EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15986435	TP53BP2 locus is associated with gastric cancer susceptibility.	Int J Cancer	2005 Dec 20	Ju H	-
22552744	Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.	Oncol Rep	2012 Jul	Li S	doi: 10.3892/or.2012.1778
21562218	Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.	Proc Natl Acad Sci U S A	2011 May 31	Buti L	doi: 10.1073/pnas.1106200108
26663100	miR-548d-3p/TP53BP2 axis regulates the proliferation andapoptosis of breast cancer cells.	Cancer Med	2016 Feb	Song Q	doi: 10.1002/cam4.567
26438046	Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation.	Mol Cancer	2015 Oct 5	Song B	doi: 10.1186/s12943-015-0447-5.
23528480	Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP2 and iASPP in gastric cancer and precancerous lesions.	Pathol Biol (Paris)	2013 Oct	Meng WD	doi: 10.1016/j.patbio.2013.02.002
22169642	[Promoter methylation of ASPP1 and ASPP2 genes in non-small cell lung cancers].	Zhonghua Bing Li Xue Za Zhi	2011 Aug	Wei WL	-
27437940	ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold.	PLoS One	2016 Jul 20	Posada IM	doi: 10.1371/journal.pone.0159677
28400336	ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.	Cancer Lett	2017 Jul 10	Gen Y	doi: 10.1016/j.canlet.2017.04.002
29568874	Silencing of ASPP2 promotes the proliferation, migration and invasion of triple-negative breast cancer cells via the PI3K/AKT pathway.	Int J Oncol	2018 Jun	Wu T	doi: 10.3892/ijo.2018.4331

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	223789164	Missense_Mutation	NA	H1003Y	0.18
BLCA	chr1	223804253	Silent	novel	E190E	0.07
BLCA	chr1	223796273	Nonsense_Mutation	novel	Q756*	0.3
BLCA	chr1	223793335	Missense_Mutation	novel	E944K	0.44
BLCA	chr1	223845735	5'UTR	novel		0.33
BLCA	chr1	223798492	Silent	rs765016756	P557P	0.3
BLCA	chr1	223793405	Silent	novel	E920E	0.14
BLCA	chr1	223789029	Nonsense_Mutation	novel	Q1048*	0.41
BLCA	chr1	223806908	Nonsense_Mutation	NA	Q138*	0.32
BLCA	chr1	223796585	Missense_Mutation	NA	G652S	0.32
BLCA	chr1	223796437	Missense_Mutation	NA	R701Q	0.48
BLCA	chr1	223795976	Missense_Mutation	NA	E855K	0.15
BLCA	chr1	223799969	Missense_Mutation	novel	S472F	0.46
BLCA	chr1	223796297	Missense_Mutation	novel	E748K	0.29
BLCA	chr1	223784189	Missense_Mutation	novel	D1097H	0.17
BLCA	chr1	223821227	Silent	novel	C56C	0.07
BLCA	chr1	223784240	Missense_Mutation	novel	D1080Y	0.08
BLCA	chr1	223802151	Missense_Mutation	novel	P397H	0.2
BLCA	chr1	223802179	Missense_Mutation	novel	E388K	0.51
BLCA	chr1	223796215	Nonsense_Mutation	NA	S775*	0.95
BLCA	chr1	223802217	Missense_Mutation	rs767048169	P375L	0.11
BRCA	chr1	223784114	Splice_Site	NA	X1121_splice	0.08
BRCA	chr1	223784199	Missense_Mutation	NA	I1093M	0.67
BRCA	chr1	223780813	3'UTR	novel		0.16
BRCA	chr1	223802580	Intron	novel		0.24
BRCA	chr1	223803355	Missense_Mutation	NA	E249D	0.35
BRCA	chr1	223803294	Missense_Mutation	NA	D270N	0.34
BRCA	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.12
BRCA	chr1	223802188	Missense_Mutation	NA	Q385E	0.25
BRCA	chr1	223804228	Frame_Shift_Ins	novel	*V199Sfs5**	0.15
BRCA	chr1	223798386	Missense_Mutation	novel	P593S	0.08
BRCA	chr1	223799993	Missense_Mutation	NA	S464L	0.18
BRCA	chr1	223814308	Missense_Mutation	NA	R74Q	0.31
BRCA	chr1	223796215	Nonsense_Mutation	NA	S775*	0.24
BRCA	chr1	223796354	Frame_Shift_Ins	novel	*K729Pfs11**	0.06
BRCA	chr1	223796559	Silent	novel	Q660Q	0.08
BRCA	chr1	223796401	Missense_Mutation	rs189590424	S713Y	0.12
CESC	chr1	223796019	Silent	novel	P840P	0.22
CESC	chr1	223803378	Missense_Mutation	novel	E242K	0.13
CESC	chr1	223800045	Missense_Mutation	NA	D447N	0.25
CESC	chr1	223818230	Intron	novel		0.32
CESC	chr1	223814315	Missense_Mutation	novel	L72V	0.13
CESC	chr1	223784226	Missense_Mutation	NA	M1084I	0.42
COAD	chr1	223796235	Missense_Mutation	novel	M768I	0.12
COAD	chr1	223814282	Missense_Mutation	rs200028775	R83C	0.3
COAD	chr1	223792462	Missense_Mutation	NA	A975T	0.33
COAD	chr1	223814270	Missense_Mutation	rs376720051	R87C	0.26
COAD	chr1	223814351	Missense_Mutation	rs771266375	R60C	0.6
COAD	chr1	223800003	Missense_Mutation	rs755330448	R461C	0.09
COAD	chr1	223802305	Missense_Mutation	NA	A346T	0.43
COAD	chr1	223796340	Silent	rs756919731	N733N	0.35
COAD	chr1	223792429	Nonsense_Mutation	NA	Q986*	0.25
COAD	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.52
COAD	chr1	223799909	Missense_Mutation	rs756133979	R492Q	0.28
COAD	chr1	223802346	Splice_Site	NA	X333_splice	0.12
COAD	chr1	223798396	Silent	NA	R589R	0.39
COAD	chr1	223792392	Missense_Mutation	NA	G998E	0.07
COAD	chr1	223803394	Silent	NA	L236L	0.34
COAD	chr1	223798652	Missense_Mutation	NA	V504A	0.34
COAD	chr1	223814309	Nonsense_Mutation	NA	R74*	0.42
ESCA	chr1	223814269	Missense_Mutation	novel	R87L	0.1
ESCA	chr1	223795904	Missense_Mutation	novel	P879T	0.18
ESCA	chr1	223789078	Missense_Mutation	novel	D1031E	0.08
GBM	chr1	223806892	Missense_Mutation	rs766049032	R143H	0.3
GBM	chr1	223793406	Missense_Mutation	novel	E920A	0.03
GBM	chr1	223789066	Silent	novel	A1035A	0.14
GBM	chr1	223799998	Silent	rs138649239	P462P	0.22
GBM	chr1	223803393	Missense_Mutation	novel	A237T	0.45
GBM	chr1	223796215	Missense_Mutation	novel	S775L	0.07
GBM	chr1	223799986	Silent	novel	F466F	0.23
GBM	chr1	223802251	Missense_Mutation	rs372619455	R364W	0.5
GBM	chr1	223798615	Frame_Shift_Ins	novel	*L517Vfs122**	0.06
GBM	chr1	223798666	Frame_Shift_Ins	novel	*K499Nfs5**	0.12
HNSC	chr1	223799948	Missense_Mutation	novel	G479D	0.15
HNSC	chr1	223804229	Frame_Shift_Del	NA	V199*	0.28
HNSC	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.24
HNSC	chr1	223802335	Missense_Mutation	novel	D336N	0.12
HNSC	chr1	223796155	Missense_Mutation	novel	N795S	0.17
HNSC	chr1	223803400	Silent	NA	L234L	0.19
HNSC	chr1	223796430	Silent	novel	L703L	0.27
HNSC	chr1	223821351	Missense_Mutation	novel	Y15C	0.27
KIRC	chr1	223806897	Silent	rs764316574	A141A	0.23
KIRC	chr1	223796151	Silent	NA	P796P	0.35
KIRC	chr1	223796253	Silent	NA	R762R	0.24
KIRP	chr1	223796397	Silent	NA	N714N	0.23
KIRP	chr1	223795929	Missense_Mutation	NA	E870D	0.24
KIRP	chr1	223802222	Frame_Shift_Del	novel	*K374Sfs18**	0.31
LGG	chr1	223796258	Nonsense_Mutation	novel	*Q761Ffs5**	0.15
LIHC	chr1	223780870	Missense_Mutation	NA	Q1130E	0.07
LIHC	chr1	223821338	Missense_Mutation	NA	N19K	0.47
LIHC	chr1	223796560	Missense_Mutation	novel	Q660R	0.17
LIHC	chr1	223814330	Nonsense_Mutation	NA	R67*	0.13
LIHC	chr1	223796060	Missense_Mutation	NA	S827C	0.15
LUAD	chr1	223806905	Missense_Mutation	novel	E139Q	0.24
LUAD	chr1	223802764	Silent	NA	K321K	0.14
LUAD	chr1	223798291	Silent	NA	A624A	0.69
LUAD	chr1	223796584	Missense_Mutation	NA	G652A	0.09
LUAD	chr1	223804249	Nonsense_Mutation	novel	Q192*	0.14
LUAD	chr1	223800809	In_Frame_Ins	novel	G409_S410insL	0.1
LUAD	chr1	223810474	Frame_Shift_Ins	novel	*N110Ifs8**	0.06
LUAD	chr1	223802785	Silent	NA	L314L	0.37
LUAD	chr1	223802472	Intron	novel		0.5
LUAD	chr1	223795853	Missense_Mutation	NA	R896C	0.05
LUSC	chr1	223800002	Missense_Mutation	novel	R461L	0.21
LUSC	chr1	223798471	Silent	novel	S564S	0.12
LUSC	chr1	223784163	Missense_Mutation	novel	W1105C	0.39
LUSC	chr1	223821355	Missense_Mutation	NA	V14L	0.18
LUSC	chr1	223784152	Missense_Mutation	novel	N1109S	0.06
LUSC	chr1	223802147	Silent	NA	N398N	0.15
LUSC	chr1	223800019	Missense_Mutation	novel	E455D	0.35
LUSC	chr1	223789176	Splice_Site	novel	X999_splice	0.12
LUSC	chr1	223784211	Silent	novel	C1089C	0.31
OV	chr1	223796345	Missense_Mutation	novel	S732T	0.04
OV	chr1	223780889	Nonsense_Mutation	novel	Y1123*	0.05
OV	chr1	223798384	Silent	rs776132793	P593P	0.1
OV	chr1	223802827	Silent	novel	R300R	0.08
OV	chr1	223784217	Silent	novel	G1087G	0.28
OV	chr1	223796362	Missense_Mutation	novel	A726G	0.03
OV	chr1	223798285	Silent	novel	G626G	0.05
OV	chr1	223792519	Missense_Mutation	NA	D956H	0.32
OV	chr1	223802819	Missense_Mutation	NA	E303G	0.26
PAAD	chr1	223798335	Missense_Mutation	NA	V610M	0.04
PAAD	chr1	223795852	Missense_Mutation	novel	R896H	0.2
PRAD	chr1	223792517	Splice_Site	novel	X955_splice	0.21
PRAD	chr1	223792485	Missense_Mutation	novel	T967M	0.3
PRAD	chr1	223798624	Frame_Shift_Del	novel	*K513Nfs125**	0.93
PRAD	chr1	223798257	Frame_Shift_Del	novel	*A636Rfs2**	0.03
PRAD	chr1	223804207	Missense_Mutation	novel	V206M	0.34
READ	chr1	223780872	Missense_Mutation	novel	R1129I	0.36
SARC	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.35
SARC	chr1	223806895	Missense_Mutation	novel	S142F	0.32
SARC	chr1	223799954	Missense_Mutation	novel	S477F	0.21
SKCM	chr1	223800795	Missense_Mutation	NA	P414L	0.34
SKCM	chr1	223795898	Missense_Mutation	NA	P881S	0.46
SKCM	chr1	223798638	Missense_Mutation	novel	P509S	0.45
SKCM	chr1	223798490	Missense_Mutation	NA	R558K	0.32
SKCM	chr1	223784300	Missense_Mutation	novel	M1060L	0.39
SKCM	chr1	223796527	Missense_Mutation	NA	S671F	0.7
SKCM	chr1	223802599	Intron	novel		0.52
SKCM	chr1	223796527	Missense_Mutation	NA	S671F	0.09
SKCM	chr1	223802171	Silent	rs142207720	P390P	0.25
SKCM	chr1	223796483	Missense_Mutation	NA	P686S	0.44
SKCM	chr1	223802756	Missense_Mutation	NA	A324V	0.49
SKCM	chr1	223796253	Silent	NA	R762R	0.21
SKCM	chr1	223821357	Missense_Mutation	novel	T13I	0.35
SKCM	chr1	223803334	Silent	rs747622630	I256I	0.29
SKCM	chr1	223799908	Silent	novel	R492R	0.45
SKCM	chr1	223799909	Missense_Mutation	rs756133979	R492Q	0.45
SKCM	chr1	223803400	Silent	NA	L234L	0.33
SKCM	chr1	223799905	Missense_Mutation	NA	D493E	0.44
SKCM	chr1	223814315	Missense_Mutation	rs757047375	L72F	0.35
SKCM	chr1	223821263	Silent	rs781742013	P44P	0.94
SKCM	chr1	223821264	Missense_Mutation	rs746194354	P44L	0.94
SKCM	chr1	223804183	Missense_Mutation	NA	G214R	0.25
SKCM	chr1	223795902	Silent	novel	P879P	0.3
SKCM	chr1	223796440	Missense_Mutation	NA	P700L	0.46
SKCM	chr1	223803400	Silent	NA	L234L	0.82
STAD	chr1	223804229	Frame_Shift_Del	NA	V199*	0.17
STAD	chr1	223798279	Frame_Shift_Ins	novel	*N628Kfs26**	0.21
STAD	chr1	223802191	Missense_Mutation	NA	I384V	0.11
STAD	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.22
STAD	chr1	223802323	Missense_Mutation	NA	P340S	0.31
STAD	chr1	223796301	Silent	NA	E746E	0.25
STAD	chr1	223800807	Missense_Mutation	NA	S410Y	0.18
STAD	chr1	223784219	Nonsense_Mutation	NA	G1087*	0.11
STAD	chr1	223798506	Missense_Mutation	NA	A553T	0.23
STAD	chr1	223804229	Frame_Shift_Del	NA	V199*	0.49
STAD	chr1	223796260	Missense_Mutation	NA	Y760C	0.39
STAD	chr1	223789150	Silent	NA	S1007S	0.33
STAD	chr1	223800002	Missense_Mutation	rs762131208	R461H	0.18
STAD	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.06
STAD	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.31
STAD	chr1	223804229	Frame_Shift_Del	NA	V199*	0.17
STAD	chr1	223821360	Missense_Mutation	NA	L12P	0.17
STAD	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.64
THCA	chr1	223798645	Silent	novel	P506P	0.39
THYM	chr1	223814351	Missense_Mutation	rs771266375	R60C	0.18
UCEC	chr1	223798257	Missense_Mutation	NA	A636T	0.41
UCEC	chr1	223793316	Missense_Mutation	NA	R950I	0.26
UCEC	chr1	223810477	Missense_Mutation	rs777720999	R109I	0.28
UCEC	chr1	223814288	Missense_Mutation	rs373088845	E81K	0.1
UCEC	chr1	223798279	Frame_Shift_Ins	novel	*N628Kfs26**	0.36
UCEC	chr1	223802828	Missense_Mutation	rs781150076	R300H	0.39
UCEC	chr1	223804319	Missense_Mutation	novel	Q168H	0.33
UCEC	chr1	223799982	Missense_Mutation	NA	A468T	0.05
UCEC	chr1	223784268	Silent	rs760742112	A1070A	0.38
UCEC	chr1	223798614	Silent	novel	L517L	0.37
UCEC	chr1	223802134	Missense_Mutation	novel	A403T	0.43
UCEC	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.27
UCEC	chr1	223796494	Missense_Mutation	novel	P682H	0.39
UCEC	chr1	223789026	Missense_Mutation	novel	C1049R	0.07
UCEC	chr1	223802205	Missense_Mutation	NA	D379G	0.44
UCEC	chr1	223814329	Missense_Mutation	rs180972416	R67Q	0.12
UCEC	chr1	223784207	Missense_Mutation	novel	T1091P	0.49
UCEC	chr1	223798468	Missense_Mutation	novel	I565M	0.39
UCEC	chr1	223798599	Missense_Mutation	novel	Q522E	0.41
UCEC	chr1	223818268	Intron	novel		0.36
UCEC	chr1	223780881	Missense_Mutation	novel	I1126S	0.17
UCEC	chr1	223784175	Silent	rs146041419	I1101I	0.29
UCEC	chr1	223796132	Missense_Mutation	rs140957045	E803K	0.22
UCEC	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.22
UCEC	chr1	223798498	Missense_Mutation	novel	Q555H	0.45
UCEC	chr1	223784175	Silent	rs146041419	I1101I	0.1
UCEC	chr1	223798388	In_Frame_Ins	novel	T592delinsKP	0.09
UCEC	chr1	223800744	Missense_Mutation	novel	G431V	0.06
UCEC	chr1	223803291	Missense_Mutation	rs751721084	R271C	0.24
UCEC	chr1	223804342	Missense_Mutation	rs777840586	R161C	0.09
UCEC	chr1	223795891	Missense_Mutation	novel	G883E	0.15
UCEC	chr1	223796119	Missense_Mutation	NA	V807A	0.26
UCEC	chr1	223798304	Missense_Mutation	rs202075602	T620M	0.45
UCEC	chr1	223795973	Nonsense_Mutation	rs749127092	E856*	0.34
UCEC	chr1	223796322	Missense_Mutation	NA	K739N	0.41
UCEC	chr1	223795852	Missense_Mutation	novel	R896H	0.19
UCEC	chr1	223796466	Silent	novel	Q691Q	0.19
UCEC	chr1	223818254	Intron	novel		0.19
UCEC	chr1	223795825	Missense_Mutation	novel	S905F	0.19
UCEC	chr1	223804207	Missense_Mutation	novel	V206M	0.28
UCEC	chr1	223798332	Missense_Mutation	novel	A611T	0.42
UCEC	chr1	223793335	Nonsense_Mutation	novel	E944*	0.22
UCEC	chr1	223796389	Missense_Mutation	rs769229662	R717Q	0.4
UCEC	chr1	223792445	Silent	rs754482610	I980I	0.42
UCEC	chr1	223796317	Missense_Mutation	novel	R741H	0.49
UCEC	chr1	223821294	Missense_Mutation	NA	C34Y	0.39
UCEC	chr1	223806925	Missense_Mutation	novel	L132P	0.26
UCEC	chr1	223796191	Missense_Mutation	novel	V783A	0.04
UCEC	chr1	223804229	Frame_Shift_Del	NA	V199*	0.34
UCEC	chr1	223780762	3'UTR	novel		0.27
UCEC	chr1	223796363	Missense_Mutation	NA	A726T	0.19
UCEC	chr1	223798384	Silent	novel	P593P	0.32
UCEC	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.62
UCEC	chr1	223800034	Missense_Mutation	novel	E450D	0.2
UCEC	chr1	223780823	3'UTR	novel		0.2
UCEC	chr1	223799998	Silent	rs138649239	P462P	0.17
UCEC	chr1	223804228	Frame_Shift_Ins	novel	*V199Sfs5**	0.3
UCEC	chr1	223802427	Intron	novel		0.25
UCEC	chr1	223802430	Intron	novel		0.15
UCEC	chr1	223780767	3'UTR	novel		0.22
UCEC	chr1	223792492	Missense_Mutation	novel	G965C	0.32
UCEC	chr1	223810448	Nonsense_Mutation	novel	R119*	0.32
UCEC	chr1	223796438	Missense_Mutation	novel	R701W	0.33
UCEC	chr1	223780884	Missense_Mutation	novel	R1125I	0.43
UCEC	chr1	223802848	Missense_Mutation	novel	Q293H	0.38
UCEC	chr1	223802688	Intron	novel		0.32
UCEC	chr1	223806895	Missense_Mutation	NA	S142Y	0.23
UCEC	chr1	223802321	Silent	novel	P340P	0.24
UCEC	chr1	223798450	Missense_Mutation	novel	D571E	0.23
UCEC	chr1	223798358	Nonsense_Mutation	novel	*P602Lfs15**	0.02
UCEC	chr1	223780796	3'UTR	novel		0.17
UCEC	chr1	223814254	Frame_Shift_Del	NA	*P92Lfs6**	0.23
UCEC	chr1	223802872	Silent	novel	E285E	0.39
UCEC	chr1	223800768	Missense_Mutation	novel	N423T	0.07
UCEC	chr1	223806917	Missense_Mutation	novel	A135T	0.41
UCEC	chr1	223784174	Missense_Mutation	rs199696500	E1102K	0.29
UCEC	chr1	223803375	Nonsense_Mutation	NA	E243*	0.26
UCEC	chr1	223802135	Silent	rs144217750	G402G	0.12
UCEC	chr1	223804343	Missense_Mutation	novel	Q160H	0.39
UCEC	chr1	223821286	Missense_Mutation	rs760385670	V37M	0.53
UCEC	chr1	223795874	Missense_Mutation	rs565603106	G889R	0.31
UCEC	chr1	223818230	Intron	novel		0.14
UCEC	chr1	223784268	Silent	rs760742112	A1070A	0.19
UCEC	chr1	223798268	Missense_Mutation	NA	A632V	0.14
UCEC	chr1	223804222	Missense_Mutation	NA	A201S	0.16
UCEC	chr1	223784161	Missense_Mutation	rs753930874	A1106V	0.33
UCEC	chr1	223814253	Frame_Shift_Ins	novel	*G93Wfs25**	0.32
UCEC	chr1	223780739	3'UTR	novel		0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0833	0.033566
DLBC	DEL	0.125	0.0017831
GBM	DEL	0.0572	0.00056261
KIRC	DEL	0.0663	0.018371
LGG	DEL	0.0351	0.11599
PCPG	DEL	0.0741	0.12617
READ	AMP	0.2667	0.14328
SARC	DEL	0.2957	2.6086e-08
TGCT	DEL	0.0333	0.16985
THYM	AMP	0.1789	0.24554
UCEC	AMP	0.3766	2.3921e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.033	Kaplan-Meier Survival Analysis
SARC	0.0012	Kaplan-Meier Survival Analysis
MESO	0.0083	Kaplan-Meier Survival Analysis
ACC	0.033	Kaplan-Meier Survival Analysis
PCPG	0.015	Kaplan-Meier Survival Analysis
LAML	0.0023	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
UCEC	0.014	Kaplan-Meier Survival Analysis
OV	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000143514 (Gene tree)
Gene ID: 7159
Gene Symbol: TP53BP2
Alias: PPP1R13A|ASPP2|53BP2
Full Name: tumor protein p53 binding protein 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 66,089 bases
Position: chr1:223,779,893-223,845,981
Accession: 12000
Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464656	TP53BP2-204	593	-	ENSP00000417987	64 (aa)	-	H0Y847
ENST00000494100	TP53BP2-212	701	-	ENSP00000420225	234 (aa)	-	H7C5L8
ENST00000473135	TP53BP2-207	567	-	-	- (aa)	-	-
ENST00000465119	TP53BP2-205	465	-	ENSP00000418252	47 (aa)	-	F8WBY9
ENST00000489310	TP53BP2-210	533	-	-	- (aa)	-	-
ENST00000483398	TP53BP2-209	1841	-	ENSP00000417174	64 (aa)	-	H0Y847
ENST00000343537	TP53BP2-201	4651	XM_011544268	ENSP00000341957	1134 (aa)	XP_011542570	Q13625
ENST00000472180	TP53BP2-206	467	-	-	- (aa)	-	-
ENST00000391878	TP53BP2-202	4741	XM_011544269	ENSP00000375750	1005 (aa)	XP_011542571	Q13625
ENST00000481128	TP53BP2-208	631	-	-	- (aa)	-	-
ENST00000464172	TP53BP2-203	537	-	-	- (aa)	-	-
ENST00000496282	TP53BP2-213	481	-	-	- (aa)	-	-
ENST00000498843	TP53BP2-214	2781	-	-	- (aa)	-	-
ENST00000490896	TP53BP2-211	577	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04390	Hippo signaling pathway	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000143514	triptolide	9E-6	26121980
ENSG00000143514	Cell Survival	9E-6	26121980

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143514	rs12723025	1	223789817	?	Triptolide cytotoxicity	26121980	unit increase	0.56	EFO_0007662\|EFO_0006952

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143514's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002039	p53 binding	21873635.	IBA	Function
GO:0002039	p53 binding	14985081.	IPI	Function
GO:0005070	SH3/SH2 adaptor activity	8668206.	TAS	Function
GO:0005515	protein binding	8875926.10498867.10646860.11278849.11684014.12694406.14729977.14985081.15161933.15231748.18275817.18448430.18719108.19377511.21513714.21988832.21998301.22321011.24366813.24855949.25344754.25436413.26496610.28330616.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	19377511.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	10646860.14985081.19377511.	IDA	Component
GO:0005737	cytoplasm	15782125.	TAS	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007049	cell cycle	-	IEA	Process
GO:0007165	signal transduction	9748285.	TAS	Process
GO:0017124	SH3 domain binding	-	IEA	Function
GO:0030054	cell junction	-	IDA	Component
GO:0042802	identical protein binding	18448430.	IPI	Function
GO:0042981	regulation of apoptotic process	-	TAS	Process
GO:0045786	negative regulation of cell cycle	14729977.	TAS	Process
GO:0048471	perinuclear region of cytoplasm	14985081.	IDA	Component
GO:0048471	perinuclear region of cytoplasm	10646860.	IDA	Component
GO:0051059	NF-kappaB binding	10498867.	IPI	Function
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	11684014.	IDA	Process
GO:1900119	positive regulation of execution phase of apoptosis	14985081.	IMP	Process
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	Process
GO:1901216	positive regulation of neuron death	-	IEA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.