EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24727246	Rab'ing tumor cell migration and invasion: focal adhesion disassembly driven by Rab5.	Cell Adh Migr	2014	Torres VA	-
25763873	Rab5 activation as a tumor cell migration switch.	Small GTPases	2014	Mendoza P	doi: 10.4161/sgtp.28195.
26528697	CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.	Oncotarget	2015 Dec 1	Liu B	doi: 10.18632/oncotarget.5732.
26261586	Increased expression of Rab5A predicts metastasis and poor prognosis in colorectal cancer patients.	Int J Clin Exp Pathol	2015 Jun 1	Yu MH	-
26473288	Endosomal gene expression: a new indicator for prostate cancer patient prognosis?	Oncotarget	2015 Nov 10	Johnson IR	doi: 10.18632/oncotarget.6114.
21500550	[The expression and clinical significance of RABEX-5 and RAB5 in breast cancer].	Sichuan Da Xue Xue Bao Yi Xue Ban	2011 Mar	Wang YJ	-
23291133	[Expression and significance of Rab5a and APPL1 in breast cancer].	Zhonghua Zhong Liu Za Zhi	2012 Nov	Chen Q	doi: 10.3760/cma.j.issn.0253-3766.2012.11.009.
26443539	Overexpression of Rab5a promotes hepatocellular carcinoma cell proliferation and invasion via FAK signaling pathway.	Tumour Biol	2016 Mar	Geng D	doi: 10.1007/s13277-015-4124-5
23813952	Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.	J Cell Sci	2013 Sep 1	Mendoza P	doi: 10.1242/jcs.119727
21849022	Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway.	J Biomed Sci	2011 Aug 17	Liu SS	doi: 10.1186/1423-0127-18-58.
20412119	Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with APPL1-related epidermal growth factor signaling pathway.	Cancer Sci	2010 Jun	Zhao Z	doi: 10.1111/j.1349-7006.2010.01558.x
21895870	Rab5A is associated with axillary lymph node metastasis in breast cancer patients.	Cancer Sci	2011 Dec	Yang PS	doi: 10.1111/j.1349-7006.2011.02089.x
27867015	CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer.	Cancer Lett	2017 Feb 1	Yuan W	doi: 10.1016/j.canlet.2016.11.015
28243729	Expression of Rab5a correlates with tumor progression in pancreatic carcinoma.	Virchows Arch	2017 May	Li Y	doi: 10.1007/s00428-017-2098-y
28849149	Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling.	Mol Med Rep	2017 Oct	Zhang D	doi: 10.3892/mmr.2017.7214
28742203	Expression levels and roles of EMC-6, Beclin1, and Rab5a in the cervical cancer.	Eur Rev Med Pharmacol Sci	2017 Jul	Shen MX	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	19978323	Missense_Mutation	NA	Y151S	0.45
BLCA	chr3	19983806	Nonsense_Mutation	novel	Q211*	0.17
BLCA	chr3	19976051	Missense_Mutation	novel	S107F	0.38	MMR_HSR1
BLCA	chr3	19950909	Missense_Mutation	novel	R4P	0.14
CESC	chr3	19985091	3'UTR	novel		0.29
CESC	chr3	19976170	Splice_Site	NA	X146_splice	0.36
COAD	chr3	19976070	Missense_Mutation	NA	N113K	0.09	MMR_HSR1
COAD	chr3	19976135	Missense_Mutation	NA	A135V	0.34
COAD	chr3	19976143	Missense_Mutation	rs760110691	A138T	0.22
COAD	chr3	19976149	Missense_Mutation	NA	K140E	0.51
COAD	chr3	19976067	Silent	NA	K112K	0.22
ESCA	chr3	19978397	Missense_Mutation	novel	A176T	0.34
GBM	chr3	19983746	Missense_Mutation	novel	A191S	0.12
HNSC	chr3	19976161	Missense_Mutation	novel	D144N	0.16
HNSC	chr3	19983770	Missense_Mutation	novel	V199I	0.33
HNSC	chr3	19976059	Nonsense_Mutation	novel	R110*	0.33	MMR_HSR1
LUAD	chr3	19976097	Silent	rs145181037	A122A	0.39
LUAD	chr3	19978348	Silent	novel	F159F	0.14
LUAD	chr3	19975669	Missense_Mutation	NA	G78R	0.33	MMR_HSR1
LUAD	chr3	19978396	Missense_Mutation	NA	M175I	0.55
LUSC	chr3	19978349	Missense_Mutation	novel	M160V	0.3
LUSC	chr3	19975654	Missense_Mutation	novel	I73V	0.72	MMR_HSR1
OV	chr3	19975741	Missense_Mutation	novel	I102F	0.08	MMR_HSR1
PAAD	chr3	19950913	Silent	rs111819761	G5G	0.18
READ	chr3	19975705	Missense_Mutation	NA	Y90N	0.09	MMR_HSR1
READ	chr3	19976070	Missense_Mutation	NA	N113K	0.37	MMR_HSR1
SARC	chr3	19984427	3'UTR	NA		0.1
SKCM	chr3	19950928	Silent	rs749885739	N10N	0.15
SKCM	chr3	19983740	Missense_Mutation	NA	P189S	0.14
SKCM	chr3	19975724	Missense_Mutation	novel	A96V	0.19	MMR_HSR1
SKCM	chr3	19975725	Silent	novel	A96A	0.2
SKCM	chr3	19950888	5'UTR	novel		0.54
STAD	chr3	19976064	Frame_Shift_Del	novel	*N113Ifs15**	0.22	MMR_HSR1
STAD	chr3	19976070	Missense_Mutation	NA	N113K	0.07	MMR_HSR1
STAD	chr3	19975601	Missense_Mutation	novel	A55V	0.21	MMR_HSR1
STAD	chr3	19976099	Missense_Mutation	novel	S123N	0.36	MMR_HSR1
THYM	chr3	19984415	3'UTR	novel		0.67
UCEC	chr3	19985077	3'UTR	novel		0.37
UCEC	chr3	19950864	5'UTR	novel		0.15
UCEC	chr3	19970682	Intron	novel		0.42
UCEC	chr3	19978403	Missense_Mutation	novel	A178S	0.26
UCEC	chr3	19976049	Splice_Region	rs759467773	E106E	0.39
UCEC	chr3	19984647	3'UTR	novel		0.33
UCEC	chr3	19970575	Intron	novel		0.16
UCEC	chr3	19984822	3'UTR	novel		0.1
UCEC	chr3	19976164	Missense_Mutation	NA	F145V	0.23
UCEC	chr3	19950881	5'UTR	rs777711883		0.25
UCEC	chr3	19950999	Missense_Mutation	NA	S34L	0.25	MMR_HSR1
UCEC	chr3	19984415	3'UTR	novel		0.41
UCEC	chr3	19985007	3'UTR	novel		0.32
UCEC	chr3	19984822	3'UTR	novel		0.36
UCEC	chr3	19984734	3'UTR	novel		0.18
UCEC	chr3	19951014	Missense_Mutation	novel	R39H	0.24	MMR_HSR1
UCEC	chr3	19976137	Missense_Mutation	rs749601586	D136N	0.16
UCEC	chr3	19970574	Intron	novel		0.33
UCEC	chr3	19984174	3'UTR	novel		0.3
UCEC	chr3	19970646	Intron	novel		0.31
UCEC	chr3	19950971	Missense_Mutation	novel	L25I	0.52	MMR_HSR1
UCEC	chr3	19976137	Missense_Mutation	rs749601586	D136N	0.17
UCEC	chr3	19985049	3'UTR	novel		0.41
UCEC	chr3	19950864	5'UTR	novel		0.31
UCEC	chr3	19978403	Missense_Mutation	novel	A178S	0.48
UCEC	chr3	19984287	3'UTR	novel		0.38
UCEC	chr3	19984669	3'UTR	novel		0.43
UCEC	chr3	19983984	3'UTR	novel		0.48
UCEC	chr3	19950914	Missense_Mutation	rs144198452	A6T	0.18
UCEC	chr3	19950837	5'UTR	novel		0.68
UCEC	chr3	19975667	Missense_Mutation	novel	A77V	0.2	MMR_HSR1
UCEC	chr3	19984347	3'UTR	novel		0.39
UCEC	chr3	19950971	Missense_Mutation	novel	L25I	0.36	MMR_HSR1
UCEC	chr3	19978318	Silent	novel	Q149Q	0.41
UCEC	chr3	19984237	3'UTR	novel		0.12
UCEC	chr3	19983999	3'UTR	novel		0.55
UCEC	chr3	19984172	3'UTR	novel		0.31
UCEC	chr3	19951025	Missense_Mutation	novel	G43C	0.3	MMR_HSR1
UCEC	chr3	19984030	3'UTR	novel		0.45
UCEC	chr3	19950843	5'UTR	novel		0.31
UCEC	chr3	19984414	3'UTR	rs569586973		0.25
UCEC	chr3	19970575	Intron	novel		0.17
UCEC	chr3	19984350	3'UTR	novel		0.44
UCEC	chr3	19984987	3'UTR	novel		0.31
UCEC	chr3	19970684	Intron	novel		0.29
UCEC	chr3	19970663	Intron	novel		0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.7222	0.02241
COAD	DEL	0.1242	0.010931
LUAD	DEL	0.3217	0.068154
SKCM	DEL	0.1635	0.13887
TGCT	DEL	0.2	0.08422
THYM	DEL	0.0894	0.037527

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0011	Kaplan-Meier Survival Analysis
MESO	0.025	Kaplan-Meier Survival Analysis
SKCM	0.025	Kaplan-Meier Survival Analysis
LUSC	0.047	Kaplan-Meier Survival Analysis
PAAD	0.0036	Kaplan-Meier Survival Analysis
KICH	0.043	Kaplan-Meier Survival Analysis
LGG	0.037	Kaplan-Meier Survival Analysis
UVM	0.00074	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000144566 (Gene tree)
Gene ID: 5868
Gene Symbol: RAB5A
Alias: RAB5
Full Name: RAB5A, member RAS oncogene family
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 38,097 bases
Position: chr3:19,947,079-19,985,175
Accession: 9783
Summary: RAB5A (RAB5A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5A include Motor Neuron Disease and Spinocerebellar Ataxia 11. Among its related pathways are RAB geranylgeranylation and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000273047	MMR_HSR1	PF01926.23	0.00034	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29130360	Autophagy and innate immunity: Insights from invertebrate model organisms.	Autophagy	2018	Kuo CJ	doi: 10.1080/15548627.2017.1389824
18981233	Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6.	J Cell Biol	2008 Nov 3	Semerdjieva S	doi: 10.1083/jcb.200806016.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000469122	RAB5A-206	918	-	-	- (aa)	-	-
ENST00000446547	RAB5A-205	1358	-	ENSP00000396632	65 (aa)	-	F8WD79
ENST00000476544	RAB5A-208	532	-	-	- (aa)	-	-
ENST00000443878	RAB5A-204	753	-	ENSP00000398450	15 (aa)	-	C9J3X8
ENST00000273047	RAB5A-201	2536	-	ENSP00000273047	215 (aa)	-	P20339
ENST00000412966	RAB5A-202	622	-	ENSP00000403533	62 (aa)	-	F8WCY6
ENST00000473608	RAB5A-207	868	-	-	- (aa)	-	-
ENST00000422242	RAB5A-203	1443	-	ENSP00000411941	201 (aa)	-	P20339

Gene Model

Click here to download ENSG00000144566's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04014	Ras signaling pathway	KEGG
hsa04144	Endocytosis	KEGG
hsa04145	Phagosome	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05014	Amyotrophic lateral sclerosis (ALS)	KEGG
hsa05146	Amoebiasis	KEGG
hsa05152	Tuberculosis	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000144566	Platelet Function Tests	6.1800000E-006	-
ENSG00000144566	Platelet Function Tests	7.1400000E-006	-
ENSG00000144566	Vitamin B 12	4.6500000E-005	-
ENSG00000144566	Vitamin B 12	1.9610000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000144566	rs146206942	3	19957364	?	Heel bone mineral density	30048462	[0.058-0.095] unit increase	0.076553	EFO_0009270
ENSG00000144566	rs115814778	3	19982367	G	Heel bone mineral density	30598549	[0.038-0.07] unit increase	0.0541169	EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144566's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144566	RAB5A	100	91.667	ENSAPOG00000021391	rab5aa	100	91.667	Acanthochromis_polyacanthus
ENSG00000144566	RAB5A	100	99.070	ENSAMEG00000000954	RAB5A	100	99.070	Ailuropoda_melanoleuca
ENSG00000144566	RAB5A	100	92.130	ENSACIG00000019251	rab5aa	100	92.130	Amphilophus_citrinellus
ENSG00000144566	RAB5A	100	92.593	ENSAOCG00000000090	rab5aa	100	92.593	Amphiprion_ocellaris
ENSG00000144566	RAB5A	100	92.593	ENSAPEG00000013376	rab5aa	100	92.593	Amphiprion_percula
ENSG00000144566	RAB5A	100	92.130	ENSATEG00000014748	rab5aa	100	92.130	Anabas_testudineus
ENSG00000144566	RAB5A	100	95.349	ENSACAG00000000017	RAB5A	100	95.349	Anolis_carolinensis
ENSG00000144566	RAB5A	100	99.070	ENSANAG00000025120	RAB5A	100	99.070	Aotus_nancymaae
ENSG00000144566	RAB5A	100	92.593	ENSACLG00000018066	rab5aa	100	92.593	Astatotilapia_calliptera
ENSG00000144566	RAB5A	100	91.667	ENSAMXG00000036179	rab5aa	100	91.667	Astyanax_mexicanus
ENSG00000144566	RAB5A	100	89.862	ENSAMXG00000035919	rab5ab	100	89.862	Astyanax_mexicanus
ENSG00000144566	RAB5A	100	98.605	ENSBTAG00000046385	RAB5A	100	98.605	Bos_taurus
ENSG00000144566	RAB5A	100	99.070	ENSCJAG00000048394	RAB5A	100	99.070	Callithrix_jacchus
ENSG00000144566	RAB5A	100	99.070	ENSCAFG00000005814	RAB5A	100	99.070	Canis_familiaris
ENSG00000144566	RAB5A	100	99.070	ENSCAFG00020027287	RAB5A	100	99.070	Canis_lupus_dingo
ENSG00000144566	RAB5A	100	98.140	ENSCHIG00000025419	-	100	98.140	Capra_hircus
ENSG00000144566	RAB5A	100	99.535	ENSTSYG00000007642	-	100	99.535	Carlito_syrichta
ENSG00000144566	RAB5A	100	93.488	ENSTSYG00000030238	-	100	93.488	Carlito_syrichta
ENSG00000144566	RAB5A	100	99.070	ENSCCAG00000022405	RAB5A	100	99.070	Cebus_capucinus
ENSG00000144566	RAB5A	100	99.070	ENSCATG00000033588	-	100	99.070	Cercocebus_atys
ENSG00000144566	RAB5A	100	99.070	ENSCLAG00000006053	-	100	99.070	Chinchilla_lanigera
ENSG00000144566	RAB5A	100	99.070	ENSCSAG00000009831	RAB5A	100	99.070	Chlorocebus_sabaeus
ENSG00000144566	RAB5A	100	95.349	ENSCPBG00000022559	RAB5A	100	95.349	Chrysemys_picta_bellii
ENSG00000144566	RAB5A	100	99.070	ENSCANG00000043514	RAB5A	100	99.070	Colobus_angolensis_palliatus
ENSG00000144566	RAB5A	100	98.140	ENSCGRG00001020018	-	100	98.140	Cricetulus_griseus_chok1gshd
ENSG00000144566	RAB5A	100	98.140	ENSCGRG00000002786	-	100	98.140	Cricetulus_griseus_crigri
ENSG00000144566	RAB5A	99	92.558	ENSCVAG00000008239	rab5aa	99	92.558	Cyprinodon_variegatus
ENSG00000144566	RAB5A	100	92.593	ENSDARG00000018602	rab5aa	100	92.593	Danio_rerio
ENSG00000144566	RAB5A	99	92.093	ENSDARG00000007257	rab5ab	99	92.093	Danio_rerio
ENSG00000144566	RAB5A	100	98.605	ENSDNOG00000038467	RAB5A	100	98.605	Dasypus_novemcinctus
ENSG00000144566	RAB5A	100	99.070	ENSDORG00000024958	-	100	99.070	Dipodomys_ordii
ENSG00000144566	RAB5A	100	98.605	ENSEASG00005005818	RAB5A	100	98.605	Equus_asinus_asinus
ENSG00000144566	RAB5A	100	99.070	ENSECAG00000019062	RAB5A	100	99.070	Equus_caballus
ENSG00000144566	RAB5A	100	98.140	ENSEEUG00000009044	RAB5A	100	98.140	Erinaceus_europaeus
ENSG00000144566	RAB5A	100	93.056	ENSELUG00000006462	rab5aa	100	93.056	Esox_lucius
ENSG00000144566	RAB5A	99	92.558	ENSELUG00000013436	rab5ab	99	92.558	Esox_lucius
ENSG00000144566	RAB5A	100	99.070	ENSFCAG00000039795	-	100	99.070	Felis_catus
ENSG00000144566	RAB5A	100	95.814	ENSFALG00000009239	RAB5A	100	95.814	Ficedula_albicollis
ENSG00000144566	RAB5A	100	98.140	ENSFDAG00000005631	-	100	98.140	Fukomys_damarensis
ENSG00000144566	RAB5A	99	92.558	ENSFHEG00000014070	rab5aa	99	92.558	Fundulus_heteroclitus
ENSG00000144566	RAB5A	99	90.698	ENSGMOG00000002868	rab5aa	99	90.698	Gadus_morhua
ENSG00000144566	RAB5A	94	88.136	ENSGMOG00000007127	RAB5A	99	93.370	Gadus_morhua
ENSG00000144566	RAB5A	100	95.814	ENSGALG00000011272	RAB5A	100	95.814	Gallus_gallus
ENSG00000144566	RAB5A	99	93.488	ENSGAFG00000011619	rab5aa	99	93.488	Gambusia_affinis
ENSG00000144566	RAB5A	100	90.741	ENSGACG00000004997	rab5aa	100	90.741	Gasterosteus_aculeatus
ENSG00000144566	RAB5A	100	95.814	ENSGAGG00000005319	RAB5A	100	95.814	Gopherus_agassizii
ENSG00000144566	RAB5A	100	100.000	ENSGGOG00000015981	RAB5A	100	100.000	Gorilla_gorilla
ENSG00000144566	RAB5A	100	92.593	ENSHBUG00000003752	rab5aa	100	92.593	Haplochromis_burtoni
ENSG00000144566	RAB5A	97	99.519	ENSHGLG00000006357	-	100	99.519	Heterocephalus_glaber_female
ENSG00000144566	RAB5A	99	90.654	ENSHGLG00000017749	-	97	90.654	Heterocephalus_glaber_female
ENSG00000144566	RAB5A	99	90.654	ENSHGLG00100008816	-	97	90.654	Heterocephalus_glaber_male
ENSG00000144566	RAB5A	100	99.070	ENSHGLG00100007553	RAB5A	100	99.070	Heterocephalus_glaber_male
ENSG00000144566	RAB5A	100	89.862	ENSIPUG00000023392	rab5a	100	89.862	Ictalurus_punctatus
ENSG00000144566	RAB5A	100	98.605	ENSSTOG00000026229	RAB5A	100	98.605	Ictidomys_tridecemlineatus
ENSG00000144566	RAB5A	100	96.279	ENSJJAG00000020190	Rab5a	100	96.279	Jaculus_jaculus
ENSG00000144566	RAB5A	100	93.056	ENSKMAG00000005111	rab5aa	100	93.056	Kryptolebias_marmoratus
ENSG00000144566	RAB5A	98	92.857	ENSLBEG00000002516	rab5aa	93	92.857	Labrus_bergylta
ENSG00000144566	RAB5A	100	93.981	ENSLACG00000004663	RAB5A	100	93.981	Latimeria_chalumnae
ENSG00000144566	RAB5A	100	93.519	ENSLOCG00000006591	rab5ab	100	93.519	Lepisosteus_oculatus
ENSG00000144566	RAB5A	100	98.605	ENSLAFG00000008321	RAB5A	100	98.605	Loxodonta_africana
ENSG00000144566	RAB5A	100	99.070	ENSMFAG00000002326	RAB5A	100	99.070	Macaca_fascicularis
ENSG00000144566	RAB5A	94	93.103	ENSMMUG00000006992	RAB5A	91	98.883	Macaca_mulatta
ENSG00000144566	RAB5A	94	93.103	ENSMMUG00000032398	-	87	94.631	Macaca_mulatta
ENSG00000144566	RAB5A	100	99.070	ENSMNEG00000039149	-	100	99.070	Macaca_nemestrina
ENSG00000144566	RAB5A	100	99.070	ENSMLEG00000028944	RAB5A	100	99.070	Mandrillus_leucophaeus
ENSG00000144566	RAB5A	100	92.593	ENSMAMG00000012573	rab5aa	100	92.593	Mastacembelus_armatus
ENSG00000144566	RAB5A	100	92.593	ENSMZEG00005005205	rab5aa	100	92.593	Maylandia_zebra
ENSG00000144566	RAB5A	100	96.279	ENSMGAG00000010961	RAB5A	100	96.279	Meleagris_gallopavo
ENSG00000144566	RAB5A	100	98.140	ENSMAUG00000011242	-	100	98.140	Mesocricetus_auratus
ENSG00000144566	RAB5A	100	99.070	ENSMICG00000049130	RAB5A	100	99.070	Microcebus_murinus
ENSG00000144566	RAB5A	100	97.674	ENSMOCG00000009706	Rab5a	100	97.674	Microtus_ochrogaster
ENSG00000144566	RAB5A	100	92.130	ENSMMOG00000019135	rab5aa	100	92.130	Mola_mola
ENSG00000144566	RAB5A	100	97.674	ENSMODG00000014793	RAB5A	100	97.674	Monodelphis_domestica
ENSG00000144566	RAB5A	100	91.204	ENSMALG00000014929	rab5aa	100	91.204	Monopterus_albus
ENSG00000144566	RAB5A	100	98.140	MGP_CAROLIEiJ_G0021741	Rab5a	100	98.140	Mus_caroli
ENSG00000144566	RAB5A	100	98.140	ENSMUSG00000017831	Rab5a	100	98.140	Mus_musculus
ENSG00000144566	RAB5A	94	93.103	MGP_PahariEiJ_G0020730	Rab5a	99	95.699	Mus_pahari
ENSG00000144566	RAB5A	100	99.070	ENSMPUG00000013147	RAB5A	100	99.070	Mustela_putorius_furo
ENSG00000144566	RAB5A	100	99.070	ENSMLUG00000011716	RAB5A	100	99.070	Myotis_lucifugus
ENSG00000144566	RAB5A	100	98.140	ENSNGAG00000021245	-	100	98.140	Nannospalax_galili
ENSG00000144566	RAB5A	100	92.593	ENSNBRG00000011763	rab5aa	100	92.593	Neolamprologus_brichardi
ENSG00000144566	RAB5A	100	99.535	ENSNLEG00000003434	RAB5A	100	99.535	Nomascus_leucogenys
ENSG00000144566	RAB5A	94	93.103	ENSOPRG00000011278	RAB5A	100	98.870	Ochotona_princeps
ENSG00000144566	RAB5A	87	92.593	ENSODEG00000019065	-	100	88.947	Octodon_degus
ENSG00000144566	RAB5A	94	93.103	ENSODEG00000000290	-	99	99.315	Octodon_degus
ENSG00000144566	RAB5A	100	92.593	ENSONIG00000002425	rab5aa	100	92.593	Oreochromis_niloticus
ENSG00000144566	RAB5A	99	96.698	ENSOANG00000004989	RAB5A	97	96.698	Ornithorhynchus_anatinus
ENSG00000144566	RAB5A	100	98.605	ENSOCUG00000012200	RAB5A	100	98.605	Oryctolagus_cuniculus
ENSG00000144566	RAB5A	100	91.667	ENSORLG00000012261	rab5aa	100	91.667	Oryzias_latipes
ENSG00000144566	RAB5A	100	91.667	ENSORLG00020020922	rab5aa	100	91.667	Oryzias_latipes_hni
ENSG00000144566	RAB5A	100	91.667	ENSORLG00015012854	rab5aa	100	91.667	Oryzias_latipes_hsok
ENSG00000144566	RAB5A	100	91.204	ENSORLG00015017737	rab5ab	100	91.204	Oryzias_latipes_hsok
ENSG00000144566	RAB5A	100	92.593	ENSOMEG00000010692	rab5aa	100	92.593	Oryzias_melastigma
ENSG00000144566	RAB5A	100	98.140	ENSOARG00000015722	RAB5A	100	98.140	Ovis_aries
ENSG00000144566	RAB5A	100	99.537	ENSPPAG00000041763	RAB5A	100	99.537	Pan_paniscus
ENSG00000144566	RAB5A	100	99.070	ENSPPRG00000001655	-	100	99.070	Panthera_pardus
ENSG00000144566	RAB5A	100	99.070	ENSPTIG00000021685	RAB5A	100	99.070	Panthera_tigris_altaica
ENSG00000144566	RAB5A	100	99.537	ENSPTRG00000014682	RAB5A	100	99.537	Pan_troglodytes
ENSG00000144566	RAB5A	100	99.070	ENSPANG00000001328	RAB5A	100	99.070	Papio_anubis
ENSG00000144566	RAB5A	100	88.426	ENSPKIG00000010291	RAB5A	100	88.426	Paramormyrops_kingsleyae
ENSG00000144566	RAB5A	100	93.519	ENSPKIG00000009578	rab5ab	100	93.519	Paramormyrops_kingsleyae
ENSG00000144566	RAB5A	100	96.279	ENSPSIG00000007157	RAB5A	100	96.279	Pelodiscus_sinensis
ENSG00000144566	RAB5A	100	91.667	ENSPMGG00000001915	rab5aa	100	91.667	Periophthalmus_magnuspinnatus
ENSG00000144566	RAB5A	100	98.605	ENSPCIG00000018321	RAB5A	100	98.605	Phascolarctos_cinereus
ENSG00000144566	RAB5A	99	93.953	ENSPFOG00000011263	rab5aa	99	93.953	Poecilia_formosa
ENSG00000144566	RAB5A	99	93.953	ENSPLAG00000017838	rab5aa	99	93.953	Poecilia_latipinna
ENSG00000144566	RAB5A	99	93.953	ENSPMEG00000007238	rab5aa	99	93.953	Poecilia_mexicana
ENSG00000144566	RAB5A	100	99.535	ENSPPYG00000014074	RAB5A	100	99.535	Pongo_abelii
ENSG00000144566	RAB5A	100	99.070	ENSPCOG00000013289	RAB5A	100	99.070	Propithecus_coquereli
ENSG00000144566	RAB5A	100	98.605	ENSPVAG00000006730	RAB5A	100	98.605	Pteropus_vampyrus
ENSG00000144566	RAB5A	100	92.593	ENSPNYG00000010612	rab5aa	100	92.593	Pundamilia_nyererei
ENSG00000144566	RAB5A	100	91.667	ENSPNAG00000023223	rab5aa	100	91.667	Pygocentrus_nattereri
ENSG00000144566	RAB5A	100	89.862	ENSPNAG00000009496	rab5ab	100	89.862	Pygocentrus_nattereri
ENSG00000144566	RAB5A	100	99.070	ENSRBIG00000036122	RAB5A	100	99.070	Rhinopithecus_bieti
ENSG00000144566	RAB5A	100	99.070	ENSRROG00000037687	RAB5A	100	99.070	Rhinopithecus_roxellana
ENSG00000144566	RAB5A	100	98.148	ENSSHAG00000006787	RAB5A	100	98.148	Sarcophilus_harrisii
ENSG00000144566	RAB5A	98	91.943	ENSSFOG00015021115	-	98	91.943	Scleropages_formosus
ENSG00000144566	RAB5A	100	93.519	ENSSFOG00015014517	rab5a	100	93.519	Scleropages_formosus
ENSG00000144566	RAB5A	100	92.130	ENSSMAG00000009229	rab5aa	100	92.130	Scophthalmus_maximus
ENSG00000144566	RAB5A	100	92.593	ENSSDUG00000009835	rab5aa	100	92.593	Seriola_dumerili
ENSG00000144566	RAB5A	100	92.593	ENSSLDG00000011069	rab5aa	100	92.593	Seriola_lalandi_dorsalis
ENSG00000144566	RAB5A	94	91.379	ENSSPUG00000001173	RAB5A	96	97.861	Sphenodon_punctatus
ENSG00000144566	RAB5A	100	91.667	ENSSPAG00000015678	rab5aa	100	91.667	Stegastes_partitus
ENSG00000144566	RAB5A	100	97.674	ENSSSCG00000037653	RAB5A	100	97.674	Sus_scrofa
ENSG00000144566	RAB5A	100	95.814	ENSTGUG00000003236	RAB5A	100	95.814	Taeniopygia_guttata
ENSG00000144566	RAB5A	99	91.628	ENSTRUG00000024368	rab5aa	99	91.628	Takifugu_rubripes
ENSG00000144566	RAB5A	100	91.204	ENSTNIG00000009196	rab5aa	100	91.204	Tetraodon_nigroviridis
ENSG00000144566	RAB5A	100	99.070	ENSTTRG00000001374	RAB5A	100	99.070	Tursiops_truncatus
ENSG00000144566	RAB5A	100	93.013	ENSUAMG00000027471	RAB5A	99	97.268	Ursus_americanus
ENSG00000144566	RAB5A	100	99.070	ENSUMAG00000018295	RAB5A	100	99.070	Ursus_maritimus
ENSG00000144566	RAB5A	100	99.070	ENSVVUG00000000489	RAB5A	100	99.070	Vulpes_vulpes
ENSG00000144566	RAB5A	100	92.593	ENSXETG00000002305	rab5a	100	92.593	Xenopus_tropicalis
ENSG00000144566	RAB5A	99	93.488	ENSXCOG00000020121	rab5aa	99	93.488	Xiphophorus_couchianus
ENSG00000144566	RAB5A	99	93.953	ENSXMAG00000028889	rab5aa	99	93.953	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	-	IEA	Component
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	15378032.17562788.24891604.	IDA	Function
GO:0005515	protein binding	7957092.9697774.10491193.11870209.15016378.15328530.15377662.15378032.16034420.16525121.16902405.17562788.17581628.21300063.21378754.22431521.23182941.23382462.24891604.25107275.26005850.29568061.	IPI	Function
GO:0005525	GTP binding	15378032.	IDA	Function
GO:0005737	cytoplasm	18034774.21266579.	IDA	Component
GO:0005768	endosome	21873635.	IBA	Component
GO:0005768	endosome	-	ISS	Component
GO:0005769	early endosome	21873635.	IBA	Component
GO:0005769	early endosome	15078902.15378032.17562788.18767904.21645192.24334765.25869668.	IDA	Component
GO:0005829	cytosol	23382462.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	Process
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006897	endocytosis	21873635.	IBA	Process
GO:0006897	endocytosis	15378032.	IDA	Process
GO:0006909	phagocytosis	-	IEA	Process
GO:0007596	blood coagulation	-	TAS	Process
GO:0008021	synaptic vesicle	21873635.	IBA	Component
GO:0008021	synaptic vesicle	-	ISS	Component
GO:0010008	endosome membrane	15016378.22431521.	IDA	Component
GO:0010008	endosome membrane	-	TAS	Component
GO:0015629	actin cytoskeleton	-	IEA	Component
GO:0019003	GDP binding	15378032.23382462.	IDA	Function
GO:0030100	regulation of endocytosis	21873635.	IBA	Process
GO:0030139	endocytic vesicle	21873635.	IBA	Component
GO:0030424	axon	21873635.	IBA	Component
GO:0030424	axon	-	ISS	Component
GO:0030425	dendrite	21873635.	IBA	Component
GO:0030425	dendrite	-	ISS	Component
GO:0030665	clathrin-coated vesicle membrane	-	TAS	Component
GO:0030670	phagocytic vesicle membrane	-	IEA	Component
GO:0031901	early endosome membrane	-	TAS	Component
GO:0032009	early phagosome	-	ISS	Component
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0036465	synaptic vesicle recycling	16141272.	IDA	Process
GO:0036477	somatodendritic compartment	16141272.	IDA	Component
GO:0039694	viral RNA genome replication	19376974.	IMP	Process
GO:0042470	melanosome	-	IEA	Component
GO:0043025	neuronal cell body	-	ISS	Component
GO:0043195	terminal bouton	16141272.	IDA	Component
GO:0043679	axon terminus	-	ISS	Component
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045022	early endosome to late endosome transport	17562788.	IMP	Process
GO:0045121	membrane raft	-	IEA	Component
GO:0045335	phagocytic vesicle	-	ISS	Component
GO:0045921	positive regulation of exocytosis	19966785.	IMP	Process
GO:0048169	regulation of long-term neuronal synaptic plasticity	21873635.	IBA	Process
GO:0051036	regulation of endosome size	17562788.	IMP	Process
GO:0051489	regulation of filopodium assembly	21873635.	IBA	Process
GO:0051489	regulation of filopodium assembly	14978216.	IDA	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0098559	cytoplasmic side of early endosome membrane	23382462.	IMP	Component
GO:0098842	postsynaptic early endosome	21873635.	IBA	Component
GO:0098993	anchored component of synaptic vesicle membrane	21873635.	IBA	Component
GO:0150093	amyloid-beta clearance by transcytosis	26005850.	IGI	Process
GO:2000286	receptor internalization involved in canonical Wnt signaling pathway	16890161.	IMP	Process
GO:2000300	regulation of synaptic vesicle exocytosis	16141272.	IMP	Process
GO:2000785	regulation of autophagosome assembly	24440914.	TAS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

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GWAS

PPI

Ortholog

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.