EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28104536Exome-Wide Association Study Identifies Low-Frequency Coding Variants in 2p23.2 and 7p11.2 Associated with Survival of Non-Small Cell Lung Cancer Patients.J Thorac Oncol2017 AprZhu Mdoi: 10.1016/j.jtho.2016.12.025

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr756058104Splice_SitenovelX242_splice0.11
ACCchr756060379Missense_MutationnovelR392S0.25
BLCAchr756058085Missense_MutationnovelS236L0.21
BLCAchr756058647Missense_MutationNAL305V0.22
BLCAchr756060570Intronnovel0.24
BLCAchr756055630Missense_MutationnovelH115Y0.5
BLCAchr756060570Intronnovel0.61
BLCAchr756055658Missense_Mutationrs758284765E124V0.13
BRCAchr7560630923'UTRnovel0.35
BRCAchr756062757Splice_SitenovelX508_splice0.21
BRCAchr756060917Missense_Mutationrs770231271D442N0.29
BRCAchr756060318Missense_MutationNAV372A0.28
CESCchr756056359Missense_MutationnovelD187N0.23
CESCchr756054455SilentNAV96V0.13
CESCchr756054499Missense_MutationNAS111C0.13
CESCchr756058503Missense_MutationnovelF289L0.12
CESCchr756058505In_Frame_InsnovelV290_V291insLRFNS0.13
CESCchr756058479SilentnovelV281V0.2
CESCchr756055448IntronNA0.19
COADchr756055751Missense_MutationNAS155Y0.45
COADchr756058028Missense_MutationNAR217Q0.06
COADchr756058661SilentNAG309G0.17
COADchr756060903Missense_MutationNAV437A0.3
COADchr756058450Frame_Shift_DelNAI274*0.21
COADchr756058378Frame_Shift_DelnovelY250Tfs*110.09
COADchr756060861Missense_MutationNAI423N0.29
COADchr756058378Frame_Shift_DelnovelY250Tfs*110.45
COADchr756058658Missense_MutationnovelE308D0.05
COADchr756060896Missense_MutationnovelL435I0.05
COADchr756058408Missense_MutationNAK258Q0.14
COADchr756060833Missense_MutationnovelV414M0.25
DLBCchr756061761Missense_MutationnovelN454K0.24
ESCAchr7560517825'UTRrs5353812740.27
ESCAchr756058039Missense_MutationnovelM221L0.54
GBMchr756054496Missense_MutationnovelI110S0.1
HNSCchr756061777Nonsense_MutationnovelQ460*0.17
HNSCchr756060272Missense_MutationnovelE357K0.12
HNSCchr756056359Missense_MutationnovelD187H0.11
HNSCchr756062752Missense_MutationnovelS507C0.24
HNSCchr756052446SilentnovelI54I0.37
HNSCchr756060891Missense_MutationnovelA433V0.34
KIRPchr756060853SilentnovelE420E0.61
KIRPchr7560631343'UTRnovel0.34
KIRPchr756062719Missense_MutationnovelD496V0.41
LGGchr756060593Intronnovel0.06
LGGchr756059611Missense_MutationnovelH346Y0.29
LIHCchr756058093Missense_MutationnovelY239H0.4
LIHCchr756060273Missense_MutationnovelE357G0.42
LIHCchr7560518125'UTRrs7616652140.3
LIHCchr7560518375'UTRnovel0.22
LIHCchr7560518385'UTRnovel0.22
LUADchr756058698Nonsense_MutationnovelE322*0.25
LUADchr756058510Missense_MutationNAI292V0.27
LUADchr756054461Missense_Mutationrs368822326I98M0.08
LUADchr756061822Missense_MutationnovelQ475E0.25
LUADchr756059608Nonsense_MutationnovelG345*0.2
LUADchr756056374Missense_MutationNAE192Q0.04
LUADchr756058695Missense_MutationnovelM321V0.24
LUADchr756058061Missense_MutationNAA228V0.45
LUADchr756058659Missense_MutationnovelG309C0.51
LUSCchr756060827Missense_MutationnovelG412C0.42
LUSCchr756054414Missense_MutationNAA83T0.23
LUSCchr756058450Frame_Shift_DelNAI274*0.16
LUSCchr756054438Missense_MutationnovelG91C0.18
LUSCchr756060495Intronnovel0.11
LUSCchr756055678Missense_MutationnovelL131V0.64
LUSCchr756058001Missense_MutationnovelR208T0.5
LUSCchr756059556SilentNAA327A0.35
LUSCchr756060383Missense_MutationnovelG394C0.46
LUSCchr756058049Missense_MutationNAR224K0.29
LUSCchr756055690Nonsense_MutationnovelE135*0.16
PAADchr756058084Missense_MutationnovelS236P0.16
READchr756058450Frame_Shift_DelNAI274*0.22
READchr756058462Nonsense_MutationNAE276*0.38
READchr7560631833'UTRnovel0.33
SKCMchr756063052Silentrs374991164I521I0.37
SKCMchr756060920Frame_Shift_InsnovelL444Ffs*160.27
SKCMchr756054403Missense_MutationnovelK79M0.33
SKCMchr756054404SilentnovelK79K0.32
SKCMchr756055657Missense_MutationnovelE124K0.08
SKCMchr756055670Frame_Shift_DelnovelK129Rfs*110.09
SKCMchr756060537Intronnovel0.84
SKCMchr756060818Missense_MutationNAP409S0.26
SKCMchr756054499Missense_Mutationrs758352451S111F0.29
STADchr756058421Missense_MutationNAA262V0.09
STADchr756060527Intronnovel0.11
STADchr756058397Frame_Shift_InsnovelL259Nfs*30.19
STADchr756058377Frame_Shift_InsNAY250Lfs*140.35
STADchr756060474Intronnovel0.37
STADchr756061783Missense_MutationnovelT462S0.12
STADchr756060884Missense_MutationNAG431S0.26
STADchr7560631873'UTRnovel0.35
STADchr756058377Frame_Shift_InsNAY250Lfs*140.17
STADchr756054416SilentnovelA83A0.18
STADchr756055758SilentNAR157R0.17
STADchr756060916SilentNAA441A0.12
STADchr756054414Missense_MutationNAA83T0.21
TGCTchr756051961Missense_MutationnovelL38Q0.26
UCECchr756061758Silentrs7799515Q453Q0.18
UCECchr756063076SilentNAL529L0.11
UCECchr756061809Missense_MutationnovelH470Q0.23
UCECchr756055751Missense_MutationnovelS155F0.17
UCECchr756058080Silentrs567948145N234N0.34
UCECchr756058674Missense_MutationnovelR314C0.52
UCECchr756058044Missense_MutationnovelK222N0.08
UCECchr756054483Missense_MutationnovelA106T0.09
UCECchr756055766Missense_MutationnovelV160A0.03
UCECchr756060312Missense_Mutationrs764432664R370H0.24
UCECchr7560631123'UTRnovel0.21
UCECchr756058029SilentNAR217R0.48
UCECchr7560518275'UTRnovel0.21
UCECchr7560631503'UTRnovel0.42
UCECchr756058450Frame_Shift_DelNAI274*0.43
UCECchr756060312Missense_Mutationrs764432664R370H0.31
UCECchr756058447Missense_MutationnovelV271I0.46
UCECchr756054485Silentrs148293442A106A0.16
UCECchr756060926Missense_Mutationrs767086827L445F0.23
UCECchr756058377Frame_Shift_InsNAY250Lfs*140.34
UCECchr756058675Missense_MutationNAR314H0.37
UCECchr756062717Missense_MutationNAW495C0.18
UCECchr756055726Missense_MutationnovelT147A0.2
UCECchr756051934Missense_MutationnovelG29D0.34
UCECchr756051850Translation_Start_SitenovelM1?0.47
UCECchr756058081Missense_MutationNAV235M0.2
UCECchr756060275Missense_MutationNAE358Q0.26
UCECchr756058450Frame_Shift_DelNAI274*0.45
UCECchr756058434Missense_MutationnovelF266L0.41
UCECchr756055723Missense_MutationnovelE146K0.26
UCECchr756058687Missense_MutationnovelR318M0.15
UCECchr756058450Frame_Shift_DelNAI274*0.2
UCECchr756058675Missense_MutationNAR314H0.27
UCECchr7560631193'UTRnovel0.18

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
THCADEL00.27619

Survival Analysis
CancerP-value Q-value
SARC0.016

Kaplan-Meier Survival Analysis

MESO0.0029

Kaplan-Meier Survival Analysis

ACC0.00028

Kaplan-Meier Survival Analysis

HNSC0.0019

Kaplan-Meier Survival Analysis

LUSC0.021

Kaplan-Meier Survival Analysis

BRCA0.0059

Kaplan-Meier Survival Analysis

KIRP0.0077

Kaplan-Meier Survival Analysis

PAAD0.05

Kaplan-Meier Survival Analysis

BLCA0.033

Kaplan-Meier Survival Analysis

CESC0.0011

Kaplan-Meier Survival Analysis

READ0.042

Kaplan-Meier Survival Analysis

KICH0.0086

Kaplan-Meier Survival Analysis

LIHC0.00012

Kaplan-Meier Survival Analysis

DLBC0.037

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

OV0.047

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000146731 (Gene tree)
Gene ID
908
Gene Symbol
CCT6A
Alias
TTCP20|TCPZ|Cctz|HTR3|TCP20|CCT6
Full Name
chaperonin containing TCP1 subunit 6A
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
12,360 bases
Position
chr7:56,051,630-56,063,989
Accession
1620
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000492618CCT6A-207692--- (aa)--
ENST00000462133CCT6A-203665--- (aa)--
ENST00000335503CCT6A-2022529-ENSP00000352019486 (aa)-P40227
ENST00000482776CCT6A-206765--- (aa)--
ENST00000275603CCT6A-2012719-ENSP00000275603531 (aa)-P40227
ENST00000493855CCT6A-208261--- (aa)--
ENST00000466572CCT6A-205686--- (aa)--
ENST00000466479CCT6A-204745--- (aa)--
ENST00000494736CCT6A-209411--- (aa)--
Gene Model
Click here to download ENSG00000146731's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000146731rs6593297756054365ASystolic blood pressure30224653[0.1-0.21] mmHg increase0.1581EFO_0006335
ENSG00000146731rs7793921756053188GPlasma free amino acid levels (adjusted for twenty other PFAAs)30659259[0.22-0.3] unit decrease0.26EFO_0009774|EFO_0005134
ENSG00000146731rs7793921756053188GPlasma free amino acid levels30659259[0.28-0.4] unit decrease0.34EFO_0009774|EFO_0005134
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146731's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding14532270.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005737cytoplasm8034610.TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005832chaperonin-containing T-complex21873635.IBAComponent
GO:0005832chaperonin-containing T-complex23011926.IDAComponent
GO:0005832chaperonin-containing T-complex25467444.TASComponent
GO:0005874microtubule21525035.IDAComponent
GO:0006457protein folding-TASProcess
GO:0032212positive regulation of telomere maintenance via telomerase25467444.IMPProcess
GO:0050821protein stabilization25467444.IMPProcess
GO:0051082unfolded protein binding-IEAFunction
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0071987WD40-repeat domain binding25467444.IPIFunction
GO:1904851positive regulation of establishment of protein localization to telomere25467444.IMPProcess
GO:1904871positive regulation of protein localization to Cajal body25467444.HMPProcess
GO:1904874positive regulation of telomerase RNA localization to Cajal body25467444.HMPProcess
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