ID

ENSG00000147206 (Gene tree)

Gene ID

56000

Gene Symbol

NXF3

Alias

N

Full Name

nuclear RNA export factor 3

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Minus strand

Length

17,316 bases

Position

chrX:103,075,810-103,093,125

Accession

8073

Summary

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]