EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26078295Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.Mol Cancer Res2015 SepHensel Jdoi: 10.1158/1541-7786.MCR-15-0130
26398880miR-506 regulates breast cancer cell metastasis by targeting IQGAP1.Int J Oncol2015 NovSun Gdoi: 10.3892/ijo.2015.3161
23454766IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.J Clin Invest2013 MarLiu Cdoi: 10.1172/JCI63836
24800852Targeted knockdown of IQGAP1 inhibits the progression of esophageal squamous cell carcinoma in vitro and in vivo.PLoS One2014 May 6Wang XXdoi: 10.1371/journal.pone.0096501
20959410IQGAP1 plays an important role in the invasiveness of thyroid cancer.Clin Cancer Res2010 Dec 15Liu Zdoi: 10.1158/1078-0432.CCR-10-1627
25675045IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.Int J Gynecol Cancer2015 MayHuang Ldoi: 10.1097/IGC.0000000000000394.
27100492Potential involvement of IQGAP1 in proliferation and metastasis of human pancreatic cancer.Front Biosci (Landmark Ed)2016 Jun 1Jin Y-
19856315Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion.Int J Cancer2010 Jun 1Hayashi Hdoi: 10.1002/ijc.24987.
19036171Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro.J Exp Clin Cancer Res2008 Nov 27Dong PXdoi: 10.1186/1756-9966-27-77.
22483753IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer.Biochem Biophys Res Commun2012 Apr 27Yin Ndoi: 10.1016/j.bbrc.2012.03.112
24103286Overexpression of IQGAP1 in human pancreatic cancer.Hepatobiliary Pancreat Dis Int2013 OctWang XX-
25436461Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer.PLoS One2014 Dec 1Zhao Hdoi: 10.1371/journal.pone.0113713
26046126IQGAP1 modulates the proliferation and invasion of thyroid cancer cells in response to estrogen.Int J Mol Med2015 AugMeng Ddoi: 10.3892/ijmm.2015.2232
27470543MALAT1 promotes the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1.Biomed Pharmacother2016 OctHuang JKdoi: 10.1016/j.biopha.2016.05.039
21621326Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway.Cancer Lett2011 Sep 28Tang MCdoi: 10.1016/j.canlet.2011.05.001
21318219Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.Int J Oncol2011 AprZheng Hdoi: 10.3892/ijo.2011.940
23145020RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1.PLoS One2012Wu Ydoi: 10.1371/journal.pone.0048917
28618949IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.Tumour Biol2017 JunZhao HYdoi: 10.1177/1010428317705769.
28739799LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.J Biol Chem2017 Sep 8Carmon KSdoi: 10.1074/jbc.M117.786798
26934121Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression.Oncotarget2016 Apr 12Dong Pdoi: 10.18632/oncotarget.7754.
29779034Ras GTPase-Activating-Like Protein IQGAP1 (IQGAP1) Promotes Breast Cancer Proliferation and Invasion and Correlates with Poor Clinical Outcomes.Med Sci Monit2018 May 20Zeng Fdoi: 10.12659/MSM.909916.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1590467590In_Frame_Insnovel0.05
BLCAchr1590473751Missense_MutationnovelQ796E0.22
BLCAchr1590477153SilentnovelL1009L0.33
BLCAchr1590482239SilentNAL1171L0.36
BLCAchr1590492620Missense_MutationnovelL1513V0.08
BLCAchr1590454446Missense_MutationnovelM502I0.28
BLCAchr1590433742Silentrs767016252D138D0.25
BLCAchr1590477114SilentnovelN996N0.16
BLCAchr1590474588SilentnovelR893R0.21
BLCAchr1590474589Nonsense_MutationnovelE894*0.22
BLCAchr1590477813Missense_MutationnovelL1085F0.57
BLCAchr1590476771Frame_Shift_DelnovelK965Efs*620.36
BLCAchr1590477873Nonsense_MutationnovelQ1105*0.41
BLCAchr1590473926Nonsense_MutationnovelR822*0.05
BLCAchr1590426241Missense_Mutationrs770042259Y96C0.07
BLCAchr1590429595Missense_MutationNAG107S0.33
BLCAchr1590452896SilentNAL428L0.33
BLCAchr1590482227Silentrs761144008L1167L0.28
BRCAchr1590426235Frame_Shift_DelNAK94Tfs*220.17
BRCAchr1590477787Missense_MutationnovelV1076G0.08
BRCAchr1590476692Frame_Shift_InsNAN941Kfs*20.39
BRCAchr1590476722Missense_MutationNAM948I0.6
BRCAchr15905001443'UTRnovel0.11
BRCAchr1590440512SilentnovelI182I0.09
BRCAchr1590466330SilentNAL643L0.32
BRCAchr1590472905SilentNAL748L0.25
BRCAchr1590476722Missense_MutationNAM948I0.28
BRCAchr1590477875Missense_MutationNAQ1105H0.27
BRCAchr1590483562Missense_MutationNAE1253K0.24
BRCAchr1590487073Nonsense_MutationnovelR1382*0.07
CESCchr15905001143'UTRrs1449217100.1
CESCchr1590453181Missense_Mutationrs546591604S459L0.19
CESCchr1590491527Silentrs199804766L1481L0.21
CESCchr1590500100Missense_MutationNAG1656R0.22
CESCchr1590440528Missense_MutationNAE188K0.37
CESCchr15905001813'UTRnovel0.35
CESCchr1590487577Frame_Shift_InsnovelE1415Vfs*180.25
CESCchr1590487579Frame_Shift_DelnovelQ1416Kfs*220.25
CESCchr1590429636Missense_MutationNAL120F0.43
CESCchr1590433786Frame_Shift_InsnovelH153Qfs*240.1
CESCchr1590467544Frame_Shift_DelnovelP711Qfs*220.17
CESCchr1590449623Missense_MutationNAA381V0.17
CESCchr1590466046Missense_MutationNAG608R0.21
CESCchr1590453242SilentNAL479L0.48
CESCchr1590483529Missense_MutationNAL1242V0.25
CESCchr1590443391Splice_Regionnovel0.34
CESCchr1590474624Missense_MutationNAQ905H0.11
COADchr1590491541Missense_MutationnovelA1486V0.11
COADchr1590452854Silentrs770596390P414P0.35
COADchr1590483443Missense_MutationNAA1213V0.21
COADchr1590454543Missense_MutationnovelE535K0.16
COADchr1590472905SilentNAL748L0.25
COADchr1590456213SilentNAL558L0.29
COADchr1590454480Nonsense_MutationnovelE514*0.32
COADchr1590467490SilentnovelG692G0.46
COADchr15905001343'UTRnovel0.39
COADchr1590476693Frame_Shift_Delrs771739474N941Ifs*80.43
COADchr1590483436Missense_Mutationrs535117997L1211M0.36
COADchr1590473714Splice_SitenovelX784_splice0.42
COADchr1590390871Missense_MutationNAK51N0.16
COADchr1590486051Missense_MutationnovelA1315T0.2
COADchr1590500012Silentrs778382730Q1626Q0.42
COADchr1590477671SilentNAK1037K0.31
COADchr1590492665Frame_Shift_DelNAS1529Afs*100.15
COADchr1590484221Missense_Mutationrs763205486R1264W0.43
COADchr1590441592Missense_Mutationrs753859958M246V0.17
COADchr1590440612Missense_Mutationrs772573837A216T0.32
COADchr1590494825Missense_MutationNAQ1581K0.2
COADchr1590426179Frame_Shift_InsnovelV76Kfs*240.08
COADchr1590448688In_Frame_InsnovelS343_D344insL0.06
DLBCchr1590433754SilentnovelR142R0.27
ESCAchr1590491498Missense_Mutationrs751120932V1472M0.13
ESCAchr1590388355Missense_MutationnovelD5G0.28
ESCAchr15905019693'UTRnovel0.38
GBMchr1590426124Missense_MutationnovelC57F0.17
GBMchr1590454473Missense_MutationnovelE511D0.35
GBMchr1590473757Missense_Mutationrs762319697R798W0.36
GBMchr1590441572Missense_MutationnovelA239G0.06
GBMchr1590429650Missense_Mutationrs764973369E125A0.29
GBMchr1590483381Nonsense_MutationnovelY1192*0.04
HNSCchr1590491398Missense_Mutationrs752418699M1438I0.11
HNSCchr1590486075Missense_MutationnovelP1323A0.3
HNSCchr1590486128SilentnovelL1340L0.23
HNSCchr1590441545Missense_Mutationrs372323221R230H0.28
HNSCchr1590390804Missense_MutationnovelE29V0.09
HNSCchr1590390827Frame_Shift_InsnovelN38Efs*50.23
HNSCchr1590390829Missense_MutationnovelQ37H0.23
HNSCchr1590477730Missense_MutationnovelS1057T0.09
HNSCchr1590487036SilentNAF1369F0.14
HNSCchr1590439344Missense_MutationnovelF160L0.08
HNSCchr1590487040Missense_Mutationrs181919733V1371M0.09
HNSCchr1590497282Nonsense_MutationnovelF1601_E1602delins*0.27
HNSCchr1590492614Missense_MutationnovelA1511S0.1
HNSCchr15905001193'UTRnovel0.63
HNSCchr1590483555SilentnovelI1250I0.08
KICHchr1590487033Frame_Shift_DelnovelF1369Efs*140.4
KIRCchr1590492587Frame_Shift_DelnovelE1502Nfs*20.29
KIRCchr1590477777Missense_MutationNAA1073S0.24
KIRCchr1590477778Missense_MutationNAA1073D0.23
KIRCchr1590477681Missense_MutationNAI1041L0.17
KIRCchr1590482212SilentnovelF1162F0.19
KIRCchr1590491492Nonsense_MutationnovelG1470Efs*40.09
KIRCchr1590491494SilentnovelG1470G0.05
KIRPchr1590474561SilentnovelQ884Q0.52
KIRPchr1590466320Missense_MutationNAG640V0.26
LAMLchr1590454530Frame_Shift_DelnovelV531Wfs*100.03
LAMLchr1590441513SilentnovelA219A0.14
LGGchr1590472958Missense_MutationNAR766Q0.32
LGGchr1590390867Missense_Mutationrs745638782A50V0.38
LGGchr1590429590Missense_Mutationrs768861482A105V0.34
LGGchr1590452817Missense_MutationnovelG402D0.34
LGGchr1590482259Missense_MutationnovelA1178V0.26
LGGchr1590487074Missense_Mutationrs776564409R1382Q0.29
LGGchr15905001413'UTRnovel0.33
LGGchr1590487499Missense_Mutationrs200349977K1389E0.22
LGGchr1590491357Nonsense_MutationNAQ1425*0.14
LIHCchr1590443441Silentrs375134287T292T0.22
LIHCchr1590500044Missense_MutationNAD1637A0.07
LIHCchr1590433780Missense_MutationnovelC151S0.31
LIHCchr1590474502Missense_MutationNAP865S0.29
LIHCchr1590477709Missense_MutationNAT1050M0.23
LIHCchr1590494772Missense_MutationnovelY1563C0.38
LUADchr1590452894Missense_MutationnovelL428F0.09
LUADchr1590453162Missense_MutationNAA453S0.08
LUADchr1590482089SilentnovelV1153V0.09
LUADchr1590492561Missense_MutationnovelR1493L0.34
LUADchr1590494780Missense_MutationnovelA1566T0.18
LUADchr1590449629Missense_MutationnovelQ383R0.15
LUADchr1590441514Missense_MutationnovelA220S0.15
LUADchr1590492586Silentrs750054244A1501A0.13
LUADchr1590388371SilentNAL10L0.21
LUADchr1590477739Missense_MutationNAR1060L0.05
LUADchr1590443473Splice_SitenovelX303_splice0.12
LUSCchr1590439391Missense_MutationnovelD176V0.29
LUSCchr1590491399Missense_MutationnovelK1439Q0.83
LUSCchr1590453142Missense_MutationnovelT446I0.23
LUSCchr1590487478Intronnovel0.37
LUSCchr1590484337SilentNAI1302I0.14
LUSCchr1590467544Frame_Shift_DelnovelP711Qfs*220.66
LUSCchr1590456244Nonsense_MutationNAE569*0.15
LUSCchr1590390825Missense_Mutationrs570821440R36H0.17
LUSCchr1590482085Missense_MutationNAS1152F0.26
LUSCchr1590477684Missense_MutationNAQ1042E0.09
LUSCchr1590483559Missense_MutationnovelN1252D0.24
LUSCchr1590466056Missense_MutationnovelW611L0.24
LUSCchr1590466057Missense_MutationnovelW611C0.24
LUSCchr1590486992Missense_MutationnovelA1355S0.56
LUSCchr1590494767SilentNAL1561L0.33
LUSCchr1590477137Missense_MutationnovelS1004C0.34
LUSCchr1590486987Missense_MutationnovelK1353M0.12
LUSCchr1590483391Missense_MutationnovelM1196V0.23
LUSCchr1590452900Missense_MutationNAQ430E0.09
MESOchr15905002543'UTRnovel0.29
OVchr1590476739Missense_MutationNAQ954R0.88
OVchr1590486040Missense_MutationNAD1311G0.23
OVchr15905002163'UTRnovel0.07
PAADchr1590474110Missense_MutationnovelA851V0.18
PAADchr1590474112Missense_MutationnovelR852W0.11
PAADchr15903883345'UTRrs7589342180.12
PRADchr1590497338Nonsense_Mutationrs755073388Q1620*0.31
PRADchr1590484248Missense_MutationNAP1273A0.22
PRADchr1590466369SilentnovelV656V0.55
PRADchr1590481993Silentrs757661342A1121A0.32
READchr1590483555SilentNAI1250I0.22
READchr1590476692Frame_Shift_InsNAN941Kfs*20.26
READchr1590433768Missense_MutationnovelR147I0.45
READchr1590452780Missense_MutationNAA390T0.37
READchr1590492702Missense_MutationnovelS1540I0.47
READchr1590449560Missense_MutationNAS360N0.13
SARCchr1590390866Missense_MutationnovelA50S0.21
SARCchr1590448626Missense_MutationnovelA323S0.09
SARCchr1590484329Missense_MutationnovelG1300S0.53
SARCchr1590484330Missense_MutationnovelG1300D0.53
SARCchr1590494765Missense_MutationnovelL1561M0.08
SARCchr1590491443Missense_MutationnovelQ1453H0.15
SKCMchr1590456252SilentNAV571V0.39
SKCMchr1590473904Silentrs754652245S814S0.12
SKCMchr1590439357Missense_MutationnovelA165T0.65
SKCMchr1590473904Silentrs754652245S814S0.31
SKCMchr1590482212SilentnovelF1162F0.3
SKCMchr15905001143'UTRrs1449217100.18
SKCMchr1590482075Missense_MutationnovelI1149V0.3
SKCMchr1590484247SilentNAV1272V0.41
SKCMchr1590483527Missense_MutationnovelF1241Y0.41
SKCMchr1590491352Missense_MutationNAA1423V0.17
SKCMchr1590466063SilentNAS613S0.25
SKCMchr1590441583Missense_MutationNAP243S0.12
SKCMchr1590487487Splice_Regionnovel0.27
SKCMchr1590474085Nonsense_MutationNAQ843*0.18
SKCMchr1590441515Missense_MutationNAA220V0.13
SKCMchr1590484247SilentNAV1272V0.31
SKCMchr15905001623'UTRnovel0.56
SKCMchr1590473904Silentrs754652245S814S0.64
SKCMchr1590441554Missense_MutationNAP233L0.51
SKCMchr1590476757Missense_MutationnovelA960V0.4
SKCMchr1590473903Missense_MutationnovelS814F0.18
SKCMchr1590474097Missense_MutationNAR847W0.33
SKCMchr1590441518Missense_MutationNAV221A0.4
SKCMchr1590482235Missense_Mutationrs139658864S1170L0.47
STADchr1590492613SilentnovelY1510Y0.51
STADchr1590441649Missense_MutationNAA265T0.3
STADchr1590474098Missense_MutationNAR847Q0.23
STADchr1590494724Missense_MutationNAK1547R0.12
STADchr1590491391Missense_MutationNAD1436A0.31
STADchr1590494732Missense_MutationNAE1550K0.13
STADchr1590476770Missense_MutationNAE964D0.4
STADchr1590433762Missense_MutationnovelM145T0.29
STADchr1590484340SilentnovelI1303I0.32
STADchr1590466423Missense_MutationNAK674N0.11
STADchr1590452823Missense_MutationnovelA404V0.45
STADchr1590453251SilentNAS482S0.1
STADchr1590473956Missense_MutationNAF832V0.06
STADchr1590466302Missense_MutationnovelV634A0.37
STADchr1590476692Frame_Shift_InsNAN941Kfs*20.27
STADchr1590476693Frame_Shift_Delrs771739474N941Ifs*80.28
STADchr1590492609Missense_MutationNAT1509I0.26
STADchr1590454523Missense_MutationNAV528G0.38
STADchr1590429657SilentNAG127G0.2
STADchr1590441557Missense_MutationNAA234V0.18
STADchr1590484221Missense_Mutationrs763205486R1264W0.23
UCECchr1590477886Missense_MutationnovelA1109G0.32
UCECchr1590483381Frame_Shift_DelnovelY1193Ifs*40.43
UCECchr1590487036SilentNAF1369F0.33
UCECchr1590466431Missense_Mutationrs765189988A677V0.05
UCECchr1590453246Missense_MutationnovelS481G0.1
UCECchr1590473939Missense_Mutationrs750370291R826Q0.1
UCECchr1590474643Missense_MutationNAL912F0.37
UCECchr1590482048Missense_MutationnovelA1140T0.38
UCECchr1590487036SilentNAF1369F0.5
UCECchr15905001743'UTRnovel0.33
UCECchr1590482221Missense_MutationNAK1165N0.23
UCECchr15905001413'UTRnovel0.51
UCECchr15905001973'UTRnovel0.54
UCECchr15905002353'UTRrs1909482410.28
UCECchr1590491453Missense_MutationnovelE1457Q0.33
UCECchr1590491486Nonsense_MutationNAE1468*0.13
UCECchr1590466340Missense_Mutationrs780784277R647C0.31
UCECchr1590452888Missense_Mutationrs545056140A426T0.52
UCECchr1590482045Missense_MutationNAR1139W0.38
UCECchr1590477884Missense_MutationnovelE1108D0.1
UCECchr1590477228Missense_MutationNAI1034M0.36
UCECchr1590456285Silentrs201387133T582T0.35
UCECchr1590476693Frame_Shift_Delrs771739474N941Ifs*80.39
UCECchr1590494763Missense_MutationnovelS1560Y0.47
UCECchr15905007693'UTRnovel0.5
UCECchr1590426179SilentnovelG75G0.27
UCECchr1590482001Missense_Mutationrs775600587H1124R0.32
UCECchr1590484329Missense_MutationnovelG1300C0.26
UCECchr1590474493Missense_MutationNAE862Q0.19
UCECchr1590443454Missense_MutationnovelQ297K0.54
UCECchr15905010473'UTRnovel0.41
UCECchr1590487502Missense_Mutationrs760969224R1390C0.33
UCECchr1590476680Frame_Shift_InsnovelL937Tfs*60.32
UCECchr1590452896SilentnovelL428L0.6
UCECchr1590454473Missense_MutationnovelE511D0.45
UCECchr1590454435Missense_Mutationrs759044255D499N0.53
UCECchr1590487036SilentNAF1369F0.4
UCECchr1590473715Frame_Shift_DelnovelS784Hfs*160.21
UCECchr1590487039Silentrs528193427D1370D0.46
UCECchr1590483478Missense_MutationnovelL1225M0.31
UCECchr1590494763Missense_MutationnovelS1560Y0.57
UCECchr15905022183'UTRnovel0.45
UCECchr1590486061Missense_Mutationrs758847813P1318L0.37
UCECchr1590456285Silentrs201387133T582T0.35
UCECchr1590483385Nonsense_MutationnovelR1194*0.4
UCECchr15905001973'UTRnovel0.36
UCECchr1590453181Missense_Mutationrs546591604S459L0.42
UCECchr1590454473Missense_MutationnovelE511D0.24
UCECchr1590484253Missense_MutationnovelE1274D0.07
UCECchr1590452891Missense_Mutationrs375355779D427N0.09
UCECchr1590477119Missense_MutationnovelS998F0.53
UCECchr1590486104SilentnovelG1332G0.44
UCECchr1590487503Missense_Mutationrs766747530R1390H0.24
UCECchr1590448709SilentnovelL350L0.21
UCECchr1590477667Missense_Mutationrs201358762S1036L0.5
UCECchr1590476688Missense_MutationNAL937R0.27
UCECchr1590448617Missense_MutationnovelD320Y0.2
UCECchr15905022203'UTRnovel0.11
UCECchr1590473909Missense_MutationNAA816V0.3
UCECchr1590441620Missense_MutationnovelA255V0.27
UCECchr1590443423SilentnovelV286V0.17
UCECchr1590466089Missense_MutationnovelK622T0.12
UCECchr1590453284In_Frame_InsnovelN493_C494insR0.06
UCECchr1590453285Missense_MutationnovelC494S0.06
UCECchr1590494833Missense_MutationnovelN1583K0.41
UCECchr15905019833'UTRnovel0.27
UCECchr1590452862Missense_MutationnovelQ417R0.29
UCECchr1590474694Splice_SitenovelX928_splice0.17
UCECchr1590466006SilentNAI594I0.21
UCECchr1590474694Splice_SitenovelX928_splice0.14
UCECchr1590497319Missense_MutationNAE1613D0.23
UCECchr1590449630SilentnovelQ383Q0.41
UCECchr1590494763Missense_MutationnovelS1560Y0.35
UCECchr1590472958Missense_MutationNAR766Q0.15
UCECchr1590433753Missense_MutationnovelR142Q0.41
UCECchr1590467468Missense_MutationnovelW685L0.16
UCECchr1590474087SilentnovelQ843Q0.21
UCECchr1590482208Missense_MutationnovelR1161H0.13
UCECchr1590492637SilentnovelT1518T0.2
UCECchr1590440591Nonsense_MutationnovelE209*0.39
UCECchr1590492551Missense_MutationnovelR1490W0.38
UCECchr1590448688SilentNAS343S0.33
UCECchr1590466006SilentNAI594I0.13
UCECchr1590481993Silentrs757661342A1121A0.34
UCECchr15905002013'UTRnovel0.46
UCECchr1590473927Missense_Mutationrs199859960R822Q0.38
UCECchr1590472882SilentnovelL741L0.52
UCECchr15905002753'UTRnovel0.38
UCECchr1590477667Missense_Mutationrs201358762S1036L0.43
UCSchr1590388394Missense_MutationnovelG18D0.29

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.22030.0058042
ESCAAMP0.27170.10665
LGGAMP0.02530.19963
LIHCDEL0.17570.056724
PAADAMP0.08150.20695
SKCMAMP0.25349.6912e-06

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

ACC0.04

Kaplan-Meier Survival Analysis

SKCM0.0095

Kaplan-Meier Survival Analysis

TGCT0.043

Kaplan-Meier Survival Analysis

PAAD0.00021

Kaplan-Meier Survival Analysis

BLCA0.0074

Kaplan-Meier Survival Analysis

LAML0.023

Kaplan-Meier Survival Analysis

KICH0.032

Kaplan-Meier Survival Analysis

GBM0.048

Kaplan-Meier Survival Analysis

UVM0.00033

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000140575 (Gene tree)
Gene ID
8826
Gene Symbol
IQGAP1
Alias
p195|KIAA0051|SAR1|HUMORFA01
Full Name
IQ motif containing GTPase activating protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
114,026 bases
Position
chr15:90,388,218-90,502,243
Accession
6110
RBP type
non-canonical RBP
Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17137623Targeting of calcium:calmodulin signals to the cytoskeleton by IQGAP1.Cell Calcium2007 JunPsatha MI-
14699063Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact.Mol Biol Cell2004 MarNoritake J-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000268182IQGAP1-2017233-ENSP000002681821657 (aa)-P46940
ENST00000560738IQGAP1-2143602-ENSP000004531811085 (aa)-H0YLE8
ENST00000633485IQGAP1-2185863-ENSP000004886181191 (aa)-A0A0J9YXZ5
ENST00000558491IQGAP1-203637--- (aa)--
ENST00000558957IQGAP1-2042313--- (aa)--
ENST00000560733IQGAP1-213565--- (aa)--
ENST00000558003IQGAP1-202596--- (aa)--
ENST00000559031IQGAP1-205583--- (aa)--
ENST00000559674IQGAP1-206550--- (aa)--
ENST00000560020IQGAP1-209440--- (aa)--
ENST00000560218IQGAP1-210544--- (aa)--
ENST00000561132IQGAP1-216601--- (aa)--
ENST00000561086IQGAP1-2152871--- (aa)--
ENST00000559809IQGAP1-2081201-ENSP0000048464748 (aa)-A0A087X225
ENST00000560418IQGAP1-212559-ENSP0000045272343 (aa)-H0YKA5
ENST00000559682IQGAP1-207376--- (aa)--
ENST00000560373IQGAP1-211350-ENSP00000480393107 (aa)-A0A087WWP1
ENST00000561461IQGAP1-217720--- (aa)--
Gene Model
Click here to download ENSG00000140575's gene model file
Pathways
Pathway IDPathway NameSource
hsa04520Adherens junctionKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05205Proteoglycans in cancerKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000140575rs80428611590434101AMultiple sclerosis240766021.07EFO_0003885
ENSG00000140575rs35401590502176ALymphocyte counts27863252[0.03-0.045] unit increase0.03771244EFO_0004587
ENSG00000140575rs1453087281590456925GLymphocyte percentage of white cells27863252[0.032-0.05] unit increase0.04057697EFO_0007993
ENSG00000140575rs20745851590466252AWhite blood cell count (basophil)27863252[0.022-0.036] unit decrease0.02881194EFO_0005090
ENSG00000140575rs20745851590466252ABasophil percentage of white cells27863252[0.025-0.039] unit decrease0.03212169EFO_0007992
ENSG00000140575rs20745851590466252ABasophil percentage of granulocytes27863252[0.019-0.033] unit decrease0.0259891EFO_0007995
ENSG00000140575rs20745851590466252AMale-pattern baldness28196072NR unit decrease0.041139Orphanet_79364
ENSG00000140575rs20745851590466252?Balding type 130595370EFO_0007825
ENSG00000140575rs20745851590466252GMale-pattern baldness30573740[0.034-0.046] unit increase0.0395814EFO_0007825
ENSG00000140575rs20745851590466252?Red cell distribution width30595370EFO_0005192
ENSG00000140575rs20745851590466252?Eczema30595370HP_0000964
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140575's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000140575IQGAP198100.000ENSMUSG00000030536Iqgap197100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001726ruffle25554515.26242911.IDAComponent
GO:0001817regulation of cytokine production-IEAProcess
GO:0005095GTPase inhibitor activity8670801.TASFunction
GO:0005096GTPase activator activity8051149.TASFunction
GO:0005509calcium ion binding18567582.TASFunction
GO:0005515protein binding10793131.12745076.17563371.17620407.17853893.18567582.20875083.21349850.21724847.22662192.23982733.25074804.25554515.26242911.26496610.27173435.28007913.29033352.IPIFunction
GO:0005516calmodulin binding18567582.IDAFunction
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding22493426.IDAFunction
GO:0005634nucleus20883816.29033352.IDAComponent
GO:0005737cytoplasm25554515.29033352.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule21525035.IDAComponent
GO:0005884actin filament8670801.TASComponent
GO:0005886plasma membrane29033352.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0007165signal transduction8051149.TASProcess
GO:0007173epidermal growth factor receptor signaling pathway17563371.IMPProcess
GO:0007346regulation of mitotic cell cycle20883816.IMPProcess
GO:0008543fibroblast growth factor receptor signaling pathway-IEAProcess
GO:0015629actin cytoskeleton-ISSComponent
GO:0015630microtubule cytoskeleton-ISSComponent
GO:0016032viral process-IEAProcess
GO:0016328lateral plasma membrane-IEAComponent
GO:0016477cell migration26242911.IMPProcess
GO:0019901protein kinase binding17563371.IPIFunction
GO:0019903protein phosphatase binding16380380.IPIFunction
GO:0019904protein domain specific binding25554515.IPIFunction
GO:0030424axon-ISSComponent
GO:0030426growth cone-ISSComponent
GO:0030496midbody15166316.IDAComponent
GO:0030667secretory granule membrane-TASComponent
GO:0031234extrinsic component of cytoplasmic side of plasma membrane22493426.IDAComponent
GO:0031267small GTPase binding26242911.IPIFunction
GO:0034260negative regulation of GTPase activity-IEAProcess
GO:0035305negative regulation of dephosphorylation-IEAProcess
GO:0036057slit diaphragm-ISSComponent
GO:0036120cellular response to platelet-derived growth factor stimulus-IEAProcess
GO:0036464cytoplasmic ribonucleoprotein granule15121898.IDAComponent
GO:0043005neuron projection-ISSComponent
GO:0043312neutrophil degranulation-TASProcess
GO:0043406positive regulation of MAP kinase activity-IEAProcess
GO:0043539protein serine/threonine kinase activator activity17563371.IDAFunction
GO:0043547positive regulation of GTPase activity-IEAProcess
GO:0044548S100 protein binding25554515.IPIFunction
GO:0044877protein-containing complex binding-IEAFunction
GO:0045121membrane raft-IEAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0045860positive regulation of protein kinase activity17563371.IMPProcess
GO:0048008platelet-derived growth factor receptor signaling pathway-IEAProcess
GO:0048365Rac GTPase binding-IEAFunction
GO:0051019mitogen-activated protein kinase binding-IEAFunction
GO:0051894positive regulation of focal adhesion assembly-IEAProcess
GO:0060090molecular adaptor activity26242911.IDAFunction
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:0071277cellular response to calcium ion18567582.IDAProcess
GO:0071364cellular response to epidermal growth factor stimulus17563371.26242911.IMPProcess
GO:0072015glomerular visceral epithelial cell development-ISSProcess
GO:1900006positive regulation of dendrite development-IEAProcess
GO:1900086positive regulation of peptidyl-tyrosine autophosphorylation-IEAProcess
GO:1903829positive regulation of cellular protein localization-IEAProcess
GO:1904754positive regulation of vascular associated smooth muscle cell migration-IEAProcess
GO:1990138neuron projection extension15695813.IMPProcess
GO:1990776response to angiotensin-IEAProcess
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