EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18651761Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer.J Proteome Res2008 SepZhao Ldoi: 10.1021/pr800271b
29059157EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.Oncogene2018 Feb 15Cho HJdoi: 10.1038/onc.2017.386
26416248RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression.Oncotarget2015 Oct 20Bozza WPdoi: 10.18632/oncotarget.5416.
21569526Genes associated with prognosis after surgery for malignant pleural mesothelioma promote tumor cell survival in vitro.BMC Cancer2011 May 13Gordon GJdoi: 10.1186/1471-2407-11-169.
21327297Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis.Mol Med2011Jiang Ldoi: 10.2119/molmed.2011.00008
2482041414-3-3?? promotes breast cancer invasion and metastasis by inhibiting RhoGDIα.Mol Cell Biol2014 JulXiao Y-
23922223RhoGDIα downregulates androgen receptor signaling in prostate cancer cells.Prostate2013 NovZhu Ydoi: 10.1002/pros.22615
21681778RhoGDIα suppresses growth and survival of prostate cancer cells.Prostate2012 MarZhu Ydoi: 10.1002/pros.21441
22668020Knockdown of RhoGDIα induces apoptosis and increases lung cancer cell chemosensitivity to paclitaxel.Neoplasma2012Rong Fdoi: 10.4149/neo_2012_070.
21447808Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.J Natl Cancer Inst2011 Apr 6Barone Idoi: 10.1093/jnci/djr058
22530308Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer.Pharmazie2012 MarYamashita T-
20043072Rho GDP dissociation inhibitor alpha expression correlates with the outcome of CMF treatment in invasive ductal breast cancer.Int J Oncol2010 FebRonneburg H-
22393046RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.J Biol Chem2012 Apr 20Yu Jdoi: 10.1074/jbc.M111.337469
28417530Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer.Cancer Sci2017 JulHuang Ddoi: 10.1111/cas.13259
29307615Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion.Cancer Lett2018 Mar 28Cho HJdoi: 10.1016/j.canlet.2018.01.002

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1781869784SilentnovelR49R0.95
BLCAchr17818688323'UTRnovel0.29
BLCAchr1781869229Missense_MutationnovelR120Q0.48
BLCAchr17818688363'UTRnovel0.31
BLCAchr1781869023Silentrs779427124Y156Y0.48
BLCAchr17818699345'UTRnovel0.19
BLCAchr17818688403'UTRnovel0.33
BRCAchr17818688113'UTRrs7789036620.37
BRCAchr1781869551Missense_MutationNAD89N0.5
BRCAchr1781868952Missense_Mutationrs764941554R180H0.05
CESCchr17818681383'UTRnovel0.21
CESCchr17818678413'UTRnovel0.34
CESCchr17818681053'UTRnovel0.39
CESCchr1781869369SilentnovelL104L0.16
CESCchr1781869856SilentNAV25V0.16
CESCchr1781869230Nonsense_Mutationrs587777553R120*0.57
COADchr1781869037Missense_MutationnovelR152W0.39
COADchr1781869617Missense_Mutationrs200283878V67I0.17
COADchr17818688113'UTRrs7789036620.4
COADchr17818688553'UTRnovel0.35
COADchr17818688113'UTRrs7789036620.52
COADchr17818687483'UTRrs7569859340.24
COADchr17818688623'UTRrs7547573700.38
COADchr1781869344Missense_MutationNAK113Q0.28
ESCAchr17818681683'UTRrs5636958560.61
GBMchr1781869194Missense_MutationnovelT132A0.24
GBMchr1781868904Missense_MutationNAL196R0.81
HNSCchr1781869872Frame_Shift_InsnovelE20Gfs*30.32
HNSCchr17818688103'UTRrs7571317630.42
HNSCchr1781868939Missense_MutationnovelD184E0.32
HNSCchr17818688513'UTRnovel0.2
KIRCchr1781869738Splice_Regionnovel0.2
KIRPchr1781869910SilentnovelT7T0.29
LIHCchr1781868960Missense_MutationNAI177M0.12
LUADchr1781869844SilentnovelP29P0.16
LUSCchr1781869890Missense_MutationnovelI14T0.36
LUSCchr1781869337Missense_Mutationrs775688385S115C0.12
PAADchr1781869229Missense_MutationnovelR120Q0.2
PAADchr1781869540Splice_SitenovelX92_splice0.16
PRADchr17818688333'UTRrs2020261970.6
SARCchr17818685733'UTRnovel0.58
SKCMchr1781869231Silentrs371966890N119N0.41
SKCMchr1781869217Missense_MutationNAS124F0.49
SKCMchr1781869892SilentNAQ13Q0.1
SKCMchr1781868912SilentnovelE193E0.14
STADchr17818688453'UTRrs10572830.17
STADchr17818688113'UTRrs7789036620.26
STADchr1781868891Missense_MutationNAK200N0.12
STADchr17818688443'UTRnovel0.31
STADchr1781869193Missense_MutationNAT132M0.16
STADchr1781869205Missense_MutationnovelY128C0.12
UCECchr17818678283'UTRnovel0.36
UCECchr1781869185Missense_MutationnovelK135E0.09
UCECchr1781869884Missense_MutationnovelA16V0.43
UCECchr1781869812Missense_MutationnovelE40G0.05
UCECchr1781869798Missense_MutationNAD45N0.21
UCECchr17818677683'UTRnovel0.64
UCECchr1781869038SilentnovelP151P0.28
UCECchr1781869393Missense_MutationnovelS96R0.21
UCECchr1781869176Missense_MutationNAK138E0.48
UCECchr17818678993'UTRnovel0.28
UCECchr1781869014Silentrs780341101L159L0.22
UCECchr1781868881Missense_MutationnovelD204N0.31
UCECchr17818683543'UTRnovel0.32
UCECchr1781869744Missense_Mutationrs752693120A63T0.38
UCECchr1781869193Missense_MutationNAT132M0.51
UCECchr17818682833'UTRrs1491625670.39
UCECchr17818683273'UTRnovel0.38
UCECchr1781869216SilentnovelS124S0.39
UVMchr1781869230Nonsense_Mutationrs587777553R120*0.51

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.39220.00012456
CESCDEL0.10510.00067839
KIRPAMP0.67010.14801
LGGAMP0.06631.52e-05
SARCAMP0.19840.032181
SKCMAMP0.28347.0388e-08
THCADEL0.0020.221
UVMAMP0.16250.054583

Survival Analysis
CancerP-value Q-value
ACC0.00011

Kaplan-Meier Survival Analysis

UCS0.027

Kaplan-Meier Survival Analysis

HNSC0.021

Kaplan-Meier Survival Analysis

SKCM0.0085

Kaplan-Meier Survival Analysis

LUSC0.0067

Kaplan-Meier Survival Analysis

BLCA0.015

Kaplan-Meier Survival Analysis

CESC0.031

Kaplan-Meier Survival Analysis

LAML0.034

Kaplan-Meier Survival Analysis

GBM0.015

Kaplan-Meier Survival Analysis

LIHC0.02

Kaplan-Meier Survival Analysis

LGG0.006

Kaplan-Meier Survival Analysis

LUAD0.029

Kaplan-Meier Survival Analysis

UVM0.0063

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000141522 (Gene tree)
Gene ID
396
Gene Symbol
ARHGDIA
Alias
RHOGDI|GDIA1
Full Name
Rho GDP dissociation inhibitor alpha
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
3,688 bases
Position
chr17:81,867,719-81,871,406
Accession
678
RBP type
non-canonical RBP
Summary
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
14583493Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.Cancer Res2003 Oct 15MacKeigan JP-
30973085Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.Neurol Res2019 JulMostafa DGdoi: 10.1080/01616412.2019.1596206
26761212Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.Oncotarget2016 Apr 12Lin Xdoi: 10.18632/oncotarget.6869.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000583791ARHGDIA-214351--- (aa)--
ENST00000580033ARHGDIA-206547-ENSP0000046353092 (aa)-J3KS60
ENST00000582984ARHGDIA-211823--- (aa)--
ENST00000581876ARHGDIA-208709-ENSP00000461956129 (aa)-J3KRE2
ENST00000578351ARHGDIA-204421-ENSP0000046232392 (aa)-J3KS60
ENST00000579121ARHGDIA-205637-ENSP00000462960193 (aa)-J3KTF8
ENST00000583111ARHGDIA-212574--- (aa)--
ENST00000584461ARHGDIA-217886-ENSP00000463939235 (aa)-J3QQX2
ENST00000582309ARHGDIA-209628--- (aa)--
ENST00000582520ARHGDIA-210245--- (aa)--
ENST00000541078ARHGDIA-2031517XM_011523574ENSP00000441348204 (aa)XP_011521876P52565
ENST00000580685ARHGDIA-2071201-ENSP00000464205204 (aa)-P52565
ENST00000583868ARHGDIA-215815-ENSP00000462209249 (aa)-J3KRY1
ENST00000583499ARHGDIA-213560--- (aa)--
ENST00000400721ARHGDIA-2021568-ENSP00000383556160 (aa)-P52565
ENST00000269321ARHGDIA-2011906-ENSP00000269321204 (aa)-P52565
ENST00000584397ARHGDIA-216622--- (aa)--
Gene Model
Click here to download ENSG00000141522's gene model file
Pathways
Pathway IDPathway NameSource
hsa04722Neurotrophin signaling pathwayKEGG
hsa04962Vasopressin-regulated water reabsorptionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141522's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000141522ARHGDIA100100.000ENSMUSG00000025132Arhgdia10097.059Mus_musculus
ENSG00000141522ARHGDIA8982.812ENSMUSG00000030220Arhgdib9975.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005094Rho GDP-dissociation inhibitor activity21873635.IBAFunction
GO:0005096GTPase activator activity-IEAFunction
GO:0005515protein binding10489445.11513578.17245428.20711218.21044950.21900206.22157745.25416956.25961457.27173435.30337686.IPIFunction
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton16130169.TASComponent
GO:0007162negative regulation of cell adhesion8262133.TASProcess
GO:0007266Rho protein signal transduction21873635.IBAProcess
GO:0016020membrane21873635.IBAComponent
GO:0035023regulation of Rho protein signal transduction8262133.IMPProcess
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0043547positive regulation of GTPase activity-IEAProcess
GO:0048365Rac GTPase binding21873635.IBAFunction
GO:0050771negative regulation of axonogenesis-TASProcess
GO:0050772positive regulation of axonogenesis-TASProcess
GO:0051056regulation of small GTPase mediated signal transduction-TASProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0071526semaphorin-plexin signaling pathway-ISSProcess
GO:2000249regulation of actin cytoskeleton reorganization8262133.IMPProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us