EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18262048Low molecular weight protein tyrosine phosphatase genetic polymorphism and susceptibility to cancer development.Cancer Genet Cytogenet2008 FebAlho Idoi: 10.1016/j.cancergencyto.2007.11.004.
27127127Low Molecular Weight Protein Tyrosine Phosphatase Slow Isoform Knockdown in MDA-MB-435 Cells Decreases RAW 264.7 Osteoclastic Differentiation.Anticancer Res2016 MayAlho I-
23645747Characterization of low molecular weight protein tyrosine phosphatase isoforms in human breast cancer epithelial cell lines.Anticancer Res2013 MayAlho I-
16036221Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.Biochem Biophys Res Commun2005 Sep 2Malentacchi F-
18786445ACP1 genetic polymorphism and colon cancer.Cancer Genet Cytogenet2008 OctSpina Cdoi: 10.1016/j.cancergencyto.2008.06.006.
26159288Low-Molecular-Weight Protein Tyrosine Phosphatase Predicts Prostate Cancer Outcome by Increasing the Metastatic Potential.Eur Urol2016 AprRuela-de-Sousa RRdoi: 10.1016/j.eururo.2015.06.040
22692348Acid phosphatase locus 1 genetic polymorphism and cancer grading.Am J Med Sci2012 JulGloria-Bottini Fdoi: 10.1097/MAJ.0b013e31823e5cfa.
29187443Total Knockdown of LMW-PTP in MDA-MB-231 Cells Reduces Osteoclastogenesis.Anticancer Res2017 DecSapinho G-
30326476Prediction of Time to Castration-Resistant Prostate Cancer Using Low-Molecular-Weight Protein Tyrosine Phosphatase Expression for Men with Metastatic Hormone-Nave Prostate Cancer.Urol Int2019Miyoshi Ydoi: 10.1159/000493324

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2272114SilentnovelK65K0.56
BLCAchr2264987Missense_MutationNAS8Y0.05
BLCAchr2275176SilentNAL90L0.11
BLCAchr2272238Intronnovel0.13
BRCAchr2264982SilentnovelT6T0.16
CESCchr2272070Missense_MutationNAE51Q0.29
COADchr2271878Missense_Mutationrs769115575R19Q0.29
COADchr2277042Missense_MutationNAS119N0.35
COADchr22774913'UTRnovel0.44
COADchr2272415IntronNA0.36
COADchr2275179Missense_MutationnovelC91R0.18
COADchr2272081Frame_Shift_DelNAP56Lfs*90.39
COADchr2272080Frame_Shift_InsNAD57*0.34
COADchr2277274Nonsense_MutationNAC149*0.21
COADchr2272232Intronrs7639124380.25
ESCAchr2271940Splice_SitenovelX40_splice0.12
GBMchr22649195'UTRnovel0.21
GBMchr2272312Intronnovel0.08
HNSCchr2271881Missense_MutationnovelS20L0.08
HNSCchr22649145'UTRnovel0.34
KIRCchr22649375'UTRnovel0.22
KIRCchr22773623'UTRnovel0.07
KIRCchr22773633'UTRnovel0.03
LAMLchr22649455'UTRnovel0.4
LGGchr2277249Missense_Mutationrs375641056T141M0.4
LIHCchr2277266Missense_MutationNAV147I0.09
LIHCchr22649605'UTRnovel0.52
LIHCchr2277013SilentNAT109T0.15
LIHCchr22774393'UTRnovel0.45
LUADchr2275160SilentnovelA84A0.15
LUADchr2272282IntronNA0.34
LUADchr2277071Missense_MutationnovelE129Q0.26
LUADchr22649645'UTRnovel0.08
LUADchr2272088Missense_MutationnovelD57Y0.26
LUADchr2277226Splice_SiteNAX134_splice0.25
LUSCchr22649375'UTRnovel0.19
LUSCchr22649195'UTRnovel0.06
LUSCchr2272235IntronNA0.7
LUSCchr2272236IntronNA0.7
LUSCchr2277020Missense_MutationNAA112P0.35
LUSCchr22773353'UTRnovel0.13
LUSCchr22773673'UTRnovel0.14
LUSCchr22648945'UTRnovel0.19
OVchr2277297Missense_MutationnovelA157D0.05
OVchr2272227IntronNA0.19
OVchr22773473'UTRnovel0.11
OVchr22649325'UTRnovel0.16
OVchr2272228Intronrs7754437980.11
OVchr2277055SilentnovelQ123Q0.04
PAADchr22773253'UTRrs5299066390.07
PRADchr2271876Missense_MutationnovelC18W0.5
PRADchr22648865'UTRnovel0.29
PRADchr22648865'UTRnovel0.43
PRADchr2272206Intronrs7814414690.56
SKCMchr22773133'UTRrs5475724040.28
SKCMchr2272235IntronNA0.2
SKCMchr2272289Intronnovel0.32
SKCMchr2277050Missense_MutationNAP122S0.34
SKCMchr2277292Silentrs150164591E155E0.33
SKCMchr2272128Missense_MutationNAP70L0.25
SKCMchr2272154Splice_Regionnovel0.35
SKCMchr2271865Splice_SiteNAX15_splice0.49
STADchr2272122Missense_MutationnovelG68D0.2
STADchr2277054Frame_Shift_DelnovelK124Nfs*610.17
STADchr2277054Frame_Shift_DelnovelK124Nfs*610.2
STADchr2277054Frame_Shift_DelnovelK124Nfs*610.33
STADchr2272130Missense_MutationnovelM71V0.1
STADchr2271876SilentNAC18C0.19
STADchr2272055Missense_MutationNAA46T0.34
STADchr2277054Frame_Shift_DelnovelK124Nfs*610.49
UCECchr2277002Nonsense_Mutationrs553260669Q106*0.4
UCECchr22774953'UTRNA0.38
UCECchr2272206Intronrs7814414690.2
UCECchr2272215Intronnovel0.28
UCECchr2272362Intronrs3690858130.11
UCECchr22773613'UTRnovel0.14
UCECchr2272236IntronNA0.22
UCECchr2271932Missense_MutationnovelS37L0.35
UCECchr2272197Intronnovel0.37
UCECchr2272347Intronnovel0.34
UCECchr2272492Intronnovel0.18
UCECchr2272493Intronnovel0.2
UCECchr22775033'UTRnovel0.21
UCECchr2272202IntronNA0.36
UCECchr2272325Intronnovel0.07

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.31620.033813
CESCAMP0.23390.099937
KIRPDEL0.02780.08832
LUSCDEL0.07390.20634
OVDEL0.16410.087942
PAADDEL0.09240.2014
SARCDEL0.32683.2554e-05
TGCTAMP0.280.0050216
UCECDEL0.03710.18809

Survival Analysis
CancerP-value Q-value
THYM0.0028

Kaplan-Meier Survival Analysis

KIRC0.00048

Kaplan-Meier Survival Analysis

ACC0.00075

Kaplan-Meier Survival Analysis

LUSC0.004

Kaplan-Meier Survival Analysis

PCPG0.025

Kaplan-Meier Survival Analysis

UCEC0.0098

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.0012

Kaplan-Meier Survival Analysis

LUAD0.018

Kaplan-Meier Survival Analysis

OV0.044

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000143727 (Gene tree)
Gene ID
52
Gene Symbol
ACP1
Alias
HAAP|LMW-PTP|LMWPTP
Full Name
acid phosphatase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
14,144 bases
Position
chr2:264,140-278,283
Accession
122
RBP type
non-canonical RBP
Summary
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000442386ACP1-208546-ENSP0000038968146 (aa)-F2Z2R9
ENST00000407983ACP1-205703-ENSP00000385404112 (aa)-P24666
ENST00000413140ACP1-206689-ENSP0000041033180 (aa)-G5E9R5
ENST00000453390ACP1-209577-ENSP0000041112170 (aa)-F2Z2Q9
ENST00000484125ACP1-212559--- (aa)--
ENST00000480874ACP1-211732--- (aa)--
ENST00000405233ACP1-2031149-ENSP0000038430770 (aa)-F2Z2Q9
ENST00000272067ACP1-2021552-ENSP00000272067158 (aa)-P24666
ENST00000272065ACP1-2011549-ENSP00000272065158 (aa)-P24666
ENST00000463831ACP1-2101015--- (aa)--
ENST00000439645ACP1-207605-ENSP0000040859685 (aa)-D3YTI2
ENST00000484464ACP1-213573--- (aa)--
ENST00000405364ACP1-204414-ENSP0000038418446 (aa)-F2Z2R9
Gene Model
Click here to download ENSG00000143727's gene model file
Pathways
Pathway IDPathway NameSource
hsa00730Thiamine metabolismKEGG
hsa00740Riboflavin metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa04520Adherens junctionKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000143727rs797160742277003GBlood protein levels29875488[1.12-1.2] unit increase1.16EFO_0007937
ENSG00000143727rs115537462272203TBlood protein levels28240269[1.19-1.29] unit increase1.237EFO_0008213
ENSG00000143727rs584616062267367GBlood protein levels30072576[1.1-1.17] unit decrease1.134EFO_0007937
ENSG00000143727rs599374732271797ASmoking initiation (ever regular vs never regular) (MTAG)30643251[0.0037-0.0081] unit decrease0.00590285EFO_0006527
ENSG00000143727rs1149761762264621CSmoking initiation (ever regular vs never regular)30643251[0.01-0.021] unit decrease0.015513658EFO_0006527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143727's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003993acid phosphatase activity-IEAFunction
GO:0004725protein tyrosine phosphatase activity21873635.IBAFunction
GO:0004726non-membrane spanning protein tyrosine phosphatase activity-IEAFunction
GO:0005515protein binding9499402.15846844.25556234.IPIFunction
GO:0005737cytoplasm10940933.IDAComponent
GO:0009898cytoplasmic side of plasma membrane10940933.IDAComponent
GO:0035335peptidyl-tyrosine dephosphorylation-IEAProcess
GO:0070062extracellular exosome19056867.23533145.HDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us