EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26078295	Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.	Mol Cancer Res	2015 Sep	Hensel J	doi: 10.1158/1541-7786.MCR-15-0130
26398880	miR-506 regulates breast cancer cell metastasis by targeting IQGAP1.	Int J Oncol	2015 Nov	Sun G	doi: 10.3892/ijo.2015.3161
23454766	IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.	J Clin Invest	2013 Mar	Liu C	doi: 10.1172/JCI63836
24800852	Targeted knockdown of IQGAP1 inhibits the progression of esophageal squamous cell carcinoma in vitro and in vivo.	PLoS One	2014 May 6	Wang XX	doi: 10.1371/journal.pone.0096501
20959410	IQGAP1 plays an important role in the invasiveness of thyroid cancer.	Clin Cancer Res	2010 Dec 15	Liu Z	doi: 10.1158/1078-0432.CCR-10-1627
25675045	IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.	Int J Gynecol Cancer	2015 May	Huang L	doi: 10.1097/IGC.0000000000000394.
27100492	Potential involvement of IQGAP1 in proliferation and metastasis of human pancreatic cancer.	Front Biosci (Landmark Ed)	2016 Jun 1	Jin Y	-
19856315	Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion.	Int J Cancer	2010 Jun 1	Hayashi H	doi: 10.1002/ijc.24987.
19036171	Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro.	J Exp Clin Cancer Res	2008 Nov 27	Dong PX	doi: 10.1186/1756-9966-27-77.
22483753	IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer.	Biochem Biophys Res Commun	2012 Apr 27	Yin N	doi: 10.1016/j.bbrc.2012.03.112
24103286	Overexpression of IQGAP1 in human pancreatic cancer.	Hepatobiliary Pancreat Dis Int	2013 Oct	Wang XX	-
25436461	Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer.	PLoS One	2014 Dec 1	Zhao H	doi: 10.1371/journal.pone.0113713
26046126	IQGAP1 modulates the proliferation and invasion of thyroid cancer cells in response to estrogen.	Int J Mol Med	2015 Aug	Meng D	doi: 10.3892/ijmm.2015.2232
27470543	MALAT1 promotes the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1.	Biomed Pharmacother	2016 Oct	Huang JK	doi: 10.1016/j.biopha.2016.05.039
21621326	Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway.	Cancer Lett	2011 Sep 28	Tang MC	doi: 10.1016/j.canlet.2011.05.001
21318219	Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.	Int J Oncol	2011 Apr	Zheng H	doi: 10.3892/ijo.2011.940
23145020	RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1.	PLoS One	2012	Wu Y	doi: 10.1371/journal.pone.0048917
28618949	IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.	Tumour Biol	2017 Jun	Zhao HY	doi: 10.1177/1010428317705769.
28739799	LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.	J Biol Chem	2017 Sep 8	Carmon KS	doi: 10.1074/jbc.M117.786798
26934121	Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression.	Oncotarget	2016 Apr 12	Dong P	doi: 10.18632/oncotarget.7754.
29779034	Ras GTPase-Activating-Like Protein IQGAP1 (IQGAP1) Promotes Breast Cancer Proliferation and Invasion and Correlates with Poor Clinical Outcomes.	Med Sci Monit	2018 May 20	Zeng F	doi: 10.12659/MSM.909916.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	90467590	In_Frame_Ins	novel		0.05
BLCA	chr15	90473751	Missense_Mutation	novel	Q796E	0.22
BLCA	chr15	90477153	Silent	novel	L1009L	0.33
BLCA	chr15	90482239	Silent	NA	L1171L	0.36
BLCA	chr15	90492620	Missense_Mutation	novel	L1513V	0.08
BLCA	chr15	90454446	Missense_Mutation	novel	M502I	0.28
BLCA	chr15	90433742	Silent	rs767016252	D138D	0.25
BLCA	chr15	90477114	Silent	novel	N996N	0.16
BLCA	chr15	90474588	Silent	novel	R893R	0.21
BLCA	chr15	90474589	Nonsense_Mutation	novel	E894*	0.22
BLCA	chr15	90477813	Missense_Mutation	novel	L1085F	0.57
BLCA	chr15	90476771	Frame_Shift_Del	novel	*K965Efs62**	0.36
BLCA	chr15	90477873	Nonsense_Mutation	novel	Q1105*	0.41
BLCA	chr15	90473926	Nonsense_Mutation	novel	R822*	0.05
BLCA	chr15	90426241	Missense_Mutation	rs770042259	Y96C	0.07
BLCA	chr15	90429595	Missense_Mutation	NA	G107S	0.33
BLCA	chr15	90452896	Silent	NA	L428L	0.33
BLCA	chr15	90482227	Silent	rs761144008	L1167L	0.28
BRCA	chr15	90426235	Frame_Shift_Del	NA	*K94Tfs22**	0.17
BRCA	chr15	90477787	Missense_Mutation	novel	V1076G	0.08
BRCA	chr15	90476692	Frame_Shift_Ins	NA	*N941Kfs2**	0.39
BRCA	chr15	90476722	Missense_Mutation	NA	M948I	0.6
BRCA	chr15	90500144	3'UTR	novel		0.11
BRCA	chr15	90440512	Silent	novel	I182I	0.09
BRCA	chr15	90466330	Silent	NA	L643L	0.32
BRCA	chr15	90472905	Silent	NA	L748L	0.25
BRCA	chr15	90476722	Missense_Mutation	NA	M948I	0.28
BRCA	chr15	90477875	Missense_Mutation	NA	Q1105H	0.27
BRCA	chr15	90483562	Missense_Mutation	NA	E1253K	0.24
BRCA	chr15	90487073	Nonsense_Mutation	novel	R1382*	0.07
CESC	chr15	90500114	3'UTR	rs144921710		0.1
CESC	chr15	90453181	Missense_Mutation	rs546591604	S459L	0.19
CESC	chr15	90491527	Silent	rs199804766	L1481L	0.21
CESC	chr15	90500100	Missense_Mutation	NA	G1656R	0.22
CESC	chr15	90440528	Missense_Mutation	NA	E188K	0.37
CESC	chr15	90500181	3'UTR	novel		0.35
CESC	chr15	90487577	Frame_Shift_Ins	novel	*E1415Vfs18**	0.25
CESC	chr15	90487579	Frame_Shift_Del	novel	*Q1416Kfs22**	0.25
CESC	chr15	90429636	Missense_Mutation	NA	L120F	0.43
CESC	chr15	90433786	Frame_Shift_Ins	novel	*H153Qfs24**	0.1
CESC	chr15	90467544	Frame_Shift_Del	novel	*P711Qfs22**	0.17
CESC	chr15	90449623	Missense_Mutation	NA	A381V	0.17
CESC	chr15	90466046	Missense_Mutation	NA	G608R	0.21
CESC	chr15	90453242	Silent	NA	L479L	0.48
CESC	chr15	90483529	Missense_Mutation	NA	L1242V	0.25
CESC	chr15	90443391	Splice_Region	novel		0.34
CESC	chr15	90474624	Missense_Mutation	NA	Q905H	0.11
COAD	chr15	90491541	Missense_Mutation	novel	A1486V	0.11
COAD	chr15	90452854	Silent	rs770596390	P414P	0.35
COAD	chr15	90483443	Missense_Mutation	NA	A1213V	0.21
COAD	chr15	90454543	Missense_Mutation	novel	E535K	0.16
COAD	chr15	90472905	Silent	NA	L748L	0.25
COAD	chr15	90456213	Silent	NA	L558L	0.29
COAD	chr15	90454480	Nonsense_Mutation	novel	E514*	0.32
COAD	chr15	90467490	Silent	novel	G692G	0.46
COAD	chr15	90500134	3'UTR	novel		0.39
COAD	chr15	90476693	Frame_Shift_Del	rs771739474	*N941Ifs8**	0.43
COAD	chr15	90483436	Missense_Mutation	rs535117997	L1211M	0.36
COAD	chr15	90473714	Splice_Site	novel	X784_splice	0.42
COAD	chr15	90390871	Missense_Mutation	NA	K51N	0.16
COAD	chr15	90486051	Missense_Mutation	novel	A1315T	0.2
COAD	chr15	90500012	Silent	rs778382730	Q1626Q	0.42
COAD	chr15	90477671	Silent	NA	K1037K	0.31
COAD	chr15	90492665	Frame_Shift_Del	NA	*S1529Afs10**	0.15
COAD	chr15	90484221	Missense_Mutation	rs763205486	R1264W	0.43
COAD	chr15	90441592	Missense_Mutation	rs753859958	M246V	0.17
COAD	chr15	90440612	Missense_Mutation	rs772573837	A216T	0.32
COAD	chr15	90494825	Missense_Mutation	NA	Q1581K	0.2
COAD	chr15	90426179	Frame_Shift_Ins	novel	*V76Kfs24**	0.08
COAD	chr15	90448688	In_Frame_Ins	novel	S343_D344insL	0.06
DLBC	chr15	90433754	Silent	novel	R142R	0.27
ESCA	chr15	90491498	Missense_Mutation	rs751120932	V1472M	0.13
ESCA	chr15	90388355	Missense_Mutation	novel	D5G	0.28
ESCA	chr15	90501969	3'UTR	novel		0.38
GBM	chr15	90426124	Missense_Mutation	novel	C57F	0.17
GBM	chr15	90454473	Missense_Mutation	novel	E511D	0.35
GBM	chr15	90473757	Missense_Mutation	rs762319697	R798W	0.36
GBM	chr15	90441572	Missense_Mutation	novel	A239G	0.06
GBM	chr15	90429650	Missense_Mutation	rs764973369	E125A	0.29
GBM	chr15	90483381	Nonsense_Mutation	novel	Y1192*	0.04
HNSC	chr15	90491398	Missense_Mutation	rs752418699	M1438I	0.11
HNSC	chr15	90486075	Missense_Mutation	novel	P1323A	0.3
HNSC	chr15	90486128	Silent	novel	L1340L	0.23
HNSC	chr15	90441545	Missense_Mutation	rs372323221	R230H	0.28
HNSC	chr15	90390804	Missense_Mutation	novel	E29V	0.09
HNSC	chr15	90390827	Frame_Shift_Ins	novel	*N38Efs5**	0.23
HNSC	chr15	90390829	Missense_Mutation	novel	Q37H	0.23
HNSC	chr15	90477730	Missense_Mutation	novel	S1057T	0.09
HNSC	chr15	90487036	Silent	NA	F1369F	0.14
HNSC	chr15	90439344	Missense_Mutation	novel	F160L	0.08
HNSC	chr15	90487040	Missense_Mutation	rs181919733	V1371M	0.09
HNSC	chr15	90497282	Nonsense_Mutation	novel	F1601_E1602delins*	0.27
HNSC	chr15	90492614	Missense_Mutation	novel	A1511S	0.1
HNSC	chr15	90500119	3'UTR	novel		0.63
HNSC	chr15	90483555	Silent	novel	I1250I	0.08
KICH	chr15	90487033	Frame_Shift_Del	novel	*F1369Efs14**	0.4
KIRC	chr15	90492587	Frame_Shift_Del	novel	*E1502Nfs2**	0.29
KIRC	chr15	90477777	Missense_Mutation	NA	A1073S	0.24
KIRC	chr15	90477778	Missense_Mutation	NA	A1073D	0.23
KIRC	chr15	90477681	Missense_Mutation	NA	I1041L	0.17
KIRC	chr15	90482212	Silent	novel	F1162F	0.19
KIRC	chr15	90491492	Nonsense_Mutation	novel	*G1470Efs4**	0.09
KIRC	chr15	90491494	Silent	novel	G1470G	0.05
KIRP	chr15	90474561	Silent	novel	Q884Q	0.52
KIRP	chr15	90466320	Missense_Mutation	NA	G640V	0.26
LAML	chr15	90454530	Frame_Shift_Del	novel	*V531Wfs10**	0.03
LAML	chr15	90441513	Silent	novel	A219A	0.14
LGG	chr15	90472958	Missense_Mutation	NA	R766Q	0.32
LGG	chr15	90390867	Missense_Mutation	rs745638782	A50V	0.38
LGG	chr15	90429590	Missense_Mutation	rs768861482	A105V	0.34
LGG	chr15	90452817	Missense_Mutation	novel	G402D	0.34
LGG	chr15	90482259	Missense_Mutation	novel	A1178V	0.26
LGG	chr15	90487074	Missense_Mutation	rs776564409	R1382Q	0.29
LGG	chr15	90500141	3'UTR	novel		0.33
LGG	chr15	90487499	Missense_Mutation	rs200349977	K1389E	0.22
LGG	chr15	90491357	Nonsense_Mutation	NA	Q1425*	0.14
LIHC	chr15	90443441	Silent	rs375134287	T292T	0.22
LIHC	chr15	90500044	Missense_Mutation	NA	D1637A	0.07
LIHC	chr15	90433780	Missense_Mutation	novel	C151S	0.31
LIHC	chr15	90474502	Missense_Mutation	NA	P865S	0.29
LIHC	chr15	90477709	Missense_Mutation	NA	T1050M	0.23
LIHC	chr15	90494772	Missense_Mutation	novel	Y1563C	0.38
LUAD	chr15	90452894	Missense_Mutation	novel	L428F	0.09
LUAD	chr15	90453162	Missense_Mutation	NA	A453S	0.08
LUAD	chr15	90482089	Silent	novel	V1153V	0.09
LUAD	chr15	90492561	Missense_Mutation	novel	R1493L	0.34
LUAD	chr15	90494780	Missense_Mutation	novel	A1566T	0.18
LUAD	chr15	90449629	Missense_Mutation	novel	Q383R	0.15
LUAD	chr15	90441514	Missense_Mutation	novel	A220S	0.15
LUAD	chr15	90492586	Silent	rs750054244	A1501A	0.13
LUAD	chr15	90388371	Silent	NA	L10L	0.21
LUAD	chr15	90477739	Missense_Mutation	NA	R1060L	0.05
LUAD	chr15	90443473	Splice_Site	novel	X303_splice	0.12
LUSC	chr15	90439391	Missense_Mutation	novel	D176V	0.29
LUSC	chr15	90491399	Missense_Mutation	novel	K1439Q	0.83
LUSC	chr15	90453142	Missense_Mutation	novel	T446I	0.23
LUSC	chr15	90487478	Intron	novel		0.37
LUSC	chr15	90484337	Silent	NA	I1302I	0.14
LUSC	chr15	90467544	Frame_Shift_Del	novel	*P711Qfs22**	0.66
LUSC	chr15	90456244	Nonsense_Mutation	NA	E569*	0.15
LUSC	chr15	90390825	Missense_Mutation	rs570821440	R36H	0.17
LUSC	chr15	90482085	Missense_Mutation	NA	S1152F	0.26
LUSC	chr15	90477684	Missense_Mutation	NA	Q1042E	0.09
LUSC	chr15	90483559	Missense_Mutation	novel	N1252D	0.24
LUSC	chr15	90466056	Missense_Mutation	novel	W611L	0.24
LUSC	chr15	90466057	Missense_Mutation	novel	W611C	0.24
LUSC	chr15	90486992	Missense_Mutation	novel	A1355S	0.56
LUSC	chr15	90494767	Silent	NA	L1561L	0.33
LUSC	chr15	90477137	Missense_Mutation	novel	S1004C	0.34
LUSC	chr15	90486987	Missense_Mutation	novel	K1353M	0.12
LUSC	chr15	90483391	Missense_Mutation	novel	M1196V	0.23
LUSC	chr15	90452900	Missense_Mutation	NA	Q430E	0.09
MESO	chr15	90500254	3'UTR	novel		0.29
OV	chr15	90476739	Missense_Mutation	NA	Q954R	0.88
OV	chr15	90486040	Missense_Mutation	NA	D1311G	0.23
OV	chr15	90500216	3'UTR	novel		0.07
PAAD	chr15	90474110	Missense_Mutation	novel	A851V	0.18
PAAD	chr15	90474112	Missense_Mutation	novel	R852W	0.11
PAAD	chr15	90388334	5'UTR	rs758934218		0.12
PRAD	chr15	90497338	Nonsense_Mutation	rs755073388	Q1620*	0.31
PRAD	chr15	90484248	Missense_Mutation	NA	P1273A	0.22
PRAD	chr15	90466369	Silent	novel	V656V	0.55
PRAD	chr15	90481993	Silent	rs757661342	A1121A	0.32
READ	chr15	90483555	Silent	NA	I1250I	0.22
READ	chr15	90476692	Frame_Shift_Ins	NA	*N941Kfs2**	0.26
READ	chr15	90433768	Missense_Mutation	novel	R147I	0.45
READ	chr15	90452780	Missense_Mutation	NA	A390T	0.37
READ	chr15	90492702	Missense_Mutation	novel	S1540I	0.47
READ	chr15	90449560	Missense_Mutation	NA	S360N	0.13
SARC	chr15	90390866	Missense_Mutation	novel	A50S	0.21
SARC	chr15	90448626	Missense_Mutation	novel	A323S	0.09
SARC	chr15	90484329	Missense_Mutation	novel	G1300S	0.53
SARC	chr15	90484330	Missense_Mutation	novel	G1300D	0.53
SARC	chr15	90494765	Missense_Mutation	novel	L1561M	0.08
SARC	chr15	90491443	Missense_Mutation	novel	Q1453H	0.15
SKCM	chr15	90456252	Silent	NA	V571V	0.39
SKCM	chr15	90473904	Silent	rs754652245	S814S	0.12
SKCM	chr15	90439357	Missense_Mutation	novel	A165T	0.65
SKCM	chr15	90473904	Silent	rs754652245	S814S	0.31
SKCM	chr15	90482212	Silent	novel	F1162F	0.3
SKCM	chr15	90500114	3'UTR	rs144921710		0.18
SKCM	chr15	90482075	Missense_Mutation	novel	I1149V	0.3
SKCM	chr15	90484247	Silent	NA	V1272V	0.41
SKCM	chr15	90483527	Missense_Mutation	novel	F1241Y	0.41
SKCM	chr15	90491352	Missense_Mutation	NA	A1423V	0.17
SKCM	chr15	90466063	Silent	NA	S613S	0.25
SKCM	chr15	90441583	Missense_Mutation	NA	P243S	0.12
SKCM	chr15	90487487	Splice_Region	novel		0.27
SKCM	chr15	90474085	Nonsense_Mutation	NA	Q843*	0.18
SKCM	chr15	90441515	Missense_Mutation	NA	A220V	0.13
SKCM	chr15	90484247	Silent	NA	V1272V	0.31
SKCM	chr15	90500162	3'UTR	novel		0.56
SKCM	chr15	90473904	Silent	rs754652245	S814S	0.64
SKCM	chr15	90441554	Missense_Mutation	NA	P233L	0.51
SKCM	chr15	90476757	Missense_Mutation	novel	A960V	0.4
SKCM	chr15	90473903	Missense_Mutation	novel	S814F	0.18
SKCM	chr15	90474097	Missense_Mutation	NA	R847W	0.33
SKCM	chr15	90441518	Missense_Mutation	NA	V221A	0.4
SKCM	chr15	90482235	Missense_Mutation	rs139658864	S1170L	0.47
STAD	chr15	90492613	Silent	novel	Y1510Y	0.51
STAD	chr15	90441649	Missense_Mutation	NA	A265T	0.3
STAD	chr15	90474098	Missense_Mutation	NA	R847Q	0.23
STAD	chr15	90494724	Missense_Mutation	NA	K1547R	0.12
STAD	chr15	90491391	Missense_Mutation	NA	D1436A	0.31
STAD	chr15	90494732	Missense_Mutation	NA	E1550K	0.13
STAD	chr15	90476770	Missense_Mutation	NA	E964D	0.4
STAD	chr15	90433762	Missense_Mutation	novel	M145T	0.29
STAD	chr15	90484340	Silent	novel	I1303I	0.32
STAD	chr15	90466423	Missense_Mutation	NA	K674N	0.11
STAD	chr15	90452823	Missense_Mutation	novel	A404V	0.45
STAD	chr15	90453251	Silent	NA	S482S	0.1
STAD	chr15	90473956	Missense_Mutation	NA	F832V	0.06
STAD	chr15	90466302	Missense_Mutation	novel	V634A	0.37
STAD	chr15	90476692	Frame_Shift_Ins	NA	*N941Kfs2**	0.27
STAD	chr15	90476693	Frame_Shift_Del	rs771739474	*N941Ifs8**	0.28
STAD	chr15	90492609	Missense_Mutation	NA	T1509I	0.26
STAD	chr15	90454523	Missense_Mutation	NA	V528G	0.38
STAD	chr15	90429657	Silent	NA	G127G	0.2
STAD	chr15	90441557	Missense_Mutation	NA	A234V	0.18
STAD	chr15	90484221	Missense_Mutation	rs763205486	R1264W	0.23
UCEC	chr15	90477886	Missense_Mutation	novel	A1109G	0.32
UCEC	chr15	90483381	Frame_Shift_Del	novel	*Y1193Ifs4**	0.43
UCEC	chr15	90487036	Silent	NA	F1369F	0.33
UCEC	chr15	90466431	Missense_Mutation	rs765189988	A677V	0.05
UCEC	chr15	90453246	Missense_Mutation	novel	S481G	0.1
UCEC	chr15	90473939	Missense_Mutation	rs750370291	R826Q	0.1
UCEC	chr15	90474643	Missense_Mutation	NA	L912F	0.37
UCEC	chr15	90482048	Missense_Mutation	novel	A1140T	0.38
UCEC	chr15	90487036	Silent	NA	F1369F	0.5
UCEC	chr15	90500174	3'UTR	novel		0.33
UCEC	chr15	90482221	Missense_Mutation	NA	K1165N	0.23
UCEC	chr15	90500141	3'UTR	novel		0.51
UCEC	chr15	90500197	3'UTR	novel		0.54
UCEC	chr15	90500235	3'UTR	rs190948241		0.28
UCEC	chr15	90491453	Missense_Mutation	novel	E1457Q	0.33
UCEC	chr15	90491486	Nonsense_Mutation	NA	E1468*	0.13
UCEC	chr15	90466340	Missense_Mutation	rs780784277	R647C	0.31
UCEC	chr15	90452888	Missense_Mutation	rs545056140	A426T	0.52
UCEC	chr15	90482045	Missense_Mutation	NA	R1139W	0.38
UCEC	chr15	90477884	Missense_Mutation	novel	E1108D	0.1
UCEC	chr15	90477228	Missense_Mutation	NA	I1034M	0.36
UCEC	chr15	90456285	Silent	rs201387133	T582T	0.35
UCEC	chr15	90476693	Frame_Shift_Del	rs771739474	*N941Ifs8**	0.39
UCEC	chr15	90494763	Missense_Mutation	novel	S1560Y	0.47
UCEC	chr15	90500769	3'UTR	novel		0.5
UCEC	chr15	90426179	Silent	novel	G75G	0.27
UCEC	chr15	90482001	Missense_Mutation	rs775600587	H1124R	0.32
UCEC	chr15	90484329	Missense_Mutation	novel	G1300C	0.26
UCEC	chr15	90474493	Missense_Mutation	NA	E862Q	0.19
UCEC	chr15	90443454	Missense_Mutation	novel	Q297K	0.54
UCEC	chr15	90501047	3'UTR	novel		0.41
UCEC	chr15	90487502	Missense_Mutation	rs760969224	R1390C	0.33
UCEC	chr15	90476680	Frame_Shift_Ins	novel	*L937Tfs6**	0.32
UCEC	chr15	90452896	Silent	novel	L428L	0.6
UCEC	chr15	90454473	Missense_Mutation	novel	E511D	0.45
UCEC	chr15	90454435	Missense_Mutation	rs759044255	D499N	0.53
UCEC	chr15	90487036	Silent	NA	F1369F	0.4
UCEC	chr15	90473715	Frame_Shift_Del	novel	*S784Hfs16**	0.21
UCEC	chr15	90487039	Silent	rs528193427	D1370D	0.46
UCEC	chr15	90483478	Missense_Mutation	novel	L1225M	0.31
UCEC	chr15	90494763	Missense_Mutation	novel	S1560Y	0.57
UCEC	chr15	90502218	3'UTR	novel		0.45
UCEC	chr15	90486061	Missense_Mutation	rs758847813	P1318L	0.37
UCEC	chr15	90456285	Silent	rs201387133	T582T	0.35
UCEC	chr15	90483385	Nonsense_Mutation	novel	R1194*	0.4
UCEC	chr15	90500197	3'UTR	novel		0.36
UCEC	chr15	90453181	Missense_Mutation	rs546591604	S459L	0.42
UCEC	chr15	90454473	Missense_Mutation	novel	E511D	0.24
UCEC	chr15	90484253	Missense_Mutation	novel	E1274D	0.07
UCEC	chr15	90452891	Missense_Mutation	rs375355779	D427N	0.09
UCEC	chr15	90477119	Missense_Mutation	novel	S998F	0.53
UCEC	chr15	90486104	Silent	novel	G1332G	0.44
UCEC	chr15	90487503	Missense_Mutation	rs766747530	R1390H	0.24
UCEC	chr15	90448709	Silent	novel	L350L	0.21
UCEC	chr15	90477667	Missense_Mutation	rs201358762	S1036L	0.5
UCEC	chr15	90476688	Missense_Mutation	NA	L937R	0.27
UCEC	chr15	90448617	Missense_Mutation	novel	D320Y	0.2
UCEC	chr15	90502220	3'UTR	novel		0.11
UCEC	chr15	90473909	Missense_Mutation	NA	A816V	0.3
UCEC	chr15	90441620	Missense_Mutation	novel	A255V	0.27
UCEC	chr15	90443423	Silent	novel	V286V	0.17
UCEC	chr15	90466089	Missense_Mutation	novel	K622T	0.12
UCEC	chr15	90453284	In_Frame_Ins	novel	N493_C494insR	0.06
UCEC	chr15	90453285	Missense_Mutation	novel	C494S	0.06
UCEC	chr15	90494833	Missense_Mutation	novel	N1583K	0.41
UCEC	chr15	90501983	3'UTR	novel		0.27
UCEC	chr15	90452862	Missense_Mutation	novel	Q417R	0.29
UCEC	chr15	90474694	Splice_Site	novel	X928_splice	0.17
UCEC	chr15	90466006	Silent	NA	I594I	0.21
UCEC	chr15	90474694	Splice_Site	novel	X928_splice	0.14
UCEC	chr15	90497319	Missense_Mutation	NA	E1613D	0.23
UCEC	chr15	90449630	Silent	novel	Q383Q	0.41
UCEC	chr15	90494763	Missense_Mutation	novel	S1560Y	0.35
UCEC	chr15	90472958	Missense_Mutation	NA	R766Q	0.15
UCEC	chr15	90433753	Missense_Mutation	novel	R142Q	0.41
UCEC	chr15	90467468	Missense_Mutation	novel	W685L	0.16
UCEC	chr15	90474087	Silent	novel	Q843Q	0.21
UCEC	chr15	90482208	Missense_Mutation	novel	R1161H	0.13
UCEC	chr15	90492637	Silent	novel	T1518T	0.2
UCEC	chr15	90440591	Nonsense_Mutation	novel	E209*	0.39
UCEC	chr15	90492551	Missense_Mutation	novel	R1490W	0.38
UCEC	chr15	90448688	Silent	NA	S343S	0.33
UCEC	chr15	90466006	Silent	NA	I594I	0.13
UCEC	chr15	90481993	Silent	rs757661342	A1121A	0.34
UCEC	chr15	90500201	3'UTR	novel		0.46
UCEC	chr15	90473927	Missense_Mutation	rs199859960	R822Q	0.38
UCEC	chr15	90472882	Silent	novel	L741L	0.52
UCEC	chr15	90500275	3'UTR	novel		0.38
UCEC	chr15	90477667	Missense_Mutation	rs201358762	S1036L	0.43
UCS	chr15	90388394	Missense_Mutation	novel	G18D	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2203	0.0058042
ESCA	AMP	0.2717	0.10665
LGG	AMP	0.0253	0.19963
LIHC	DEL	0.1757	0.056724
PAAD	AMP	0.0815	0.20695
SKCM	AMP	0.2534	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
ACC	0.04	Kaplan-Meier Survival Analysis
SKCM	0.0095	Kaplan-Meier Survival Analysis
TGCT	0.043	Kaplan-Meier Survival Analysis
PAAD	0.00021	Kaplan-Meier Survival Analysis
BLCA	0.0074	Kaplan-Meier Survival Analysis
LAML	0.023	Kaplan-Meier Survival Analysis
KICH	0.032	Kaplan-Meier Survival Analysis
GBM	0.048	Kaplan-Meier Survival Analysis
UVM	0.00033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140575 (Gene tree)
Gene ID: 8826
Gene Symbol: IQGAP1
Alias: p195|KIAA0051|SAR1|HUMORFA01
Full Name: IQ motif containing GTPase activating protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 114,026 bases
Position: chr15:90,388,218-90,502,243
Accession: 6110
RBP type: non-canonical RBP
Summary: This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17137623	Targeting of calcium:calmodulin signals to the cytoskeleton by IQGAP1.	Cell Calcium	2007 Jun	Psatha MI	-
14699063	Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact.	Mol Biol Cell	2004 Mar	Noritake J	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000268182	IQGAP1-201	7233	-	ENSP00000268182	1657 (aa)	-	P46940
ENST00000560738	IQGAP1-214	3602	-	ENSP00000453181	1085 (aa)	-	H0YLE8
ENST00000633485	IQGAP1-218	5863	-	ENSP00000488618	1191 (aa)	-	A0A0J9YXZ5
ENST00000558491	IQGAP1-203	637	-	-	- (aa)	-	-
ENST00000558957	IQGAP1-204	2313	-	-	- (aa)	-	-
ENST00000560733	IQGAP1-213	565	-	-	- (aa)	-	-
ENST00000558003	IQGAP1-202	596	-	-	- (aa)	-	-
ENST00000559031	IQGAP1-205	583	-	-	- (aa)	-	-
ENST00000559674	IQGAP1-206	550	-	-	- (aa)	-	-
ENST00000560020	IQGAP1-209	440	-	-	- (aa)	-	-
ENST00000560218	IQGAP1-210	544	-	-	- (aa)	-	-
ENST00000561132	IQGAP1-216	601	-	-	- (aa)	-	-
ENST00000561086	IQGAP1-215	2871	-	-	- (aa)	-	-
ENST00000559809	IQGAP1-208	1201	-	ENSP00000484647	48 (aa)	-	A0A087X225
ENST00000560418	IQGAP1-212	559	-	ENSP00000452723	43 (aa)	-	H0YKA5
ENST00000559682	IQGAP1-207	376	-	-	- (aa)	-	-
ENST00000560373	IQGAP1-211	350	-	ENSP00000480393	107 (aa)	-	A0A087WWP1
ENST00000561461	IQGAP1-217	720	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000140575's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04520	Adherens junction	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05205	Proteoglycans in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140575	rs8042861	15	90434101	A	Multiple sclerosis	24076602		1.07	EFO_0003885
ENSG00000140575	rs3540	15	90502176	A	Lymphocyte counts	27863252	[0.03-0.045] unit increase	0.03771244	EFO_0004587
ENSG00000140575	rs145308728	15	90456925	G	Lymphocyte percentage of white cells	27863252	[0.032-0.05] unit increase	0.04057697	EFO_0007993
ENSG00000140575	rs2074585	15	90466252	A	White blood cell count (basophil)	27863252	[0.022-0.036] unit decrease	0.02881194	EFO_0005090
ENSG00000140575	rs2074585	15	90466252	A	Basophil percentage of white cells	27863252	[0.025-0.039] unit decrease	0.03212169	EFO_0007992
ENSG00000140575	rs2074585	15	90466252	A	Basophil percentage of granulocytes	27863252	[0.019-0.033] unit decrease	0.0259891	EFO_0007995
ENSG00000140575	rs2074585	15	90466252	A	Male-pattern baldness	28196072	NR unit decrease	0.041139	Orphanet_79364
ENSG00000140575	rs2074585	15	90466252	?	Balding type 1	30595370			EFO_0007825
ENSG00000140575	rs2074585	15	90466252	G	Male-pattern baldness	30573740	[0.034-0.046] unit increase	0.0395814	EFO_0007825
ENSG00000140575	rs2074585	15	90466252	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000140575	rs2074585	15	90466252	?	Eczema	30595370			HP_0000964

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140575's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140575	IQGAP1	98	100.000	ENSMUSG00000030536	Iqgap1	97	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	25554515.26242911.	IDA	Component
GO:0001817	regulation of cytokine production	-	IEA	Process
GO:0005095	GTPase inhibitor activity	8670801.	TAS	Function
GO:0005096	GTPase activator activity	8051149.	TAS	Function
GO:0005509	calcium ion binding	18567582.	TAS	Function
GO:0005515	protein binding	10793131.12745076.17563371.17620407.17853893.18567582.20875083.21349850.21724847.22662192.23982733.25074804.25554515.26242911.26496610.27173435.28007913.29033352.	IPI	Function
GO:0005516	calmodulin binding	18567582.	IDA	Function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	22493426.	IDA	Function
GO:0005634	nucleus	20883816.29033352.	IDA	Component
GO:0005737	cytoplasm	25554515.29033352.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0005884	actin filament	8670801.	TAS	Component
GO:0005886	plasma membrane	29033352.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007165	signal transduction	8051149.	TAS	Process
GO:0007173	epidermal growth factor receptor signaling pathway	17563371.	IMP	Process
GO:0007346	regulation of mitotic cell cycle	20883816.	IMP	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IEA	Process
GO:0015629	actin cytoskeleton	-	ISS	Component
GO:0015630	microtubule cytoskeleton	-	ISS	Component
GO:0016032	viral process	-	IEA	Process
GO:0016328	lateral plasma membrane	-	IEA	Component
GO:0016477	cell migration	26242911.	IMP	Process
GO:0019901	protein kinase binding	17563371.	IPI	Function
GO:0019903	protein phosphatase binding	16380380.	IPI	Function
GO:0019904	protein domain specific binding	25554515.	IPI	Function
GO:0030424	axon	-	ISS	Component
GO:0030426	growth cone	-	ISS	Component
GO:0030496	midbody	15166316.	IDA	Component
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	22493426.	IDA	Component
GO:0031267	small GTPase binding	26242911.	IPI	Function
GO:0034260	negative regulation of GTPase activity	-	IEA	Process
GO:0035305	negative regulation of dephosphorylation	-	IEA	Process
GO:0036057	slit diaphragm	-	ISS	Component
GO:0036120	cellular response to platelet-derived growth factor stimulus	-	IEA	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	15121898.	IDA	Component
GO:0043005	neuron projection	-	ISS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043406	positive regulation of MAP kinase activity	-	IEA	Process
GO:0043539	protein serine/threonine kinase activator activity	17563371.	IDA	Function
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0044548	S100 protein binding	25554515.	IPI	Function
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045121	membrane raft	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045860	positive regulation of protein kinase activity	17563371.	IMP	Process
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	IEA	Process
GO:0048365	Rac GTPase binding	-	IEA	Function
GO:0051019	mitogen-activated protein kinase binding	-	IEA	Function
GO:0051894	positive regulation of focal adhesion assembly	-	IEA	Process
GO:0060090	molecular adaptor activity	26242911.	IDA	Function
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0071277	cellular response to calcium ion	18567582.	IDA	Process
GO:0071364	cellular response to epidermal growth factor stimulus	17563371.26242911.	IMP	Process
GO:0072015	glomerular visceral epithelial cell development	-	ISS	Process
GO:1900006	positive regulation of dendrite development	-	IEA	Process
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	-	IEA	Process
GO:1903829	positive regulation of cellular protein localization	-	IEA	Process
GO:1904754	positive regulation of vascular associated smooth muscle cell migration	-	IEA	Process
GO:1990138	neuron projection extension	15695813.	IMP	Process
GO:1990776	response to angiotensin	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.