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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23275151PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.Carcinogenesis2013 AprCheng Hdoi: 10.1093/carcin/bgs393
22993403Dual roles of PARP-1 promote cancer growth and progression.Cancer Discov2012 DecSchiewer MJdoi: 10.1158/2159-8290.CD-12-0120
21612407Lymph node metastasis of gastric cancer is associated with the interaction between poly (ADP-ribose) polymerase 1 and matrix metallopeptidase 2.DNA Cell Biol2011 DecKim Jdoi: 10.1089/dna.2011.1250
24939750Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription.Oncotarget2014 Nov 15Ciccarone F-
28167507PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.Clin Cancer Res2017 Jul 15Jiao Sdoi: 10.1158/1078-0432.CCR-16-3215
29684820Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.Redox Biol2018 JulHou Ddoi: 10.1016/j.redox.2018.03.016
26920250Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer.Biochem Pharmacol2016 May 1Zhou Qdoi: 10.1016/j.bcp.2016.02.015
29632181PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.Proc Natl Acad Sci U S A2018 Apr 24Drsam Bdoi: 10.1073/pnas.1712345115
14557488Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma.J Clin Endocrinol Metab2003 OctHuang SC-
24535833Inherited variation in the PARP1 gene and survival from melanoma.Int J Cancer2014 Oct 1Davies JRdoi: 10.1002/ijc.28796
22472897PARP-1 protein expression in glioblastoma multiforme.Eur J Histochem2012 Feb 27Galia Adoi: 10.4081/ejh.2012.e9.
19655414The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.Am J Chin Med2009Li SL-
22864776Colorectal cancers differ in respect of PARP-1 protein expression.Pol J Pathol2012 JunSulzyc-Bielicka V-
25257171Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation.Cell Death Differ2015 FebKumari Adoi: 10.1038/cdd.2014.146
22392482Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ.Apoptosis2012 JulWarrener Pdoi: 10.1007/s10495-012-0707-4.
18314489Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.Mol Cancer Res2008 FebElser Mdoi: 10.1158/1541-7786.MCR-07-0377.
19784808Doxorubicin-mediated apoptosis in glioma cells requires NFAT3.Cell Mol Life Sci2009 DecGopinath Sdoi: 10.1007/s00018-009-0157-5
15286704Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.Oncogene2004 Sep 23Veuger SJ-
20113831Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines.Cancer Genet Cytogenet2010 FebOgino Hdoi: 10.1016/j.cancergencyto.2009.10.012.
21555554Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.Proc Natl Acad Sci U S A2011 Jun 14Krawczyk PMdoi: 10.1073/pnas.1101053108
15564335The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species.Endocrinology2005 MarNewton CJ-
27440880Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1.J Virol2016 Sep 12Martin KAdoi: 10.1128/JVI.01180-16
27787517PARP1 regulates the protein stability and proapoptotic function of HIPK2.Cell Death Dis2016 Oct 27Choi JRdoi: 10.1038/cddis.2016.345.
28454547PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.Mol Cancer2017 Apr 28Pignochino Ydoi: 10.1186/s12943-017-0652-5.
25225750PARP-1 rs3219073 polymorphism may contribute to susceptibility to lung cancer.Genet Test Mol Biomarkers2014 NovWang HTdoi: 10.1089/gtmb.2014.0106
23254695Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADPribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells.Int J Oncol2013 FebFeng Xdoi: 10.3892/ijo.2012.1740
22166496The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.Carcinogenesis2012 MarTeo MTdoi: 10.1093/carcin/bgr300
24436031Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients.Int Urol Nephrol2014 JulWu Wdoi: 10.1007/s11255-014-0642-0
18716896PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population.Mol Biol Rep2009 JulZhang Qdoi: 10.1007/s11033-008-9336-y
22127734Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.Genet Epidemiol2012 JanYu Hdoi: 10.1002/gepi.20663
29393407PARP1-siRNA suppresses human prostate cancer cell growth and progression.Oncol Rep2018 AprLai Ydoi: 10.3892/or.2018.6238
24726141The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells.Neoplasia2014 MarPiao Ldoi: 10.1016/j.neo.2014.03.002
22221038PARP1 polymorphisms increase the risk of gastric cancer in a Chinese population.Mol Diagn Ther2012 Feb 1He Wdoi: 10.2165/11595630-000000000-00000.
25037599PARP-1 and CASP3 genes are up-regulated in LNCaP and PC-3 prostate cancer cell lines.Hum Cell2014 OctSalemi Mdoi: 10.1007/s13577-013-0076-5
20218899Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer.DNA Cell Biol2010 JunWang Mdoi: 10.1089/dna.2009.0969.
23244082XRCC1 and ADPRT polymorphisms associated with survival in breast cancer cases treated with chemotherapy.Asian Pac J Cancer Prev2012Ye S-
27871924MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1.Gene2017 Feb 5Luo Ydoi: 10.1016/j.gene.2016.11.031
23510475Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.Cell Prolif2013 AprLoganathan Rdoi: 10.1111/cpr.12014.
19109787Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology.Methods Mol Biol2009Jiang Jdoi: 10.1007/978-1-59745-416-2_16.
22660976The role of PARP1 in the DNA damage response and its application in tumor therapy.Front Med2012 JunWang Zdoi: 10.1007/s11684-012-0197-3
22384823High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer.Histopathology2012 SepKlauschen Fdoi: 10.1111/j.1365-2559.2012.04225.x
27466483Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein.Anticancer Res2016 AugTome Y-
25738796Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.Int J Mol Med2015 MayZheng Bdoi: 10.3892/ijmm.2015.2125
16328064Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis.Oncol Rep2006 JanZhai X-
20823142Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer.Clin Cancer Res2010 Sep 15Annunziata CMdoi: 10.1158/1078-0432.CCR-10-0526
23430444Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population.Med Oncol2013 JunLi Ydoi: 10.1007/s12032-013-0505-z
17560163Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.Mutat Res2007 Aug 15Cao WH-
24866151Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.Cancer Discov2014 AugGonz??lez-Billalabeitia Edoi: 10.1158/2159-8290.CD-13-0230
27055253Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.PLoS One2016 Apr 7Cardnell RJdoi: 10.1371/journal.pone.0152584
24448423Poly (ADP-ribose) polymerase 1 transcriptional regulation: a novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer.Oncotarget2014 Jan 15Li D-
23644255Effects of passive smoking on breast cancer risk in pre/post-menopausal women as modified by polymorphisms of PARP1 and ESR1.Gene2013 Jul 25Tang LYdoi: 10.1016/j.gene.2013.04.064
26826460Decreased DNA repair gene XRCC1 expression is associated with radiotherapy-induced acute side effects in breast cancer patients.Gene2016 May 10Batar Bdoi: 10.1016/j.gene.2016.01.040
23548269Germline mutations of BRCA1 gene exon 11 are not associated with platinum response neither with survival advantage in patients with primary ovarian cancer: understanding the clinical importance of one of the biggest human exons. A study of the Tumor Bank Ovarian Cancer (TOC) Consortium.Tumour Biol2016 SepDimitrova D-
25128455Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer.Eur J Cancer2014 OctGarc??a-Parra Jdoi: 10.1016/j.ejca.2014.07.004
25883215Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.Oncotarget2015 May 10Frankum J-
23633189Involvement of PARP-1 Val762Ala polymorphism in the onset of cervical cancer in caucasian women.Mol Diagn Ther2013 AugRoszak Adoi: 10.1007/s40291-013-0036-5.
26091341Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function.Mol Cell2015 Jun 18Feng FYdoi: 10.1016/j.molcel.2015.04.016.
21532888p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.Neoplasia2011 MayMeng F-
24535158Nuclear-cytoplasmic PARP-1 expression as an unfavorable prognostic marker in lymph nodenegative early breast cancer: 15-year follow-up.Oncol Rep2014 AprDonizy Pdoi: 10.3892/or.2014.3024
25480692The nuclear expression of poly (ADP-ribose) polymerase-1 (PARP1) in invasive primary breast tumors is associated with chemotherapy sensitivity.Pathol Res Pract2015 FebZhai Ldoi: 10.1016/j.prp.2014.11.004
26540566Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications.Oncotarget2015 Dec 29Park SHdoi: 10.18632/oncotarget.6264.
25400754Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer.Int J Clin Exp Pathol2014 Sep 15Kim HC-
19568233Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines.Br J Cancer2009 Jul 21Zaremba Tdoi: 10.1038/sj.bjc.6605166
25611238The prognostic and predictive significance of PARP-1 in locally advanced breast cancer of Egyptian patients receiving neoadjuvant chemotherapy.Appl Immunohistochem Mol Morphol2015 SepAiad HAdoi: 10.1097/PAI.0000000000000124.
28118040PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy.Cancer Biother Radiopharm2017 FebSander Effron Sdoi: 10.1089/cbr.2016.2133
25333575Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.Oncol Rep2014 DecJiang Xdoi: 10.3892/or.2014.3533
17943227Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer.J Hum Genet2007Durocher F-
25526641PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.PLoS One2014 Dec 19Dziaman Tdoi: 10.1371/journal.pone.0115558
20373286Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.EMBO Mol Med2010 AprSourisseau Tdoi: 10.1002/emmm.201000068.
21434873Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers.Biochem J2011 Jun 15Zaremba Tdoi: 10.1042/BJ20101723.
21037106Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.Cancer Epidemiol Biomarkers Prev2010 DecBrevik Adoi: 10.1158/1055-9965.EPI-10-0606
22134241Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.Cell Cycle2011 Dec 15Vance Sdoi: 10.4161/cc.10.24.18661
21908496Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer.Ann Oncol2012 MayRojo Fdoi: 10.1093/annonc/mdr361
17975135Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy.Clin Cancer Res2007 Nov 1Plummer ER-
26356822Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer.Oncotarget2015 Oct 13Brodie SAdoi: 10.18632/oncotarget.5040.
23479135Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer.Cancer Chemother Pharmacol2013 MayZhao Wdoi: 10.1007/s00280-013-2127-8
24870775Novel mutations of the PARP-1 gene associated with colorectal cancer in the Saudi population.Asian Pac J Cancer Prev2014Alshammari AH-
24489833Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.PLoS One2014 Jan 28Hua RXdoi: 10.1371/journal.pone.0087057
24761869Expression of ERCC1, MSH2 and PARP1 in non-small cell lung cancer and prognostic value in patients treated with platinum-based chemotherapy.Asian Pac J Cancer Prev2014Xie KJ-
25528020Biological and clinical significance of PARP1 protein expression in breast cancer.Breast Cancer Res Treat2015 JanGreen ARdoi: 10.1007/s10549-014-3230-1
26387143Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer.Ann Oncol2015 DecMichels Jdoi: 10.1093/annonc/mdv393
22982218The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines.Mol Cell Endocrinol2013 Jan 5Lavarone Edoi: 10.1016/j.mce.2012.08.019
27746584The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort.Dis Markers2016Alhadheq AM-
23317230Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study.Asian Pac J Cancer Prev2012Pan XF-
21575865Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.Cancer Cell2011 May 17Brenner JCdoi: 10.1016/j.ccr.2011.04.010.
22337872CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.J Biol Chem2012 Apr 13Kashima Ldoi: 10.1074/jbc.M111.321828
24853559PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.PLoS One2014 May 22Qin Qdoi: 10.1371/journal.pone.0098022
27323894Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients.Biomarkers2017 FebNogueira Adoi: 10.1080/1354750X.2016.1204006
24889936Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.J Pathol2014 OctMart??nez-Bosch Ndoi: 10.1002/path.4384
23803078The C allele of a synonymous SNP (rs1805414, Ala284Ala) in PARP1 is a risk factor for susceptibility to breast cancer in Saudi patients.Asian Pac J Cancer Prev2013Alanazi M-
23073772Racial and tissue-specific cancer risk associated with PARP1 (ADPRT) Val762Ala polymorphism: a meta-analysis.Mol Biol Rep2012 DecPabalan Ndoi: 10.1007/s11033-012-2009-x
24191908BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer.BMC Cancer2013 Nov 5Jacot Wdoi: 10.1186/1471-2407-13-523.
26900125Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent.Sci Rep2016 Feb 22Kossatz Sdoi: 10.1038/srep21371.
22983827Association between polymorphisms of XRCC1 and ADPRT genes and ovarian cancer survival with platinum-based chemotherapy in Chinese population.Mol Cell Biochem2013 JanLi Kdoi: 10.1007/s11010-012-1442-4
19513550gammaH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids.Int J Oncol2009 JulQvarnstrm OF-
27362900The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection.Int J Gynecol Pathol2017 MarHjortkjr Mdoi: 10.1097/PGP.0000000000000310.
28212434Prognostic and clinicopathological value of poly (adenosine diphosphate-ribose) polymerase expression in breast cancer: A meta-analysis.PLoS One2017 Feb 17Qiao Wdoi: 10.1371/journal.pone.0172413
27847302Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials.Cancer Lett2017 Feb 1Yuan Bdoi: 10.1016/j.canlet.2016.11.010
28302009Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement.Curr Med Chem2017Mart??n-Guerrero SMdoi: 10.2174/0929867324666170316115039.
28031413Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors.Mol Cancer Res2017 MarWielgos MEdoi: 10.1158/1541-7786.MCR-16-0287-T
28985359PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.Nucleic Acids Res2017 Oct 13Hsieh MHdoi: 10.1093/nar/gkx683.
29063620Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance.Prostate2017 DecStark TWdoi: 10.1002/pros.23435
28713983MalforminA1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway.Int J Oncol2017 SepPark SYdoi: 10.3892/ijo.2017.4070
28930534Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications.Front Biosci (Landmark Ed)2018 Jan 1Piao L-
29048575MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis.Mutagenesis2017 Oct 17Schneiderova Mdoi: 10.1093/mutage/gex026.
28802254TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.Mol Cancer Ther2017 NovAl Abo Mdoi: 10.1158/1535-7163.MCT-17-0110
30275188P-gp Inhibition by the Anti-psychotic Drug Pimozide Increases Apoptosis, as well as Expression of pRb and pH2AX in Highly Drug-resistant KBV20C Cells.Anticancer Res2018 OctKim JYdoi: 10.21873/anticanres.12905.
29973717CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.Nature2018 JulZimmermann Mdoi: 10.1038/s41586-018-0291-z
29950726High speed of fork progression induces DNA replication stress and genomic instability.Nature2018 JulMaya-Mendoza Adoi: 10.1038/s41586-018-0261-5
24970803Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells.Oncotarget2014 Jul 15Bridges KA-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1226385565Missense_MutationnovelA317V0.05
ACCchr1226367490Missense_MutationnovelT799I0.23
ACCchr1226379260Missense_Mutationrs200485374A543T0.22
BLCAchr1226377176Missense_Mutationrs577466994A625T0.25
BLCAchr1226379994Missense_MutationnovelE491K0.16
BLCAchr1226402253Nonsense_MutationnovelQ83*0.18
BLCAchr1226361508SilentnovelL999L0.44
BLCAchr12264080035'UTRnovel0.36
BLCAchr1226377194Missense_MutationnovelE619K0.6
BLCAchr1226366046Missense_MutationnovelD805N0.25
BLCAchr1226367590Missense_MutationNAD766N0.33
BLCAchr1226379209Missense_MutationNAV560L0.35
BLCAchr1226383103Silentrs761844848S364S0.18
BLCAchr1226388665Frame_Shift_DelnovelA237Pfs*20.13
BLCAchr1226364018Missense_MutationNAS904T0.51PARP
BLCAchr1226367590Missense_MutationNAD766N0.26
BLCAchr1226380165Splice_SiteNAX434_splice0.11
BLCAchr1226392940Intronnovel0.62
BRCAchr1226383034Splice_SiteNAX387_splice0.08
BRCAchr1226385597Silentrs755443483S306S0.16
BRCAchr1226402232Missense_MutationnovelE90K0.09
BRCAchr1226407828SilentnovelR34R0.11
BRCAchr1226374264Missense_MutationNAD678H0.12
BRCAchr1226385596Missense_Mutationrs377195931D307N0.08
BRCAchr1226379184Missense_MutationNAS568C0.56
BRCAchr1226407902Missense_MutationnovelR10G0.05
BRCAchr1226383089Missense_MutationNAP369L0.18
BRCAchr1226390478SilentnovelG183G0.05
BRCAchr12263614403'UTRnovel0.62
BRCAchr1226367488Missense_MutationNAD800N0.27
BRCAchr1226392289Missense_MutationNAS104R0.35
BRCAchr1226385596Missense_Mutationrs377195931D307N0.11
BRCAchr1226365136Missense_MutationnovelE842K0.1PARP
BRCAchr1226361534Missense_MutationnovelV991L0.07PARP
BRCAchr1226383093Missense_MutationnovelT368P0.31
BRCAchr1226377245Nonsense_MutationnovelE602*0.07
BRCAchr1226381159Silentrs776889972R403R0.15
CESCchr12264080035'UTRnovel0.27
CESCchr1226364135IntronNA0.18
CESCchr12264080035'UTRnovel0.14
CESCchr1226390456Missense_MutationNAD191H0.13
CESCchr1226365005Silentrs373903460P885P0.33
CESCchr1226374258Missense_MutationNAE680Q0.22
CESCchr12264080035'UTRnovel0.31
CESCchr12264079955'UTRnovel0.17
CESCchr1226402251SilentNAQ83Q0.3
COADchr1226364044SilentNAI895I0.41
COADchr1226365097Missense_MutationNAH855N0.39PARP
COADchr1226362076SilentNAG952G0.21
COADchr12264079485'UTRnovel0.26
COADchr1226367491Frame_Shift_DelnovelT799Lfs*410.39
COADchr1226377153Silentrs200966933T632T0.11
COADchr1226383118Frame_Shift_InsNAE360Rfs*290.22
COADchr1226402258Missense_MutationNAD81G0.24
COADchr1226365090Missense_Mutationrs190105316R857Q0.26PARP
COADchr1226377177Silentrs147221209N624N0.18
COADchr1226377277Missense_Mutationrs377397890R591H0.28
COADchr1226388728SilentNAG215G0.26
COADchr1226362013Silentrs759984608T973T0.1
COADchr1226383139Frame_Shift_DelnovelK352Nfs*290.12
COADchr1226379946Frame_Shift_DelNAS507Afs*170.17
COADchr1226379946Frame_Shift_DelNAS507Afs*170.39
COADchr1226392288Missense_MutationnovelK105E0.24
COADchr1226380076Silentrs564778763S463S0.38
COADchr1226363153SilentNAL932L0.13
COADchr1226388714Missense_Mutationrs139232092A220V0.22
COADchr1226377177Silentrs147221209N624N0.29
COADchr1226379581Missense_MutationNAP535H0.36
COADchr1226366028Missense_MutationNAA811T0.33PARP
COADchr1226362060Missense_Mutationrs779988758P958S0.08PARP
COADchr1226365074Silentrs767353446H862H0.25
COADchr1226379957Missense_MutationNAL503R0.1
ESCAchr1226383092Missense_Mutationrs749502012T368M0.04
ESCAchr1226388687Missense_MutationnovelD229V0.4
GBMchr1226392272Missense_MutationnovelL110Q0.03
GBMchr1226402317SilentnovelG61G0.06
GBMchr1226363950Nonsense_MutationnovelG927*0.12PARP
GBMchr1226390411Missense_MutationnovelG206R0.29
GBMchr1226379965SilentnovelG500G0.05
GBMchr1226365028Missense_Mutationrs746139482R878W0.57PARP
GBMchr1226370515Splice_Regionrs377495505I691I0.45
GBMchr1226374350Missense_MutationnovelE649G0.56
GBMchr1226377268Missense_Mutationrs776941221T594M0.1
GBMchr1226363144Missense_Mutationrs759579130A935T0.37PARP
HNSCchr1226380099Missense_MutationnovelE456Q0.29
HNSCchr1226390507Missense_MutationnovelP174T0.55
HNSCchr1226386339Missense_MutationnovelS274F0.24
HNSCchr1226380079SilentnovelV462V0.12
HNSCchr1226361517SilentnovelQ996Q0.87
KIRCchr1226364045Missense_MutationNAI895T0.24PARP
KIRCchr1226377266Missense_MutationNAV595L0.05
KIRCchr1226377144SilentNAP635P0.21
KIRPchr1226368296In_Frame_DelnovelS727del0.26
KIRPchr1226383116Missense_MutationNAE360V0.42
KIRPchr1226383108Missense_Mutationrs779486158A363T0.46
LGGchr1226365131Silentrs148631906G843G0.48
LGGchr1226366001Missense_MutationNAN820D0.13PARP
LIHCchr1226368317Missense_MutationnovelV720E0.3
LIHCchr12264079315'UTRnovel0.23
LIHCchr1226402305SilentNAR65R0.79
LIHCchr1226383147Missense_MutationnovelV350I0.13
LUADchr1226379228Missense_MutationnovelF553L0.13
LUADchr1226365993SilentnovelH822H0.12
LUADchr1226366049Missense_MutationNAV804F0.24
LUADchr1226388734SilentNAV213V0.06
LUADchr1226361482Missense_MutationNAN1008S0.29
LUADchr1226386373Nonsense_MutationnovelE263*0.35
LUSCchr1226368262SilentNAT738T0.42
LUSCchr1226377131Missense_MutationnovelP640S0.29
LUSCchr1226363130SilentNAS939S0.2
LUSCchr1226379931Missense_MutationnovelK512E0.15
LUSCchr1226368322Splice_SiteNAX719_splice0.43
LUSCchr12264079955'UTRnovel0.16
LUSCchr1226379964Missense_MutationNAA501T0.04
LUSCchr1226379934Missense_MutationNAV511I0.14
LUSCchr1226402215Splice_RegionnovelT95T0.36
LUSCchr12264080445'UTRnovel0.26
LUSCchr1226379971SilentNAK498K0.31
OVchr1226379996Frame_Shift_InsnovelV490Afs*20.06
OVchr1226379197Missense_MutationnovelK564E0.11
OVchr1226379219SilentNAT556T0.33
OVchr1226364034Missense_MutationNAD899N0.17PARP
OVchr1226364046Missense_MutationNAI895V0.22PARP
PAADchr1226366051Missense_MutationnovelV803A0.21
PAADchr1226379201Silentrs534105862I562I0.26
PAADchr1226385597Silentrs755443483S306S0.23
PAADchr1226402268Missense_Mutationrs770918209R78W0.15
PRADchr1226367554Missense_MutationNAL778F0.35
PRADchr1226383089Missense_MutationNAP369L0.25
PRADchr1226363999Silentrs756963125T910T0.22
READchr1226390494Missense_Mutationrs202057244A178V0.25
READchr1226377255Missense_MutationnovelS598R0.09
READchr1226386377SilentnovelL261L0.2
SARCchr12263611643'UTRrs1390523230.46
SARCchr12264080465'UTRnovel0.56
SKCMchr1226392944Intronnovel0.18
SKCMchr1226361470Missense_MutationNAS1012F0.15
SKCMchr1226377232Missense_MutationNAS606F0.26
SKCMchr1226383103Silentrs761844848S364S0.23
SKCMchr1226383071Missense_MutationnovelS375L0.27
SKCMchr1226367516Silentrs148234314I790I0.2
SKCMchr1226368273Missense_Mutationrs766670559R735C0.42
SKCMchr1226377156SilentNAF631F0.33
SKCMchr1226379184Missense_MutationNAS568F0.13
SKCMchr1226390430SilentNAL199L0.18
SKCMchr1226368310SilentnovelQ722Q0.4
SKCMchr1226385528Silentrs770845304N329N0.57
SKCMchr1226379264SilentNAH541H0.18
SKCMchr1226374321Missense_MutationNAP659S0.82
SKCMchr1226379209Missense_MutationNAV560M0.16
SKCMchr1226361484SilentNAF1007F0.83
SKCMchr1226388721Missense_MutationNAE218K0.1
SKCMchr1226365031Missense_MutationnovelL877F0.47PARP
SKCMchr1226377146Missense_MutationnovelP635S0.32
STADchr1226381103Missense_Mutationrs751338176T422M0.1
STADchr1226379946Frame_Shift_DelNAS507Afs*170.22
STADchr12264079825'UTRnovel0.2
STADchr1226368261Frame_Shift_DelnovelL739*0.17
STADchr1226374329Missense_MutationNAT656I0.36
STADchr1226385597Silentrs755443483S306S0.39
STADchr1226383139Frame_Shift_DelnovelK352Nfs*290.3
STADchr1226379212Missense_MutationNAL559M0.21
STADchr1226383102Missense_Mutationrs774530658V365M0.19
STADchr1226365131Silentrs148631906G843G0.51
STADchr1226381174Silentrs373462891L398L0.51
STADchr1226363139SilentNAS936S0.1
STADchr1226381139Missense_MutationNAA410V0.34
STADchr1226381109Missense_Mutationrs757100394T420M0.15
STADchr1226366037Missense_MutationNAS808T0.07PARP
STADchr1226374297Missense_MutationnovelK667E0.33
STADchr1226379924Missense_MutationNAE514G0.25
STADchr1226368250Silentrs761046396H742H0.15
STADchr12263614353'UTRnovel0.35
STADchr1226377278Missense_Mutationrs752905479R591C0.32
STADchr1226365121Missense_Mutationrs750773674R847C0.21PARP
STADchr1226388743Silentrs372233336G210G0.3
UCECchr1226380046Missense_MutationNAF473L0.33
UCECchr12263613213'UTRnovel0.25
UCECchr1226364038Silentrs758785140F897F0.27
UCECchr1226361465Missense_MutationnovelW1014G0.28
UCECchr1226363971SilentnovelL920L0.28
UCECchr1226365070Missense_MutationnovelS864P0.15PARP
UCECchr1226365976Missense_Mutationrs147825810A828V0.36PARP
UCECchr1226367487Missense_MutationnovelD800G0.38
UCECchr1226368272Missense_Mutationrs780595440R735H0.31
UCECchr12263614053'UTRnovel0.61
UCECchr1226364026SilentnovelV901V0.14
UCECchr1226402338Missense_MutationnovelF54L0.33
UCECchr12263612553'UTRnovel0.5
UCECchr12263613713'UTRnovel0.09
UCECchr1226362031SilentNAV967V0.45
UCECchr1226362077Missense_MutationnovelG952D0.4PARP
UCECchr1226365085Missense_MutationnovelL859V0.34PARP
UCECchr12263613213'UTRnovel0.35
UCECchr1226365956Missense_MutationNAD835N0.13PARP
UCECchr12263612253'UTRnovel0.11
UCECchr1226380082Silentrs369942072D461D0.2
UCECchr1226377161Missense_MutationNAN630H0.37
UCECchr1226377278Missense_MutationNAR591S0.31
UCECchr1226381123Silentrs61731503L415L0.28
UCECchr1226386327Missense_Mutationrs201777393A278V0.27
UCECchr1226377176Missense_Mutationrs577466994A625T0.16
UCECchr1226364038Silentrs758785140F897F0.31
UCECchr1226379156Silentrs753320007D577D0.51
UCECchr1226379616Missense_MutationnovelM523I0.41
UCECchr1226381109Missense_Mutationrs757100394T420M0.3
UCECchr1226380018Frame_Shift_DelNAA483Qfs*30.18
UCECchr1226365139Missense_Mutationrs376334288R841C0.23PARP
UCECchr1226380041Missense_MutationnovelA475V0.36
UCECchr1226385630Silentrs745779414C295C0.26
UCECchr1226407919Missense_MutationnovelS4Y0.32
UCECchr1226374282Missense_MutationnovelL672I0.43
UCECchr1226390615Missense_Mutationrs193238922R138C0.3
UCECchr1226367516Silentrs148234314I790I0.51
UCECchr1226383118Frame_Shift_InsNAE360Rfs*290.36
UCECchr1226377133Missense_MutationNAY639C0.25
UCECchr1226377160Missense_MutationnovelN630T0.45
UCECchr12263611463'UTRnovel0.48
UCECchr1226385630Silentrs745779414C295C0.22
UCECchr1226379265Missense_MutationnovelH541R0.28
UCECchr1226381125Missense_MutationnovelL415F0.19
UCECchr1226383169SilentnovelI342I0.18
UCECchr1226370463Missense_Mutationrs758506201A709T0.37
UCECchr1226368320Missense_Mutationrs759524114A719V0.21
UCECchr1226379945Frame_Shift_InsnovelS507Kfs*140.33
UCECchr1226402278Missense_Mutationrs759516960F74L0.51
UCECchr1226379187Missense_Mutationrs201570154N567S0.07
UCECchr12263611553'UTRnovel0.24
UCECchr1226362029Missense_Mutationrs199689226D968G0.47PARP
UCECchr12263610303'UTRnovel0.15
UCECchr1226377278Missense_Mutationrs752905479R591C0.21
UCECchr1226385597Silentrs755443483S306S0.09
UCECchr1226379945Frame_Shift_InsnovelS507Kfs*140.41
UCECchr1226361468SilentNAL1013L0.19
UCECchr1226380152Frame_Shift_DelnovelK438Rfs*20.29
UCECchr1226402264Missense_MutationNAW79L0.24
UCECchr1226368226Silentrs200978353P750P0.45
UCECchr1226402378Missense_Mutationrs768342881S41L0.27
UCECchr1226365125SilentnovelC845C0.38
UCECchr1226365975Silentrs140555704A828A0.62
UCECchr1226385619Missense_Mutationrs374381502S299L0.39
UCECchr1226388670Nonsense_MutationnovelE235*0.39
UCECchr1226385618SilentNAS299S0.15

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.0760.033566
DLBCDEL0.14580.0017831
GBMDEL0.05030.00056261
KIRCDEL0.06440.018371
LGGDEL0.03120.11599
PCPGDEL0.08020.12617
PRADDEL0.06910.00015401
READAMP0.25450.14328
SARCDEL0.29572.6086e-08
TGCTDEL0.03330.16985
THYMAMP0.17890.24554
UCECAMP0.37852.3921e-06

Survival Analysis
CancerP-value Q-value
STAD0.0069

Kaplan-Meier Survival Analysis

MESO0.0023

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

SKCM0.002

Kaplan-Meier Survival Analysis

KIRP0.00018

Kaplan-Meier Survival Analysis

LAML0.0007

Kaplan-Meier Survival Analysis

KICH0.00024

Kaplan-Meier Survival Analysis

LIHC0.0015

Kaplan-Meier Survival Analysis

UVM0.025

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000143799 (Gene tree)
Gene ID
142
Gene Symbol
PARP1
Alias
PARP|PPOL|ADPRT
Full Name
poly(ADP-ribose) polymerase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
47,410 bases
Position
chr1:226,360,691-226,408,100
Accession
270
RBP type
canonical RBP
Summary
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000355759PARPPF00644.209.2e-7311
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
29432179PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability.Proc Natl Acad Sci U S A2018 Feb 20Chen JKdoi: 10.1073/pnas.1713912115
29949139STEEL participates in fracture healing through upregulating angiogenesis-related genes by recruiting PARP 1.Eur Rev Med Pharmacol Sci2018 JunZhang SZdoi: 10.26355/eurrev_201806_15245.
29387452Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis.Cell Discov2017 Nov 28Melikishvili Mdoi: 10.1038/celldisc.2017.43
24335297Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication.J Virol2014 FebAtasheva Sdoi: 10.1128/JVI.03443-13
22941645PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks.Nucleic Acids Res2012 Nov 1Krietsch Jdoi: 10.1093/nar/gks798
21846828Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.MBio2011 Aug 16Bortz Edoi: 10.1128/mBio.00151-11
26927092Roles of RNA-Binding Proteins in DNA Damage Response.Int J Mol Sci2016 Feb 27Kai Mdoi: 10.3390/ijms17030310.
30777121Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing.Epigenetics Chromatin2019 Feb 18Matveeva EAdoi: 10.1186/s13072-019-0261-1.
17785446The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription.Mol Cell Biol2007 NovWacker DA-
9122182Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro.Proc Natl Acad Sci U S A1997 Mar 18Meisterernst M-
16464859Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene.J Biol Chem2006 Apr 7Yu Z-
16115861Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.J Biol Chem2005 Oct 21Tapodi A-
15498776Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complex.J Biol Chem2005 Jan 7Parent M-
15302869Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells.J Biol Chem2004 Oct 8Nakajima H-
14715657Camptothecin-sensitive relaxation of supercoiled DNA by the topoisomerase I-like activity associated with poly(ADP-ribose) polymerase-1.J Biol Chem2004 Mar 19Yung TM-
18258916Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.Science2008 Feb 8Krishnakumar Rdoi: 10.1126/science.1149250.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000490921PARP1-2073165--- (aa)--
ENST00000491816PARP1-208416--- (aa)--
ENST00000366792PARP1-202553-ENSP00000355757108 (aa)-Q5VX84
ENST00000366790PARP1-201570-ENSP00000355755155 (aa)-Q5VX85
ENST00000498787PARP1-209628--- (aa)--
ENST00000463968PARP1-204830--- (aa)--
ENST00000629232PARP1-210477-ENSP00000485852108 (aa)-Q5VX84
ENST00000366794PARP1-2033958-ENSP000003557591014 (aa)-P09874
ENST00000469663PARP1-206542--- (aa)--
ENST00000468608PARP1-205438--- (aa)--
Gene Model
Click here to download ENSG00000143799's gene model file
Pathways
Pathway IDPathway NameSource
hsa03410Base excision repairKEGG
hsa04064NF-kappa B signaling pathwayKEGG
hsa04210ApoptosisKEGG
hsa04217NecroptosisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000143799Melanoma9E-821983785
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000143799rs7523071226363828?Platelet count29403010[0.016-0.033] unit increase novel0.02424EFO_0004309
ENSG00000143799rs32190901226376990CMelanoma21983785[NR]1.15EFO_0000756
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143799's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000143799PARP110070.381ENSAPOG00000006414parp110070.479Acanthochromis_polyacanthus
ENSG00000143799PARP19992.661ENSAMEG00000014451PARP110092.661Ailuropoda_melanoleuca
ENSG00000143799PARP110069.765ENSACIG00000005651parp110069.540Amphilophus_citrinellus
ENSG00000143799PARP110071.065ENSAOCG00000021005parp110071.065Amphiprion_ocellaris
ENSG00000143799PARP110071.163ENSAPEG00000004784parp110071.163Amphiprion_percula
ENSG00000143799PARP19970.993ENSATEG00000010457parp19970.993Anabas_testudineus
ENSG00000143799PARP18780.363ENSAPLG00000014039PARP110080.363Anas_platyrhynchos
ENSG00000143799PARP110076.824ENSACAG00000006189PARP110077.120Anolis_carolinensis
ENSG00000143799PARP110097.041ENSANAG00000032699PARP110097.041Aotus_nancymaae
ENSG00000143799PARP110071.386ENSACLG00000015489parp110071.386Astatotilapia_calliptera
ENSG00000143799PARP110069.366ENSAMXG00000006465parp110069.620Astyanax_mexicanus
ENSG00000143799PARP110090.757ENSBTAG00000000837PARP110090.757Bos_taurus
ENSG00000143799PARP19138.835WBGene00004049parp-110045.594Caenorhabditis_elegans
ENSG00000143799PARP110097.140ENSCJAG00000012831PARP110097.140Callithrix_jacchus
ENSG00000143799PARP19694.136ENSCAFG00000016089PARP110094.136Canis_familiaris
ENSG00000143799PARP110094.280ENSCAFG00020001660PARP110094.280Canis_lupus_dingo
ENSG00000143799PARP110090.954ENSCHIG00000018072PARP110090.954Capra_hircus
ENSG00000143799PARP19995.647ENSTSYG00000003699PARP110095.647Carlito_syrichta
ENSG00000143799PARP18793.103ENSCAPG00000011113-10076.561Cavia_aperea
ENSG00000143799PARP110092.998ENSCPOG00000015643-10092.998Cavia_porcellus
ENSG00000143799PARP110096.943ENSCCAG00000033484PARP110096.943Cebus_capucinus
ENSG00000143799PARP110098.225ENSCATG00000038981PARP110098.225Cercocebus_atys
ENSG00000143799PARP110093.097ENSCLAG00000006637PARP110093.097Chinchilla_lanigera
ENSG00000143799PARP18895.789ENSCHOG00000003539PARP16695.312Choloepus_hoffmanni
ENSG00000143799PARP110080.452ENSCPBG00000011958PARP110080.433Chrysemys_picta_bellii
ENSG00000143799PARP19997.639ENSCANG00000041340PARP110097.639Colobus_angolensis_palliatus
ENSG00000143799PARP110093.195ENSCGRG00001020559Parp110093.195Cricetulus_griseus_chok1gshd
ENSG00000143799PARP19993.224ENSCGRG00000004864Parp110093.224Cricetulus_griseus_crigri
ENSG00000143799PARP110069.667ENSCSEG00000020665parp19977.733Cynoglossus_semilaevis
ENSG00000143799PARP19969.746ENSCVAG00000021372parp19969.746Cyprinodon_variegatus
ENSG00000143799PARP110070.479ENSDARG00000019529parp110070.939Danio_rerio
ENSG00000143799PARP19691.770ENSDNOG00000012059PARP110092.181Dasypus_novemcinctus
ENSG00000143799PARP19990.862ENSDORG00000005234Parp110090.862Dipodomys_ordii
ENSG00000143799PARP19941.708FBgn0010247Parp9941.609Drosophila_melanogaster
ENSG00000143799PARP18796.094ENSETEG00000013254PARP18896.094Echinops_telfairi
ENSG00000143799PARP19958.191ENSEBUG00000005820parp110058.074Eptatretus_burgeri
ENSG00000143799PARP19894.980ENSEASG00005013275PARP19994.885Equus_asinus_asinus
ENSG00000143799PARP110095.168ENSECAG00000019207PARP110095.168Equus_caballus
ENSG00000143799PARP110088.692ENSEEUG00000012253PARP110088.692Erinaceus_europaeus
ENSG00000143799PARP19971.654ENSELUG00000017336parp110071.034Esox_lucius
ENSG00000143799PARP19791.939ENSFCAG00000005777PARP110092.551Felis_catus
ENSG00000143799PARP19978.403ENSFALG00000011578PARP110079.017Ficedula_albicollis
ENSG00000143799PARP19993.018ENSFDAG00000017662PARP110093.018Fukomys_damarensis
ENSG00000143799PARP19970.305ENSFHEG00000001117parp19970.305Fundulus_heteroclitus
ENSG00000143799PARP19969.951ENSGMOG00000014929parp19969.813Gadus_morhua
ENSG00000143799PARP110078.466ENSGALG00000009228PARP110079.371Gallus_gallus
ENSG00000143799PARP110070.059ENSGAFG00000010450parp110070.059Gambusia_affinis
ENSG00000143799PARP110069.141ENSGACG00000011280parp110069.434Gasterosteus_aculeatus
ENSG00000143799PARP110079.528ENSGAGG00000010066PARP110079.626Gopherus_agassizii
ENSG00000143799PARP110099.606ENSGGOG00000006308PARP110099.606Gorilla_gorilla
ENSG00000143799PARP110071.359ENSHBUG00000010490parp110071.359Haplochromis_burtoni
ENSG00000143799PARP19691.897ENSHGLG00000003992PARP19391.897Heterocephalus_glaber_female
ENSG00000143799PARP19691.897ENSHGLG00100016965PARP19391.897Heterocephalus_glaber_male
ENSG00000143799PARP110069.268ENSHCOG00000011619parp110069.659Hippocampus_comes
ENSG00000143799PARP110068.738ENSIPUG00000020250parp19969.336Ictalurus_punctatus
ENSG00000143799PARP110095.562ENSSTOG00000016000PARP110095.562Ictidomys_tridecemlineatus
ENSG00000143799PARP110091.330ENSJJAG00000023497Parp110091.330Jaculus_jaculus
ENSG00000143799PARP110071.024ENSKMAG00000011627parp110070.996Kryptolebias_marmoratus
ENSG00000143799PARP110070.841ENSLBEG00000013376parp110070.841Labrus_bergylta
ENSG00000143799PARP19958.333ENSLACG00000002735PARP110058.984Latimeria_chalumnae
ENSG00000143799PARP110072.576ENSLOCG00000015798parp110073.307Lepisosteus_oculatus
ENSG00000143799PARP19991.376ENSLAFG00000007830PARP110091.376Loxodonta_africana
ENSG00000143799PARP110098.126ENSMFAG00000002526PARP110098.126Macaca_fascicularis
ENSG00000143799PARP110098.225ENSMMUG00000021820PARP110098.225Macaca_mulatta
ENSG00000143799PARP110098.225ENSMNEG00000034074PARP110098.225Macaca_nemestrina
ENSG00000143799PARP110095.969ENSMLEG00000012344PARP110095.969Mandrillus_leucophaeus
ENSG00000143799PARP110071.583ENSMAMG00000020652parp110071.583Mastacembelus_armatus
ENSG00000143799PARP110071.554ENSMZEG00005016907parp110071.554Maylandia_zebra
ENSG00000143799PARP19978.710ENSMGAG00000007760PARP110079.141Meleagris_gallopavo
ENSG00000143799PARP110093.097ENSMAUG00000008306Parp110093.097Mesocricetus_auratus
ENSG00000143799PARP110092.012ENSMICG00000017076PARP110092.012Microcebus_murinus
ENSG00000143799PARP110092.702ENSMOCG00000014315Parp110092.702Microtus_ochrogaster
ENSG00000143799PARP110070.069ENSMMOG00000015966parp110070.069Mola_mola
ENSG00000143799PARP110083.776ENSMODG00000006076PARP110084.676Monodelphis_domestica
ENSG00000143799PARP110068.560ENSMALG00000004057parp110068.560Monopterus_albus
ENSG00000143799PARP110092.315MGP_CAROLIEiJ_G0014978Parp110093.878Mus_caroli
ENSG00000143799PARP110092.315ENSMUSG00000026496Parp19993.878Mus_musculus
ENSG00000143799PARP110092.315MGP_SPRETEiJ_G0015777Parp110093.878Mus_spretus
ENSG00000143799PARP110092.801ENSMPUG00000004585PARP110092.801Mustela_putorius_furo
ENSG00000143799PARP17694.118ENSMLUG00000012285PARP110075.791Myotis_lucifugus
ENSG00000143799PARP110092.110ENSNGAG00000003885Parp110092.604Nannospalax_galili
ENSG00000143799PARP110071.386ENSNBRG00000017434parp110071.386Neolamprologus_brichardi
ENSG00000143799PARP19598.451ENSNLEG00000013905PARP110098.451Nomascus_leucogenys
ENSG00000143799PARP16791.642ENSMEUG00000007720PARP18791.642Notamacropus_eugenii
ENSG00000143799PARP110093.590ENSOPRG00000011722PARP110093.590Ochotona_princeps
ENSG00000143799PARP110090.434ENSODEG00000007424PARP110090.434Octodon_degus
ENSG00000143799PARP110071.457ENSONIG00000013486parp110071.457Oreochromis_niloticus
ENSG00000143799PARP19982.600ENSOANG00000001488PARP110083.521Ornithorhynchus_anatinus
ENSG00000143799PARP110094.286ENSOCUG00000017820PARP110094.286Oryctolagus_cuniculus
ENSG00000143799PARP110069.765ENSORLG00000013691parp110069.765Oryzias_latipes
ENSG00000143799PARP19969.161ENSORLG00020001074parp19969.161Oryzias_latipes_hni
ENSG00000143799PARP110069.863ENSORLG00015007090parp110069.863Oryzias_latipes_hsok
ENSG00000143799PARP110093.590ENSOGAG00000016206PARP110093.590Otolemur_garnettii
ENSG00000143799PARP110091.150ENSOARG00000000811PARP110091.150Ovis_aries
ENSG00000143799PARP110099.408ENSPPAG00000040862PARP110099.408Pan_paniscus
ENSG00000143799PARP19691.684ENSPPRG00000003528PARP110092.402Panthera_pardus
ENSG00000143799PARP187100.000ENSPTIG00000009102PARP19878.421Panthera_tigris_altaica
ENSG00000143799PARP110099.408ENSPTRG00000002049PARP110099.408Pan_troglodytes
ENSG00000143799PARP110098.030ENSPANG00000011198PARP110098.030Papio_anubis
ENSG00000143799PARP110070.629ENSPKIG00000006039parp110071.246Paramormyrops_kingsleyae
ENSG00000143799PARP19978.491ENSPSIG00000016374PARP110079.328Pelodiscus_sinensis
ENSG00000143799PARP110067.121ENSPMGG00000008936parp110067.121Periophthalmus_magnuspinnatus
ENSG00000143799PARP110092.801ENSPEMG00000020230Parp110092.801Peromyscus_maniculatus_bairdii
ENSG00000143799PARP110082.776ENSPCIG00000006436PARP110087.758Phascolarctos_cinereus
ENSG00000143799PARP19970.079ENSPFOG00000002342parp19970.079Poecilia_formosa
ENSG00000143799PARP19970.768ENSPLAG00000000909parp19970.768Poecilia_latipinna
ENSG00000143799PARP19970.866ENSPMEG00000013979parp19970.866Poecilia_mexicana
ENSG00000143799PARP19970.768ENSPREG00000001114parp19970.768Poecilia_reticulata
ENSG00000143799PARP19999.383ENSPPYG00000000164PARP110099.383Pongo_abelii
ENSG00000143799PARP16595.062ENSPCAG00000005558-6595.062Procavia_capensis
ENSG00000143799PARP110094.773ENSPCOG00000016918PARP110094.773Propithecus_coquereli
ENSG00000143799PARP19294.340ENSPVAG00000005543PARP19294.340Pteropus_vampyrus
ENSG00000143799PARP110071.386ENSPNYG00000009702parp110071.386Pundamilia_nyererei
ENSG00000143799PARP110070.594ENSPNAG00000002787parp110070.789Pygocentrus_nattereri
ENSG00000143799PARP110091.626ENSRNOG00000003084Parp110091.429Rattus_norvegicus
ENSG00000143799PARP110097.929ENSRBIG00000044893PARP110097.929Rhinopithecus_bieti
ENSG00000143799PARP110097.929ENSRROG00000029280PARP110097.929Rhinopithecus_roxellana
ENSG00000143799PARP110068.701ENSRROG00000040615-10069.586Rhinopithecus_roxellana
ENSG00000143799PARP110096.548ENSSBOG00000010144PARP110096.548Saimiri_boliviensis_boliviensis
ENSG00000143799PARP19984.000ENSSHAG00000001991PARP110084.631Sarcophilus_harrisii
ENSG00000143799PARP110070.732ENSSFOG00015020017parp110070.732Scleropages_formosus
ENSG00000143799PARP110070.772ENSSMAG00000013799parp110070.772Scophthalmus_maximus
ENSG00000143799PARP110070.127ENSSDUG00000016626parp110070.127Seriola_dumerili
ENSG00000143799PARP110070.127ENSSLDG00000006384parp110070.127Seriola_lalandi_dorsalis
ENSG00000143799PARP15397.222ENSSARG00000009436-5997.222Sorex_araneus
ENSG00000143799PARP110075.862ENSSPUG00000007790PARP110076.552Sphenodon_punctatus
ENSG00000143799PARP110069.080ENSSPAG00000019074parp110070.256Stegastes_partitus
ENSG00000143799PARP110093.688ENSSSCG00000023660PARP110093.688Sus_scrofa
ENSG00000143799PARP19779.245ENSTGUG00000004260-10079.578Taeniopygia_guttata
ENSG00000143799PARP110069.902ENSTRUG00000014490parp110069.902Takifugu_rubripes
ENSG00000143799PARP110069.561ENSTNIG00000016384parp110069.561Tetraodon_nigroviridis
ENSG00000143799PARP18297.872ENSTBEG00000002364PARP19297.872Tupaia_belangeri
ENSG00000143799PARP110088.560ENSTTRG00000000188PARP110088.560Tursiops_truncatus
ENSG00000143799PARP19993.641ENSUAMG00000014388PARP110093.641Ursus_americanus
ENSG00000143799PARP18498.113ENSUMAG00000014555PARP19983.590Ursus_maritimus
ENSG00000143799PARP18898.947ENSVPAG00000011411PARP18497.744Vicugna_pacos
ENSG00000143799PARP19694.239ENSVVUG00000001655PARP110094.239Vulpes_vulpes
ENSG00000143799PARP19872.954ENSXETG00000022610parp19973.848Xenopus_tropicalis
ENSG00000143799PARP19969.783ENSXMAG00000003632parp19969.783Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-TASProcess
GO:0000715nucleotide-excision repair, DNA damage recognition-TASProcess
GO:0000717nucleotide-excision repair, DNA duplex unwinding-TASProcess
GO:0000723telomere maintenance25749521.TASProcess
GO:0000724double-strand break repair via homologous recombination-TASProcess
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding11112786.IDAFunction
GO:0001228DNA-binding transcription activator activity, RNA polymerase II-specific11112786.IDAFunction
GO:0003677DNA binding2513174.TASFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003950NAD+ ADP-ribosyltransferase activity21873635.IBAFunction
GO:0003950NAD+ ADP-ribosyltransferase activity7852410.16107709.17396150.19470756.19764761.23275542.IDAFunction
GO:0003950NAD+ ADP-ribosyltransferase activity22504299.IMPFunction
GO:0003950NAD+ ADP-ribosyltransferase activity-TASFunction
GO:0005515protein binding7596430.9518481.11248244.14596914.14627987.14734561.15044383.15555565.16490787.17167422.17396150.18172500.18971944.19661379.19666485.19710015.19779455.20064938.20098424.20133863.21266351.21549307.21575865.21577210.22504299.22863007.23230272.23396353.23481255.23966166.24778456.25533949.25640309.25749521.26344098.27067600.27248496.27728808.28190768.30356214.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus17177976.22504299.IDAComponent
GO:0005635nuclear envelope9518481.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005667transcription factor complex19303849.IDAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus9518481.16107709.IDAComponent
GO:0005739mitochondrion25378300.IDAComponent
GO:0006281DNA repair17396150.TASProcess
GO:0006293nucleotide-excision repair, preincision complex stabilization-TASProcess
GO:0006294nucleotide-excision repair, preincision complex assembly-TASProcess
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesion-TASProcess
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TASProcess
GO:0006302double-strand break repair21873635.IBAProcess
GO:0006302double-strand break repair23230272.IMPProcess
GO:0006366transcription by RNA polymerase II10944198.TASProcess
GO:0006471protein ADP-ribosylation7852410.17396150.26344098.27067600.IDAProcess
GO:0006471protein ADP-ribosylation22504299.IMPProcess
GO:0006915apoptotic process15565177.IDAProcess
GO:0006974cellular response to DNA damage stimulus24289924.24550317.27067600.27248496.IMPProcess
GO:0007005mitochondrion organization25378300.IMPProcess
GO:0007179transforming growth factor beta receptor signaling pathway-IEAProcess
GO:0008134transcription factor binding19303849.IPIFunction
GO:0008270zinc ion binding-IEAFunction
GO:0010332response to gamma radiation-IEAProcess
GO:0010613positive regulation of cardiac muscle hypertrophy-ISSProcess
GO:0010990regulation of SMAD protein complex assembly-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016540protein autoprocessing-IEAProcess
GO:0018312peptidyl-serine ADP-ribosylation28190768.IDAProcess
GO:0018424peptidyl-glutamic acid poly-ADP-ribosylation19764761.IDAProcess
GO:0019899enzyme binding23382074.IPIFunction
GO:0019901protein kinase binding17177976.IPIFunction
GO:0023019signal transduction involved in regulation of gene expression-IEAProcess
GO:0030225macrophage differentiation18309324.TASProcess
GO:0030331estrogen receptor binding-IEAFunction
GO:0030592DNA ADP-ribosylation27471034.IDAProcess
GO:0032042mitochondrial DNA metabolic process25378300.IMPProcess
GO:0032869cellular response to insulin stimulus19303849.IDAProcess
GO:0032991protein-containing complex22504299.25378300.IDAComponent
GO:0032993protein-DNA complex22504299.IDAComponent
GO:0033148positive regulation of intracellular estrogen receptor signaling pathway-IEAProcess
GO:0033683nucleotide-excision repair, DNA incision-TASProcess
GO:0034599cellular response to oxidative stress25378300.IMPProcess
GO:0034644cellular response to UV24289924.IMPProcess
GO:0035861site of double-strand break26344098.30356214.IDAComponent
GO:0036211protein modification process25378300.IMPProcess
GO:0042769DNA damage response, detection of DNA damage-IEAProcess
GO:0042802identical protein binding14734561.23481255.IPIFunction
GO:0042826histone deacetylase binding-IEAFunction
GO:0043504mitochondrial DNA repair25378300.IMPProcess
GO:0044030regulation of DNA methylation-IEAProcess
GO:0045944positive regulation of transcription by RNA polymerase II11112786.IDAProcess
GO:0047485protein N-terminus binding16107709.IPIFunction
GO:0050790regulation of catalytic activity25749521.IDAProcess
GO:0051287NAD binding-IEAFunction
GO:0051901positive regulation of mitochondrial depolarization-IEAProcess
GO:0060391positive regulation of SMAD protein signal transduction-IEAProcess
GO:0070212protein poly-ADP-ribosylation21873635.IBAProcess
GO:0070212protein poly-ADP-ribosylation15674325.19470756.25043379.IDAProcess
GO:0070213protein auto-ADP-ribosylation19764761.IDAProcess
GO:0070412R-SMAD binding-IEAFunction
GO:0070911global genome nucleotide-excision repair-TASProcess
GO:0071294cellular response to zinc ion-IEAProcess
GO:0090734site of DNA damage27248496.IMPComponent
GO:1900182positive regulation of protein localization to nucleus-IEAProcess
GO:1901216positive regulation of neuron death-IEAProcess
GO:1903376regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-IEAProcess
GO:1903518positive regulation of single strand break repair28002403.IGIProcess
GO:1903827regulation of cellular protein localization24550317.IMPProcess
GO:1904044response to aldosterone-IEAProcess
GO:1904357negative regulation of telomere maintenance via telomere lengthening-ISSProcess
GO:1904646cellular response to amyloid-beta-IEAProcess
GO:1904762positive regulation of myofibroblast differentiation-IEAProcess
GO:1905168positive regulation of double-strand break repair via homologous recombination26344098.30356214.IDAProcess
GO:1990404protein ADP-ribosylase activity21873635.IBAFunction
GO:1990404protein ADP-ribosylase activity7852410.19764761.25043379.26344098.28190768.IDAFunction
GO:1990966ATP generation from poly-ADP-D-ribose27257257.IDAProcess
GO:2000679positive regulation of transcription regulatory region DNA binding-IEAProcess
GO:2001170negative regulation of ATP biosynthetic process24289924.IMPProcess
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