EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28212901	The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex (CubipyOXA) leads to cell death in NCI-H292 cancer cells.	J Inorg Biochem	2017 May	Caruso Bavisotto C	doi: 10.1016/j.jinorgbio.2017.02.004
12686536	Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages.	J Biol Chem	2003 Jun 20	Gao B	-
18790094	cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.	Biochim Biophys Acta	2008 Dec	Russo A	doi: 10.1016/j.bbagrm.2008.08.006
21642380	Molecular chaperones as a common set of proteins that regulate the invasion phenotype of head and neck cancer.	Clin Cancer Res	2011 Jul 15	Chiu CC	doi: 10.1158/1078-0432.CCR-10-2107
14634555	Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.	Am J Obstet Gynecol	2003 Nov	Paavonen J	-
26810190	The tumor promoting roles of HSP60 and HIF2α in gastric cancer cells.	Tumour Biol	2016 Jul	Tong WW	doi: 10.1007/s13277-015-4783-2
26060090	Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.	Cancer	2015 Sep 15	Campanella C	doi: 10.1002/cncr.29499
27491302	Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.	Cell Stress Chaperones	2016 Sep	Rappa F	doi: 10.1007/s12192-016-0721-5
19369584	Interaction between HSP60 and beta-catenin promotes metastasis.	Carcinogenesis	2009 Jun	Tsai YP	doi: 10.1093/carcin/bgp087
19568603	Expression of heat shock protein 60 kDa is upregulated in cervical cancer.	Yonsei Med J	2009 Jun 30	Hwang YJ	doi: 10.3349/ymj.2009.50.3.399
20708221	Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer.	Urology	2010 Oct	Castilla C	doi: 10.1016/j.urology.2010.05.045
19635199	[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics].	Ai Zheng	2009 Jun	Zhang WL	-
19132982	Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer.	APMIS	2008 Oct	Glaessgen A	doi: 10.1111/j.1600-0463.2008.01051.x.
16705742	Proteomic comparison of prostate cancer cell lines LNCaP-FGC and LNCaP-r reveals heatshock protein 60 as a marker for prostate malignancy.	Prostate	2006 Sep 1	Johansson B	-
25207654	Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.	PLoS One	2014 Sep 10	Li XS	doi: 10.1371/journal.pone.0107507
23429486	HSP60 predicts survival in advanced serous ovarian cancer.	Int J Gynecol Cancer	2013 Mar	Hjerpe E	doi: 10.1097/IGC.0b013e318284308b.
24618330	Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer.	J Ovarian Res	2014 Mar 11	Bodzek P	doi: 10.1186/1757-2215-7-30.
20082317	Quantitative proteome analysis of multidrug resistance in human ovarian cancer cell line.	J Cell Biochem	2010 Mar 1	Li SL	doi: 10.1002/jcb.22413.
28347227	Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.	Tumour Biol	2017 Mar	Cai Q	doi: 10.1177/1010428317695015.
28591216	Modification effects of genetic polymorphisms in FTO, IL-6, and HSPD1 on the associations of diabetes with breast cancer risk and survival.	PLoS One	2017 Jun 7	Zhu RM	doi: 10.1371/journal.pone.0178850
30337218	Heat shock proteins 60 and 70 are associated with long-term outcome of T1-stage high-grade urothelial tumors of the bladder treated with intravesical Bacillus Calmette-Gu??rin immunotherapy.	Urol Oncol	2018 Dec	Mano R	doi: 10.1016/j.urolonc.2018.09.007

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	197494722	Missense_Mutation	novel	E181Q	0.08
BLCA	chr2	197493472	Missense_Mutation	NA	D241Y	0.26
BLCA	chr2	197489217	Missense_Mutation	NA	L334F	0.34
BLCA	chr2	197494722	Missense_Mutation	novel	E181Q	0.22
BLCA	chr2	197493329	Missense_Mutation	NA	L288F	0.06
BRCA	chr2	197497177	Missense_Mutation	novel	K130N	0.22
BRCA	chr2	197493455	Silent	NA	L246L	0.31
BRCA	chr2	197493364	Missense_Mutation	NA	D277N	0.16
BRCA	chr2	197489133	Missense_Mutation	NA	G362C	0.11
BRCA	chr2	197487140	Frame_Shift_Del	novel	*T540Kfs3**	0.4
BRCA	chr2	197498812	Frame_Shift_Ins	NA	*P13Tfs53**	0.31
BRCA	chr2	197487944	Missense_Mutation	NA	M495L	0.18
BRCA	chr2	197495344	Missense_Mutation	NA	E154K	0.13
COAD	chr2	197494746	Missense_Mutation	novel	T173A	0.28
COAD	chr2	197494657	Missense_Mutation	novel	K202N	0.35
COAD	chr2	197495230	Intron	novel		0.35
COAD	chr2	197495230	Intron	novel		0.22
COAD	chr2	197489039	Missense_Mutation	rs751104797	R393Q	0.47
COAD	chr2	197493429	Missense_Mutation	novel	Q255R	0.37
COAD	chr2	197497261	Silent	novel	A102A	0.31
COAD	chr2	197489056	Silent	novel	K387K	0.25
COAD	chr2	197488385	Frame_Shift_Del	NA	*G441Vfs14**	0.04
COAD	chr2	197489109	Missense_Mutation	rs768557320	R370C	0.11
COAD	chr2	197498734	Missense_Mutation	NA	L39V	0.13
COAD	chr2	197487013	3'UTR	novel		0.33
GBM	chr2	197488385	Missense_Mutation	novel	G441D	0.11
GBM	chr2	197489217	Missense_Mutation	novel	L334I	0.57
GBM	chr2	197487950	Nonsense_Mutation	novel	K493*	0.11
GBM	chr2	197498689	Missense_Mutation	novel	T54A	0.25
HNSC	chr2	197486920	3'UTR	novel		0.32
HNSC	chr2	197496992	Intron	novel		0.38
HNSC	chr2	197498739	Missense_Mutation	NA	R37Q	0.17
HNSC	chr2	197489008	Frame_Shift_Del	novel	L404*	0.3
KICH	chr2	197493393	Missense_Mutation	novel	H267L	0.41
KIRC	chr2	197497352	Missense_Mutation	NA	K72T	0.27
KIRP	chr2	197497383	Frame_Shift_Del	novel	*V62Dfs3**	0.34
LGG	chr2	197488447	Frame_Shift_Del	novel	*D419Efs35**	0.43
LGG	chr2	197494196	Nonsense_Mutation	novel	R221*	0.34
LIHC	chr2	197489193	Missense_Mutation	novel	L342V	0.42
LIHC	chr2	197493349	Missense_Mutation	novel	A282P	0.29
LUAD	chr2	197493427	Missense_Mutation	novel	S256T	0.24
LUSC	chr2	197487062	Missense_Mutation	novel	G569V	0.12
LUSC	chr2	197497197	Missense_Mutation	NA	A124P	0.33
LUSC	chr2	197488341	Missense_Mutation	novel	P456S	0.28
LUSC	chr2	197494226	Silent	NA	L211L	0.12
OV	chr2	197498675	Missense_Mutation	NA	K58N	0.29
PAAD	chr2	197497186	Silent	novel	G127G	0.17
PAAD	chr2	197498735	Silent	novel	A38A	0.03
PAAD	chr2	197498845	Missense_Mutation	novel	L2F	0.16
PRAD	chr2	197495230	Intron	novel		0.44
PRAD	chr2	197488474	Silent	NA	D411D	0.06
PRAD	chr2	197489109	Missense_Mutation	rs768557320	R370C	0.45
READ	chr2	197489157	Missense_Mutation	NA	D354N	0.21
READ	chr2	197497297	Nonsense_Mutation	NA	Y90*	0.18
READ	chr2	197497073	Intron	novel		0.07
READ	chr2	197488371	Nonsense_Mutation	NA	R446*	0.44
READ	chr2	197497087	Intron	novel		0.38
SARC	chr2	197488422	Frame_Shift_Del	novel	*R429Efs26**	0.2
SARC	chr2	197493399	Missense_Mutation	rs149003485	N265S	0.18
SKCM	chr2	197489047	Silent	novel	L390L	0.21
SKCM	chr2	197487174	Missense_Mutation	novel	A532S	0.32
SKCM	chr2	197489009	Missense_Mutation	NA	V403G	0.34
SKCM	chr2	197490288	Missense_Mutation	NA	V293A	0.27
SKCM	chr2	197493401	Silent	novel	A264A	0.41
SKCM	chr2	197498739	Missense_Mutation	NA	R37Q	0.05
STAD	chr2	197495230	Intron	novel		0.67
STAD	chr2	197487056	In_Frame_Del	novel	M568_G571del	0.12
STAD	chr2	197489074	Silent	NA	T381T	0.25
STAD	chr2	197495230	Intron	novel		0.71
STAD	chr2	197495273	Intron	novel		0.29
STAD	chr2	197497281	Missense_Mutation	NA	K96E	0.13
STAD	chr2	197487193	Silent	novel	V525V	0.15
STAD	chr2	197495294	Missense_Mutation	novel	Q170H	0.14
STAD	chr2	197487068	In_Frame_Del	novel	G567_G570del	0.25
STAD	chr2	197487917	Missense_Mutation	NA	D504N	0.14
STAD	chr2	197489140	Frame_Shift_Del	novel	*G360Efs19**	0.35
STAD	chr2	197495230	Intron	novel		1
THCA	chr2	197487065	Missense_Mutation	rs751438836	M568T	0.14
THCA	chr2	197493489	Frame_Shift_Ins	novel	*Q235Lfs15**	0.05
UCEC	chr2	197495230	Intron	novel		0.27
UCEC	chr2	197488371	Nonsense_Mutation	NA	R446*	0.3
UCEC	chr2	197497183	Silent	rs762474761	F128F	0.1
UCEC	chr2	197489109	Missense_Mutation	rs768557320	R370C	0.39
UCEC	chr2	197486862	3'UTR	novel		0.27
UCEC	chr2	197488415	Missense_Mutation	novel	A431D	0.4
UCEC	chr2	197495177	Intron	novel		0.57
UCEC	chr2	197497117	Intron	novel		0.2
UCEC	chr2	197497158	Missense_Mutation	novel	P137S	0.19
UCEC	chr2	197486910	3'UTR	novel		0.38
UCEC	chr2	197495230	Intron	novel		0.58
UCEC	chr2	197497182	Missense_Mutation	rs139436185	E129K	0.33
UCEC	chr2	197495256	Intron	novel		0.33
UCEC	chr2	197488340	Missense_Mutation	novel	P456L	0.35
UCEC	chr2	197497099	Intron	novel		0.32
UCEC	chr2	197490236	Missense_Mutation	novel	K310N	0.22
UCEC	chr2	197497104	Intron	novel		0.51
UCEC	chr2	197486966	3'UTR	novel		0.35
UCEC	chr2	197495230	Intron	novel		0.54
UCEC	chr2	197495230	Intron	novel		0.48
UCEC	chr2	197497182	Missense_Mutation	rs139436185	E129K	0.38
UCEC	chr2	197486861	3'UTR	novel		0.27
UCEC	chr2	197488320	Frame_Shift_Del	novel	*I463Lfs3**	0.37
UCEC	chr2	197486870	3'UTR	novel		0.27
UCEC	chr2	197497013	Intron	novel		0.21
UCEC	chr2	197495230	Intron	novel		0.82
UCEC	chr2	197495230	Intron	novel		0.26
UCEC	chr2	197489209	Silent	rs780050389	D336D	0.13
UCEC	chr2	197497192	Missense_Mutation	NA	K125N	0.33
UCEC	chr2	197496921	Intron	novel		0.64
UCEC	chr2	197494722	Nonsense_Mutation	NA	E181*	0.3
UCEC	chr2	197487122	Missense_Mutation	NA	I549S	0.44
UCEC	chr2	197489209	Silent	rs780050389	D336D	0.41
UCEC	chr2	197497024	Intron	novel		0.26
UCEC	chr2	197494197	Silent	novel	D220D	0.33
UCEC	chr2	197489109	Missense_Mutation	rs768557320	R370C	0.32
UCEC	chr2	197495230	Intron	novel		0.3
UCEC	chr2	197486816	3'UTR	novel		0.29
UCS	chr2	197494686	Frame_Shift_Ins	novel	*V193Sfs17**	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1424	0.012962
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.0272	0.2014

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0051	Kaplan-Meier Survival Analysis
MESO	0.027	Kaplan-Meier Survival Analysis
ACC	0.0011	Kaplan-Meier Survival Analysis
HNSC	0.01	Kaplan-Meier Survival Analysis
LUSC	0.03	Kaplan-Meier Survival Analysis
BRCA	0.05	Kaplan-Meier Survival Analysis
ESCA	0.0026	Kaplan-Meier Survival Analysis
KIRP	0.00032	Kaplan-Meier Survival Analysis
PAAD	0.014	Kaplan-Meier Survival Analysis
KICH	0.029	Kaplan-Meier Survival Analysis
UCEC	0.00014	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
THCA	0.038	Kaplan-Meier Survival Analysis
LUAD	0.00067	Kaplan-Meier Survival Analysis
OV	0.0098	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000144381 (Gene tree)
Gene ID: 3329
Gene Symbol: HSPD1
Alias: GroEL|HSP60|SPG13
Full Name: heat shock protein family D (Hsp60) member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 30,157 bases
Position: chr2:197,486,581-197,516,737
Accession: 5261
RBP type: non-canonical RBP
Summary: This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19940440	Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator.	Sex Dev	2010	Kohno S	doi: 10.1159/000260374
12093179	Binding site analysis of human HBV pol for molecular chaperonin, hsp60.	Virology	2002 Jun 20	Park SG	-
8728645	Circular assemblies.	Curr Opin Struct Biol	1996 Apr	Antson AA	-
16872603	Chloroplast heat shock protein Cpn60 from Chlamydomonas reinhardtii exhibits a novel function as a group II intron-specific RNA-binding protein.	FEBS Lett	2006 Aug 7	Balczun C	-
15563614	Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content.	Plant Physiol	2004 Dec	Sjogren LL	-
27158334	The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression.	Am J Transl Res	2016 Feb 15	Huang CY	-
10591847	Identification of salt-regulated genes in the genome of the cyanobacterium Synechocystis sp. strain PCC 6803 by subtractive RNA hybridization.	Arch Microbiol	1999 Dec	Vinnemeier J	-
15479789	Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis.	J Virol	2004 Nov	Brasier AR	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430176	HSPD1-206	754	-	ENSP00000393670	234 (aa)	-	E7ESH4
ENST00000476746	HSPD1-211	853	-	-	- (aa)	-	-
ENST00000439605	HSPD1-207	578	-	ENSP00000402478	83 (aa)	-	C9JL19
ENST00000428204	HSPD1-205	549	-	ENSP00000396460	94 (aa)	-	C9JCQ4
ENST00000440114	HSPD1-208	619	-	ENSP00000390404	48 (aa)	-	F8WBB1
ENST00000452200	HSPD1-209	888	-	ENSP00000412717	221 (aa)	-	E7EXB4
ENST00000426480	HSPD1-204	529	-	ENSP00000414446	175 (aa)	-	C9JL25
ENST00000486181	HSPD1-213	648	-	-	- (aa)	-	-
ENST00000491249	HSPD1-214	860	-	-	- (aa)	-	-
ENST00000482167	HSPD1-212	491	-	-	- (aa)	-	-
ENST00000388968	HSPD1-202	2455	-	ENSP00000373620	573 (aa)	-	P10809
ENST00000345042	HSPD1-201	2299	-	ENSP00000340019	573 (aa)	-	P10809
ENST00000461097	HSPD1-210	714	-	-	- (aa)	-	-
ENST00000418022	HSPD1-203	533	-	ENSP00000412227	58 (aa)	-	C9J0S9

Gene Model

Click here to download ENSG00000144381's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG
hsa04940	Type I diabetes mellitus	KEGG
hsa05134	Legionellosis	KEGG
hsa05152	Tuberculosis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000144381	rs58335266	2	197505616	G	Major depression and alcohol dependence	29071344	[0.19-0.49] unit increase	0.341	EFO_0003761\|EFO_0003829

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144381's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144381	HSPD1	100	98.643	ENSMUSG00000025980	Hspd1	100	98.592	Mus_musculus
ENSG00000144381	HSPD1	92	59.709	YLR259C	HSP60	94	56.852	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001530	lipopolysaccharide binding	17164250.	IDA	Function
GO:0002039	p53 binding	18086682.	IPI	Function
GO:0002368	B cell cytokine production	16148103.	IDA	Process
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	16148103.	IDA	Process
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	10663613.	IDA	Process
GO:0003688	DNA replication origin binding	-	ISS	Function
GO:0003697	single-stranded DNA binding	-	ISS	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0005515	protein binding	15846844.17823127.18086682.21516116.21988832.23349634.23840630.24286120.25416956.25910212.26871637.29568061.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005615	extracellular space	18229457.	IDA	Component
GO:0005737	cytoplasm	21328542.	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	17823127.18086682.21245038.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	ISS	Component
GO:0005759	mitochondrial matrix	19393246.24746669.	IDA	Component
GO:0005759	mitochondrial matrix	17823127.	TAS	Component
GO:0005769	early endosome	11807771.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	17823127.18086682.	IDA	Component
GO:0005886	plasma membrane	11027668.	IDA	Component
GO:0005905	clathrin-coated pit	11807771.	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0006458	'de novo' protein folding	21873635.	IBA	Process
GO:0006458	'de novo' protein folding	-	ISS	Process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	17823127.	IDA	Process
GO:0006986	response to unfolded protein	11050098.	IDA	Process
GO:0007005	mitochondrion organization	21873635.	IBA	Process
GO:0008035	high-density lipoprotein particle binding	11027668.	IDA	Function
GO:0008637	apoptotic mitochondrial changes	21873635.	IBA	Process
GO:0009409	response to cold	-	ISS	Process
GO:0009986	cell surface	9243807.10663613.11807771.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016887	ATPase activity	-	ISS	Function
GO:0019899	enzyme binding	20507888.	IPI	Function
GO:0030135	coated vesicle	11807771.	IDA	Component
GO:0030141	secretory granule	-	ISS	Component
GO:0031625	ubiquitin protein ligase binding	19725078.21753002.	IPI	Function
GO:0032727	positive regulation of interferon-alpha production	17164250.	IDA	Process
GO:0032729	positive regulation of interferon-gamma production	17164250.	IDA	Process
GO:0032729	positive regulation of interferon-gamma production	-	ISS	Process
GO:0032733	positive regulation of interleukin-10 production	16148103.	IDA	Process
GO:0032735	positive regulation of interleukin-12 production	17164250.	IDA	Process
GO:0032755	positive regulation of interleukin-6 production	16148103.	IDA	Process
GO:0032991	protein-containing complex	21328542.23349634.	IDA	Component
GO:0034185	apolipoprotein binding	11027668.	IPI	Function
GO:0034186	apolipoprotein A-I binding	11027668.	IPI	Function
GO:0042026	protein refolding	11050098.	IDA	Process
GO:0042100	B cell proliferation	16148103.	IDA	Process
GO:0042110	T cell activation	21873635.	IBA	Process
GO:0042110	T cell activation	15371451.17164250.18256040.	IDA	Process
GO:0042113	B cell activation	16148103.	IDA	Process
GO:0043032	positive regulation of macrophage activation	17164250.	IDA	Process
GO:0043065	positive regulation of apoptotic process	17823127.	IMP	Process
GO:0043066	negative regulation of apoptotic process	17823127.18086682.	IMP	Process
GO:0044406	adhesion of symbiont to host	20633027.	IDA	Process
GO:0045041	protein import into mitochondrial intermembrane space	21873635.	IBA	Process
GO:0046696	lipopolysaccharide receptor complex	17164250.	IDA	Component
GO:0048291	isotype switching to IgG isotypes	16148103.	IDA	Process
GO:0050821	protein stabilization	18086682.	IMP	Process
GO:0050821	protein stabilization	-	ISS	Process
GO:0050870	positive regulation of T cell activation	16148103.17164250.	IDA	Process
GO:0050870	positive regulation of T cell activation	-	ISS	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051082	unfolded protein binding	11050098.	IC	Function
GO:0051082	unfolded protein binding	-	ISS	Function
GO:0051087	chaperone binding	10205158.	IPI	Function
GO:0051131	chaperone-mediated protein complex assembly	-	ISS	Process
GO:0051604	protein maturation	-	ISS	Process
GO:0051702	interaction with symbiont	20507888.	IMP	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component
GO:0070062	extracellular exosome	21276792.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.