EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28220627	Downregulation of miRNA-141 in breast cancer cells is associated with cell migration and invasion: involvement of ANP32E targeting.	Cancer Med	2017 Mar	Li P	doi: 10.1002/cam4.1024

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	150220669	3'UTR	rs782314654		0.13
BLCA	chr1	150231878	Missense_Mutation	novel	E35Q	0.14
BLCA	chr1	150226633	Missense_Mutation	NA	S219L	0.46
BLCA	chr1	150220728	Missense_Mutation	NA	R257Q	0.1
BLCA	chr1	150220747	Nonsense_Mutation	NA	R251*	0.67
BRCA	chr1	150230625	Silent	NA	T91T	0.4
BRCA	chr1	150231805	Missense_Mutation	NA	R59Q	0.14
BRCA	chr1	150229073	Splice_Region	rs151007873	E164E	0.13
BRCA	chr1	150235860	5'UTR	novel		0.29
BRCA	chr1	150231781	Missense_Mutation	rs782603651	R67Q	0.22
CESC	chr1	150230668	Missense_Mutation	NA	S77F	0.27
CESC	chr1	150235749	In_Frame_Ins	novel	N13delinsRERERGRD	0.17
CESC	chr1	150218563	3'UTR	novel		0.34
COAD	chr1	150235860	5'UTR	novel		0.41
COAD	chr1	150220526	3'UTR	novel		0.16
COAD	chr1	150220752	Missense_Mutation	rs143260001	G249D	0.11
COAD	chr1	150229148	Silent	novel	L139L	0.31
COAD	chr1	150235861	5'UTR	novel		0.23
COAD	chr1	150231781	Missense_Mutation	rs782603651	R67Q	0.32
COAD	chr1	150226619	Nonsense_Mutation	NA	E224*	0.07
ESCA	chr1	150220187	3'UTR	novel		0.12
ESCA	chr1	150220138	3'UTR	novel		0.35
ESCA	chr1	150220372	3'UTR	novel		0.24
GBM	chr1	150230599	Missense_Mutation	NA	I100T	0.44
GBM	chr1	150220629	3'UTR	novel		0.83
HNSC	chr1	150229125	Missense_Mutation	novel	G147E	0.24
HNSC	chr1	150230623	Missense_Mutation	novel	Y92S	0.1
HNSC	chr1	150226687	Missense_Mutation	novel	D201G	0.32
HNSC	chr1	150220616	3'UTR	novel		0.35
HNSC	chr1	150230587	Missense_Mutation	novel	S104T	0.1
KIRC	chr1	150220535	3'UTR	novel		0.47
KIRP	chr1	150229224	Missense_Mutation	NA	N114T	0.42
LIHC	chr1	150220603	3'UTR	novel		0.66
LIHC	chr1	150231814	Missense_Mutation	NA	S56L	0.09
LUAD	chr1	150229096	Missense_Mutation	NA	D157Y	0.35
LUAD	chr1	150226746	Silent	NA	P181P	0.27
LUAD	chr1	150235792	5'UTR	rs782751276		0.5
LUSC	chr1	150231919	Missense_Mutation	novel	E21V	0.29
LUSC	chr1	150220746	Missense_Mutation	novel	R251L	0.17
LUSC	chr1	150226724	Missense_Mutation	novel	E189Q	0.22
LUSC	chr1	150220723	Missense_Mutation	novel	A259S	0.17
LUSC	chr1	150226666	Frame_Shift_Ins	novel	*E208Gfs16**	0.05
LUSC	chr1	150226668	Silent	novel	S207S	0.03
LUSC	chr1	150231854	Missense_Mutation	novel	E43Q	0.23
LUSC	chr1	150220642	3'UTR	novel		0.26
OV	chr1	150220599	3'UTR	novel		0.12
OV	chr1	150220619	3'UTR	novel		0.1
READ	chr1	150231781	Missense_Mutation	rs782603651	R67Q	0.26
SARC	chr1	150218607	3'UTR	novel		0.2
SKCM	chr1	150220606	3'UTR	novel		0.38
SKCM	chr1	150226608	Splice_Region	novel	Q227Q	0.65
STAD	chr1	150226792	Missense_Mutation	NA	G166D	0.15
STAD	chr1	150231854	Nonsense_Mutation	NA	E43*	0.27
STAD	chr1	150230694	Splice_Site	novel	X69_splice	0.5
STAD	chr1	150229082	Missense_Mutation	NA	E161D	0.1
STAD	chr1	150229188	Missense_Mutation	NA	T126I	0.42
UCEC	chr1	150231828	Silent	NA	N51N	0.38
UCEC	chr1	150220532	3'UTR	novel		0.45
UCEC	chr1	150231857	Nonsense_Mutation	NA	K42*	0.32
UCEC	chr1	150218535	3'UTR	novel		0.43
UCEC	chr1	150230602	Missense_Mutation	novel	K99T	0.28
UCEC	chr1	150235775	Missense_Mutation	novel	K4N	0.32
UCEC	chr1	150226616	Nonsense_Mutation	NA	E225*	0.46
UCEC	chr1	150231781	Missense_Mutation	rs782603651	R67Q	0.15
UCEC	chr1	150218582	3'UTR	novel		0.4
UCEC	chr1	150223196	Missense_Mutation	novel	E242D	0.43
UCEC	chr1	150218590	3'UTR	novel		0.32
UCEC	chr1	150231781	Missense_Mutation	rs782603651	R67Q	0.06
UCEC	chr1	150235752	Missense_Mutation	NA	R12K	0.25
UCEC	chr1	150235868	5'UTR	novel		0.11
UCEC	chr1	150231842	Missense_Mutation	novel	L47M	0.3
UCEC	chr1	150220116	3'UTR	novel		0.31
UCEC	chr1	150229216	Missense_Mutation	novel	S117R	0.57
UCEC	chr1	150218630	3'UTR	novel		0.21
UCEC	chr1	150220610	3'UTR	novel		0.34
UCEC	chr1	150220516	3'UTR	novel		0.44
UCEC	chr1	150218544	3'UTR	novel		0.23
UCEC	chr1	150220268	3'UTR	novel		0.46
UCEC	chr1	150220152	3'UTR	novel		0.25
UCEC	chr1	150229149	Missense_Mutation	novel	L139P	0.21
UCEC	chr1	150218544	3'UTR	novel		0.22
UCEC	chr1	150220382	3'UTR	novel		0.31
UCEC	chr1	150220706	Missense_Mutation	novel	E264D	0.43
UCEC	chr1	150235850	5'UTR	novel		0.48
UCEC	chr1	150235776	Missense_Mutation	rs782000338	K4M	0.31
UCEC	chr1	150220502	3'UTR	novel		0.29
UCEC	chr1	150230582	Missense_Mutation	novel	V106L	0.39
UCEC	chr1	150223217	Nonsense_Mutation	novel	Y235*	0.68
UCEC	chr1	150218428	3'UTR	novel		0.4
UCEC	chr1	150220728	Missense_Mutation	NA	R257Q	0.19
UCEC	chr1	150220753	Missense_Mutation	novel	G249C	0.21
UCS	chr1	150220762	Splice_Site	novel	X246_splice	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1556	0.11282
CESC	AMP	0.4746	3.2002e-05
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3967	0.0022446
KIRC	AMP	0.0928	0.059566
LUSC	AMP	0.4271	1.6618e-06
PAAD	AMP	0.2174	0.085665
PCPG	AMP	0.1543	0.00029562
READ	AMP	0.2606	0.025154
SARC	AMP	0.3307	4.3422e-08
SKCM	AMP	0.4741	9.6912e-06
STAD	AMP	0.254	1.12e-06
TGCT	AMP	0.3533	0.088103

Survival Analysis

Cancer	P-value	Q-value
THYM	0.011	Kaplan-Meier Survival Analysis
STAD	0.047	Kaplan-Meier Survival Analysis
SARC	0.00043	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
SKCM	0.023	Kaplan-Meier Survival Analysis
LUSC	0.015	Kaplan-Meier Survival Analysis
KIRP	0.00029	Kaplan-Meier Survival Analysis
PAAD	0.0076	Kaplan-Meier Survival Analysis
LAML	0.016	Kaplan-Meier Survival Analysis
GBM	0.039	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LGG	0.00088	Kaplan-Meier Survival Analysis
LUAD	0.0026	Kaplan-Meier Survival Analysis
UVM	0.022	Kaplan-Meier Survival Analysis
OV	0.048	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000143401 (Gene tree)
Gene ID: 81611
Gene Symbol: ANP32E
Alias: LANPL|MGC5350|LANP-L
Full Name: acidic nuclear phosphoprotein 32 family member E
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 17,740 bases
Position: chr1:150,218,417-150,236,156
Accession: 16673
Summary: (Acidic Nuclear Phosphoprotein 32 Family Member E) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include histone binding and phosphatase inhibitor activity. An important paralog of this gene is ANP32A.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000533654	ANP32E-205	908	-	ENSP00000435215	165 (aa)	-	E9PLC4
ENST00000629042	ANP32E-210	3054	-	ENSP00000487027	136 (aa)	-	Q5TB25
ENST00000534220	ANP32E-206	512	-	ENSP00000436529	105 (aa)	-	E9PI45
ENST00000534437	ANP32E-207	616	-	ENSP00000431434	100 (aa)	-	H0YCE2
ENST00000616917	ANP32E-209	2989	-	ENSP00000481415	220 (aa)	-	Q9BTT0
ENST00000369115	ANP32E-202	708	-	ENSP00000358111	136 (aa)	-	Q5TB25
ENST00000369114	ANP32E-201	1048	-	ENSP00000358110	149 (aa)	-	Q5TB19
ENST00000532744	ANP32E-204	621	-	ENSP00000432684	114 (aa)	-	E9PPH5
ENST00000583931	ANP32E-208	3451	XM_005245513	ENSP00000463154	268 (aa)	XP_005245570	Q9BTT0
ENST00000436748	ANP32E-203	1339	-	ENSP00000393718	227 (aa)	-	Q9BTT0

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000143401	Circadian Rhythm	5E-6	26835600

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143401	rs10888576	1	150228460	?	Morning vs. evening chronotype	26835600			EFO_0004354

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143401's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143401	ANP32E	97	50.932	ENSG00000140350	ANP32A	86	71.053	Homo_sapiens
ENSG00000143401	ANP32E	96	47.799	ENSG00000136938	ANP32B	61	66.447	Homo_sapiens
ENSG00000143401	ANP32E	84	98.958	ENSMUSG00000015749	Anp32e	100	100.000	Mus_musculus
ENSG00000143401	ANP32E	97	46.875	ENSMUSG00000028333	Anp32b	56	61.842	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000812	Swr1 complex	24463511.	IDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0019212	phosphatase inhibitor activity	21873635.	IBA	Function
GO:0019212	phosphatase inhibitor activity	-	ISS	Function
GO:0031410	cytoplasmic vesicle	-	ISS	Component
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042393	histone binding	24463511.	IDA	Function
GO:0043086	negative regulation of catalytic activity	-	IEA	Process
GO:0043486	histone exchange	21873635.	IBA	Process
GO:0043486	histone exchange	24463511.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.