EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28473981	Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer.	Biomed Res Int	2017	Qi L	doi: 10.1155/2017/2769140
12646234	Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2.	Biochem Biophys Res Commun	2003 Mar 21	Patra SK	-
23331011	Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin.	Curr Mol Med	2013 Mar	Xu J	-
18668384	Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population.	Biomarkers	2008 Sep	Liu H	doi: 10.1080/13547500802168031 .
18445260	Proteomic analysis of differential proteins in pancreatic carcinomas: Effects of MBD1 knock-down by stable RNA interference.	BMC Cancer	2008 Apr 29	Liu C	doi: 10.1186/1471-2407-8-121.
18666890	Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.	Biosci Rep	2008 Dec	Yaqinuddin A	doi: 10.1042/BSR20080032.
23588667	Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair.	Int J Oncol	2013 Jun	Xu J	doi: 10.3892/ijo.2013.1901
30487699	Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.	World J Gastroenterol	2018 Nov 21	Xu WY	doi: 10.3748/wjg.v24.i43.4893.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr18	50269730	3'UTR	novel		0.36
BLCA	chr18	50274258	In_Frame_Del	novel	F355_D358del	0.14
BLCA	chr18	50277115	Missense_Mutation	novel	G67D	0.73	MBD
BLCA	chr18	50275650	Frame_Shift_Del	novel	*R248Afs74**	0.4
BLCA	chr18	50275669	Frame_Shift_Del	novel	*I242Sfs80**	0.14
BLCA	chr18	50272907	Missense_Mutation	NA	E545Q	0.19
BLCA	chr18	50274203	Missense_Mutation	NA	C377R	0.23
BLCA	chr18	50271467	Splice_Site	novel		0.28
BLCA	chr18	50274302	Missense_Mutation	novel	C344S	0.49
BLCA	chr18	50272952	Missense_Mutation	novel	V530I	0.43
BLCA	chr18	50273471	Nonsense_Mutation	novel	E483*	0.33
BLCA	chr18	50274239	In_Frame_Del	novel	K359_G364del	0.24
BLCA	chr18	50270019	Intron	novel		0.35
BLCA	chr18	50276998	Missense_Mutation	novel	A76T	0.6
BRCA	chr18	50272948	Frame_Shift_Del	NA	*D531Afs7**	0.22
BRCA	chr18	50270073	Intron	NA		0.3
BRCA	chr18	50275858	Missense_Mutation	NA	R214C	0.32
BRCA	chr18	50274261	Silent	rs115570375	C357C	0.26
BRCA	chr18	50269500	3'UTR	novel		0.33
BRCA	chr18	50274246	Silent	NA	F362F	0.21
BRCA	chr18	50276682	Missense_Mutation	rs545375854	T152M	0.33
BRCA	chr18	50274245	Missense_Mutation	NA	G363R	0.26
CESC	chr18	50277129	Silent	rs772372557	F62F	0.44
CESC	chr18	50275423	Intron	novel		0.48
CESC	chr18	50275669	Frame_Shift_Del	novel	*I242Sfs80**	0.52
CESC	chr18	50273783	Frame_Shift_Ins	novel	*S410Gfs47**	0.05
CESC	chr18	50273784	Frame_Shift_Ins	novel	*P409Hfs19**	0.02
CESC	chr18	50275882	Missense_Mutation	novel	L206M	0.13
CESC	chr18	50269504	3'UTR	novel		0.41
CESC	chr18	50273728	Missense_Mutation	rs775229161	R428C	0.51
CESC	chr18	50275952	Silent	novel	C182C	0.37
CESC	chr18	50276927	Missense_Mutation	novel	Q99H	0.39
CESC	chr18	50279938	Missense_Mutation	novel	E19K	0.38	MBD
COAD	chr18	50275707	Missense_Mutation	rs771787035	R229W	0.73
COAD	chr18	50273410	Missense_Mutation	NA	A503V	0.33
COAD	chr18	50275635	Missense_Mutation	NA	R253C	0.08
COAD	chr18	50274295	Missense_Mutation	NA	R346Q	0.49
COAD	chr18	50273437	Missense_Mutation	novel	A494V	0.1
COAD	chr18	50276713	Frame_Shift_Del	NA	*D143Wfs29**	0.25
COAD	chr18	50274312	Silent	NA	A340A	0.64
COAD	chr18	50274209	Missense_Mutation	NA	R375C	0.27
COAD	chr18	50276398	Missense_Mutation	NA	R166W	0.26
COAD	chr18	50276397	Missense_Mutation	novel	R166Q	0.07
COAD	chr18	50275650	Missense_Mutation	NA	R248C	0.6
COAD	chr18	50274326	Missense_Mutation	NA	R336C	0.14
COAD	chr18	50271378	Intron	novel		0.32
COAD	chr18	50269602	3'UTR	novel		0.08
COAD	chr18	50273707	Missense_Mutation	NA	T435A	0.36
COAD	chr18	50277128	Missense_Mutation	NA	D63N	0.05	MBD
COAD	chr18	50275027	Missense_Mutation	NA	P310S	0.24
COAD	chr18	50269676	3'UTR	novel		0.31
DLBC	chr18	50272727	Silent	rs759306269	I576I	0.25
ESCA	chr18	50269573	3'UTR	novel		0.09
GBM	chr18	50277090	Splice_Region	NA	K75K	0.31
GBM	chr18	50273750	Silent	novel	T420T	0.62
GBM	chr18	50275683	Missense_Mutation	novel	C237G	0.37
GBM	chr18	50276996	Splice_Region	novel	A76A	0.46
GBM	chr18	50269573	3'UTR	novel		0.09
GBM	chr18	50269764	3'UTR	NA		0.09
GBM	chr18	50269573	3'UTR	novel		0.2
GBM	chr18	50274190	Missense_Mutation	novel	A381V	0.39
GBM	chr18	50274335	Missense_Mutation	novel	R333W	0.18
GBM	chr18	50276388	Missense_Mutation	novel	R169I	0.26
GBM	chr18	50271337	Intron	novel		0.09
GBM	chr18	50269689	3'UTR	novel		0.12
HNSC	chr18	50279882	Splice_Site	rs765681778	X37_splice	0.25
HNSC	chr18	50273843	Frame_Shift_Ins	novel	*W390Sfs33**	0.39
HNSC	chr18	50277108	Missense_Mutation	novel	L69F	0.19
HNSC	chr18	50273601	Missense_Mutation	rs199727558	P470L	0.46
KIRC	chr18	50272857	Silent	NA	P561P	0.24
KIRC	chr18	50273612	Silent	novel	P466P	0.34
KIRC	chr18	50277174	Silent	NA	V47V	0.24
KIRP	chr18	50275634	Missense_Mutation	rs759614155	R253H	0.34
LAML	chr18	50273402	Nonsense_Mutation	novel	Q506*	0.1
LAML	chr18	50269640	3'UTR	novel		0.4
LGG	chr18	50274227	Missense_Mutation	NA	R369C	0.11
LIHC	chr18	50275398	Intron	rs372009396		0.68
LIHC	chr18	50274258	In_Frame_Del	novel	F355_D358del	0.25
LIHC	chr18	50269945	Intron	novel		0.62
LIHC	chr18	50273686	Nonsense_Mutation	NA	E442*	0.32
LIHC	chr18	50276998	Missense_Mutation	NA	A76S	0.21
LUAD	chr18	50272843	Missense_Mutation	novel	G566E	0.07
LUAD	chr18	50269991	Intron	novel		0.11
LUAD	chr18	50273649	Missense_Mutation	NA	T454S	0.33
LUAD	chr18	50280018	Splice_Site	novel		0.27
LUAD	chr18	50273865	Splice_Site	NA	X383_splice	0.53
LUAD	chr18	50273396	Nonsense_Mutation	NA	E508*	0.29
LUAD	chr18	50273616	In_Frame_Ins	novel	S465delinsTR	0.07
LUAD	chr18	50270036	Intron	novel		0.31
LUAD	chr18	50269698	3'UTR	novel		0.17
LUAD	chr18	50276910	Frame_Shift_Del	novel	S104*	0.06
LUAD	chr18	50274242	Missense_Mutation	NA	G364C	0.47
LUAD	chr18	50276967	Frame_Shift_Del	novel	*R86Qfs99**	0.38
LUAD	chr18	50275974	Frame_Shift_Del	novel	*G175Afs10**	0.13
LUAD	chr18	50275926	Missense_Mutation	NA	C191F	0.5
LUAD	chr18	50275597	Splice_Region	novel		0.27
LUAD	chr18	50275676	Missense_Mutation	novel	H239L	0.09
LUAD	chr18	50275205	Missense_Mutation	NA	M278T	0.28
LUAD	chr18	50277154	Missense_Mutation	novel	G54D	0.27	MBD
LUSC	chr18	50275129	Splice_Region	rs759943579	P303P	0.23
LUSC	chr18	50273561	Splice_Region	novel		0.17
LUSC	chr18	50275724	Missense_Mutation	rs759684535	R223Q	0.25
LUSC	chr18	50275130	Missense_Mutation	rs115426299	P303L	0.21
LUSC	chr18	50274994	Missense_Mutation	NA	V321I	0.15
LUSC	chr18	50272926	Silent	NA	K538K	0.39
LUSC	chr18	50273358	Silent	novel	V520V	0.22
LUSC	chr18	50269781	3'UTR	novel		0.3
LUSC	chr18	50273772	Missense_Mutation	novel	R413L	0.38
LUSC	chr18	50274982	Missense_Mutation	novel	E325K	0.45
LUSC	chr18	50276856	Missense_Mutation	novel	A123V	0.41
LUSC	chr18	50274226	Missense_Mutation	novel	R369P	0.28
LUSC	chr18	50279946	Missense_Mutation	novel	K16M	0.13	MBD
LUSC	chr18	50279951	Silent	novel	G14G	0.35
LUSC	chr18	50273398	Missense_Mutation	novel	D507V	0.35
OV	chr18	50270019	Intron	novel		0.07
OV	chr18	50276915	Silent	NA	Q103Q	0.24
OV	chr18	50269738	3'UTR	novel		0.07
OV	chr18	50275915	Missense_Mutation	novel	L195F	0.13
OV	chr18	50270079	Intron	novel		0.05
OV	chr18	50273441	Missense_Mutation	rs774182305	V493M	0.78
OV	chr18	50272838	Frame_Shift_Ins	novel	*A568Sfs34**	0.05
OV	chr18	50273799	Missense_Mutation	rs769115388	R404H	0.21
PAAD	chr18	50271537	Splice_Site	novel	X593_splice	0.39
PAAD	chr18	50279940	Missense_Mutation	rs755717520	R18H	0.15	MBD
PRAD	chr18	50275025	Silent	novel	P310P	0.16
PRAD	chr18	50273410	Missense_Mutation	NA	A503V	0.17
PRAD	chr18	50279891	Frame_Shift_Del	novel	*Y34Lfs14**	0.44	MBD
PRAD	chr18	50272909	Frame_Shift_Del	novel	*P544Qfs29**	0.09
PRAD	chr18	50279889	Frame_Shift_Ins	novel	*Y35Lfs14**	0.5	MBD
READ	chr18	50269945	Intron	novel		0.3
READ	chr18	50269428	3'UTR	novel		0.21
READ	chr18	50275614	Nonsense_Mutation	NA	R260*	0.27
READ	chr18	50269619	3'UTR	novel		0.39
SARC	chr18	50270043	Intron	novel		0.24
SARC	chr18	50271397	Intron	novel		0.18
SARC	chr18	50273852	Silent	novel	L386L	0.45
SKCM	chr18	50269896	Intron	novel		0.17
SKCM	chr18	50277095	Missense_Mutation	novel	P74S	0.28
SKCM	chr18	50277096	Silent	NA	A73A	0.24
SKCM	chr18	50274246	Silent	NA	F362F	0.24
SKCM	chr18	50273698	Missense_Mutation	novel	P438S	0.43
SKCM	chr18	50275188	Missense_Mutation	NA	P284S	0.58
SKCM	chr18	50277204	Splice_Region	novel	S37S	0.25
SKCM	chr18	50275187	Missense_Mutation	NA	P284L	0.08
SKCM	chr18	50275392	Intron	rs749813772		0.62
STAD	chr18	50274227	Missense_Mutation	NA	R369C	0.31
STAD	chr18	50276701	Nonsense_Mutation	novel	Q146*	0.19
STAD	chr18	50269767	3'UTR	rs140260782		0.36
STAD	chr18	50276830	Splice_Site	NA	X131_splice	0.22
STAD	chr18	50276660	Splice_Site	NA	X159_splice	0.41
STAD	chr18	50271522	Frame_Shift_Del	NA	*K599Nfs66**	0.28
STAD	chr18	50275649	Missense_Mutation	rs376154307	R248H	0.25
STAD	chr18	50275707	Missense_Mutation	rs771787035	R229W	0.21
STAD	chr18	50272872	Silent	rs765543918	A556A	0.44
STAD	chr18	50273624	Silent	rs750544888	G462G	0.44
STAD	chr18	50276683	Frame_Shift_Del	novel	*T152Rfs33**	0.39
STAD	chr18	50273742	Missense_Mutation	NA	P423L	0.46
STAD	chr18	50272874	Missense_Mutation	novel	A556T	0.41
STAD	chr18	50273707	Missense_Mutation	NA	T435A	0.24
STAD	chr18	50269930	Intron	novel		0.19
STAD	chr18	50274296	Missense_Mutation	NA	R346W	0.2
THCA	chr18	50276842	Missense_Mutation	NA	P128S	0.27
THYM	chr18	50267491	3'Flank	novel		0.13
UCEC	chr18	50279938	Missense_Mutation	novel	E19K	0.2	MBD
UCEC	chr18	50273362	Missense_Mutation	NA	P519L	0.04
UCEC	chr18	50269509	3'UTR	novel		0.22
UCEC	chr18	50274261	Silent	rs115570375	C357C	0.11
UCEC	chr18	50275635	Missense_Mutation	NA	R253C	0.53
UCEC	chr18	50273379	Silent	novel	T513T	0.43
UCEC	chr18	50273369	Missense_Mutation	novel	T517P	0.14
UCEC	chr18	50269637	3'UTR	novel		0.38
UCEC	chr18	50279938	Missense_Mutation	novel	E19K	0.11	MBD
UCEC	chr18	50275230	Missense_Mutation	rs573408638	R270C	0.35
UCEC	chr18	50276991	Missense_Mutation	NA	P78L	0.45
UCEC	chr18	50276665	Nonsense_Mutation	rs758351481	R158*	0.29
UCEC	chr18	50276862	Missense_Mutation	novel	D121V	0.36
UCEC	chr18	50271333	Intron	novel		0.16
UCEC	chr18	50277129	Silent	rs772372557	F62F	0.27
UCEC	chr18	50269492	3'UTR	novel		0.49
UCEC	chr18	50273672	Silent	novel	G446G	0.43
UCEC	chr18	50274261	Silent	rs115570375	C357C	0.37
UCEC	chr18	50276665	Nonsense_Mutation	rs758351481	R158*	0.27
UCEC	chr18	50269937	Intron	novel		0.12
UCEC	chr18	50271418	Intron	novel		0.04
UCEC	chr18	50279939	Silent	NA	R18R	0.18
UCEC	chr18	50275725	Nonsense_Mutation	novel	R223*	0.2
UCEC	chr18	50279929	Missense_Mutation	rs780948760	R22C	0.18	MBD
UCEC	chr18	50279892	Missense_Mutation	novel	Y34C	0.23	MBD
UCEC	chr18	50271296	Intron	novel		0.59
UCEC	chr18	50279944	Missense_Mutation	NA	R17C	0.31	MBD
UCEC	chr18	50270042	Intron	novel		0.34
UCEC	chr18	50273449	Missense_Mutation	novel	S490I	0.49
UCEC	chr18	50274982	Missense_Mutation	novel	E325K	0.53
UCEC	chr18	50269593	3'UTR	novel		0.3
UCEC	chr18	50276397	Missense_Mutation	novel	R166Q	0.31
UCEC	chr18	50269741	3'UTR	rs753755162		0.31
UCEC	chr18	50275176	Missense_Mutation	novel	P288S	0.51
UCEC	chr18	50275725	Nonsense_Mutation	novel	R223*	0.38
UCEC	chr18	50272708	Missense_Mutation	NA	R583C	0.29
UCEC	chr18	50269681	3'UTR	novel		0.72
UCEC	chr18	50274296	Missense_Mutation	NA	R346W	0.62
UCEC	chr18	50276665	Nonsense_Mutation	rs758351481	R158*	0.62
UCEC	chr18	50273565	Missense_Mutation	novel	Q482R	0.39
UCEC	chr18	50269740	3'UTR	rs779457420		0.42
UCEC	chr18	50273360	Missense_Mutation	rs767264726	V520I	0.2
UCEC	chr18	50279940	Missense_Mutation	rs755717520	R18H	0.5	MBD
UCEC	chr18	50276376	Splice_Site	novel	X172_splice	0.5
UCEC	chr18	50269945	Intron	novel		0.38
UCEC	chr18	50275981	Missense_Mutation	novel	R173C	0.35
UCEC	chr18	50277137	Missense_Mutation	novel	T60A	0.31	MBD
UCEC	chr18	50279899	Missense_Mutation	novel	D32N	0.28	MBD
UCEC	chr18	50274227	Missense_Mutation	NA	R369C	0.33
UCEC	chr18	50271539	Missense_Mutation	novel	S594P	0.08
UCEC	chr18	50273624	Silent	rs750544888	G462G	0.47
UCEC	chr18	50275385	Intron	novel		0.52
UCEC	chr18	50269896	Intron	novel		0.21
UCEC	chr18	50271326	Intron	novel		0.38
UCEC	chr18	50275706	Missense_Mutation	NA	R229L	0.51
UCEC	chr18	50270030	Intron	NA		0.27
UCEC	chr18	50277134	Missense_Mutation	NA	L61I	0.21	MBD
UCEC	chr18	50273410	Missense_Mutation	NA	A503V	0.45
UCEC	chr18	50274246	Silent	NA	F362F	0.37
UCEC	chr18	50279970	Missense_Mutation	novel	C8Y	0.21	MBD
UCEC	chr18	50279928	Missense_Mutation	NA	R22H	0.27	MBD
UCEC	chr18	50271522	Frame_Shift_Del	NA	*K599Nfs66**	0.31
UCEC	chr18	50267454	3'Flank	novel		0.45
UCEC	chr18	50273349	Silent	novel	P523P	0.37
UCEC	chr18	50275930	Frame_Shift_Del	novel	*A190Pfs132**	0.5
UCEC	chr18	50267433	3'Flank	novel		0.67
UCEC	chr18	50275864	Missense_Mutation	rs777428957	R212W	0.55
UCEC	chr18	50275936	Missense_Mutation	NA	C188S	0.47
UCEC	chr18	50279929	Missense_Mutation	rs780948760	R22C	0.44	MBD
UCEC	chr18	50274227	Missense_Mutation	NA	R369C	0.45
UCEC	chr18	50274209	Missense_Mutation	NA	R375C	0.59
UCEC	chr18	50275621	Nonsense_Mutation	novel	C257*	0.35
UCEC	chr18	50275850	Silent	NA	L216L	0.3
UCEC	chr18	50276388	Missense_Mutation	NA	R169K	0.31
UCEC	chr18	50279929	Missense_Mutation	rs780948760	R22C	0.34	MBD
UCEC	chr18	50271500	3'UTR	novel		0.19
UCEC	chr18	50272708	Missense_Mutation	NA	R583C	0.45
UCEC	chr18	50273813	Silent	rs200586077	S399S	0.39
UCEC	chr18	50274293	Missense_Mutation	novel	R347W	0.38
UCEC	chr18	50275130	Missense_Mutation	rs115426299	P303L	0.59
UCEC	chr18	50275230	Missense_Mutation	rs573408638	R270C	0.27
UCEC	chr18	50275687	Missense_Mutation	novel	E235D	0.46
UCEC	chr18	50276682	Missense_Mutation	rs545375854	T152M	0.13
UCEC	chr18	50273694	Missense_Mutation	rs748711867	T439M	0.34
UCEC	chr18	50275229	Missense_Mutation	rs750294772	R270H	0.22
UCEC	chr18	50275236	Frame_Shift_Ins	novel	*A268Cfs8**	0.35
UCEC	chr18	50274227	Missense_Mutation	NA	R369C	0.37
UCEC	chr18	50275615	Silent	novel	Q259Q	0.45
UCEC	chr18	50269433	3'UTR	novel		0.28
UCS	chr18	50270049	Intron	novel		0.07
UCS	chr18	50273605	Missense_Mutation	novel	V469L	0.51

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3848	4.5185e-08
DLBC	DEL	0.0625	0.15679
LIHC	DEL	0.2378	0.019373
LUAD	DEL	0.3973	1.1082e-09
PAAD	DEL	0.5109	0.050455
READ	DEL	0.8545	0.20625
UCEC	DEL	0.141	0.006131
UCS	DEL	0.375	0.0031922

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0035	Kaplan-Meier Survival Analysis
MESO	0.038	Kaplan-Meier Survival Analysis
ACC	0.0052	Kaplan-Meier Survival Analysis
PRAD	0.0012	Kaplan-Meier Survival Analysis
KIRP	0.01	Kaplan-Meier Survival Analysis
PAAD	0.012	Kaplan-Meier Survival Analysis
PCPG	0.019	Kaplan-Meier Survival Analysis
UCEC	0.0059	Kaplan-Meier Survival Analysis
LIHC	0.0023	Kaplan-Meier Survival Analysis
CHOL	0.043	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000141644 (Gene tree)
Gene ID: 4152
Gene Symbol: MBD1
Alias: PCM1|CXXC3
Full Name: methyl-CpG binding domain protein 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 15,152 bases
Position: chr18:50,266,623-50,281,774
Accession: 6916
Summary: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000468042	MBD	PF01429.19	8.6e-16	1	1
ENSP00000381508	MBD	PF01429.19	8.7e-16	1	1
ENSP00000381502	MBD	PF01429.19	9.4e-16	1	1
ENSP00000465923	MBD	PF01429.19	9.8e-16	1	1
ENSP00000405268	MBD	PF01429.19	9.9e-16	1	1
ENSP00000468430	MBD	PF01429.19	9.9e-16	1	1
ENSP00000339546	MBD	PF01429.19	1e-15	1	1
ENSP00000269469	MBD	PF01429.19	1e-15	1	1
ENSP00000466092	MBD	PF01429.19	1e-15	1	1
ENSP00000269471	MBD	PF01429.19	1.1e-15	1	1
ENSP00000467763	MBD	PF01429.19	1.1e-15	1	1
ENSP00000285102	MBD	PF01429.19	1.1e-15	1	1
ENSP00000381506	MBD	PF01429.19	1.1e-15	1	1
ENSP00000269468	MBD	PF01429.19	1.2e-15	1	1
ENSP00000372407	MBD	PF01429.19	1.2e-15	1	1
ENSP00000467017	MBD	PF01429.19	1.2e-15	1	1
ENSP00000468785	MBD	PF01429.19	1.3e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18666890	Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.	Biosci Rep	2008 Dec	Yaqinuddin A	doi: 10.1042/BSR20080032.
24297921	H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1.	Proc Natl Acad Sci U S A	2013 Dec 17	Monnier P	doi: 10.1073/pnas.1310201110
16052033	Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus.	Nucleic Acids Res	2005 Jul 28	Auriol E	-
17274975	Time-lapse and retrospective analysis of DNA methylation in mouse preimplantation embryos by live cell imaging.	Dev Biol	2007 Apr 1	Yamazaki T	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000339998	MBD1-203	2956	-	ENSP00000339546	550 (aa)	-	Q9UIS9
ENST00000353909	MBD1-205	2820	-	ENSP00000269469	556 (aa)	-	Q9UIS9
ENST00000591416	MBD1-224	4905	XM_005258271	ENSP00000467017	605 (aa)	XP_005258328	Q9UIS9
ENST00000590208	MBD1-222	2913	XM_006722456	ENSP00000468785	655 (aa)	XP_006722519	Q9UIS9
ENST00000269468	MBD1-201	3259	XM_017025760	ENSP00000269468	605 (aa)	XP_016881249	Q9UIS9
ENST00000589758	MBD1-220	385	-	-	- (aa)	-	-
ENST00000398495	MBD1-209	2178	XM_017025766	ENSP00000381508	566 (aa)	XP_016881255	A0A0A0MS90
ENST00000398493	MBD1-208	1845	XM_017025768	ENSP00000381506	549 (aa)	XP_016881257	Q9UIS9
ENST00000586118	MBD1-213	1012	-	-	- (aa)	-	-
ENST00000590215	MBD1-223	749	-	ENSP00000464823	44 (aa)	-	K7EIN3
ENST00000382948	MBD1-206	2434	-	ENSP00000372407	605 (aa)	-	Q9UIS9
ENST00000589541	MBD1-218	836	-	ENSP00000466806	240 (aa)	-	K7EN65
ENST00000586679	MBD1-214	533	-	-	- (aa)	-	-
ENST00000587605	MBD1-216	1945	XM_011526006	ENSP00000468042	535 (aa)	XP_011524308	Q9UIS9
ENST00000592060	MBD1-227	1952	-	ENSP00000467606	416 (aa)	-	K7EPZ6
ENST00000585672	MBD1-212	2532	XM_017025755	ENSP00000466092	567 (aa)	XP_016881244	Q9UIS9
ENST00000589867	MBD1-221	673	-	-	- (aa)	-	-
ENST00000457839	MBD1-210	2473	XM_011525993	ENSP00000405268	630 (aa)	XP_011524295	Q9UIS9
ENST00000269471	MBD1-202	2980	-	ENSP00000269471	586 (aa)	-	Q9UIS9
ENST00000591661	MBD1-226	482	-	-	- (aa)	-	-
ENST00000589733	MBD1-219	767	-	ENSP00000466429	256 (aa)	-	K7EMA9
ENST00000586884	MBD1-215	514	-	-	- (aa)	-	-
ENST00000588937	MBD1-217	1761	-	ENSP00000467763	586 (aa)	-	Q9UIS9
ENST00000585595	MBD1-211	2179	-	ENSP00000468430	630 (aa)	-	Q9UIS9
ENST00000591535	MBD1-225	1611	-	ENSP00000465923	536 (aa)	-	Q9UIS9
ENST00000347968	MBD1-204	3091	-	ENSP00000285102	549 (aa)	-	Q9UIS9
ENST00000398488	MBD1-207	1512	XM_017025775	ENSP00000381502	503 (aa)	XP_016881264	Q9UIS9

Gene Model

Click here to download 's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141644's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141644	MBD1	100	87.658	ENSAMEG00000000238	MBD1	96	87.025	Ailuropoda_melanoleuca
ENSG00000141644	MBD1	80	68.571	ENSACAG00000006091	-	100	45.521	Anolis_carolinensis
ENSG00000141644	MBD1	100	96.508	ENSANAG00000036253	MBD1	100	96.508	Aotus_nancymaae
ENSG00000141644	MBD1	99	92.466	ENSBTAG00000003801	MBD1	100	86.529	Bos_taurus
ENSG00000141644	MBD1	100	96.641	ENSCJAG00000004959	MBD1	100	96.641	Callithrix_jacchus
ENSG00000141644	MBD1	99	95.420	ENSCAFG00000018928	MBD1	96	87.797	Canis_familiaris
ENSG00000141644	MBD1	99	86.196	ENSCAFG00020024272	MBD1	97	86.998	Canis_lupus_dingo
ENSG00000141644	MBD1	99	92.517	ENSCHIG00000021134	MBD1	100	86.529	Capra_hircus
ENSG00000141644	MBD1	100	91.145	ENSTSYG00000000509	MBD1	100	91.145	Carlito_syrichta
ENSG00000141644	MBD1	82	97.222	ENSCAPG00000015782	MBD1	96	71.376	Cavia_aperea
ENSG00000141644	MBD1	82	97.222	ENSCPOG00000001671	MBD1	100	73.957	Cavia_porcellus
ENSG00000141644	MBD1	99	97.333	ENSCCAG00000034600	MBD1	100	94.351	Cebus_capucinus
ENSG00000141644	MBD1	100	99.524	ENSCATG00000029959	MBD1	100	99.524	Cercocebus_atys
ENSG00000141644	MBD1	100	85.397	ENSCLAG00000007457	MBD1	89	85.397	Chinchilla_lanigera
ENSG00000141644	MBD1	100	99.835	ENSCSAG00000018070	MBD1	100	99.835	Chlorocebus_sabaeus
ENSG00000141644	MBD1	100	99.524	ENSCANG00000033425	MBD1	100	99.524	Colobus_angolensis_palliatus
ENSG00000141644	MBD1	100	76.524	ENSCGRG00001014843	Mbd1	100	74.877	Cricetulus_griseus_chok1gshd
ENSG00000141644	MBD1	80	85.714	ENSCGRG00000014135	Mbd1	84	79.310	Cricetulus_griseus_crigri
ENSG00000141644	MBD1	80	60.000	ENSDARG00000075952	mbd2	51	54.286	Danio_rerio
ENSG00000141644	MBD1	100	82.250	ENSDNOG00000015998	MBD1	100	83.518	Dasypus_novemcinctus
ENSG00000141644	MBD1	99	77.860	ENSDORG00000013917	Mbd1	97	78.659	Dipodomys_ordii
ENSG00000141644	MBD1	99	92.708	ENSEASG00005003857	MBD1	100	88.280	Equus_asinus_asinus
ENSG00000141644	MBD1	99	91.892	ENSECAG00000011497	MBD1	80	88.138	Equus_caballus
ENSG00000141644	MBD1	100	88.291	ENSFCAG00000015730	MBD1	100	87.816	Felis_catus
ENSG00000141644	MBD1	99	81.462	ENSFDAG00000011085	MBD1	96	80.182	Fukomys_damarensis
ENSG00000141644	MBD1	75	54.545	ENSGAFG00000008975	mbd1b	50	34.857	Gambusia_affinis
ENSG00000141644	MBD1	75	54.545	ENSGACG00000012106	-	58	33.983	Gasterosteus_aculeatus
ENSG00000141644	MBD1	82	77.778	ENSGAGG00000008206	-	52	49.466	Gopherus_agassizii
ENSG00000141644	MBD1	100	99.683	ENSGGOG00000016966	MBD1	100	99.683	Gorilla_gorilla
ENSG00000141644	MBD1	99	93.893	ENSHGLG00000008740	MBD1	100	85.785	Heterocephalus_glaber_female
ENSG00000141644	MBD1	93	86.943	ENSHGLG00100005198	MBD1	100	87.948	Heterocephalus_glaber_male
ENSG00000141644	MBD1	70	58.065	ENSIPUG00000015243	-	50	50.602	Ictalurus_punctatus
ENSG00000141644	MBD1	99	87.898	ENSSTOG00000007780	MBD1	100	83.902	Ictidomys_tridecemlineatus
ENSG00000141644	MBD1	98	78.889	ENSJJAG00000022859	Mbd1	96	78.889	Jaculus_jaculus
ENSG00000141644	MBD1	75	57.576	ENSKMAG00000020760	mbd1b	50	30.348	Kryptolebias_marmoratus
ENSG00000141644	MBD1	80	68.571	ENSLACG00000002414	-	51	65.079	Latimeria_chalumnae
ENSG00000141644	MBD1	99	75.954	ENSLAFG00000031328	MBD1	98	75.205	Loxodonta_africana
ENSG00000141644	MBD1	100	99.365	ENSMFAG00000026335	MBD1	100	99.365	Macaca_fascicularis
ENSG00000141644	MBD1	100	99.365	ENSMMUG00000009050	MBD1	100	99.365	Macaca_mulatta
ENSG00000141644	MBD1	100	99.365	ENSMNEG00000038822	MBD1	100	99.365	Macaca_nemestrina
ENSG00000141644	MBD1	100	99.683	ENSMLEG00000043121	MBD1	100	99.683	Mandrillus_leucophaeus
ENSG00000141644	MBD1	75	57.576	ENSMAMG00000023341	-	51	59.155	Mastacembelus_armatus
ENSG00000141644	MBD1	82	88.889	ENSMAUG00000021798	-	97	80.297	Mesocricetus_auratus
ENSG00000141644	MBD1	100	90.081	ENSMICG00000006414	MBD1	100	90.407	Microcebus_murinus
ENSG00000141644	MBD1	82	88.889	ENSMOCG00000011976	-	100	73.498	Microtus_ochrogaster
ENSG00000141644	MBD1	77	85.294	ENSMODG00000001286	-	58	44.330	Monodelphis_domestica
ENSG00000141644	MBD1	82	83.333	ENSMODG00000025004	-	100	58.712	Monodelphis_domestica
ENSG00000141644	MBD1	82	86.111	ENSMODG00000010534	-	99	58.304	Monodelphis_domestica
ENSG00000141644	MBD1	82	88.889	ENSMODG00000024864	-	100	52.652	Monodelphis_domestica
ENSG00000141644	MBD1	99	77.515	ENSMUSG00000024561	Mbd1	97	68.371	Mus_musculus
ENSG00000141644	MBD1	99	77.647	MGP_PahariEiJ_G0019128	Mbd1	100	68.362	Mus_pahari
ENSG00000141644	MBD1	99	77.515	MGP_SPRETEiJ_G0023304	Mbd1	99	69.643	Mus_spretus
ENSG00000141644	MBD1	100	87.184	ENSMPUG00000008843	MBD1	96	86.709	Mustela_putorius_furo
ENSG00000141644	MBD1	100	85.238	ENSMLUG00000008286	MBD1	96	85.238	Myotis_lucifugus
ENSG00000141644	MBD1	98	76.909	ENSNGAG00000011412	Mbd1	96	76.909	Nannospalax_galili
ENSG00000141644	MBD1	95	94.714	ENSNLEG00000032711	-	100	83.788	Nomascus_leucogenys
ENSG00000141644	MBD1	100	99.091	ENSNLEG00000011661	-	100	99.091	Nomascus_leucogenys
ENSG00000141644	MBD1	99	84.416	ENSOPRG00000007647	MBD1	100	74.876	Ochotona_princeps
ENSG00000141644	MBD1	99	82.440	ENSODEG00000018451	MBD1	97	82.440	Octodon_degus
ENSG00000141644	MBD1	82	86.111	ENSOANG00000014593	-	100	47.917	Ornithorhynchus_anatinus
ENSG00000141644	MBD1	99	90.840	ENSOCUG00000006554	MBD1	100	84.311	Oryctolagus_cuniculus
ENSG00000141644	MBD1	100	87.812	ENSOGAG00000003784	MBD1	96	87.812	Otolemur_garnettii
ENSG00000141644	MBD1	100	86.076	ENSOARG00000004218	MBD1	95	86.234	Ovis_aries
ENSG00000141644	MBD1	100	99.835	ENSPPAG00000038886	MBD1	100	99.835	Pan_paniscus
ENSG00000141644	MBD1	100	88.468	ENSPPRG00000021387	MBD1	100	87.975	Panthera_pardus
ENSG00000141644	MBD1	100	88.468	ENSPTIG00000021231	MBD1	100	87.975	Panthera_tigris_altaica
ENSG00000141644	MBD1	100	99.841	ENSPTRG00000010021	MBD1	100	99.841	Pan_troglodytes
ENSG00000141644	MBD1	100	99.695	ENSPANG00000010867	MBD1	100	99.695	Papio_anubis
ENSG00000141644	MBD1	82	88.889	ENSPEMG00000022630	Mbd1	97	66.607	Peromyscus_maniculatus_bairdii
ENSG00000141644	MBD1	82	91.667	ENSPCIG00000027937	-	84	45.234	Phascolarctos_cinereus
ENSG00000141644	MBD1	75	54.545	ENSPFOG00000007511	mbd1b	50	32.338	Poecilia_formosa
ENSG00000141644	MBD1	75	54.545	ENSPLAG00000021258	mbd1b	50	34.286	Poecilia_latipinna
ENSG00000141644	MBD1	75	54.545	ENSPMEG00000024145	mbd1b	50	32.338	Poecilia_mexicana
ENSG00000141644	MBD1	75	54.545	ENSPREG00000021805	mbd1b	50	34.286	Poecilia_reticulata
ENSG00000141644	MBD1	100	99.504	ENSPPYG00000009158	MBD1	91	99.504	Pongo_abelii
ENSG00000141644	MBD1	99	90.076	ENSPCAG00000001648	MBD1	93	86.260	Procavia_capensis
ENSG00000141644	MBD1	99	94.815	ENSPCOG00000012450	MBD1	100	92.739	Propithecus_coquereli
ENSG00000141644	MBD1	80	85.714	ENSRNOG00000024104	Mbd1	96	60.927	Rattus_norvegicus
ENSG00000141644	MBD1	100	99.281	ENSRBIG00000041294	MBD1	100	99.281	Rhinopithecus_bieti
ENSG00000141644	MBD1	100	99.365	ENSRROG00000032517	MBD1	100	99.365	Rhinopithecus_roxellana
ENSG00000141644	MBD1	100	95.878	ENSSBOG00000027169	MBD1	100	95.878	Saimiri_boliviensis_boliviensis
ENSG00000141644	MBD1	82	94.444	ENSSHAG00000003661	-	100	47.335	Sarcophilus_harrisii
ENSG00000141644	MBD1	75	51.515	ENSSPAG00000021447	mbd1b	51	34.359	Stegastes_partitus
ENSG00000141644	MBD1	99	92.667	ENSSSCG00000004516	MBD1	100	88.619	Sus_scrofa
ENSG00000141644	MBD1	75	54.545	ENSTRUG00000013422	mbd1b	50	31.026	Takifugu_rubripes
ENSG00000141644	MBD1	82	100.000	ENSTBEG00000012651	-	68	84.167	Tupaia_belangeri
ENSG00000141644	MBD1	99	90.506	ENSTTRG00000015523	MBD1	100	84.349	Tursiops_truncatus
ENSG00000141644	MBD1	93	91.901	ENSUAMG00000004752	MBD1	100	83.993	Ursus_americanus
ENSG00000141644	MBD1	99	92.715	ENSUMAG00000002947	MBD1	100	87.150	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	9774669.	TAS	Function
GO:0005515	protein binding	12665582.12711603.16432238.17066076.19498464.19666599.23275563.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10454587.	NAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0006346	methylation-dependent chromatin silencing	21873635.	IBA	Process
GO:0006366	transcription by RNA polymerase II	9774669.	TAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0008327	methyl-CpG binding	21873635.	IBA	Function
GO:0008327	methyl-CpG binding	25284789.	IDA	Function
GO:0008327	methyl-CpG binding	10454587.	NAS	Function
GO:0010385	double-stranded methylated DNA binding	11371345.	IDA	Function
GO:0016363	nuclear matrix	-	ISS	Component
GO:0016607	nuclear speck	-	ISS	Component
GO:0045892	negative regulation of transcription, DNA-templated	10454587.	NAS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Ortholog

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.