EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	51387868	Silent	novel	E118E	0.36
BLCA	chr3	51389113	3'UTR	novel		0.35
BLCA	chr3	51388936	Silent	NA	L132L	0.5
BLCA	chr3	51386224	Silent	novel	L37L	0.55
CESC	chr3	51386288	Missense_Mutation	NA	E59Q	0.5
COAD	chr3	51386336	Splice_Site	rs113724505	X74_splice	0.11
COAD	chr3	51388980	Frame_Shift_Del	NA	*E149Rfs16**	0.3
COAD	chr3	51387870	Missense_Mutation	NA	L119P	0.33
COAD	chr3	51389120	3'UTR	novel		0.53
GBM	chr3	51387875	Missense_Mutation	NA	Y121H	0.29
LIHC	chr3	51389072	Missense_Mutation	NA	A178T	0.41
LUAD	chr3	51387785	Missense_Mutation	NA	E91K	0.34
LUSC	chr3	51387825	Missense_Mutation	novel	K104M	0.16
LUSC	chr3	51387779	Missense_Mutation	novel	I89V	0.57
LUSC	chr3	51389082	Missense_Mutation	novel	D181A	0.31
MESO	chr3	51385330	5'UTR	novel		0.08
OV	chr3	51386252	Nonsense_Mutation	novel	R47*	0.27
SKCM	chr3	51388946	Nonsense_Mutation	NA	R136*	0.29
UCEC	chr3	51389051	Missense_Mutation	novel	Y171H	0.21
UCEC	chr3	51389120	3'UTR	novel		0.29
UCEC	chr3	51387748	Silent	rs781942956	I78I	0.47
UCEC	chr3	51389120	3'UTR	novel		0.37
UCEC	chr3	51387829	Silent	novel	I105I	0.31
UCEC	chr3	51389083	Missense_Mutation	novel	D181E	0.38
UCEC	chr3	51389120	3'UTR	novel		0.2
UCEC	chr3	51389120	3'UTR	novel		0.22
UCEC	chr3	51386333	Splice_Region	novel	L74L	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.7778	0.016387
GBM	DEL	0.0797	0.056565
LGG	DEL	0.0799	0.00089193
LUAD	DEL	0.3333	0.0021265
PAAD	DEL	0.1902	0.030662
SARC	DEL	0.2218	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	AMP	0.14	0.23596
THYM	DEL	0.0813	0.037527

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00025	Kaplan-Meier Survival Analysis
SARC	0.0033	Kaplan-Meier Survival Analysis
ACC	0.015	Kaplan-Meier Survival Analysis
HNSC	0.002	Kaplan-Meier Survival Analysis
SKCM	0.02	Kaplan-Meier Survival Analysis
BRCA	0.042	Kaplan-Meier Survival Analysis
ESCA	0.031	Kaplan-Meier Survival Analysis
COAD	0.0086	Kaplan-Meier Survival Analysis
UCEC	0.033	Kaplan-Meier Survival Analysis
GBM	0.032	Kaplan-Meier Survival Analysis
LIHC	0.0043	Kaplan-Meier Survival Analysis
LGG	0.00025	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis
OV	0.00042	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000145050 (Gene tree)
Gene ID: 7873
Gene Symbol: MANF
Alias: ARP|ARMET
Full Name: mesencephalic astrocyte derived neurotrophic factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 4,351 bases
Position: chr3:51,385,047-51,389,397
Accession: 15461
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000470900	MANF-202	1509	-	-	- (aa)	-	-
ENST00000649711	MANF-205	992	-	-	- (aa)	-	-
ENST00000482262	MANF-203	436	-	-	- (aa)	-	-
ENST00000446668	MANF-201	846	-	ENSP00000405280	71 (aa)	-	H7C2D6
ENST00000528157	MANF-204	1153	-	ENSP00000432799	185 (aa)	-	A8K878

Gene Model

Click here to download ENSG00000145050's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145050's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000145050	MANF	97	97.765	ENSMUSG00000032575	Manf	100	97.765	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	21873635.	IBA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005788	endoplasmic reticulum lumen	29497057.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006986	response to unfolded protein	-	IEA	Process
GO:0008083	growth factor activity	-	IEA	Function
GO:0010469	regulation of signaling receptor activity	-	IEA	Process
GO:0031175	neuron projection development	21873635.	IBA	Process
GO:0033018	sarcoplasmic reticulum lumen	-	IEA	Component
GO:0071542	dopaminergic neuron differentiation	21873635.	IBA	Process
GO:0120146	sulfatide binding	29497057.	IPI	Function
GO:1905897	regulation of response to endoplasmic reticulum stress	29497057.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.