EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr351387868SilentnovelE118E0.36
BLCAchr3513891133'UTRnovel0.35
BLCAchr351388936SilentNAL132L0.5
BLCAchr351386224SilentnovelL37L0.55
CESCchr351386288Missense_MutationNAE59Q0.5
COADchr351386336Splice_Siters113724505X74_splice0.11
COADchr351388980Frame_Shift_DelNAE149Rfs*160.3
COADchr351387870Missense_MutationNAL119P0.33
COADchr3513891203'UTRnovel0.53
GBMchr351387875Missense_MutationNAY121H0.29
LIHCchr351389072Missense_MutationNAA178T0.41
LUADchr351387785Missense_MutationNAE91K0.34
LUSCchr351387825Missense_MutationnovelK104M0.16
LUSCchr351387779Missense_MutationnovelI89V0.57
LUSCchr351389082Missense_MutationnovelD181A0.31
MESOchr3513853305'UTRnovel0.08
OVchr351386252Nonsense_MutationnovelR47*0.27
SKCMchr351388946Nonsense_MutationNAR136*0.29
UCECchr351389051Missense_MutationnovelY171H0.21
UCECchr3513891203'UTRnovel0.29
UCECchr351387748Silentrs781942956I78I0.47
UCECchr3513891203'UTRnovel0.37
UCECchr351387829SilentnovelI105I0.31
UCECchr351389083Missense_MutationnovelD181E0.38
UCECchr3513891203'UTRnovel0.2
UCECchr3513891203'UTRnovel0.22
UCECchr351386333Splice_RegionnovelL74L0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.77780.016387
GBMDEL0.07970.056565
LGGDEL0.07990.00089193
LUADDEL0.33330.0021265
PAADDEL0.19020.030662
SARCDEL0.22180.0034746
SKCMDEL0.16350.13887
TGCTAMP0.140.23596
THYMDEL0.08130.037527

Survival Analysis
CancerP-value Q-value
KIRC0.00025

Kaplan-Meier Survival Analysis

SARC0.0033

Kaplan-Meier Survival Analysis

ACC0.015

Kaplan-Meier Survival Analysis

HNSC0.002

Kaplan-Meier Survival Analysis

SKCM0.02

Kaplan-Meier Survival Analysis

BRCA0.042

Kaplan-Meier Survival Analysis

ESCA0.031

Kaplan-Meier Survival Analysis

COAD0.0086

Kaplan-Meier Survival Analysis

UCEC0.033

Kaplan-Meier Survival Analysis

GBM0.032

Kaplan-Meier Survival Analysis

LIHC0.0043

Kaplan-Meier Survival Analysis

LGG0.00025

Kaplan-Meier Survival Analysis

UVM0.017

Kaplan-Meier Survival Analysis

OV0.00042

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000145050 (Gene tree)
Gene ID
7873
Gene Symbol
MANF
Alias
ARP|ARMET
Full Name
mesencephalic astrocyte derived neurotrophic factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
4,351 bases
Position
chr3:51,385,047-51,389,397
Accession
15461
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000470900MANF-2021509--- (aa)--
ENST00000649711MANF-205992--- (aa)--
ENST00000482262MANF-203436--- (aa)--
ENST00000446668MANF-201846-ENSP0000040528071 (aa)-H7C2D6
ENST00000528157MANF-2041153-ENSP00000432799185 (aa)-A8K878
Gene Model
Click here to download ENSG00000145050's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145050's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000145050MANF9797.765ENSMUSG00000032575Manf10097.765Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002576platelet degranulation-TASProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space21873635.IBAComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005783endoplasmic reticulum21873635.IBAComponent
GO:0005788endoplasmic reticulum lumen29497057.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006986response to unfolded protein-IEAProcess
GO:0008083growth factor activity-IEAFunction
GO:0010469regulation of signaling receptor activity-IEAProcess
GO:0031175neuron projection development21873635.IBAProcess
GO:0033018sarcoplasmic reticulum lumen-IEAComponent
GO:0071542dopaminergic neuron differentiation21873635.IBAProcess
GO:0120146sulfatide binding29497057.IPIFunction
GO:1905897regulation of response to endoplasmic reticulum stress29497057.IMPProcess
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