EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17963294	Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer.	World J Gastroenterol	2007 Nov 21	Wang JF	-
20651337	Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.	Anticancer Res	2010 Jun	Shu ST	-
21150880	Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.	Eur J Hum Genet	2011 Mar	van Roon EH	doi: 10.1038/ejhg.2010.187
18646686	[Methylation of PTPRG gene and its regulation in gastric cancer].	Zhonghua Zhong Liu Za Zhi	2008 Feb	Wang JF	-
27602768	MiR-19b suppresses PTPRG to promote breast tumorigenesis.	Oncotarget	2016 Sep 27	Liu M	doi: 10.18632/oncotarget.11799.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	62263025	Intron	novel		0.73
ACC	chr3	62191517	Missense_Mutation	rs751693280	T361M	0.25
BLCA	chr3	62195159	Missense_Mutation	novel	M439K	0.13
BLCA	chr3	62273077	Missense_Mutation	novel	T1105N	0.21
BLCA	chr3	62157199	Missense_Mutation	novel	R272T	0.07
BLCA	chr3	61989652	Missense_Mutation	rs182010071	T73M	0.21
BLCA	chr3	62203694	Silent	novel	T633T	0.21
BLCA	chr3	61562343	Missense_Mutation	novel	S19F	0.06
BLCA	chr3	62124241	Intron	novel		0.55
BLCA	chr3	62132610	Silent	rs533835628	P208P	0.11
BLCA	chr3	62271470	Missense_Mutation	rs751271092	E1033K	0.36
BLCA	chr3	62269097	Silent	rs143908630	T979T	0.53
BLCA	chr3	62262897	Splice_Region	novel		0.11
BLCA	chr3	62203181	Silent	rs757781094	A462A	0.16
BLCA	chr3	62168061	Missense_Mutation	rs762084994	R311C	0.15
BLCA	chr3	62167974	Missense_Mutation	novel	E282Q	0.35
BLCA	chr3	62003368	Silent	rs189356599	D130D	0.25
BLCA	chr3	62275920	Silent	NA	Q1171Q	0.43
BLCA	chr3	62003411	Missense_Mutation	rs749642322	A145S	0.52
BLCA	chr3	61562326	Silent	novel	F13F	0.62
BLCA	chr3	62203923	Missense_Mutation	NA	D710H	0.28
BLCA	chr3	61989726	Missense_Mutation	novel	E98Q	0.13
BRCA	chr3	62124311	Intron	novel		0.41
BRCA	chr3	62203267	Missense_Mutation	novel	S491F	0.09
BRCA	chr3	61989687	Missense_Mutation	NA	P85A	0.19
BRCA	chr3	62124402	Intron	novel		0.34
BRCA	chr3	62078165	Missense_Mutation	novel	M174I	0.32
BRCA	chr3	62078166	Nonsense_Mutation	novel	Q175*	0.32
BRCA	chr3	62218936	Missense_Mutation	NA	L747F	0.13
BRCA	chr3	62271510	Missense_Mutation	rs768919412	S1046L	0.11
BRCA	chr3	62293511	3'UTR	novel		0.41
BRCA	chr3	62273743	Missense_Mutation	NA	G1122R	0.14
BRCA	chr3	62282757	Missense_Mutation	NA	Q1315E	0.34
BRCA	chr3	62255217	Splice_Site	NA	X853_splice	0.21
BRCA	chr3	61562334	Missense_Mutation	novel	I16S	0.13
BRCA	chr3	62231224	Splice_Site	NA	X763_splice	0.17
BRCA	chr3	62269100	Silent	NA	L980L	0.18
BRCA	chr3	62124244	Intron	novel		0.07
BRCA	chr3	62003369	Missense_Mutation	novel	D131H	0.19
BRCA	chr3	61562363	Missense_Mutation	novel	C26G	0.91
BRCA	chr3	62003443	Frame_Shift_Ins	NA	*N156Kfs7**	0.58
BRCA	chr3	62132649	Missense_Mutation	novel	L221F	0.17
BRCA	chr3	62203610	Missense_Mutation	novel	K605N	0.14
CESC	chr3	62168114	Silent	rs747299296	H328H	0.18
CESC	chr3	62078235	Missense_Mutation	NA	G198R	0.26
CESC	chr3	62168023	Missense_Mutation	NA	S298L	0.44
CESC	chr3	61989653	Silent	rs187568366	T73T	0.46
CESC	chr3	62203780	Missense_Mutation	novel	A662V	0.25
CESC	chr3	62124588	Intron	novel		0.33
CESC	chr3	62281679	Silent	NA	I1294I	0.8
CESC	chr3	62277551	Missense_Mutation	NA	G1213S	0.39
CESC	chr3	62191641	Silent	novel	S402S	0.25
CESC	chr3	62243896	Missense_Mutation	rs538902396	P822L	0.31
CESC	chr3	62267753	Nonsense_Mutation	NA	W936*	0.35
CHOL	chr3	62124602	Intron	novel		0.07
CHOL	chr3	62293612	3'UTR	novel		0.33
CHOL	chr3	62282748	Missense_Mutation	rs754335459	R1312W	0.17
COAD	chr3	62281605	Frame_Shift_Ins	novel	E1273*	0.29
COAD	chr3	62218942	Silent	rs376160752	F749F	0.34
COAD	chr3	62243806	Frame_Shift_Ins	NA	*C794Mfs20**	0.25
COAD	chr3	62293322	3'UTR	novel		0.23
COAD	chr3	62157118	Missense_Mutation	rs577302571	S245F	0.03
COAD	chr3	62203373	Missense_Mutation	NA	I526M	0.51
COAD	chr3	62231261	Missense_Mutation	novel	R775S	0.27
COAD	chr3	62277039	Silent	novel	S1209S	0.08
COAD	chr3	62124478	Intron	novel		0.29
COAD	chr3	62262961	Intron	novel		0.21
COAD	chr3	62267748	Missense_Mutation	novel	F935V	0.23
COAD	chr3	62277041	Missense_Mutation	rs375459395	Y1210C	0.4
COAD	chr3	62277045	Silent	novel	I1211I	0.33
COAD	chr3	62203925	Silent	NA	D710D	0.33
COAD	chr3	62269133	Silent	NA	V991V	0.28
COAD	chr3	62271461	Nonsense_Mutation	novel	G1030*	0.22
COAD	chr3	62272960	Missense_Mutation	NA	R1066T	0.15
COAD	chr3	62269135	Missense_Mutation	rs773599761	R992H	0.38
COAD	chr3	62273824	Nonsense_Mutation	novel	R1149*	0.22
COAD	chr3	62203200	Missense_Mutation	rs371587393	D469N	0.27
COAD	chr3	61989661	Missense_Mutation	NA	V76A	0.24
COAD	chr3	62124508	Intron	novel		0.13
COAD	chr3	62282754	Frame_Shift_Del	novel	*Q1315Sfs12**	0.24
COAD	chr3	62218879	Silent	NA	S728S	0.13
COAD	chr3	62267756	Missense_Mutation	novel	R937S	0.5
COAD	chr3	61989707	Missense_Mutation	NA	Q91H	0.36
COAD	chr3	62262722	Intron	novel		0.37
COAD	chr3	62262635	Intron	novel		0.21
COAD	chr3	62262741	Intron	novel		0.21
COAD	chr3	61748961	Missense_Mutation	rs753443145	D57N	0.28
COAD	chr3	61562328	Missense_Mutation	novel	L14P	0.1
COAD	chr3	62292536	Missense_Mutation	rs765112298	P1391S	0.12
COAD	chr3	62262891	Frame_Shift_Ins	novel	*A885Efs11**	0.09
COAD	chr3	61989691	Missense_Mutation	rs776898840	I86T	0.12
DLBC	chr3	62293191	Missense_Mutation	novel	L1408F	0.25
DLBC	chr3	62262735	Intron	novel		0.32
DLBC	chr3	62203634	Silent	rs150936656	H613H	0.14
ESCA	chr3	62203855	Missense_Mutation	NA	G687E	0.17
ESCA	chr3	62203238	Silent	rs544886184	T481T	0.32
ESCA	chr3	62292643	Intron	novel		0.6
ESCA	chr3	62243855	Silent	novel	P808P	0.41
ESCA	chr3	62293612	3'UTR	novel		0.43
ESCA	chr3	62124516	Intron	novel		0.77
ESCA	chr3	62124534	Intron	novel		0.25
GBM	chr3	62167976	Missense_Mutation	novel	E282D	0.08
GBM	chr3	62203949	Splice_Region	novel	P718P	0.14
GBM	chr3	61562357	Missense_Mutation	novel	V24L	0.76
GBM	chr3	61989714	Missense_Mutation	rs764140516	R94C	0.21
GBM	chr3	62203766	Silent	rs758300826	G657G	0.62
GBM	chr3	62203260	Frame_Shift_Ins	novel	*F489Cfs62**	0.09
GBM	chr3	62273790	Missense_Mutation	novel	N1137K	0.1
GBM	chr3	62273780	Missense_Mutation	novel	S1134I	0.07
GBM	chr3	62203180	Missense_Mutation	rs747382591	A462V	0.05
HNSC	chr3	62078168	Silent	novel	Q175Q	0.22
HNSC	chr3	62269064	Missense_Mutation	novel	E968D	0.15
HNSC	chr3	62275895	Missense_Mutation	novel	K1163R	0.1
HNSC	chr3	62218880	Missense_Mutation	rs770912567	R729C	0.61
HNSC	chr3	62275897	Missense_Mutation	NA	Y1164H	0.27
HNSC	chr3	62167997	Silent	novel	T289T	0.16
HNSC	chr3	62273027	Frame_Shift_Del	novel	*L1089Wfs4**	0.19
HNSC	chr3	62273028	Silent	novel	L1089L	0.19
HNSC	chr3	62269050	Missense_Mutation	novel	Y964H	0.23
HNSC	chr3	62269083	Missense_Mutation	novel	N975D	0.56
HNSC	chr3	62191510	Missense_Mutation	novel	N359D	0.2
HNSC	chr3	62262950	Intron	novel		0.63
HNSC	chr3	62203193	Silent	novel	S466S	0.19
HNSC	chr3	62203213	Missense_Mutation	novel	I473T	0.25
HNSC	chr3	62271420	Missense_Mutation	novel	R1016K	0.19
KIRC	chr3	62203659	Missense_Mutation	novel	E622K	0.53
KIRC	chr3	62124234	Intron	novel		0.29
KIRP	chr3	62293260	Missense_Mutation	novel	I1431F	0.47
KIRP	chr3	62124362	Intron	novel		0.73
KIRP	chr3	62124263	Intron	novel		0.51
KIRP	chr3	62203416	Missense_Mutation	NA	A541P	0.67
LAML	chr3	61742783	Intron	rs757593223		0.59
LGG	chr3	62282781	Missense_Mutation	novel	D1323H	0.1
LGG	chr3	62168001	Missense_Mutation	novel	E291K	0.33
LGG	chr3	62078166	Nonsense_Mutation	novel	Q175*	0.38
LGG	chr3	62269153	Missense_Mutation	novel	N998S	0.27
LGG	chr3	62293382	3'UTR	novel		0.13
LGG	chr3	62124208	Intron	novel		0.39
LGG	chr3	62262878	Nonsense_Mutation	NA	Y880*	0.09
LIHC	chr3	62262538	Intron	novel		0.33
LIHC	chr3	61989718	Missense_Mutation	NA	V95A	0.13
LIHC	chr3	61989718	Missense_Mutation	NA	V95A	0.49
LUAD	chr3	62124279	Intron	novel		0.2
LUAD	chr3	61989781	Nonsense_Mutation	novel	W116*	0.12
LUAD	chr3	61989782	Missense_Mutation	novel	W116C	0.12
LUAD	chr3	62003490	Missense_Mutation	novel	P171L	0.16
LUAD	chr3	62203914	Missense_Mutation	novel	F707L	0.16
LUAD	chr3	62078211	Missense_Mutation	NA	A190T	0.3
LUAD	chr3	62195127	Silent	NA	R428R	0.15
LUAD	chr3	61748960	Silent	rs150368253	G56G	0.67
LUAD	chr3	62132663	Missense_Mutation	NA	H226R	0.4
LUAD	chr3	62003400	Missense_Mutation	NA	G141V	0.26
LUAD	chr3	62281665	Missense_Mutation	NA	E1290K	0.38
LUAD	chr3	62267753	Nonsense_Mutation	NA	W936*	0.11
LUAD	chr3	62262745	Intron	novel		0.21
LUAD	chr3	62124570	Intron	novel		0.29
LUAD	chr3	62003384	Nonsense_Mutation	novel	G136*	0.3
LUAD	chr3	61562316	Missense_Mutation	NA	W10L	0.32
LUAD	chr3	61562345	Missense_Mutation	novel	V20L	0.23
LUAD	chr3	62271407	Missense_Mutation	NA	R1012C	0.11
LUAD	chr3	62276997	Silent	novel	A1195A	0.19
LUAD	chr3	62255171	Missense_Mutation	NA	E839K	0.42
LUSC	chr3	62124297	Intron	novel		0.15
LUSC	chr3	62124534	Intron	novel		0.14
LUSC	chr3	62218936	Missense_Mutation	novel	L747F	0.74
LUSC	chr3	62203384	Missense_Mutation	novel	P530L	0.14
LUSC	chr3	62269146	Missense_Mutation	novel	I996V	0.34
LUSC	chr3	61989760	Missense_Mutation	novel	N109I	0.2
LUSC	chr3	62281630	Missense_Mutation	novel	T1278I	0.51
LUSC	chr3	62281566	Missense_Mutation	novel	E1257K	0.14
LUSC	chr3	62267736	Missense_Mutation	NA	T931A	0.43
LUSC	chr3	62262885	Missense_Mutation	novel	I883V	0.84
LUSC	chr3	61989755	Missense_Mutation	novel	F107L	0.09
LUSC	chr3	62132659	Missense_Mutation	novel	V225L	0.67
LUSC	chr3	62201535	Missense_Mutation	NA	R453I	0.32
LUSC	chr3	61989788	Missense_Mutation	NA	K118N	0.2
OV	chr3	62271448	Missense_Mutation	novel	Q1025H	0.09
OV	chr3	61562323	Missense_Mutation	novel	L12F	0.13
OV	chr3	61748909	Silent	rs753540838	H39H	0.48
OV	chr3	62203504	Missense_Mutation	NA	P570L	0.21
OV	chr3	61989665	Missense_Mutation	NA	S77R	0.21
OV	chr3	62203224	Missense_Mutation	novel	S477T	0.07
OV	chr3	62203904	Silent	rs371158794	R703R	0.51
OV	chr3	62203430	Missense_Mutation	NA	S545R	0.32
OV	chr3	62269090	Frame_Shift_Del	novel	*I977Mfs4**	0.42
OV	chr3	61562346	Missense_Mutation	novel	V20G	0.1
OV	chr3	62195126	Frame_Shift_Del	novel	*N429Tfs26**	0.41
OV	chr3	61562244	5'UTR	novel		0.86
OV	chr3	62262804	Missense_Mutation	NA	Q856K	0.26
OV	chr3	62132643	Silent	rs149393059	H219H	0.39
OV	chr3	62273757	Missense_Mutation	novel	E1126D	0.49
PAAD	chr3	62282817	Missense_Mutation	NA	V1335I	0.1
PAAD	chr3	61562244	5'UTR	novel		0.18
PAAD	chr3	62003401	Silent	novel	G141G	0.2
PAAD	chr3	62168139	Missense_Mutation	novel	P337S	0.19
PAAD	chr3	62273803	Missense_Mutation	novel	P1142S	0.19
PAAD	chr3	62271421	Missense_Mutation	novel	R1016S	0.04
PRAD	chr3	62255175	Missense_Mutation	NA	L840R	0.34
PRAD	chr3	62124375	Intron	novel		0.31
PRAD	chr3	62271408	Missense_Mutation	rs764384969	R1012H	0.1
PRAD	chr3	62157139	Missense_Mutation	NA	Y252C	0.04
PRAD	chr3	62168097	Missense_Mutation	rs142366357	R323C	0.29
PRAD	chr3	62267717	Silent	rs758155993	T924T	0.43
READ	chr3	62262666	Intron	novel		0.2
READ	chr3	62078234	Silent	rs374241237	I197I	0.18
READ	chr3	62262632	Intron	novel		0.29
READ	chr3	62269134	Missense_Mutation	rs772358512	R992C	0.38
READ	chr3	62277035	Missense_Mutation	novel	A1208D	0.34
READ	chr3	62078249	Frame_Shift_Ins	novel	*Q205Sfs24**	0.16
SARC	chr3	62293376	3'UTR	novel		0.09
SARC	chr3	61989766	Missense_Mutation	novel	S111F	0.24
SARC	chr3	62262669	Intron	novel		0.38
SARC	chr3	62292659	Intron	novel		0.35
SARC	chr3	62262880	Missense_Mutation	novel	I881S	0.29
SARC	chr3	62203653	Nonsense_Mutation	novel	Q620*	0.18
SKCM	chr3	62168083	Missense_Mutation	rs750158140	S318F	0.31
SKCM	chr3	62167997	Silent	novel	T289T	0.29
SKCM	chr3	62271519	Missense_Mutation	rs150212631	R1049Q	0.31
SKCM	chr3	61748891	Silent	NA	G33G	0.25
SKCM	chr3	62157095	Silent	NA	V237V	0.41
SKCM	chr3	62078259	Splice_Site	novel	X205_splice	0.22
SKCM	chr3	62195131	Missense_Mutation	novel	D430N	0.3
SKCM	chr3	62203855	Missense_Mutation	NA	G687E	0.26
SKCM	chr3	62267428	Missense_Mutation	NA	K892R	0.27
SKCM	chr3	62003357	Missense_Mutation	NA	L127F	0.24
SKCM	chr3	62124242	Intron	novel		0.25
SKCM	chr3	62292648	Intron	novel		0.13
SKCM	chr3	62293238	Silent	NA	V1423V	0.32
SKCM	chr3	62191612	Missense_Mutation	NA	E393K	0.47
SKCM	chr3	62203377	Missense_Mutation	novel	S528A	0.28
SKCM	chr3	62203905	Missense_Mutation	rs565961396	G704R	0.18
SKCM	chr3	62203785	Missense_Mutation	NA	P664S	0.45
SKCM	chr3	62293161	Missense_Mutation	novel	E1398K	0.26
SKCM	chr3	62157135	Missense_Mutation	NA	R251W	0.35
SKCM	chr3	62124361	Intron	novel		0.29
SKCM	chr3	62218984	Splice_Site	NA	X763_splice	0.26
SKCM	chr3	62218879	Silent	NA	S728S	0.43
SKCM	chr3	62203767	Missense_Mutation	rs185135949	G658R	0.54
SKCM	chr3	62003422	Silent	rs140851159	V148V	0.35
SKCM	chr3	61748909	Silent	rs753540838	H39H	0.44
SKCM	chr3	62195088	Silent	rs574073526	P415P	0.48
SKCM	chr3	62124576	Intron	novel		0.37
SKCM	chr3	62157102	Missense_Mutation	novel	D240Y	0.38
SKCM	chr3	62273833	Nonsense_Mutation	NA	K1152*	0.26
SKCM	chr3	62203382	Silent	novel	F529F	0.6
SKCM	chr3	62078235	Missense_Mutation	NA	G198R	0.11
SKCM	chr3	62157163	Missense_Mutation	novel	P260L	0.38
SKCM	chr3	62203410	Missense_Mutation	novel	P539S	0.25
SKCM	chr3	62203411	Missense_Mutation	rs754408710	P539L	0.26
SKCM	chr3	62157076	Missense_Mutation	novel	T231I	0.44
SKCM	chr3	62191605	Missense_Mutation	novel	N390K	0.38
SKCM	chr3	62191606	Missense_Mutation	novel	E391K	0.38
SKCM	chr3	62124468	Intron	novel		0.16
SKCM	chr3	62271533	Missense_Mutation	novel	G1054S	0.35
SKCM	chr3	62271534	Missense_Mutation	novel	G1054D	0.34
STAD	chr3	62262968	Intron	novel		0.25
STAD	chr3	62267798	Silent	rs557054933	T951T	0.11
STAD	chr3	61989712	Missense_Mutation	NA	A93V	0.11
STAD	chr3	62203358	Silent	NA	F521F	0.19
STAD	chr3	62203824	Frame_Shift_Del	novel	*T679Pfs48**	0.27
STAD	chr3	62124476	Intron	novel		0.13
STAD	chr3	62203414	Missense_Mutation	rs779012226	T540M	0.24
STAD	chr3	62203774	Missense_Mutation	NA	R660M	0.3
STAD	chr3	62124498	Intron	novel		0.36
STAD	chr3	62195157	Silent	rs781007376	T438T	0.38
STAD	chr3	62267465	Silent	rs781276396	S904S	0.37
STAD	chr3	62195087	Missense_Mutation	NA	P415L	0.07
STAD	chr3	62218854	Frame_Shift_Del	novel	*N722Tfs5**	0.31
STAD	chr3	62277031	Missense_Mutation	NA	N1207D	0.12
STAD	chr3	62262867	Frame_Shift_Del	novel	*N878Tfs7**	0.21
STAD	chr3	62157092	Silent	rs776285819	F236F	0.28
STAD	chr3	62269068	Missense_Mutation	novel	S970C	0.26
STAD	chr3	62124285	Intron	novel		0.26
STAD	chr3	62168062	Missense_Mutation	NA	R311H	0.25
STAD	chr3	61748965	Missense_Mutation	rs376043244	P58L	0.32
STAD	chr3	61562169	5'UTR	novel		0.38
STAD	chr3	62203456	Missense_Mutation	NA	A554V	0.33
STAD	chr3	62267809	Frame_Shift_Del	novel	*G957Efs24**	0.46
STAD	chr3	62203336	Missense_Mutation	rs756672469	T514M	0.23
STAD	chr3	62132658	Silent	rs753995594	V224V	0.29
STAD	chr3	62273059	Missense_Mutation	rs749173201	R1099H	0.18
STAD	chr3	62231300	Missense_Mutation	NA	E788D	0.32
STAD	chr3	61989688	Missense_Mutation	NA	P85H	0.07
STAD	chr3	62292709	Intron	novel		0.33
STAD	chr3	62269135	Missense_Mutation	rs773599761	R992H	0.17
STAD	chr3	62272943	Splice_Region	novel		0.28
STAD	chr3	62267411	Splice_Region	NA	Y886Y	0.3
STAD	chr3	62218977	Missense_Mutation	NA	Y761C	0.41
STAD	chr3	61989723	Missense_Mutation	NA	E97K	0.22
STAD	chr3	62272961	Missense_Mutation	novel	R1066S	0.16
THCA	chr3	62275956	In_Frame_Ins	novel	S1183_V1184insFKDII	0.1
THCA	chr3	62275958	Missense_Mutation	novel	V1184D	0.07
THYM	chr3	62124525	Intron	novel		0.12
UCEC	chr3	62203678	Missense_Mutation	rs751593508	S628L	0.46
UCEC	chr3	62271502	Silent	NA	R1043R	0.4
UCEC	chr3	62231229	Missense_Mutation	NA	C765R	0.36
UCEC	chr3	62281599	Missense_Mutation	NA	E1268K	0.38
UCEC	chr3	62124245	Intron	novel		0.35
UCEC	chr3	62218942	Silent	rs376160752	F749F	0.33
UCEC	chr3	62292525	Missense_Mutation	NA	N1387S	0.47
UCEC	chr3	62195131	Missense_Mutation	novel	D430N	0.11
UCEC	chr3	62293512	3'UTR	novel		0.3
UCEC	chr3	61989715	Missense_Mutation	rs751803837	R94H	0.06
UCEC	chr3	62243871	Nonsense_Mutation	NA	E814*	0.12
UCEC	chr3	62262942	Intron	novel		0.28
UCEC	chr3	62281593	Nonsense_Mutation	NA	R1266*	0.63
UCEC	chr3	62078211	Missense_Mutation	NA	A190T	0.22
UCEC	chr3	62191641	Silent	novel	S402S	0.43
UCEC	chr3	62218854	Frame_Shift_Del	novel	*N722Tfs5**	0.6
UCEC	chr3	62293306	Nonstop_Mutation	novel	1446Lext4	0.17
UCEC	chr3	62293612	3'UTR	novel		0.39
UCEC	chr3	62293538	3'UTR	novel		0.25
UCEC	chr3	61748926	Missense_Mutation	novel	S45I	0.36
UCEC	chr3	62243862	Missense_Mutation	novel	V811I	0.36
UCEC	chr3	62267802	Missense_Mutation	novel	L953F	0.37
UCEC	chr3	62271430	Silent	novel	I1019I	0.46
UCEC	chr3	62195113	Missense_Mutation	novel	Q424K	0.1
UCEC	chr3	62203766	Silent	rs758300826	G657G	0.42
UCEC	chr3	62293612	3'UTR	novel		0.46
UCEC	chr3	62293728	3'UTR	novel		0.41
UCEC	chr3	62267442	Missense_Mutation	rs199631360	P897S	0.18
UCEC	chr3	62191643	Missense_Mutation	rs778807385	D403G	0.31
UCEC	chr3	62282794	Missense_Mutation	NA	S1327N	0.22
UCEC	chr3	62157203	Silent	rs371752893	P273P	0.5
UCEC	chr3	62281568	Silent	novel	E1257E	0.33
UCEC	chr3	61989713	Silent	rs765996492	A93A	0.23
UCEC	chr3	62203369	Missense_Mutation	NA	G525V	0.27
UCEC	chr3	61562348	Missense_Mutation	rs146419543	L21F	0.19
UCEC	chr3	62203584	Nonsense_Mutation	novel	E597*	0.1
UCEC	chr3	62262643	Intron	novel		0.38
UCEC	chr3	62267725	Missense_Mutation	novel	P927H	0.17
UCEC	chr3	62271443	Missense_Mutation	novel	T1024A	0.38
UCEC	chr3	62195157	Silent	rs781007376	T438T	0.42
UCEC	chr3	62203905	Missense_Mutation	rs565961396	G704R	0.35
UCEC	chr3	62282849	Silent	novel	G1345G	0.37
UCEC	chr3	62263004	Intron	novel		0.65
UCEC	chr3	62293612	3'UTR	novel		0.27
UCEC	chr3	62262794	Splice_Region	novel		0.36
UCEC	chr3	62262671	Intron	novel		0.33
UCEC	chr3	62275924	Nonsense_Mutation	novel	E1173*	0.48
UCEC	chr3	62293511	3'UTR	novel		0.43
UCEC	chr3	62132621	Missense_Mutation	novel	S212Y	0.42
UCEC	chr3	62168050	Missense_Mutation	novel	R307Q	0.42
UCEC	chr3	62276983	Nonsense_Mutation	NA	R1191*	0.14
UCEC	chr3	62203921	Missense_Mutation	novel	E709G	0.32
UCEC	chr3	62203180	Missense_Mutation	rs747382591	A462V	0.33
UCEC	chr3	62203472	Silent	novel	L559L	0.32
UCEC	chr3	62277606	Missense_Mutation	rs78612108	T1231M	0.21
UCEC	chr3	62293597	3'UTR	rs142945046		0.33
UCEC	chr3	62293598	3'UTR	rs567840899		0.44
UCEC	chr3	62293738	3'UTR	novel		0.39
UCEC	chr3	62132609	Missense_Mutation	rs61757808	P208L	0.28
UCEC	chr3	62195143	Missense_Mutation	rs751343662	D434N	0.37
UCEC	chr3	62203256	Missense_Mutation	novel	F487L	0.33
UCEC	chr3	62293612	3'UTR	novel		0.25
UCEC	chr3	62218881	Missense_Mutation	rs544447280	R729H	0.17
UCEC	chr3	62293612	3'UTR	novel		0.25
UCEC	chr3	62124386	Intron	novel		0.46
UCEC	chr3	62272978	Missense_Mutation	novel	V1072A	0.48
UCEC	chr3	62293597	3'UTR	rs142945046		0.43
UCEC	chr3	61562226	5'UTR	novel		0.41
UCEC	chr3	62293178	Silent	novel	I1403I	0.47
UCEC	chr3	62293730	3'UTR	novel		0.6
UCEC	chr3	62218853	Frame_Shift_Ins	NA	*N722Kfs45**	0.35
UCEC	chr3	62293612	3'UTR	novel		0.4
UCEC	chr3	62078200	Missense_Mutation	novel	S186I	0.08
UCEC	chr3	62243813	Frame_Shift_Del	novel	*Q796Rfs67**	0.38
UCEC	chr3	62262671	Intron	novel		0.35
UCEC	chr3	62255145	Missense_Mutation	novel	V830A	0.13
UCEC	chr3	62293431	3'UTR	novel		0.09
UCEC	chr3	62293612	3'UTR	novel		0.45
UCEC	chr3	61748878	Missense_Mutation	rs200002839	A29V	0.22
UCEC	chr3	62262671	Intron	novel		0.52
UCEC	chr3	62282792	Missense_Mutation	novel	I1326M	0.15
UCEC	chr3	62269073	Silent	novel	E971E	0.4
UCEC	chr3	62276977	Missense_Mutation	rs759368265	R1189C	0.41
UCEC	chr3	61989714	Missense_Mutation	rs764140516	R94C	0.31
UCEC	chr3	62271451	Nonsense_Mutation	NA	W1026*	0.27
UCEC	chr3	62195092	Missense_Mutation	novel	S417G	0.33
UCEC	chr3	62292542	Missense_Mutation	NA	V1393I	0.39
UCEC	chr3	61748912	Missense_Mutation	novel	E40D	0.37
UCEC	chr3	62191546	Missense_Mutation	novel	E371K	0.32
UCEC	chr3	62218887	Missense_Mutation	novel	A731D	0.34
UCEC	chr3	62293612	3'UTR	novel		0.36
UCEC	chr3	62168129	Missense_Mutation	novel	F333L	0.41
UCEC	chr3	62293807	3'UTR	novel		0.25
UCEC	chr3	62276983	Nonsense_Mutation	NA	R1191*	0.07
UCEC	chr3	62277616	Missense_Mutation	novel	F1234L	0.08
UCEC	chr3	62262908	Intron	novel		0.15
UCEC	chr3	62293499	3'UTR	novel		0.22
UCEC	chr3	61562295	Missense_Mutation	novel	R3M	0.21
UCEC	chr3	62124365	Intron	novel		0.33
UCEC	chr3	62293605	3'UTR	novel		0.22
UCEC	chr3	61989714	Missense_Mutation	NA	R94G	0.38
UCEC	chr3	62203779	Missense_Mutation	novel	A662T	0.19
UCEC	chr3	62243890	Missense_Mutation	NA	P820H	0.16
UCEC	chr3	62262807	Missense_Mutation	rs780222251	R857C	0.1
UCEC	chr3	62281619	Silent	novel	A1274A	0.04
UCEC	chr3	62262863	Silent	NA	K875K	0.17
UCEC	chr3	62275948	Frame_Shift_Ins	novel	*N1181Ifs14**	0.05
UCEC	chr3	62292514	Frame_Shift_Del	rs747014614	M1385*	0.25
UCEC	chr3	62293612	3'UTR	novel		0.36
UCEC	chr3	61748928	Missense_Mutation	NA	A46T	0.39
UCEC	chr3	62157171	Missense_Mutation	rs563123759	E263K	0.5
UCEC	chr3	62292543	Missense_Mutation	NA	V1393A	0.55
UCEC	chr3	62203498	Missense_Mutation	rs201733832	S568L	0.27
UCEC	chr3	62003369	Missense_Mutation	rs752539487	D131N	0.35
UCEC	chr3	62243856	Nonsense_Mutation	rs747596725	R809*	0.3
UCEC	chr3	62262938	Intron	novel		0.43
UCEC	chr3	62293331	3'UTR	novel		0.1
UCEC	chr3	61989653	Silent	rs187568366	T73T	0.3
UCEC	chr3	62231268	Missense_Mutation	rs773451436	R778C	0.3
UCEC	chr3	62203237	Missense_Mutation	rs376270678	T481M	0.11
UCEC	chr3	62262608	Intron	novel		0.56
UCEC	chr3	62262928	Intron	rs200577266		0.37
UCEC	chr3	62292428	Missense_Mutation	novel	A1355S	0.16
UCEC	chr3	61562230	5'UTR	novel		0.18
UCEC	chr3	62078162	Splice_Site	novel	X174_splice	0.34
UCEC	chr3	62271408	Missense_Mutation	rs764384969	R1012H	0.32
UCEC	chr3	62293389	3'UTR	novel		0.41
UCEC	chr3	62124310	Intron	novel		0.36
UCEC	chr3	62293612	3'UTR	novel		0.3
UCEC	chr3	62218854	Frame_Shift_Del	novel	*N722Tfs5**	0.47
UCEC	chr3	62262572	Intron	novel		0.42
UCEC	chr3	62277633	Missense_Mutation	novel	D1240G	0.35
UCEC	chr3	62269138	Missense_Mutation	rs771320696	R993H	0.47
UCEC	chr3	62293169	Silent	rs760713322	Y1400Y	0.31
UCEC	chr3	62293350	3'UTR	novel		0.52
UCS	chr3	62203181	Silent	rs757781094	A462A	0.35
UCS	chr3	62273770	Nonsense_Mutation	novel	Q1131*	0.75
UVM	chr3	61562368	Splice_Site	novel	X28_splice	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.75	0.016387
HNSC	DEL	0.6533	1.1594e-06
LUAD	DEL	0.3333	0.0021265
PAAD	DEL	0.1848	0.030662
SARC	DEL	0.1868	0.0034746
SKCM	DEL	0.1417	0.13887
TGCT	AMP	0.18	0.23596
THYM	DEL	0.0976	0.037527
UVM	DEL	0.5375	0.09134

Survival Analysis

Cancer	P-value	Q-value
SARC	0.00023	Kaplan-Meier Survival Analysis
MESO	0.0032	Kaplan-Meier Survival Analysis
SKCM	0.044	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
KIRP	0.02	Kaplan-Meier Survival Analysis
COAD	0.046	Kaplan-Meier Survival Analysis
BLCA	0.0096	Kaplan-Meier Survival Analysis
READ	0.03	Kaplan-Meier Survival Analysis
LAML	0.013	Kaplan-Meier Survival Analysis
KICH	0.019	Kaplan-Meier Survival Analysis
LUAD	0.045	Kaplan-Meier Survival Analysis
UVM	0.049	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000144724 (Gene tree)
Gene ID: 5793
Gene Symbol: PTPRG
Alias: RPTPG|PTPG
Full Name: protein tyrosine phosphatase receptor type G
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 736,045 bases
Position: chr3:61,561,569-62,297,613
Accession: 9671
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000485215	PTPRG-206	724	-	-	- (aa)	-	-
ENST00000495879	PTPRG-207	3011	-	-	- (aa)	-	-
ENST00000295874	PTPRG-201	4650	XM_005265353	ENSP00000295874	1416 (aa)	XP_005265410	P23470
ENST00000468576	PTPRG-202	854	-	-	- (aa)	-	-
ENST00000475012	PTPRG-204	2635	-	-	- (aa)	-	-
ENST00000475527	PTPRG-205	2694	-	-	- (aa)	-	-
ENST00000474889	PTPRG-203	9021	XM_017006961	ENSP00000418112	1445 (aa)	XP_016862450	P23470

Gene Model

Click here to download ENSG00000144724's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000144724	Lipids	5.32831414289751E-6	17903299
ENSG00000144724	Hip	1.2101855243664E-5	17903296
ENSG00000144724	Diabetes Mellitus, Type 2	7.185084E-5	17463248
ENSG00000144724	Body Mass Index	9.638e-005	19060910
ENSG00000144724	C-Reactive Protein	2.522e-005	19060910
ENSG00000144724	Platelet Count	9.881e-005	-
ENSG00000144724	Triglycerides	9.325e-005	-
ENSG00000144724	Personality	8.812e-005	-
ENSG00000144724	Waist Circumference	9.8070000E-005	-
ENSG00000144724	Waist Circumference	3.4690000E-006	-
ENSG00000144724	Arteries	3.0990000E-005	-
ENSG00000144724	Blood Glucose	9.5690000E-005	-
ENSG00000144724	Cell Adhesion Molecules	3.8120000E-005	-
ENSG00000144724	Platelet Function Tests	1.4338700E-005	-
ENSG00000144724	Platelet Function Tests	1.5991000E-005	-
ENSG00000144724	Platelet Function Tests	4.8800000E-006	-
ENSG00000144724	Platelet Function Tests	1.3316800E-005	-
ENSG00000144724	Platelet Function Tests	1.1550200E-005	-
ENSG00000144724	Platelet Function Tests	2.3210200E-005	-
ENSG00000144724	Platelet Function Tests	2.5084200E-005	-
ENSG00000144724	Platelet Function Tests	2.2060100E-005	-
ENSG00000144724	Fluorescence	8.2610000E-006	24934506
ENSG00000144724	Electrocardiography	8E-7	20031603
ENSG00000144724	Alzheimer Disease	4E-8	26830138
ENSG00000144724	Age of Onset	4E-8	26830138
ENSG00000144724	Stroke	7E-7	26089329
ENSG00000144724	Stroke	6E-7	26089329
ENSG00000144724	Schizophrenia	2E-6	21926974
ENSG00000144724	Homovanillic Acid	5E-6	23319000
ENSG00000144724	Hydroxyindoleacetic Acid	5E-6	23319000
ENSG00000144724	Stroke	6E-7	26089329
ENSG00000144724	Bacteremia	1E-7	27236921
ENSG00000144724	Stroke	7E-7	26089329
ENSG00000144724	Attention Deficit Disorder with Hyperactivity	8E-7	27890468
ENSG00000144724	Bipolar Disorder	8E-7	27890468
ENSG00000144724	Fuchs' Endothelial Dystrophy	1E-6	20825314

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000144724	rs7633054	3	62153280	?	Bacteremia	27236921	[NR]	1.36	EFO_0003033
ENSG00000144724	rs13061878	3	61634560	?	Bipolar disorder or attention deficit hyperactivity disorder	27890468			EFO_0003888\|EFO_0000289
ENSG00000144724	rs7609954	3	61650482	T	Alzheimer disease and age of onset	26830138	unit increase	5.492	EFO_0000249\|EFO_0004847
ENSG00000144724	rs704341	3	61963062	A	Stroke	26089329	[1.40-2.14]	1.73	EFO_0000712
ENSG00000144724	rs704341	3	61963062	A	Stroke	26089329	[0.33-0.77] unit increase	0.55	EFO_0000712
ENSG00000144724	rs704341	3	61963062	A	Ischemic stroke	26089329	[1.45-2.36]	1.85	HP_0002140
ENSG00000144724	rs704341	3	61963062	A	Ischemic stroke	26089329	[0.38-0.86] unit increase	0.62	HP_0002140
ENSG00000144724	rs652889	3	61808380	A	QT interval	20031603	[0.09-0.21] unit decrease	0.15	EFO_0004682
ENSG00000144724	rs35593266	3	62126467	A	Metabolite levels (HVA/5-HIAA ratio)	23319000	unit increase	0.2196	EFO_0005131\|EFO_0005132
ENSG00000144724	rs40493	3	61989275	C	Major depressive disorder	29317602	[0.071-0.189] unit increase	0.13	EFO_0003761
ENSG00000144724	rs4688651	3	61651395	A	Osteoarthritis (self-reported)	29559693	[1.14-1.1]	1.0981276	EFO_0002506
ENSG00000144724	rs11130874	3	62079095	?	Schizophrenia	21926974	[1.06-1.14]	1.1	EFO_0000692
ENSG00000144724	rs10490775	3	62051050	A	Fuchs's corneal dystrophy	20825314	[1.64-3.22]	2.3	Orphanet_98974
ENSG00000144724	rs660323	3	61776956	?	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[4.72-6.44]	5.58	EFO_0004265\|EFO_0007908
ENSG00000144724	rs6445258	3	62126524	?	Body mass index	30595370			EFO_0004340
ENSG00000144724	rs7621604	3	61572044	?	Waist-hip ratio	30595370			EFO_0004343

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144724's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004725	protein tyrosine phosphatase activity	19167335.	IDA	Function
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	8382771.	TAS	Function
GO:0005515	protein binding	19167335.21112398.25970784.	IPI	Function
GO:0005887	integral component of plasma membrane	8382771.	TAS	Component
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	8382771.	TAS	Process
GO:0007420	brain development	-	IEA	Process
GO:0010633	negative regulation of epithelial cell migration	21724833.	IMP	Process
GO:0010977	negative regulation of neuron projection development	-	IEA	Process
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IEA	Process
GO:0042802	identical protein binding	19167335.	IPI	Function
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:1903385	regulation of homophilic cell adhesion	21724833.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.