EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25404354	SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway.	J Pathol	2015 Mar	Sun QY	doi: 10.1002/path.4482
30309377	Knockdown of SETDB1 inhibits breast cancer progression by miR-381-3p-related regulation.	Biol Res	2018 Oct 11	Wu M	doi: 10.1186/s40659-018-0189-0.
26471002	Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53.	Nat Commun	2015 Oct 16	Fei Q	doi: 10.1038/ncomms9651.
25477335	H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis.	Cancer Res	2014 Dec 15	Wu PC	doi: 10.1158/0008-5472.CAN-13-3572
26846621	Quantitative proteomic study of human prostate cancer cells with different metastatic potentials.	Int J Oncol	2016 Apr	Li Q	doi: 10.3892/ijo.2016.3378
23770855	Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis.	Oncogene	2014 May 22	Rodriguez-Paredes M	doi: 10.1038/onc.2013.239
25070049	MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.	Stem Cells	2014 Nov	Zhang H	doi: 10.1002/stem.1795.
16682412	The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.	J Biol Chem	2006 Jul 14	Li H	-
26840455	Setdb1, a novel interactor of ?Np63, is involved in breast tumorigenesis.	Oncotarget	2016 May 17	Regina C	doi: 10.18632/oncotarget.7089.
30105513	Prognostic value of histone marks H3K27me3 and H3K9me3 and modifying enzymes EZH2, SETDB1 and LSD-1 in colorectal cancer.	J Cancer Res Clin Oncol	2018 Nov	Carvalho S	doi: 10.1007/s00432-018-2733-2

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	150929992	Missense_Mutation	novel	V96L	0.2
BLCA	chr1	150961017	Silent	novel	L985L	0.19
BLCA	chr1	150961126	Missense_Mutation	novel	E1022K	0.21
BLCA	chr1	150960985	Missense_Mutation	novel	E975Q	0.2
BLCA	chr1	150950963	Missense_Mutation	NA	E696K	0.06
BLCA	chr1	150960730	Missense_Mutation	novel	D890H	0.09
BLCA	chr1	150960996	Silent	novel	K978K	0.04
BLCA	chr1	150950552	Missense_Mutation	NA	P559S	0.13
BLCA	chr1	150950895	Missense_Mutation	rs777467787	Y673C	0.29
BLCA	chr1	150960963	Silent	novel	G967G	0.49
BLCA	chr1	150964314	Missense_Mutation	NA	E1276Q	0.13
BLCA	chr1	150964244	Splice_Region	novel		0.4
BLCA	chr1	150950963	Missense_Mutation	NA	E696Q	0.21
BLCA	chr1	150927793	Nonsense_Mutation	novel	Q27*	0.09
BLCA	chr1	150949478	Silent	novel	L511L	0.05
BLCA	chr1	150946973	Missense_Mutation	novel	E410Q	0.22
BLCA	chr1	150949430	Silent	novel	R495R	0.34
BLCA	chr1	150960810	Silent	novel	F916F	0.07
BLCA	chr1	150963118	Missense_Mutation	novel	E1146Q	0.19
BLCA	chr1	150950737	Silent	novel	K620K	0.18
BLCA	chr1	150960760	Nonsense_Mutation	NA	E900*	0.44
BLCA	chr1	150949129	Silent	novel	V425V	0.34
BRCA	chr1	150964252	Missense_Mutation	novel	I1255S	0.3
BRCA	chr1	150927915	Missense_Mutation	novel	W67C	0.09
BRCA	chr1	150960675	Missense_Mutation	NA	E871D	0.11
BRCA	chr1	150963013	Nonsense_Mutation	novel	E1111*	0.09
BRCA	chr1	150943936	Missense_Mutation	novel	D298Y	0.2
BRCA	chr1	150964048	Silent	novel	D1241D	0.07
BRCA	chr1	150960598	Missense_Mutation	NA	G846C	0.15
BRCA	chr1	150951439	Missense_Mutation	NA	S763C	0.23
BRCA	chr1	150959190	Frame_Shift_Ins	NA	*N782Kfs7**	0.42
BRCA	chr1	150962604	Missense_Mutation	rs751371356	R1059Q	0.15
BRCA	chr1	150949399	Missense_Mutation	NA	K485T	0.2
BRCA	chr1	150963001	Missense_Mutation	NA	E1107Q	0.25
BRCA	chr1	150950815	Silent	NA	F646F	0.11
BRCA	chr1	150964547	3'UTR	novel		0.11
BRCA	chr1	150961182	Nonsense_Mutation	novel	*K1041Ffs2**	0.2
BRCA	chr1	150951439	Missense_Mutation	NA	S763F	0.1
BRCA	chr1	150946942	Silent	novel	F399F	0.06
BRCA	chr1	150949438	Missense_Mutation	NA	S498Y	0.21
CESC	chr1	150964305	Missense_Mutation	NA	E1273Q	0.33
CESC	chr1	150961017	Missense_Mutation	novel	L985F	0.09
CESC	chr1	150941374	Missense_Mutation	NA	Q165E	0.25
CESC	chr1	150930028	Missense_Mutation	rs751646362	R108W	0.35
CESC	chr1	150945139	Intron	NA		0.12
CESC	chr1	150945093	Silent	rs765231930	V375V	0.39
CESC	chr1	150963703	Missense_Mutation	novel	D1211H	0.06
CESC	chr1	150963109	Missense_Mutation	NA	D1143Y	0.29
COAD	chr1	150949172	Missense_Mutation	NA	G440S	0.39
COAD	chr1	150945148	Intron	rs587715611		0.32
COAD	chr1	150963642	Silent	rs759554112	S1190S	0.41
COAD	chr1	150945265	Intron	novel		0.21
COAD	chr1	150962651	Missense_Mutation	rs145309946	R1075C	0.14
COAD	chr1	150963757	Intron	novel		0.22
COAD	chr1	150941389	Missense_Mutation	novel	A170S	0.04
COAD	chr1	150960829	Missense_Mutation	NA	R923W	0.32
COAD	chr1	150946985	Nonsense_Mutation	novel	G414*	0.07
COAD	chr1	150959198	Missense_Mutation	novel	R784H	0.2
COAD	chr1	150960890	Missense_Mutation	novel	T943I	0.28
COAD	chr1	150945150	Intron	novel		0.35
COAD	chr1	150964254	Missense_Mutation	NA	R1256W	0.2
COAD	chr1	150950923	Silent	NA	I682I	0.39
COAD	chr1	150963653	Missense_Mutation	rs750158928	R1194H	0.4
COAD	chr1	150949171	Silent	rs777376952	T439T	0.1
COAD	chr1	150963528	Splice_Site	NA	X1153_splice	0.48
COAD	chr1	150942947	Missense_Mutation	novel	K257E	0.21
COAD	chr1	150951084	Missense_Mutation	rs200603147	R736Q	0.44
COAD	chr1	150927928	Nonsense_Mutation	NA	E72*	0.39
COAD	chr1	150939962	Frame_Shift_Del	novel	*D147Tfs11**	0.26
COAD	chr1	150944957	Missense_Mutation	rs200241875	R330H	0.33
COAD	chr1	150964255	Missense_Mutation	NA	R1256Q	0.31
COAD	chr1	150950705	Missense_Mutation	NA	R610W	0.28	MBD
COAD	chr1	150950720	Missense_Mutation	novel	R615C	0.31	MBD
COAD	chr1	150960593	Missense_Mutation	novel	K844R	0.38
COAD	chr1	150944996	Missense_Mutation	NA	R343H	0.15
ESCA	chr1	150945064	Nonsense_Mutation	novel	R366*	0.16
ESCA	chr1	150959280	Silent	novel	Q811Q	0.33
ESCA	chr1	150963742	Splice_Site	rs111660370	X1223_splice	0.2
ESCA	chr1	150951455	Silent	novel	K768K	0.14
ESCA	chr1	150964289	Silent	rs770434872	Y1267Y	0.35
GBM	chr1	150964254	Missense_Mutation	NA	R1256W	0.34
GBM	chr1	150960798	Silent	novel	K912K	0.11
GBM	chr1	150963658	Missense_Mutation	novel	N1196D	0.08
GBM	chr1	150964253	Silent	novel	I1255I	0.26
GBM	chr1	150962681	Missense_Mutation	novel	S1085R	0.2
GBM	chr1	150960965	Missense_Mutation	novel	C968S	0.03
GBM	chr1	150964282	Missense_Mutation	novel	Y1265S	0.12
HNSC	chr1	150963595	Missense_Mutation	novel	I1175V	0.2
HNSC	chr1	150927777	Silent	novel	E21E	0.15
HNSC	chr1	150963090	Missense_Mutation	novel	I1136M	0.23
HNSC	chr1	150962139	Missense_Mutation	novel	D1047N	0.28
HNSC	chr1	150950692	Silent	rs758639919	L605L	0.49
HNSC	chr1	150950963	Missense_Mutation	NA	E696K	0.25
HNSC	chr1	150942995	Missense_Mutation	novel	Q273E	0.22
HNSC	chr1	150960712	Missense_Mutation	rs776369381	D884Y	0.3
HNSC	chr1	150950918	Missense_Mutation	novel	D681N	0.15
KIRC	chr1	150945239	Intron	novel		0.18
KIRC	chr1	150950954	Missense_Mutation	NA	C693R	0.31
KIRP	chr1	150964314	Missense_Mutation	NA	E1276K	0.26
KIRP	chr1	150927863	In_Frame_Del	novel	K50_C53delinsS	0.31
KIRP	chr1	150950458	Missense_Mutation	novel	R527S	0.42
KIRP	chr1	150963615	Missense_Mutation	novel	N1181K	0.08
LAML	chr1	150963677	Missense_Mutation	novel	D1202V	0.02
LGG	chr1	150963742	Splice_Site	rs111660370	X1223_splice	0.43
LGG	chr1	150950472	In_Frame_Del	novel	T533del	0.04
LGG	chr1	150943955	Missense_Mutation	NA	Y304C	0.35
LIHC	chr1	150942988	Silent	NA	D270D	0.09
LIHC	chr1	150964027	Missense_Mutation	novel	N1234K	0.42
LIHC	chr1	150960947	Nonsense_Mutation	NA	S962*	0.07
LIHC	chr1	150927801	Silent	NA	V29V	0.08
LUAD	chr1	150949250	Missense_Mutation	novel	P466S	0.31
LUAD	chr1	150941394	Silent	novel	V171V	0.24
LUAD	chr1	150945171	Intron	novel		0.17
LUAD	chr1	150950858	Missense_Mutation	novel	D661Y	0.16
LUAD	chr1	150950859	Missense_Mutation	novel	D661V	0.15
LUAD	chr1	150950455	Splice_Region	novel		0.19
LUAD	chr1	150963655	Nonsense_Mutation	novel	K1195*	0.1
LUAD	chr1	150942664	Frame_Shift_Ins	novel	*L218Pfs18**	0.24
LUAD	chr1	150960881	Missense_Mutation	novel	S940F	0.1
LUAD	chr1	150943964	Missense_Mutation	NA	Q307L	0.11
LUAD	chr1	150960975	Silent	NA	P971P	0.1
LUAD	chr1	150960760	Nonsense_Mutation	NA	E900*	0.38
LUAD	chr1	150963046	Missense_Mutation	NA	Q1122E	0.39
LUAD	chr1	150950881	Silent	novel	R668R	0.09
LUSC	chr1	150959258	Missense_Mutation	novel	R804L	0.47
LUSC	chr1	150959219	Missense_Mutation	novel	M791T	0.29
LUSC	chr1	150962614	Silent	novel	G1062G	0.41
LUSC	chr1	150963689	Missense_Mutation	novel	S1206Y	0.15
LUSC	chr1	150942679	Missense_Mutation	novel	Q222K	0.22
LUSC	chr1	150944943	Missense_Mutation	novel	E325D	0.43
LUSC	chr1	150927813	Silent	NA	L33L	0.36
LUSC	chr1	150963637	Missense_Mutation	NA	E1189Q	0.09
LUSC	chr1	150946971	Missense_Mutation	NA	L409P	0.31
LUSC	chr1	150960925	Missense_Mutation	novel	P955S	0.08
LUSC	chr1	150959309	Missense_Mutation	NA	D821G	0.39
MESO	chr1	150950897	Frame_Shift_Del	NA	*K674Sfs73**	0.6
MESO	chr1	150962601	Frame_Shift_Ins	novel	*R1059Sfs13**	0.57
MESO	chr1	150950879	Nonsense_Mutation	novel	R668*	0.64
OV	chr1	150942630	Silent	NA	L205L	0.45
OV	chr1	150960998	Missense_Mutation	novel	N979I	0.11
OV	chr1	150949456	Missense_Mutation	NA	S504C	0.28
OV	chr1	150950967	Missense_Mutation	NA	I697T	0.12
OV	chr1	150941402	In_Frame_Del	novel	S175_Q178del	0.05
OV	chr1	150942623	Missense_Mutation	rs371182642	R203Q	0.44
OV	chr1	150964549	3'UTR	novel		0.19
OV	chr1	150945256	Intron	novel		0.25
OV	chr1	150950765	Missense_Mutation	novel	P630A	0.03	MBD
OV	chr1	150964052	Missense_Mutation	NA	R1243C	0.04
OV	chr1	150951468	In_Frame_Ins	novel	C773delinsSACPVTEAGS	0.4
PAAD	chr1	150949393	Nonsense_Mutation	novel	S483*	0.13
PAAD	chr1	150942562	Splice_Site	novel	X183_splice	0.07
PRAD	chr1	150950598	Frame_Shift_Ins	novel	*P575Tfs18**	0.29
PRAD	chr1	150963642	Silent	rs759554112	S1190S	0.37
READ	chr1	150942622	Nonsense_Mutation	NA	R203*	0.13
READ	chr1	150949521	Missense_Mutation	NA	Y526H	0.36
READ	chr1	150959257	Missense_Mutation	NA	R804W	0.43
SARC	chr1	150951085	Silent	novel	R736R	0.12
SARC	chr1	150930012	Missense_Mutation	novel	K102N	0.07
SARC	chr1	150960740	Missense_Mutation	novel	S893I	0.06
SARC	chr1	150960860	Missense_Mutation	novel	G933V	0.08
SARC	chr1	150945151	Intron	novel		0.37
SARC	chr1	150950833	Silent	rs758794776	F652F	0.32
SKCM	chr1	150960802	Nonsense_Mutation	novel	E914*	0.19
SKCM	chr1	150950880	Missense_Mutation	rs199613890	R668Q	0.26
SKCM	chr1	150960736	Missense_Mutation	NA	N892D	0.55
SKCM	chr1	150950783	Missense_Mutation	NA	R636W	0.21
SKCM	chr1	150944924	Missense_Mutation	NA	K319M	0.26
SKCM	chr1	150943006	Silent	novel	L276L	0.48
SKCM	chr1	150949262	Nonsense_Mutation	NA	Q470*	0.12
SKCM	chr1	150949257	Missense_Mutation	novel	S468F	0.36
SKCM	chr1	150930039	Silent	NA	S111S	0.46
SKCM	chr1	150930053	Missense_Mutation	NA	S116F	0.17
SKCM	chr1	150960859	Missense_Mutation	novel	G933S	0.89
SKCM	chr1	150949262	Nonsense_Mutation	NA	Q470*	0.59
SKCM	chr1	150927722	Missense_Mutation	rs761509888	S3F	0.35
SKCM	chr1	150961122	Silent	novel	E1020E	0.08
SKCM	chr1	150949173	Missense_Mutation	novel	G440D	0.21
SKCM	chr1	150963635	Missense_Mutation	novel	G1188E	0.44
SKCM	chr1	150930102	Silent	novel	V132V	0.39
STAD	chr1	150949171	Silent	rs777376952	T439T	0.08
STAD	chr1	150950730	Missense_Mutation	NA	N618S	0.34	MBD
STAD	chr1	150950706	Missense_Mutation	NA	R610Q	0.22	MBD
STAD	chr1	150930011	Missense_Mutation	NA	K102T	0.58
STAD	chr1	150943047	Missense_Mutation	NA	K290T	0.31
STAD	chr1	150961114	Nonsense_Mutation	novel	R1018*	0.23
STAD	chr1	150950783	Missense_Mutation	NA	R636W	0.26
STAD	chr1	150959293	Missense_Mutation	NA	G816C	0.33
STAD	chr1	150964053	Missense_Mutation	NA	R1243H	0.11
STAD	chr1	150945148	Intron	rs587715611		0.42
STAD	chr1	150964047	Missense_Mutation	NA	D1241G	0.31
STAD	chr1	150942591	Silent	novel	L192L	0.06
STAD	chr1	150963558	Missense_Mutation	NA	K1162N	0.04
STAD	chr1	150941354	Missense_Mutation	novel	R158K	0.49
STAD	chr1	150964254	Missense_Mutation	NA	R1256W	0.4
STAD	chr1	150960981	Silent	rs587757597	S973S	0.74
STAD	chr1	150950571	Missense_Mutation	NA	R565H	0.27
STAD	chr1	150960906	Frame_Shift_Del	NA	*P950Qfs16**	0.35
STAD	chr1	150942921	Missense_Mutation	NA	A248V	0.12
STAD	chr1	150960845	Missense_Mutation	NA	R928Q	0.06
STAD	chr1	150927884	Missense_Mutation	rs767529609	R57H	0.12
STAD	chr1	150927885	Silent	novel	R57R	0.12
STAD	chr1	150959192	Missense_Mutation	NA	N782S	0.06
STAD	chr1	150961006	Missense_Mutation	rs760913907	A982T	0.18
STAD	chr1	150949171	Silent	rs777376952	T439T	0.67
THCA	chr1	150963682	Missense_Mutation	NA	E1204K	0.47
UCEC	chr1	150927794	Missense_Mutation	NA	Q27R	0.31
UCEC	chr1	150945162	Intron	NA		0.18
UCEC	chr1	150944978	Missense_Mutation	novel	V337A	0.16
UCEC	chr1	150949419	Missense_Mutation	NA	T492A	0.37
UCEC	chr1	150944968	Nonsense_Mutation	novel	E334*	0.04
UCEC	chr1	150951070	Silent	NA	C731C	0.31
UCEC	chr1	150950498	Missense_Mutation	novel	A541S	0.2
UCEC	chr1	150963652	Missense_Mutation	rs764341148	R1194C	0.35
UCEC	chr1	150964486	3'UTR	novel		0.33
UCEC	chr1	150943944	Silent	novel	G300G	0.42
UCEC	chr1	150945200	Intron	novel		0.45
UCEC	chr1	150942663	Silent	novel	G216G	0.24
UCEC	chr1	150951008	Missense_Mutation	novel	R711C	0.33
UCEC	chr1	150960873	Silent	rs587615660	N937N	0.41
UCEC	chr1	150962611	Silent	rs374865769	Y1061Y	0.12
UCEC	chr1	150963570	Silent	novel	G1166G	0.33
UCEC	chr1	150962980	Missense_Mutation	novel	L1100M	0.23
UCEC	chr1	150950658	Missense_Mutation	novel	Y594C	0.28
UCEC	chr1	150959323	Missense_Mutation	novel	G826S	0.42
UCEC	chr1	150963571	Missense_Mutation	novel	F1167V	0.21
UCEC	chr1	150964020	Missense_Mutation	NA	V1232G	0.44
UCEC	chr1	150960963	Silent	NA	G967G	0.29
UCEC	chr1	150964053	Missense_Mutation	NA	R1243H	0.27
UCEC	chr1	150950719	Silent	NA	R614R	0.34
UCEC	chr1	150927957	Silent	NA	L81L	0.15
UCEC	chr1	150962648	Missense_Mutation	rs147846533	R1074C	0.39
UCEC	chr1	150942622	Nonsense_Mutation	NA	R203*	0.49
UCEC	chr1	150963623	Missense_Mutation	novel	S1184Y	0.38
UCEC	chr1	150962604	Missense_Mutation	rs751371356	R1059Q	0.33
UCEC	chr1	150963837	Intron	novel		0.46
UCEC	chr1	150950901	Frame_Shift_Ins	novel	*Y677Lfs20**	0.27
UCEC	chr1	150963642	Silent	rs759554112	S1190S	0.35
UCEC	chr1	150964033	Silent	rs746153161	F1236F	0.57
UCEC	chr1	150959257	Missense_Mutation	NA	R804W	0.47
UCEC	chr1	150942622	Nonsense_Mutation	NA	R203*	0.46
UCEC	chr1	150941332	Missense_Mutation	NA	R151C	0.08
UCEC	chr1	150927927	Missense_Mutation	novel	K71N	0.28
UCEC	chr1	150927928	Missense_Mutation	novel	E72K	0.28
UCEC	chr1	150960666	Missense_Mutation	NA	E868D	0.29
UCEC	chr1	150949428	Nonsense_Mutation	NA	R495*	0.44
UCEC	chr1	150951001	Missense_Mutation	novel	S708R	0.35
UCEC	chr1	150927770	Missense_Mutation	rs200557606	S19F	0.33
UCEC	chr1	150949438	Missense_Mutation	NA	S498Y	0.45
UCEC	chr1	150963608	Missense_Mutation	NA	S1179L	0.28
UCEC	chr1	150960611	Missense_Mutation	NA	G850D	0.57
UCEC	chr1	150945290	Intron	novel		0.33
UCEC	chr1	150963665	Missense_Mutation	novel	R1198H	0.49
UCEC	chr1	150961094	Missense_Mutation	novel	E1011G	0.31
UCEC	chr1	150963731	Missense_Mutation	novel	R1220H	0.18
UCEC	chr1	150950479	Silent	novel	A534A	0.39
UCEC	chr1	150950880	Missense_Mutation	rs199613890	R668Q	0.38
UCEC	chr1	150960777	Missense_Mutation	novel	S905R	0.33
UCEC	chr1	150949420	Missense_Mutation	novel	T492M	0.28
UCEC	chr1	150960683	Missense_Mutation	novel	A874V	0.17
UCEC	chr1	150964052	Missense_Mutation	NA	R1243C	0.31
UCEC	chr1	150950861	Missense_Mutation	novel	P662S	0.22
UCEC	chr1	150964309	Missense_Mutation	novel	G1274D	0.32
UCEC	chr1	150962138	Silent	rs141513295	D1046D	0.03
UCEC	chr1	150927847	Missense_Mutation	novel	D45N	0.14
UCEC	chr1	150959315	Missense_Mutation	novel	I823N	0.27
UCEC	chr1	150963681	Silent	NA	G1203G	0.17
UCEC	chr1	150945147	Intron	rs755041728		0.44
UCEC	chr1	150927814	Missense_Mutation	novel	G34C	0.2
UCEC	chr1	150964313	Missense_Mutation	novel	K1275N	0.14
UCEC	chr1	150960906	Frame_Shift_Del	NA	*P950Qfs16**	0.33
UCEC	chr1	150930057	Silent	novel	S117S	0.22
UCEC	chr1	150942949	Missense_Mutation	novel	K257N	0.18
UCEC	chr1	150950815	Silent	NA	F646F	0.07
UCEC	chr1	150959318	Missense_Mutation	NA	A824V	0.3
UCEC	chr1	150945261	Intron	novel		0.25
UCEC	chr1	150950815	Silent	NA	F646F	0.36
UCEC	chr1	150962604	Missense_Mutation	rs751371356	R1059Q	0.23
UCEC	chr1	150963837	Intron	novel		0.42
UCEC	chr1	150960906	Frame_Shift_Del	NA	*P950Qfs16**	0.32
UCEC	chr1	150945239	Intron	novel		0.1
UCEC	chr1	150945240	Intron	novel		0.01
UCEC	chr1	150950737	Silent	novel	K620K	0.04
UCEC	chr1	150960913	Missense_Mutation	novel	D951N	0.17
UCEC	chr1	150962642	Nonsense_Mutation	NA	G1072*	0.23
UCEC	chr1	150964289	Silent	rs770434872	Y1267Y	0.2
UCEC	chr1	150945239	Intron	novel		0.07
UCEC	chr1	150949258	Silent	novel	S468S	0.38
UCEC	chr1	150929974	Missense_Mutation	NA	T90A	0.17
UCEC	chr1	150946934	Missense_Mutation	novel	P397A	0.09
UCEC	chr1	150964289	Silent	rs770434872	Y1267Y	0.18
UCEC	chr1	150930072	Missense_Mutation	novel	I122M	0.4
UCEC	chr1	150941423	Missense_Mutation	novel	H181R	0.5
UCEC	chr1	150951009	Missense_Mutation	novel	R711H	0.17
UCEC	chr1	150927846	Silent	rs144818367	I44I	0.28
UCEC	chr1	150950900	Missense_Mutation	novel	P675S	0.33
UCS	chr1	150960857	Missense_Mutation	rs773137921	R932Q	0.38
UCS	chr1	150960704	Frame_Shift_Del	novel	*S881Rfs18**	0.4
UCS	chr1	150949522	Missense_Mutation	novel	Y526C	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1333	0.11282
CESC	AMP	0.4814	3.2002e-05
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3913	0.0022446
KIRC	AMP	0.0928	0.059566
LUAD	AMP	0.624	2.2264e-28
LUSC	AMP	0.4271	1.6618e-06
PAAD	AMP	0.2174	0.085665
PCPG	AMP	0.1481	0.00029562
READ	AMP	0.2667	0.025154
SARC	AMP	0.3424	4.3422e-08
SKCM	AMP	0.485	9.6912e-06
STAD	AMP	0.2653	1.12e-06
TGCT	AMP	0.3467	0.088103
UCEC	AMP	0.4286	3.1683e-22

Survival Analysis

Cancer	P-value	Q-value
ACC	0.00016	Kaplan-Meier Survival Analysis
KIRP	0.019	Kaplan-Meier Survival Analysis
PCPG	0.038	Kaplan-Meier Survival Analysis
LAML	0.01	Kaplan-Meier Survival Analysis
KICH	0.044	Kaplan-Meier Survival Analysis
UCEC	0.0061	Kaplan-Meier Survival Analysis
GBM	0.05	Kaplan-Meier Survival Analysis
LIHC	0.0014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000143379 (Gene tree)
Gene ID: 9869
Gene Symbol: SETDB1
Alias: KG1T|KIAA0067|ESET|KMT1E|TDRD21
Full Name: SET domain bifurcated histone lysine methyltransferase 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 38,639 bases
Position: chr1:150,926,263-150,964,901
Accession: 10761
Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000432348	MBD	PF01429.19	5.3e-12	1	1
ENSP00000271640	MBD	PF01429.19	5.4e-12	1	1
ENSP00000357965	MBD	PF01429.19	5.4e-12	1	1
ENSP00000436148	MBD	PF01429.19	0.00022	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20615470	Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies.	Methods	2011 Jan	Pagans S	doi: 10.1016/j.ymeth.2010.07.001
25512341	The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.	Cell Res	2015 Jan	Bao X	doi: 10.1038/cr.2014.165

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000528749	SETDB1-215	527	-	-	- (aa)	-	-
ENST00000498193	SETDB1-213	3854	-	ENSP00000432348	1259 (aa)	-	E9PRF4
ENST00000368964	SETDB1-204	548	-	ENSP00000357960	111 (aa)	-	E9PAP1
ENST00000448029	SETDB1-207	668	-	ENSP00000409379	156 (aa)	-	B0QZE6
ENST00000368962	SETDB1-202	1478	XM_017002955	ENSP00000357958	397 (aa)	XP_016858444	Q15047
ENST00000533529	SETDB1-216	485	-	-	- (aa)	-	-
ENST00000463774	SETDB1-209	570	-	-	- (aa)	-	-
ENST00000368969	SETDB1-205	4370	-	ENSP00000357965	1290 (aa)	-	Q15047
ENST00000271640	SETDB1-201	4437	XM_005245641	ENSP00000271640	1291 (aa)	XP_005245698	Q15047
ENST00000423081	SETDB1-206	590	-	ENSP00000407831	150 (aa)	-	X6RHV1
ENST00000459773	SETDB1-208	791	-	-	- (aa)	-	-
ENST00000497314	SETDB1-212	2321	-	-	- (aa)	-	-
ENST00000481219	SETDB1-210	623	-	-	- (aa)	-	-
ENST00000368963	SETDB1-203	1045	-	ENSP00000357959	249 (aa)	-	X6R732
ENST00000487584	SETDB1-211	558	-	-	- (aa)	-	-
ENST00000534805	SETDB1-217	2043	-	ENSP00000436148	636 (aa)	-	E9PQM8
ENST00000525956	SETDB1-214	587	-	ENSP00000435922	163 (aa)	-	E9PS59

Gene Model

Click here to download ENSG00000143379's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG
hsa04550	Signaling pathways regulating pluripotency of stem cells	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143379	rs148634917	1	150943746	G	Interleukin-5 levels	27989323	[0.29-0.72] SD units increase	0.5052	EFO_0008185
ENSG00000143379	rs35486314	1	150929386	AT	Monocyte chemoattractant protein-1 levels	27989323	[0.048-0.11] SD units increase	0.0791	EFO_0004749

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143379's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143379	SETDB1	91	55.838	ENSAPOG00000016228	setdb1b	99	68.280	Acanthochromis_polyacanthus
ENSG00000143379	SETDB1	100	96.000	ENSAMEG00000001160	SETDB1	100	96.000	Ailuropoda_melanoleuca
ENSG00000143379	SETDB1	92	70.109	ENSACIG00000007359	setdb1b	99	70.109	Amphilophus_citrinellus
ENSG00000143379	SETDB1	97	52.167	ENSAOCG00000005586	setdb1b	56	68.722	Amphiprion_ocellaris
ENSG00000143379	SETDB1	93	55.291	ENSAPEG00000007774	setdb1b	55	68.282	Amphiprion_percula
ENSG00000143379	SETDB1	92	62.557	ENSATEG00000023520	setdb1b	99	69.355	Anabas_testudineus
ENSG00000143379	SETDB1	99	76.583	ENSAPLG00000013908	SETDB1	100	76.183	Anas_platyrhynchos
ENSG00000143379	SETDB1	100	99.058	ENSANAG00000001819	SETDB1	100	98.840	Aotus_nancymaae
ENSG00000143379	SETDB1	99	57.755	ENSACLG00000020489	setdb1b	98	70.270	Astatotilapia_calliptera
ENSG00000143379	SETDB1	84	67.000	ENSAMXG00000016168	setdb1b	81	74.286	Astyanax_mexicanus
ENSG00000143379	SETDB1	84	44.444	ENSAMXG00000010030	setdb1a	67	66.165	Astyanax_mexicanus
ENSG00000143379	SETDB1	100	96.365	ENSBTAG00000000098	SETDB1	100	96.365	Bos_taurus
ENSG00000143379	SETDB1	100	98.380	ENSCJAG00000006972	SETDB1	100	98.380	Callithrix_jacchus
ENSG00000143379	SETDB1	100	98.160	ENSCAFG00000023501	SETDB1	100	96.448	Canis_familiaris
ENSG00000143379	SETDB1	100	98.160	ENSCAFG00020013596	SETDB1	100	96.373	Canis_lupus_dingo
ENSG00000143379	SETDB1	100	96.365	ENSCHIG00000010698	SETDB1	100	96.365	Capra_hircus
ENSG00000143379	SETDB1	100	95.092	ENSTSYG00000012646	SETDB1	100	95.594	Carlito_syrichta
ENSG00000143379	SETDB1	79	92.857	ENSCAPG00000013619	SETDB1	100	92.857	Cavia_aperea
ENSG00000143379	SETDB1	100	95.706	ENSCPOG00000001632	SETDB1	100	95.128	Cavia_porcellus
ENSG00000143379	SETDB1	100	98.842	ENSCCAG00000024882	SETDB1	100	98.842	Cebus_capucinus
ENSG00000143379	SETDB1	100	95.588	ENSCATG00000044888	SETDB1	100	95.588	Cercocebus_atys
ENSG00000143379	SETDB1	100	95.092	ENSCLAG00000000242	SETDB1	100	95.227	Chinchilla_lanigera
ENSG00000143379	SETDB1	88	99.298	ENSCSAG00000018034	SETDB1	100	99.298	Chlorocebus_sabaeus
ENSG00000143379	SETDB1	100	90.798	ENSCHOG00000004013	SETDB1	100	85.913	Choloepus_hoffmanni
ENSG00000143379	SETDB1	99	78.899	ENSCPBG00000008716	SETDB1	100	78.380	Chrysemys_picta_bellii
ENSG00000143379	SETDB1	99	95.190	ENSCANG00000036388	SETDB1	98	96.819	Colobus_angolensis_palliatus
ENSG00000143379	SETDB1	100	92.266	ENSCGRG00001010822	Setdb1	100	91.802	Cricetulus_griseus_chok1gshd
ENSG00000143379	SETDB1	100	91.957	ENSCGRG00000005953	Setdb1	100	91.493	Cricetulus_griseus_crigri
ENSG00000143379	SETDB1	89	63.415	ENSCSEG00000002988	setdb1b	98	69.189	Cynoglossus_semilaevis
ENSG00000143379	SETDB1	90	68.586	ENSCVAG00000008877	setdb1b	99	68.586	Cyprinodon_variegatus
ENSG00000143379	SETDB1	97	55.556	ENSDARG00000099021	setdb1b	99	56.978	Danio_rerio
ENSG00000143379	SETDB1	100	96.077	ENSDNOG00000007754	SETDB1	100	96.077	Dasypus_novemcinctus
ENSG00000143379	SETDB1	100	92.819	ENSDORG00000006830	Setdb1	100	92.896	Dipodomys_ordii
ENSG00000143379	SETDB1	70	47.697	ENSEBUG00000005735	setdb1b	95	46.755	Eptatretus_burgeri
ENSG00000143379	SETDB1	100	96.613	ENSEASG00005002061	SETDB1	100	96.613	Equus_asinus_asinus
ENSG00000143379	SETDB1	100	96.933	ENSECAG00000023954	SETDB1	100	96.690	Equus_caballus
ENSG00000143379	SETDB1	100	87.127	ENSEEUG00000015825	SETDB1	83	95.798	Erinaceus_europaeus
ENSG00000143379	SETDB1	88	76.331	ENSELUG00000013948	setdb1b	98	76.331	Esox_lucius
ENSG00000143379	SETDB1	83	51.124	ENSELUG00000006204	-	78	53.134	Esox_lucius
ENSG00000143379	SETDB1	100	95.706	ENSFCAG00000009655	SETDB1	100	93.963	Felis_catus
ENSG00000143379	SETDB1	100	96.319	ENSFDAG00000021515	SETDB1	100	95.286	Fukomys_damarensis
ENSG00000143379	SETDB1	90	66.842	ENSFHEG00000022195	setdb1b	99	67.895	Fundulus_heteroclitus
ENSG00000143379	SETDB1	87	76.471	ENSGMOG00000005993	setdb1b	93	76.471	Gadus_morhua
ENSG00000143379	SETDB1	99	73.485	ENSGALG00000024051	SETDB1	92	73.349	Gallus_gallus
ENSG00000143379	SETDB1	91	59.732	ENSGAFG00000012805	setdb1b	99	60.667	Gambusia_affinis
ENSG00000143379	SETDB1	87	72.674	ENSGACG00000011675	setdb1b	93	73.837	Gasterosteus_aculeatus
ENSG00000143379	SETDB1	99	78.915	ENSGAGG00000005348	SETDB1	100	78.533	Gopherus_agassizii
ENSG00000143379	SETDB1	100	100.000	ENSGGOG00000016308	SETDB1	100	99.768	Gorilla_gorilla
ENSG00000143379	SETDB1	99	57.659	ENSHBUG00000004618	setdb1b	99	53.457	Haplochromis_burtoni
ENSG00000143379	SETDB1	100	96.319	ENSHGLG00000011098	SETDB1	100	95.128	Heterocephalus_glaber_female
ENSG00000143379	SETDB1	100	96.319	ENSHGLG00100009789	SETDB1	100	94.582	Heterocephalus_glaber_male
ENSG00000143379	SETDB1	88	68.108	ENSHCOG00000014567	setdb1b	98	68.649	Hippocampus_comes
ENSG00000143379	SETDB1	89	65.842	ENSIPUG00000004536	setdb1	98	72.067	Ictalurus_punctatus
ENSG00000143379	SETDB1	100	96.933	ENSSTOG00000006770	SETDB1	100	94.153	Ictidomys_tridecemlineatus
ENSG00000143379	SETDB1	87	66.842	ENSKMAG00000001197	setdb1b	91	67.368	Kryptolebias_marmoratus
ENSG00000143379	SETDB1	88	67.027	ENSLBEG00000025862	setdb1b	96	67.568	Labrus_bergylta
ENSG00000143379	SETDB1	99	69.306	ENSLACG00000011159	SETDB1	100	68.830	Latimeria_chalumnae
ENSG00000143379	SETDB1	100	95.092	ENSLAFG00000004006	SETDB1	100	94.266	Loxodonta_africana
ENSG00000143379	SETDB1	100	100.000	ENSMFAG00000042328	SETDB1	100	99.535	Macaca_fascicularis
ENSG00000143379	SETDB1	100	100.000	ENSMMUG00000023235	SETDB1	100	99.303	Macaca_mulatta
ENSG00000143379	SETDB1	100	100.000	ENSMNEG00000017223	SETDB1	100	99.458	Macaca_nemestrina
ENSG00000143379	SETDB1	100	100.000	ENSMLEG00000033050	SETDB1	100	99.535	Mandrillus_leucophaeus
ENSG00000143379	SETDB1	94	68.889	ENSMAMG00000015176	setdb1b	85	69.444	Mastacembelus_armatus
ENSG00000143379	SETDB1	99	57.755	ENSMZEG00005016099	setdb1b	98	70.270	Maylandia_zebra
ENSG00000143379	SETDB1	99	70.076	ENSMGAG00000001018	SETDB1	97	70.328	Meleagris_gallopavo
ENSG00000143379	SETDB1	88	92.391	ENSMAUG00000021391	Setdb1	100	92.391	Mesocricetus_auratus
ENSG00000143379	SETDB1	100	98.160	ENSMICG00000000425	SETDB1	100	96.530	Microcebus_murinus
ENSG00000143379	SETDB1	100	91.782	ENSMOCG00000017407	Setdb1	100	91.859	Microtus_ochrogaster
ENSG00000143379	SETDB1	89	64.706	ENSMMOG00000016162	setdb1b	99	68.984	Mola_mola
ENSG00000143379	SETDB1	100	88.415	ENSMODG00000018821	SETDB1	90	87.539	Monodelphis_domestica
ENSG00000143379	SETDB1	87	75.460	ENSMALG00000007801	setdb1b	97	61.841	Monopterus_albus
ENSG00000143379	SETDB1	100	91.201	MGP_CAROLIEiJ_G0025342	Setdb1	100	90.666	Mus_caroli
ENSG00000143379	SETDB1	100	90.840	ENSMUSG00000015697	Setdb1	100	90.458	Mus_musculus
ENSG00000143379	SETDB1	100	95.238	ENSMPUG00000004298	SETDB1	100	90.992	Mustela_putorius_furo
ENSG00000143379	SETDB1	100	92.711	ENSMLUG00000010486	SETDB1	100	92.407	Myotis_lucifugus
ENSG00000143379	SETDB1	100	92.638	ENSNGAG00000020151	Setdb1	100	91.409	Nannospalax_galili
ENSG00000143379	SETDB1	98	55.962	ENSNBRG00000003147	setdb1b	99	70.811	Neolamprologus_brichardi
ENSG00000143379	SETDB1	100	99.387	ENSNLEG00000009996	SETDB1	100	95.951	Nomascus_leucogenys
ENSG00000143379	SETDB1	100	80.185	ENSMEUG00000000555	-	100	79.954	Notamacropus_eugenii
ENSG00000143379	SETDB1	100	85.276	ENSMEUG00000006544	-	88	89.084	Notamacropus_eugenii
ENSG00000143379	SETDB1	100	93.865	ENSOPRG00000015349	SETDB1	100	92.344	Ochotona_princeps
ENSG00000143379	SETDB1	100	95.743	ENSODEG00000012471	SETDB1	100	95.588	Octodon_degus
ENSG00000143379	SETDB1	88	69.730	ENSONIG00000006454	setdb1b	99	58.650	Oreochromis_niloticus
ENSG00000143379	SETDB1	100	96.319	ENSOCUG00000003642	SETDB1	100	94.367	Oryctolagus_cuniculus
ENSG00000143379	SETDB1	94	66.337	ENSORLG00000010602	setdb1b	98	68.557	Oryzias_latipes
ENSG00000143379	SETDB1	80	70.130	ENSORLG00020008638	setdb1b	97	60.797	Oryzias_latipes_hni
ENSG00000143379	SETDB1	94	64.251	ENSORLG00015014543	setdb1b	98	66.834	Oryzias_latipes_hsok
ENSG00000143379	SETDB1	91	66.667	ENSOMEG00000009457	setdb1b	99	69.792	Oryzias_melastigma
ENSG00000143379	SETDB1	100	90.178	ENSOGAG00000010320	SETDB1	100	90.023	Otolemur_garnettii
ENSG00000143379	SETDB1	100	95.917	ENSOARG00000020880	SETDB1	100	95.917	Ovis_aries
ENSG00000143379	SETDB1	100	99.768	ENSPPAG00000041015	SETDB1	100	99.768	Pan_paniscus
ENSG00000143379	SETDB1	100	96.285	ENSPPRG00000005462	SETDB1	100	96.285	Panthera_pardus
ENSG00000143379	SETDB1	100	95.706	ENSPTIG00000014233	SETDB1	100	95.201	Panthera_tigris_altaica
ENSG00000143379	SETDB1	100	100.000	ENSPTRG00000001267	SETDB1	100	99.768	Pan_troglodytes
ENSG00000143379	SETDB1	100	100.000	ENSPANG00000020214	SETDB1	100	96.827	Papio_anubis
ENSG00000143379	SETDB1	98	56.936	ENSPKIG00000010963	setdb1b	100	56.780	Paramormyrops_kingsleyae
ENSG00000143379	SETDB1	63	73.723	ENSPSIG00000008407	SETDB1	85	79.567	Pelodiscus_sinensis
ENSG00000143379	SETDB1	93	92.703	ENSPEMG00000010553	Setdb1	100	92.046	Peromyscus_maniculatus_bairdii
ENSG00000143379	SETDB1	98	52.022	ENSPMAG00000001573	setdb1b	100	51.558	Petromyzon_marinus
ENSG00000143379	SETDB1	99	56.875	ENSPFOG00000004623	-	99	56.217	Poecilia_formosa
ENSG00000143379	SETDB1	99	54.808	ENSPFOG00000004429	setdb1b	97	70.270	Poecilia_formosa
ENSG00000143379	SETDB1	91	60.667	ENSPLAG00000017117	setdb1b	99	62.000	Poecilia_latipinna
ENSG00000143379	SETDB1	94	67.553	ENSPLAG00000019076	-	99	68.617	Poecilia_latipinna
ENSG00000143379	SETDB1	94	67.553	ENSPMEG00000006468	setdb1b	99	68.617	Poecilia_mexicana
ENSG00000143379	SETDB1	94	67.553	ENSPREG00000017459	setdb1b	99	68.617	Poecilia_reticulata
ENSG00000143379	SETDB1	100	99.613	ENSPPYG00000000887	SETDB1	100	99.613	Pongo_abelii
ENSG00000143379	SETDB1	100	93.281	ENSPCAG00000002527	SETDB1	100	93.824	Procavia_capensis
ENSG00000143379	SETDB1	100	98.160	ENSPCOG00000027869	SETDB1	100	96.981	Propithecus_coquereli
ENSG00000143379	SETDB1	100	97.546	ENSPVAG00000004355	SETDB1	93	94.191	Pteropus_vampyrus
ENSG00000143379	SETDB1	89	69.730	ENSPNYG00000003997	setdb1b	90	70.270	Pundamilia_nyererei
ENSG00000143379	SETDB1	89	63.850	ENSPNAG00000021617	setdb1b	52	70.652	Pygocentrus_nattereri
ENSG00000143379	SETDB1	100	90.728	ENSRNOG00000021143	Setdb1	100	90.345	Rattus_norvegicus
ENSG00000143379	SETDB1	100	100.000	ENSRBIG00000042359	SETDB1	100	99.458	Rhinopithecus_bieti
ENSG00000143379	SETDB1	100	100.000	ENSRROG00000032628	SETDB1	100	99.303	Rhinopithecus_roxellana
ENSG00000143379	SETDB1	100	98.773	ENSSBOG00000028608	SETDB1	100	98.537	Saimiri_boliviensis_boliviensis
ENSG00000143379	SETDB1	100	86.718	ENSSHAG00000012701	SETDB1	100	86.244	Sarcophilus_harrisii
ENSG00000143379	SETDB1	89	69.849	ENSSFOG00015022183	setdb1	99	57.734	Scleropages_formosus
ENSG00000143379	SETDB1	91	54.660	ENSSMAG00000015398	setdb1b	99	65.672	Scophthalmus_maximus
ENSG00000143379	SETDB1	92	64.929	ENSSDUG00000007513	setdb1b	99	68.750	Seriola_dumerili
ENSG00000143379	SETDB1	91	56.423	ENSSLDG00000015209	setdb1b	99	69.072	Seriola_lalandi_dorsalis
ENSG00000143379	SETDB1	99	76.923	ENSSPUG00000002969	SETDB1	100	75.969	Sphenodon_punctatus
ENSG00000143379	SETDB1	100	96.319	ENSSSCG00000006645	SETDB1	100	95.212	Sus_scrofa
ENSG00000143379	SETDB1	94	73.740	ENSTGUG00000004684	SETDB1	100	73.021	Taeniopygia_guttata
ENSG00000143379	SETDB1	91	66.845	ENSTRUG00000014641	setdb1b	98	66.845	Takifugu_rubripes
ENSG00000143379	SETDB1	99	53.483	ENSTNIG00000008065	setdb1b	99	55.046	Tetraodon_nigroviridis
ENSG00000143379	SETDB1	93	96.336	ENSTBEG00000009306	SETDB1	100	96.336	Tupaia_belangeri
ENSG00000143379	SETDB1	89	94.800	ENSTTRG00000006966	SETDB1	89	94.800	Tursiops_truncatus
ENSG00000143379	SETDB1	100	98.160	ENSUAMG00000026724	SETDB1	100	95.458	Ursus_americanus
ENSG00000143379	SETDB1	100	98.160	ENSUMAG00000003141	SETDB1	100	91.448	Ursus_maritimus
ENSG00000143379	SETDB1	100	98.160	ENSVPAG00000005440	SETDB1	78	97.842	Vicugna_pacos
ENSG00000143379	SETDB1	100	98.160	ENSVVUG00000011637	SETDB1	100	96.142	Vulpes_vulpes
ENSG00000143379	SETDB1	99	69.977	ENSXETG00000008936	setdb1	99	69.748	Xenopus_tropicalis
ENSG00000143379	SETDB1	98	56.933	ENSXCOG00000019497	setdb1b	90	72.316	Xiphophorus_couchianus
ENSG00000143379	SETDB1	95	67.553	ENSXMAG00000016600	setdb1b	99	68.085	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	27029610.	IDA	Function
GO:0005515	protein binding	16682412.17066076.17577629.20871592.21170338.26022416.27029610.27732843.29774127.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	27732843.	IMP	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005737	cytoplasm	27732843.	IMP	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0007265	Ras protein signal transduction	24623306.	IMP	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0018024	histone-lysine N-methyltransferase activity	14536086.	IDA	Function
GO:0033273	response to vitamin	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045471	response to ethanol	-	IEA	Process
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	-	ISS	Process
GO:0046974	histone methyltransferase activity (H3-K9 specific)	14536086.	IDA	Function
GO:0051567	histone H3-K9 methylation	-	IEA	Process
GO:0090309	positive regulation of methylation-dependent chromatin silencing	24623306.27732843.	IMP	Process
GO:0090309	positive regulation of methylation-dependent chromatin silencing	-	ISS	Process
GO:1990841	promoter-specific chromatin binding	24623306.	IDA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.