EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15351706	Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor.	Biochem Biophys Res Commun	2004 Oct 8	Nishanian TG	-
29397868	SF3B4 as an early-stage diagnostic marker and driver of hepatocellular carcinoma.	BMB Rep	2018 Feb	Shen Q	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	149927876	5'UTR	novel		0.36
BLCA	chr1	149923625	Missense_Mutation	novel	R398W	0.8
BLCA	chr1	149926024	Missense_Mutation	NA	S242F	0.4
BLCA	chr1	149923709	Missense_Mutation	novel	P370S	0.76
BRCA	chr1	149926722	Missense_Mutation	NA	F120L	0.46	RRM_1
BRCA	chr1	149927847	5'UTR	novel		0.09
BRCA	chr1	149923867	Frame_Shift_Ins	rs782357237	*R354Pfs132**	0.36
BRCA	chr1	149923867	Missense_Mutation	NA	R354L	0.35
BRCA	chr1	149927840	5'UTR	novel		0.23
BRCA	chr1	149926722	Silent	NA	F120F	0.25
BRCA	chr1	149926755	Frame_Shift_Del	NA	*P109Rfs3**	0.14	RRM_1
COAD	chr1	149923662	Silent	NA	Y385Y	0.15
COAD	chr1	149925880	Missense_Mutation	novel	H290R	0.2
COAD	chr1	149923697	Missense_Mutation	NA	R374C	0.33
COAD	chr1	149923670	Frame_Shift_Del	rs387907187	*H383Mfs75**	0.28
COAD	chr1	149927833	5'UTR	novel		0.22
COAD	chr1	149923558	Missense_Mutation	novel	G420D	0.14
COAD	chr1	149927814	5'UTR	novel		0.32
COAD	chr1	149923868	Frame_Shift_Del	novel	*R354Efs26**	0.11
COAD	chr1	149923670	Frame_Shift_Del	rs387907187	*H383Mfs75**	0.44
COAD	chr1	149923867	Frame_Shift_Ins	NA	*R354Pfs27**	0.49
COAD	chr1	149923568	Missense_Mutation	novel	P417T	0.05
COAD	chr1	149927846	5'UTR	novel		0.37
COAD	chr1	149923988	Missense_Mutation	NA	H314Y	0.27
COAD	chr1	149926504	Missense_Mutation	NA	R193Q	0.22
COAD	chr1	149923845	Silent	novel	P361P	0.3
COAD	chr1	149923670	Frame_Shift_Del	rs387907187	*H383Mfs75**	0.31
ESCA	chr1	149923867	Frame_Shift_Ins	rs782357237	*R354Pfs132**	0.26
ESCA	chr1	149926529	Missense_Mutation	novel	E185K	0.22
GBM	chr1	149926391	Missense_Mutation	novel	G231W	0.23
GBM	chr1	149927169	Nonsense_Mutation	novel	Q54*	0.04
GBM	chr1	149926647	Silent	novel	A145A	0.11
GBM	chr1	149926608	Silent	novel	A158A	0.09
GBM	chr1	149927181	Missense_Mutation	novel	T50S	0.27
GBM	chr1	149926465	Missense_Mutation	novel	R206H	0.24
LIHC	chr1	149926536	Silent	NA	S182S	0.19
LIHC	chr1	149927800	5'UTR	novel		0.11
LIHC	chr1	149923927	Missense_Mutation	novel	P334R	0.28
LUAD	chr1	149923889	Missense_Mutation	novel	P347T	0.21
LUAD	chr1	149926475	Nonsense_Mutation	novel	Q203*	0.43
LUAD	chr1	149923958	Missense_Mutation	NA	A324S	0.21
LUAD	chr1	149926390	Missense_Mutation	NA	G231V	0.65
LUAD	chr1	149926504	Missense_Mutation	NA	R193P	0.17
LUAD	chr1	149923897	Missense_Mutation	NA	P344R	0.15
LUAD	chr1	149925853	Missense_Mutation	novel	G299D	0.28
LUAD	chr1	149923707	Silent	rs782435530	P370P	0.39
LUAD	chr1	149926541	Missense_Mutation	NA	D181H	0.44
LUSC	chr1	149923573	Missense_Mutation	novel	R415Q	0.13
LUSC	chr1	149926730	Missense_Mutation	novel	D118Y	0.32	RRM_1
LUSC	chr1	149926848	Silent	NA	K78K	0.24
LUSC	chr1	149926622	Missense_Mutation	novel	A154P	0.15
LUSC	chr1	149926741	Missense_Mutation	novel	K114R	0.28	RRM_1
LUSC	chr1	149926692	Silent	novel	P130P	0.15
LUSC	chr1	149923648	Missense_Mutation	NA	R390L	0.68
OV	chr1	149927196	Missense_Mutation	novel	P45S	0.03
OV	chr1	149923667	Missense_Mutation	NA	G384R	0.52
OV	chr1	149927203	Frame_Shift_Ins	NA	*H43Pfs21**	0.39
OV	chr1	149925839	Missense_Mutation	NA	P304S	0.21
PRAD	chr1	149926375	Splice_Site	novel	X236_splice	0.57
SKCM	chr1	149924013	Splice_Region	NA	G305G	0.42
SKCM	chr1	149926479	Silent	novel	L201L	0.25
SKCM	chr1	149926384	Missense_Mutation	novel	P233L	0.41
SKCM	chr1	149926385	Missense_Mutation	novel	P233S	0.41
SKCM	chr1	149923562	Nonsense_Mutation	NA	R419*	0.29
SKCM	chr1	149927226	Nonsense_Mutation	NA	Q35*	0.16
SKCM	chr1	149926692	Silent	novel	P130P	0.53
SKCM	chr1	149923522	3'UTR	novel		0.55
SKCM	chr1	149923609	Missense_Mutation	NA	P403L	0.48
SKCM	chr1	149923580	Missense_Mutation	rs781816117	P413S	0.26
SKCM	chr1	149923578	Silent	novel	P413P	0.38
SKCM	chr1	149923688	Missense_Mutation	NA	P377S	0.21
STAD	chr1	149926446	Silent	NA	A212A	0.25
STAD	chr1	149926541	Missense_Mutation	NA	D181N	0.65
STAD	chr1	149923598	Missense_Mutation	NA	T407S	0.46
STAD	chr1	149926824	Silent	NA	V86V	0.29
STAD	chr1	149925847	Missense_Mutation	novel	M301T	0.32
STAD	chr1	149926885	Missense_Mutation	NA	D66G	0.16	RRM_1
STAD	chr1	149927236	Missense_Mutation	NA	E31D	0.08
STAD	chr1	149926377	Splice_Region	NA	P235P	0.22
STAD	chr1	149926526	Missense_Mutation	NA	R186C	0.38
UCEC	chr1	149925918	Silent	rs781792461	S277S	0.48
UCEC	chr1	149926508	Missense_Mutation	novel	E192K	0.5
UCEC	chr1	149923648	Missense_Mutation	novel	R390Q	0.28
UCEC	chr1	149926465	Missense_Mutation	novel	R206H	0.44
UCEC	chr1	149923620	Silent	rs782240590	G399G	0.43
UCEC	chr1	149925971	Missense_Mutation	novel	A260T	0.19
UCEC	chr1	149926562	Missense_Mutation	novel	V174I	0.25
UCEC	chr1	149923867	Frame_Shift_Ins	rs782357237	*R354Pfs132**	0.41
UCEC	chr1	149927238	Missense_Mutation	novel	E31K	0.26
UCEC	chr1	149923446	3'UTR	novel		0.09
UCEC	chr1	149923525	3'UTR	novel		0.17
UCEC	chr1	149923513	3'UTR	novel		0.42
UCEC	chr1	149923557	Silent	novel	G420G	0.15
UCEC	chr1	149926562	Missense_Mutation	novel	V174I	0.13
UCEC	chr1	149923867	Missense_Mutation	novel	R354Q	0.22
UCEC	chr1	149924015	Splice_Site	novel	X305_splice	0.34
UCEC	chr1	149925928	Missense_Mutation	novel	G274A	0.14
UCEC	chr1	149923696	Missense_Mutation	novel	R374H	0.38
UCEC	chr1	149923868	Frame_Shift_Del	novel	*R354Efs26**	0.28
UCEC	chr1	149926583	Missense_Mutation	NA	L167I	0.19
UCEC	chr1	149926408	Missense_Mutation	NA	V225A	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1444	0.11282
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3804	0.0022446
KIRC	AMP	0.0928	0.059566
LUSC	AMP	0.4032	1.6618e-06
PAAD	AMP	0.2174	0.085665
PCPG	AMP	0.1481	0.00029562
READ	AMP	0.2545	0.025154
SARC	AMP	0.3346	4.3422e-08
SKCM	AMP	0.4632	9.6912e-06
TGCT	AMP	0.3467	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.00085	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
SKCM	0.0061	Kaplan-Meier Survival Analysis
KIRP	0.00035	Kaplan-Meier Survival Analysis
COAD	0.037	Kaplan-Meier Survival Analysis
LAML	0.003	Kaplan-Meier Survival Analysis
UCEC	0.0097	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Paralog

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000143368 (Gene tree)
Gene ID: 10262
Gene Symbol: SF3B4
Alias: SAP49|SF3b49|Hsh49
Full Name: splicing factor 3b subunit 4
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 5,028 bases
Position: chr1:149,923,317-149,928,344
Accession: 10771
Summary: This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000271628	RRM_1	PF00076.22	1.1e-38	1	2
ENSP00000271628	RRM_1	PF00076.22	1.1e-38	2	2
ENSP00000391114	RRM_1	PF00076.22	6.3e-31	1	2
ENSP00000391114	RRM_1	PF00076.22	6.3e-31	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

RNA-binding sites

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9436903	Conservation of structure and subunit interactions in yeast homologues of splicing factor 3b (SF3b) subunits.	RNA	1998 Jan	Igel H	-
7664121	Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus.	Nat Struct Biol	1995 Jul	Mosyak L	-
20554048	Use of the spliceosomal protein U1A to facilitate crystallization and structure determination of complex RNAs.	Methods	2010 Oct	Ferre-D'Amare AR	doi: 10.1016/j.ymeth.2010.06.008
9163526	Polycistronic expression and RNA-binding specificity of the C. elegans homologue of the spliceosome-associated protein SAP49.	J Biochem	1997 Apr	Tanaka Y	-
8841523	Crystal structure of the U1A spliceosomal protein complexed with its cognate RNA hairpin.	Nucleic Acids Symp Ser	1995	Nagai K	-
10360356	Simulations of the dynamics at an RNA-protein interface.	Nat Struct Biol	1999 Jun	Hermann T	-
7984237	Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.	Nature	1994 Dec 1	Oubridge C	-
1454520	Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro.	Nucleic Acids Res	1992 Nov 11	Stripecke R	-
7958871	The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site.	Genes Dev	1994 Aug 15	Champion-Arnaud P	-
18076038	Complex assembly mechanism and an RNA-binding mode of the human p14-SF3b155 spliceosomal protein complex identified by NMR solution structure and functional analyses.	Proteins	2008 Jun	Kuwasako K	-
31004060	Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum.	Proc Natl Acad Sci U S A	2019 May 7	Ueno T	doi: 10.1073/pnas.1901742116
8696973	RNA-protein complexes.	Curr Opin Struct Biol	1996 Feb	Nagai K	-
7783201	Crystallisation of RNA-protein complexes. II. The application of protein engineering for crystallisation of the U1A protein-RNA complex.	J Mol Biol	1995 Jun 2	Oubridge C	-
11566759	Calculations of free-energy contributions to protein-RNA complex stabilization.	Biophys J	2001 Oct	Olson MA	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000271628	SF3B4-201	2085	-	ENSP00000271628	424 (aa)	-	Q15427
ENST00000457312	SF3B4-202	826	-	ENSP00000391114	190 (aa)	-	Q5SZ64

Gene Model

Click here to download ENSG00000143368's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143368's network

Paralog

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000143368	SF3B4	73	30.667	ENSG00000180098	TRNAU1AP	62	30.667
ENSG00000143368	SF3B4	77	36.000	ENSG00000151846	PABPC3	58	36.612
ENSG00000143368	SF3B4	75	46.237	ENSG00000090621	PABPC4	98	44.737
ENSG00000143368	SF3B4	78	34.615	ENSG00000186288	PABPC1L2A	90	34.615
ENSG00000143368	SF3B4	63	35.246	ENSG00000101489	CELF4	51	36.145
ENSG00000143368	SF3B4	81	37.821	ENSG00000101104	PABPC1L	97	38.095
ENSG00000143368	SF3B4	74	36.232	ENSG00000100461	RBM23	66	34.694
ENSG00000143368	SF3B4	65	32.374	ENSG00000179950	PUF60	62	31.429
ENSG00000143368	SF3B4	74	34.559	ENSG00000066044	ELAVL1	94	32.335
ENSG00000143368	SF3B4	74	35.294	ENSG00000162374	ELAVL4	90	30.726
ENSG00000143368	SF3B4	54	33.333	ENSG00000138668	HNRNPD	99	32.456
ENSG00000143368	SF3B4	93	33.333	ENSG00000070756	PABPC1	98	40.909
ENSG00000143368	SF3B4	72	31.757	ENSG00000131051	RBM39	72	30.899
ENSG00000143368	SF3B4	72	32.143	ENSG00000140488	CELF6	56	30.000
ENSG00000143368	SF3B4	71	35.938	ENSG00000116001	TIA1	88	37.956
ENSG00000143368	SF3B4	78	42.105	ENSG00000254535	PABPC4L	97	42.105
ENSG00000143368	SF3B4	72	40.152	ENSG00000174740	PABPC5	93	40.769
ENSG00000143368	SF3B4	74	35.294	ENSG00000107105	ELAVL2	93	30.939
ENSG00000143368	SF3B4	78	34.615	ENSG00000184388	PABPC1L2B	90	34.615
ENSG00000143368	SF3B4	74	39.706	ENSG00000196361	ELAVL3	67	38.571
ENSG00000143368	SF3B4	71	36.719	ENSG00000151923	TIAL1	92	37.500
ENSG00000143368	SF3B4	71	30.986	ENSG00000099783	HNRNPM	56	32.258

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143368	SF3B4	98	96.791	ENSAPOG00000017647	sf3b4	77	82.445	Acanthochromis_polyacanthus
ENSG00000143368	SF3B4	100	100.000	ENSAMEG00000010073	SF3B4	100	99.764	Ailuropoda_melanoleuca
ENSG00000143368	SF3B4	99	95.745	ENSACIG00000018455	sf3b4	67	96.930	Amphilophus_citrinellus
ENSG00000143368	SF3B4	89	100.000	ENSAOCG00000019801	sf3b4	77	82.445	Amphiprion_ocellaris
ENSG00000143368	SF3B4	89	100.000	ENSAPEG00000010365	sf3b4	77	82.445	Amphiprion_percula
ENSG00000143368	SF3B4	98	96.791	ENSATEG00000012844	sf3b4	76	81.562	Anabas_testudineus
ENSG00000143368	SF3B4	90	100.000	ENSACAG00000010019	SF3B4	90	89.817	Anolis_carolinensis
ENSG00000143368	SF3B4	100	100.000	ENSANAG00000031025	SF3B4	100	100.000	Aotus_nancymaae
ENSG00000143368	SF3B4	99	95.767	ENSACLG00000014260	sf3b4	76	81.505	Astatotilapia_calliptera
ENSG00000143368	SF3B4	98	96.791	ENSAMXG00000008282	sf3b4	60	96.250	Astyanax_mexicanus
ENSG00000143368	SF3B4	100	100.000	ENSBTAG00000012495	SF3B4	100	99.764	Bos_taurus
ENSG00000143368	SF3B4	100	98.421	ENSBTAG00000012793	-	93	96.354	Bos_taurus
ENSG00000143368	SF3B4	90	82.474	ENSCJAG00000042351	SF3B4	87	82.474	Callithrix_jacchus
ENSG00000143368	SF3B4	100	100.000	ENSCAFG00000011617	SF3B4	100	99.292	Canis_familiaris
ENSG00000143368	SF3B4	100	100.000	ENSCAFG00020019775	SF3B4	100	99.292	Canis_lupus_dingo
ENSG00000143368	SF3B4	100	100.000	ENSCHIG00000025663	-	100	99.764	Capra_hircus
ENSG00000143368	SF3B4	100	100.000	ENSTSYG00000009295	SF3B4	100	100.000	Carlito_syrichta
ENSG00000143368	SF3B4	94	100.000	ENSCAPG00000006451	SF3B4	50	100.000	Cavia_aperea
ENSG00000143368	SF3B4	100	100.000	ENSCPOG00000008267	SF3B4	100	99.528	Cavia_porcellus
ENSG00000143368	SF3B4	100	99.474	ENSCCAG00000021751	-	69	93.210	Cebus_capucinus
ENSG00000143368	SF3B4	100	92.105	ENSCCAG00000019823	-	77	86.810	Cebus_capucinus
ENSG00000143368	SF3B4	100	100.000	ENSCATG00000033114	SF3B4	100	100.000	Cercocebus_atys
ENSG00000143368	SF3B4	100	100.000	ENSCLAG00000015851	SF3B4	100	99.528	Chinchilla_lanigera
ENSG00000143368	SF3B4	100	100.000	ENSCSAG00000018129	SF3B4	100	100.000	Chlorocebus_sabaeus
ENSG00000143368	SF3B4	99	97.354	ENSCPBG00000008041	SF3B4	91	90.625	Chrysemys_picta_bellii
ENSG00000143368	SF3B4	91	90.116	ENSCING00000002337	-	57	90.521	Ciona_intestinalis
ENSG00000143368	SF3B4	88	89.881	ENSCSAVG00000007809	-	88	89.697	Ciona_savignyi
ENSG00000143368	SF3B4	100	100.000	ENSCANG00000035579	SF3B4	100	100.000	Colobus_angolensis_palliatus
ENSG00000143368	SF3B4	100	100.000	ENSCGRG00001003590	Sf3b4	100	99.528	Cricetulus_griseus_chok1gshd
ENSG00000143368	SF3B4	100	100.000	ENSCGRG00000016914	Sf3b4	100	99.528	Cricetulus_griseus_crigri
ENSG00000143368	SF3B4	99	94.180	ENSCVAG00000005536	sf3b4	54	100.000	Cyprinodon_variegatus
ENSG00000143368	SF3B4	98	96.791	ENSDARG00000018574	sf3b4	77	80.878	Danio_rerio
ENSG00000143368	SF3B4	100	100.000	ENSDNOG00000048908	-	99	96.875	Dasypus_novemcinctus
ENSG00000143368	SF3B4	100	81.675	ENSDNOG00000037231	-	76	81.789	Dasypus_novemcinctus
ENSG00000143368	SF3B4	100	100.000	ENSDORG00000016366	Sf3b4	100	99.764	Dipodomys_ordii
ENSG00000143368	SF3B4	97	87.568	ENSETEG00000008963	SF3B4	76	92.593	Echinops_telfairi
ENSG00000143368	SF3B4	100	100.000	ENSEASG00005001477	SF3B4	100	99.764	Equus_asinus_asinus
ENSG00000143368	SF3B4	100	100.000	ENSECAG00000024737	SF3B4	100	99.764	Equus_caballus
ENSG00000143368	SF3B4	100	96.842	ENSELUG00000012876	sf3b4	60	97.083	Esox_lucius
ENSG00000143368	SF3B4	100	100.000	ENSFCAG00000010106	SF3B4	100	99.764	Felis_catus
ENSG00000143368	SF3B4	100	100.000	ENSFDAG00000009286	SF3B4	100	99.528	Fukomys_damarensis
ENSG00000143368	SF3B4	98	96.257	ENSGMOG00000002519	sf3b4	67	97.368	Gadus_morhua
ENSG00000143368	SF3B4	90	100.000	ENSGALG00000013352	SF3B4	90	89.556	Gallus_gallus
ENSG00000143368	SF3B4	98	96.791	ENSGAFG00000010181	sf3b4	58	97.807	Gambusia_affinis
ENSG00000143368	SF3B4	100	96.842	ENSGACG00000003819	sf3b4	58	97.807	Gasterosteus_aculeatus
ENSG00000143368	SF3B4	99	97.354	ENSGAGG00000025055	SF3B4	79	90.365	Gopherus_agassizii
ENSG00000143368	SF3B4	100	100.000	ENSGGOG00000004761	SF3B4	100	100.000	Gorilla_gorilla
ENSG00000143368	SF3B4	93	86.034	ENSGGOG00000038845	-	54	89.524	Gorilla_gorilla
ENSG00000143368	SF3B4	99	95.767	ENSHBUG00000002028	sf3b4	76	81.505	Haplochromis_burtoni
ENSG00000143368	SF3B4	100	100.000	ENSHGLG00000012360	SF3B4	100	99.528	Heterocephalus_glaber_female
ENSG00000143368	SF3B4	100	100.000	ENSHGLG00100008533	SF3B4	100	98.349	Heterocephalus_glaber_male
ENSG00000143368	SF3B4	89	99.412	ENSHCOG00000003014	sf3b4	57	96.491	Hippocampus_comes
ENSG00000143368	SF3B4	100	96.316	ENSIPUG00000012242	Sf3b4	77	81.250	Ictalurus_punctatus
ENSG00000143368	SF3B4	100	100.000	ENSSTOG00000000684	-	100	99.764	Ictidomys_tridecemlineatus
ENSG00000143368	SF3B4	99	73.545	ENSSTOG00000029627	-	74	67.913	Ictidomys_tridecemlineatus
ENSG00000143368	SF3B4	76	84.052	ENSJJAG00000022500	Sf3b4	95	84.052	Jaculus_jaculus
ENSG00000143368	SF3B4	100	96.316	ENSKMAG00000008154	sf3b4	58	98.246	Kryptolebias_marmoratus
ENSG00000143368	SF3B4	99	97.354	ENSLBEG00000026818	sf3b4	57	98.246	Labrus_bergylta
ENSG00000143368	SF3B4	97	96.757	ENSLACG00000004436	SF3B4	87	85.312	Latimeria_chalumnae
ENSG00000143368	SF3B4	99	96.825	ENSLOCG00000009048	sf3b4	75	85.266	Lepisosteus_oculatus
ENSG00000143368	SF3B4	100	100.000	ENSLAFG00000008531	SF3B4	100	99.294	Loxodonta_africana
ENSG00000143368	SF3B4	100	100.000	ENSMFAG00000042395	SF3B4	100	100.000	Macaca_fascicularis
ENSG00000143368	SF3B4	95	81.215	ENSMFAG00000039067	-	57	80.841	Macaca_fascicularis
ENSG00000143368	SF3B4	100	100.000	ENSMMUG00000007256	SF3B4	100	100.000	Macaca_mulatta
ENSG00000143368	SF3B4	100	100.000	ENSMNEG00000031839	SF3B4	100	100.000	Macaca_nemestrina
ENSG00000143368	SF3B4	95	80.663	ENSMNEG00000031526	-	57	80.374	Macaca_nemestrina
ENSG00000143368	SF3B4	100	100.000	ENSMLEG00000038667	SF3B4	100	100.000	Mandrillus_leucophaeus
ENSG00000143368	SF3B4	100	96.842	ENSMAMG00000014692	sf3b4	60	97.083	Mastacembelus_armatus
ENSG00000143368	SF3B4	99	95.767	ENSMZEG00005026741	sf3b4	76	81.505	Maylandia_zebra
ENSG00000143368	SF3B4	90	100.000	ENSMGAG00000000653	SF3B4	91	88.083	Meleagris_gallopavo
ENSG00000143368	SF3B4	100	100.000	ENSMAUG00000015266	Sf3b4	100	99.528	Mesocricetus_auratus
ENSG00000143368	SF3B4	100	100.000	ENSMICG00000044961	SF3B4	100	99.764	Microcebus_murinus
ENSG00000143368	SF3B4	100	96.842	ENSMOCG00000014155	-	100	94.458	Microtus_ochrogaster
ENSG00000143368	SF3B4	100	100.000	ENSMOCG00000013658	-	100	99.528	Microtus_ochrogaster
ENSG00000143368	SF3B4	100	96.842	ENSMMOG00000018032	sf3b4	58	97.807	Mola_mola
ENSG00000143368	SF3B4	100	100.000	ENSMODG00000018767	SF3B4	100	99.057	Monodelphis_domestica
ENSG00000143368	SF3B4	89	100.000	ENSMALG00000006174	sf3b4	57	97.368	Monopterus_albus
ENSG00000143368	SF3B4	100	100.000	MGP_CAROLIEiJ_G0025365	Sf3b4	100	99.292	Mus_caroli
ENSG00000143368	SF3B4	100	100.000	ENSMUSG00000068856	Sf3b4	100	99.528	Mus_musculus
ENSG00000143368	SF3B4	100	100.000	MGP_PahariEiJ_G0026809	Sf3b4	100	99.528	Mus_pahari
ENSG00000143368	SF3B4	100	100.000	MGP_SPRETEiJ_G0026309	Sf3b4	100	99.528	Mus_spretus
ENSG00000143368	SF3B4	100	100.000	ENSMPUG00000005563	SF3B4	100	99.764	Mustela_putorius_furo
ENSG00000143368	SF3B4	100	99.528	ENSMLUG00000010789	SF3B4	100	99.528	Myotis_lucifugus
ENSG00000143368	SF3B4	100	100.000	ENSNGAG00000016337	Sf3b4	100	99.292	Nannospalax_galili
ENSG00000143368	SF3B4	99	96.296	ENSNBRG00000013865	sf3b4	76	81.818	Neolamprologus_brichardi
ENSG00000143368	SF3B4	97	89.730	ENSNLEG00000000537	-	82	85.185	Nomascus_leucogenys
ENSG00000143368	SF3B4	100	70.327	ENSNLEG00000009693	-	100	70.327	Nomascus_leucogenys
ENSG00000143368	SF3B4	81	100.000	ENSMEUG00000003272	SF3B4	82	100.000	Notamacropus_eugenii
ENSG00000143368	SF3B4	99	97.150	ENSOPRG00000010808	SF3B4	99	97.150	Ochotona_princeps
ENSG00000143368	SF3B4	99	76.190	ENSODEG00000008916	-	84	71.827	Octodon_degus
ENSG00000143368	SF3B4	97	81.720	ENSODEG00000003597	-	79	86.751	Octodon_degus
ENSG00000143368	SF3B4	99	95.767	ENSONIG00000002730	sf3b4	57	97.807	Oreochromis_niloticus
ENSG00000143368	SF3B4	84	100.000	ENSOANG00000004768	-	50	81.776	Ornithorhynchus_anatinus
ENSG00000143368	SF3B4	82	58.974	ENSOANG00000020581	-	99	58.974	Ornithorhynchus_anatinus
ENSG00000143368	SF3B4	100	100.000	ENSOCUG00000004614	SF3B4	100	99.764	Oryctolagus_cuniculus
ENSG00000143368	SF3B4	99	96.296	ENSORLG00000003062	sf3b4	59	97.807	Oryzias_latipes
ENSG00000143368	SF3B4	99	96.296	ENSORLG00020000687	sf3b4	57	97.807	Oryzias_latipes_hni
ENSG00000143368	SF3B4	99	96.296	ENSORLG00015010989	sf3b4	57	97.807	Oryzias_latipes_hsok
ENSG00000143368	SF3B4	99	96.296	ENSOMEG00000013694	sf3b4	57	97.807	Oryzias_melastigma
ENSG00000143368	SF3B4	100	100.000	ENSOGAG00000006265	SF3B4	100	99.764	Otolemur_garnettii
ENSG00000143368	SF3B4	99	81.383	ENSOARG00000007368	-	77	79.375	Ovis_aries
ENSG00000143368	SF3B4	100	100.000	ENSOARG00000020718	-	100	99.764	Ovis_aries
ENSG00000143368	SF3B4	97	89.189	ENSPPAG00000030024	-	78	82.716	Pan_paniscus
ENSG00000143368	SF3B4	100	100.000	ENSPPAG00000040904	SF3B4	100	100.000	Pan_paniscus
ENSG00000143368	SF3B4	100	100.000	ENSPPRG00000007384	SF3B4	100	99.764	Panthera_pardus
ENSG00000143368	SF3B4	100	100.000	ENSPTIG00000014530	SF3B4	100	99.292	Panthera_tigris_altaica
ENSG00000143368	SF3B4	100	100.000	ENSPTRG00000001243	SF3B4	100	100.000	Pan_troglodytes
ENSG00000143368	SF3B4	97	89.189	ENSPTRG00000049727	-	59	90.254	Pan_troglodytes
ENSG00000143368	SF3B4	100	100.000	ENSPANG00000005126	SF3B4	100	100.000	Papio_anubis
ENSG00000143368	SF3B4	100	96.842	ENSPKIG00000020669	sf3b4	60	98.246	Paramormyrops_kingsleyae
ENSG00000143368	SF3B4	99	97.354	ENSPSIG00000009565	SF3B4	69	97.354	Pelodiscus_sinensis
ENSG00000143368	SF3B4	63	65.455	ENSPMGG00000023148	-	74	95.588	Periophthalmus_magnuspinnatus
ENSG00000143368	SF3B4	100	100.000	ENSPEMG00000017568	Sf3b4	100	99.528	Peromyscus_maniculatus_bairdii
ENSG00000143368	SF3B4	89	95.294	ENSPMAG00000007842	-	50	95.283	Petromyzon_marinus
ENSG00000143368	SF3B4	100	100.000	ENSPCIG00000008765	SF3B4	100	99.057	Phascolarctos_cinereus
ENSG00000143368	SF3B4	100	95.263	ENSPFOG00000005754	sf3b4	58	97.368	Poecilia_formosa
ENSG00000143368	SF3B4	100	95.263	ENSPLAG00000001401	sf3b4	63	97.368	Poecilia_latipinna
ENSG00000143368	SF3B4	99	95.767	ENSPREG00000011076	sf3b4	57	97.807	Poecilia_reticulata
ENSG00000143368	SF3B4	87	98.788	ENSPCAG00000000392	SF3B4	63	96.635	Procavia_capensis
ENSG00000143368	SF3B4	100	100.000	ENSPCOG00000015399	SF3B4	100	99.764	Propithecus_coquereli
ENSG00000143368	SF3B4	100	100.000	ENSPVAG00000014171	SF3B4	100	99.764	Pteropus_vampyrus
ENSG00000143368	SF3B4	99	95.767	ENSPNYG00000012700	sf3b4	76	81.505	Pundamilia_nyererei
ENSG00000143368	SF3B4	98	96.791	ENSPNAG00000000686	sf3b4	79	80.938	Pygocentrus_nattereri
ENSG00000143368	SF3B4	100	100.000	ENSRNOG00000021181	Sf3b4	100	99.528	Rattus_norvegicus
ENSG00000143368	SF3B4	100	100.000	ENSRBIG00000043392	SF3B4	100	100.000	Rhinopithecus_bieti
ENSG00000143368	SF3B4	96	75.410	ENSRROG00000028213	-	91	67.914	Rhinopithecus_roxellana
ENSG00000143368	SF3B4	100	100.000	ENSRROG00000029366	SF3B4	100	100.000	Rhinopithecus_roxellana
ENSG00000143368	SF3B4	79	37.195	YOR319W	-	91	37.949	Saccharomyces_cerevisiae
ENSG00000143368	SF3B4	100	99.764	ENSSBOG00000012310	-	100	99.764	Saimiri_boliviensis_boliviensis
ENSG00000143368	SF3B4	100	83.158	ENSSBOG00000025174	-	73	79.567	Saimiri_boliviensis_boliviensis
ENSG00000143368	SF3B4	100	99.474	ENSSHAG00000004043	SF3B4	100	98.688	Sarcophilus_harrisii
ENSG00000143368	SF3B4	100	96.842	ENSSFOG00015008864	sf3b4	56	98.246	Scleropages_formosus
ENSG00000143368	SF3B4	89	100.000	ENSSMAG00000006837	sf3b4	77	82.132	Scophthalmus_maximus
ENSG00000143368	SF3B4	100	96.842	ENSSDUG00000012064	sf3b4	76	82.188	Seriola_dumerili
ENSG00000143368	SF3B4	100	96.842	ENSSLDG00000014226	sf3b4	60	97.083	Seriola_lalandi_dorsalis
ENSG00000143368	SF3B4	99	97.354	ENSSPUG00000001028	SF3B4	57	98.684	Sphenodon_punctatus
ENSG00000143368	SF3B4	100	97.368	ENSSPAG00000019219	sf3b4	76	82.500	Stegastes_partitus
ENSG00000143368	SF3B4	100	100.000	ENSSSCG00000006665	-	100	99.528	Sus_scrofa
ENSG00000143368	SF3B4	100	61.579	ENSSSCG00000039440	-	79	65.741	Sus_scrofa
ENSG00000143368	SF3B4	99	96.825	ENSTGUG00000004470	SF3B4	90	98.246	Taeniopygia_guttata
ENSG00000143368	SF3B4	97	96.196	ENSTRUG00000004516	sf3b4	57	96.491	Takifugu_rubripes
ENSG00000143368	SF3B4	98	96.257	ENSTNIG00000009156	sf3b4	58	97.368	Tetraodon_nigroviridis
ENSG00000143368	SF3B4	100	100.000	ENSTTRG00000005217	SF3B4	100	99.764	Tursiops_truncatus
ENSG00000143368	SF3B4	100	100.000	ENSUAMG00000022468	SF3B4	100	99.764	Ursus_americanus
ENSG00000143368	SF3B4	100	100.000	ENSUMAG00000003802	SF3B4	100	98.821	Ursus_maritimus
ENSG00000143368	SF3B4	100	100.000	ENSVPAG00000008152	SF3B4	100	99.757	Vicugna_pacos
ENSG00000143368	SF3B4	100	100.000	ENSVVUG00000007732	-	100	92.584	Vulpes_vulpes
ENSG00000143368	SF3B4	100	96.842	ENSVVUG00000022697	-	58	96.014	Vulpes_vulpes
ENSG00000143368	SF3B4	89	100.000	ENSXETG00000011038	sf3b4	53	100.000	Xenopus_tropicalis
ENSG00000143368	SF3B4	98	96.791	ENSXCOG00000019895	sf3b4	58	97.807	Xiphophorus_couchianus
ENSG00000143368	SF3B4	98	96.791	ENSXMAG00000003772	sf3b4	58	97.807	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000375	RNA splicing, via transesterification reactions	7958871.	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	9731529.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	29360106.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	16189514.17474147.21516116.21988832.22365833.25416956.26871637.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	29360106.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	21873635.	IBA	Component
GO:0005681	spliceosomal complex	9731529.	IDA	Component
GO:0005689	U12-type spliceosomal complex	21873635.	IBA	Component
GO:0005689	U12-type spliceosomal complex	15146077.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0006397	mRNA processing	7958871.	TAS	Process
GO:0008380	RNA splicing	7958871.	TAS	Process
GO:0048026	positive regulation of mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0071005	U2-type precatalytic spliceosome	29360106.	IDA	Component
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

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Expression

Transcripts

Gene Model

Pathway

PPI

Paralog

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.