EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19737859	Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.	Carcinogenesis	2009 Nov	Garc??a MJ	doi: 10.1093/carcin/bgp218

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	89247702	Missense_Mutation	novel	E19K	0.39
ACC	chr15	89281841	Splice_Region	novel		0.29
BLCA	chr15	89264017	Silent	novel	L220L	0.12
BLCA	chr15	89315378	Missense_Mutation	rs773521811	E1305K	0.43
BLCA	chr15	89305186	Missense_Mutation	NA	I1044L	0.33
BLCA	chr15	89301432	Missense_Mutation	novel	S999F	0.25
BLCA	chr15	89247669	Missense_Mutation	rs772954096	L8V	0.12
BLCA	chr15	89292732	Missense_Mutation	NA	K679N	0.32
BLCA	chr15	89292954	Missense_Mutation	NA	D728H	0.25
BLCA	chr15	89276765	Missense_Mutation	novel	L389F	0.06
BLCA	chr15	89291640	Missense_Mutation	novel	D640H	0.1
BLCA	chr15	89307511	Frame_Shift_Del	novel	*N1193Ifs6**	0.17
BLCA	chr15	89293886	Missense_Mutation	novel	S782F	0.09
BLCA	chr15	89291664	Missense_Mutation	NA	E648Q	0.2
BLCA	chr15	89258760	Silent	novel	L47L	0.24
BLCA	chr15	89316847	3'UTR	novel		0.69
BLCA	chr15	89261588	Missense_Mutation	novel	H98Y	0.09
BLCA	chr15	89264017	Silent	novel	L220L	0.17
BLCA	chr15	89291698	Missense_Mutation	NA	S659C	0.34
BLCA	chr15	89307662	Missense_Mutation	NA	S1214C	0.24
BLCA	chr15	89261698	Silent	novel	L134L	0.31
BLCA	chr15	89314694	Missense_Mutation	novel	S1268C	0.32
BRCA	chr15	89294987	Silent	NA	V843V	0.31
BRCA	chr15	89306064	Missense_Mutation	novel	M1136R	0.26
BRCA	chr15	89281868	Intron	novel		0.52
BRCA	chr15	89292763	Missense_Mutation	NA	E690K	0.23
BRCA	chr15	89316693	3'UTR	novel		0.32
BRCA	chr15	89263986	Missense_Mutation	NA	I210T	0.32
BRCA	chr15	89263965	Missense_Mutation	novel	S203F	0.42
BRCA	chr15	89264519	Splice_Region	novel		0.35
BRCA	chr15	89292781	Missense_Mutation	NA	E696K	0.15
BRCA	chr15	89263972	Missense_Mutation	novel	M205I	0.09
BRCA	chr15	89274274	Missense_Mutation	NA	S361L	0.21
BRCA	chr15	89285127	Missense_Mutation	NA	S577F	0.14
BRCA	chr15	89307629	Missense_Mutation	NA	S1203C	0.16
BRCA	chr15	89299799	Splice_Site	NA	X879_splice	0.32
BRCA	chr15	89306053	Missense_Mutation	novel	K1132N	0.13
BRCA	chr15	89306167	Silent	NA	Y1170Y	0.14
CESC	chr15	89281791	Missense_Mutation	NA	M513I	0.13
CESC	chr15	89285093	Splice_Region	novel		0.17
CESC	chr15	89316708	3'UTR	rs200390876		0.14
CESC	chr15	89285099	Missense_Mutation	novel	H568N	0.26
CESC	chr15	89247692	Silent	novel	D15D	0.35
CESC	chr15	89294959	Missense_Mutation	novel	S834F	0.18
CESC	chr15	89264588	Missense_Mutation	NA	E246Q	0.2
CESC	chr15	89291643	Silent	novel	L641L	0.4
CESC	chr15	89312921	Silent	novel	L1223L	0.41
CESC	chr15	89273431	Missense_Mutation	NA	L313F	0.18
CESC	chr15	89281779	Silent	novel	V509V	0.14
COAD	chr15	89263979	Missense_Mutation	NA	Q208E	0.28
COAD	chr15	89283021	Intron	novel		0.36
COAD	chr15	89295065	Missense_Mutation	novel	K869N	0.32
COAD	chr15	89303912	Missense_Mutation	rs149167939	R1019W	0.2
COAD	chr15	89292810	Missense_Mutation	NA	I705M	0.35
COAD	chr15	89260752	Missense_Mutation	rs779515039	R66H	0.42
COAD	chr15	89316639	3'UTR	novel		0.36
COAD	chr15	89281774	Nonsense_Mutation	NA	K508*	0.05
COAD	chr15	89301332	Missense_Mutation	NA	L966V	0.39
COAD	chr15	89316884	3'UTR	novel		0.23
COAD	chr15	89299906	Missense_Mutation	NA	I915L	0.28
COAD	chr15	89305656	Missense_Mutation	NA	I1103L	0.22
COAD	chr15	89312923	Missense_Mutation	NA	N1224S	0.3
COAD	chr15	89261673	Missense_Mutation	NA	S126Y	0.25
COAD	chr15	89293864	Missense_Mutation	novel	F775I	0.1
COAD	chr15	89247660	Frame_Shift_Ins	NA	*L6Ffs23**	0.15
COAD	chr15	89292843	Silent	novel	S716S	0.04
ESCA	chr15	89261633	Missense_Mutation	novel	I113V	0.2
ESCA	chr15	89281853	Intron	novel		0.4
ESCA	chr15	89316457	Nonstop_Mutation	novel	1329Qext6	0.18
GBM	chr15	89316400	Missense_Mutation	NA	T1310A	0.3
GBM	chr15	89316458	Nonstop_Mutation	NA	1329Sext6	0.4
GBM	chr15	89306091	Missense_Mutation	novel	F1145Y	0.4
GBM	chr15	89261658	Missense_Mutation	novel	L121R	0.09
GBM	chr15	89283114	Intron	novel		0.69
GBM	chr15	89307667	Missense_Mutation	novel	V1216I	0.13
GBM	chr15	89281221	Missense_Mutation	novel	S478C	0.08
GBM	chr15	89299861	Missense_Mutation	novel	K900Q	0.32
HNSC	chr15	89301325	Splice_Site	novel	X964_splice	0.06
HNSC	chr15	89263925	Missense_Mutation	novel	E190K	0.14
HNSC	chr15	89258772	Silent	novel	F51F	0.14
HNSC	chr15	89293945	Missense_Mutation	novel	D802N	0.17
HNSC	chr15	89260817	Missense_Mutation	novel	E88Q	0.32
HNSC	chr15	89299835	Missense_Mutation	rs773239544	S891L	0.28
HNSC	chr15	89283067	Intron	novel		0.09
HNSC	chr15	89260775	Missense_Mutation	novel	Q74E	0.16
HNSC	chr15	89292995	Missense_Mutation	novel	I741M	0.1
KIRC	chr15	89276783	Silent	novel	P395P	0.35
KIRC	chr15	89316447	Silent	NA	K1325K	0.21
KIRC	chr15	89293853	Missense_Mutation	NA	I771T	0.28
KIRC	chr15	89300351	Missense_Mutation	novel	T952S	0.14
KIRP	chr15	89258739	Frame_Shift_Del	novel	*V42Lfs6**	0.48
KIRP	chr15	89312933	Silent	NA	G1227G	0.42
LGG	chr15	89293926	Missense_Mutation	novel	K795N	0.29
LGG	chr15	89261625	Missense_Mutation	rs368987143	N110S	0.06
LIHC	chr15	89283150	Missense_Mutation	rs368127142	R533Q	0.4
LIHC	chr15	89301429	Missense_Mutation	NA	P998L	0.29
LUAD	chr15	89263928	Missense_Mutation	NA	V191L	0.43
LUAD	chr15	89293050	Missense_Mutation	rs780410177	I760V	0.09
LUAD	chr15	89306009	Missense_Mutation	novel	E1118Q	0.22
LUAD	chr15	89305359	Frame_Shift_Ins	novel	*T1069Sfs39**	0.09
LUAD	chr15	89305360	Nonsense_Mutation	novel	N1070_H1071ins*	0.09
LUAD	chr15	89281297	Silent	novel	V503V	0.32
LUAD	chr15	89291698	Missense_Mutation	rs776139524	S659F	0.16
LUAD	chr15	89261833	Missense_Mutation	NA	G153V	0.45
LUAD	chr15	89292840	Missense_Mutation	NA	K715N	0.08
LUAD	chr15	89293928	Missense_Mutation	NA	M796T	0.47
LUAD	chr15	89273469	Missense_Mutation	novel	Q325H	0.1
LUAD	chr15	89290231	Nonsense_Mutation	rs551399966	R614*	0.15
LUAD	chr15	89283065	Intron	novel		0.48
LUAD	chr15	89268444	Silent	novel	V267V	0.12
LUAD	chr15	89268445	Nonsense_Mutation	novel	E268*	0.12
LUSC	chr15	89315384	Missense_Mutation	novel	E1307Q	0.16
LUSC	chr15	89299902	Missense_Mutation	novel	Q913H	0.35
LUSC	chr15	89306117	Missense_Mutation	novel	P1154S	0.28
LUSC	chr15	89300316	In_Frame_Del	rs769118889	G941del	0.17
LUSC	chr15	89291657	Silent	novel	L645L	0.39
LUSC	chr15	89281793	Missense_Mutation	novel	R514K	0.71
LUSC	chr15	89307643	Silent	novel	L1208L	0.1
LUSC	chr15	89307502	Silent	novel	G1188G	0.27
LUSC	chr15	89281950	Intron	novel		0.31
LUSC	chr15	89261683	Missense_Mutation	novel	L129F	0.36
LUSC	chr15	89264601	Missense_Mutation	novel	G250V	0.4
LUSC	chr15	89261608	Silent	novel	L104L	0.29
MESO	chr15	89273406	Missense_Mutation	novel	N304K	0.44
OV	chr15	89306127	Missense_Mutation	novel	S1157T	0.07
OV	chr15	89307512	Missense_Mutation	novel	K1192E	0.06
OV	chr15	89306072	Missense_Mutation	novel	G1139R	0.12
OV	chr15	89316696	3'UTR	novel		0.22
OV	chr15	89316847	3'UTR	novel		0.6
OV	chr15	89316913	3'UTR	novel		0.34
OV	chr15	89316838	3'UTR	novel		0.08
OV	chr15	89290223	Missense_Mutation	NA	D611G	0.91
OV	chr15	89312941	Missense_Mutation	novel	K1230R	0.05
OV	chr15	89316863	3'UTR	novel		0.44
PAAD	chr15	89316869	3'UTR	novel		0.19
PCPG	chr15	89261665	Missense_Mutation	novel	N123K	0.35
PRAD	chr15	89258708	Missense_Mutation	rs199713555	T30I	0.32
READ	chr15	89268505	Nonsense_Mutation	NA	E288*	0.23
READ	chr15	89316951	3'UTR	rs186201462		0.14
READ	chr15	89268454	Missense_Mutation	NA	I271F	0.1
READ	chr15	89274185	Missense_Mutation	NA	K331N	0.43
READ	chr15	89291624	Missense_Mutation	novel	F634L	0.41
READ	chr15	89274218	Missense_Mutation	novel	Q342H	0.36
READ	chr15	89283150	Missense_Mutation	rs368127142	R533Q	0.15
SARC	chr15	89293994	Missense_Mutation	novel	F818C	0.27
SARC	chr15	89316453	Silent	novel	K1327K	0.07
SKCM	chr15	89281186	Silent	rs201002833	I466I	0.18
SKCM	chr15	89306016	Missense_Mutation	NA	S1120F	0.41
SKCM	chr15	89305671	Missense_Mutation	NA	G1108R	0.32
SKCM	chr15	89293944	Silent	novel	S801S	0.33
SKCM	chr15	89292688	Missense_Mutation	NA	D665N	0.28
SKCM	chr15	89263910	Missense_Mutation	novel	P185S	0.36
SKCM	chr15	89307504	Missense_Mutation	NA	G1189E	1
SKCM	chr15	89283149	Nonsense_Mutation	NA	R533*	0.41
SKCM	chr15	89261824	Missense_Mutation	NA	V150E	0.65
SKCM	chr15	89273413	Missense_Mutation	rs769485443	P307S	0.35
SKCM	chr15	89299941	Silent	novel	K926K	0.21
SKCM	chr15	89276861	Silent	rs376956791	L421L	0.22
SKCM	chr15	89281857	Intron	novel		0.3
SKCM	chr15	89305169	Missense_Mutation	NA	S1038L	0.35
SKCM	chr15	89263982	Missense_Mutation	NA	E209K	0.23
SKCM	chr15	89305116	Splice_Region	NA	E1020E	0.24
SKCM	chr15	89260788	Missense_Mutation	rs754443451	S78L	0.17
SKCM	chr15	89285127	Missense_Mutation	NA	S577F	0.11
SKCM	chr15	89268460	Silent	NA	L273L	0.24
SKCM	chr15	89299809	Silent	rs199627578	L882L	0.38
SKCM	chr15	89292818	Missense_Mutation	NA	S708F	0.14
SKCM	chr15	89281847	Intron	novel		0.52
STAD	chr15	89283170	Frame_Shift_Del	novel	*L541Cfs4**	0.21
STAD	chr15	89305195	Missense_Mutation	NA	R1047C	0.38
STAD	chr15	89285201	Nonsense_Mutation	novel	R602*	0.43
STAD	chr15	89268449	Missense_Mutation	NA	G269V	0.04
STAD	chr15	89283021	Intron	novel		0.28
STAD	chr15	89264605	Splice_Region	rs151169233	D251D	0.24
STAD	chr15	89263961	Missense_Mutation	NA	F202L	0.34
STAD	chr15	89306096	Missense_Mutation	NA	E1147K	0.33
STAD	chr15	89301382	Silent	rs762453164	A982A	0.23
STAD	chr15	89263432	Missense_Mutation	novel	Y173N	0.33
STAD	chr15	89301409	Silent	NA	S991S	0.13
STAD	chr15	89258752	Missense_Mutation	NA	A45T	0.35
STAD	chr15	89290210	Splice_Region	novel		0.11
STAD	chr15	89285149	Silent	NA	C584C	0.81
STAD	chr15	89264631	Intron	novel		0.1
STAD	chr15	89293885	Missense_Mutation	NA	S782A	0.12
STAD	chr15	89305123	Silent	NA	L1023L	0.23
STAD	chr15	89285188	Silent	NA	Q597Q	0.1
STAD	chr15	89315344	Silent	NA	I1293I	0.18
STAD	chr15	89292777	Silent	novel	E694E	0.42
TGCT	chr15	89281215	Missense_Mutation	novel	S476N	0.28
THCA	chr15	89312932	Missense_Mutation	novel	G1227E	0.09
THYM	chr15	89315319	Missense_Mutation	rs121918163	R1285Q	0.4
UCEC	chr15	89307638	Frame_Shift_Del	novel	*L1208Cfs16**	0.33
UCEC	chr15	89300346	Silent	NA	S950S	0.43
UCEC	chr15	89285119	Missense_Mutation	NA	H574Q	0.29
UCEC	chr15	89292830	Missense_Mutation	NA	R712I	0.35
UCEC	chr15	89295011	Silent	NA	Q851Q	0.35
UCEC	chr15	89317023	3'UTR	novel		0.4
UCEC	chr15	89314681	Missense_Mutation	NA	L1264I	0.31
UCEC	chr15	89316709	3'UTR	rs781373845		0.31
UCEC	chr15	89285172	Missense_Mutation	novel	R592M	0.33
UCEC	chr15	89316607	3'UTR	novel		0.44
UCEC	chr15	89281171	Splice_Region	novel	D461D	0.39
UCEC	chr15	89293922	Missense_Mutation	novel	T794N	0.42
UCEC	chr15	89305402	Missense_Mutation	novel	T1083I	0.09
UCEC	chr15	89307511	Frame_Shift_Del	novel	*N1193Ifs6**	0.32
UCEC	chr15	89261713	Silent	rs776382823	T139T	0.45
UCEC	chr15	89273443	Missense_Mutation	novel	T317S	0.65
UCEC	chr15	89292712	Missense_Mutation	rs763866498	H673Y	0.41
UCEC	chr15	89276733	Missense_Mutation	novel	T379A	0.44
UCEC	chr15	89258764	Missense_Mutation	novel	A49T	0.28
UCEC	chr15	89307511	Frame_Shift_Del	novel	*N1193Ifs6**	0.2
UCEC	chr15	89290232	Missense_Mutation	rs757285246	R614Q	0.2
UCEC	chr15	89316597	3'UTR	novel		0.24
UCEC	chr15	89312962	Missense_Mutation	NA	A1237V	0.16
UCEC	chr15	89293928	Missense_Mutation	NA	M796T	0.37
UCEC	chr15	89281977	Intron	novel		0.14
UCEC	chr15	89293938	Missense_Mutation	novel	K799N	0.11
UCEC	chr15	89307511	Frame_Shift_Del	novel	*N1193Ifs6**	0.37
UCEC	chr15	89281281	Missense_Mutation	novel	R498M	0.2
UCEC	chr15	89247659	Missense_Mutation	novel	K4N	0.44
UCEC	chr15	89283187	Missense_Mutation	novel	K545N	0.09
UCEC	chr15	89285132	Missense_Mutation	rs147963936	A579T	0.28
UCEC	chr15	89291624	Missense_Mutation	novel	F634L	0.41
UCEC	chr15	89274277	Missense_Mutation	novel	T362I	0.36
UCEC	chr15	89263960	Missense_Mutation	novel	M201I	0.14
UCEC	chr15	89258707	Missense_Mutation	novel	T30A	0.49
UCEC	chr15	89276711	Splice_Region	rs780568718	S371S	0.38
UCEC	chr15	89281868	Intron	novel		0.33
UCEC	chr15	89282907	Intron	novel		0.44
UCEC	chr15	89295085	Missense_Mutation	rs545673916	D876G	0.32
UCEC	chr15	89273456	Missense_Mutation	novel	R321K	0.32
UCEC	chr15	89291624	Missense_Mutation	novel	F634L	0.38
UCEC	chr15	89260783	Silent	novel	V76V	0.44
UCEC	chr15	89293841	Missense_Mutation	novel	R767M	0.43
UCEC	chr15	89306192	Missense_Mutation	novel	Y1179H	0.39
UCEC	chr15	89276862	Missense_Mutation	rs146040966	G422R	0.23
UCEC	chr15	89274229	Missense_Mutation	novel	G346D	0.58
UCEC	chr15	89293035	Nonsense_Mutation	novel	E755*	0.44
UCEC	chr15	89294991	Missense_Mutation	novel	V845I	0.46
UCEC	chr15	89316549	3'UTR	rs528800761		0.43
UCEC	chr15	89301390	Missense_Mutation	NA	L985R	0.35
UCEC	chr15	89305692	Silent	NA	L1115L	0.19
UCEC	chr15	89291688	Missense_Mutation	novel	D656N	0.44
UCEC	chr15	89293964	Missense_Mutation	novel	K808T	0.48
UCEC	chr15	89299929	Missense_Mutation	novel	F922L	0.4
UCEC	chr15	89293957	Missense_Mutation	novel	S806P	0.25
UCEC	chr15	89263969	Missense_Mutation	novel	K204N	0.14
UCEC	chr15	89274185	Missense_Mutation	NA	K331N	0.21
UCEC	chr15	89292842	Missense_Mutation	rs753121112	S716N	0.21
UCEC	chr15	89315286	Missense_Mutation	novel	N1274S	0.06
UCEC	chr15	89316455	Missense_Mutation	novel	K1328R	0.11
UCEC	chr15	89263992	Missense_Mutation	NA	P212H	0.08
UCEC	chr15	89273385	Silent	rs746939739	Q297Q	0.08
UCEC	chr15	89316664	3'UTR	novel		0.35
UCEC	chr15	89293930	Missense_Mutation	NA	A797T	0.39
UCEC	chr15	89283153	Missense_Mutation	novel	K534R	0.35
UCEC	chr15	89307667	Missense_Mutation	novel	V1216I	0.3
UCEC	chr15	89281910	Intron	novel		0.54
UCEC	chr15	89300357	Missense_Mutation	novel	R954I	0.22
UCEC	chr15	89314678	Missense_Mutation	novel	F1263I	0.25
UCEC	chr15	89315361	Missense_Mutation	rs138663330	R1299Q	0.47
UCEC	chr15	89273399	Missense_Mutation	rs575416245	N302S	0.04
UCEC	chr15	89316854	3'UTR	novel		0.07
UCEC	chr15	89263992	Missense_Mutation	NA	P212H	0.09
UCEC	chr15	89281949	Intron	novel		0.35
UCEC	chr15	89300314	Nonsense_Mutation	novel	E940*	0.51
UCEC	chr15	89294981	Silent	novel	Y841Y	0.29
UCEC	chr15	89307489	Missense_Mutation	novel	C1184Y	0.32
UCEC	chr15	89315297	Missense_Mutation	rs776134519	H1278Y	0.39
UCEC	chr15	89305383	Nonsense_Mutation	novel	L1077*	0.03
UCEC	chr15	89273429	Missense_Mutation	novel	L312P	0.09
UCEC	chr15	89282975	Intron	novel		0.62
UCEC	chr15	89247684	Missense_Mutation	NA	T13S	0.47
UCEC	chr15	89305612	Missense_Mutation	novel	V1088A	0.05
UCEC	chr15	89293932	Silent	novel	A797A	0.5
UCEC	chr15	89274185	Missense_Mutation	NA	K331N	0.31
UCEC	chr15	89281847	Intron	novel		0.21
UCEC	chr15	89291616	Missense_Mutation	NA	K632Q	0.3
UCEC	chr15	89312911	Missense_Mutation	NA	S1220I	0.26
UCEC	chr15	89305388	Silent	novel	R1078R	0.41
UCEC	chr15	89305177	Missense_Mutation	novel	S1041R	0.17
UCEC	chr15	89305624	Missense_Mutation	novel	A1092V	0.13
UCEC	chr15	89315347	Silent	novel	L1294L	0.23
UCEC	chr15	89316430	Nonsense_Mutation	novel	E1320*	0.13
UCEC	chr15	89316947	3'UTR	novel		0.16
UCEC	chr15	89305683	Frame_Shift_Ins	novel		0.03
UCEC	chr15	89307621	Silent	novel	L1200L	0.38
UCEC	chr15	89312929	Missense_Mutation	rs367665900	T1226M	0.51
UCEC	chr15	89273455	Silent	novel	R321R	0.41
UCEC	chr15	89283102	Intron	novel		0.35
UCEC	chr15	89305609	Missense_Mutation	novel	L1087H	0.31
UCS	chr15	89274235	Missense_Mutation	novel	K348T	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2169	0.0058042
ESCA	AMP	0.2228	0.10665
LGG	AMP	0.0214	0.19963
LIHC	DEL	0.1703	0.056724
PAAD	AMP	0.0761	0.20695
SKCM	AMP	0.2452	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.002	Kaplan-Meier Survival Analysis
KIRC	0.0037	Kaplan-Meier Survival Analysis
STAD	0.024	Kaplan-Meier Survival Analysis
SARC	0.012	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
SKCM	0.0072	Kaplan-Meier Survival Analysis
PRAD	0.02	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
PAAD	0.00047	Kaplan-Meier Survival Analysis
PCPG	0.0096	Kaplan-Meier Survival Analysis
CESC	0.0051	Kaplan-Meier Survival Analysis
READ	0.041	Kaplan-Meier Survival Analysis
KICH	0.0017	Kaplan-Meier Survival Analysis
LIHC	0.00018	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0002	Kaplan-Meier Survival Analysis
UVM	0.0065	Kaplan-Meier Survival Analysis
OV	0.0081	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000140525 (Gene tree)
Gene ID: 55215
Gene Symbol: FANCI
Alias: FLJ10719|KIAA1794
Full Name: FA complementation group I
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 73,314 bases
Position: chr15:89,243,948-89,317,261
Accession: 25568
Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000310775	FANCI-202	4743	XM_011521756	ENSP00000310842	1328 (aa)	XP_011520058	Q9NVI1
ENST00000447611	FANCI-203	3690	-	ENSP00000413249	1095 (aa)	-	F8W7R3
ENST00000565522	FANCI-210	233	-	-	- (aa)	-	-
ENST00000568670	FANCI-215	285	-	-	- (aa)	-	-
ENST00000300027	FANCI-201	4713	XM_011521764	ENSP00000300027	1268 (aa)	XP_011520066	Q9NVI1
ENST00000565255	FANCI-209	754	-	ENSP00000454371	226 (aa)	-	H3BMG4
ENST00000570225	FANCI-217	526	-	ENSP00000454669	145 (aa)	-	H3BN35
ENST00000564920	FANCI-208	562	-	ENSP00000456552	125 (aa)	-	H3BS60
ENST00000567891	FANCI-213	584	-	ENSP00000455735	157 (aa)	-	H3BQE2
ENST00000561894	FANCI-204	3268	-	ENSP00000455189	1090 (aa)	-	H3BP78
ENST00000567996	FANCI-214	1070	-	ENSP00000458024	252 (aa)	-	Q9NVI1
ENST00000566615	FANCI-211	537	-	-	- (aa)	-	-
ENST00000564350	FANCI-206	761	-	-	- (aa)	-	-
ENST00000563250	FANCI-205	700	-	ENSP00000457029	215 (aa)	-	H3BT54
ENST00000564636	FANCI-207	777	-	-	- (aa)	-	-
ENST00000566895	FANCI-212	4663	-	-	- (aa)	-	-
ENST00000570110	FANCI-216	528	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03460	Fanconi anemia pathway	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000140525	Body Height	2E-12	25282103

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140525	rs2238300	15	89308349	A	Height	25282103	[0.015-0.027] unit decrease	0.021	EFO_0004339

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140525's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0005515	protein binding	17460694.20603015.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007049	cell cycle	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0031398	positive regulation of protein ubiquitination	18029348.	IDA	Process
GO:0036297	interstrand cross-link repair	-	TAS	Process
GO:0070182	DNA polymerase binding	21873635.	IBA	Function
GO:0070182	DNA polymerase binding	19995904.	IPI	Function

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.